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Erschienen in: Rheumatology International 5/2008

01.03.2008 | Case Report

Spontaneous regression of EBV-associated diffuse lymphoproliferative disease in a patient with rheumatoid arthritis after discontinuation of etanercept treatment

verfasst von: Sung-Hoon Park, Chae-Gi Kim, Ji-Young Kim, Jung-Yoon Choe

Erschienen in: Rheumatology International | Ausgabe 5/2008

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Abstract

We describe the case of a 64-year-old female patient with rheumatoid arthritis (RA), who presented with lymphoproliferative disease (LPD) soon after the administration of etanercept, and regressed very shortly after the withdrawal of it. The occurrence was also associated with the Epstein–Barr virus (EBV) infection. The case of our patient may provide the evidence that etanercept plays an etiologic role in LPD in patients with RA.
Literatur
1.
Zurück zum Zitat Ekbom A (2005) Epidemiology of lymphoma development in patients with rheumatoid arthritis. Semin Arthritis Rheum 34:28–30PubMedCrossRef Ekbom A (2005) Epidemiology of lymphoma development in patients with rheumatoid arthritis. Semin Arthritis Rheum 34:28–30PubMedCrossRef
2.
Zurück zum Zitat Baecklund E, Askling J, Rosenquist R, Ekbom A, Klareskog L (2004) Rheumatoid arthritis and malignant lymphomas. Curr Opin Rheumatol 16:254–261PubMedCrossRef Baecklund E, Askling J, Rosenquist R, Ekbom A, Klareskog L (2004) Rheumatoid arthritis and malignant lymphomas. Curr Opin Rheumatol 16:254–261PubMedCrossRef
3.
Zurück zum Zitat Baecklund E, Iliadou A, Askling J (2006) Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54:692–701PubMedCrossRef Baecklund E, Iliadou A, Askling J (2006) Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum 54:692–701PubMedCrossRef
4.
Zurück zum Zitat Hoshida Y, Xu JX, Fujita S (2007) Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34:322–331PubMed Hoshida Y, Xu JX, Fujita S (2007) Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication. J Rheumatol 34:322–331PubMed
5.
Zurück zum Zitat Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295:2275–2285PubMedCrossRef Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V (2006) Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 295:2275–2285PubMedCrossRef
6.
Zurück zum Zitat Geborek P, Bladstrom A, Turesson C (2005) Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas. Ann Rheum Dis 64:699–703PubMedCrossRef Geborek P, Bladstrom A, Turesson C (2005) Tumour necrosis factor blockers do not increase overall tumour risk in patients with rheumatoid arthritis, but may be associated with an increased risk of lymphomas. Ann Rheum Dis 64:699–703PubMedCrossRef
7.
Zurück zum Zitat Wolfe F, Michaud K (2007) The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum 56:1433–1439PubMedCrossRef Wolfe F, Michaud K (2007) The effect of methotrexate and anti-tumor necrosis factor therapy on the risk of lymphoma in rheumatoid arthritis in 19,562 patients during 89,710 person-years of observation. Arthritis Rheum 56:1433–1439PubMedCrossRef
8.
Zurück zum Zitat Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50:1740–1751PubMedCrossRef Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50:1740–1751PubMedCrossRef
9.
Zurück zum Zitat Miyazaki T, Fujimaki K, Shirasugi Y (2007) Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: relationship with type of latent Epstein–Barr virus infection. Am J Hematol (in press) Miyazaki T, Fujimaki K, Shirasugi Y (2007) Remission of lymphoma after withdrawal of methotrexate in rheumatoid arthritis: relationship with type of latent Epstein–Barr virus infection. Am J Hematol (in press)
10.
Zurück zum Zitat Starkebaum G (2007) Rheumatoid arthritis and lymphoma: risky business for B cells. J Rheumatol 34:243–246PubMed Starkebaum G (2007) Rheumatoid arthritis and lymphoma: risky business for B cells. J Rheumatol 34:243–246PubMed
11.
Zurück zum Zitat Thonhofer R, Gaugg M, Kriessmayr M, Neumann HJ, Erlacher L (2005) Spontaneous remission of marginal zone B cell lymphoma in a patient with seropositive rheumatoid arthritis after discontinuation of infliximab-methotrexate treatment. Ann Rheum Dis 64:1098–1099PubMedCrossRef Thonhofer R, Gaugg M, Kriessmayr M, Neumann HJ, Erlacher L (2005) Spontaneous remission of marginal zone B cell lymphoma in a patient with seropositive rheumatoid arthritis after discontinuation of infliximab-methotrexate treatment. Ann Rheum Dis 64:1098–1099PubMedCrossRef
12.
Zurück zum Zitat Quartuccio L, De Re V, Fabris M (2006) Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization. Haematologica 91:691–694PubMed Quartuccio L, De Re V, Fabris M (2006) Atypical lymphoproliferation progressing into B-cell lymphoma in rheumatoid arthritis treated with different biological agents: clinical course and molecular characterization. Haematologica 91:691–694PubMed
13.
Zurück zum Zitat Okano M, Gross TG (2000) A review of Epstein–Barr virus infection in patients with immunodeficiency disorders. Am J Med Sci 319:392–396PubMedCrossRef Okano M, Gross TG (2000) A review of Epstein–Barr virus infection in patients with immunodeficiency disorders. Am J Med Sci 319:392–396PubMedCrossRef
14.
Zurück zum Zitat Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 311:1471–1475PubMedCrossRef Horning SJ, Rosenberg SA (1984) The natural history of initially untreated low-grade non-Hodgkin’s lymphomas. N Engl J Med 311:1471–1475PubMedCrossRef
Metadaten
Titel
Spontaneous regression of EBV-associated diffuse lymphoproliferative disease in a patient with rheumatoid arthritis after discontinuation of etanercept treatment
verfasst von
Sung-Hoon Park
Chae-Gi Kim
Ji-Young Kim
Jung-Yoon Choe
Publikationsdatum
01.03.2008
Verlag
Springer-Verlag
Erschienen in
Rheumatology International / Ausgabe 5/2008
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-007-0467-6

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