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Erschienen in:
01.02.2011 | Clinical and Epidemiological Study
A meta-analysis of the relation of polymorphism at sites −1082 and −592 of the IL-10 gene promoter with susceptibility and clearance to persistent hepatitis B virus infection in the Chinese population
Erschienen in: Infection | Ausgabe 1/2011
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Background
Up to now, many publications about the Chinese population have evaluated the correlation between interleukin-10 (IL-10) −1082 and −592 polymorphisms and persistent hepatitis B virus (HBV) infection. However, the results remain inconclusive. In order to resolve this conflict, a meta-analysis was performed.
Methods
Seven studies were included and dichotomous data are presented as the odds ratio (OR) with a 95% confidence interval (CI).
Results
The results of our study suggest that carriers of the IL-10 −592A allele were more likely to clear HBV spontaneously in the Chinese pooled population (A vs. C: OR = 0.799, 95% CI = 0.678–0.941, P = 0.007; AC vs. AA: OR = 1.343, 95% CI = 1.017–1.684, P = 0.011; AA vs. AC + CC: OR = 0.736, 95% CI = 0.594–0.912; AA + AC vs. CC: OR = 0.588, 95% CI = 0.408–0.848, P = 0.004) and the IL-10 −1082A allele was associated with significantly reduced persistent HBV infection risk in Chinese (A vs. G: OR = 0.701, 95% CI = 0.494–0.996, P = 0.047; AA vs. GG + GA: OR = 0.684, 95% CI = 0.476–0.982, P = 0.040).
Conclusions
Persistent HBV infection susceptibility is associated with the gene polymorphism IL-10 −1082GA in the Chinese population and the clearance of HBV is associated with the gene polymorphism IL-10 −592CA in the Chinese population.