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BMC Cancer

Ausgabe 1/2012

Inhalt (627 Artikel)

Open Access Research article

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast

Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino

Open Access Research article

Volumetric and MGMT parameters in glioblastoma patients: Survival analysis

Georgios Iliadis, Vassiliki Kotoula, Athanasios Chatzisotiriou, Despina Televantou, Anastasia G Eleftheraki, Sofia Lambaki, Despina Misailidou, Panagiotis Selviaridis, George Fountzilas

Open Access Research article

Cholesterol and the risk of grade-specific prostate cancer incidence: evidence from two large prospective cohort studies with up to 37 years' follow up

Kashif Shafique, Philip McLoone, Khaver Qureshi, Hing Leung, Carole Hart, David S Morrison

Open Access Research article

Incidence and survival of oesophageal and gastric cancer in England between 1998 and 2007, a population-based study

Victoria H Coupland, William Allum, Jane M Blazeby, Michael A Mendall, Richard H Hardwick, Karen M Linklater, Henrik Møller, Elizabeth A Davies

Open Access Research article

Gene expression in tumor cells and stroma in dsRed 4T1 tumors in eGFP-expressing mice with and without enhanced oxygenation

Ingrid Moen, Charlotte Jevne, Jian Wang, Karl-Henning Kalland, Martha Chekenya, Lars A Akslen, Linda Sleire, Per Ø Enger, Rolf K Reed, Anne M Øyan, Linda EB Stuhr

Open Access Research article

Induction of cell proliferation and survival genes by estradiol-repressed microRNAs in breast cancer cells

Xinfeng Yu, Xuemei Zhang, Ishwori B Dhakal, Marjorie Beggs, Susan Kadlubar, Dali Luo

Open Access Research article

"A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies"

Carolyn G Marsden, Mary Jo Wright, Latonya Carrier, Krzysztof Moroz, Radhika Pochampally, Brian G Rowan

Open Access Research article

TGF-β1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1/2 in highly invasive breast cancer cells

Luciana R Gomes, Letícia F Terra, Rosângela AM Wailemann, Leticia Labriola, Mari C Sogayar

Open Access Research article

Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer

Isabelle Dufau, Céline Frongia, Flavie Sicard, Laure Dedieu, Pierre Cordelier, Frédéric Ausseil, Bernard Ducommun, Annie Valette

Open Access Research article

A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients

Alois H Lang, Simone Geller-Rhomberg, Thomas Winder, Nicole Stark, Klaus Gasser, Bernd Hartmann, Bertram Kohler, Ina Grizelj, Heinz Drexel, Axel Muendlein

Open Access Research article

Predictive and prognostic value of circulating nucleosomes and serum biomarkers in patients with metastasized colorectal cancer undergoing Selective Internal Radiation Therapy

Yvonne Nadine Fahmueller, Dorothea Nagel, Ralf-Thorsten Hoffmann, Klaus Tatsch, Tobias Jakobs, Petra Stieber, Stefan Holdenrieder

Open Access Research article

Contribution of cell blocks obtained through endobronchial ultrasound-guided transbronchial needle aspiration to the diagnosis of lung cancer

José Sanz-Santos, Pere Serra, Felipe Andreo, Maria Llatjós, Eva Castellà, Eduard Monsó

Open Access Research article

Biomarkers for antitumor activity of bevacizumab in gastric cancer models

Yoriko Yamashita-Kashima, Kaori Fujimoto-Ouchi, Keigo Yorozu, Mitsue Kurasawa, Mieko Yanagisawa, Hideyuki Yasuno, Kazushige Mori

Open Access Research article

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

J Sven D Mieog, Esther M de Kruijf, Esther Bastiaannet, Peter JK Kuppen, Anita Sajet, Anton JM de Craen, Vincent THBM Smit, Cornelis JH van de Velde, Gerrit-Jan Liefers

Open Access Research article

Expression and clinical significance of extracellular matrix protein 1 and vascular endothelial growth factor-C in lymphatic metastasis of human breast cancer

Qiu-Wan Wu, Hong-Qiang She, Jing Liang, Yu-Fan Huang, Qing-Mo Yang, Qiao-Lu Yang, Zhi-Ming Zhang

Open Access Research article

Transarterial chemoembolization plus or minus intravenous bevacizumab in the treatment of hepatocellular cancer: A pilot study

Carolyn D Britten, Antoinette S Gomes, Zev A Wainberg, David Elashoff, Rafael Amado, Yan Xin, Ronald W Busuttil, Dennis J Slamon, Richard S Finn

Open Access Research article

Obesity, body composition, and prostate cancer

Jay H Fowke, Saundra S Motley, Raoul S Concepcion, David F Penson, Daniel A Barocas

Open Access Research article

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

Esther M de Kruijf, Anita Sajet, Johanna GH van Nes, Hein Putter, Vincent THBM Smit, Robert A Eagle, Insiya Jafferji, John Trowsdale, Gerrit Jan Liefers, Cornelis JH van de Velde, Peter JK Kuppen

Open Access Research article

Inhibition of STAT3 signaling and induction of SHP1 mediate antiangiogenic and antitumor activities of ergosterol peroxide in U266 multiple myeloma cells

Yun-Hee Rhee, Soo-Jin Jeong, Hyo-Jeong Lee, Hyo-Jung Lee, Wonil Koh, Ji Hoon Jung, Sun-Hee Kim, Kim Sung-Hoon

Open Access Case report

Axillary node metastasis from differentiated thyroid carcinoma with hürthle and signet ring cell differentiation. A case of disseminated thyroid cancer with peculiar histologic findings

Maria Grazia Chiofalo, Nunzia Simona Losito, Franco Fulciniti, Sergio Venanzio Setola, Antonio Tommaselli, Ugo Marone, Maria Luisa Di Cecilia, Luciano Pezzullo

Open Access Research article

Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method

Benjamin Tournier, Caroline Chapusot, Emilie Courcet, Laurent Martin, Côme Lepage, Jean Faivre, Françoise Piard

Open Access Research article

Anti-apoptotic gene transcription signature of salivary gland neoplasms

Carolina Cavaliéri Gomes, Vanessa Fátima Bernardes, Marina Gonçalves Diniz, Luiz De Marco, Ricardo Santiago Gomez

Open Access Research article

Second-line Treatment of Stage III/IV Non-Small-Cell Lung Cancer (NSCLC) with pemetrexed in routine clinical practice: Evaluation of performance status and health-related quality of life

Wolfgang Schuette, Hans Tesch, Hartwig Büttner, Thomas Krause, Victoria Soldatenkova, Clemens Stoffregen

Open Access Research article

Risk factors associated with fatal pulmonary hemorrhage in locally advanced non-small cell lung cancer treated with chemoradiotherapy

Masami Ito, Seiji Niho, Keiji Nihei, Kiyotaka Yoh, Hironobu Ohmatsu, Yuichiro Ohe

Open Access Research article

Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review

Susanne Hartwig, Stina Syrjänen, Géraldine Dominiak-Felden, Maria Brotons, Xavier Castellsagué

Open Access Research article

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

Seiki Miura, Noboru Mitsuhashi, Hiroaki Shimizu, Fumio Kimura, Hiroyuki Yoshidome, Masayuki Otsuka, Atsushi Kato, Takashi Shida, Daiki Okamura, Masaru Miyazaki

Open Access Research article

Space-time clustering of childhood central nervous system tumours in Yorkshire, UK

Richard JQ McNally, Peter W James, Susan V Picton, Patricia A McKinney, Marlous van Laar, Richard G Feltbower

Open Access Research article

The cyclin-like protein Spy1/RINGO promotes mammary transformation and is elevated in human breast cancer

Mohammad Al Sorkhy, Rosa-Maria Ferraiuolo, Espanta Jalili, Agnes Malysa, Andreea R Fratiloiu, Bonnie F Sloane, Lisa A Porter

Open Access Research article

Methylation of the KEAP1 gene promoter region in human colorectal cancer

Naoyuki Hanada, Takenori Takahata, Qiliang Zhou, Xulu Ye, Ruowen Sun, Jugoh Itoh, Atsushi Ishiguro, Hiroshi Kijima, Junsei Mimura, Ken Itoh, Shinsaku Fukuda, Yasuo Saijo

Open Access Research article

DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

Hilmar Quentmeier, Sonja Eberth, Julia Romani, Herbert A Weich, Margarete Zaborski, Hans G Drexler

Open Access Research article

Disruption of CTCF at the miR-125b1 locus in gynecological cancers

Ernesto Soto-Reyes, Rodrigo González-Barrios, Fernanda Cisneros-Soberanis, Roberto Herrera-Goepfert, Víctor Pérez, David Cantú, Diddier Prada, Clementina Castro, Félix Recillas-Targa, Luis A Herrera

Open Access Research article

Brain metastases from hepatocellular carcinoma: clinical features and prognostic factors

Xiao-Bing Jiang, Chao Ke, Guan-Hua Zhang, Xiang-Heng Zhang, Ke Sai, Zhong-Ping Chen, Yong-Gao Mou

Open Access Study protocol

Laparoscopy to predict the result of primary cytoreductive surgery in advanced ovarian cancer patients (LapOvCa-trial): a multicentre randomized controlled study

Marianne J Rutten, Katja N Gaarenstroom, Toon Van Gorp, Hannah S van Meurs, Henriette JG Arts, Patrick M Bossuyt, Henk G Ter Brugge, Ralph HM Hermans, Brent C Opmeer, Johanna MA Pijnenborg, Henk WR Schreuder, Eltjo MJ Schutter, Anje M Spijkerboer, Celesta WM Wensveen, Petra Zusterzeel, Ben Willem J Mol, Gemma G Kenter, Marrije R Buist

Open Access Research article

Effects of partner proteins on BCA2 RING ligase activity

Stephanie Bacopulos, Yutaka Amemiya, Wenyi Yang, Judit Zubovits, Angelika Burger, Martin Yaffe, Arun K Seth

Open Access Study protocol

Improving adherence to surveillance and screening recommendations for people with colorectal cancer and their first degree relatives: a randomized controlled trial

Mariko Carey, Rob Sanson-Fisher, Finlay Macrae, David Hill, Catherine D'Este, Christine Paul, Christopher Doran

Open Access Research article

Cancer-initiating cells derived from established cervical cell lines exhibit stem-cell markers and increased radioresistance

Jacqueline López, Adela Poitevin, Veverly Mendoza-Martínez, Carlos Pérez-Plasencia, Alejandro García-Carrancá

Open Access Research article

Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer

Jing Shi, Demao Yao, Wei Liu, Na Wang, Hongjun Lv, Guanjun Zhang, Meiju Ji, Li Xu, Nongyue He, Bingyin Shi, Peng Hou

Open Access Research article

Peripheral T-lymphocytes express WNT7A and its restoration in leukemia-derived lymphoblasts inhibits cell proliferation

Alejandra B Ochoa-Hernández, Moisés Ramos-Solano, Ivan D Meza-Canales, Beatriz García-Castro, Mónica A Rosales-Reynoso, Judith A Rosales-Aviña, Esperanza Barrera-Chairez, Pablo C Ortíz-Lazareno, Georgina Hernández-Flores, Alejandro Bravo-Cuellar, Luis F Jave-Suarez, Patricio Barros-Núñez, Adriana Aguilar-Lemarroy

Open Access Research article

PINCH is an independent prognostic factor in rectal cancer patients without preoperative radiotherapy - a study in a Swedish rectal cancer trial of preoperative radiotherapy

Annica Holmqvist, Jingfang Gao, Birgitta Holmlund, Gunnar Adell, John Carstensen, Dianne Langford, Xiao-Feng Sun

Open Access Research article

Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries

Erika Maria Monteiro Santos, Mev Dominguez Valentin, Felipe Carneiro, Ligia Petrolini de Oliveira, Fabio de Oliveira Ferreira, Samuel Aguiar Junior, Wilson Toshihiko Nakagawa, Israel Gomy, Victor Evangelista de Faria Ferraz, Wilson Araujo da Silva Junior, Dirce Maria Carraro, Benedito Mauro Rossi

Open Access Research article

Frequency of CDH1 germline mutations in gastric carcinoma coming from high- and low-risk areas: metanalysis and systematic review of the literature

Giovanni Corso, Daniele Marrelli, Valeria Pascale, Carla Vindigni, Franco Roviello

Open Access Research article

Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia

Marcela Braga Mansur, Rocio Hassan, Thayana C Barbosa, Alessandra Splendore, Patricia Y Jotta, José Andrés Yunes, Joseph L Wiemels, Maria S Pombo-de-Oliveira

Open Access Research article

Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers

Na Young Jang, Keun-Wook Lee, Soon-Hyun Ahn, Jae-Sung Kim, In-Ah Kim

Open Access Research article

HPV type-related chromosomal profiles in high-grade cervical intraepithelial neoplasia

Mariska Bierkens, Saskia M Wilting, Wessel N van Wieringen, Mark A van de Wiel, Bauke Ylstra, Chris JLM Meijer, Peter JF Snijders, Renske DM Steenbergen

Open Access Research article

Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis

Zhigang Cui, Zhihua Yin, Xuelian Li, Wei Wu, Peng Guan, Baosen Zhou

Open Access Research article

ADAM8 in squamous cell carcinoma of the head and neck: a retrospective study

Valerie Zielinski, Markus Brunner, Gregor Heiduschka, Sven Schneider, Rudolf Seemann, Boban Erovic, Dietmar Thurnher

