Ausgabe 1/2019
Inhalt (112 Artikel)
Alcohol use and dementia: a systematic scoping review
Jürgen Rehm, Omer S. M. Hasan, Sandra E. Black, Kevin D. Shield, Michaël Schwarzinger
Erlangen Score as a tool to predict progression from mild cognitive impairment to dementia in Alzheimer’s disease
Inês Baldeiras, Isabel Santana, Maria João Leitão, Daniela Vieira, Diana Duro, Barbara Mroczko, Johannes Kornhuber, Piotr Lewczuk
The quest for synergy between physical exercise and cognitive stimulation via exergaming in people with dementia: a randomized controlled trial
Esther G. A. Karssemeijer, Justine A. Aaronson, Willem J. R. Bossers, Rogier Donders, Marcel G. M. Olde Rikkert, Roy P. C. Kessels
Measuring instrumental activities of daily living in non-demented elderly: a comparison of the new performance-based Harvard Automated Phone Task with other functional assessments
Gad A. Marshall, Sarah L. Aghjayan, Maria Dekhtyar, Joseph J. Locascio, Kamal Jethwani, Rebecca E. Amariglio, Sara J. Czaja, David A. Loewenstein, Keith A. Johnson, Reisa A. Sperling, Dorene M. Rentz
Genome-wide analysis of genetic predisposition to Alzheimer’s disease and related sex disparities
Alireza Nazarian, Anatoliy I. Yashin, Alexander M. Kulminski
CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice
Wai Hang Cheng, Kris M. Martens, Asma Bashir, Honor Cheung, Sophie Stukas, Ebrima Gibbs, Dhananjay R. Namjoshi, Emily B. Button, Anna Wilkinson, Carlos J. Barron, Neil R. Cashman, Peter A. Cripton, Cheryl L. Wellington
Prevalence and risk of progression of preclinical Alzheimer’s disease stages: a systematic review and meta-analysis
Lucilla Parnetti, Elena Chipi, Nicola Salvadori, Katia D’Andrea, Paolo Eusebi
Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples
Steffen Wolfsgruber, José Luis Molinuevo, Michael Wagner, Charlotte E. Teunissen, Lorena Rami, Nina Coll-Padrós, Femke H. Bouwman, Rosalinde E. R. Slot, Linda M. P. Wesselman, Oliver Peters, Katja Luther, Katharina Buerger, Josef Priller, Christoph Laske, Stefan Teipel, Annika Spottke, Michael T. Heneka, Emrah Düzel, Alexander Drzezga, Jens Wiltfang, Sietske A. M. Sikkes, Wiesje M. van der Flier, Frank Jessen
Consecutive sessions of transcranial direct current stimulation do not remediate visual hallucinations in Lewy body dementia: a randomised controlled trial
Greg J. Elder, Sean J. Colloby, Michael J. Firbank, Ian G. McKeith, John-Paul Taylor
Data-driven prognostic features of cognitive trajectories in patients with amnestic mild cognitive impairments
Yeo Jin Kim, Seong-Kyoung Cho, Hee Jin Kim, Jin San Lee, Juyoun Lee, Young Kyoung Jang, Jacob W. Vogel, Duk L. Na, Changsoo Kim, Sang Won Seo
Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study
Anette Hall, Timo Pekkala, Tuomo Polvikoski, Mark van Gils, Miia Kivipelto, Jyrki Lötjönen, Jussi Mattila, Mia Kero, Liisa Myllykangas, Mira Mäkelä, Minna Oinas, Anders Paetau, Hilkka Soininen, Maarit Tanskanen, Alina Solomon
Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort
Gemma Salvadó, Anna Brugulat-Serrat, Carole H. Sudre, Oriol Grau-Rivera, Marc Suárez-Calvet, Carles Falcon, Karine Fauria, M. Jorge Cardoso, Frederik Barkhof, José Luis Molinuevo, Juan Domingo Gispert, Jordi Camí, Albina Polo, Cristina Mustata, Laia Tenas, Paula Marne, Xavi Gotsens, Tania Menchón, Anna Soteras, Laura Hernandez, Ruth Dominguez, Sandra Prades, Raffaele Cacciaglia, Grégory Operto, Stavros Skouras, Gonzalo Sánchez, Carolina Minguillón, Gema Huesa, Marc Vilanova, Sabrina Segundo, Jordi Huget
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
Richard M. Tsai, Alexandre Bejanin, Orit Lesman-Segev, Renaud LaJoie, Adrienne Visani, Viktoriya Bourakova, James P. O’Neil, Mustafa Janabi, Suzanne Baker, Suzee E. Lee, David C. Perry, Lynn Bajorek, Anna Karydas, Salvatore Spina, Lea T. Grinberg, William W. Seeley, Eliana M. Ramos, Giovanni Coppola, Maria Luisa Gorno-Tempini, Bruce L. Miller, Howard J. Rosen, William Jagust, Adam L. Boxer, Gil D. Rabinovici
Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer’s disease
Omar A. Halawa, Jennifer R. Gatchel, Rebecca E. Amariglio, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Gad A. Marshall
Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study
Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois, Harald Hampel, Hovagim Bakardjian, Habib Benali, Hugo Bertin, Joel Bonheur, Laurie Boukadida, Nadia Boukerrou, Enrica Cavedo, Patrizia Chiesa, Olivier Colliot, Bruno Dubois, Marion Dubois, Stéphane Epelbaum, Geoffroy Gagliardi, Remy Genthon, Marie-Odile Habert, Harald Hampel, Marion Houot, Aurélie Kas, Foudil Lamari, Marcel Levy, Simone Lista, Christiane Metzinger, Fanny Mochel, Francis Nyasse, Catherine Poisson, Marie-Claude Potier, Marie Revillon, Antonio Santos, Katia Santos Andrade, Marine Sole, Mohmed Surtee, Michel Thiebaud de Schotten, Andrea Vergallo, Nadjia Younsi, Lisi Flores Aguilar, Claudio Babiloni, Filippo Baldacci, Norbert Benda, Keith L. Black, Arun L. W. Bokde, Ubaldo Bonuccelli, Karl Broich, René S. Bun, Francesco Cacciola, Juan Castrillo, Enrica Cavedo, Roberto Ceravolo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman, Jean-Christophe Corvol, Augusto Claudio Cuello, Jeffrey L. Cummings, Herman Depypere, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Valentina Escott-Price, Howard Federoff, Maria Teresa Ferretti, Massimo Fiandaca, Richard A. Frank, Francesco Garaci, Remy Genthon, Nathalie George, Filippo S. Giorgi, Manuela Graziani, Marion Haberkamp, Marie-Odile Habert, Harald Hampel, Karl Herholz, Eric Karran, Seung H. Kim, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Simone Lista, Jean Lorenceau, Mark Mapstone, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Sid E. O’bryant, George Perry, Craig Ritchie, Katrine Rojkova, Simone Rossi, Amira Saidi, Emiliano Santarnecchi, Lon S. Schneider, Olaf Sporns, Nicola Toschi, Steven R. Verdooner, Andrea Vergallo, Nicolas Villain, Lindsay A. Welikovitch, Janet Woodcock, Erfan Younesi
Alzheimer’s disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph
Lorenza Magno, Christian B. Lessard, Marta Martins, Verena Lang, Pedro Cruz, Yasmine Asi, Matilda Katan, Jamie Bilsland, Tammaryn Lashley, Paramita Chakrabarty, Todd E. Golde, Paul J. Whiting
Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer’s disease
Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Daniel J. Norton, Edmarie Guzman-Velez, Ana Baena, Enmanuelle Pardilla-Delgado, Aaron P. Schultz, Jennifer Gatchel, David Jin, Kewei Chen, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz
Evaluation of the efficacy, safety and tolerability of orally administered BI 409306, a novel phosphodiesterase type 9 inhibitor, in two randomised controlled phase II studies in patients with prodromal and mild Alzheimer’s disease
Lutz Frölich, Glen Wunderlich, Claus Thamer, Michael Roehrle, Miguel Garcia Jr, Bruno Dubois
Longitudinal measurement of serum neurofilament light in presymptomatic familial Alzheimer’s disease
Philip S. J. Weston, Teresa Poole, Antoinette O’Connor, Amanda Heslegrave, Natalie S. Ryan, Yuying Liang, Ronald Druyeh, Simon Mead, Kaj Blennow, Jonathan M. Schott, Chris Frost, Henrik Zetterberg, Nick C. Fox
Brain glucose metabolism in Lewy body dementia: implications for diagnostic criteria
Silvia Paola Caminiti, Arianna Sala, Leonardo Iaccarino, Luca Beretta, Andrea Pilotto, Luigi Gianolli, Sandro Iannaccone, Giuseppe Magnani, Alessandro Padovani, Luigi Ferini-Strambi, Daniela Perani
Brief cognitive screening instruments for early detection of Alzheimer’s disease: a systematic review
Ellen Elisa De Roeck, Peter Paul De Deyn, Eva Dierckx, Sebastiaan Engelborghs
Concepts for brain aging: resistance, resilience, reserve, and compensation
Thomas J. Montine, Brenna A. Cholerton, Maria M. Corrada, Steven D. Edland, Margaret E. Flanagan, Laura S. Hemmy, Claudia H. Kawas, Lon R. White
Lewy Body Dementia Association’s Research Centers of Excellence Program: Inaugural Meeting Proceedings
Bethany Peterson, Melissa Armstrong, Douglas Galasko, James E. Galvin, Jennifer Goldman, David Irwin, Henry Paulson, Daniel Kaufer, James Leverenz, Angela Lunde, Ian G. McKeith, Andrew Siderowf, Angela Taylor, Katherine Amodeo, Matt Barrett, Kimiko Domoto-Reilly, John Duda, Stephen Gomperts, Neill Graff-Radford, Samantha Holden, Lawrence Honig, Daniel Huddleston, Carol Lippa, Irene Litvan, Carol Manning, Karen Marder, Charbel Moussa, Chiadi Onyike, Fernando Pagan, Alexander Pantelyat, Victoria Pelak, Kathleen Poston, Joseph Quinn, Irene Richard, Liana S. Rosenthal, Marwan Sabbagh, Douglas Scharre, Sharon Sha, Holly Shill, Yasar Torres-Yaghi, Tina Christie, Todd Graham, Ian Richards, Mike Koehler, Brad Boeve
Reversible predictors of reversion from mild cognitive impairment to normal cognition: a 4-year longitudinal study
Hiroyuki Shimada, Takehiko Doi, Sangyoon Lee, Hyuma Makizako
Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study
Marie Bruun, Kristian S. Frederiksen, Hanneke F. M. Rhodius-Meester, Marta Baroni, Le Gjerum, Juha Koikkalainen, Timo Urhemaa, Antti Tolonen, Mark van Gils, Daniel Rueckert, Nadia Dyremose, Birgitte B. Andersen, Afina W. Lemstra, Merja Hallikainen, Sudhir Kurl, Sanna-Kaisa Herukka, Anne M. Remes, Gunhild Waldemar, Hilkka Soininen, Patrizia Mecocci, Wiesje M. van der Flier, Jyrki Lötjönen, Steen G. Hasselbalch
Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer’s disease
Carla M. Startin, Nicholas J. Ashton, Sarah Hamburg, Rosalyn Hithersay, Frances K. Wiseman, Kin Y. Mok, John Hardy, Alberto Lleó, Simon Lovestone, Lucilla Parnetti, Henrik Zetterberg, Abdul Hye, Andre Strydom, Elizabeth Fisher, Dean Nizetic, John Hardy, Victor Tybulewicz, Annette Karmiloff-Smith, Tamara Al-Janabi, David Zhang, André Strydom
Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
Gemma Salvadó, José Luis Molinuevo, Anna Brugulat-Serrat, Carles Falcon, Oriol Grau-Rivera, Marc Suárez-Calvet, Javier Pavia, Aida Niñerola-Baizán, Andrés Perissinotti, Francisco Lomeña, Carolina Minguillon, Karine Fauria, Henrik Zetterberg, Kaj Blennow, Juan Domingo Gispert, Jordi Camí, Raffaele Cacciaglia, Marta Crous-Bou, Carme Deulofeu, Ruth Dominguez, Xavi Gotsens, Nina Gramunt, Laura Hernandez, Gema Huesa, Jordi Huguet, María León, Paula Marne, Tania Menchón, Marta Milà, Grégory Operto, Maria Pascual, Albina Polo, Sandra Pradas, Aleix Sala-Vila, Gonzalo Sánchez-Benavides, Sabrina Segundo, Anna Soteras, Laia Tenas, Marc Vilanova, Natalia Vilor-Tejedor
Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease
Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan, Qing-Rong Liu
CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease
Adla Boumenir, Emmanuel Cognat, Severine Sabia, Claire Hourregue, Matthieu Lilamand, Aline Dugravot, Elodie Bouaziz-Amar, Jean-Louis Laplanche, Jacques Hugon, Archana Singh-Manoux, Claire Paquet, Julien Dumurgier
Phenocopy syndrome of behavioral variant frontotemporal dementia: a systematic review
Elizabeth Sakamoto Valente, Paulo Caramelli, Leandro Boson Gambogi, Luciano Inácio Mariano, Henrique Cerqueira Guimarães, Antônio Lúcio Teixeira, Leonardo Cruz de Souza
Risk of dementia in patients with end-stage renal disease under maintenance dialysis—a nationwide population-based study with consideration of competing risk of mortality
Yi-Ting Kuo, Chung-Yi Li, Junne-Ming Sung, Chiung-Chih Chang, Jung-Der Wang, Chien-Yao Sun, Jia-Ling Wu, Yu-Tzu Chang
Risk of suicide and accidental deaths among elderly patients with cognitive impairment
Ji Hyun An, Kyung Eun Lee, Hong Jin Jeon, Sang Joon Son, Sung Yoon Kim, Jin Pyo Hong
Personalized risk for clinical progression in cognitively normal subjects—the ABIDE project
Ingrid S. van Maurik, Rosalinde E. R. Slot, Sander C. J. Verfaillie, Marissa D. Zwan, Femke H. Bouwman, Niels D. Prins, Charlotte E. Teunissen, Philip Scheltens, Frederik Barkhof, Mike P. Wattjes, Jose Luis Molinuevo, Lorena Rami, Steffen Wolfsgruber, Oliver Peters, Frank Jessen, Johannes Berkhof, Wiesje M. van der Flier
Advantages and disadvantages of the use of the CSF Amyloid β (Aβ) 42/40 ratio in the diagnosis of Alzheimer’s Disease
