Skip to main content
main-content

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Clinical and Translational Allergy 1/2014

Specific IgE to fish extracts does not predict allergy to specific species within an adult fish allergic population

Zeitschrift:
Clinical and Translational Allergy > Ausgabe 1/2014
Autoren:
Karlijn JG Schulkes, Rob JB Klemans, Lidy Knigge, Marjolein de Bruin-Weller, Carla AFM Bruijnzeel-Koomen, Åsa Marknell deWitt, Jonas Lidholm, André C Knulst
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​2045-7022-4-27) contains supplementary material, which is available to authorized users.

Competing interest

A Marknell DeWitt and J Lidholm are employed by Thermo Fisher Scientific (Uppsala, Sweden), manufacturer of the IgE assay system used in this study. The other authors reported no possible competing interest.

Authors’ contributions

KJGS: Substantial contributions to conception and design, acquisition, analysis and interpretation of data, drafting article and final approval of version to be published. RJBK: Substantial contributions to conception and design, acquisition, analysis and interpretation of data, drafting article and final approval of version to be published. LK: Substantial contributions to conception and design, acquisition, analysis and interpretation of data, drafting article and final approval of version to be published. MdeB-W: Substantial contributions to conception and design, revising the article critically for important intellectual content and final approval of version to be published. CAFMB-K: Substantial contributions to conception and design, revising the article critically for important intellectual content and final approval of version to be published. ÅMDeW: Substantial contribution to acquisition of data, revising the article critically for important intellectual content and final approval of version to be published. JL: Substantial contributions to conception and design, acquisition and interpretation of data, revising the article critically for important intellectual content and final approval of version to be published. ACK: Substantial contributions to conception and design, interpretation of data, revising the article critically for important intellectual content and final approval of version to be published.

Abstract

Background

Fish is an important cause of food allergy. Studies on fish allergy are scarce and in most cases limited to serological evaluation. Our objective was to study patterns of self-reported allergy and tolerance to different commonly consumed fish species and its correlation to IgE sensitization to the same species.

Methods

Thirty-eight adult fish allergic patients completed a questionnaire regarding atopy, age of onset and symptoms to 13 commonly consumed fish species in the Netherlands (pangasius, cod, herring, eel, hake, pollock, mackerel, tilapia, salmon, sardine, tuna, plaice and swordfish). Specific IgE to these fish extracts were analyzed by ImmunoCAP.

Results

Median age of onset of fish allergy was 8.5 years. Severe reactions were reported by the majority of patients (n = 20 (53%) respiratory and of these 20 patients, 6 also had cardiovascular symptoms). After diagnosis, 66% of the patients had eliminated all fish from their diet. Allergy to all species ever tried was reported by 59%. In relation to species ever tried, cod (84%) and herring (79%) were the most frequently reported culprit species while hake (57%) and swordfish (55%) were the least frequent. A positive sIgE (value ≥ 0.35 kUA/L) to the culprit species ranged between 50% (swordfish) and 100% (hake). In tolerant patients, a negative sIgE (value < 0.35 kUA/L) ranged from 0% (hake, pollock and swordfish) to 75% (sardine). For cod, the agreement between sIgE test results and reported allergy or tolerance was 82% and 25%, respectively. Sensitization to cod parvalbumin (Gad c 1) was present in 77% of all patients.

Conclusion

Serological cross-reactivity between fish species is frequent, but in a significant proportion of patients, clinical relevance appears to be limited to only certain species. A well-taken history or food challenge is required for discrimination between allergy to the different fish species.
Zusatzmaterial
Authors’ original file for figure 1
13601_2014_1060_MOESM1_ESM.pdf
Authors’ original file for figure 2
13601_2014_1060_MOESM2_ESM.pdf
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2014

Clinical and Translational Allergy 1/2014 Zur Ausgabe

Reviewer acknowledgement

Reviewer acknowledgement 2013

Neu im Fachgebiet HNO

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update HNO und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise