Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
European Archives of Psychiatry and Clinical Neuroscience
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience 5/2014

01.08.2014 | Original Paper

SPOCK3, a risk gene for adult ADHD and personality disorders

verfasst von: Heike Weber, Claus-Jürgen Scholz, Christian P. Jacob, Julia Heupel, Sarah Kittel-Schneider, Angelika Erhardt, Susanne Hempel, Brigitte Schmidt, Tilman Kiel, Alexandra Gessner, Klaus-Peter Lesch, Andreas Reif

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is the most frequent psychiatric disorder in children, where it displays a global prevalence of 5 %. In up to 50 % of the cases, ADHD may persist into adulthood (aADHD), where it is often comorbid with personality disorders. Due to a potentially heritable nature of this comorbidity, we hypothesized that their genetic framework may contain common risk-modifying genes. SPOCK3, a poorly characterized, putatively Ca(2+)-binding extracellular heparan/chondroitin sulfate proteoglycan gene encoded by the human chromosomal region 4q32.3, was found to be associated with polymorphisms among the top ranks in a genome-wide association study (GWAS) on ADHD and a pooled GWAS on personality disorder (PD). We therefore genotyped 48 single nucleotide polymorphisms (SNPs) representative of the SPOCK3 gene region in 1,790 individuals (n aADHD = 624, n PD = 630, n controls = 536). In this analysis, we found two SNPs to be nominally associated with aADHD (rs7689440, rs897511) and four PD-associated SNPs (rs7689440, rs897511, rs17052671 and rs1485318); the latter even reached marginal significance after rigorous Bonferroni correction. Bioinformatics tools predicted a possible influence of rs1485318 on transcription factor binding, whereas the other candidate SNPs may have effects on alternative splicing. Our results suggest that SPOCK3 may modify the genetic risk for ADHD and PD; further studies are, however, needed to identify the underlying mechanisms.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Alcina A, Fernandez O, Gonzalez JR, Catala-Rabasa A, Fedetz M, Ndagire D, Leyva L, Guerrero M, Arnal C, Delgado C, Lucas M, Izquierdo G, Matesanz F (2010) Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for multiple sclerosis. Eur J Hum Genet 18:827–831PubMedCentralPubMedCrossRef
2.
Alliel PM, Perin JP, Jolles P, Bonnet FJ (1993) Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. Eur J Biochem 214:347–350PubMedCrossRef
3.
Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M (2010) A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry 15:1053–1066PubMedCrossRef
4.
Balint S, Czobor P, Meszaros A, Simon V, Bitter I (2008) Neuropsychological impairments in adult attention deficit hyperactivity disorder: a literature review. Psychiatr Hung 23:324–335PubMed
5.
Bandtlow CE, Zimmermann DR (2000) Proteoglycans in the developing brain: new conceptual insights for old proteins. Physiol Rev 80:1267–1290PubMed
6.
Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263–265PubMedCrossRef
7.
Benes FM, Lim B, Matzilevich D, Walsh JP, Subburaju S, Minns M (2007) Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars. Proc Natl Acad Sci USA 104:10164–10169PubMedCentralPubMedCrossRef
8.
