Cognitive changes are common among breast cancer survivors. There is limited evidence to guide management of cognitive changes. This randomized controlled pilot evaluated the preliminary efficacy of a speed of processing (SOP) training among middle-aged and older breast cancer survivors.
Sixty breast cancer survivors with self-reported cognitive changes were recruited to the SOAR study. Participants were randomized to either a home-based SOP training (n = 30) or no-contact control group (n = 30). Primary outcomes were SOP (Useful Field of View Test®), and executive function (NIH Toolbox Cognition Battery). Neuropsychological assessments were completed at baseline, 6 weeks, and 6 months post study entry. Data were analyzed using repeated measures t tests, analysis of covariance, and sensitivity analyses.
SOP training resulted in improvement in objective measures of SOP and executive function. Immediate (6 week) posttest and 6-month follow-up demonstrated large SOP training effects over time. Large representation of African American women (51.2%) and 96% retention in the SOAR study add to study strengths.
Home-based SOP training shows promise for remediating cognitive changes following breast cancer treatment, particularly improved SOP, and executive function.
Howlander N, Noone AM, Krapcho M., Miller D, Bishop K, Kosary CL, Yu M, Ruhl J, TatalovichZ, Mariotto A, Lewis DR, Chen HS, Feuer EK. Cronin KA (eds.). SEER cancer statistics review, 1975-2014. National Cancer Institute https://seer.cancer.gov/csr/1975_2014/. Accessed 7 Sept 2017
American Cancer Soociety (2017) Cancer treatment and survivorship facts and figures. American Cancer Society, Atlanta
Frank JS, Vance DE, Jukkala A, Meneses KM (2014) Attention and memory deficits in breast cancer survivors: implications for nursing practice and research. J Neurosci Nurs 46(5):274–284. https://doi.org/10.1097/JNN.0000000000000078CrossRefPubMed
Vance DE, Fazeli PL, Ross LA, Wadley VG, Ball KK (2012) Speed of processing training with middle-age and older adults with HIV: a pilot study. J Assoc Nurses AIDS Care 23(6):500–510. https://doi.org/10.1016/j.jana.2012.01.005CrossRefPubMedPubMedCentral
Vance DE, Frank JS, Bail J, Triebel K, Niccolai L, Gertenecker A, Meneses K (2017) Interventions for cognitive deficits in breast cancer survivors treated with chemotherapy. Cancer Nurs 40(1):E11–E27. https://doi.org/10.1097/NCC.0000000000000349CrossRefPubMed
Von Ah D, Carpenter JS, Saykin A, Monahan P, Wu J, Yu M, Rebok G, Ball K, Schneider B, Weaver M, Tallman E, Uneverzagt F (2012) Advanced cognitive training for breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 135(3):799–809. https://doi.org/10.1007/s10549-012-2210-6CrossRef
BrainHq. Posit Science. Available at www.brainhq.com, 2016
Edwards JD, Ross LA, Wadley VG, Clay OJ, Crowe M, Roenker DL, Ball KK (2006) The useful field of view test: normative data for older adults. Arch Clin Neuropsychol 21:275–286. https://doi.org/10.1016/j.acn.2006.03.001CrossRefPubMed
Weintraub S, Dikmen SS, Heaton RK, Tutsky DS, Aelazo PD, Bauer PJ, Carlozzi NE, Slotkin J, Blitz D, Wallner-Allen K, Fox NA, Beaumont JL, Mungas D, Nowinski CJ, Richler J, Deocampo JA, Anderson JE, Manly JJ, Borosh B, Havlik R, Conway K, Edwards E, Freund L, King JW, Moy C, Witt E, Gershon RC (2013) Cognition assessment using the NIH Toolbox. Neurology 80(11 Suppl 3):S54–S64. https://doi.org/10.1212/WNL.0b013e3182872dedCrossRefPubMedPubMedCentral
Slotkin J, Nowinski C, Hays R, Beaumont J, Griffith J, Magasi S, Salsman J, Gershon R (2012) NIH Toolbox scoring and interpretation guide. National Institutes of Health, Washington (DC)
Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Earlbaum Associates, Hillsdale
Wolinsky FD, Vander Weg MW, Martin R, Unverzagt FW, Willis SL, Marsiske M, Rebok GW, Morris JN, Ball KK, Tennstedt SL (2010) Does cognitive training improve internal locus of control among older adults ?. J Gerontol B Psychol Sci Soc Sci 65(5):591–598. https://doi.org/10.1093/geronb/gbp117CrossRefPubMed
Lampit AH, Hallock H, Valenzuela M (2014) Computerized cognitive training in cognitively healthy older adults: a systematic review and meta-analysis of effect modifiers. PLoS Med 11(11):e1001756. https://doi.org/10.1371/journal.pmed.1001756CrossRefPubMedPubMedCentral
Edwards JD, Xu H, Clark D, Ross LA, Unverzagt F (2016) The ACTIVE study: what we have learned and what is next? Cognitive training reduces incident dementia across ten years. Alzheimer’s & Dementia 12(7):212 CrossRef
Vance DE, Fazeli P, Shacka J, Nicholson W, McKie P, Raper J, Azuero A, Wadley V, Ball KK (2017) Testing a computerized cognitive training protocol in adults aging with HIV-associated neurocognitive disorders: randomized controlled trial rationale and protocol. JMIR Res Protoc 6(4):e68. https://doi.org/10.2196/resprot.6625CrossRefPubMedPubMedCentral
Wadley VG, Benz RL, Ball KK, Roenker DL, Edwards JD, Vance DE (2006) Development and evaluation of home-based speed-of-processing training for older adults. Arch Phys Med Rehabil 87(6):757–763. https://doi.org/10.1016/j.apmr.2006.02.027CrossRefPubMed
- Speed of processing training in middle-aged and older breast cancer survivors (SOAR): results of a randomized controlled pilot
Jennifer R. Bail
Jacqueline B. Vo
David E. Vance
- Springer US
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