Open Access Research article

Androgenic suppression combined with radiotherapy for the treatment of prostate adenocarcinoma: a systematic review

André D Sasse, Elisa Sasse, Albertina M Carvalho, Ligia T Macedo

Open Access Research article

Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development

Kwong-Him To, Sanja Pajovic, Brenda L Gallie, Brigitte L Thériault

Open Access Research article

RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls

Mikkel Noerholm, Leonora Balaj, Tobias Limperg, Afshin Salehi, Lin Dan Zhu, Fred H Hochberg, Xandra O Breakefield, Bob S Carter, Johan Skog

Open Access Research article

Survival after chemotherapy and/or radiotherapy versus self-expanding metal stent insertion in the setting of inoperable esophageal cancer: a case-control study

George Sgourakis, Ines Gockel, Constantine Karaliotas, Markus Moehler, Carl Christoph Schimanski, Heinz Schmidberger, Theodor Junginger

Open Access Research article

Monitoring physical and psychosocial symptom trajectories in ovarian cancer patients receiving chemotherapy

Verena Meraner, Eva-Maria Gamper, Anna Grahmann, Johannes M Giesinger, Petra Wiesbauer, Monika Sztankay, Alain G Zeimet, Barbara Sperner-Unterweger, Bernhard Holzner

Open Access Research article

Prognostic value of metabolic response in breast cancer patients receiving neoadjuvant chemotherapy

Maria D Cao, Guro F Giskeødegård, Tone F Bathen, Beathe Sitter, Anna Bofin, Per E Lønning, Steinar Lundgren, Ingrid S Gribbestad

Open Access Research article

The application of methylation specific electrophoresis (MSE) to DNA methylation analysis of the 5' CpG island of mucin in cancer cells

Seiya Yokoyama, Sho Kitamoto, Norishige Yamada, Izumi Houjou, Tamotsu Sugai, Shin-ichi Nakamura, Yoshifumi Arisaka, Kyoichi Takaori, Michiyo Higashi, Suguru Yonezawa

Open Access Research article

Human chorionic gonadotropin and its relation to grade, stage and patient survival in ovarian cancer

Miriam Lenhard, Alexandra Tsvilina, Lan Schumacher, Markus Kupka, Nina Ditsch, Doris Mayr, Klaus Friese, Udo Jeschke

Open Access Research article

The association between Toll-like receptor 2 single-nucleotide polymorphisms and hepatocellular carcinoma susceptibility

Xie Junjie, Jiang Songyao, Shi Minmin, Song Yanyan, Shen Baiyong, Deng Xiaxing, Jin Jiabin, Zhan Xi, Chen Hao

Open Access Research article

Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

Peter S Harris, Sujatha Venkataraman, Irina Alimova, Diane K Birks, Andrew M Donson, Jeffrey Knipstein, Adrian Dubuc, Michael D Taylor, Michael H Handler, Nicholas K Foreman, Rajeev Vibhakar

Open Access Research article

The predictive value of microRNA-126 in relation to first line treatment with capecitabine and oxaliplatin in patients with metastatic colorectal cancer

Torben Frøstrup Hansen, Flemming Brandt Sørensen, Jan Lindebjerg, Anders Jakobsen

Open Access Research article

KAI1 suppresses HIF-1α and VEGF expression by blocking CDCP1-enhanced Src activation in prostate cancer

Jung-Jin Park, Yeung Bae Jin, Yoon-Jin Lee, Jae-Seon Lee, Yun-Sil Lee, Young-Gyu Ko, Minyoung Lee

Open Access Research article

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Anne-Katrine Bonde, Verena Tischler, Sushil Kumar, Alex Soltermann, Reto A Schwendener

Open Access Research article

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

Benjamin Blaser, Laurent Waselle, Anne Dormond-Meuwly, Marc Dufour, Didier Roulin, Nicolas Demartines, Olivier Dormond

Open Access Case report

Pneumatosis intestinalis and portal venous gas secondary to Gefitinib therapy for lung adenocarcinoma

Joo Young Lee, Hye-Suk Han, Sung-Nam Lim, Young Kwang Shim, Yong Hyeok Choi, Ok-Jun Lee, Ki Hyeong Lee, Seung Taik Kim

Open Access Research article

A population-based cohort study of chest x-ray screening in smokers: lung cancer detection findings and follow-up

Lorenzo Dominioni, Nicola Rotolo, William Mantovani, Albino Poli, Salvatore Pisani, Valentina Conti, Massimo Paolucci, Fausto Sessa, Antonio Paddeu, Vincenzo D'Ambrosio, Andrea Imperatori

Open Access Research article

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families

Juana Fernández-Rodríguez, Francisco Quiles, Ignacio Blanco, Alex Teulé, Lídia Feliubadaló, Jesús del Valle, Mónica Salinas, Àngel Izquierdo, Esther Darder, Detlev Schindler, Gabriel Capellá, Joan Brunet, Conxi Lázaro, Miguel Angel Pujana

Open Access Research article

Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases

Hidekazu Kuramochi, Go Nakajima, Yuka Kaneko, Ayako Nakamura, Yuji Inoue, Masakazu Yamamoto, Kazuhiko Hayashi

Open Access Research article

Identification of a biomarker panel for colorectal cancer diagnosis

Amaia García-Bilbao, Rubén Armañanzas, Ziortza Ispizua, Begoña Calvo, Ana Alonso-Varona, Iñaki Inza, Pedro Larrañaga, Guillermo López-Vivanco, Blanca Suárez-Merino, Mónica Betanzos

Open Access Research article

Downregulation of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) in human hepatocellular carcinoma and their prognostic significance

Michael Heise, Anja Lautem, Johanna Knapstein, Jörn M Schattenberg, Maria Hoppe-Lotichius, Daniel Foltys, Nina Weiler, Anca Zimmermann, Arno Schad, Dirk Gründemann, Gerd Otto, Peter R Galle, Marcus Schuchmann, Tim Zimmermann

Open Access Study protocol

Clinical phase I/II trial to investigate neoadjuvant intensity-modulated short term radiation therapy (5 × 5 gy) and intraoperative radiation therapy (15 gy) in patients with primarily resectable pancreatic cancer - NEOPANC

Falk Roeder, Carmen Timke, Ladan Saleh-Ebrahimi, Lutz Schneider, Thilo Hackert, Werner Hartwig, Annette Kopp-Schneider, Frank W Hensley, Markus W Buechler, Juergen Debus, Peter E Huber, Jens Werner

Open Access Research article

The mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study

Christiana A Demetriou, Andreas Hadjisavvas, Maria A Loizidou, Giorgos Loucaides, Ioanna Neophytou, Sabina Sieri, Eleni Kakouri, Nicos Middleton, Paolo Vineis, Kyriacos Kyriacou

Open Access Research article

Systematic review: conservative treatments for secondary lymphedema

Mark Oremus, Ian Dayes, Kathryn Walker, Parminder Raina

Open Access Research article

The TERT rs2736100 Polymorphism and Cancer Risk: A Meta-analysis Based on 25 Case-Control Studies

Peng Zou, Aihua Gu, Guixiang Ji, Lin Zhao, Peng Zhao, Ailin Lu

Open Access Research article

Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma

Hunain Alam, Amruta V Bhate, Prakash Gangadaran, Sharda S Sawant, Shimul Salot, Lalit Sehgal, Prerana P Dange, Devendra A Chaukar, Anil K D'cruz, Sadhna Kannanl, Rajiv Gude, Shubhada Kane, Sorab N Dalal, Milind M Vaidya

Open Access Research article

Anticipating implementation of colorectal cancer screening in The Netherlands: a nation wide survey on endoscopic supply and demand

Sietze T van Turenhout, Jochim S Terhaar sive Droste, Gerrit A Meijer, Ad A Masclée, Chris JJ Mulder

Open Access Research article

Loss of miR-133a expression associated with poor survival of breast cancer and restoration of miR-133a expression inhibited breast cancer cell growth and invasion

Zheng-sheng Wu, Chao-qun Wang, Ru Xiang, Xue Liu, Shan Ye, Xue-qing Yang, Gui-hong Zhang, Xiao-chun Xu, Tao Zhu, Qiang Wu

Open Access Research article

aThe dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer

Gustaf Rosin, Ulf Hannelius, Linda Lindström, Per Hall, Jonas Bergh, Johan Hartman, Juha Kere

Open Access Research article

Proteins and carbohydrates in nipple aspirate fluid predict the presence of atypia and cancer in women requiring diagnostic breast biopsy

Wenyi Qin, Gerald Gui, Ke Zhang, Dominique Twelves, Beth Kliethermes, Edward R Sauter

Open Access Research article

Mortality in cancer patients with a history of cutaneous squamous cell carcinoma - a nationwide population-based cohort study

Sigrun Alba Johannesdottir, Timothy L Lash, Annette Østergaard Jensen, Dóra Körmendiné Farkas, Anne Braae Olesen

Open Access Research article

Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Bang Hu, Donglin Ren, Dan Su, Hongcheng Lin, Zhenyu Xian, Xingyang Wan, Junxiao Zhang, Xinhui Fu, Li Jiang, Dechan Diao, Xinjuan Fan, Lei Wang, Jianping Wang

Open Access Research article

Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells

Miguel A Mendoza-Catalán, Gema R Cristóbal-Mondragón, Jesús Adame-Gómez, Heidi N del Valle-Flores, José Fco Coppe, Laura Sierra-López, Mirna A Romero-Hernández, Luz del Carmen Alarcón-Romero, Berenice Illades-Aguiar, Eduardo Castañeda-Saucedo

Open Access Research article

Prognostic significance of anti-p53 and anti-KRas circulating antibodies in esophageal cancer patients treated with chemoradiotherapy

Pierre Blanchard, Laurent Quero, Vincent Pacault, Marie-Helene Schlageter, Valerie Baruch-Hennequin, Christophe Hennequin

Open Access Research article

A mouse model for triple-negative breast cancer tumor-initiating cells (TNBC-TICs) exhibits similar aggressive phenotype to the human disease

Punit Kaur, Ganachari M Nagaraja, Hongying Zheng, Dawit Gizachew, Moses Galukande, Sunil Krishnan, Alexzander Asea

Open Access Research article

Breast cancer stage at diagnosis and area-based socioeconomic status: a multicenter 10-year retrospective clinical epidemiological study in China

Qiong Wang, Jing Li, Shan Zheng, Jia-Yuan Li, Yi Pang, Rong Huang, Bao-Ning Zhang, Bin Zhang, Hong-Jian Yang, Xiao-Ming Xie, Zhong-Hua Tang, Hui Li, Jian-Jun He, Jin-Hu Fan, You-Lin Qiao

Open Access Research article

AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model

Qin Jie Wu, Chang Yang Gong, Shun Tao Luo, Dong Mei Zhang, Shuang Zhang, Hua Shan Shi, Lian Lu, Heng Xiu Yan, Sha Sha He, Dan Dan Li, Li Yang, Xia Zhao, Yu Quan Wei

Open Access Research article

Promising treatment outcomes of intensity-modulated radiation therapy for nasopharyngeal carcinoma patients with N0 disease according to the seventh edition of the AJCC staging system

Ying Sun, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Li-Zhi Liu, Ai-Hua Lin, Li Li, Jun Ma

Open Access Research article

Cytoplasmic BRMS1 expression in malignant melanoma is associated with increased disease-free survival

Ana Slipicevic, Ruth Holm, Elisabeth Emilsen, Anne Katrine Ree Rosnes, Danny R Welch, Gunhild M Mælandsmo, Vivi Ann Flørenes

Open Access Correspondence

Report on emerging technologies for translational bioinformatics: a symposium on gene expression profiling for archival tissues

Levi Waldron, Peter Simpson, Giovanni Parmigiani, Curtis Huttenhower

Open Access Research article

Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells

Gustavo A Acuña Sanhueza, Leonie Faller, Babitha George, Jennifer Koffler, Vinko Misetic, Christa Flechtenmacher, Gerhard Dyckhoff, Peter P Plinkert, Peter Angel, Christian Simon, Jochen Hess

Open Access Research article

Clinical relevance of ErbB-2/HER2 nuclear expression in breast cancer

Roxana Schillaci, Pablo Guzmán, Florencia Cayrol, Wendy Beguelin, María C Díaz Flaqué, Cecilia J Proietti, Viviana Pineda, Jorge Palazzi, Isabel Frahm, Eduardo H Charreau, Esteban Maronna, Juan C Roa, Patricia V Elizalde

Open Access Research article

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

Alexandria M Haslehurst, Madhuri Koti, Moyez Dharsee, Paulo Nuin, Ken Evans, Joseph Geraci, Timothy Childs, Jian Chen, Jieran Li, Johanne Weberpals, Scott Davey, Jeremy Squire, Paul C Park, Harriet Feilotter

Open Access Research article

EMMPRIN/CD147 up-regulates urokinase-type plasminogen activator: implications in oral tumor progression

Géraldine Lescaille, Suzanne Menashi, Bénédicte Cavelier-Balloy, Farah Khayati, Cathy Quemener, Marie Pierre Podgorniak, Benyoussef Naïmi, Fabien Calvo, Céleste Lebbe, Samia Mourah

Open Access Commentary

The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?

Jonathan Krell, Adam E Frampton, Justin Stebbing

Open Access Study protocol

Phase I/II trial evaluating carbon ion radiotherapy for the treatment of recurrent rectal cancer: the PANDORA-01 trial

Stephanie E Combs, Meinhard Kieser, Daniel Habermehl, Jürgen Weitz, Dirk Jäger, Piero Fossati, Roberto Orrechia, Rita Engenhart-Cabillic, Richard Pötter, Manjit Dosanjh, Oliver Jäkel, Markus W Büchler, Jürgen Debus

Open Access Study protocol

LICC: L-BLP25 in patients with colorectal carcinoma after curative resection of hepatic metastases--a randomized, placebo-controlled, multicenter, multinational, double-blinded phase II trial

Carl Christoph Schimanski, Markus Möhler, Michael Schön, Eric van Cutsem, Richard Greil, Wolf Otto Bechstein, Susanna Hegewisch-Becker, Götz von Wichert, Matthias Vöhringer, Michael Heike, Volker Heinemann, Marc Peeters, Stephan Kanzler, Stefan Kasper, Friedrich Overkamp, Jan Schröder, Daniel Seehofer, Frank Kullmann, Bernhard Linz, Irene Schmidtmann, Victoria Smith-Machnow, Ines Gockel, Hauke Lang, Peter R Galle

Open Access Research article

Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics

Armin Haupt, Gerard Joberty, Marcus Bantscheff, Holger Fröhlich, Henning Stehr, Michal R Schweiger, Axel Fischer, Martin Kerick, Stefan T Boerno, Andreas Dahl, Michael Lappe, Hans Lehrach, Cayetano Gonzalez, Gerard Drewes, Bodo MH Lange

Open Access Research article

Relevance of activated leukocyte cell adhesion molecule (ALCAM) in tumor tissue and sera of cervical cancer patients

Maike Ihnen, Kerstin Kress, Jan Felix Kersten, Ergin Kilic, Matthias Choschzick, Hilke Zander, Volkmar Müller, Sven Mahner, Fritz Jänicke, Linn Woelber, Karin Milde-Langosch

Open Access Study protocol

Resection of the primary tumour versus no resection prior to systemic therapy in patients with colon cancer and synchronous unresectable metastases (UICC stage IV): SYNCHRONOUS - a randomised controlled multicentre trial (ISRCTN30964555)

Nuh N Rahbari, Florian Lordick, Christine Fink, Ulrich Bork, Annika Stange, Dirk Jäger, Steffen P Luntz, Stefan Englert, Inga Rossion, Moritz Koch, Markus W Büchler, Meinhard Kieser, Jürgen Weitz

Open Access Research article

Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events

Kate M Peters, Stacey L Edwards, Shalima S Nair, Juliet D French, Peter J Bailey, Kathryn Salkield, Sandra Stein, Sarah Wagner, Glenn D Francis, Susan J Clark, Melissa A Brown

Open Access Research article

REGγ is associated with multiple oncogenic pathways in human cancers

Jing He, Long Cui, Yu Zeng, Guangqiang Wang, Ping Zhou, Yuanyuan Yang, Lei Ji, Yanyan Zhao, Jiwu Chen, Zhuo Wang, Tieliu Shi, Pei Zhang, Rui Chen, Xiaotao Li

Open Access Study protocol

Tri-Modality therapy with I-125 brachytherapy, external beam radiation therapy, and short- or long-term hormone therapy for high-risk localized prostate cancer (TRIP): study protocol for a phase III, multicenter, randomized, controlled trial

Hiroyuki Konaka, Shin Egawa, Shiro Saito, Atsunori Yorozu, Hiroyuki Takahashi, Keiko Miyakoda, Masanori Fukushima, Takushi Dokiya, Hidetoshi Yamanaka, Nelson N Stone, Mikio Namiki

Open Access Research article

miRNA-135a promotes breast cancer cell migration and invasion by targeting HOXA10

Yating Chen, Jin Zhang, Huijun Wang, Jiayi Zhao, Cheng Xu, Yingying Du, Xin Luo, Fengyun Zheng, Rui Liu, Hongwei Zhang, Duan Ma

Open Access Research article

Genetic polymorphisms in MMP 2, 9 and 3genes modify lung cancer risk and survival

Patricia González-Arriaga, Teresa Pascual, Arturo García-Alvarez, Ana Fernández-Somoano, M Felicitas López-Cima, Adonina Tardón

Open Access Study protocol

Monitoring of patients treated with particle therapy using positron-emission-tomography (PET): the MIRANDA study

Stephanie E Combs, Julia Bauer, Daniel Unholtz, Christopher Kurz, Thomas Welzel, Daniel Habermehl, Thomas Haberer, Jürgen Debus, Katia Parodi

Open Access Correspondence

Improving quality of breast cancer surgery through development of a national breast cancer surgical outcomes (BRCASO) research database

Erin J Aiello Bowles, Heather Spencer Feigelson, Tom Barney, Katherine Broecker, Andrew Sterrett, Kimberly Bischoff, Jessica Engel, Gabrielle Gundersen, Johanna Sheehey-Jones, Richard Single, Adedayo Onitilo, Ted A James, Laurence E McCahill

Open Access Research article

Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site

Frederick Albright, Craig Teerlink, Theresa L Werner, Lisa A Cannon-Albright

Open Access Research article

HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis

Carolina Cavalcante Bitu, Maria Fernanda de Souza Setúbal Destro, Manoela Carrera, Sabrina Daniela da Silva, Edgard Graner, Luiz Paulo Kowalski, Fernando Augusto Soares, Ricardo D Coletta

Open Access Research article

Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line

Sara R Martins-Neves, Áurio O Lopes, Anália do Carmo, Artur A Paiva, Paulo C Simões, Antero J Abrunhosa, Célia MF Gomes

Open Access Research article

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

Ji Eun Kim, Clare Stones, Wayne R Joseph, Euphemia Leung, Graeme J Finlay, Andrew N Shelling, Wayne A Phillips, Peter R Shepherd, Bruce C Baguley

Open Access Research article

Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C

Kyu Kwang Kim, Thilo S Lange, Rakesh K Singh, Laurent Brard, Richard G Moore

Open Access Study protocol

Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial

Takuma Higurashi, Hirokazu Takahashi, Hiroki Endo, Kunihiro Hosono, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Takashi Uchiyama, Yasuo Hata, Nobutaka Fujisawa, Shiori Uchiyama, Akiko Ezuka, Hajime Nagase, Takaomi Kessoku, Nobuyuki Matsuhashi, Shoji Yamanaka, Yoshiaki Inayama, Satoshi Morita, Atsushi Nakajima

Open Access Research article

PRAF3 induces apoptosis and inhibits migration and invasion in human esophageal squamous cell carcinoma

Guo-Zhen Shi, Yang Yuan, Guo-Jun Jiang, Zhi-Jun Ge, Jian Zhou, De-Jun Gong, Jing Tao, Yong-Fei Tan, Sheng-Dong Huang

Open Access Research article

Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: A meta-analysis of clinical evidence

Francis CH Ho, Ivan WK Tham, Arul Earnest, Khai Mun Lee, Jiade J Lu

Open Access Research article

Increased serum sTRAIL levels were correlated with survival in bevacizumab-treated metastatic colon cancer

Atil Bisgin, Aysegul Kargi, Arzu D Yalcin, Cigdem Aydin, Deniz Ekinci, Burhan Savas, Salih Sanlioglu

Open Access Research article

Fibronectin matrix-mediated cohesion suppresses invasion of prostate cancer cells

Dongxuan Jia, Ildiko Entersz, Christine Butler, Ramsey A Foty

Open Access Research article

The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study

Piotr Rutkowski, Elżbieta Bylina, Anna Klimczak, Tomasz Świtaj, Sławomir Falkowski, Jacek Kroc, Iwona Ługowska, Magdalena Brzeskwiniewicz, Wojciech Melerowicz, Czesław Osuch, Ewa Mierzejewska, Kacper Wasielewski, Agnieszka Woźniak, Urszula Grzesiakowska, Zbigniew I Nowecki, Janusz A Siedlecki, Janusz Limon

Open Access Study protocol

A pilot study of exercise in men with prostate cancer receiving androgen deprivation therapy

C Ellen Lee, William D Leslie, YK James Lau

Open Access Research article

Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+tumor infiltrating lymphocytes in ductal and lobular breast cancers

Raoul Droeser, Inti Zlobec, Ergin Kilic, Uwe Güth, Michael Heberer, Giulio Spagnoli, Daniel Oertli, Coya Tapia

Open Access Research article

The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

Laurie Hamtiaux, Julien Masquelier, Giulio G Muccioli, Caroline Bouzin, Olivier Feron, Bernard Gallez, Didier M Lambert

Open Access Research article

Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

Andrea Malfettone, Concetta Saponaro, Angelo Paradiso, Giovanni Simone, Annita Mangia

Open Access Research article

Methylation profiling of Epstein-Barr virus immediate-early gene promoters, BZLF1 and BRLF1in tumors of epithelial, NK- and B-cell origins

Lili Li, Xianwei Su, Gigi Ching Gee Choi, Ya Cao, Richard F Ambinder, Qian Tao

Open Access Research article

Survival of endometrial cancer patients in Germany in the early 21st century: a period analysis by age, histology, and stage

Tianhui Chen, Lina Jansen, Adam Gondos, Meike Ressing, Bernd Holleczek, Alexander Katalinic, Hermann Brenner

Open Access Research article

Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

Jerry Call, Christopher D Walentas, Jens C Eickhoff, Norman Scherzer

Open Access Research article

Properties of resistant cells generated from lung cancer cell lines treated with EGFR inhibitors

Gargi Ghosh, Xiaojun Lian, Stephen J Kron, Sean P Palecek

Open Access Research article

Synthetic Lethal Screen Identifies NF-κB as a Target for Combination Therapy with Topotecan for patients with Neuroblastoma

Patricia S Tsang, Adam T Cheuk, Qing-Rong Chen, Young K Song, Thomas C Badgett, Jun S Wei, Javed Khan

Open Access Research article

Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

Matias E Valsecchi, Thomas Holdbrook, Benjamin E Leiby, Edward Pequignot, Susan J Littman, Charles J Yeo, Jonathan R Brody, Agnieszka K Witkiewicz

Open Access Research article

Mesenchymal and stemness circulating tumor cells in early breast cancer diagnosis

Guislaine Barrière, Alain Riouallon, Joël Renaudie, Michel Tartary, Michel Rigaud

Open Access Research article

Prognostic impact of mRNA levels of osteopontin splice variants in soft tissue sarcoma patients

Antje Hahnel, Henri Wichmann, Thomas Greither, Matthias Kappler, Peter Würl, Matthias Kotzsch, Helge Taubert, Dirk Vordermark, Matthias Bache

Open Access Study protocol

A phase II study for metabolic in vivo response monitoring with sequential 18FDG-PET-CT during treatment with the EGFR-monoclonal-antibody cetuximab in metastatic colorectal cancer: the Heidelberg REMOTUX trial

Anne Katrin Berger, Carl von Gall, Ulrich Abel, Stefan Delorme, Matthias Kloor, Jennifer Ose, Tim Frederik Weber, Annika Stange, Georg Martin Haag, Uwe Haberkorn, Florian Lordick, Dirk Jäger

Open Access Research article

Characterization of colon cancer cells: a functional approach characterizing CD133 as a potential stem cell marker

Meike Schneider, Johannes Huber, Boris Hadaschik, Gabrielle M Siegers, Heinz-Herbert Fiebig, Julia Schüler

Open Access Research article

Esthesioneuroblastoma in pediatric and adolescent age. A report from the TREP project in cooperation with the Italian Neuroblastoma and Soft Tissue Sarcoma Committees

Gianni Bisogno, Pietro Soloni, Massimo Conte, Marta Podda, Andrea Ferrari, Alberto Garaventa, Roberto Luksch, Giovanni Cecchetto

Open Access Research article

Ezrin phosphorylation on tyrosine 477 regulates invasion and metastasis of breast cancer cells

Hannah Mak, Alexandra Naba, Sonal Varma, Colleen Schick, Andrew Day, Sandip K SenGupta, Monique Arpin, Bruce E Elliott

Open Access Research article

TRAIL receptor I (DR4) polymorphisms C626G and A683C are associated with an increased risk for hepatocellular carcinoma (HCC) in HCV-infected patients

Christian Körner, Katarina Riesner, Benjamin Krämer, Marianne Eisenhardt, Andreas Glässner, Franziska Wolter, Thomas Berg, Tobias Müller, Tilman Sauerbruch, Jacob Nattermann, Ulrich Spengler, Hans Dieter Nischalke

Open Access Research article

JS-K, a glutathione/glutathione S-transferase-activated nitric oxide releasing prodrug inhibits androgen receptor and WNT-signaling in prostate cancer cells

Martin Laschak, Klaus-Dieter Spindler, Andres J Schrader, Andrea Hessenauer, Wolfgang Streicher, Mark Schrader, Marcus V Cronauer

Open Access Research article

Serial selection for invasiveness increases expression of miR-143/miR-145 in glioblastoma cell lines

Sunwoo Koo, Gail S Martin, Kevin J Schulz, Matthew Ronck, L Gerard Toussaint

Open Access Research article

Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy

Carlos D Gamarra-Luques, Alicia A Goyeneche, Maria B Hapon, Carlos M Telleria

Open Access Technical advance

Isolation and genomic analysis of circulating tumor cells from castration resistant metastatic prostate cancer

Mark Jesus M Magbanua, Eduardo V Sosa, Janet H Scott, Jeff Simko, Colin Collins, Dan Pinkel, Charles J Ryan, John W Park

Open Access Research article

Interleukin-10-819 promoter polymorphism in association with gastric cancer risk

Huiping Xue, Bing Lin, Jianfu An, Yuyuan Zhu, Gang Huang

Open Access Research article

SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

Maria Tengström, Arto Mannermaa, Veli-Matti Kosma, Ari Hirvonen, Vesa Kataja

Open Access Research article

Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

Fatima A Haggar, David B Preen, Gavin Pereira, Cashel DJ Holman, Kristjana Einarsdottir

Open Access Research article

Adeno-associated virus-mediated doxycycline-regulatable TRAIL expression suppresses growth of human breast carcinoma in nude mice

Liu Zheng, Zhang Weilun, Jiang Minghong, Zhang Yaxi, Liu Shilian, Liu Yanxin, Zheng Dexian

Open Access Research article

Inhibitory effect of Bifidobacterium infantis-mediated sKDR prokaryotic expression system on angiogenesis and growth of Lewis lung cancer in mice

Zhao-Jun Li, Hong Zhu, Bu-Yun Ma, Fen Zhao, Shu-Hua Mao, Tai-Guo Liu, Jian-Ping He, Li-Cong Deng, Cheng Yi, Ying Huang

Open Access Research article

Copper compound induces autophagy and apoptosis of glioma cells by reactive oxygen species and jnk activation

Cristina Trejo-Solís, Dolores Jimenez-Farfan, Sara Rodriguez-Enriquez, Francisca Fernandez-Valverde, Arturo Cruz-Salgado, Lena Ruiz-Azuara, Julio Sotelo

Open Access Research article

Adjuvant chemotherapy of pT1a and pT1b breast carcinoma: results from the NEMESI study

Stefania Gori, Matteo Clavarezza, Salvatore Siena, Jennifer Foglietta, Emiliana Tarenzi, Monica Giordano, Annamaria Molino, Claudio Graiff, Vittorio Fusco, Oscar Alabiso, Editta Baldini, Teresa Gamucci, Giuseppe Altavilla, Davide Dondi, Marco Venturini

Open Access Research article

The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China

Shizhuo Wang, Heng Wei, Ning Wang, Shulan Zhang, Yao Zhang, Qiang Ruan, Weiguo Jiang, Qian Xiao, Xiaomei Luan, Xiuyan Qian, Lili Zhang, Xiang Gao, Xiaowei Sun

Open Access Research article

Customized chemotherapy based on epidermal growth factor receptormutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial

Shiro Fujita, Nobuyuki Katakami, Katsuhiro Masago, Hiroshige Yoshioka, Keisuke Tomii, Toshihiko Kaneda, Masataka Hirabayashi, Kei Kunimasa, Toshio Morizane, Tadashi Mio

Open Access Case report

Imatinib-induced liver cirrhosis in a patient with advanced gastrointestinal stroma tumor (GIST)

Christoph Seidel, Martin Fenner, Florian Länger, Heike Bantel, Arnold Ganser, Viktor Grünwald

Open Access Research article

ERCC1 as a biomarker for bladder cancer patients likely to benefit from adjuvant chemotherapy

Jong-Mu Sun, Ji-Youn Sung, Se Hoon Park, Ghee Young Kwon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Jisuk Jo, Han Yong Choi, Ho Yeong Lim

Open Access Research article

A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma

Peter J Hosein, Jessica Macintyre, Carolina Kawamura, Jennifer Cudris Maldonado, Vinicius Ernani, Arturo Loaiza-Bonilla, Govindarajan Narayanan, Afonso Ribeiro, Lorraine Portelance, Jaime R Merchan, Joe U Levi, Caio M Rocha-Lima

Open Access Technical advance

Detection of circulating tumor cells in blood of metastatic breast cancer patients using a combination of cytokeratin and EpCAM antibodies

Ulrike Weissenstein, Agnes Schumann, Marcus Reif, Susanne Link, Ulrike D Toffol-Schmidt, Peter Heusser

Open Access Research article

MGMT, GATA6, CD81, DR4, and CASP8 gene promoter methylation in glioblastoma

Daina Skiriute, Paulina Vaitkiene, Viktoras Saferis, Virginija Asmoniene, Kestutis Skauminas, Vytenis Pranas Deltuva, Arimantas Tamasauskas

Open Access Research article

Plant HDAC inhibitor chrysin arrest cell growth and induce p21 WAF1 by altering chromatin of STAT response element in A375 cells

Manika Pal-Bhadra, M Janaki Ramaiah, T Lakshminarayan Reddy, Anita Krishnan, SNCVL Pushpavalli, K Suresh Babu, Ashok K Tiwari, J Madhusudana Rao, Jhillu S Yadav, Utpal Bhadra

Open Access Research article

Clinical significance of erythropoietin receptor expression in oral squamous cell carcinoma

Yu-Tsai Lin, Hui-Ching Chuang, Chang-Han Chen, Gian Luca Armas, Han-Ku Chen, Fu-Min Fang, Chao-Cheng Huang, Chih-Yen Chien

Open Access Research article

Total and individual antioxidant intake and risk of epithelial ovarian cancer

Dina Gifkins, Sara H Olson, Lisa Paddock, Melony King, Kitaw Demissie, Shou-En Lu, Ah-Ng Tony Kong, Lorna Rodriguez-Rodriguez, Elisa V Bandera

Open Access Case report

Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report

Boban Stanojevic, Radan Dzodic, Vladimir Saenko, Zorka Milovanovic, Vesna Krstevski, Petar Radlovic, Marko Buta, Bozidar Rulic, Lidija Todorovic, Bogomir Dimitrijevic, Shunichi Yamashita

Open Access Research article

The role of cytochrome c oxidase subunit Va in non-small cell lung carcinoma cells: association with migration, invasion and prediction of distant metastasis

Wen-Liang Chen, Kuang-Tai Kuo, Teh-Ying Chou, Chien-Lung Chen, Chih-Hao Wang, Yau-Huei Wei, Liang-Shun Wang

Open Access Research article

IMRT and carbon ion boost for malignant salivary gland tumors: interim analysis of the COSMIC trial

Alexandra D Jensen, Anna V Nikoghosyan, Karen Lossner, Klaus K Herfarth, Jürgen Debus, Marc W Münter

Open Access Study protocol

Cervical cancer screening and adherence to follow-up among Hispanic women study protocol: a randomized controlled trial to increase the uptake of cervical cancer screening in Hispanic women

Catherine Duggan, Gloria Coronado, Javiera Martinez, Theresa L Byrd, Elizabeth Carosso, Cathy Lopez, Maria Benavides, Beti Thompson

Open Access Research article

The hypoxic microenvironment upgrades stem-like properties of ovarian cancer cells

Dongming Liang, Yuanyuan Ma, Jian Liu, Claes Goran Trope, Ruth Holm, Jahn M Nesland, Zhenhe Suo

Open Access Research article

NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

Brian A McCarthy, Liqun Yang, Jane Ding, Mingqiang Ren, William King, Mohammed ElSalanty, Ibrahim Zakhary, Mohamed Sharawy, Hongjuan Cui, Han-Fei Ding

Open Access Research article

Experimental in vivo and in vitro treatment with a new histone deacetylase inhibitor belinostat inhibits the growth of pancreatic cancer

Dmitriy I Dovzhanskiy, Stefanie M Arnold, Thilo Hackert, Ina Oehme, Olaf Witt, Klaus Felix, Nathalia Giese, Jens Werner

Open Access Case report

Development of coronary artery stenosis in a patient with metastatic renal cell carcinoma treated with sorafenib

Maria Abbondanza Pantaleo, Anna Mandrioli, Maristella Saponara, Margherita Nannini, Giovanna Erente, Cristian Lolli, Guido Biasco

Open Access Research article

The application of nonsense-mediated mRNA decay inhibition to the identification of breast cancer susceptibility genes

Julie K Johnson, Nic Waddell, Georgia Chenevix-Trench

Open Access Research article

Decreased survival among lung cancer patients with co-morbid tuberculosis and diabetes

Shwn-Huey Shieh, Janice C Probst, Fung-Chang Sung, Wen-Chen Tsai, Ya-Shin Li, Chih-Yi Chen

Open Access Research article

Feasibility of image-guided radiotherapy based on helical tomotherapy to reduce contralateral parotid dose in head and neck cancer

Nam P Nguyen, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Lexie Smith-Raymond, Michelle Stevie, Benjamin Slane, Alexander Chi, Anand Desai, Shane P Krafft, Siyoung Jang, Russ Hamilton, Ulf Karlsson, Dave Abraham

Open Access Technical advance

Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice

Agnieszka M Zagozdzon, Patrick O’Leary, John J Callanan, John Crown, William M Gallagher, Radoslaw Zagozdzon

Open Access Research article

Prognostic factors for different outcomes in patients with metastatic spinal cord compression from cancer of unknown primary

Sarah Douglas, Stefan Huttenlocher, Amira Bajrovic, Volker Rudat, Steven E Schild, Dirk Rades

Open Access Research article

The efficacy of TACE combined sorafenib in advanced stages hepatocellullar carcinoma

Xu-Dong Qu, Cheng-Shi Chen, Jian-Hua Wang, Zhi-ping Yan, Jie-min Chen, Gao-quan Gong, Qin-xin Liu, Jian-jun Luo, Lin-xiao Liu, Rong Liu, Sheng Qian

Open Access Research article

Hepatitis viruses infection and risk of intrahepatic cholangiocarcinoma: evidence from a meta-analysis

Yanming Zhou, Yanfang Zhao, Bin Li, Jiyi Huang, Lupeng Wu, Donghui Xu, Jiamei Yang, Jia He

Open Access Research article

ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer

Jing Zhong, Shujie Chen, Meng Xue, Qin Du, Jianting Cai, Hongchuan Jin, Jianmin Si, Liangjing Wang

Open Access Research article

Tumor stromal vascular endothelial growth factor A is predictive of poor outcome in inflammatory breast cancer

Hugo Arias-Pulido, Nabila Chaher, Yun Gong, Clifford Qualls, Jake Vargas, Melanie Royce

Open Access Research article

The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis

Kyou-Hoon Han, Si-Hyung Lee, Seon-Ah Ha, Hyun Kee Kim, CheWook Lee, Do-Hyoung Kim, Kee Hwan Gong, JinAh Yoo, Sanghee Kim, Jin Woo Kim

Open Access Research article

A validated survival score for patients with metastatic spinal cord compression from non-small cell lung cancer

Dirk Rades, Sarah Douglas, Theo Veninga, Steven E Schild

Open Access Research article

Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy

Wenyi Qin, Ke Zhang, Beth Kliethermes, Rachel L Ruhlen, Eva P Browne, Kathleen F Arcaro, Edward R Sauter

Open Access Research article

Clinical features and outcome of multiple primary malignancies involving hepatocellular carcinoma: A long-term follow-up study

Qing-An Zeng, Jiliang Qiu, Ruhai Zou, Yijie Li, Shengping Li, Binkui Li, Pinzhu Huang, Jian Hong, Yun Zheng, Xiangming Lao, Yunfei Yuan

Open Access Research article

The association between general practitioners’ attitudes towards breast cancer screening and women’s screening participation

Line Flytkjær Jensen, Thomas Ostersen Mukai, Berit Andersen, Peter Vedsted

Open Access Research article

Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells

Fritz Wimbauer, Caihong Yang, Kristen L Shogren, Minzhi Zhang, Ribu Goyal, Scott M Riester, Michael J Yaszemski, Avudaiappan Maran

Open Access Research article

CT-Screening for lung cancer does not increase the use of anxiolytic or antidepressant medication

Linda Kaerlev, Maria Iachina, Jesper Holst Pedersen, Anders Green, Bente Mertz Nørgård

Open Access Research article

Nuclear translocation of the cytoplasmic domain of HB-EGF induces gastric cancer invasion

Takaya Shimura, Michihiro Yoshida, Shinji Fukuda, Masahide Ebi, Yoshikazu Hirata, Tsutomu Mizoshita, Satoshi Tanida, Hiromi Kataoka, Takeshi Kamiya, Shigeki Higashiyama, Takashi Joh

Open Access Research article

Estimation of groin recurrence risk in patients with squamous cell vulvar carcinoma by the assessment of marker gene expression in the lymph nodes

Magdalena Kowalewska, Jakub Radziszewski, Krzysztof Goryca, Mateusz Bujko, Malgorzata Oczko-Wojciechowska, Michal Jarzab, Janusz Aleksander Siedlecki, Mariusz Bidzinski

Open Access Research article

Aggressive local treatment containing intraoperative radiation therapy (IORT) for patients with isolated local recurrences of pancreatic cancer: a retrospective analysis

Falk Roeder, Carmen Timke, Matthias Uhl, Gregor Habl, Frank W Hensley, Markus W Buechler, Robert Krempien, Peter E Huber, Juergen Debus, Jens Werner