Bethea CL, Reddy AP, Pedersen D, Tokuyama Y (2009) Expression profile of differentiating serotonin neurons derived from rhesus embryonic stem cells and comparison to adult serotonin neurons. Gene Expr Patterns 9:94–108PubMedCentralPubMedCrossRef
9.
Biederman J (1998) Attention-deficit/hyperactivity disorder: a life-span perspective. J Clin Psychiatry 59(Suppl 7):4–16PubMed
10.
Bonnet F, Perin JP, Charbonnier F, Camuzat A, Roussel G, Nussbaum JL, Alliel PM (1996) Structure and cellular distribution of mouse brain testican: association with the postsynaptic area of hippocampus pyramidal cells. J Biol Chem 271:4373–4380PubMedCrossRef
11.
Buga AM, Scholz CJ, Kumar S, Herndon JG, Alexandru D, Cojocaru GR, Dandekar T, Popa-Wagner A (2012) Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. PLoS ONE 7:e50985PubMedCentralPubMedCrossRef
12.
Cartharius K, Frech K, Grote K, Klocke B, Haltmeier M, Klingenhoff A, Frisch M, Bayerlein M, Werner T (2005) MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics 21:2933–2942PubMedCrossRef
13.
Coassin S, Brandstatter A, Kronenberg F (2010) Lost in the space of bioinformatic tools: a constantly updated survival guide for genetic epidemiology. The GenEpi Toolbox. Atherosclerosis 209:321–335PubMedCrossRef
14.
Coid J, Yang M, Tyrer P, Roberts A, Ullrich S (2006) Prevalence and correlates of personality disorder in Great Britain. Br J Psychiatry 188:423–431PubMedCrossRef
15.
Desmet FO, Hamroun D, Lalande M, Collod-Beroud G, Claustres M, Beroud C (2009) Human splicing finder: an online bioinformatics tool to predict splicing signals. Nucleic Acids Res 37:e67PubMedCentralPubMedCrossRef
16.
Dityatev A, Schachner M (2003) Extracellular matrix molecules and synaptic plasticity. Nat Rev Neurosci 4:456–468PubMedCrossRef
17.
Durston S, Fossella JA, Mulder MJ, Casey BJ, Ziermans TB, Vessaz MN, Van Engeland H (2008) Dopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation. J Am Acad Child Adolesc Psychiatry 47:61–67PubMedCrossRef
18.
Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57:1313–1323PubMedCrossRef
19.
Francius C, Clotman F (2010) Dynamic expression of the Onecut transcription factors HNF-6, OC-2 and OC-3 during spinal motor neuron development. Neuroscience 165:116–129PubMedCrossRef
20.
Franke B, Vasquez AA, Johansson S, Hoogman M, Romanos J, Boreatti-Hummer A, Heine M, Jacob CP, Lesch KP, Casas M, Ribases M, Bosch R, Sanchez-Mora C, Gomez-Barros N, Fernandez-Castillo N, Bayes M, Halmoy A, Halleland H, Landaas ET, Fasmer OB, Knappskog PM, Heister AJ, Kiemeney LA, Kooij JJ, Boonstra AM, Kan CC, Asherson P, Faraone SV, Buitelaar JK, Haavik J, Cormand B, Ramos-Quiroga JA, Reif A (2010) Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD. Neuropsychopharmacology 35:656–664PubMedCentralPubMedCrossRef
21.
Frazer KA, Ballinger DG, Cox DR, Hinds DA, Stuve LL, Gibbs RA, Belmont JW, Boudreau A, Hardenbol P, Leal SM, Pasternak S, Wheeler DA, Willis TD, Yu F, Yang H, Zeng C, Gao Y, Hu H, Hu W, Li C, Lin W, Liu S, Pan H, Tang X, Wang J, Wang W, Yu J, Zhang B, Zhang Q, Zhao H, Zhou J, Gabriel SB, Barry R, Blumenstiel B, Camargo A, Defelice M, Faggart M, Goyette M, Gupta S, Moore J, Nguyen H, Onofrio RC, Parkin M, Roy J, Stahl E, Winchester E, Ziaugra L, Altshuler D, Shen Y, Yao Z, Huang W, Chu X, He Y, Jin L, Liu Y, Sun W, Wang H, Wang Y, Xiong X, Xu L, Waye MM, Tsui SK, Xue H, Wong JT, Galver LM, Fan JB, Gunderson K, Murray SS, Oliphant AR, Chee MS, Montpetit A, Chagnon F, Ferretti V, Leboeuf M, Olivier JF, Phillips MS, Roumy S, Sallee C, Verner A, Hudson TJ, Kwok PY, Cai D, Koboldt DC, Miller RD, Pawlikowska L, Taillon-Miller P, Xiao M, Tsui LC, Mak W, Song YQ, Tam PK, Nakamura Y, Kawaguchi T, Kitamoto T, Morizono T, Nagashima A, Ohnishi Y, Sekine A, Tanaka T, Tsunoda T et al (2007) A second generation human haplotype map of over 3.1 million SNPs. Nature 449:851–861PubMedCrossRef