Oskar Hansson, Sylvain Lehmann, Markus Otto, Henrik Zetterberg, Piotr Lewczuk
Exposure to fluoride aggravates the impairment in learning and memory and neuropathological lesions in mice carrying the APP/PS1 double-transgenic mutation
Kun Cao, Jie Xiang, Yang-Ting Dong, Yi Xu, Yi Li, Hui Song, Xiao-Xiao Zeng, Long-Yan Ran, Wei Hong, Zhi-Zhong Guan
Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial
Miranka Wirth, Claudia Schwarz, Gloria Benson, Nora Horn, Ralph Buchert, Catharina Lange, Theresa Köbe, Stefan Hetzer, Marta Maglione, Eva Michael, Stefanie Märschenz, Knut Mai, Ute Kopp, Dietmar Schmitz, Ulrike Grittner, Stephan J. Sigrist, Slaven Stekovic, Frank Madeo, Agnes Flöel
Safety and tolerability of donepezil 23 mg with or without intermediate dose titration in patients with Alzheimer’s disease taking donepezil 10 mg: a multicenter, randomized, open-label, parallel-design, three-arm, prospective trial
Yun Jeong Hong, Hyun Jeong Han, Young Chul Youn, Kyung Won Park, Dong Won Yang, SangYun Kim, Hwa Jung Kim, Ji Eun Kim, Jae-Hong Lee
Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer’s disease
Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M. Landau, Bente Finsen
Correction to: Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease
Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan, Qing-Rong Liu
Blood amyloid-β oligomerization associated with neurodegeneration of Alzheimer’s disease
Young Chul Youn, Sungmin Kang, Jeewon Suh, Young Ho Park, Min Ju Kang, Jung-Min Pyun, Seong Hye Choi, Jee Hyang Jeong, Kyung Won Park, Ho-Won Lee, Seong Soo A. An, Jacqueline C. Dominguez, SangYun Kim
Segmentation of medial temporal subregions reveals early right-sided involvement in semantic variant PPA
Martina Bocchetta, Juan Eugenio Iglesias, Lucy L. Russell, Caroline V. Greaves, Charles R. Marshall, Marzia A. Scelsi, David M. Cash, Sebastien Ourselin, Jason D. Warren, Jonathan D. Rohrer
Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice
Sofía Fernández de Retana, Paula Marazuela, Montse Solé, Guillem Colell, Anna Bonaterra, Jose Luis Sánchez-Quesada, Joan Montaner, Daniel Maspoch, Mary Cano-Sarabia, Mar Hernández-Guillamon
Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study
Maryam Yahiaoui-Doktor, Tobias Luck, Steffi G. Riedel-Heller, Markus Loeffler, Kerstin Wirkner, Christoph Engel
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
Emily B. Button, Guilaine K. Boyce, Anna Wilkinson, Sophie Stukas, Arooj Hayat, Jianjia Fan, Brennan J. Wadsworth, Jerome Robert, Kris M. Martens, Cheryl L. Wellington
Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort
Roos J. Jutten, John E. Harrison, Philippe R. Lee Meeuw Kjoe, Silvia Ingala, R. Vreeswijk, R. A. J. van Deelen, Frank Jan de Jong, Esther M. Opmeer, André Aleman, Craig W. Ritchie, Philip Scheltens, Sietske A. M. Sikkes
Altered microRNAs related to synaptic function as potential plasma biomarkers for Alzheimer’s disease
Dolores Siedlecki-Wullich, Judit Català-Solsona, Cristina Fábregas, Isabel Hernández, Jordi Clarimon, Alberto Lleó, Merce Boada, Carlos A. Saura, José Rodríguez-Álvarez, Alfredo J. Miñano-Molina
The association of vascular disorders with incident dementia in different age groups
Nienke Legdeur, Sven J. van der Lee, Marcel de Wilde, Johan van der Lei, Majon Muller, Andrea B. Maier, Pieter Jelle Visser
Early recognition and treatment of neuropsychiatric symptoms to improve quality of life in early Alzheimer’s disease: protocol of the BEAT-IT study
Willem S. Eikelboom, Ellen Singleton, Esther van den Berg, Michiel Coesmans, Francesco Mattace Raso, Rozemarijn L. van Bruchem, Jeannette A. Goudzwaard, Frank Jan de Jong, Marc Koopmanschap, Tom den Heijer, Jan J. M. Driesen, Lilian J. H. M. Vroegindeweij, Elsbeth C. Thomeer, Susanne E. Hoogers, Anke A. Dijkstra, Sytse U. Zuidema, Yolande A. L. Pijnenburg, Philip Scheltens, John C. van Swieten, Rik Ossenkoppele, Janne M. Papma
Electrophysiological brain signatures for the classification of subjective cognitive decline: towards an individual detection in the preclinical stages of dementia
David López-Sanz, Ricardo Bruña, María Luisa Delgado-Losada, Ramón López-Higes, Alberto Marcos-Dolado, Fernando Maestú, Stefan Walter
Anxiety correlates with cortical surface area in subjective cognitive decline: APOE ε4 carriers versus APOE ε4 non-carriers
Yu Sun, Xiaoni Wang, Yinshan Wang, Haoming Dong, Jie Lu, Tohar Scheininger, Michael Ewers, Frank Jessen, Xi-Nian Zuo, Ying Han
Response to “Avoiding Methodological Bias in Studies of Amyloid Imaging Results Disclosure”
Joshua D. Grill, Chelsea G. Cox, Kristin Harkins, Jason Karlawish
Avoiding methodological bias in studies of amyloid imaging results disclosure
Carl Taswell, Cheryl Donohue, Maree T. Mastwyk, Andrea G. Louey, Jacqueline Giummarra, Joanne Robertson, David G. Darby, Colin L. Masters, Christopher C. Rowe
Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lötjönen, Esko Levälahti, Riitta Parkkola, Pauliina Pippola, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Miia Kivipelto, Hilkka Soininen, Alina Solomon
Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer’s disease
Si Zhang, Jiehao Zhao, Yuhu Zhang, Yun Zhang, Fang Cai, Lijuan Wang, Weihong Song
Frailty effects on non-demented cognitive trajectories are moderated by sex and Alzheimer’s genetic risk
Sherilyn Thibeau, Kirstie McDermott, G. Peggy McFall, Kenneth Rockwood, Roger A. Dixon
Human amyloid-β enriched extracts: evaluation of in vitro and in vivo internalization and molecular characterization
Cristina M. Pedrero-Prieto, Alicia Flores-Cuadrado, Daniel Saiz-Sánchez, Isabel Úbeda-Bañón, Javier Frontiñán-Rubio, Francisco J. Alcaín, Lourdes Mateos-Hernández, José de la Fuente, Mario Durán-Prado, Margarita Villar, Alino Martínez-Marcos, Juan R. Peinado
FDG-PET as an independent biomarker for Alzheimer’s biological diagnosis: a longitudinal study
Ya-Nan Ou, Wei Xu, Jie-Qiong Li, Yu Guo, Mei Cui, Ke-Liang Chen, Yu-Yuan Huang, Qiang Dong, Lan Tan, Jin-Tai Yu
Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response
Leslie A. Sandusky-Beltran, Andrii Kovalenko, Chao Ma, John Ivan T. Calahatian, Devon S. Placides, Mallory D. Watler, Jerry B. Hunt, April L. Darling, Jeremy D. Baker, Laura J. Blair, Mackenzie D. Martin, Sarah N. Fontaine, Chad A. Dickey, April L. Lussier, Edwin J. Weeber, Maj-Linda B. Selenica, Kevin R. Nash, Marcia N. Gordon, Dave Morgan, Daniel C. Lee
An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development
Abhinaba Ghosh, Sarah E. Torraville, Bandhan Mukherjee, Susan G. Walling, Gerard M. Martin, Carolyn W. Harley, Qi Yuan
Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum
Tessa Timmers, Rik Ossenkoppele, Emma E. Wolters, Sander C. J. Verfaillie, Denise Visser, Sandeep S. V. Golla, Frederik Barkhof, Philip Scheltens, Ronald Boellaard, Wiesje M. van der Flier, Bart N. M. van Berckel
Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time
Elizabeth Kuhn, Inès Moulinet, Audrey Perrotin, Renaud La Joie, Brigitte Landeau, Clémence Tomadesso, Alexandre Bejanin, Siya Sherif, Vincent De La Sayette, Béatrice Desgranges, Denis Vivien, Géraldine Poisnel, Gaëlle Chételat
Retinal thickness as potential biomarker in posterior cortical atrophy and typical Alzheimer’s disease
Jurre den Haan, Lajos Csinscik, Tom Parker, Ross W. Paterson, Catherine F. Slattery, Alexander Foulkes, Femke H. Bouwman, Frank D. Verbraak, Philip Scheltens, Tunde Peto, Imre Lengyel, Jonathan M. Schott, Sebastian J. Crutch, Timothy J. Shakespeare, Keir X. X. Yong
Towards a unified protocol for handling of CSF before β-amyloid measurements
Shorena Janelidze, Erik Stomrud, Britta Brix, Oskar Hansson
Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set
Christian Puzo, Caroline Labriola, Michael A. Sugarman, Yorghos Tripodis, Brett Martin, Joseph N. Palmisano, Eric G. Steinberg, Thor D. Stein, Neil W. Kowall, Ann C. McKee, Jesse Mez, Ronald J. Killiany, Robert A. Stern, Michael L. Alosco
Tau and atrophy: domain-specific relationships with cognition
Leonardino A. Digma, John R. Madsen, Emilie T. Reas, Anders M. Dale, James B. Brewer, Sarah J. Banks
Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study
Lisa Miebach, Steffen Wolfsgruber, Alexandra Polcher, Oliver Peters, Felix Menne, Katja Luther, Enise Incesoy, Josef Priller, Eike Spruth, Slawek Altenstein, Katharina Buerger, Cihan Catak, Daniel Janowitz, Robert Perneczky, Julia Utecht, Christoph Laske, Martina Buchmann, Anja Schneider, Klaus Fliessbach, Pascal Kalbhen, Michael T. Heneka, Frederic Brosseron, Annika Spottke, Nina Roy, Stefan J. Teipel, Ingo Kilimann, Jens Wiltfang, Claudia Bartels, Emrah Düzel, Laura Dobisch, Coraline Metzger, Dix Meiberth, Alfredo Ramirez, Frank Jessen, Michael Wagner
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
Matthias Brendel, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters, Barbara von Ungern-Sternberg, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Andreas Zwergal, Johannes Levin, Peter Bartenstein, Igor Yakushev, Paul Cumming, Guido Boening, Sibylle Ziegler, Jochen Herms, Armin Giese, Axel Rominger
Further analyses of the safety of verubecestat in the phase 3 EPOCH trial of mild-to-moderate Alzheimer’s disease
Michael F. Egan, Yuki Mukai, Tiffini Voss, James Kost, Julie Stone, Christine Furtek, Erin Mahoney, Jeffrey L. Cummings, Pierre N. Tariot, Paul S. Aisen, Bruno Vellas, Christopher Lines, David Michelson
Music and emotion in Alzheimer’s disease
Eva M. Arroyo-Anlló, Stéphanie Dauphin, M. Noelle Fargeau, Pierre Ingrand, Roger Gil
Depression, subjective cognitive decline, and the risk of neurocognitive disorders
Tau Ming Liew
A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain
Jorge L. Del-Aguila, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Maria Victoria Fernandez, Laura Ibanez, Joseph Bradley, Fengxian Wang, Kristy Bergmann, Richard Davenport, John C. Morris, David M. Holtzman, Richard J. Perrin, Bruno A. Benitez, Joseph Dougherty, Carlos Cruchaga, Oscar Harari
Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI
Paula M. Petrone, Adrià Casamitjana, Carles Falcon, Miquel Artigues, Grégory Operto, Raffaele Cacciaglia, José Luis Molinuevo, Verónica Vilaplana, Juan Domingo Gispert
Souvenaid in the management of mild cognitive impairment: an expert consensus opinion
Jeffrey Cummings, Peter Passmore, Bernadette McGuinness, Vincent Mok, Christopher Chen, Sebastiaan Engelborghs, Michael Woodward, Sagrario Manzano, Guillermo Garcia-Ribas, Stefano Cappa, Paulo Bertolucci, Leung-Wing Chu
Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey
Daniela Bertens, Stephanie Vos, Patrick Kehoe, Henrike Wolf, Flavio Nobili, Alexandre Mendonça, Ineke van Rossum, Jacub Hort, Jose Luis Molinuevo, Michael Heneka, Ron Petersen, Philip Scheltens, Pieter Jelle Visser
Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer’s disease: a preclinical study in rTg4510 mice
Joshua B. Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Candice C. Askwith, Lin Lin, Michael W. Shultis, Kevin J. Hodgetts, Chien-Liang Glenn Lin
The “rights” of precision drug development for Alzheimer’s disease
Jeffrey Cummings, Howard H. Feldman, Philip Scheltens
ABIDE Delphi study: topics to discuss in diagnostic consultations in memory clinics
Agnetha D. Fruijtier, Leonie N. C. Visser, Ingrid S. van Maurik, Marissa D. Zwan, Femke H. Bouwman, Wiesje M. van der Flier, Ellen M. A. Smets
Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
Arno de Wilde, Juhan Reimand, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Femke Bouwman, Rik Ossenkoppele
Sleep experiences during different lifetime periods and in vivo Alzheimer pathologies
Young Min Choe, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Bo Kyung Sohn, Yu Kyeong Kim, Seong A Shin, Chul-Ho Sohn, Yu Jin Lee, Dong Young Lee
Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas
Lindsey Isla Sinclair, Amit Kumar, Taher Darreh-Shori, Seth Love
CSF evidence of pericyte damage in Alzheimer’s disease is associated with markers of blood-brain barrier dysfunction and disease pathology
J. S. Miners, P. G. Kehoe, S. Love, H. Zetterberg, K. Blennow
Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer’s and Parkinson’s disease
Simon Sjödin, Gunnar Brinkmalm, Annika Öhrfelt, Lucilla Parnetti, Silvia Paciotti, Oskar Hansson, John Hardy, Kaj Blennow, Henrik Zetterberg, Ann Brinkmalm
Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies
Inger van Steenoven, Wiesje M. van der Flier, Philip Scheltens, Charlotte E. Teunissen, Afina W. Lemstra
Testing the 2018 NIA-AA research framework in a retrospective large cohort of patients with cognitive impairment: from biological biomarkers to clinical syndromes
Tiziana Carandini, Andrea Arighi, Luca Sacchi, Giorgio G. Fumagalli, Anna M. Pietroboni, Laura Ghezzi, Annalisa Colombi, Marta Scarioni, Chiara Fenoglio, Milena A. De Riz, Giorgio Marotta, Elio Scarpini, Daniela Galimberti
Participant and study partner prediction and identification of cognitive impairment in preclinical Alzheimer’s disease: study partner vs. participant accuracy
Mary M. Ryan, Joshua D. Grill, Daniel L. Gillen
Amyloid β-protein oligomers promote the uptake of tau fibril seeds potentiating intracellular tau aggregation
Woo Shik Shin, Jing Di, Qin Cao, Binsen Li, Paul M. Seidler, Kevin A. Murray, Gal Bitan, Lin Jiang
Midlife physical activity is associated with lower incidence of vascular dementia but not Alzheimer’s disease
Oskar Hansson, Martina Svensson, Anna-Märta Gustavsson, Emelie Andersson, Yiyi Yang, Katarina Nägga, Ulf Hållmarker, Stefan James, Tomas Deierborg
Age-dependent emergence of neurophysiological and behavioral abnormalities in progranulin-deficient mice
Dávid Nagy, Lauren Herl Martens, Liza Leventhal, Angela Chen, Craig Kelley, Milan Stoiljkovic, Mihály Hajós
Association between increased levels of amyloid-β oligomers in plasma and episodic memory loss in Alzheimer’s disease
Xue Meng, Tao Li, Xiao Wang, Xiaozhen Lv, Zhiyu Sun, Jichun Zhang, Feng Su, Sungmin Kang, SangYun Kim, Seong Soo A. An, Xin Yu, Chen Zhang, Huali Wang
Retinal thinning of inner sub-layers is associated with cortical atrophy in a mouse model of Alzheimer’s disease: a longitudinal multimodal in vivo study
Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco, António Francisco Ambrósio
Clinical validation of the Lumipulse G cerebrospinal fluid assays for routine diagnosis of Alzheimer’s disease
Maria João Leitão, Anuschka Silva-Spínola, Isabel Santana, Veronica Olmedo, Alicia Nadal, Nathalie Le Bastard, Inês Baldeiras
Study partner types and prediction of cognitive performance: implications to preclinical Alzheimer’s trials
Michelle M. Nuño, Daniel L. Gillen, Joshua D. Grill
Systemic and central nervous system metabolic alterations in Alzheimer’s disease
Vera van der Velpen, Tony Teav, Héctor Gallart-Ayala, Florence Mehl, Ioana Konz, Christopher Clark, Aikaterini Oikonomidi, Gwendoline Peyratout, Hugues Henry, Mauro Delorenzi, Julijana Ivanisevic, Julius Popp
Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers
Nicholas J. Ashton, Marc Suárez-Calvet, Amanda Heslegrave, Abdul Hye, Cristina Razquin, Pau Pastor, Raquel Sanchez-Valle, José L. Molinuevo, Pieter Jelle Visser, Kaj Blennow, Angela K. Hodges, Henrik Zetterberg
Transcranial magnetic stimulation and amyloid markers in mild cognitive impairment: impact on diagnostic confidence and diagnostic accuracy
Alessandro Padovani, Alberto Benussi, Maria Sofia Cotelli, Clarissa Ferrari, Valentina Cantoni, Valentina Dell’Era, Rosanna Turrone, Barbara Paghera, Barbara Borroni
Plasma Aβ42/40 ratio alone or combined with FDG-PET can accurately predict amyloid-PET positivity: a cross-sectional analysis from the AB255 Study
Virginia Pérez-Grijalba, Javier Arbizu, Judith Romero, Elena Prieto, Pedro Pesini, Leticia Sarasa, Fernando Guillen, Inmaculada Monleón, Itziar San-José, Pablo Martínez-Lage, Josep Munuera, Isabel Hernández, Mar Buendía, Oscar Sotolongo-Grau, Montserrat Alegret, Agustín Ruiz, Lluis Tárraga, Mercè Boada, Manuel Sarasa, Miguel Goñi, Francesc Pujadas, Alberto Villarejo, Ana Frank, Jordi Peña-Casanova, Manuel Fernández, Gerard Piñol, Rafael Blesa, Pedro Gil, Luis F. Pascual, Miquel Aguilar, Giovanni B. Frisoni, Jorge Matias-Guiu, Niels Andreasen, Carmen Antúnez
Characterization of the selective in vitro and in vivo binding properties of crenezumab to oligomeric Aβ
William J. Meilandt, Janice A. Maloney, Jose Imperio, Guita Lalehzadeh, Tim Earr, Susan Crowell, Travis W. Bainbridge, Yanmei Lu, James A. Ernst, Reina N. Fuji, Jasvinder K. Atwal
Effects of functional tasks exercise on cognitive functions of older adults with mild cognitive impairment: a randomized controlled pilot trial
Lawla L. F. Law, Vincent C. T. Mok, Matthew M. K. Yau
Progression to dementia in memory clinic patients with mild cognitive impairment and normal β-amyloid
Anna Rosenberg, Alina Solomon, Vesna Jelic, Göran Hagman, Nenad Bogdanovic, Miia Kivipelto
PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases
Juhan Reimand, Arno de Wilde, Charlotte E. Teunissen, Marissa Zwan, Albert D. Windhorst, Ronald Boellaard, Frederik Barkhof, Wiesje M. van der Flier, Philip Scheltens, Bart N. M. van Berckel, Rik Ossenkoppele, Femke Bouwman
Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer’s disease: a PET substudy interim analysis
Gregory Klein, Paul Delmar, Nicola Voyle, Sunita Rehal, Carsten Hofmann, Danielle Abi-Saab, Mirjana Andjelkovic, Smiljana Ristic, Guoqiao Wang, Randall Bateman, Geoffrey A. Kerchner, Monika Baudler, Paulo Fontoura, Rachelle Doody
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer’s disease
Lindsay Poppe, Laura Rué, Mieke Timmers, Annette Lenaerts, Annet Storm, Zsuzsanna Callaerts-Vegh, Gilles Courtand, Antina de Boer, Silke Smolders, Philip Van Damme, Ludo Van Den Bosch, Rudi D’Hooge, Bart De Strooper, Wim Robberecht, Robin Lemmens
ABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease
Ya-Ting Chang, Shih-Wei Hsu, Shu-Hua Huang, Chi-Wei Huang, Wen-Neng Chang, Chia-Yi Lien, Jun-Jun Lee, Chen-Chang Lee, Chiung-Chih Chang
HHV-6A infection induces amyloid-beta expression and activation of microglial cells
Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizzo
Rescue of cognitive deficits in APP/PS1 mice by accelerating the aggregation of β-amyloid peptide
Jian-Xiang Zhang, Yi-Hui Lai, Pan-Ying Mi, Xue-Ling Dai, Ran Zhang, Zhan-Jun Zhang, Shu-Juan Zhang, Xi-Wen Zhang, Xi-Yan Zhang, Bing-Yu Yang, Dong-Mei Cui, Chen Zhang, Chang-Qi Zhao, Fei Dou
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
Hayk Davtyan, Armine Hovakimyan, Sepideh Kiani Shabestari, Tatevik Antonyan, Morgan A. Coburn, Karen Zagorski, Gor Chailyan, Irina Petrushina, Olga Svystun, Emma Danhash, Nikolai Petrovsky, David H. Cribbs, Michael G. Agadjanyan, Mathew Blurton-Jones, Anahit Ghochikyan
Pay attention to the basal ganglia: a volumetric study in early dementia with Lewy bodies
Anne Botzung, Nathalie Philippi, Vincent Noblet, Paulo Loureiro de Sousa, Frédéric Blanc
Cognitively normal women with Alzheimer’s disease proteinopathy show relative preservation of memory but not of hippocampal volume
Jessica Z. K. Caldwell, Jeffrey L. Cummings, Sarah J. Banks, Sebastian Palmqvist, Oskar Hansson
Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model
Jaewoo Shin, Chanho Kong, Jihyeon Lee, Bo Young Choi, Jiyeon Sim, Chin Su Koh, Minkyung Park, Young Cheol Na, Sang Won Suh, Won Seok Chang, Jin Woo Chang
Plasma amyloid assay as a pre-screening tool for amyloid positron emission tomography imaging in early stage Alzheimer’s disease
Szu-Ying Lin, Kun-Ju Lin, Po-Chen Lin, Chin-Chang Huang, Chiung-Chih Chang, Yi-Chung Lee, Ing-Tsung Hsiao, Tzu-Chen Yen, Wen-Sheng Huang, Bang-Hung Yang, Pei-Ning Wang
High occurrence of transportation and logistics occupations among vascular dementia patients: an observational study
A. C. van Loenhoud, C. de Boer, K. Wols, Y. A. Pijnenburg, A. W. Lemstra, F. H. Bouwman, N. D. Prins, P. Scheltens, R. Ossenkoppele, W. M. van der Flier
APOE2 orchestrated differences in transcriptomic and lipidomic profiles of postmortem AD brain
Iliya Lefterov, Cody M. Wolfe, Nicholas F. Fitz, Kyong Nyon Nam, Florent Letronne, Richard J. Biedrzycki, Julia Kofler, Xianlin Han, Jianing Wang, Jonathan Schug, Radosveta Koldamova