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BMC Cancer

Ausgabe 1/2011

Inhalt (529 Artikel)

Open Access Research article

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

Caterina Peraldo-Neia, Giorgia Migliardi, Maurizia Mello-Grand, Filippo Montemurro, Raffaella Segir, Ymera Pignochino, Giuliana Cavalloni, Bruno Torchio, Luciano Mosso, Giovanna Chiorino, Massimo Aglietta

Open Access Research article

Effects of EpCAM overexpression on human breast cancer cell lines

Johanna M Gostner, Dominic Fong, Oliver A Wrulich, Florian Lehne, Marion Zitt, Martin Hermann, Sylvia Krobitsch, Agnieszka Martowicz, Guenther Gastl, Gilbert Spizzo

Open Access Research article

A functional and transcriptomic analysis of NET1 bioactivity in gastric cancer

Gayle Bennett, Denise Sadlier, Peter P Doran, Padraic MacMathuna, David W Murray

Open Access Research article

Synergistic antitumor effect of AAV-mediated TRAIL expression combined with cisplatin on head and neck squamous cell carcinoma

Minghong Jiang, Zheng Liu, Yang Xiang, Hong Ma, Shilian Liu, Yanxin Liu, Dexian Zheng

Open Access Research article

Establishing a relationship between prolactin and altered fatty acid β-Oxidation via carnitine palmitoyl transferase 1 in breast cancer cells

Katja Linher-Melville, Stephanie Zantinge, Toran Sanli, Hertzel Gerstein, Theodoros Tsakiridis, Gurmit Singh

Open Access Research article

MicroRNA-203 inhibits cell proliferation by repressing ΔNp63 expression in human esophageal squamous cell carcinoma

Yang Yuan, Zhi-Yong Zeng, Xiao-Hong Liu, De-Jun Gong, Jing Tao, He-Zhong Cheng, Sheng-Dong Huang

Open Access Research article

SFRP1 reduction results in an increased sensitivity to TGF-β signaling

Kelly J Gauger, Kerry L Chenausky, Molly E Murray, Sallie S Schneider

Open Access Research article

In vivo Identification and Specificity assessment of mRNA markers of hypoxia in human and mouse tumors

Morten Busk, Kasper Toustrup, Brita S Sørensen, Jan Alsner, Michael R Horsman, Steen Jakobsen, Jens Overgaard

Open Access Research article

Circulating lymphocyte is an important determinant of the effectiveness of preoperative radiotherapy in advanced rectal cancer

Joji Kitayama, Koji Yasuda, Kazushige Kawai, Eiji Sunami, Hirokazu Nagawa

Open Access Research article

Viral-mediated oncolysis is the most critical factor in the late-phase of the tumor regression process upon vaccinia virus infection

Stephanie Weibel, Viktoria Raab, Yong A Yu, Andrea Worschech, Ena Wang, Francesco M Marincola, Aladar A Szalay

Open Access Study protocol

Combined treatment of adenoid cystic carcinoma with cetuximab and IMRT plus C12 heavy ion boost: ACCEPT [ACC, Erbitux®and particle therapy]

Alexandra D Jensen, Anna Nikoghosyan, Axel Hinke, Jürgen Debus, Marc W Münter

Open Access Research article

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

Caroline MM van Geelen, Bodvael Pennarun, Phuong TK Le, Elisabeth GE de Vries, Steven de Jong

Open Access Study protocol

Phase II study evaluating consolidation whole abdominal intensity-modulated radiotherapy (IMRT) in patients with advanced ovarian cancer stage FIGO III - The OVAR-IMRT-02 Study

Nathalie Rochet, Meinhard Kieser, Florian Sterzing, Sonja Krause, Katja Lindel, Wolfgang Harms, Michael H Eichbaum, Andreas Schneeweiss, Christof Sohn, Juergen Debus

Open Access Research article

Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinoma

Gregory Sergeant, Tania Roskams, Jos van Pelt, François Houtmeyers, Raymond Aerts, Baki Topal

Open Access Study protocol

A randomised trial of a psychosocial intervention for cancer patients integrated into routine care: the PROMPT study (promoting optimal outcomes in mood through tailored psychosocial therapies)

Jane Turner, Brian Kelly, David Clarke, Patsy Yates, Sanchia Aranda, Damien Jolley, Suzanne Chambers, Maryanne Hargraves, Lisa McFadyen

Open Access Research article

Concurrent cisplatin, continuous infusion fluorouracil and radiotherapy followed by tailored consolidation treatment in non metastatic anal squamous cell carcinoma

Maria G Zampino, Elena Magni, Maria C Leonardi, Luigi Santoro, Elena Petazzi, Cristiana Fodor, Giuseppe Petralia, Cristina Trovato, Franco Nolè, Roberto Orecchia

Open Access Research article

Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells

Chien-Chih Lee, Yi-Hsiung Lin, Wen-Hsin Chang, Pei-Chin Lin, Yang-Chang Wu, Jan-Gowth Chang

Open Access Research article

Mutational profiling reveals PIK3CA mutations in gallbladder carcinoma

Vikram Deshpande, Afamefuna Nduaguba, Stephanie M Zimmerman, Sarah M Kehoe, Laura E MacConaill, Gregory Y Lauwers, Cristina Ferrone, Nabeel Bardeesy, Andrew X Zhu, Aram F Hezel

Open Access Research article

Multimodal microscopy for automated histologic analysis of prostate cancer

Jin Tae Kwak, Stephen M Hewitt, Saurabh Sinha, Rohit Bhargava

Open Access Research article

The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

Jette Bornholdt, Stine Friis, Sine Godiksen, Steen S Poulsen, Eric Santoni-Rugiu, Hanne C Bisgaard, Inger MB Lothe, Tone Ikdahl, Kjell M Tveit, Egil Johnson, Elin H Kure, Lotte K Vogel

Open Access Research article

Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

Helena Carén, Anna Djos, Maria Nethander, Rose-Marie Sjöberg, Per Kogner, Camilla Enström, Staffan Nilsson, Tommy Martinsson

Open Access Study protocol

Phase i study evaluating the treatment of patients with hepatocellular carcinoma (HCC) with carbon ion radiotherapy: The PROMETHEUS-01 trial

Stephanie E Combs, Daniel Habermehl, Tom Ganten, Jan Schmidt, Lutz Edler, Iris Burkholder, Oliver Jäkel, Thomas Haberer, Jürgen Debus

Open Access Research article

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

Alejandra Ward, Alan Morettin, David Shum, John W Hudson

Open Access Research article

Transcription factors zeb1, twist and snai1 in breast carcinoma

Ylermi Soini, Hanna Tuhkanen, Reijo Sironen, Ismo Virtanen, Vesa Kataja, Päivi Auvinen, Arto Mannermaa, Veli-Matti Kosma

Open Access Case report

Leiomyosarcoma with partial rhabdomyoblastic differentiation: First case report of primary cardiac origin

Yoichiro Okubo, Kazutoshi Shibuya, Atsushi Namiki, Kazuhisa Takamura, Noriaki Kameda, Tetsuo Nemoto, Aki Mitsuda, Megumi Wakayama, Minoru Shinozaki, Nobuyuki Hiruta, Kanako Kitahara, Takao Ishiwatari, Junichi Yamazaki

Open Access Research article

A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

Jane M Valentine, Sonia Kumar, Abdeladim Moumen

Open Access Research article

FGFR4 Gly388Arg polymorphism contributes to prostate cancer development and progression: A meta-analysis of 2618 cases and 2305 controls

Bin Xu, Na Tong, Shu Q Chen, Li X Hua, Zeng J Wang, Zheng D Zhang, Ming Chen

Open Access Research article

Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts

Wenxia Meng, Qingjie Xia, Lanyan Wu, Sixiu Chen, Xin He, Lin Zhang, Qinghong Gao, Hongmei Zhou

Open Access Research article

Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases

Zhihong Chi, Siming Li, Xinan Sheng, Lu Si, Chuanliang Cui, Mei Han, Jun Guo

Open Access Research article

Exploring the uncertainties of early detection results: model-based interpretation of mayo lung project

Lu Shi, Haijun Tian, William J McCarthy, Barbara Berman, Shinyi Wu, Rob Boer

Open Access Research article

Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

Genni M Newnham, Matthew Conron, SueAnne McLachlan, Alexander Dobrovic, Hongdo Do, Jason Li, Kenneth Opeskin, Natalie Thompson, Gavin M Wright, David M Thomas

Open Access Research article

The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development

Kamel Rouissi, Islem Ben Bahria, Karim Bougatef, Raja Marrakchi, Nejla Stambouli, Khouloud Hamdi, Mohamed Cherif, Mohamed Riadh Ben Slama, Mohamed Sfaxi, Fethi Ben Othman, Mohamed Chebil, Amel Benammar Elgaaied, Slah Ouerhani

Open Access Research article

A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population

Keke Zhou, Dezhi Hu, Juan Lu, Weiwei Fan, Hongliang Liu, Hongyan Chen, Gong Chen, Qingyi Wei, Guhong Du, Ying Mao, Daru Lu, Liangfu Zhou

Open Access Research article

Prognostic impact of CD168 expression in gastric cancer

Sumiya Ishigami, Shinichi Ueno, Yuka Nishizono, Masataka Matsumoto, Hiroshi Kurahara, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Kita Yoshiaki, Yuko Kijima, Masaki Kitazono, Shoji Natsugoe

Open Access Research article

EGFR related mutational status and association to clinical outcome of third-line cetuximab-irinotecan in metastatic colorectal cancer

Karen-Lise G Spindler, Niels Pallisgaard, Jan Lindebjerg, Sanne K Frifeldt, Anders Jakobsen

Open Access Research article

Interaction and uptake of exosomes by ovarian cancer cells

Cristina Escrevente, Sascha Keller, Peter Altevogt, Júlia Costa

Open Access Research article

Replicase-based plasmid DNA shows anti-tumor activity

B Leticia Rodriguez, Zhen Yu, Woon-Gye Chung, Richard Weiss, Zhengrong Cui

Open Access Research article

The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines

Stacey L Fossey, Misty D Bear, Jiayuh Lin, Chenglong Li, Eric B Schwartz, Pui-Kai Li, James R Fuchs, Joelle Fenger, William C Kisseberth, Cheryl A London

Open Access Research article

The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro

Philipp Lechler, Tobias Renkawitz, Valentina Campean, Sanjeevi Balakrishnan, Markus Tingart, Joachim Grifka, Jens Schaumburger

Open Access Research article

Safety and treatment patterns of multikinase inhibitors in patients with metastatic renal cell carcinoma at a tertiary oncology center in Italy

Camillo Porta, Chiara Paglino, Ilaria Imarisio, Cinzia Canipari, Kristina Chen, Maureen Neary, Mei Sheng Duh

Open Access Research article

P27Kip1, regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells

Min Wei, Zhiwei Wang, Hongliang Yao, Zhongyin Yang, Qing Zhang, Bingya Liu, Yingyan Yu, Liping Su, Zhenggang Zhu, Qinlong Gu

Open Access Case report

Seminal vesicle metastasis after partial hepatectomy for hepatocellular carcinoma

Li Gong, Minwen Zheng, Yanhong Li, Wendong Zhang, Wangjun Bu, Lifang Shi, Wei Zhang, Hong Yan

Open Access Research article

Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells

Guo-fang Zeng, Shao-xi Cai, Guang-Jer Wu

Open Access Research article

Prediction of outcome after diagnosis of metachronous contralateral breast cancer

Sara Alkner, Pär-Ola Bendahl, Mårten Fernö, Jonas Manjer, Lisa Rydén

Open Access Research article

Adjuvant therapy for locally advanced renal cell cancer: A systematic review with meta-analysis

Adolfo JO Scherr, Joao Paulo SN Lima, Emma C Sasse, Carmen SP Lima, André D Sasse

Open Access Research article

Small lytic peptides escape the inhibitory effect of heparan sulfate on the surface of cancer cells

Bodil Fadnes, Lars Uhlin-Hansen, Inger Lindin, Øystein Rekdal

Open Access Research article

Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma

Chau-Ting Yeh, Hui-Chin Chen, Chang-Mu Sung, Cheng-Lung Hsu, Chen-Chun Lin, Kuang-Tse Pan, Jeng-Hwei Tseng, Chien-Fu Hung

Open Access Research article

Significant survival improvement of patients with recurrent breast cancer in the periods 2001-2008 vs. 1992-2000

Hideo Shigematsu, Hidetoshi Kawaguchi, Yoshiaki Nakamura, Kimihiro Tanaka, Satoko Shiotani, Chinami Koga, Sumiko Nishimura, Kenichi Taguchi, Kenichi Nishiyama, Shinji Ohno

Open Access Research article

A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival

Jyotsna Batra, Christina M Nagle, Tracy O'Mara, Melanie Higgins, Ying Dong, Olivia L Tan, Felicity Lose, Lene Marie Skeie, Srilakshmi Srinivasan, Kelly L Bolton, Honglin Song, Susan J Ramus, Simon A Gayther, Paul DP Pharoah, Mary-Anne Kedda, Amanda B Spurdle, Judith A Clements

Open Access Research article

Latexin expression is downregulated in human gastric carcinomas and exhibits tumor suppressor potential

Yong Li, Zhuoma Basang, Huirong Ding, Zheming Lu, Tao Ning, Haoran Wei, Hong Cai, Yang Ke

Open Access Research article

Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer

Akira Ooki, Keishi Yamashita, Shiro Kikuchi, Shinichi Sakuramoto, Natsuya Katada, Mina Waraya, Hiroshi Kawamata, Hiroshi Nishimiya, Kazunori Nakamura, Masahiko Watanabe

Open Access Research article

Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors

Adam Naguib, James C Cooke, Lisa Happerfield, Lucy Kerr, Laura J Gay, Robert N Luben, Richard Y Ball, Panagiota N Mitrou, Alison McTaggart, Mark J Arends

Open Access Research article

Vascular normalization in orthotopic glioblastoma following intravenous treatment with lipid-based nanoparticulate formulations of irinotecan (Irinophore C™), doxorubicin (Caelyx®) or vincristine

Maite Verreault, Dita Strutt, Dana Masin, Malathi Anantha, Andrew Yung, Piotr Kozlowski, Dawn Waterhouse, Marcel B Bally, Donald T Yapp

Open Access Research article

Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines

Stacey L Fossey, Misty D Bear, William C Kisseberth, Michael Pennell, Cheryl A London

Open Access Research article

Acceptance of oral chemotherapy in breast cancer patients - a survey study

Sarah Schott, Andreas Schneeweiss, Judith Reinhardt, Thomas Bruckner, Christoph Domschke, Christof Sohn, Michael H Eichbaum

Open Access Review

Renal cell cancer among African Americans: an epidemiologic review

Loren Lipworth, Robert E Tarone, Joseph K McLaughlin

Open Access Research article

Health-related Quality of life in 640 head and neck cancer survivors after radiotherapy using EORTC QLQ-C30 and QLQ-H&N35 questionnaires

Stephen Wan Leung, Tsair-Fwu Lee, Chih-Yen Chien, Pei-Ju Chao, Wen-Ling Tsai, Fu-Min Fang

Open Access Research article

Evaluating the impact of Relative Total Dose Intensity (RTDI) on patients' short and long-term outcome in taxane- and anthracycline-based chemotherapy of metastatic breast cancer- a pooled analysis

Sibylle Loibl, Tomas Skacel, Valentina Nekljudova, Hans Joachim Lück, Matthias Schwenkglenks, Thomas Brodowicz, Christoph Zielinski, Gunter von Minckwitz

Open Access Research article

Does comorbidity explain the ethnic inequalities in cervical cancer survival in New Zealand? A retrospective cohort study

Naomi Brewer, Barry Borman, Diana Sarfati, Mona Jeffreys, Steven T Fleming, Soo Cheng, Neil Pearce

Open Access Study protocol

Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: Phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6 × FEC versus 3 × FEC/3 × Docetaxel

Eva J Kantelhardt, Martina Vetter, Marcus Schmidt, Corinne Veyret, Doris Augustin, Volker Hanf, Christoph Meisner, Daniela Paepke, Manfred Schmitt, Fred Sweep, Gunter von Minckwitz, Pierre-Marie Martin, Fritz Jaenicke, Christoph Thomssen, Nadia Harbeck

Open Access Research article

Detection of erbB2 copy number variations in plasma of patients with esophageal carcinoma

Immacolata Andolfo, Giuseppe Petrosino, Loredana Vecchione, Pasqualino De Antonellis, Mario Capasso, Donatella Montanaro, Marica Gemei, Giancarlo Troncone, Achille Iolascon, Michele Orditura, Fortunato Ciardiello, Fernando De Vita, Massimo Zollo

Open Access Research article

Does age matter? - A MRI study on peritumoral edema in newly diagnosed primary glioblastoma

Clemens Seidel, Nils Dörner, Matthias Osswald, Antje Wick, Michael Platten, Martin Bendszus, Wolfgang Wick

Open Access Research article

Inhibition of nuclear factor kappa-B signaling reduces growth in medulloblastoma in vivo

Susan E Spiller, Naomi J Logsdon, Lindsey A Deckard, Harald Sontheimer

Open Access Research article

Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo

Seung Joon Lee, Candice Krauthauser, Victoria Maduskuie, Paul T Fawcett, James M Olson, Sigrid A Rajasekaran

Open Access Research article

Cigarette, cigar and pipe smoking, passive smoke exposure, and risk of pancreatic cancer: a population-based study in the San Francisco Bay Area

Gregory J Tranah, Elizabeth A Holly, Furong Wang, Paige M Bracci

Open Access Research article

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

Kuo-Jang Kao, Kai-Ming Chang, Hui-Chi Hsu, Andrew T Huang

Open Access Research article

Inflammatory mediators in breast cancer: Coordinated expression of TNFα & IL-1β with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition

Gali Soria, Maya Ofri-Shahak, Ilana Haas, Neora Yaal-Hahoshen, Leonor Leider-Trejo, Tal Leibovich-Rivkin, Polina Weitzenfeld, Tsipi Meshel, Esther Shabtai, Mordechai Gutman, Adit Ben-Baruch

Open Access Research article

Keratin 23, a novel DPC4/Smad4 target gene which binds 14-3-3ε

Sven-T Liffers, Abdelouahid Maghnouj, Johanna B Munding, René Jackstadt, Ulrike Herbrand, Thomas Schulenborg, Katrin Marcus, Susanne Klein-Scory, Wolff Schmiegel, Irmgard Schwarte-Waldhoff, Helmut E Meyer, Kai Stühler, Stephan A Hahn

Open Access Research article

Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells

Sheng-Chun Chiu, Mei-Jen Wang, Hsueh-Hui Yang, Shee-Ping Chen, Sung-Ying Huang, Yi-Lin Chen, Shinn-Zong Lin, Horng-Jyh Harn, Cheng-Yoong Pang

Open Access Research article

Increase in intracellular PGE2 induces apoptosis in Bax-expressing colon cancer cell

Lisenn Lalier, François Pedelaborde, Christophe Braud, Jean Menanteau, François M Vallette, Christophe Olivier

Open Access Research article

Highly frequent promoter methylation and PIK3CA amplification in non-small cell lung cancer (NSCLC)

Meiju Ji, Haixia Guan, Cuixia Gao, Bingyin Shi, Peng Hou

Open Access Research article

Sentinel lymph node biopsy as guidance for radical trachelectomy in young patients with early stage cervical cancer

Xue-lian Du, Xiu-gui Sheng, Tao Jiang, Qing-shui Li, Hao Yu, Chun-xia Pan, Chun-hua Lu, Cong Wang, Qu-qing Song

Open Access Research article

Loss of aquaporin-4 expression and putative function in non-small cell lung cancer

Arne Warth, Thomas Muley, Michael Meister, Esther Herpel, Anita Pathil, Hans Hoffmann, Philipp A Schnabel, Christian Bender, Andreas Buness, Peter Schirmacher, Ruprecht Kuner

Open Access Study protocol

Randomized controlled phase I/II study to investigate immune stimulatory effects by low dose radiotherapy in primarily operable pancreatic cancer

Carmen Timke, Hubertus Schmitz Winnenthal, Felix Klug, Falk FF Roeder, Andreas Bonertz, Christoph Reissfelder, Nathalie Rochet, Moritz Koch, Christine Tjaden, Markus W Buechler, Juergen Debus, Jens Werner, Philipp Beckhove, Jürgen Weitz, Peter E Huber

Open Access Research article

Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer

Chen-Yun Yeh, Shin-Mei Shin, Hsuan-Heng Yeh, Tsung-Jung Wu, Jyh-Wei Shin, Tsuey-Yu Chang, Giri Raghavaraju, Chung-Ta Lee, Jung-Hsien Chiang, Vincent S Tseng, Yuan-Chii G Lee, Cheng-Huang Shen, Nan-Haw Chow, Hsiao-Sheng Liu

Open Access Research article

Diagnosis delay of breast cancer and its associated factors in Malaysian women

Bachok Norsa'adah, Krishna G Rampal, Mohd A Rahmah, Nyi N Naing, Biswa M Biswal

Open Access Research article

Increased expression of transcription factor TFAP2α correlates with chemosensitivity in advanced bladder cancer

Iver Nordentoft, Lars Dyrskjøt, Julie S Bødker, Peter J Wild, Arndt Hartmann, Simone Bertz, Jan Lehmann, Torben F Ørntoft, Karin Birkenkamp-Demtroder

Open Access Research article

Income level and regional policies, underlying factors associated with unwarranted variations in conservative breast cancer surgery in Spain

Manuel Ridao-López, Sandra García-Armesto, Begoña Abadía-Taira, Salvador Peiró-Moreno, Enrique Bernal-Delgado

Open Access Research article

The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism

Fernando J Reyes-Zurita, Gisela Pachón-Peña, Daneida Lizárraga, Eva E Rufino-Palomares, Marta Cascante, José A Lupiáñez

Open Access Research article

WEE1 inhibition sensitizes osteosarcoma to radiotherapy

Jantine PosthumaDeBoer, Thomas Würdinger, Harm CA Graat, Victor W van Beusechem, Marco N Helder, Barend J van Royen, Gertjan JL Kaspers

Open Access Research article

Influence of family size and birth order on risk of cancer: a population-based study

Melanie Bevier, Marianne Weires, Hauke Thomsen, Jan Sundquist, Kari Hemminki

Open Access Study protocol

Whole brain radiotherapy after local treatment of brain metastases in melanoma patients - a randomised phase III trial

Gerald Fogarty, Rachael L Morton, Janette Vardy, Anna K Nowak, Catherine Mandel, Peta M Forder, Angela Hong, George Hruby, Bryan Burmeister, Brindha Shivalingam, Haryana Dhillon, John F Thompson

Open Access Debate

Applying strategies from libertarian paternalism to decision making for prostate specific antigen (PSA) screening

David C Wheeler, Konrad M Szymanski, Amanda Black, David E Nelson

Open Access Research article

Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice

Chun-Li Xiao, Zhong-Hua Tao, Lin Guo, Wei-Wei Li, Jin-Liang Wan, Hui-Chuan Sun, Lu Wang, Zhao-You Tang, Jia Fan, Wei-Zhong Wu

Open Access Research article

CD248 facilitates tumor growth via its cytoplasmic domain

Margarida Maia, Astrid DeVriese, Tom Janssens, Michaël Moons, Rik J Lories, Jan Tavernier, Edward M Conway

Open Access Research article

A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone

Jeffrey D Altenburg, Andrew A Bieberich, Colin Terry, Kevin A Harvey, Justin F VanHorn, Zhidong Xu, V Jo Davisson, Rafat A Siddiqui

Open Access Research article

Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan

Mei-Due Yang, Hwei-Chung Wang, Wen-Shin Chang, Chia-Wen Tsai, Da-Tian Bau

Open Access Research article

Admission of advanced lung cancer patients to intensive care unit: A retrospective study of 76 patients

Claire Andréjak, Nicolas Terzi, Stéphanie Thielen, Emmanuel Bergot, Gérard Zalcman, Pierre Charbonneau, Vincent Jounieaux

Open Access Research article

Socioeconomic status and the incidence of non-central nervous system childhood embryonic tumours in Brazil

Beatriz de Camargo, Juliana Moreira de Oliveira Ferreira, Rejane de Souza Reis, Sima Ferman, Marceli de Oliveira Santos, Maria S Pombo-de-Oliveira

Open Access Research article

The prognostic effect of ethnicity for gastric and esophageal cancer: the population-based experience in British Columbia, Canada

Morteza Bashash, T Greg Hislop, Amil M Shah, Nhu Le, Angela Brooks-Wilson, Chris D Bajdik

Open Access Research article

Adenoviral infectivity of exfoliated viable cells in urine: Implications for the detection of bladder cancer

Anuradha Murali, Laura Kasman, Christina Voelkel-Johnson

Open Access Research article

Genes Associated With Prognosis After Surgery For Malignant Pleural Mesothelioma Promote Tumor Cell Survival In Vitro

Gavin J Gordon, Raphael Bueno, David J Sugarbaker

Open Access Research article

Celastrol targets mitochondrial respiratory chain complex I to induce reactive oxygen species-dependent cytotoxicity in tumor cells

Guozhu Chen, Xuhui Zhang, Ming Zhao, Yan Wang, Xiang Cheng, Di Wang, Yuanji Xu, Zhiyan Du, Xiaodan Yu

Open Access Research article

G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells

Chang-Chieh Wu, Fu-Ming Tsai, Rong-Yaun Shyu, Ya-Ming Tsai, Chun-Hua Wang, Shun-Yuan Jiang

Open Access Research article

HGF/c-met/Stat3 signaling during skin tumor cell invasion: indications for a positive feedback loop

Zanobia A Syed, Weihong Yin, Kendall Hughes, Jennifer N Gill, Runhua Shi, John L Clifford

Open Access Study protocol

Treatment of malignant sinonasal tumours with intensity-modulated radiotherapy (IMRT) and carbon ion boost (C12)

Alexandra D Jensen, Anna V Nikoghosyan, Christine Windemuth-Kieselbach, Jürgen Debus, Marc W Münter

Open Access Erratum

Erratum to: Association of the germline TP53 R337H mutation with breast cancer in southern Brazil

Juliana G Assumpção, Ana Luíza Seidinger, Maria José Mastellato, Raul C Ribeiro, Gerard P Zambetti, Ramapriya Ganti, Kumar Srivastava, Sheila Shurtleff, Deqing Pei, Luiz Carlos Zeferino, Rozany M Dufloth, Silvia Regina Brandalise, José Andres Yunes

Open Access Research article

Growth of breast cancer recurrences assessed by consecutive MRI

Ingrid Millet, Emmanuelle Bouic-Pages, Denis Hoa, David Azria, Patrice Taourel

Open Access Research article

Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism

Melanie J Voss, Mischa F Möller, Desmond G Powe, Bernd Niggemann, Kurt S Zänker, Frank Entschladen

Open Access Research article

Disseminating a smoking cessation intervention to childhood and young adult cancer survivors: baseline characteristics and study design of the partnership for health-2 study

Janet S de Moor, Elaine Puleo, Jennifer S Ford, Mark Greenberg, David C Hodgson, Vida L Tyc, Jamie Ostroff, Lisa R Diller, Andrea Gurmankin Levy, Kim Sprunck-Harrild, Karen M Emmons

Open Access Research article

The association of quality of life with potentially remediable disruptions of circadian sleep/activity rhythms in patients with advanced lung cancer

James F Grutsch, Carol Ferrans, Patricia A Wood, Jovelyn Du-Quiton, Dinah Faith T Quiton, Justin L Reynolds, Christine M Ansell, Eun Young Oh, Mary Ann Daehler, Robert D Levin, Donald P Braun, Digant Gupta, Christopher G Lis, William JM Hrushesky

Open Access Research article

Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4

Saskia E Rademakers, Jasper Lok, Albert J van der Kogel, Johan Bussink, Johannes HAM Kaanders

Open Access Case report

Extragenital Müllerian adenosarcoma with pouch of Douglas location

Tito S Patrelli, Enrico M Silini, Salvatore Gizzo, Roberto Berretta, Laura Franchi, Elena Thai, Adolf Lukanovic, Giovanni B Nardelli, Alberto Bacchi Modena

Open Access Research article

Analysis of the Mitogen-activated protein kinase kinase 4 (MAP2K4) tumor suppressor gene in ovarian cancer

Sally J Davis, David YH Choong, Manasa Ramakrishna, Georgina L Ryland, Ian G Campbell, Kylie L Gorringe

Open Access Research article

β-Elemene-induced autophagy protects human gastric cancer cells from undergoing apoptosis

Jing Liu, Ye Zhang, Jinglei Qu, Ling Xu, Kezuo Hou, Jingdong Zhang, Xiujuan Qu, Yunpeng Liu

Open Access Research article

MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer

Pan Jian, Tao Yanfang, Zhou Zhuan, Wang Jian, Zhu Xueming, Ni Jian

Open Access Research article

MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis

Yan Wan, Wei Wu, Zhihua Yin, Peng Guan, Baosen Zhou

Open Access Research article

Effects on quality of life, anti-cancer responses, breast conserving surgery and survival with neoadjuvant docetaxel: a randomised study of sequential weekly versus three-weekly docetaxel following neoadjuvant doxorubicin and cyclophosphamide in women with primary breast cancer

Leslie G Walker, Jennifer M Eremin, Mark M Aloysius, Wichai Vassanasiri, Mary B Walker, Mohamed El-Sheemy, Ged Cowley, Jeanette Beer, Srila Samphao, Janice Wiseman, Jibril A Jibril, David Valerio, David J Clarke, Mujahid Kamal, Gerald W Thorpe, Karin Baria, Oleg Eremin

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Genetic variation in DNA-repair pathways and response to radiochemotherapy in esophageal adenocarcinoma: a retrospective cohort study of the Eastern Cooperative Oncology Group

Harry H Yoon, Paul J Catalano, Kathleen M Murphy, Todd C Skaar, Santosh Philips, Mark Powell, Elizabeth A Montgomery, Michael J Hafez, Steven M Offer, Geoffrey Liu, Stephen J Meltzer, Xifeng Wu, Arlene A Forastiere, Al B Benson, Lawrence R Kleinberg, Michael K Gibson

Open Access Study protocol

Phase II study of induction chemotherapy with TPF followed by radioimmunotherapy with Cetuximab and intensity-modulated radiotherapy (IMRT) in combination with a carbon ion boost for locally advanced tumours of the oro-, hypopharynx and larynx - TPF-C-HIT

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Open Access Research article

Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: Role of uric acid accumulation in gemcitabine-induced MICA/B expression

Xiulong Xu, Geetha S Rao, Veronika Groh, Thomas Spies, Paolo Gattuso, Howard L Kaufman, Janet Plate, Richard A Prinz

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Process of distant lymph node metastasis in colorectal carcinoma: Implication of extracapsular invasion of lymph node metastasis

Takaaki Fujii, Yuichi Tabe, Reina Yajima, Satoru Yamaguchi, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano

Open Access Case report

Bilateral ovarian teratoma complicated with carcinosarcoma in a 68 year old woman: a case report

S Shanmughapriya, G SenthilKumar, K Balakrishnan, N Vasanthi, K Vinodhini, K Natarajaseenivasan

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SIP1 is downregulated in hepatocellular carcinoma by promoter hypermethylation

Tolga Acun, Emin Oztas, Tamer Yagci, Mustafa C Yakicier

Open Access Case report

Laryngeal embryonal rhabdomyosarcoma in an adult - A case presentation in the eyes of geneticists and clinicians

Wojciech Kukwa, Piotr Wojtowicz, Beata Jagielska, Grzegorz Sobczyk, Andrzej Kukwa, Anna M Czarnecka

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STAT6 expression in glioblastoma promotes invasive growth

Barbara C Merk, Jennifer L Owens, Maria-Beatriz S Lopes, Corinne M Silva, Isa M Hussaini

Open Access Case report

Interleukin-11-induced capillary leak syndrome in primary hepatic carcinoma patients with thrombocytopenia

Wang Kai-Feng, Pan Hong-Ming, Lou Hai-Zhou, Shen Li-Rong, Zhu Xi-Yan

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The synthetic peptide P111-136 derived from the C-terminal domain of heparin affin regulatory peptide inhibits tumour growth of prostate cancer PC-3 cells

Yamina Hamma-Kourbali, Oya Bermek, Isabelle Bernard-Pierrot, Racha Karaky, Dominique Martel-Renoir, Sophie Frechault, José Courty, Jean Delbé

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Y-box protein-1/p18 fragment identifies malignancies in patients with chronic liver disease

Frank Tacke, Nicolas Kanig, Abdelaziz En-Nia, Thilo Kaehne, Christiane S Eberhardt, Victoria Shpacovitch, Christian Trautwein, Peter R Mertens

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Diagnostic performance of contrast enhanced CT and 18F-FDG PET/CT in suspicious recurrence of biliary tract cancer after curative resection

Yun-Gyoo Lee, Sae-Won Han, Do-Youn Oh, Eui Kyu Chie, Jin-Young Jang, Seock-Ah Im, Tae-You Kim, Sun-Whe Kim, Sung Whan Ha, Yung-Jue Bang

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Overexpression of eIF-5A2 in mice causes accelerated organismal aging by increasing chromosome instability

Muhan Chen, Jian-Dong Huang, Hong Kui Deng, Suisui Dong, Wen Deng, Sze Lan Tsang, Michael SY Huen, Leilei Chen, Tong Zan, Gui-Xia Zhu, Xin-Yuan Guan

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Relevance of circulating nucleosomes and oncological biomarkers for predicting response to transarterial chemoembolization therapy in liver cancer patients

Nikolaus Kohles, Dorothea Nagel, Dietrich Jüngst, Jürgen Durner, Petra Stieber, Stefan Holdenrieder

Open Access Research article

P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation

Kelly A Avery-Kiejda, Nikola A Bowden, Amanda J Croft, Lyndee L Scurr, Carla F Kairupan, Katie A Ashton, Bente A Talseth-Palmer, Helen Rizos, Xu D Zhang, Rodney J Scott, Peter Hersey

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Prognostic significance of IL-6 and IL-8 ascites levels in ovarian cancer patients

Denis Lane, Isabelle Matte, Claudine Rancourt, Alain Piché

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Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Irene Centeno, Pilar Blay, Iñigo Santamaría, Aurora Astudillo, Ana S Pitiot, Fernando G Osorio, Patricia González-Arriaga, Fernando Iglesias, Primitiva Menéndez, Adonina Tardón, Jose M Freije, Milagros Balbín

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Mitochondrial targeted catalase suppresses invasive breast cancer in mice

Jorming Goh, Linda Enns, Soroosh Fatemie, Heather Hopkins, John Morton, Christina Pettan-Brewer, Warren Ladiges

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Complementary and alternative medicine use in oncology: A questionnaire survey of patients and health care professionals

Kah Hoong Chang, Rachel Brodie, Mei Ann Choong, Karl J Sweeney, Michael J Kerin

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Adaptation to HIF-1 deficiency by upregulation of the AMP/ATP ratio and phosphofructokinase activation in hepatomas

Monika Golinska, Helen Troy, Yuen-Li Chung, Paul M McSheehy, Manuel Mayr, Xiaoke Yin, Lucy Ly, Kaye J Williams, Rachel E Airley, Adrian L Harris, John Latigo, Meg Perumal, Eric O Aboagye, David Perrett, Marion Stubbs, John R Griffiths

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Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: Long-term results of a randomized controlled trial

Jurjen J Boonstra, Tjebbe C Kok, Bas PL Wijnhoven, Mark van Heijl, Mark I van Berge Henegouwen, Fiebo JW ten Kate, Peter D Siersema, Winand NM Dinjens, Jan JB van Lanschot, Hugo W Tilanus, Ate van der Gaast

Open Access Research article

Phase II study of the combination carboplatin plus celecoxib in heavily pre-treated recurrent ovarian cancer patients

Francesco Legge, Amelia Paglia, Marco D'Asta, Gilda Fuoco, Giovanni Scambia, Gabriella Ferrandina

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Cost-effectiveness of early detection of breast cancer in Catalonia (Spain)

Misericordia Carles, Ester Vilaprinyo, Francesc Cots, Aleix Gregori, Roger Pla, Rubén Román, Maria Sala, Francesc Macià, Xavier Castells, Montserrat Rue

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Re-surgery and chest wall re-irradiation for recurrent breast cancer - a second curative approach

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Systemic chemotherapy for treatment of advanced small bowel adenocarcinoma with prognostic factor analysis: retrospective study

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Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression

Chelsea R Tieszen, Alicia A Goyeneche, BreeAnn N Brandhagen, Casey T Ortbahn, Carlos M Telleria

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A short-term in vivo model for giant cell tumor of bone

Maurice Balke, Anna Neumann, Károly Szuhai, Konstantin Agelopoulos, Christian August, Georg Gosheger, Pancras CW Hogendoorn, Nick Athanasou, Horst Buerger, Martin Hagedorn

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Retrospective exploratory analysis of VEGF polymorphisms in the prediction of benefit from first-line FOLFIRI plus bevacizumab in metastatic colorectal cancer

Fotios Loupakis, Annamaria Ruzzo, Lisa Salvatore, Chiara Cremolini, Gianluca Masi, Paolo Frumento, Marta Schirripa, Vincenzo Catalano, Nadia Galluccio, Emanuele Canestrari, Bruno Vincenzi, Daniele Santini, Katia Bencardino, Vincenzo Ricci, Mariangela Manzoni, Marco Danova, Giuseppe Tonini, Mauro Magnani, Alfredo Falcone, Francesco Graziano

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Importance of pre-analytical steps for transcriptome and RT-qPCR analyses in the context of the phase II randomised multicentre trial REMAGUS02 of neoadjuvant chemotherapy in breast cancer patients

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The roles of herbal remedies in survival and quality of life among long-term breast cancer survivors - results of a prospective study

Huiyan Ma, Catherine L Carpenter, Jane Sullivan-Halley, Leslie Bernstein

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Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients

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Attenuated expression of HRH4 in colorectal carcinomas: a potential influence on tumor growth and progression

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MDM2 antagonist Nutlin-3a potentiates antitumour activity of cytotoxic drugs in sarcoma cell lines

Hege O Ohnstad, Erik B Paulsen, Paul Noordhuis, Marianne Berg, Ragnhild A Lothe, Lyubomir T Vassilev, Ola Myklebost

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Down regulation of E-Cadherin (ECAD) - a predictor for occult metastatic disease in sentinel node biopsy of early squamous cell carcinomas of the oral cavity and oropharynx

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NDRG2 inhibits hepatocellular carcinoma adhesion, migration and invasion by regulating CD24 expression

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Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens

Al Muktafi Sadi, Dong-Yu Wang, Bruce J Youngson, Naomi Miller, Scott Boerner, Susan J Done, Wey L Leong

Open Access Research article

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

Lucy Heinemann, Guy R Simpson, Angela Boxall, Timothy Kottke, Kate L Relph, Richard Vile, Alan Melcher, Robin Prestwich, Kevin J Harrington, Richard Morgan, Hardev S Pandha

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Lung cancer stage at diagnosis: Individual associations in the prospective VITamins and lifestyle (VITAL) cohort

Christopher G Slatore, Michael K Gould, David H Au, Mark E Deffebach, Emily White

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Detection of antibodies directed at M. hyorhinis p37 in the serum of men with newly diagnosed prostate cancer

Cydney Urbanek, Steve Goodison, Myron Chang, Stacy Porvasnik, Noburo Sakamoto, Chen-zhong Li, Susan K Boehlein, Charles J Rosser

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GP88 (PC-Cell Derived Growth Factor, progranulin) stimulates proliferation and confers letrozole resistance to aromatase overexpressing breast cancer cells

Tesfom Abrhale, Angela Brodie, Gauri Sabnis, Luciana Macedo, Changsheng Tian, Binbin Yue, Ginette Serrero

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Limited importance of the dominant-negative effect of TP53missense mutations

Ewelina Stoczynska-Fidelus, Malgorzata Szybka, Sylwester Piaskowski, Michal Bienkowski, Krystyna Hulas-Bigoszewska, Mateusz Banaszczyk, Izabela Zawlik, Dorota Jesionek-Kupnicka, Radzislaw Kordek, Pawel P Liberski, Piotr Rieske

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Prognostic value of the expression of C-Chemokine Receptor 6 and 7 and their ligands in non-metastatic breast cancer

Philippe A Cassier, Isabelle Treilleux, Thomas Bachelot, Isabelle Ray-Coquard, Nathalie Bendriss-Vermare, Christine Ménétrier-Caux, Olivier Trédan, Sophie Goddard-Léon, Jean-Jacques Pin, Hervé Mignotte, Clarisse Bathélémy-Dubois, Christophe Caux, Serge Lebecque, Jean-Yves Blay

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Neutrophilic airways inflammation in lung cancer: the role of exhaled LTB-4 and IL-8

Giovanna E Carpagnano, Grazia P Palladino, Donato Lacedonia, Anna Koutelou, Silvio Orlando, Maria P Foschino-Barbaro

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Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer

Antara Datta, Martin E Adelson, Yakov Mogilevkin, Eli Mordechai, Abraham A Sidi, Jason P Trama

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COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status

Annika Gustafsson Asting, Helena Carén, Marianne Andersson, Christina Lönnroth, Kristina Lagerstedt, Kent Lundholm

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Platelet factor-4 and its p17-70 peptide inhibit myeloma proliferation and angiogenesis in vivo

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Myofibrillogenesis regulator 1 (MR-1) is a novel biomarker and potential therapeutic target for human ovarian cancer

Renquan Lu, Min Sun, Jingjing Feng, Xiang Gao, Lin Guo

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A comprehensive candidate gene approach identifies genetic variation associated with osteosarcoma

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Open Access Research article

Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival

Sara Huerta-Yepez, Nam K Yoon, Angeles Hernandez-Cueto, Vei Mah, Clara M Rivera-Pazos, Devasis Chatterjee, Mario I Vega, Erin L Maresh, Steve Horvath, David Chia, Benjamin Bonavida, Lee Goodglick

Open Access Research article

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

Sue Youn Kim, Jiyeon Yoon, Young San Ko, Mee Soo Chang, Jong-Wan Park, Hee Eun Lee, Min A Kim, Ji Hun Kim, Woo Ho Kim, Byung Lan Lee

Open Access Research article

Lung cancer in HIV patients and their parents: A Danish cohort study

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Low expression of aldehyde deyhdrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer

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Literature survey on epidemiology and pathology of gangliocytic paraganglioma

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Open Access Case report

Cervical Mullerian Adenosarcoma with heterologous sarcomatous overgrowth: a fourth case and review of literature

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Open Access Study protocol

Efficacy of a referral and physical activity program for survivors of prostate cancer [ENGAGE]: Rationale and design for a cluster randomised controlled trial

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Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study

Ju-Fang Shi, Karen Canfell, Jie-Bin Lew, Fang-Hui Zhao, Rosa Legood, Yan Ning, Leonardo Simonella, Li Ma, Yoon-Jung Kang, Yong-Zhen Zhang, Megan A Smith, Jun-Feng Chen, Xiang-Xian Feng, You-Lin Qiao

Open Access Research article

Magnetic resonance imaging for lung cancer detection: Experience in a population of more than 10,000 healthy individuals

Nai-Yuan Wu, Hui-Cheng Cheng, James S Ko, Yu-Chen Cheng, Po-Wei Lin, Wei-Chan Lin, Cheng-Yen Chang, Der-Ming Liou

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Renal cell carcinoma primary cultures maintain genomic and phenotypic profile of parental tumor tissues

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Open Access Research article

FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells

Hyung-Ok Lee, Stefanie R Mullins, Janusz Franco-Barraza, Matthildi Valianou, Edna Cukierman, Jonathan D Cheng

Open Access Research article

c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells

Yinghua Chen, Jinhua Xu, Stanley Borowicz, Cindy Collins, Dezheng Huo, Olufunmilayo I Olopade

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PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib

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Open Access Research article

Healthcare costs in women with metastatic breast cancer receiving chemotherapy as their principal treatment modality

Montserrat Vera-Llonch, Derek Weycker, Andrew Glass, Sue Gao, Rohit Borker, Angie Qin, Gerry Oster

Open Access Research article

Prognostic value of hematogenous dissemination and biological profile of the tumor in early breast cancer patients: A prospective observational study

Montserrat Solá, Mireia Margelí, Eva Castellá, Juan F Julian, Miquel Rull, Josep M Gubern, Antonio Mariscal, Agustí Barnadas, Manuel Fraile

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Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma

Jian Ma, Shuiliang Wang, Ming Zhao, Xin-Sheng Deng, Choon-Kee Lee, Xiao-Dan Yu, Bolin Liu

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Gβγ subunits inhibit Epac-induced melanoma cell migration

Erdene Baljinnyam, Masanari Umemura, Mariana S De Lorenzo, Lai-Hua Xie, Martha Nowycky, Mizuka Iwatsubo, Suzie Chen, James S Goydos, Kousaku Iwatsubo

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Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas

Peeter Karihtala, Saila Kauppila, Ylermi Soini, Arja-Jukkola-Vuorinen

Open Access Research article

Expression of Tissue factor in Adenocarcinoma and Squamous Cell Carcinoma of the Uterine Cervix: Implications for immunotherapy with hI-con1, a factor VII-IgGFcchimeric protein targeting tissue factor

Emiliano Cocco, Joyce Varughese, Natalia Buza, Stefania Bellone, Michelle Glasgow, Marta Bellone, Paola Todeschini, Luisa Carrara, Dan-Arin Silasi, Masoud Azodi, Peter E Schwartz, Thomas J Rutherford, Sergio Pecorelli, Charles J Lockwood, Alessandro D Santin

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Adjuvant Radio-chemotherapy for extrahepatic biliary tract cancers

Marta Bonet Beltrán, Arnaud D Roth, Gilles Mentha, Abdelkarim S Allal

Open Access Research article

Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation

Eleanor I Ager, Shu Wen Wen, Joyna Chan, Way W Chong, Jaclyn H Neo, Christopher Christophi

Open Access Case report

Peritoneal lymphomatosis confounded by prior history of colon cancer: a case report

Yun Gi Kim, Ji Yeon Baek, Sun Young Kim, Dong Hyeon Lee, Weon Seo Park, Youngmee Kwon, Min Ju Kim, Jeehoon Kang, Joo Myung Lee

Open Access Research article

Underuse of long-term routine hospital follow-up care in patients with a history of breast cancer?

Wenli Lu, Liesbeth Jansen, Michael Schaapveld, Peter C Baas, Theo Wiggers, Geertruida H De Bock

Open Access Research article

Regulation of gene expression in ovarian cancer cells by luteinizing hormone receptor expression and activation

Juan Cui, Brooke M Miner, Joanna B Eldredge, Susanne W Warrenfeltz, Phuongan Dam, Ying Xu, David Puett

Open Access Research article

Protein expression based multimarker analysis of breast cancer samples

Angela P Presson, Nam K Yoon, Lora Bagryanova, Vei Mah, Mohammad Alavi, Erin L Maresh, Ayyappan K Rajasekaran, Lee Goodglick, David Chia, Steve Horvath

Open Access Research article

Sociodemographic gradients in breast and cervical cancer screening in Korea: the Korean National Cancer Screening Survey (KNCSS) 2005-2009

Mi Jin Park, Eun-Cheol Park, Kui Son Choi, Jae Kwan Jun, Hoo-Yeon Lee

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Clinicopathological and prognostic significance of HER-2/neu and VEGF expression in colon carcinomas

Qingguo Li, Daorong Wang, Jing Li, Ping Chen

Open Access Research article

Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer

Nuh N Rahbari, Thomas Schmidt, Christine S Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W Büchler, Jürgen Weitz, Moritz Koch

Open Access Research article

Gain of DNA methylation is enhanced in the absence of CTCF at the human retinoblastoma gene promoter

Mercedes Dávalos-Salas, Mayra Furlan-Magaril, Edgar González-Buendía, Christian Valdes-Quezada, Erandi Ayala-Ortega, Félix Recillas-Targa

Open Access Research article

Zinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis

Qing Wang, Ye-xiong Tan, Yi-bin Ren, Li-wei Dong, Zhi-fang Xie, Liang Tang, Dan Cao, Wei-ping Zhang, He-ping Hu, Hong-yang Wang

Open Access Research article

ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner

Navin R Mahadevan, Jeffrey Rodvold, Gonzalo Almanza, Antonio Fernández Pérez, Matthew C Wheeler, Maurizio Zanetti

Open Access Commentary

Screening for cervical cancer: when theory meets reality

Mari Nygård

Open Access Technical advance

A high-throughput protocol for mutation scanning of the BRCA1 and BRCA2genes

Heather L Hondow, Stephen B Fox, Gillian Mitchell, Rodney J Scott, Victoria Beshay, Stephen Q Wong, Alexander Dobrovic

Open Access Research article

Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice

Melpo Christofidou-Solomidou, Sonia Tyagi, Kay-See Tan, Sarah Hagan, Ralph Pietrofesa, Floyd Dukes, Evguenia Arguiri, Daniel F Heitjan, Charalambos C Solomides, Keith A Cengel

Open Access Research article

Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk

Luisel J Ricks-Santi, Lara E Sucheston, Yang Yang, Jo L Freudenheim, Claudine J Isaacs, Marc D Schwartz, Ramona G Dumitrescu, Catalin Marian, Jing Nie, Dominica Vito, Stephen B Edge, Peter G Shields

Open Access Research article

Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/dbobese mice

Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki

Open Access Study protocol

The use of erlotinib in daily practice: a study on adherence and patients' experiences

Lonneke Timmers, Christel CLM Boons, Dirk Mangnus, Josee E Moes, Eleonora L Swart, Epie Boven, Egbert F Smit, Jacqueline G Hugtenburg

Open Access Research article

Cost-analysis of XELOX and FOLFOX4 for treatment of colorectal cancer to assist decision-making on reimbursement

Vicki C Tse, Wai Tong Ng, Victor Lee, Anne WM Lee, Daniel TT Chua, June Chau, Sarah M McGhee

Open Access Research article

Differences in integrin expression and signaling within human breast cancer cells

Aliakbar Taherian, Xinlei Li, Yongqing Liu, Thomas A Haas

Open Access Research article

Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts

Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki, Kazuki Nabeshima

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Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects

Rita Ferla, Maria Bonomi, Laszlo Otvos Jr, Eva Surmacz

Open Access Research article

Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma

Hajime Tamura, Makoto Suzuki, Yasumitsu Moriya, Hidehisa Hoshino, Tatsuro Okamoto, Shigetoshi Yoshida, Ichiro Yoshino

Open Access Research article

Trends in colorectal cancer incidence: a period and birth-cohort analysis in a well-defined French population

Marion Chauvenet, Vanessa Cottet, Côme Lepage, Valérie Jooste, Jean Faivre, Anne-Marie Bouvier

Open Access Research article

An intracellular targeted antibody detects EGFR as an independent prognostic factor in ovarian carcinomas

Aurelia Noske, Michael Schwabe, Wilko Weichert, Silvia Darb-Esfahani, Ann-Christin Buckendahl, Jalid Sehouli, Elena I Braicu, Jan Budczies, Manfred Dietel, Carsten Denkert

Open Access Study protocol

Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastric junction (AEG): The Heidelberg Imaging program in Cancer of the oesophago-gastric junction during Neoadjuvant treatment: HICON trial

Sylvie Lorenzen, Carl von Gall, Annika Stange, Georg M Haag, Jürgen Weitz, Uwe Haberkorn, Florian Lordick, Wilko Weichert, Ulrich Abel, Jürgen Debus, Dirk Jäger, Marc W Münter

Open Access Study protocol

Simultaneous integrated boost for adjuvant treatment of breast cancer- intensity modulated vs. conventional radiotherapy: The IMRT-MC2 trial

Vasileios Askoxylakis, Alexandra D Jensen, Matthias F Häfner, Leonie Fetzner, Florian Sterzing, Joerg Heil, Christof Sohn, Johannes Hüsing, Uta Tiefenbacher, Frederik Wenz, Jürgen Debus, Holger Hof

Open Access Study protocol

Effect of a low fat versus a low carbohydrate weight loss dietary intervention on biomarkers of long term survival in breast cancer patients ('CHOICE'): study protocol

Scot M Sedlacek, Mary C Playdon, Pamela Wolfe, John N McGinley, Mark R Wisthoff, Elizabeth A Daeninck, Weiqin Jiang, Zongjian Zhu, Henry J Thompson

Open Access Software

A simple method for assigning genomic grade to individual breast tumours

Kristian Wennmalm, Jonas Bergh

Open Access Research article

Measuring cancer care coordination: development and validation of a questionnaire for patients

Jane M Young, Jennifer Walsh, Phyllis N Butow, Michael J Solomon, Joanne Shaw

Open Access Research article

Nottingham Prognostic Index in Triple-Negative Breast Cancer: a reliable prognostic tool?

André Albergaria, Sara Ricardo, Fernanda Milanezi, Vítor Carneiro, Isabel Amendoeira, Daniella Vieira, Jorge Cameselle-Teijeiro, Fernando Schmitt

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Combined mRNA expression levels of members of the urokinase plasminogen activator (uPA) system correlate with disease-associated survival of soft-tissue sarcoma patients

Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl, Helge Taubert

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Dose and polymorphic genes xrcc1, xrcc3, gst play a role in the risk of developing erythema in breast cancer patients following single shot partial breast irradiation after conservative surgery

Elisabetta Falvo, Lidia Strigari, Gennaro Citro, Carolina Giordano, Stefano Arcangeli, Antonella Soriani, Daniela D'Alessio, Paola Muti, Giovanni Blandino, Isabella Sperduti, Paola Pinnarò

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Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma

Jonas Busch, Christoph Seidel, Steffen Weikert, Ingmar Wolff, Carsten Kempkensteffen, Lisa Weinkauf, Stefan Hinz, Ahmed Magheli, Kurt Miller, Viktor Grünwald

Open Access Research article

Protein-bound polysaccharide from Phellinus linteus inhibits tumor growth, invasion, and angiogenesis and alters Wnt/β-catenin in SW480 human colon cancer cells

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Open Access Research article

E7080, a multi-targeted tyrosine kinase inhibitor suppresses tumor cell migration and invasion

Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod, Valerie G Brunton

Open Access Research article

Radiotherapy may improve overall survival of patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter and delay bladder tumour relapse

Bing Chen, Zhao-Chong Zeng, Guo-Min Wang, Li Zhang, Zong-Ming Lin, Li-An Sun, Tong-Yu Zhu, Li-Li Wu, Jian-Ying Zhang, Yuan Ji

Open Access Research article

A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

Fabiana A Serrano, Alisson L Matsuo, Priscila T Monteforte, Alexandre Bechara, Soraya S Smaili, Débora P Santana, Tiago Rodrigues, Felipe V Pereira, Luis S Silva, Joel Machado Jr, Edson L Santos, João B Pesquero, Rafael M Martins, Luiz R Travassos, Antonio CF Caires, Elaine G Rodrigues

Open Access Technical advance

High resolution melting analysis for a rapid identification of heterozygous and homozygous sequence changes in the MUTYH gene

Rossella Tricarico, Francesca Crucianelli, Antonio Alvau, Claudio Orlando, Roberta Sestini, Francesco Tonelli, Rosa Valanzano, Maurizio Genuardi

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Integrated genomics of ovarian xenograft tumor progression and chemotherapy response

Ashley Stuckey, Andrew Fischer, Daniel H Miller, Sara Hillenmeyer, Kyu K Kim, Anna Ritz, Rakesh K Singh, Benjamin J Raphael, Laurent Brard, Alexander S Brodsky

Open Access Study protocol

Open versus laparoscopically-assisted oesophagectomy for cancer: a multicentre randomised controlled phase III trial - the MIRO trial

Nicolas Briez, Guillaume Piessen, Franck Bonnetain, Cécile Brigand, Nicolas Carrere, Denis Collet, Christophe Doddoli, Renaud Flamein, Jean-Yves Mabrut, Bernard Meunier, Simon Msika, Thierry Perniceni, Frédérique Peschaud, Michel Prudhomme, Jean-Pierre Triboulet, Christophe Mariette

Open Access Research article

Distinct distribution and prognostic significance of molecular subtypes of breast cancer in Chinese women: a population-based cohort study

Yinghao Su, Ying Zheng, Wei Zheng, Kai Gu, Zhi Chen, Guoliang Li, Qiuyin Cai, Wei Lu, Xiao Ou Shu

Open Access Research article

Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer

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Open Access Research article

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7

Xin Jian Fang, Hua Jiang, Xv Peng Zhao, Wei Mei Jiang

Open Access Research article

Cyclic AMP induces apoptosis in multiple myeloma cells and inhibits tumor development in a mouse myeloma model

Virginie Follin-Arbelet, Peter O Hofgaard, Harald Hauglin, Soheil Naderi, Anders Sundan, Rune Blomhoff, Bjarne Bogen, Heidi K Blomhoff

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Dusan Kotasek, Niall Tebbutt, Jayesh Desai, Stephen Welch, Lillian L Siu, Sheryl McCoy, Yu-Nien Sun, Jessica Johnson, Adeboye H Adewoye, Timothy Price

Open Access Research article

Heparin based prophylaxis to prevent venous thromboembolic events and death in patients with cancer - a subgroup analysis of CERTIFY

Sylvia Haas, Sebastian M Schellong, Ulrich Tebbe, Horst-Eberhard Gerlach, Rupert Bauersachs, Nima Melzer, Claudia Abletshauser, Christian Sieder, Peter Bramlage, Hanno Riess

Open Access Study protocol

Living with prostate cancer: randomised controlled trial of a multimodal supportive care intervention for men with prostate cancer

Suzanne K Chambers, Robert U Newton, Afaf Girgis, Lisa Nielsen, Stephen Lepore, Cathrine Mihalopoulos, RA Gardiner, Daniel A Galvão, Stefano Occhipinti

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CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma

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Open Access Research article

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Seok Jin Kim, Chul Won Choi, Yeung-Chul Mun, Sung Yong Oh, Hye Jin Kang, Soon Il Lee, Jong Ho Won, Min Kyoung Kim, Jung Hye Kwon, Jin Seok Kim, Jae-Yong Kwak, Jung Mi Kwon, In Gyu Hwang, Hyo Jung Kim, Jae Hoon Lee, Sukjoong Oh, Keon Woo Park, Cheolwon Suh, Won Seog Kim

Open Access Research article

5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells

Zhao-Hui Xie, Mei-Fang Quan, Fei Liu, Jian-Guo Cao, Jian-Song Zhang

Open Access Case report

Primary leiomyosarcoma of the seminal vesicle: Case report and review of the literature

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Open Access Research article

NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene

Henna Mattila, Martin Schindler, Jarkko Isotalo, Tarja Ikonen, Mauno Vihinen, Hannu Oja, Teuvo LJ Tammela, Tiina Wahlfors, Johanna Schleutker

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Barbara Peric, Ivana Zagar, Srdjan Novakovic, Janez Zgajnar, Marko Hocevar

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A comparison of breast density measures between mothers and adolescent daughters

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The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy

Byung-Hoon Min, Jeong Mo Bae, Eui Jin Lee, Hong Suk Yu, Young-Ho Kim, Dong Kyung Chang, Hee Cheol Kim, Cheol Keun Park, Suk-Hee Lee, Kyoung-Mee Kim, Gyeong Hoon Kang

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Demographic variation in incidence of adult glioma by subtype, United States, 1992-2007

Robert Dubrow, Amy S Darefsky

Open Access Research article

Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas

Vilde D Haakensen, Trine Bjøro, Torben Lüders, Margit Riis, Ida K Bukholm, Vessela N Kristensen, Melissa A Troester, Marit M Homen, Giske Ursin, Anne-Lise Børresen-Dale, Åslaug Helland

Open Access Research article

Ki67 proliferation in core biopsies versus surgical samples - a model for neo-adjuvant breast cancer studies

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Open Access Research article

Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas

Spyros S Skandalis, Vassiliki T Labropoulou, Panagiota Ravazoula, Eleni Likaki-Karatza, Katalin Dobra, Haralabos P Kalofonos, Nikos K Karamanos, Achilleas D Theocharis

Open Access Research article

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy

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Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type

Bernard Krust, Diala El Khoury, Isabelle Nondier, Calaiselvy Soundaramourty, Ara G Hovanessian

Open Access Research article

Involvement of Cox-2 in the metastatic potential of chemotherapy-resistant breast cancer cells

Ju-Hee Kang, Ki-Hoon Song, Kyung-Chae Jeong, Sunshin Kim, Changsun Choi, Chang Hoon Lee, Seung Hyun Oh

Open Access Research article

Matched-pair analysis of patients with female and male breast cancer: a comparative analysis

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Open Access Case report

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Open Access Study protocol

Rationale and design of DECISION: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patients with locally advanced or metastatic radioactive iodine (RAI)-refractory, differentiated thyroid cancer

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Lin Li, Walter J Psoter, Carmen J Buxó, Augusto Elias, Lumarie Cuadrado, Douglas E Morse

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MMP-1 expression has an independent prognostic value in breast cancer

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Open Access Case report

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Open Access Research article

Quality of life assessment as a predictor of survival in non-small cell lung cancer

Donald P Braun, Digant Gupta, Edgar D Staren

Open Access Research article

Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

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A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells

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Factors determining the survival of nasopharyngeal carcinoma with lung metastasis alone: does combined modality treatment benefit?

Xun Cao, Li-Ru He, Fang-Yun Xie, You-Fang Chen, Zhe-Sheng Wen

Open Access Research article

Molecular targeting of prostate cancer cells by a triple drug combination down-regulates integrin driven adhesion processes, delays cell cycle progression and interferes with the cdk-cyclin axis

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Open Access Research article

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling

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Open Access Research article

Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression

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Accuracy of perfusion MRI with high spatial but low temporal resolution to assess invasive breast cancer response to neoadjuvant chemotherapy: a retrospective study

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Open Access Study protocol

A randomized, phase III trial of capecitabine plus bevacizumab (Cape-Bev) versus capecitabine plus irinotecan plus bevacizumab (CAPIRI-Bev) in first-line treatment of metastatic colorectal cancer: The AIO KRK 0110 Trial/ML22011 Trial

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Open Access Study protocol

Progressive Resistance Training and Cancer Testis (PROTRACT) - Efficacy of resistance training on muscle function, morphology and inflammatory profile in testicular cancer patients undergoing chemotherapy: design of a randomized controlled trial

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Open Access Study protocol

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Open Access Research article

Kinetic Targeting of pegylated liposomal Doxorubicin: a new Approach to Reduce Toxicity during Chemotherapy (CARL-trial)

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Open Access Research article

Case-control study for colorectal cancer genetic susceptibility in EPICOLON: previously identified variants and mucins

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Open Access Study protocol

Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter phase III study (NEOPAC study)

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Open Access Research article

Early dissemination of bevacizumab for advanced colorectal cancer: a prospective cohort study

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Open Access Research article

Downregulation of TFPI in breast cancer cells induces tyrosine phosphorylation signaling and increases metastatic growth by stimulating cell motility

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Open Access Research article

Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

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Open Access Research article

The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma

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Expression of Transketolase like gene 1 (TKTL1) predicts disease-free survival in patients with locally advanced rectal cancer receiving neoadjuvant chemoradiotherapy

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Open Access Research article

Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers

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Open Access Research article

The association between socio-demographic characteristics and adherence to breast and colorectal cancer screening: Analysis of large sub populations

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Open Access Research article

EFS shows biallelic methylation in uveal melanoma with poor prognosis as well as tissue-specific methylation

Lisa C Neumann, Andreas Weinhäusel, Stefanie Thomas, Bernhard Horsthemke, Dietmar R Lohmann, Michael Zeschnigk

Open Access Research article

Phase II study of weekly paclitaxel and capecitabine in patients with metastatic or recurrent esophageal squamous cell carcinoma

Tak Yun, Ji-Youn Han, Jin Soo Lee, Hyun Lee Choi, Hyae Young Kim, Byung-Ho Nam, Heung Tae Kim

Open Access Research article

An examination of cancer-related fatigue through proposed diagnostic criteria in a sample of cancer patients in Taiwan

En-Tien Yeh, Shu-Chuen Lau, Wei-Ju Su, Duu-Jian Tsai, Ying-Yueh Tu, Yuen-Liang Lai

Open Access Research article

Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream of Death receptor-3

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Open Access Research article

A Nation-Wide multicenter 10-year (1999-2008) retrospective clinical epidemiological study of female breast cancer in china

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Open Access Research article

Single-agent pegylated liposomal doxorubicin (PLD) in the treatment of metastatic breast cancer: results of an Austrian observational trial

Michael Fiegl, Brigitte Mlineritsch, Michael Hubalek, Rupert Bartsch, Ursula Pluschnig, Günther G Steger

Open Access Research article

Oxidative stress and antioxidant status in primary bone and soft tissue sarcoma

Fatima M Nathan, Vivek A Singh, Amreeta Dhanoa, Uma D Palanisamy

Open Access Research article

A novel inhibitor of hypoxia-inducible factor-1α P3155 also modulates PI3K pathway and inhibits growth of prostate cancer cells

Sonal M Manohar, Amol A Padgaonkar, Archana Jalota-Badhwar, Vinay Sonawane, Maggie J Rathos, Sanjay Kumar, Kalpana S Joshi

Open Access Research article

Collagen induced arthritis increases secondary metastasis in MMTV-PyV MT mouse model of mammary cancer

Lopamudra Das Roy, Sriparna Ghosh, Latha B Pathangey, Teresa L Tinder, Helen E Gruber, Pinku Mukherjee

Open Access Research article

Clinical management of gastric cancer: results of a multicentre survey

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Antioxidants and breast cancer risk- a population-based case-control study in Canada

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Open Access Study protocol

Standard versus prosocial online support groups for distressed breast cancer survivors: a randomized controlled trial

Stephen J Lepore, Joanne S Buzaglo, Morton A Lieberman, Mitch Golant, Adam Davey

Open Access Research article

Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary thyroid carcinoma

Ou Huang, WeiLi Wu, OuChen Wang, Jie You, Quan Li, DuPing Huang, XiaoQu Hu, JinMiao Qu, Cun Jin, YouQun Xiang, Kai Yang, ShuMei Zhou, XueMin Chen, YiFei Pan, GuiLong Guo, XiaoHua Zhang

Open Access Research article

Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

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Open Access Research article

Overexpression of carbonic anhydrase and HIF-1α in Wilms tumours

Josiah V Dungwa, Linda P Hunt, Pramila Ramani

Open Access Research article

The hOGG1 Ser326Cys polymorphism and prostate cancer risk: a meta-analysis of 2584 cases and 3234 controls

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Open Access Research article

Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: A case control study

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Open Access Research article

Younger age as a prognostic indicator in breast cancer: A cohort study

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Open Access Research article

Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer

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Open Access Research article

Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B

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Open Access Research article

Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer

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Assessing awareness of colorectal cancer symptoms: Measure development and results from a population survey in the UK

Emily Power, Alice Simon, Dorota Juszczyk, Sara Hiom, Jane Wardle

Open Access Research article

Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: A tangible union against chemoresistant cancer

Preetinder P Singh, Swapna Joshi, Pamela J Russell, Sham Nair, Aparajita Khatri

Open Access Research article

ICOS gene polymorphisms are associated with sporadic breast cancer: a case-control study

Fengyan Xu, Dalin Li, Qiujin Zhang, Zhenkun Fu, Jie Zhang, Weiguang Yuan, Shuang Chen, Da Pang, Dianjun Li

Open Access Research article

Brain metastases from breast cancer: prognostic significance of HER-2 overexpression, effect of trastuzumab and cause of death

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Ulrike Boehmer, Al Ozonoff, Xiaopeng Miao

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An investigation of the apparent breast cancer epidemic in France: screening and incidence trends in birth cohorts

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Open Access Research article

Unstaged cancer in the United States: a population-based study

Ray M Merrill, Arielle Sloan, Allison E Anderson, Karem Ryker

Open Access Research article

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation

Sandra Sernbo, Elin Gustavsson, Donal J Brennan, William M Gallagher, Elton Rexhepaj, Frida Rydnert, Karin Jirström, Carl AK Borrebaeck, Sara Ek

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A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis

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Snail1 induces epithelial-to-mesenchymal transition and tumor initiating stem cell characteristics

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P53 suppresses expression of the 14-3-3gamma oncogene

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Open Access Research article

Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study

Annemieke WJ Opstal-van Winden, Esmeralda JM Krop, Monica H Kåredal, Marie-Christine W Gast, Christian H Lindh, Marina C Jeppsson, Bo AG Jönsson, Diederick E Grobbee, Petra HM Peeters, Jos H Beijnen, Carla H van Gils, Roel CH Vermeulen

Open Access Research article

Safety, feasibility and effects of an individualised walking intervention for women undergoing chemotherapy for ovarian cancer: a pilot study

Melissa J Newton, Sandi C Hayes, Monika Janda, Penelope M Webb, Andreas Obermair, Elizabeth G Eakin, David Wyld, Louisa G Gordon, Vanessa L Beesley

Open Access Research article

Tracking human multiple myeloma xenografts in NOD-Rag-1/IL-2 receptor gamma chain-null mice with the novel biomarker AKAP-4

Leonardo Mirandola, Yuefei Yu, Marjorie R Jenkins, Raffaella Chiaramonte, Everardo Cobos, Constance M John, Maurizio Chiriva-Internati

Open Access Research article

Knowledge and attitudes of primary healthcare patients regarding population-based screening for colorectal cancer

Maria Ramos, Maria Llagostera, Magdalena Esteva, Elena Cabeza, Xavier Cantero, Manel Segarra, Maria Martín-Rabadán, Guillem Artigues, Maties Torrent, Joana Maria Taltavull, Joana Maria Vanrell, Mercè Marzo, Joan Llobera

Open Access Research article

The extramural metastasis might be categorized in lymph node staging for colorectal cancer

Hai-Bo Qiu, Gong Chen, Rajiv P Keshari, Hui-Yan Luo, Wang Fang, Miao-Zhen Qiu, Zhi-Wei Zhou, Rui-Hua Xu

Open Access Research article

An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients

Riguel J Inaoka, Achim A Jungbluth, Otávio CG Baiocchi, Mariane CG Assis, Nicole C Hanson, Denise Frosina, Jodie Tassello, Adriana B Bortoluzzo, Antonio C Alves, Gisele WB Colleoni

Open Access Research article

Semiallogenic fusions of MSI+tumor cells and activated B cells induce MSI-specific T cell responses

Yvette Garbe, Ulrike Klier, Michael Linnebacher

Open Access Research article

Clinical pharmacogenomic testing of KRAS, BRAF and EGFRmutations by high resolution melting analysis and ultra-deep pyrosequencing

Emma Borràs, Ismael Jurado, Imma Hernan, María José Gamundi, Miguel Dias, Isabel Martí, Begoña Mañé, Àngels Arcusa, José AG Agúndez, Miguel Blanca, Miguel Carballo

Open Access Research article

Cyclin D1, Id1 and EMT in breast cancer

Nicholas P Tobin, Andrew H Sims, Katja L Lundgren, Sophie Lehn, Göran Landberg

Open Access Study protocol

A randomized controlled trial to investigate the influence of low dose radiotherapy on immune stimulatory effects in liver metastases of colorectal cancer

Christoph Reissfelder, Carmen Timke, Hubertus Schmitz-Winnenthal, Nuh N Rahbari, Moritz Koch, Felix Klug, Falk Roeder, Lutz Edler, Jürgen Debus, Markus W Büchler, Philipp Beckhove, Peter E Huber, Jürgen Weitz

Open Access Study protocol

A multilevel investigation of inequalities in clinical and psychosocial outcomes for women after breast cancer

Philippa H Youl, Peter D Baade, Joanne F Aitken, Suzanne K Chambers, Gavin Turrell, Christopher Pyke, Jeffrey Dunn

Open Access Research article

Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving "metronomic" zoledronic acid

Xinmin Zhao, Xiaofeng Xu, Qunling Zhang, Zhen Jia, Si Sun, Jian Zhang, Biyun Wang, Zhonghua Wang, Xichun Hu

Open Access Research article

Role of protein kinase C and epidermal growth factor receptor signalling in growth stimulation by neurotensin in colon carcinoma cells

Kristin M Müller, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Mona Dawood, Olav Dajani, Thoralf Christoffersen, Dagny L Sandnes

Open Access Research article

Defining the optimal dose of radiation in leukemic patients with extramedullary lesions

Jin Ho Song, Seok Hyun Son, Ju Hwan Lee, Su Mi Chung, Hong Seok Jang, Byung Ock Choi

Open Access Research article

Exposure to statins and risk of common cancers: a series of nested case-control studies

Yana Vinogradova, Carol Coupland, Julia Hippisley-Cox

Open Access Research article

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers

Eleonor Olsson, Gabriella Honeth, Pär-Ola Bendahl, Lao H Saal, Sofia Gruvberger-Saal, Markus Ringnér, Johan Vallon-Christersson, Göran Jönsson, Karolina Holm, Kristina Lövgren, Mårten Fernö, Dorthe Grabau, Åke Borg, Cecilia Hegardt

Open Access Research article

Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma

Song Wu, Yong Wang, Liang Sun, Zhiling Zhang, Zhimao Jiang, Zike Qin, Hui Han, Zhuowei Liu, Xianxin Li, Aifa Tang, Yaoting Gui, Zhiming Cai, Fangjian Zhou

Open Access Research article

The time since last menstrual period is important as a clinical predictor for non-steroidal aromatase inhibitor-related arthralgia

Miyuki Kanematsu, Masami Morimoto, Junko Honda, Taeko Nagao, Misako Nakagawa, Masako Takahashi, Akira Tangoku, Mitsunori Sasa

Open Access Research article

A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence

Patricia P Reis, Levi Waldron, Bayardo Perez-Ordonez, Melania Pintilie, Natalie Naranjo Galloni, Yali Xuan, Nilva K Cervigne, Giles C Warner, Antti A Makitie, Colleen Simpson, David Goldstein, Dale Brown, Ralph Gilbert, Patrick Gullane, Jonathan Irish, Igor Jurisica, Suzanne Kamel-Reid

Open Access Research article

Intraoperative radiotherapy electron boost in advanced and recurrent epithelial ovarian carcinoma: a retrospective study

Ying Gao, Zi Liu, Xi Chen, Wei Luo, Long Zhang, Juan Wang

Open Access Research article

Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

Mélissa Labelle-Côté, Julie Dusseault, Salma Ismaïl, Aude Picard-Cloutier, Peter M Siegel, Louise Larose

Open Access Research article

Aurora kinases are expressed in medullary thyroid carcinoma (MTC) and their inhibition suppresses in vitro growth and tumorigenicity of the MTC derived cell line TT

Enke Baldini, Yannick Arlot-Bonnemains, Salvatore Sorrenti, Caterina Mian, Maria R Pelizzo, Enrico De Antoni, Silvio Palermo, Stefania Morrone, Susi Barollo, Angela Nesca, Costanzo G Moretti, Massimino D'Armiento, Salvatore Ulisse

Open Access Case report

Efficacy of epidermal growth factor receptor targeting in advanced chordoma: case report and literature review

Simon G Launay, Bruno Chetaille, Fanny Medina, Delphine Perrot, Serge Nazarian, Jérôme Guiramand, Laurence Moureau-Zabotto, François Bertucci

Open Access Research article

Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection?

Nicole G Chau, Ana Florescu, Kelvin K Chan, Lisa Wang, Eric X Chen, Philippe Bedard, Amit M Oza, Lillian L Siu

Open Access Research article

Serum levels of selenium and smoking habits at age 50 influence long term prostate cancer risk; a 34 year ULSAM follow-up

Birgitta Grundmark, Björn Zethelius, Hans Garmo, Lars Holmberg

Open Access Research article

Activating mutation in MET oncogene in familial colorectal cancer

Deborah W Neklason, Michelle W Done, Nykole R Sargent, Ann G Schwartz, Hoda Anton-Culver, Constance A Griffin, Dennis J Ahnen, Joellen M Schildkraut, Gail E Tomlinson, Louise C Strong, Alexander R Miller, Jill E Stopfer, Randall W Burt

Open Access Research article

Double sampling of a faecal immunochemical test is not superior to single sampling for detection of colorectal neoplasia: a colonoscopy controlled prospective cohort study

Frank A Oort, Sietze T van Turenhout, Veerle MH Coupé, René WM van der Hulst, Eric IC Wesdorp, Jochim S Terhaar sive Droste, Ilhame Ben Larbi, Shannon L Kanis, Edwin van Hengel, Anneke A Bouman, Gerrit A Meijer, Chris JJ Mulder

Open Access Study protocol

INSPIRE: A phase III study of the BLP25 liposome vaccine (L-BLP25) in Asian patients with unresectable stage III non-small cell lung cancer

Yi-Long Wu, Keunchil Park, Ross A Soo, Yan Sun, Karin Tyroller, David Wages, Guy Ely, James Chih-Hsin Yang, Tony Mok

Open Access Research article

Granulocyte colony-stimulating factors for febrile neutropenia prophylaxis following chemotherapy: systematic review and meta-analysis

Katy L Cooper, Jason Madan, Sophie Whyte, Matt D Stevenson, Ron L Akehurst

Open Access Research article

A novel splice variant of the stem cell marker LGR5/GPR49 is correlated with the risk of tumor-related death in soft-tissue sarcoma patients

Swetlana Rot, Helge Taubert, Matthias Bache, Thomas Greither, Peter Würl, Alexander W Eckert, Johannes Schubert, Dirk Vordermark, Matthias Kappler

Open Access Research article

HNF1α inhibition triggers epithelial-mesenchymal transition in human liver cancer cell lines

Laura Pelletier, Sandra Rebouissou, Danijela Vignjevic, Paulette Bioulac-Sage, Jessica Zucman-Rossi

Open Access Research article

A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells

Asher Castiel, Leonid Visochek, Leonid Mittelman, Françoise Dantzer, Shai Izraeli, Malka Cohen-Armon

Open Access Research article

A phase I trial of PR-104, a pre-prodrug of the bioreductive prodrug PR-104A, given weekly to solid tumour patients

Mark J McKeage, Yongchuan Gu, William R Wilson, Andrew Hill, Karen Amies, Teresa J Melink, Michael B Jameson

Open Access Research article

Gene expression profile of circulating tumor cells in breast cancer by RT-qPCR

Areti Strati, Athina Markou, Cleo Parisi, Eleni Politaki, Dimitris Mavroudis, Vasilis Georgoulias, Evi Lianidou

Open Access Research article

Drug sensitivity patterns of HHV8 carrying body cavity lymphoma cell lines

Rita Ötvös, Henriette Skribek, Lorand L Kis, Annunziata Gloghini, Laszlo Markasz, Emilie Flaberg, Staffan Eksborg, Jozsef Konya, Lajos Gergely, Antonino Carbone, Laszlo Szekely

Open Access Research article

Early metabolic response using FDG PET/CT and molecular phenotypes of breast cancer treated with neoadjuvant chemotherapy

Bhumsuk Keam, Seock-Ah Im, Youngil Koh, Sae-Won Han, Do-Youn Oh, Nariya Cho, Jee Hyun Kim, Wonshik Han, Keon Wook Kang, Woo Kyung Moon, Tae-You Kim, In Ae Park, Dong-Young Noh, June-Key Chung, Yung-Jue Bang

Open Access Study protocol

The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer

Michael Eichbaum, Christine Mayer, Regina Eickhoff, Esther Bischofs, Gerhard Gebauer, Tanja Fehm, Florian Lenz, Hans-Christian Fricke, Erich Solomayer, Nikos Fersis, Marcus Schmidt, Markus Wallwiener, Andreas Schneeweiss, Christof Sohn

Open Access Research article

The combination of gefitinib and RAD001 inhibits growth of HER2 overexpressing breast cancer cells and tumors irrespective of trastuzumab sensitivity

Wieslawa H Dragowska, Sherry A Weppler, Mohammed A Qadir, Ling Yan Wong, Yannick Franssen, Jennifer HE Baker, Anita I Kapanen, Guido JJ Kierkels, Dana Masin, Andrew I Minchinton, Karen A Gelmon, Marcel B Bally

Open Access Case report

Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma

Geir Olav Hjortland, Leonardo A Meza-Zepeda, Klaus Beiske, Anne H Ree, Siri Tveito, Hanne Hoifodt, Per J Bohler, Knut H Hole, Ola Myklebost, Oystein Fodstad, Sigbjorn Smeland, Eivind Hovig

Open Access Research article

MiR-125b promotes proliferation and migration of type II endometrial carcinoma cells through targeting TP53INP1 tumor suppressor in vitro and in vivo

Feizhou Jiang, Te Liu, Yinyan He, Qin Yan, Xiaoyue Chen, Hui Wang, Xiaoping Wan

Open Access Research article

Survival endpoints in colorectal cancer and the effect of second primary other cancer on disease free survival

Helgi Birgisson, Ulrik Wallin, Lars Holmberg, Bengt Glimelius

Open Access Research article

DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study

Bernd Frank, Heiko Müller, Melanie Nicole Weck, Norman Klopp, Thomas Illig, Elke Raum, Hermann Brenner

Open Access Research article

The effect of breast cancer awareness month on internet search activity - a comparison with awareness campaigns for lung and prostate cancer

Ronan W Glynn, John C Kelly, Norma Coffey, Karl J Sweeney, Michael J Kerin

Open Access Research article

High-frequency ultrasound for intraoperative margin assessments in breast conservation surgery: a feasibility study

Timothy E Doyle, Rachel E Factor, Christina L Ellefson, Kristina M Sorensen, Brady J Ambrose, Jeffrey B Goodrich, Vern P Hart, Scott C Jensen, Hemang Patel, Leigh A Neumayer

Open Access Research article

Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68

Maria Libera Ascierto, Andrea Worschech, Zhiya Yu, Sharon Adams, Jennifer Reinboth, Nanhai G Chen, Zoltan Pos, Rahul Roychoudhuri, Giovanni Di Pasquale, Davide Bedognetti, Lorenzo Uccellini, Fabio Rossano, Paolo A Ascierto, David F Stroncek, Nicholas P Restifo, Ena Wang, Aladar A Szalay, Francesco M Marincola

Open Access Research article

Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation

Angela Sedlmaier, Nicolas Wernert, Rainer Gallitzendörfer, Mekky M Abouzied, Volkmar Gieselmann, Sebastian Franken

Open Access Research article

An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition

Lauren MF Merlo, Rachelle E Kosoff, Kristin L Gardiner, Carlo C Maley

Open Access Study protocol

SCOPE1: a randomised phase II/III multicentre clinical trial of definitive chemoradiation, with or without cetuximab, in carcinoma of the oesophagus

Christopher N Hurt, Lisette S Nixon, Gareth O Griffiths, Ruby Al-Mokhtar, Simon Gollins, John N Staffurth, Ceri J Phillips, Jane M Blazeby, Tom D Crosby

Open Access Research article

A study of head and neck cancer treatment and survival among indigenous and non-indigenous people in Queensland, Australia, 1998 to 2004

Suzanne P Moore, Adèle C Green, Gail Garvey, Michael D Coory, Patricia C Valery

Open Access Research article

Elevated urinary levels of urokinase-type plasminogen activator receptor (uPAR) in pancreatic ductal adenocarcinoma identify a clinically high-risk group

Claudio Sorio, Andrea Mafficini, Federico Furlan, Stefano Barbi, Antonio Bonora, Giorgio Brocco, Francesco Blasi, Giorgio Talamini, Claudio Bassi, Aldo Scarpa

Open Access Case report

TP53 mutation p.R337H in gastric cancer tissues of a 12-year-old male child - evidence for chimerism involving a common mutant founder haplotype: case report

Edaise M da Silva, Maria Isabel W Achatz, Ghyslaine Martel-Planche, André L Montagnini, Magali Olivier, Patricia A Prolla, Pierre Hainaut, Fernando A Soares

Open Access Research article

Clinical implication of HLA class I expression in breast cancer

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Open Access Research article

Hepatitis B virus core promoter mutations G1613A and C1653T are significantly associated with hepatocellular carcinoma in genotype C HBV-infected patients

Masashi Tatsukawa, Akinobu Takaki, Hidenori Shiraha, Kazuko Koike, Yoshiaki Iwasaki, Haruhiko Kobashi, Shin-Ichi Fujioka, Kohsaku Sakaguchi, Kazuhide Yamamoto

Open Access Study protocol

Protocol for the OUTREACH trial: a randomised trial comparing delivery of cancer systemic therapy in three different settings - patient's home, GP surgery and hospital day unit

Pippa G Corrie, Margaret Moody, Victoria Wood, Linda Bavister, Toby Prevost, Richard A Parker, Ramon Sabes-Figuera, Paul McCrone, Helen Balsdon, Karen McKinnon, Brendan O'Sullivan, Ray S Tan, Stephen IG Barclay

Open Access Research article

Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosa

Stefan Enroth, Alvaro Rada-Iglesisas, Robin Andersson, Ola Wallerman, Alkwin Wanders, Lars Påhlman, Jan Komorowski, Claes Wadelius

Open Access Research article

Protein and lipid MALDI profiles classify breast cancers according to the intrinsic subtype

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Open Access Research article

The vitamin E analog, alpha-tocopheryloxyacetic acid enhances the anti-tumor activity of trastuzumab against HER2/neu-expressing breast cancer

Tobias Hahn, Deborah J Bradley-Dunlop, Laurence H Hurley, Daniel Von-Hoff, Stephen Gately, Disis L Mary, Hailing Lu, Manuel L Penichet, David G Besselsen, Brook B Cole, Tanisha Meeuwsen, Edwin Walker, Emmanuel T Akporiaye

Open Access Research article

High prevalence of HPV in non-cervical sites of women with abnormal cervical cytology

Robin Crawford, Anne-Laure Grignon, Sarah Kitson, David M Winder, Siolian LR Ball, Katie Vaughan, Margaret A Stanley, Jane C Sterling, Peter KC Goon

Open Access Research article

Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells

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Open Access Research article

Results of combined treatment of anaplastic thyroid carcinoma (ATC)

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Open Access Research article

TNFRSF1B +676 T>G polymorphism predicts survival of non-Small cell lung cancer patients treated with chemoradiotherapy

Xiaoxiang Guan, Zhongxin Liao, Hongxia Ma, Ji Qian, Zhensheng Liu, Xianglin Yuan, Daniel Gomez, Ritsuko Komaki, Li-E Wang, Qingyi Wei

Open Access Research article

Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells

David J Taylor, Christine E Parsons, Haiyong Han, Arul Jayaraman, Kaushal Rege

Open Access Study protocol

Canadian Optically-guided approach for Oral Lesions Surgical (COOLS) trial: study protocol for a randomized controlled trial

Catherine F Poh, J Scott Durham, Penelope M Brasher, Donald W Anderson, Kenneth W Berean, Calum E MacAulay, J Jack Lee, Miriam P Rosin

Open Access Research article

Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors

Wei Zhou, Jingzi Hu, Haimei Tang, Da Wang, Xuefeng Huang, Chao He, Hongbo Zhu

Open Access Research article

Prognostic significance of a systemic inflammatory response in patients receiving first-line palliative chemotherapy for recurred or metastatic gastric cancer

Jun-Eul Hwang, Ha-Na Kim, Dae-Eun Kim, Hyun-Jung Choi, Sung-Hoon Jung, Hyun-Jeong Shim, Woo-Kyun Bae, Eu-Chang Hwang, Sang-Hee Cho, Ik-Joo Chung

Open Access Research article

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines

Kevin Morgan, Colette Meyer, Nicola Miller, Andrew H Sims, Ilgin Cagnan, Dana Faratian, David J Harrison, Robert P Millar, Simon P Langdon

Open Access Research article

The strengths and limitations of routine staging before treatment with abdominal CT in colorectal cancer

Irene Grossmann, Joost M Klaase, Johannes KA Avenarius, Ignace HJT de Hingh, Walter JB Mastboom, Theo Wiggers

Open Access Research article

Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue

Patrizio Castagnola, Davide Malacarne, Paola Scaruffi, Massimo Maffei, Alessandra Donadini, Emanuela Di Nallo, Simona Coco, Gian Paolo Tonini, Monica Pentenero, Sergio Gandolfo, Walter Giaretti

Open Access Research article

How the risk of liver cancer changes after alcohol cessation: A review and meta-analysis of the current literature

Gawain A Heckley, Johan Jarl, Benedict O Asamoah, Ulf G-Gerdtham

Open Access Research article

Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study

Nicolas Samartzis, Patrick Imesch, Konstantin J Dedes, Eleftherios P Samartzis, André Fedier, Daniel Fink, Rosmarie Caduff, Mathias K Fehr

Open Access Research article

Hakai reduces cell-substratum adhesion and increases epithelial cell invasion

Teresa Rodríguez-Rigueiro, Manuel Valladares-Ayerbes, Mar Haz-Conde, Luis A Aparicio, Angélica Figueroa

Open Access Study protocol

Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy

Harald Rief, Alexandra D Jensen, Thomas Bruckner, Klaus Herfarth, Jürgen Debus

Open Access Research article

Pentoxifylline sensitizes human cervical tumor cells to cisplatin-induced apoptosis by suppressing NF-kappa B and decreased cell senescence

Georgina Hernandez-Flores, Pablo C Ortiz-Lazareno, Jose Manuel Lerma-Diaz, Jorge R Dominguez-Rodriguez, Luis F Jave-Suarez, Adriana del C Aguilar-Lemarroy, Ruth de Celis-Carrillo, Susana del Toro-Arreola, Yessica C Castellanos-Esparza, Alejandro Bravo-Cuellar

Open Access Research article

Role and expression of FRS2 and FRS3 in prostate cancer

Tania Valencia, Ajay Joseph, Naveen Kachroo, Steve Darby, Susan Meakin, Vincent J Gnanapragasam

Open Access Case report

Paraneoplastic syndrome mimicking adult-onset Still's disease caused by advanced lung cancer: a case report

Ning Wu, Qiang Li, Chang-Xin Gu, Toqeer Ahmed, Xiao-Peng Yao

Open Access Research article

Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action

Chandeshwari Chilampalli, Ruth Guillermo, Xiaoying Zhang, Radhey S Kaushik, Alan Young, David Zeman, Michael B Hildreth, Hesham Fahmy, Chandradhar Dwivedi

Open Access Research article

Activation of the human immune system by chemotherapeutic or targeted agents combined with the oncolytic parvovirus H-1

Markus Moehler, Maike Sieben, Susanne Roth, Franziska Springsguth, Barbara Leuchs, Maja Zeidler, Christiane Dinsart, Jean Rommelaere, Peter R Galle

Open Access Research article

Pharmacogenetic profiling and cetuximab outcome in patients with advanced colorectal cancer

Laetitia Dahan, Emmanuelle Norguet, Marie-Christine Etienne-Grimaldi, Jean-Louis Formento, Mohamed Gasmi, Isabelle Nanni, Jean Gaudart, Stéphane Garcia, L'Houcine Ouafik, Jean-François Seitz, Gérard Milano

Open Access Research article

A cost-effectiveness analysis of a preventive exercise program for patients with advanced head and neck cancer treated with concomitant chemo-radiotherapy

Valesca P Retèl, Lisette van der Molen, Frans JM Hilgers, Coen RN Rasch, Annemiek AAMHJ L'Ortye, Lotte MG Steuten, Wim H van Harten

Open Access Research article

Clinicopathologic and gene expression parameters predict liver cancer prognosis

Ke Hao, John Lamb, Chunsheng Zhang, Tao Xie, Kai Wang, Bin Zhang, Eugene Chudin, Nikki P Lee, Mao Mao, Hua Zhong, Danielle Greenawalt, Mark D Ferguson, Irene O Ng, Pak C Sham, Ronnie T Poon, Cliona Molony, Eric E Schadt, Hongyue Dai, John M Luk

Open Access Erratum

Erratum to:Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas

Yosuke Hashimoto, Marek Skacel, Ian C Lavery, Abir L Mukherjee, Graham Casey, Josephine C Adams

Open Access Research article

Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line

Gobind Singh, Leticia Odriozola, Hong Guan, Colin R Kennedy, Andrew M Chan

Open Access Research article

Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells

Jeffery D Eskew, Takrima Sadikot, Pedro Morales, Alicia Duren, Irene Dunwiddie, Megan Swink, Xiaoying Zhang, Stacey Hembruff, Alison Donnelly, Roger A Rajewski, Brian SJ Blagg, Jacob R Manjarrez, Robert L Matts, Jeffrey M Holzbeierlein, George A Vielhauer

Open Access Research article

YY1 overexpression is associated with poor prognosis and metastasis-free survival in patients suffering osteosarcoma

Filomena de Nigris, Licciana Zanella, Francesco Cacciatore, Anna De Chiara, Flavio Fazioli, Gennaro Chiappetta, Gaetano Apice, Teresa Infante, Mario Monaco, Raffaele Rossiello, Gaetano De Rosa, Marco Alberghini, Claudio Napoli

Open Access Research article

STAT3 activation in monocytes accelerates liver cancer progression

Wen-Yong Wu, Jun Li, Zheng-Sheng Wu, Chang-Le Zhang, Xiang-Ling Meng

Open Access Research article

The usefulness and feasibility of a screening instrument to identify psychosocial problems in patients receiving curative radiotherapy: a process evaluation

Anna PBM Braeken, Gertrudis IJM Kempen, Daniëlle Eekers, Francis CJM van Gils, Ruud MA Houben, Lilian Lechner

Open Access Review

Targeting hypoxic tumour cells to overcome metastasis

Kevin L Bennewith, Shoukat Dedhar

Open Access Research article

A phase II study evaluating neo-/adjuvant EIA chemotherapy, surgical resection and radiotherapy in high-risk soft tissue sarcoma

Thomas Schmitt, Burkhard Lehner, Bernd Kasper, Marc Bischof, Falk Roeder, Sascha Dietrich, Antonia Dimitrakopoulou-Strauss, Ludwig G Strauss, Gunhild Mechtersheimer, Patrick Wuchter, Anthony D Ho, Gerlinde Egerer

Open Access Research article

The HOPE fixation technique - a promising alternative to common prostate cancer biobanking approaches

Martin Braun, Roopika Menon, Pavel Nikolov, Robert Kirsten, Karen Petersen, David Schilling, Christina Schott, Sibylle Gündisch, Falko Fend, Karl-Friedrich Becker, Sven Perner

Open Access Research article

Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules

Elena Kupert, Marshall Anderson, Yin Liu, Paul Succop, Linda Levin, Jiang Wang, Kathryn Wikenheiser-brokamp, Pingping Chen, Susan M Pinney, Trudy Macdonald, Zhongyun Dong, Sandra Starnes, Shan Lu

Open Access Research article

Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

Birgit Luber, Joëlle Deplazes, Gisela Keller, Axel Walch, Sandra Rauser, Martin Eichmann, Rupert Langer, Heinz Höfler, Susanna Hegewisch-Becker, Gunnar Folprecht, Ewald Wöll, Thomas Decker, Esther Endlicher, Sylvie Lorenzen, Falko Fend, Christian Peschel, Florian Lordick

Open Access Research article

Adaptation to statins restricts human tumour growth in Nude mice

Julie Follet, Lionel Rémy, Vincent Hesry, Brigitte Simon, Danièle Gillet, Pierrick Auvray, Laurent Corcos, Catherine Le Jossic-Corcos

Open Access Study protocol

Fast track multi-discipline treatment (FTMDT trial) versus conventional treatment in colorectal cancer--the design of a prospective randomized controlled study

Jiao-Jiao Zhou, Jun Li, Xiao-Jiang Ying, Yong-Mao Song, Rong Chen, Gang Chen, Min Yan, Ke-Feng Ding

Open Access Review

Current views on the role of Notch signaling and the pathogenesis of human leukemia

Joanna Pancewicz, Christophe Nicot

Open Access Commentary

Ten years of progress in radiation oncology

Dirk Vordermark

Open Access Research article

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

Jan C Brase, Marc Johannes, Heiko Mannsperger, Maria Fälth, Jennifer Metzger, Lukasz A Kacprzyk, Tatjana Andrasiuk, Stephan Gade, Michael Meister, Hüseyin Sirma, Guido Sauter, Ronald Simon, Thorsten Schlomm, Tim Beißbarth, Ulrike Korf, Ruprecht Kuner, Holger Sültmann

Open Access Research article

Regulation of hTERT by BCR-ABL at multiple levels in K562 cells

Juin Hsien Chai, Yong Zhang, Wei Han Tan, Wee Joo Chng, Baojie Li, Xueying Wang

Open Access Research article

The influence of cardiovascular morbidity on the prognosis in prostate cancer. Experience from a 12-year nationwide Danish population-based cohort study

Christina G Jespersen, Mette Nørgaard, Truls E Bjerklund Johansen, Mette Søgaard, Michael Borre

Open Access Research article

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation

Jessica ES Bohonowych, Shuping Peng, Udhayakumar Gopal, Michael W Hance, Shane B Wing, Kelley M Argraves, Karen Lundgren, Jennifer S Isaacs

Open Access Research article

Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide

Tao Yan, Kai Ove Skaftnesmo, Lina Leiss, Linda Sleire, Jian Wang, Xingang Li, Per Øyvind Enger

Open Access Review

Micro-RNAs as diagnostic or prognostic markers in human epithelial malignancies

Angela Hui, Christine How, Emma Ito, Fei-Fei Liu

Open Access Research article

The association of APE1 −656T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies

Bin Zhou, Hailin Shan, Ying Su, Kai Xia, Xiaxia Shao, Weidong Mao, Qing Shao

Open Access Research article

RETRACTED ARTICLE: Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells

Bin Wu, Ji Li, Damao Huang, Weiwei Wang, Yu Chen, Youxiang Liao, Xiaowei Tang, Hongfu Xie, Faqing Tang

Open Access Research article

Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study

Fu-Hsiung Su, Shih-Ni Chang, Pei-Chun Chen, Fung-Chang Sung, Chien-Tien Su, Chih-Ching Yeh

Open Access Research article

Chemotherapeutic errors in hospitalised cancer patients: attributable damage and extra costs

Florence Ranchon, Gilles Salles, Hans-Martin Späth, Vérane Schwiertz, Nicolas Vantard, Stéphanie Parat, Florence Broussais, Benoît You, Sophie Tartas, Pierre Jean Souquet, Claude Dussart, Claire Falandry, Emilie Henin, Gilles Freyer, Catherine Rioufol

Open Access Research article

Ki67, chemotherapy response, and prognosis in breast cancer patients receiving neoadjuvant treatment

Peter A Fasching, Katharina Heusinger, Lothar Haeberle, Melitta Niklos, Alexander Hein, Christian M Bayer, Claudia Rauh, Ruediger Schulz-Wendtland, Mayada R Bani, Michael Schrauder, Laura Kahmann, Michael P Lux, Johanna D Strehl, Arndt Hartmann, Arno Dimmler, Matthias W Beckmann, David L Wachter

Open Access Research article

Expression of delta-catenin is associated with progression of human astrocytoma

Wang MingHao, Dong Qianze, Zhang Di, Wang YunJie

Open Access Research article

Prospective study of physical activity and risk of squamous cell carcinoma of the skin

Petra H Lahmann, Anne Russell, Adèle C Green

Open Access Review

The breast cancer genome - a key for better oncology

Hans Kristian Moen Vollan, Carlos Caldas

Open Access Study protocol

Efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases: a randomized controlled trial

Daniel A Galvão, Dennis R Taaffe, Prue Cormie, Nigel Spry, Suzanne K Chambers, Carolyn Peddle-McIntyre, Michael Baker, James Denham, David Joseph, Geoff Groom, Robert U Newton

Open Access Research article

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

Jens Neumann, Fiorina Bahr, David Horst, Lydia Kriegl, Jutta Engel, Raquel Mejías-Luque, Markus Gerhard, Thomas Kirchner, Andreas Jung

Open Access Research article

Inhibition of N-linked glycosylation impairs ALK phosphorylation and disrupts pro-survival signaling in neuroblastoma cell lines

Federica Del Grosso, Marilena De Mariano, Lorena Passoni, Roberto Luksch, Gian Paolo Tonini, Luca Longo

Open Access Research article

Human cancer cells express Slug-based epithelial-mesenchymal transition gene expression signature obtained in vivo

Dimitris Anastassiou, Viktoria Rumjantseva, Weiyi Cheng, Jianzhong Huang, Peter D Canoll, Darrell J Yamashiro, Jessica J Kandel

Open Access Editorial

A decade of progress in cancer research

Christna Chap, Jigisha Patel

Open Access Research article

Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon

Agnieszka Anna Rawłuszko, Karolina Horbacka, Piotr Krokowicz, Paweł Piotr Jagodziński

Open Access Research article

Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma

Keiko Matsuura, Chisato Nakada, Mizuho Mashio, Takahiro Narimatsu, Taichiro Yoshimoto, Masato Tanigawa, Yoshiyuki Tsukamoto, Naoki Hijiya, Ichiro Takeuchi, Takeo Nomura, Fuminori Sato, Hiromitsu Mimata, Masao Seto, Masatsugu Moriyama

Open Access Research article

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

Sucheta Telang, Mary Ann Rasku, Amy L Clem, Karen Carter, Alden C Klarer, Wesley R Badger, Rebecca A Milam, Shesh N Rai, Jianmin Pan, Hana Gragg, Brian F Clem, Kelly M McMasters, Donald M Miller, Jason Chesney

Open Access Research article

Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

Hani Kim, Lisa C Gillis, Jordan D Jarvis, Stuart Yang, Kai Huang, Sandy Der, Dwayne L Barber

Open Access Research article

Identification of α(1,6)fucosylated proteins differentially expressed in human colorectal cancer

Laura Muinelo-Romay, Susana Villar-Portela, Elisa Cuevas, Emilio Gil-Martín, Almudena Fernández-Briera

Open Access Research article

Clinical features and prognostic factors in patients with bone metastases from hepatocellular carcinoma after liver transplantation

Jian He, Zhao-Chong Zeng, Jia Fan, Jian Zhou, Jing Sun, Bing Chen, Ping Yang, Bin-Liang Wang, Bo-Heng Zhang, Jian-Ying Zhang

Open Access Study protocol

Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

Charlotte M Huijts, Saskia J Santegoets, Alfons J van den Eertwegh, Laura S Pijpers, John B Haanen, Tanja D de Gruijl, Henk M Verheul, Hans J van der Vliet

Open Access Research article

Induction of B-cell lymphoma by UVB Radiation in p53 Haploinsufficient Mice

Nahum Puebla-Osorio, Yasuko Miyahara, Sreevidya Coimbatore, Alberto Y Limón-Flores, Nasser Kazimi, Stephen E Ullrich, Chengming Zhu

Open Access Research article

Determinants of patient satisfaction in ambulatory oncology: a cross sectional study based on the OUT-PATSAT35 questionnaire

Nguyen Thanh Vân France, Jean-François Bosset, Alain Monnier, Jacqueline Fournier, Valérie Perrin, Cédric Baumann, Anne Brédart, Mariette Mercier

Open Access Research article

Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis

Satoshi Watanabe, Junta Tanaka, Takeshi Ota, Rie Kondo, Hiroshi Tanaka, Hiroshi Kagamu, Kosuke Ichikawa, Jun Koshio, Junko Baba, Takao Miyabayashi, Ichiei Narita, Hirohisa Yoshizawa

Open Access Research article

The impact of audit and feedback on nodal harvest in colorectal cancer

Geoffrey A Porter, Robin Urquhart, Jingyu Bu, Paul Johnson, Eva Grunfeld

Open Access Research article

Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis

Yutaka Nakanishi, Hidenori Shiraha, Shin-ichi Nishina, Shigetomi Tanaka, Minoru Matsubara, Shigeru Horiguchi, Masaya Iwamuro, Nobuyuki Takaoka, Masayuki Uemura, Kenji Kuwaki, Hiroaki Hagihara, Junichi Toshimori, Hideki Ohnishi, Akinobu Takaki, Shinichiro Nakamura, Yoshiyuki Kobayashi, Kazuhiro Nouso, Takahito Yagi, Kazuhide Yamamoto

Open Access Research article

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

Carina Roth, Klaus Pantel, Volkmar Müller, Brigitte Rack, Sabine Kasimir-Bauer, Wolfgang Janni, Heidi Schwarzenbach

Open Access Research article

Factors influencing general practitioners in the referral of elderly cancer patients

Fleur Delva, Emilie Marien, Marianne Fonck, Muriel Rainfray, Jean-Louis Demeaux, Philippe Moreaud, Pierre Soubeyran, Annie J Sasco, Simone Mathoulin-Pélissier

Open Access Study protocol

Behavioral and psychosocial effects of rapid genetic counseling and testing in newly diagnosed breast cancer patients: Design of a multicenter randomized clinical trial

Marijke R Wevers, Margreet GEM Ausems, Senno Verhoef, Eveline MA Bleiker, Daniela EE Hahn, Frans BL Hogervorst, Rob B van der Luijt, Heiddis B Valdimarsdottir, Richard van Hillegersberg, Emiel JTh Rutgers, Neil K Aaronson

Open Access Research article

Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

Sarice R Boston, Rahul Deshmukh, Scott Strome, U Deva Priyakumar, Alexander D MacKerell Jr, Paul Shapiro

Open Access Research article

Pattern of lateral neck metastases in N0 papillary thyroid carcinoma

Vincent Patron, Cécile Bedfert, Guy Le Clech, Karine Aubry, Franck Jegoux

Open Access Research article

A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation

Jessica Castro, Marc Ribó, Susanna Navarro, Maria Victòria Nogués, Maria Vilanova, Antoni Benito

Open Access Research article

Support vector machine model for diagnosis of lymph node metastasis in gastric cancer with multidetector computed tomography: a preliminary study

Xiao-Peng Zhang, Zhi-Long Wang, Lei Tang, Ying-Shi Sun, Kun Cao, Yun Gao

Open Access Research article

ABI3 ectopic expression reduces in vitro and in vivocell growth properties while inducing senescence

Flavia RM Latini, Jefferson P Hemerly, Beatriz CG Freitas, Gisele Oler, Gregory J Riggins, Janete M Cerutti

Open Access Research article

Carbonic anhydrase IX in tumor tissue and sera of patients with primary cervical cancer

Linn Woelber, Kerstin Kress, Jan F Kersten, Matthias Choschzick, Ergin Kilic, Uwe Herwig, Christoph Lindner, Joerg Schwarz, Fritz Jaenicke, Sven Mahner, Karin Milde-Langosch, Volkmar Mueller, Maike Ihnen

Open Access Erratum

Erratum to: triple-negative, basal-like, and quintuple-negative breast cancers: better prediction model for survival

Yoon-La Choi, Ensel Oh, Sarah Park, Yeonju Kim, Yeon-Hee Park, Kyug Song, Eun Yoon Cho, Yun-Chul Hong, Jong Sun Choi, Jeong Eon Lee, Jung Han Kim, Seok Jin Nam, Young-Hyuck Lim, Jung-Hyun Yang, Young Kee Shin

Open Access Research article

Expression profile of the N-myc Downstream Regulated Gene 2 (NDRG2) in human cancers with focus on breast cancer

Anders Lorentzen, Rikke H Lewinsky, Jette Bornholdt, Lotte K Vogel, Cathy Mitchelmore

Open Access Research article

Smac mimetic-derived augmentation of chemotherapeutic response in experimental pancreatic cancer

Niranjan Awasthi, Amanda Kirane, Margaret A Schwarz, Jason E Toombs, Rolf A Brekken, Roderich E Schwarz

Open Access Research article

Can Bcl-XL expression predict the radio sensitivity of Bilharzial-related squamous bladder carcinoma? a prospective comparative study

Ahmad M Abdel Raheem, Diaa A Hameed, Ehab O ElGanainy, Eman Mosad, Mostafa E Abdelwanis, Nermen A Kamel, Hisham M Hammouda, Mohammad A Abdelaziz, Khaled Hemeyda

Open Access Research article

Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells

Luisa Accardi, Maria Gabriella Donà, Anna M Mileo, Marco G Paggi, Antonio Federico, Paola Torreri, Tamara C Petrucci, Rosita Accardi, David Pim, Massimo Tommasino, Lawrence Banks, Barbara Chirullo, Colomba Giorgi

Open Access Research article

A novel insight of sentinel lymph node concept based on 1-3 positive nodes in patients with pT1-2 gastric cancer

Baojun Huang, Zhenning Wang, Zhe Sun, Bo Zhao, Huimian Xu

Open Access Research article

Classical homeopathy in the treatment of cancer patients - a prospective observational study of two independent cohorts

Matthias Rostock, Johannes Naumann, Corina Guethlin, Lars Guenther, Hans H Bartsch, Harald Walach

Open Access Research article

Long term outcome of high-risk neuroblastoma patients after immunotherapy with antibody ch14.18 or oral metronomic chemotherapy

Thorsten Simon, Barbara Hero, Andreas Faldum, Rupert Handgretinger, Martin Schrappe, Thomas Klingebiel, Frank Berthold

Open Access Research article

Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel

Chun-Fang Zou, Luoqi Jia, Hongyan Jin, Ming Yao, Naiqing Zhao, Jin Huan, Zhen Lu, Robert C Bast Jr, Youji Feng, Yinhua Yu

Open Access Case report

Intracranial metastasis from primary transitional cell carcinoma of female urethra: case report & review of the literature

Kyung-Sub Moon, Shin Jung, Kyung-Hwa Lee, Eu Chang Hwang, In-Young Kim

Open Access Research article

Bim and Mcl-1 exert key roles in regulating JAK2V617Fcell survival

Joëlle Rubert, Zhiyan Qian, Rita Andraos, Daniel A Guthy, Thomas Radimerski

Open Access Research article

Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

Michel S Beausoleil, Erika B Schulze, David Goodale, Carl O Postenka, Alison L Allan

Open Access Research article

Fish consumption and the risk of gastric cancer: systematic review and meta-analysis

Shengjun Wu, Jie Liang, Lei Zhang, Xia Zhu, Xufeng Liu, Danmin Miao

Open Access Research article

Breast cancer and human papillomavirus infection: No evidence of HPV etiology of breast cancer in Indian women

Suresh Hedau, Umesh Kumar, Showket Hussain, Shirish Shukla, Shailja Pande, Neeraj Jain, Abhishek Tyagi, Trivikram Deshpande, Dilafroze Bhat, Mohammad Muzaffar Mir, Sekhar Chakraborty, Y Mohan Singh, Rakesh Kumar, Kumaravel Somasundaram, Alok C Bharti, Bhudev C Das

Open Access Research article

Antiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography

Xiao-Dong Zhu, Ju-Bo Zhang, Pei-Li Fan, Yu-Quan Xiong, Peng-Yuan Zhuang, Wei Zhang, Hua-Xiang Xu, Dong-Mei Gao, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang, Hong Ding, Hui-Chuan Sun

Open Access Research article

Incidence of bone metastases and skeletal-related events in breast cancer patients: A population-based cohort study in Denmark

Annette Ø Jensen, Jacob B Jacobsen, Mette Nørgaard, Mellissa Yong, Jon P Fryzek, Henrik T Sørensen

Open Access Research article

Identification and Regulation of c-Myb Target Genes in MCF-7 Cells

Anita M Quintana, Fan Liu, John P O'Rourke, Scott A Ness

Open Access Research article

Tumor-suppressor activity of RRIG1 in breast cancer

Guihong Zhang, Abenaa Brewster, Baoxiang Guan, Zhen Fan, Powel H Brown, Xiao-Chun Xu

Open Access Research article

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

Amanda Tivnan, Lorraine Tracey, Patrick G Buckley, Leah C Alcock, Andrew M Davidoff, Raymond L Stallings

Open Access Research article

Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Chen-Hsi Hsieh, Ying-Shiung Kuo, Li-Jen Liao, Kawang-Yu Hu, Shih-Chiang Lin, Le-Jung Wu, Yu-Chin Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Shoei Long Lin, Chun-Yi Chen, Chien-An Chen, Pei-Wei Shueng

Open Access Research article

FLT3 mutations in canine acute lymphocytic leukemia

Steven E Suter, George W Small, Eric L Seiser, Rachael Thomas, Matthew Breen, Kristy L Richards

Open Access Research article

In vivo imaging of pancreatic tumours and liver metastases using 7 Tesla MRI in a murine orthotopic pancreatic cancer model and a liver metastases model

Ivo L Partecke, André Kaeding, Matthias Sendler, Nele Albers, Jens-P Kühn, Sven Speerforck, Sebastian Roese, Florian Seubert, Stephan Diedrich, Sandra Kuehn, Ulrich F Weiss, Julia Mayerle, Markus M Lerch, Stefan Hadlich, Norbert Hosten, Claus-D Heidecke, Ralf Puls, Wolfram von Bernstorff

Open Access Research article

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

Claudia Lengerke, Tanja Fehm, Ralf Kurth, Hans Neubauer, Veit Scheble, Friederike Müller, Friederike Schneider, Karen Petersen, Diethelm Wallwiener, Lothar Kanz, Falko Fend, Sven Perner, Petra M Bareiss, Annette Staebler

Open Access Research article

Oncolytic targeting of androgen-sensitive prostate tumor by the respiratory syncytial virus (RSV): consequences of deficient interferon-dependent antiviral defense

Ibtissam Echchgadda, Te-Hung Chang, Ahmed Sabbah, Imad Bakri, Yuji Ikeno, Gene B Hubbard, Bandana Chatterjee, Santanu Bose

Open Access Research article

Mechanisms of confluence-dependent expression of CD26 in colon cancer cell lines

Masako Abe, Pamela A Havre, Yasuyo Urasaki, Kei Ohnuma, Chikao Morimoto, Long H Dang, Nam H Dang

Open Access Research article

A novel tumor suppressor gene ECRG4 interacts directly with TMPRSS11A (ECRG1) to inhibit cancer cell growth in esophageal carcinoma

Lin-wei Li, Yuan-yuan Li, Xiao-yan Li, Chun-peng Zhang, Yun Zhou, Shih-Hsin Lu

Open Access Research article

Serum antibodies against genitourinary infectious agents in prostate cancer and benign prostate hyperplasia patients: a case-control study

Jan Hrbacek, Michael Urban, Eva Hamsikova, Ruth Tachezy, Vaclav Eis, Marek Brabec, Jiri Heracek

Open Access Research article

Neoadjuvant imatinib in patients with locally advanced non metastatic GIST in the prospective BFR14 trial

Aurore Blesius, Philippe A Cassier, François Bertucci, Jerome Fayette, Isabelle Ray-Coquard, Binh Bui, Antoine Adenis, Maria Rios, Didier Cupissol, David Pérol, Jean-Yves Blay, Axel Le Cesne

Open Access Research article

c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients

André O von Bueren, Christoph Oehler, Tarek Shalaby, Katja von Hoff, Martin Pruschy, Burkhardt Seifert, Nicolas U Gerber, Monika Warmuth-Metz, Duncan Stearns, Charles G Eberhart, Rolf D Kortmann, Stefan Rutkowski, Michael A Grotzer

Open Access Research article

Effects on quality of life of weekly docetaxel-based chemotherapy in patients with locally advanced or metastatic breast cancer: results of a single-centre randomized phase 3 trial

Francesco Nuzzo, Alessandro Morabito, Adriano Gravina, Francesca Di Rella, Gabriella Landi, Carmen Pacilio, Vincenzo Labonia, Emanuela Rossi, Ermelinda De Maio, Maria Carmela Piccirillo, Giuseppe D'Aiuto, Renato Thomas, Massimo Rinaldo, Gerardo Botti, Maurizio Di Bonito, Massimo Di Maio, Ciro Gallo, Francesco Perrone, Andrea de Matteis

Open Access Research article

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

María S Domínguez-Sánchez, Carmen Sáez, Miguel A Japón, Andrés Aguilera, Rosa Luna

Open Access Research article

Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma

Min-A Seol, In-Sun Chu, Mi-Jin Lee, Goung-Ran Yu, Xiang-Dan Cui, Baik-Hwan Cho, Eun-Kyung Ahn, Sun-Hee Leem, In-Hee Kim, Dae-Ghon Kim

Open Access Research article

Identification and validation of genes involved in cervical tumourigenesis

Thangarajan Rajkumar, Kesavan Sabitha, Neelakantan Vijayalakshmi, Sundersingh Shirley, Mayil Vahanan Bose, Gopisetty Gopal, Ganesharaja Selvaluxmy

Open Access Research article

Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

Wataru Habano, Toshie Gamo, Jun Terashima, Tamotsu Sugai, Koki Otsuka, Go Wakabayashi, Shogo Ozawa

Open Access Research article

Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells

Yi-Yang Hu, Min-Hua Zheng, Gang Cheng, Liang Li, Liang Liang, Fang Gao, Ya-Ning Wei, Luo-An Fu, Hua Han

Open Access Research article

Overexpression of GPR39 contributes to malignant development of human esophageal squamous cell carcinoma

Fajun Xie, Haibo Liu, Ying-Hui Zhu, Yan-Ru Qin, Yongdong Dai, Tingting Zeng, Leilei Chen, Changjun Nie, Hong Tang, Yan Li, Li Fu, Xin-Yuan Guan

Open Access Research article

Diet folate, DNA methylation and genetic polymorphisms of MTHFRC677T in association with the prognosis of esophageal squamous cell carcinoma

Cheng Lu, Hui Xie, Fengliang Wang, Hongbing Shen, Jianming Wang

Open Access Study protocol

Manual lymphatic drainage therapy in patients with breast cancer related lymphoedema

Marta López Martín, Miguel A Hernández, Cristina Avendaño, Francisco Rodríguez, Helena Martínez

Open Access Research article

Validation of prognostic scores for survival in cancer patients beyond first-line therapy

Olivier Trédan, Isabelle Ray-Coquard, Gisèle Chvetzoff, Paul Rebattu, Agathe Bajard, Sylvie Chabaud, David Pérol, Chadi Saba, Florent Quiblier, Jean-Yves Blay, Thomas Bachelot

Open Access Research article

Coffee consumption and risk of cancers: a meta-analysis of cohort studies

Xiaofeng Yu, Zhijun Bao, Jian Zou, Jie Dong

Open Access Research article

Resveratrol protects leukemic cells against cytotoxicity induced by proteasome inhibitors via induction of FOXO1 and p27Kip1

Xiao-Fang Niu, Bao-Qin Liu, Zhen-Xian Du, Yan-Yan Gao, Chao Li, Ning Li, Yifu Guan, Hua-Qin Wang

Open Access Research article

CXCL12 expression by healthy and malignant ovarian epithelial cells

Véronique Machelon, Françoise Gaudin, Sophie Camilleri-Broët, Salam Nasreddine, Laurence Bouchet-Delbos, Eric Pujade-Lauraine, Jerôme Alexandre, Laurence Gladieff, Fernando Arenzana-Seisdedos, Dominique Emilie, Sophie Prévot, Philippe Broët, Karl Balabanian

Open Access Research article

Phase II study of preoperative radiation plus concurrent daily tegafur-uracil (UFT) with leucovorin for locally advanced rectal cancer

Patrice Cellier, Bernard Leduc, Laurent Martin, Brigitte Vié, Christian Chevelle, Véronique Vendrely, Augustin Salemkour, Christian Carrie, Gilles Calais, Pascal Burtin, Loïc Campion, Michèle Boisdron-Celle, Alain Morel, Virginie Berger, Erick Gamelin

Open Access Research article

Correlation of SHOX2 Gene Amplification and DNA Methylation in Lung Cancer Tumors

Katja U Schneider, Dimo Dietrich, Michael Fleischhacker, Gunda Leschber, Johannes Merk, Frank Schäper, Henk R Stapert, Erik R Vossenaar, Sabine Weickmann, Volker Liebenberg, Christoph Kneip, Anke Seegebarth, Fikret Erdogan, Gudrun Rappold, Bernd Schmidt

Open Access Research article

Impact of PINCH expression on survival in colorectal cancer patients

Jasmine Lööf, Johan Rosell, Charlotte Bratthäll, Siv Doré, Hans Starkhammar, Hong Zhang, Xiao-Feng Sun

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