22.
Frazier JA, Hodge SM, Breeze JL, Giuliano AJ, Terry JE, Moore CM, Kennedy DN, Lopez-Larson MP, Caviness VS, Seidman LJ, Zablotsky B, Makris N (2008) Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophr Bull 34:37–46PubMedCentralPubMedCrossRef
23.
Harms MP, Wang L, Mamah D, Barch DM, Thompson PA, Csernansky JG (2007) Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings. J Neurosci 27:13835–13842PubMedCrossRef
24.
Hartmann U, Maurer P (2001) Proteoglycans in the nervous system—the quest for functional roles in vivo. Matrix Biol 20:23–35PubMedCrossRef
25.
Hiard S, Charlier C, Coppieters W, Georges M, Baurain D (2010) Patrocles: a database of polymorphic miRNA-mediated gene regulation in vertebrates. Nucleic Acids Res 38:D640–D651PubMedCentralPubMedCrossRef
26.
Iseki K, Hagino S, Zhang Y, Mori T, Sato N, Yokoya S, Hozumi Y, Goto K, Tase C (2011) Altered expression pattern of testican-1 mRNA after brain injury. Biomed Res 32:373–378PubMedCrossRef
27.
Jacob CP, Romanos J, Dempfle A, Heine M, Windemuth-Kieselbach C, Kruse A, Reif A, Walitza S, Romanos M, Strobel A, Brocke B, Schafer H, Schmidtke A, Boning J, Lesch KP (2007) Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center. Eur Arch Psychiatry Clin Neurosci 257:309–317PubMedCrossRef
28.
Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O’Donnell CJ, de Bakker PI (2008) SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 24:2938–2939PubMedCentralPubMedCrossRef
29.
Kessler RC, Adler L, Barkley R, Biederman J, Conners CK, Demler O, Faraone SV, Greenhill LL, Howes MJ, Secnik K, Spencer T, Ustun TB, Walters EE, Zaslavsky AM (2006) The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 163:716–723PubMedCentralPubMedCrossRef
30.
Lee BT, Seong Whi C, Hyung Soo K, Lee BC, Choi IG, Lyoo IK, Ham BJ (2007) The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 31:1487–1492PubMedCrossRef
31.
Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Roser C, Nguyen TT, Craig DW, Romanos J, Heine M, Meyer J, Freitag C, Warnke A, Romanos M, Schafer H, Walitza S, Reif A, Stephan DA, Jacob C (2008) Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 115:1573–1585PubMedCrossRef
32.
Li D, Sham PC, Owen MJ, He L (2006) Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 15:2276–2284PubMedCrossRef
33.
Ma J, Lei D, Jin X, Du X, Jiang F, Li F, Zhang Y, Shen X (2012) Compensatory brain activation in children with attention deficit/hyperactivity disorder during a simplified Go/No-go task. J Neural Transm 119:613–619PubMedCrossRef
34.
Marr HS, Basalamah MA, Bouldin TW, Duncan AW, Edgell CJ (2000) Distribution of testican expression in human brain. Cell Tissue Res 302:139–144PubMedCrossRef
35.
Marr HS, Edgell CJ (2003) Testican-1 inhibits attachment of Neuro-2a cells. Matrix Biol 22:259–266PubMedCrossRef
36.
37.
Nagayoshi T, Sanborn D, Hickok NJ, Olsen DR, Fazio MJ, Chu ML, Knowlton R, Mann K, Deutzmann R, Timpl R et al (1989) Human nidogen: complete amino acid sequence and structural domains deduced from cDNAs, and evidence for polymorphism of the gene. DNA 8:581–594PubMedCrossRef
38.
Nakada M, Yamada A, Takino T, Miyamori H, Takahashi T, Yamashita J, Sato H (2001) Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-Tes. Cancer Res 61:8896–8902PubMed
39.
Neale BM, Lasky-Su J, Anney R, Franke B, Zhou K, Maller JB, Vasquez AA, Asherson P, Chen W, Banaschewski T, Buitelaar J, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke E, Mulas F, Taylor E, Laird N, Lange C, Daly M, Faraone SV (2008) Genome-wide association scan of attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 147B:1337–1344PubMedCentralPubMedCrossRef
40.
Novak U, Kaye AH (2000) Extracellular matrix and the brain: components and function. J Clin Neurosci 7:280–290PubMedCrossRef
41.
Ossovskaya VS, Dolganov G, Basbaum AI (2009) Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth. J Neurosci Methods 177:322–333PubMedCrossRef
42.
Pantelis C, Barnes TR, Nelson HE, Tanner S, Weatherley L, Owen AM, Robbins TW (1997) Frontal–striatal cognitive deficits in patients with chronic schizophrenia. Brain 120(Pt 10):1823–1843PubMedCrossRef
43.
Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164:942–948PubMedCrossRef
44.
Puelles E, Acampora D, Gogoi R, Tuorto F, Papalia A, Guillemot F, Ang SL, Simeone A (2006) Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation. J Neurosci 26:5955–5964PubMedCrossRef
45.
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559–575PubMedCentralPubMedCrossRef
46.
Rathinam C, Geffers R, Yucel R, Buer J, Welte K, Moroy T, Klein C (2005) The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and function. Immunity 22:717–728PubMedCrossRef
47.
Reif A, Nguyen TT, Weissflog L, Jacob CP, Romanos M, Renner TJ, Buttenschon HN, Kittel-Schneider S, Gessner A, Weber H, Neuner M, Gross-Lesch S, Zamzow K, Kreiker S, Walitza S, Meyer J, Freitag CM, Bosch R, Casas M, Gomez N, Ribases M, Bayes M, Buitelaar JK, Kiemeney LA, Kooij JJ, Kan CC, Hoogman M, Johansson S, Jacobsen KK, Knappskog PM, Fasmer OB, Asherson P, Warnke A, Grabe HJ, Mahler J, Teumer A, Volzke H, Mors ON, Schafer H, Ramos-Quiroga JA, Cormand B, Haavik J, Franke B, Lesch KP (2011) DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders. Neuropsychopharmacology 36:2318–2327PubMedCentralPubMedCrossRef
48.
Röll S (2004) Untersuchungen zur Funktion von Testicanen; Generierung von Testican-1 und -3 defizienten Mauslinien. In:Universität Köln
49.
Roll S, Seul J, Paulsson M, Hartmann U (2006) Testican-1 is dispensable for mouse development. Matrix Biol 25:373–381PubMedCrossRef
50.
Schimmelmann BG, Friedel S, Christiansen H, Dempfle A, Hinney A, Hebebrand J (2006) Genetic findings in attention-deficit and hyperactivity disorder (ADHD). Z Kinder Jugendpsychiatr Psychother 34:425–433PubMedCrossRef
51.
Schnepp A, Komp Lindgren P, Hulsmann H, Kroger S, Paulsson M, Hartmann U (2005) Mouse testican-2: expression, glycosylation, and effects on neurite outgrowth. J Biol Chem 280:11274–11280PubMedCrossRef
52.
Shimasaki S, Gao L, Shimonaka M, Ling N (1991) Isolation and molecular cloning of insulin-like growth factor-binding protein-6. Mol Endocrinol 5:938–948PubMedCrossRef
53.
Simeone A, Di Salvio M, Di Giovannantonio LG, Acampora D, Omodei D, Tomasetti C (2011) The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons. Mol Neurobiol 43:107–113PubMedCrossRef
54.
Subburaju S, Benes FM (2012) Induction of the GABA cell phenotype: an in vitro model for studying neurodevelopmental disorders. PLoS ONE 7:e33352PubMedCentralPubMedCrossRef
55.
Takahata T, Komatsu Y, Watakabe A, Hashikawa T, Tochitani S, Yamamori T (2009) Differential expression patterns of occ1-related genes in adult monkey visual cortex. Cereb Cortex 19:1937–1951PubMedCentralPubMedCrossRef
56.
Wang N, Akey JM, Zhang K, Chakraborty R, Jin L (2002) Distribution of recombination crossovers and the origin of haplotype blocks: the interplay of population history, recombination, and mutation. Am J Hum Genet 71:1227–1234PubMedCentralPubMedCrossRef
57.
Weber H, Scholz CJ, Domschke K, Baumann C, Klauke B, Jacob CP, Maier W, Fritze J, Bandelow B, Zwanzger PM, Lang T, Fehm L, Strohle A, Hamm A, Gerlach AL, Alpers GW, Kircher T, Wittchen HU, Arolt V, Pauli P, Deckert J, Reif A (2012) Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder. PLoS ONE 7:e37651PubMedCentralPubMedCrossRef
58.
Weissflog L, Scholz CJ, Jacob CP, Nguyen TT, Zamzow K, Gross-Lesch S, Renner TJ, Romanos M, Rujescu D, Walitza S, Kneitz S, Lesch KP, Reif A (2012) KCNIP4 as a candidate gene for personality disorders and adult ADHD. Eur Neuropsychopharmacol 23(6):436–447
59.
Westendorf JJ, Zaidi SK, Cascino JE, Kahler R, van Wijnen AJ, Lian JB, Yoshida M, Stein GS, Li X (2002) Runx2 (Cbfa1, AML-3) interacts with histone deacetylase 6 and represses the p21(CIP1/WAF1) promoter. Mol Cell Biol 22:7982–7992PubMedCentralPubMedCrossRef
Metadaten
Titel
SPOCK3, a risk gene for adult ADHD and personality disorders
verfasst von
Heike Weber
Claus-Jürgen Scholz
Christian P. Jacob
Julia Heupel
Sarah Kittel-Schneider
Angelika Erhardt
Susanne Hempel
Brigitte Schmidt
Tilman Kiel
Alexandra Gessner
Klaus-Peter Lesch
Andreas Reif
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 5/2014
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-013-0476-2

Weitere Artikel der Ausgabe 5/2014

European Archives of Psychiatry and Clinical Neuroscience 5/2014 Zur Ausgabe

Original Paper

Influence of differentially expressed genes from suicide post-mortem study on personality traits as endophenotypes on healthy subjects and suicide attempters

Original Paper

Do features of Mozart’s letter-writing style indicate the presence of a neuropsychiatric disorder? Controversies about the Bäsle letters

Original Paper

Adult attention-deficit/hyperactivity disorder in major depressed and bipolar subjects: role of personality traits and clinical implications

Short Communication

Fatty acid ethanolamide levels are altered in borderline personality and complex posttraumatic stress disorders

Original Paper

Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults

Original Paper

Memories of attachment hamper EEG cortical connectivity in dissociative patients

Neu im Fachgebiet Psychiatrie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Antihypertensiva schützen auch alte Menschen noch vor Demenz

17.04.2024 | Delir nicht substanzbedingt | Nachrichten

Delir kann Demenz begünstigen

16.04.2024 | Störungen der Geschlechtsidentität | Nachrichten

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

12.04.2024 | Vitiligo | Nachrichten

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt
weitere anzeigen

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen