Erschienen in:
01.04.2013 | Brief Research Article
Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients
verfasst von:
Xu Liang, Jie Zhang, Yulin Zhu, Yuanli Lu, Xinna Zhou, Zheng Wang, Jing Yu, Ying Yan, Lijun Di, Li Che, Hanfang Jiang, Bin Shao, Xiaoli Wang, Huabing Yang, Herbert Kim Lyerly, Jun Ren
Erschienen in:
Clinical and Translational Oncology
|
Ausgabe 4/2013
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Abstract
Aim
This study was designed to explore the genetic polymorphism of IL-10 (−1082A/G, −592A/C, −819T/C), TNF-α (−308G/A) with susceptibility to docetaxel-induced liver injury (DILI) in Chinese breast cancer patients.
Methods
The targeted genetic polymorphisms of IL10-1082G/A, IL10-592A/C, IL10-819T/C, TNF-308G/A from 40 patients with DILI were assayed by matrix-assisted laser desorption/ionization-time of flight of Sequenom.
Results
AA genotype of IL10-592 and TT of IL10-819 significantly increased incidence of DILI (P = 0.005, OR = 3.137). No differences of TNF gene polymorphism between the two groups were seen.
Conclusion
The genetic polymorphism of the IL10-592A/C AA genotype and IL10-819T/C TT genotype was predominantly conferred to the incidence of docetaxel-induced liver injury.