The online version of this article (doi:10.1186/1752-1947-8-425) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
MS analyzed data, interpreted results, prepared figures, drafted manuscript, conception and design of research, and approved final version of the manuscript. AD and RS analyzed data, interpreted results of experiments, prepared figures, and drafted the manuscript. LP and SG analyzed data, interpreted results of experiments, prepared figures, drafted the manuscript, and edited and revised the manuscript. IP and TP interpreted results of the radiology protocols, and edited and revised the manuscript. All authors read and approved the final manuscript.
Computed tomography and magnetic resonance imaging are able to demonstrate and to diagnose hepatic focal nodular hyperplasia when a typical pattern of a well-circumscribed lesion with a central scar is present.
Our aim is to propose the split-bolus multidetector-row computed tomography technique as an alternative to the conventional triphasic technique in the detection and characterization of focal nodular hyperplasia to reduce the radiation dose to the patient.
To the best of our knowledge, this is the first report regarding the application of the split-bolus computed tomography technique in the evaluation of hepatic focal nodular hyperplasia.
We describe a case of focal nodular hyperplasia of the liver in a 53-year-old Caucasian woman (weight 75Kg) with a colorectal adenocarcinoma histologically confirmed. An innovative split-bolus multidetector-row computed tomography technique was used that, by splitting intravenous contrast material in two boli, combined two phases (hepatic arterial phase and portal venous phase) in a single pass; a delayed (5 minutes) phase was obtained to compare the findings with that of triphasic multidetector-row computed tomography.
Split-bolus multidetector-row computed tomography was able to show the same appearance of the lesion as the triphasic multidetector-row computed tomography technique.
This is the first case demonstrating the effectiveness of the split-bolus multidetector-row computed tomography technique in the detection and characterization of focal nodular hyperplasia with a significant reduction in radiation dose to the patient with respect to triphasic multidetector-row computed tomography technique.
Authors’ original file for figure 113256_2014_3024_MOESM1_ESM.tif
Authors’ original file for figure 213256_2014_3024_MOESM2_ESM.tif
Authors’ original file for figure 313256_2014_3024_MOESM3_ESM.tif
Authors’ original file for figure 413256_2014_3024_MOESM4_ESM.tif
Authors’ original file for figure 513256_2014_3024_MOESM5_ESM.jpeg
Authors’ original file for figure 613256_2014_3024_MOESM6_ESM.jpeg
Authors’ original file for figure 713256_2014_3024_MOESM7_ESM.jpeg
Authors’ original file for figure 813256_2014_3024_MOESM8_ESM.jpeg
Craig JR, Peters RL, Edmondson HA: Tumors of the Liver and Intrahepatic Bile Ducts. Fasc 26, 2nd Serv. 1989, Washington, DC: Armed Forces Institute of Pathology
Wanless IR, Albrecht S, Bilbao J, Frei JV, Heathcote EJ, Roberts EA: Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome. Mod Pathol. 1989, 2: 456-462. PubMed
Mathieu D, Vilgrain V, Mahfouz AE, Anglade MC, Vullierme MP, Denys A: Benign liver tumors. Magn Reson Imaging Clin N Am. 1997, 5: 255-288. PubMed
Bieze M, van den Esschert JW, Nio CY, Verheij J, Reitsma JB, Terpstra V, van Gulik TM, Phoa SS: Diagnostic accuracy of MRI in differentiating hepatocellular adenoma from focal nodular hyperplasia: prospective study of the additional value of gadoxetate disodium. AJR Am J Roentgenol. 2012, 199: 26-34. 10.2214/AJR.11.7750. CrossRefPubMed
Scialpi M, Palumbo B, Pierotti L, Gravante S, Piunno A, Rebonato A, D’Andrea A, Reginelli A, Piscioli I, Brunese L, Rotondo A: Detection and characterization of focal liver lesions by split-bolus multidetector-row CT: diagnostic accuracy and radiation dose in oncologic patients. Anticancer Res. 2014, 34 (8): 4335-4344. PubMed
Portnoy O, Guranda L, Apter S, Eiss D, Amitai MM, Konen E: Optimization of 64-MDCT urography: effect of dual-phase imaging with furosemide on collecting system opacification and radiation dose. AJR Am J Roentgenol. 2011, 197 (5): 882-886. 10.2214/AJR.11.6965. CrossRef
Smith-Bindman R, Lipson J, Marcus R, Kim KP, Mahesh M, Gould R, Berrington De González A, Miglioretti DL: Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009, 169 (22): 2078-2086. 10.1001/archinternmed.2009.427. CrossRefPubMedPubMedCentral
Erturk SM, Ichikawa T, Sou H, Tsukamoto T, Motosugi U, Araki T: Effect of duration of contrast material injection on peak enhancement times and values of the aorta, main portal vein, and liver at dynamic MDCT with the dose of contrast medium tailored to patient weight. Clin Radiol. 2008, 63 (3): 263-271. 10.1016/j.crad.2007.02.024. CrossRefPubMed
- Split-bolus versus triphasic multidetector-row computed tomography technique in the diagnosis of hepatic focal nodular hyperplasia: a case report
- BioMed Central