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Neuroscience Bulletin
Erschienen in:

01.06.2019 | Review

Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury

verfasst von: Qian Huang, Wanru Duan, Eellan Sivanesan, Shuguang Liu, Fei Yang, Zhiyong Chen, Neil C. Ford, Xueming Chen, Yun Guan

Erschienen in: Neuroscience Bulletin | Ausgabe 3/2019

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Abstract

In addition to restoration of bladder, bowel, and motor functions, alleviating the accompanying debilitating pain is equally important for improving the quality of life of patients with spinal cord injury (SCI). Currently, however, the treatment of chronic pain after SCI remains a largely unmet need. Electrical spinal cord stimulation (SCS) has been used to manage a variety of chronic pain conditions that are refractory to pharmacotherapy. Yet, its efficacy, benefit profiles, and mechanisms of action in SCI pain remain elusive, due to limited research, methodological weaknesses in previous clinical studies, and a lack of mechanistic exploration of SCS for SCI pain control. We aim to review recent studies and outline the therapeutic potential of different SCS paradigms for traumatic SCI pain. We begin with an overview of its manifestations, classification, potential underlying etiology, and current challenges for its treatment. The clinical evidence for using SCS in SCI pain is then reviewed. Finally, future perspectives of pre-clinical research and clinical study of SCS for SCI pain treatment are discussed.
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Metadaten
Titel
Spinal Cord Stimulation for Pain Treatment After Spinal Cord Injury
verfasst von
Qian Huang
Wanru Duan
Eellan Sivanesan
Shuguang Liu
Fei Yang
Zhiyong Chen
Neil C. Ford
Xueming Chen
Yun Guan
Publikationsdatum
01.06.2019
Verlag
Springer Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 3/2019
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-018-0320-9

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