Open Access Research article

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients

Catharina Medrek, Fredrik Pontén, Karin Jirström, Karin Leandersson

Open Access Study protocol

Implementation and scientific evaluation of rehabilitative sports groups for prostate cancer patients: study protocol of the ProRehab Study

Eva M Zopf, Moritz Braun, Stefan Machtens, Jürgen Zumbé, Wilhelm Bloch, Freerk T Baumann

Open Access Research article

Risk of second breast cancer in female Hodgkin’s lymphoma survivors: a meta-analysis

Ezzeldin M Ibrahim, Khaled M Abouelkhair, Ghieth A Kazkaz, Osama A Elmasri, Meteb Al-Foheidi

Open Access Research article

Antitumor activity of zoledronic acid in primary breast cancer cells determined by the ATP tumor chemosensitivity assay

Tanja Fehm, Manfred Zwirner, Diethelm Wallwiener, Harald Seeger, Hans Neubauer

Open Access Study protocol

Physiological and neurophysiological determinants of postcancer fatigue: design of a randomized controlled trial

Hetty Prinsen, Gijs Bleijenberg, Machiel J Zwarts, Maria T E Hopman, Arend Heerschap, Hanneke W M van Laarhoven

Open Access Research article

Early assessment by FDG-PET/CT of patients with advanced renal cell carcinoma treated with tyrosine kinase inhibitors is predictive of disease course

Daiki Ueno, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takayuki Murakami, Takeshi Kishida, Takeshi Miura, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

Open Access Review

Myeloid malignancies: mutations, models and management

Anne Murati, Mandy Brecqueville, Raynier Devillier, Marie-Joelle Mozziconacci, Véronique Gelsi-Boyer, Daniel Birnbaum

Open Access Research article

Overexpression of cell cycle regulator CDCA3 promotes oral cancer progression by enhancing cell proliferation with prevention of G1 phase arrest

Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hideki Tanzawa, Hiroki Bukawa

Open Access Study protocol

Design of the study: How can health care help female breast cancer patients reduce their stress symptoms? A randomized intervention study with stepped-care

Karin Nordin, Ritva Rissanen, Johan Ahlgren, Gunilla Burell, Marie-Louise Fjällskog, Susanne Börjesson, Cecilia Arving

Open Access Research article

Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma

Cardin Romilda, Piciocchi Marika, Sinigaglia Alessandro, Lavezzo Enrico, Bortolami Marina, Kotsafti Andromachi, Cillo Umberto, Zanus Giacomo, Mescoli Claudia, Rugge Massimo, Farinati Fabio

Open Access Research article

Glutathione S-transferase Pi expression predicts response to adjuvant chemotherapy for stage C colon cancer: a matched historical control study

Lucy Jankova, Graham Robertson, Charles Chan, King L Tan, Maija Kohonen-Corish, Caroline L-S Fung, Candice Clarke, Betty P C Lin, Mark Molloy, Pierre H Chapuis, Les Bokey, Owen F Dent, Stephen J Clarke

Open Access Research article

Advanced non-small cell lung cancer in patients aged 45 years or younger: outcomes and prognostic factors

Chia-Lin Hsu, Kuan-Yu Chen, Jin-Yuan Shih, Chao-Chi Ho, Chih-Hsin Yang, Chong-Jen Yu, Pan-Chyr Yang

Open Access Research article

Steroid receptor coactivators, HER-2 and HER-3 expression is stimulated by tamoxifen treatment in DMBA-induced breast cancer

Line L Haugan Moi, Marianne Hauglid Flågeng, Jennifer Gjerde, Andre Madsen, Therese Halvorsen Røst, Oddrun Anita Gudbrandsen, Ernst A Lien, Gunnar Mellgren

Open Access Case report

Atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis

Byoung Joon Baek, Jae–Min Shin, Chi Kyou Lee, Ji Hye Lee, Koen Hyeong Lee

Open Access Study protocol

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

Karsten Geletneky, Johannes Huesing, Jean Rommelaere, Joerg R Schlehofer, Barbara Leuchs, Michael Dahm, Ottheinz Krebs, Magnus von Knebel Doeberitz, Bernard Huber, Jacek Hajda

Open Access Research article

Prevalence and correlates of cancer survivors’ supportive care needs 6 months after diagnosis: a population-based cross-sectional study

Allison W Boyes, Afaf Girgis, Catherine D’Este, Alison C Zucca

Open Access Research article

Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

Ziyuan Zhou, Erich M Sturgis, Zhensheng Liu, Li-E Wang, Qingyi Wei, Guojun Li

Open Access Research article

Immunophenotyping invasive breast cancer: paving the road for molecular imaging

Jeroen F Vermeulen, Aram SA van Brussel, Petra van der Groep, Folkert HM Morsink, Peter Bult, Elsken van der Wall, Paul J van Diest

Open Access Research article

Biological characterization and selection criteria of adjuvant chemotherapy for early breast cancer: experience from the Italian observational NEMESI study

Matteo Clavarezza, Giorgio Mustacchi, Andrea Casadei Gardini, Lucia Del Mastro, Andrea De Matteis, Ferdinando Riccardi, Vincenzo Adamo, Enrico Aitini, Domenico Amoroso, Paolo Marchetti, Stefania Gori, Francesco Carrozza, Evaristo Maiello, Francesco Giotta, Davide Dondi, Marco Venturini

Open Access Research article

Menin and p53 have non-synergistic effects on tumorigenesis in mice

Kelly A Loffler, Arne W Mould, Paul M Waring, Nicholas K Hayward, Graham F Kay

Open Access Study protocol

Stereotactic ablative radiotherapy for comprehensive treatment of oligometastatic tumors (SABR-COMET): Study protocol for a randomized phase II trial

David A Palma, Cornelis J A Haasbeek, George B Rodrigues, Max Dahele, Michael Lock, Brian Yaremko, Robert Olson, Mitchell Liu, Jason Panarotto, GwendolynHMJ Griffioen, Stewart Gaede, Ben Slotman, Suresh Senan

Open Access Research article

Survival in patients with stage IV noncardia gastric cancer - the influence of DNA ploidy and Helicobacter Pyloriinfection

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Targeting of CD34+CD38-cells using Gemtuzumab ozogamicin (Mylotarg) in combination with tipifarnib (Zarnestra) in acute Myeloid Leukaemia

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Open Access Study protocol

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Caterina Iofrida, Erika Melissari, Veronica Mariotti, Chiara Guglielmi, Lucia Guidugli, Maria Adelaide Caligo, Silvia Pellegrini

Open Access Debate

Has the time to come leave the “watch-and-wait” strategy in newly diagnosed asymptomatic follicular lymphoma patients?

Antonio Rueda, María Casanova, Maximino Redondo, Elisabeth Pérez-Ruiz, Ángeles Medina-Pérez

Open Access Research article

Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia

Evgeny A Moskalev, Katrin Luckert, Ivan A Vorobjev, Sergey E Mastitsky, Aleena A Gladkikh, Achim Stephan, Marita Schrenk, Kamil D Kaplanov, Olga B Kalashnikova, Oliver Pötz, Thomas O Joos, Jörg D Hoheisel

Open Access Research article

Effectiveness of prophylactic retropharyngeal lymph node irradiation in patients with locally advanced head and neck cancer

Nam P Nguyen, Jacqueline Vock, Vincent Vinh-Hung, Fabio Almeida, Lars Ewell, Michael Betz, Siyoung Jang, Richard A Vo, Suresh Dutta, Juan Godinez, Ulf Karlsson, Alexander Chi

Open Access Research article

Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer

Seung-Hyun Jung, Ahwon Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choe, Yeun-Jun Chung

Open Access Research article

Sunitinib treatment does not improve blood supply but induces hypoxia in human melanoma xenografts

Jon-Vidar Gaustad, Trude G Simonsen, Marit N Leinaas, Einar K Rofstad

Open Access Research article

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa

Adriana C Vidal, Pauline Kay Lund, Cathrine Hoyo, Joseph Galanko, Lauren Burcal, Rachel Holston, Berri Massa, Oluwaseun Omofoye, Robert S Sandler, Temitope O Keku

Open Access Case report

Intracranial melanocytic meningeal tumours and melanosis oculi: case report and literature review

Francesco Doglietto, Cesare Colosimo, Libero Lauriola, Mario Balducci, Pasquale De Bonis, Nicola Montano, Gelareh Zadeh, Giulio Maira, Roberto Pallini

Open Access Research article

MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma

Jian Wang, Jingwu Li, Junling Shen, Chen Wang, Lili Yang, Xinwei Zhang

Open Access Research article

Risk of tobacco-related multiple primary cancers in Bavaria, Germany

Ulrike Braisch, Martin Meyer, Martin Radespiel-Tröger

Open Access Research article

Tumor response and survival in patients with advanced non-small-cell lung cancer: the predictive value of chemotherapy-induced changes in fibrinogen

Jun Zhao, Mingfang Zhao, Bo Jin, Ping Yu, Xuejun Hu, Yuee Teng, Jingdong Zhang, Ying Luo, Lingyun Zhang, Shuang Zheng, Qiyin Zhou, Heming Li, Yunpeng Liu, Xiujuan Qu

Open Access Research article

Interstitial magnetic resonance lymphography is an effective diagnostic tool for the detection of lymph node metastases in patients with cervical cancer

Ying Hong, Luojun Xiang, Yali Hu, Zhengyang Zhou, Haiping Yu, Bing Zhu

Open Access Research article

The T-box transcription factor Brachyury regulates epithelial–mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells

Miyuki Shimoda, Tsuyoshi Sugiura, Ikumi Imajyo, Kotaro Ishii, Satomi Chigita, Katsuhiro Seki, Yousuke Kobayashi, Kanemitsu Shirasuna

Open Access Research article

Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma

Shu-Cheng Zhang, Wei-Lin Wang, Wei-Song Cai, Kai-Lei Jiang, Zheng-Wei Yuan

Open Access Research article

Maintenance bevacizumab beyond first-line paclitaxel plus bevacizumab in patients with Her2-negative hormone receptor-positive metastatic breast cancer: efficacy in combination with hormonal therapy

Alessandra Fabi, Michelangelo Russillo, Gianluigi Ferretti, Giulio Metro, Cecilia Nisticò, Paola Papaldo, Ferdinando De Vita, Giuliana D’Auria, Antonello Vidiri, Diana Giannarelli, Francesco Cognetti

Open Access Research article

Lipocalin 2 expression is associated with aggressive features of endometrial cancer

Monica Mannelqvist, Ingunn M Stefansson, Elisabeth Wik, Kanthida Kusonmano, Maria B Raeder, Anne M Øyan, Karl-Henning Kalland, Marsha A Moses, Helga B Salvesen, Lars A Akslen

Open Access Research article

Cost effectivenes of erlotinib versus chemotherapy for first-line treatment of non small cell lung cancer (NSCLC) in fit elderly patients participating in a prospective phase 2 study (GFPC 0504)

Chouaid Christos, Le Caer Hervé, Locher Chrystelle, Dujon Cecile, Thomas Pascal, Auliac Jean Bernard, Monnet Isabelle, Vergnenegre Alain

Open Access Study protocol

Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer

Andreas G Niethammer, Heinz Lubenau, Gerd Mikus, Philipp Knebel, Nicolas Hohmann, Christine Leowardi, Philipp Beckhove, Mustafa Akhisaroglu, Yingzi Ge, Marco Springer, Lars Grenacher, Markus W Buchler, Moritz Koch, Jürgen Weitz, Walter E Haefeli, Friedrich H Schmitz-Winnenthal

Open Access Research article

Elevated levels of serum amyloid A indicate poor prognosis in patients with esophageal squamous cell carcinoma

Jun-Ye Wang, Yu-Zhen Zheng, Juan Yang, Yue-Hao Lin, Shu-Qin Dai, Ge Zhang, Wan-Li Liu

Open Access Research article

Knock-down of NDRG2 sensitizes cervical cancer Hela cells to cisplatin through suppressing Bcl-2 expression

Junye Liu, Le Yang, Jian Zhang, Jing Zhang, Yongbin Chen, Kangchu Li, Yurong Li, Yan Li, Libo Yao, Guozhen Guo

Open Access Research article

Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy

Harijati Versmessen, Vincent Vinh-Hung, Hilde Van Parijs, Geertje Miedema, Mia Voordeckers, Nele Adriaenssens, Guy Storme, Mark De Ridder

Open Access Research article

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer

Anna Larsson, Marie Fridberg, Alexander Gaber, Björn Nodin, Per Levéen, Göran Jönsson, Mathias Uhlén, Helgi Birgisson, Karin Jirström

Open Access Research article

Dynamic tumor modeling of the dose–response relationship for everolimus in metastatic renal cell carcinoma using data from the phase 3 RECORD-1 trial

Andrew Stein, Wenping Wang, Alison A Carter, Ovidiu Chiparus, Norbert Hollaender, Hyewon Kim, Robert J Motzer, Celine Sarr

Open Access Research article

Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study

Hiroaki Ito, Haruhiro Inoue, Norimasa Sando, Satoshi Kimura, Keigo Gohda, Jun Sato, Katsuhiro Murakami, Shun Ito, Noriko Odaka, Hitoshi Satodate, Shin-ei Kudo

Open Access Research article

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

W Jeffrey Petty, Mebea Aklilu, Victor A Varela, James Lovato, Paul D Savage, Antonius A Miller

Open Access Case report

First case of isolated vaginal metastasis from breast cancer treated by surgery

Filippo Bellati, Innocenza Palaia, Maria Luisa Gasparri, Angela Musella, Pierluigi Benedetti Panici

Open Access Research article

L-DOPA decarboxylase mRNA expression is associated with tumor stage and size in head and neck squamous cell carcinoma: a retrospective cohort study

Panagiota-Aikaterini Geomela, Christos K Kontos, Ioannis Yiotakis, Emmanuel G Fragoulis, Andreas Scorilas

Open Access Study protocol

Hypofractionated helical intensity-modulated radiotherapy of the prostate bed after prostatectomy with or without the pelvic lymph nodes - the PRIAMOS trial

Sonja Krause, Florian Sterzing, Dirk Neuhof, Lutz Edler, Juergen Debus, Klaus Herfarth

Open Access Review

Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure

Eugenio Picano, Eliseo Vano, Luciano Domenici, Matteo Bottai, Isabelle Thierry-Chef

Open Access Research article

Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress

Julie Lafontaine, Guergana Tchakarska, Francis Rodier, Anne-Marie Mes-Masson

Open Access Technical advance

Expanded clinical and experimental use of SOX11 - using a monoclonal antibody

Lena Nordström, Ulrika Andréasson, Mats Jerkeman, Michael Dictor, Carl Borrebaeck, Sara Ek

Open Access Research article

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

Fieke Lamers, Linda Schild, Jan Koster, Frank Speleman, Ingrid Øra, Ellen M Westerhout, Peter van Sluis, Rogier Versteeg, Huib N Caron, Jan J Molenaar

Open Access Study protocol

A Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma

Falk Roeder, Daniela Schulz-Ertner, Anna V Nikoghosyan, Peter E Huber, Lutz Edler, Gregor Habl, Robert Krempien, Susanne Oertel, Ladan Saleh-Ebrahimi, Frank W Hensley, Markus W Buechler, Juergen Debus, Moritz Koch, Juergen Weitz, Marc Bischof

Open Access Research article

Vaccinia virus-mediated intra-tumoral expression of matrix metalloproteinase 9 enhances oncolysis of PC-3 xenograft tumors

Simon Schäfer, Stephanie Weibel, Ulrike Donat, Qian Zhang, Richard J Aguilar, Nanhai G Chen, Aladar A Szalay

Open Access Research article

Deregulation of miR-100, miR-99a and miR-199b in tissues and plasma coexists with increased expression of mTOR kinase in endometrioid endometrial carcinoma

Anna Torres, Kamil Torres, Anna Pesci, Marcello Ceccaroni, Tomasz Paszkowski, Paola Cassandrini, Giuseppe Zamboni, Ryszard Maciejewski

Open Access Research article

High incidence of microsatellite instability and loss of heterozygosity in three loci in breast cancer patients receiving chemotherapy: a prospective study

Nasir Kamat, Mohammed A Khidhir, Mohammed Jaloudi, Sabir Hussain, Mouied M Alashari, Khaled H Al Qawasmeh, Ulf Rannug

Open Access Research article

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

Allan D Heibein, Baoqing Guo, Jason A Sprowl, David A MacLean, Amadeo M Parissenti

Open Access Research article

Loss-of-heterozygosity on chromosome 19q in early-stage serous ovarian cancer is associated with recurrent disease

Ingiridur Skirnisdottir, Markus Mayrhofer, Maria Rydåker, Helena Åkerud, Anders Isaksson

Open Access Research article

Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

Krishna B Sriram, Vandana Relan, Belinda E Clarke, Edwina E Duhig, Morgan N Windsor, Kevin S Matar, Rishendran Naidoo, Linda Passmore, Elizabeth McCaul, Deborah Courtney, Ian A Yang, Rayleen V Bowman, Kwun M Fong

Open Access Research article

A closed-tube methylation-sensitive high resolution melting assay (MS-HRMA) for the semi-quantitative determination of CST6 promoter methylation in clinical samples

Lampros Dimitrakopoulos, Panagiotis A Vorkas, Vasilis Georgoulias, Evi S Lianidou

Open Access Research article

BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors

Stephane Boeuf, Judith VMG Bovée, Burkhard Lehner, Brendy van den Akker, Maayke van Ruler, Anne-Marie Cleton-Jansen, Wiltrud Richter

Open Access Research article

LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro

Stephanie Ghislin, Dorian Obino, Sandrine Middendorp, Nicole Boggetto, Catherine Alcaide-Loridan, Frederique Deshayes

Open Access Research article

PR-104 a bioreductive pre-prodrug combined with gemcitabine or docetaxel in a phase Ib study of patients with advanced solid tumours

Mark J McKeage, Michael B Jameson, Ramesh K Ramanathan, Joseph Rajendran, Yongchuan Gu, William R Wilson, Teresa J Melink, N Simon Tchekmedyian

Open Access Research article

Different fatty acid metabolism effects of (−)-Epigallocatechin-3-Gallate and C75 in Adenocarcinoma lung cancer

Joana Relat, Adriana Blancafort, Glòria Oliveras, Sílvia Cufí, Diego Haro, Pedro F Marrero, Teresa Puig

Open Access Research article

DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a Cross-Sectional Analysis

Anne Dee, Roberta McKean-Cowdin, Marian L Neuhouser, Cornelia Ulrich, Richard N Baumgartner, Anne McTiernan, Kathy Baumgartner, Catherine M Alfano, Rachel Ballard-Barbash, Leslie Bernstein

Open Access Research article

Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine

Anke Van den broeck, Lies Gremeaux, Baki Topal, Hugo Vankelecom

Open Access Research article

Expression of ERBB3 binding protein 1 (EBP1) in salivary adenoid cystic carcinoma and its clinicopathological relevance

Jian Sun, Yixi Luo, Zhen Tian, Liang Gu, Shu Chi Xia, Youcheng Yu

Open Access Research article

Increased financial burden among patients with chronic myelogenous leukaemia receiving imatinib in Japan: a retrospective survey

Yuko Kodama, Ryoko Morozumi, Tomoko Matsumura, Yukiko Kishi, Naoko Murashige, Yuji Tanaka, Morihito Takita, Nobuyo Hatanaka, Eiji Kusumi, Masahiro Kami, Akihiko Matsui

Open Access Study protocol

Stepped care targeting psychological distress in head and neck and lung cancer patients: a randomized clinical trial

Anne-Marie H Krebber, C René Leemans, Remco de Bree, Annemieke van Straten, Filip Smit, Egbert F Smit, Annemarie Becker, Guus M Eeckhout, Aartjan TF Beekman, Pim Cuijpers, Irma M Verdonck-de Leeuw

Open Access Research article

Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition

Tobias M Gorges, Ingeborg Tinhofer, Michael Drosch, Lars Röse, Thomas M Zollner, Thomas Krahn, Oliver von Ahsen

Open Access Research article

Li-Fraumeni-like syndrome associated with a large BRCA1 intragenic deletion

Amanda Gonçalves Silva, Ingrid Petroni Ewald, Marina Sapienza, Manuela Pinheiro, Ana Peixoto, Amanda França de Nóbrega, Dirce M Carraro, Manuel R Teixeira, Patricia Ashton-Prolla, Maria Isabel W Achatz, Carla Rosenberg, Ana C V Krepischi

Open Access Research article

Options for early breast cancer follow-up in primary and secondary care - a systematic review

Frances Taggart, Peter Donnelly, Janet Dunn

Open Access Research article

Predictors of competing mortality to invasive breast cancer incidence in the Canadian National Breast Screening study

Sharareh Taghipour, Dragan Banjevic, Joanne Fernandes, Anthony B Miller, Neil Montgomery, Andrew K S Jardine, Bart J Harvey

Open Access Study protocol

Do children with central venous line (CVL) dysfunction have increased risk of symptomatic thromboembolism compared to those without CVL-dysfunction, while on cancer therapy?

Jacqueline Halton, Kim Nagel, Leonardo R Brandão, Mariana Silva, Paul Gibson, Anthony Chan, Kay Blyth, Kim Hicks, Nagina Parmar, Leslie Paddock, Stephanie Willing, Lehana Thabane, Uma Athale

Open Access Research article

A case–control study of occupation/industry and renal cell carcinoma risk

Sara Karami, Joanne S Colt, Kendra Schwartz, Faith G Davis, Julie J Ruterbusch, Stella S Munuo, Sholom Wacholder, Patricia A Stewart, Barry I Graubard, Nathanial Rothman, Wong-Ho Chow, Mark P Purdue

Open Access Research article

Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells

Massimiliano Monticone, Antonio Daga, Simona Candiani, Francesco Romeo, Valentina Mirisola, Silvia Viaggi, Ilaria Melloni, Simona Pedemonte, Gianluigi Zona, Walter Giaretti, Ulrich Pfeffer, Patrizio Castagnola

Open Access Research article

Effects of androgen deprivation on brain function in prostate cancer patients – a prospective observational cohort analysis

Herta H Chao, Edward Uchio, Sheng Zhang, Sien Hu, Sarah R Bednarski, Xi Luo, Michal Rose, John Concato, Chiang-shan R Li

Open Access Research article

A novel multiplex-protein array for serum diagnostics of colon cancer: a case–control study

Stefanie Bünger, Ulrike Haug, Maria Kelly, Nicole Posorski, Katja Klempt-Giessing, Andrew Cartwright, Stephen P Fitzgerald, Vicki Toner, Damien McAleer, Timo Gemoll, Tilman Laubert, Jürgen Büning, Klaus Fellermann, Hans-Peter Bruch, Uwe J Roblick, Hermann Brenner, Ferdinand von Eggeling, Jens K Habermann

Open Access Research article

Validation of CRP as prognostic marker for renal cell carcinoma in a large series of patients

Sandra Steffens, Astrid Köhler, Raphael Rudolph, Hendrik Eggers, Christoph Seidel, Martin Janssen, Gerd Wegener, Mark Schrader, Markus A Kuczyk, Andres J Schrader

Open Access Research article

Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway

Lili Jiang, Jueheng Wu, Yi Yang, Liping Liu, Libing Song, Jun Li, Mengfeng Li

Open Access Research article

A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study

Ran Gu, Weijuan Jia, Yunjie Zeng, Nanyan Rao, Yue Hu, Shunrong Li, Jiannan Wu, Liang Jin, Lijuan Chen, Meijun Long, Kai Chen, Lili Chen, Qiaozhen Xiao, Mei Wu, Erwei Song, Fengxi Su

Open Access Research article

Insulin-like growth factors in endometrioid adenocarcinoma: Correlation with clinico-pathological features and estrogen receptor expression

Yuan-Jiao Liang, Qun Hao, Hui-Ming Zhang, Yuan-Zhe Wu, Jian-Dong Wang

Open Access Study protocol

Online group-based cognitive-behavioural therapy for adolescents and young adults after cancer treatment: A multicenter randomised controlled trial of Recapture Life-AYA

Ursula M Sansom-Daly, Claire E Wakefield, Richard A Bryant, Phyllis Butow, Susan Sawyer, Pandora Patterson, Antoinette Anazodo, Kate Thompson, Richard J Cohn

Open Access Research article

Expression of DNA repair and replication genes in non-small cell lung cancer (NSCLC): a role for thymidylate synthetase (TYMS)

Vassiliki Kotoula, Dimitrios Krikelis, Vasilios Karavasilis, Triantafillia Koletsa, Anastasia G Eleftheraki, Despina Televantou, Christos Christodoulou, Stefanos Dimoudis, Ippokratis Korantzis, Dimitrios Pectasides, Konstantinos N Syrigos, Paris A Kosmidis, George Fountzilas

Open Access Research article

MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5

Xiang-hua Liu, Kai-hua Lu, Ke-ming Wang, Ming Sun, Er-bao Zhang, Jin-song Yang, Dan-dan Yin, Zhi-li Liu, Jing Zhou, Zhi-jun Liu, Wei De, Zhao-xia Wang

Open Access Study protocol

Treatment with bevacizumab and FOLFOXIRI in patients with advanced colorectal cancer: presentation of two novel trials (CHARTA and PERIMAX) and review of the literature

Alexander Stein, Gabriel Glockzin, Andreas Wienke, Dirk Arnold, Thomas Edelmann, Bert Hildebrandt, Stephan Hollerbach, Gerald Illerhaus, Alfred Königsrainer, Michael Richter, Hans J Schlitt, Hans-Joachim Schmoll

Open Access Research article

Correlation between Duffy blood group phenotype and breast cancer incidence

Xiao-feng Liu, Lian-fang Li, Zhou-luo Ou, Rong Shen, Zhi-min Shao

Open Access Research article

A molecular computational model improves the preoperative diagnosis of thyroid nodules

Sara Tomei, Ivo Marchetti, Katia Zavaglia, Francesca Lessi, Alessandro Apollo, Paolo Aretini, Giancarlo Di Coscio, Generoso Bevilacqua, Chiara Mazzanti

Open Access Study protocol

EXERCISE in pediatric autologous stem cell transplant patients: a randomized controlled trial protocol

Carolina Chamorro-Viña, Gregory MT Guilcher, Faisal M Khan, Karen Mazil, Fiona Schulte, Amanda Wurz, Tanya Williamson, Raylene A Reimer, S Nicole Culos-Reed

Open Access Research article

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

Antoine Italiano, Chun-Liang Chen, Yun-Shao Sung, Samuel Singer, Ronald P DeMatteo, Michael P LaQuaglia, Peter Besmer, Nicholas Socci, Cristina R Antonescu

Open Access Research article

Generation of a selectively cytotoxic fusion protein against p53 mutated cancers

Christina A Kousparou, Efthymia Yiacoumi, Mahendra P Deonarain, Agamemnon A Epenetos

Open Access Research article

Systematic review with meta-analysis of the epidemiological evidence in the 1900s relating smoking to lung cancer

Peter N Lee, Barbara A Forey, Katharine J Coombs

Open Access Research article

A comparative population-based study of prostate cancer incidence and mortality rates in Singapore, Sweden and Geneva, Switzerland from 1973 to 2006

Cynthia Chen, Nasheen Naidoo, Qian Yang, Mikael Hartman, Helena M Verkooijen, En Yun Loy, Christine Bouchardy, Kee Seng Chia, Sin Eng Chia

Open Access Research article

Beyond KRAS mutation status: influence of KRAScopy number status and microRNAs on clinical outcome to cetuximab in metastatic colorectal cancer patients

Leonie JM Mekenkamp, Jolien Tol, Jeroen R Dijkstra, Inge de Krijger, M Elisa Vink-Börger, Shannon van Vliet, Steven Teerenstra, Eveline Kamping, Eugène Verwiel, Miriam Koopman, Gerrit A Meijer, J Han JM van Krieken, Roland Kuiper, Cornelis JA Punt, Iris D Nagtegaal

Open Access Study protocol

A randomised trial of robotic and open prostatectomy in men with localised prostate cancer

Robert A Gardiner, John Yaxley, Geoff Coughlin, Nigel Dunglison, Stefano Occhipinti, Sandra Younie, Rob Carter, Scott Williams, Robyn J Medcraft, Nigel Bennett, Martin F Lavin, Suzanne Kathleen Chambers

Open Access Study protocol

Eicosapentaenoic acid (EPA) efficacy for colorectal aberrant crypt foci (ACF): a double-blind randomized controlled trial

Takuma Higurashi, Kunihiro Hosono, Hiroki Endo, Hirokazu Takahashi, Hiroshi Iida, Takashi Uchiyama, Akiko Ezuka, Shiori Uchiyama, Eiji Yamada, Hidenori Ohkubo, Eiji Sakai, Shin Maeda, Satoshi Morita, Yutaka Natsumeda, Hajime Nagase, Atsushi Nakajima

Open Access Case report

A case of lung adenocarcinoma harboring EGFR mutation and EML4-ALKfusion gene

Hisashi Tanaka, Akihito Hayashi, Takeshi Morimoto, Kageaki Taima, Yoshihito Tanaka, Michiko Shimada, Akira Kurose, Shingo Takanashi, Ken Okumura

Open Access Research article

A systematic review of the impact of stigma and nihilism on lung cancer outcomes

Suzanne K Chambers, Jeffrey Dunn, Stefano Occhipinti, Suzanne Hughes, Peter Baade, Sue Sinclair, Joanne Aitken, Pip Youl, Dianne L O’Connell

Open Access Research article

Methylseleninic acid restricts tumor growth in nude mice model of metastatic breast cancer probably via inhibiting angiopoietin-2

Xiaojing Wu, Yidi Zhang, Zengyang Pei, Si Chen, Xu Yang, Yin Chen, Degui Lin, Runlin Z Ma

Open Access Research article

Characterization of human gastric carcinoma-related methylation of 9 miR CpG islands and repression of their expressions in vitro and in vivo

Yantao Du, Zhaojun Liu, Liankun Gu, Jing Zhou, Bu-dong Zhu, Jiafu Ji, Dajun Deng

Open Access Research article

miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma

Jelena Põlajeva, Fredrik J Swartling, Yiwen Jiang, Umashankar Singh, Kristian Pietras, Lene Uhrbom, Bengt Westermark, Pernilla Roswall

Open Access Research article

Time to follow up after an abnormal finding in organized gastric cancer screening in Korea

Hoo-Yeon Lee, Kui Son Choi, Jae Kwan Jun, Myung-Il Hahm, Eun-Cheol Park

Open Access Research article

Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines

Fatima Rangwala, Kevin P Williams, Ginger R Smith, Zainab Thomas, Jennifer L Allensworth, H Kim Lyerly, Anna Mae Diehl, Michael A Morse, Gayathri R Devi

Open Access Research article

The effect of metformin and thiazolidinedione use on lung cancer in diabetics

Peter J Mazzone, Hardeep Rai, Mary Beukemann, Meng Xu, Anil Jain, Madhu Sasidhar

Open Access Research article

Postmenopausal breast cancer in Iran; risk factors and their population attributable fractions

Reza Ghiasvand, Shahram Bahmanyar, Kazem Zendehdel, Sedigheh Tahmasebi, Abdolrasoul Talei, Hans-Olov Adami, Sven Cnattingius

Open Access Case report

Blastomatoid pulmonary carcinosarcoma: report of a case with a review of the literature

Inga-Marie Schaefer, Carsten-Oliver Sahlmann, Tobias Overbeck, Stefan Schweyer, Jan Menke

Open Access Research article

A new score predicting the survival of patients with spinal cord compression from myeloma

Sarah Douglas, Steven E Schild, Dirk Rades

Open Access Research article

Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs

Laia Trigueros-Motos, Sandra Pérez-Torras, F Javier Casado, Míriam Molina-Arcas, Marçal Pastor-Anglada

Open Access Research article

Up-regulation of platelet-derived growth factor-A is responsible for the failure of re-initiated interferon alpha treatment in hepatocellular carcinoma

Ju-Bo Zhang, Hui-Chuan Sun, Wei-Dong Jia, Peng-Yuan Zhuang, Yong-Bing Qian, Xiao-Dong Zhu, Ling-Qun Kong, Lu Wang, Wei-Zhong Wu, Zhao-You Tang

Open Access Research article

Use of a chemically induced-colon carcinogenesis-prone Apc-mutant rat in a chemotherapeutic bioassay

Kazuto Yoshimi, Takao Hashimoto, Yusuke Niwa, Kazuya Hata, Tadao Serikawa, Takuji Tanaka, Takashi Kuramoto

Open Access Research article

A Phase II study of pulse dose imatinib mesylate and weekly paclitaxel in patients aged 70 and over with advanced non-small cell lung cancer

Julie E Bauman, Keith D Eaton, Sarah G Wallace, Laurie L Carr, Sang-Joon Lee, Dennie V Jones, Hugo Arias-Pulido, Lisa A Cerilli, Renato G Martins

Open Access Research article

Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α

Ceyhan Ceran, Murat Cokol, Sultan Cingoz, Ipek Tasan, Mehmet Ozturk, Tamer Yagci

Open Access Research article

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

Stephen Hiscox, Bedanta Baruah, Chris Smith, Rebecca Bellerby, Lindy Goddard, Nicola Jordan, Zaruhi Poghosyan, Robert I Nicholson, Peter Barrett-Lee, Julia Gee

Open Access Research article

Loss of aquaporin 3 protein expression constitutes an independent prognostic factor for progression-free survival: an immunohistochemical study on stage pT1 urothelial bladder cancer

Wolfgang Otto, Peter C Rubenwolf, Maximilian Burger, Hans-Martin Fritsche, Wolfgang Rößler, Matthias May, Arndt Hartmann, Ferdinand Hofstädter, Wolf F Wieland, Stefan Denzinger

Open Access Research article

Activation of AKT by hypoxia: a potential target for hypoxic tumors of the head and neck

Hanneke Stegeman, Johannes H Kaanders, Deric L Wheeler, Albert J van der Kogel, Marieke M Verheijen, Stijn J Waaijer, Mari Iida, Reidar Grénman, Paul N Span, Johan Bussink

Open Access Research article

Population-based study of breast cancer in older women: prognostic factors of relative survival and predictors of treatment

Pegdwende Olivia Dialla, Tienhan Sandrine Dabakuyo, Sophie Marilier, Julie Gentil, Patrick Roignot, Ariane Darut-Jouve, Marie-Laure Poillot, Valérie Quipourt, Patrick Arveux

Open Access Research article

Anal cytological abnormalities and epidemiological correlates among men who have sex with men at risk for HIV-1 infection

Maria Gabriella Donà, Maria Benevolo, Amina Vocaturo, Guido Palamara, Alessandra Latini, Amalia Giglio, Domenico Moretto, Francesca Rollo, Giampaolo Impara, Fabrizio Ensoli, Fulvia Pimpinelli, Aldo Di Carlo, Massimo Giuliani

Open Access Research article

Genetic polymorphisms in the osteopontin promoter increases the risk of distance metastasis and death in Chinese patients with gastric cancer

Fujun Zhao, Xiaoyi Chen, Tingting Meng, Bo Hao, Zhihong Zhang, Guoxin Zhang

Open Access Research article

Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma

Durmus Burgucu, Kenan Guney, Duygu Sahinturk, Irem Hicran Ozbudak, Deniz Ozel, Gulay Ozbilim, Ugur Yavuzer

Open Access Research article

Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine

Brian Hutzen, Christopher R Pierson, Stephen J Russell, Evanthia Galanis, Corey Raffel, Adam W Studebaker

Open Access Research article

Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells

Neka A K Simms, Ashwani Rajput, Elizabeth A Sharratt, Melanie Ongchin, Carol A Teggart, Jing Wang, Michael G Brattain

Open Access Research article

Protein markers of cancer-associated fibroblasts and tumor-initiating cells reveal subpopulations in freshly isolated ovarian cancer ascites

My Wintzell, Elisabet Hjerpe, Elisabeth Åvall Lundqvist, Maria Shoshan

Open Access Research article

Low BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival

Rui-Xue Cui, Na Liu, Qing-Mei He, Wen-Fei Li, Bi-Jun Huang, Ying Sun, Ling-Long Tang, Mo Chen, Ning Jiang, Lei Chen, Jing-Ping Yun, Jing Zeng, Ying Guo, Hui-Yun Wang, Jun Ma

Open Access Research article

Stress associated gene expression in blood cells is related to outcome in radiotherapy treated head and neck cancer patients

Siv K Bøhn, Kjell M Russnes, Amrit K Sakhi, Magne Thoresen, Marit Holden, JanØ Moskaug, Mari C Myhrstad, Ole K Olstad, Sigbjørn Smeland, Rune Blomhoff

Open Access Research article

Wnt5a promotes ewing sarcoma cell migration through upregulating CXCR4 expression

Zhe Jin, Chenghai Zhao, Xiaorui Han, Yaxin Han

Open Access Research article

Phase I study of TP300 in patients with advanced solid tumors with pharmacokinetic, pharmacogenetic and pharmacodynamic analyses

D Alan Anthoney, Jay Naik, Iain RJ MacPherson, Donna Crawford, John M Hartley, Janet A Hartley, Tomohisa Saito, Masaichi Abe, Keith Jones, Masanori Miwa, Christopher Twelves, TRJ Evans

Open Access Research article

Competitive amplification of differentially melting amplicons (CADMA) improves KRAS hotspot mutation testing in colorectal cancer

Lasse Sommer Kristensen, Tina Ellegaard Kjeldsen, Henrik Hager, Lise Lotte Hansen

Open Access Technical advance

Development of a multiplex methylation-specific PCR as candidate triage test for women with an HPV-positive cervical scrape

Suzanne Snellenberg, Lise MA De Strooper, Albertus T Hesselink, Chris JLM Meijer, Peter JF Snijders, Daniëlle AM Heideman, Renske DM Steenbergen

Open Access Research article

A retrospective study investigating the rate of HER2 discordance between primary breast carcinoma and locoregional or metastatic disease

Arlene Chan, Adrienne Morey, Belinda Brown, Diana Hastrich, Peter Willsher, David Ingram

Open Access Research article

Mode of primary cancer detection as an indicator of screening practice for second primary cancer in cancer survivors: a nationwide survey in Korea

Beomseok Suh, Dong Wook Shin, So Young Kim, Jae-Hyun Park, Weon Young Chang, Seung Pyung Lim, Chang-Yeol Yim, Be-Long Cho, Eun-Cheol Park, Jong-Hyock Park

Open Access Research article

Complement activation in astrocytomas: deposition of C4d and patient outcome

Katri Mäkelä, Pauli Helén, Hannu Haapasalo, Timo Paavonen

Open Access Research article

Expression profile and prognostic role of sex hormone receptors in gastric cancer

Lu Gan, Jian He, Xia Zhang, Yong-Jie Zhang, Guan-Zhen Yu, Ying Chen, Jun Pan, Jie-Jun Wang, Xi Wang

Open Access Study protocol

Move more for life: the protocol for a randomised efficacy trial of a tailored-print physical activity intervention for post-treatment breast cancer survivors

Camille E Short, Erica L James, Afaf Girgis, Patrick Mcelduff, Ronald C Plotnikoff

Open Access Research article

Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications

Cuilan Li, Vincent WS Liu, Pui M Chiu, David W Chan, Hextan YS Ngan

Open Access Research article

Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma

Toshihito Suda, Takanori Hama, Shu Kondo, Yuki Yuza, Mamoru Yoshikawa, Mitsuyoshi Urashima, Takakuni Kato, Hiroshi Moriyama

Open Access Research article

A systematic review of symptom assessment scales in children with cancer

L Lee Dupuis, Marie-Chantal Ethier, Deborah Tomlinson, Tanya Hesser, Lillian Sung

Open Access Research article

Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1metabolic genes and risk of lung cancer in Asturias

M Felicitas López-Cima, Sara M Álvarez-Avellón, Teresa Pascual, Ana Fernández-Somoano, Adonina Tardón

Open Access Research article

Downregulation of Cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9

Zhe Qian, Xiaoting Zhao, Mei Jiang, Wenyun Jia, Chunyan Zhang, Yue Wang, Baolan Li, Wentao Yue

Open Access Research article

Time trends of cancer mortality among elderly in Italy, 1970–2008: an observational study

Ettore Bidoli, Lucia Fratino, Silvia Bruzzone, Marilena Pappagallo, Paolo De Paoli, Umberto Tirelli, Diego Serraino

Open Access Research article

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers

Merete Bjørnslett, Stian Knappskog, Per Eystein Lønning, Anne Dørum

Open Access Research article

Deletion of the TNFAIP3/A20gene detected by FICTION analysis in classical Hodgkin lymphoma

Junko Nomoto, Nobuhiro Hiramoto, Motohiro Kato, Masashi Sanada, Akiko Miyagi Maeshima, Hirokazu Taniguchi, Fumie Hosoda, Yoshitaka Asakura, Wataru Munakata, Naohiro Sekiguchi, Dai Maruyama, Takashi Watanabe, Hitoshi Nakagama, Kengo Takeuchi, Kensei Tobinai, Seishi Ogawa, Yukio Kobayashi

Open Access Research article

Conditional survival of cancer patients: an Australian perspective

Xue Qin Yu, Peter D Baade, Dianne L O’Connell

Open Access Research article

Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours

Jochen Winter, Annette Pantelis, Dominik Kraus, Jan Reckenbeil, Rudolf Reich, Soeren Jepsen, Hans-Peter Fischer, Jean-Pierre Allam, Natalija Novak, Matthias Wenghoefer

Open Access Research article

Adherence evaluation of endocrine treatment in breast cancer: methodological aspects

Anne S Oberguggenberger, Monika Sztankay, Beate Beer, Birthe Schubert, Verena Meraner, Herbert Oberacher, Georg Kemmler, Johannes Giesinger, Eva Gamper, Barbara Sperner-Unterweger, Christian Marth, Bernhard Holzner, Michael Hubalek

Open Access Research article

Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma

Egil S Blix, Jonathan M Irish, Anne Husebekk, Jan Delabie, Lise Forfang, Anne M Tierens, June H Myklebust, Arne Kolstad

Open Access Research article

miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells

Ai-Yu Gong, Alex N Eischeid, Jing Xiao, Jian Zhao, Dongqing Chen, Zhao-Yi Wang, Charles YF Young, Xian-Ming Chen

Open Access Research article

Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines

Agnieszka Martowicz, Gilbert Spizzo, Guenther Gastl, Gerold Untergasser

Open Access Research article

Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing’s Sarcoma in vitro

Babu Jully, Ramshankar Vijayalakshmi, Gopisetty Gopal, Kesavan Sabitha, Thangarajan Rajkumar

Open Access Research article

In vitro and in vivoanti-tumor effect of metformin as a novel therapeutic agent in human oral squamous cell carcinoma

Qingqiong Luo, Dan Hu, Shuiqing Hu, Ming Yan, Zujun Sun, Fuxiang Chen

Open Access Research article

Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma

Tada Kunavisarut, Ipshita Kak, Christina MacMillan, Ranju Ralhan, Paul G Walfish

Open Access Research article

Genotype distribution of human papillomavirus (HPV) in histological sections of cervical intraepithelial neoplasia and invasive cervical carcinoma in Madrid, Spain

Benjamín García-Espinosa, Ernesto Moro-Rodríguez, Emilio Álvarez-Fernández

Open Access Research article

Aberrant expression of CD133 in non-small cell lung cancer and its relationship to vasculogenic mimicry

Shiwu Wu, Lan Yu, Danna Wang, Lei Zhou, Zenong Cheng, Damin Chai, Li Ma, Yisheng Tao

Open Access Research article

Long-term bresults of radiotherapy combined with nedaplatin and 5-fluorouracil for postoperative loco-regional recurrent esophageal cancer: update on a phase II study

Keiichi Jingu, Haruo Matsushita, Ken Takeda, Rei Umezawa, Chiaki Takahashi, Toshiyuki Sugawara, Masaki Kubozono, Keiko Abe, Takaya Tanabe, Yuko Shirata, Takaya Yamamoto, Youjirou Ishikawa, Kenji Nemoto

Open Access Research article

Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231

Arturo Aguilar-Rojas, Maira Huerta-Reyes, Guadalupe Maya-Núñez, Fabián Arechavaleta-Velásco, P Michael Conn, Alfredo Ulloa-Aguirre, Jesús Valdés

Open Access Research article

Patterns and timing of sunlight exposure and risk of basal cell and squamous cell carcinomas of the skin – a case–control study

Michelle R Iannacone, Wei Wang, Heather G Stockwell, Kathleen O’Rourke, Anna R Giuliano, Vernon K Sondak, Jane L Messina, Richard G Roetzheim, Basil S Cherpelis, Neil A Fenske, Dana E Rollison

Open Access Research article

The oncoprotein and stem cell renewal factor BMI1 associates with poor clinical outcome in oesophageal cancer patients undergoing preoperative chemoradiotherapy

Reigetsu Yoshikawa, Tohru Tsujimura, Lihua Tao, Norihiko Kamikonya, Yoshinori Fujiwara

Open Access Research article

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

Kristina Schee, Kjetil Boye, Torveig Weum Abrahamsen, Øystein Fodstad, Kjersti Flatmark

Open Access Case report

A rare case of primary clear cell sarcoma of the pubic bone resembling small round cell tumor: an unusual morphological variant

Shoko Nakayama, Taiji Yokote, Kazuki Iwaki, Toshikazu Akioka, Takuji Miyoshi, Yuji Hirata, Ayami Takayama, Uta Nishiwaki, Yuki Masuda, Motomu Tsuji, Toshiaki Hanafusa

Open Access Research article

Detection of Lipid-Rich Prostate Circulating Tumour Cells with Coherent Anti-Stokes Raman Scattering Microscopy

Ranjana Mitra, Olivia Chao, Yasuyo Urasaki, Oscar B Goodman, Thuc T Le

Open Access Study protocol

TARGIT-E(lderly)—Prospective phase II study of intraoperative radiotherapy (IORT) in elderly patients with small breast cancer

Christian Neumaier, Sperk Elena, Welzel Grit, Abo-Madyan Yasser, Kraus-Tiefenbacher Uta, Keller Anke, Gerhardt Axel, Sütterlin Marc, Wenz Frederik

Open Access Research article

TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells

Lionel Flamant, Edith Roegiers, Michael Pierre, Aurélie Hayez, Christiane Sterpin, Olivier De Backer, Thierry Arnould, Yves Poumay, Carine Michiels

Open Access Study protocol

Can exercise ameliorate treatment toxicity during the initial phase of testosterone deprivation in prostate cancer patients? Is this more effective than delayed rehabilitation?

Robert U Newton, Dennis R Taaffe, Nigel Spry, Prue Cormie, Suzanne K Chambers, Robert A Gardiner, David HK Shum, David Joseph, Daniel A Galvão

Open Access Research article

Skin toxicity and quality of life in patients with metastatic colorectal cancer during first-line panitumumab plus FOLFIRI treatment in a single-arm phase II study

Josef Thaler, Meinolf Karthaus, Laurent Mineur, Richard Greil, Henry Letocha, Ralf Hofheinz, Eva Fernebro, Erick Gamelin, Ana Baños, Claus-Henning Köhne

Open Access Research article

Multiplicative synergistic risk of hepatocellular carcinoma development among hepatitis B and C co-infected subjects in HBV endemic area: a community-based cohort study

Jin-Kyoung Oh, Hai-Rim Shin, Min Kyung Lim, Heeyoun Cho, Dong-Il Kim, Youngmee Jee, Haesun Yun, Keun-Young Yoo

Open Access Research article

Expression and significance of histone H3K27 demethylases in renal cell carcinoma

Yongqing Shen, Xiaoqiang Guo, Yuejia Wang, Wei Qiu, Yanzhong Chang, Aili Zhang, Xianglin Duan

Open Access Research article

Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkage

Fatim Lakha, Evropi Theodoratou, Susan M Farrington, Albert Tenesa, Roseanne Cetnarskyj, Farhat V N Din, Mary E Porteous, Malcolm G Dunlop, Harry Campbell

Open Access Research article

MicroRNA-99a induces G1-phase cell cycle arrest and suppresses tumorigenicity in renal cell carcinoma

Li Cui, Hua Zhou, Hu Zhao, Yaojun Zhou, Renfang Xu, Xianlin Xu, Lu Zheng, Zhong Xue, Wei Xia, Bo Zhang, Tao Ding, Yunjie Cao, Zinong Tian, Qianqian Shi, Xiaozhou He

Open Access Study protocol

Efficacy of psychodynamic short-term psychotherapy for depressed breast cancer patients: study protocol for a randomized controlled trial

Rüdiger Zwerenz, Manfred E Beutel, Barbara H Imruck, Jörg Wiltink, Antje Haselbacher, Christian Ruckes, Heinz Schmidberger, Gerald Hoffmann, Marcus Schmidt, Uwe Köhler, Dagmar Langanke, Rolf-Dieter Kortmann, Susanne Kuhnt, Gregor Weißflog, Yvette Barthel, Katja Leuteritz, Elmar Brähler

Open Access Research article

MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinase 1

Jing Liu, Kai-Hua Lu, Zhi-Li Liu, Ming Sun, Wei De, Zhao-Xia Wang

Open Access Research article

Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

Shruti U Gandhy, KyoungHyun Kim, Lesley Larsen, Rhonda J Rosengren, Stephen Safe

Open Access Study protocol

Breast ductal lavage for biomarker assessment in high risk women: rationale, design and methodology of a randomized phase II clinical trial with nimesulide, simvastatin and placebo

Matteo Lazzeroni, Aliana Guerrieri-Gonzaga, Davide Serrano, Massimiliano Cazzaniga, Serena Mora, Chiara Casadio, Costantino Jemos, Maria Pizzamiglio, Laura Cortesi, Davide Radice, Bernardo Bonanni

Open Access Research article

Impact of partial versus whole breast radiation therapy on fatigue, perceived stress, quality of life and natural killer cell activity in women with breast cancer

Kevin Albuquerque, Dina Tell, Philip Lobo, Linda Millbrandt, Herbert L Mathews, Linda Witek Janusek

Open Access Research article

Hepatitis B virus X protein suppresses caveolin-1 expression in hepatocellular carcinoma by regulating DNA methylation

Jun Yan, Qian Lu, Jiahong Dong, Xiaowu Li, Kuansheng Ma, Lei Cai

Open Access Research article

Simultaneous modulation of the intrinsic and extrinsic pathways by simvastatin in mediating prostate cancer cell apoptosis

Anna Goc, Samith T Kochuparambil, Belal Al-Husein, Ahmad Al-Azayzih, Shuaib Mohammad, Payaningal R Somanath

Open Access Research article

Prognostic significance of 5-fluorouracil metabolism-relating enzymes and enhanced chemosensitivity to 5-fluorouracil by 5-chloro 2,4-dihydroxy-pyridine in urothelial carcinoma

Hiroki Ide, Eiji Kikuchi, Masanori Hasegawa, Norihide Kozakai, Takeo Kosaka, Akira Miyajima, Mototsugu Oya

Open Access Research article

Evidence for different mechanisms of ‘unhooking’ for melphalan and cisplatin-induced DNA interstrand cross-links in vitroand in clinical acquired resistant tumour samples

Victoria J Spanswick, Helen L Lowe, Claire Newton, John P Bingham, Alessia Bagnobianchi, Konstantinos Kiakos, Charles Craddock, Jonathan A Ledermann, Daniel Hochhauser, John A Hartley

Open Access Research article

PEGylated liposome IHL-305 markedly improved the survival of ovarian cancer peritoneal metastasis in mouse

Hiroaki Konishi, Akimitsu Takagi, Akinobu Kurita, Norimasa Kaneda, Takeshi Matsuzaki

Open Access Research article

Inflammatory gene variants and the risk of biliary tract cancers and stones: a population-based study in China

Felipe A Castro, Jill Koshiol, Ann W Hsing, Yu-Tang Gao, Asif Rashid, Lisa W Chu, Ming-Chang Shen, Bing-Shen Wang, Tian-Qua Han, Bai-He Zhang, Shelley Niwa, Kai Yu, Hong Zhang, Stephen Chanock, Gabriella Andreotti

Open Access Research article

Vincristine enhances amoeboid-like motility via GEF-H1/RhoA/ROCK/Myosin light chain signaling in MKN45 cells

Masato Eitaki, Tohru Yamamori, Shunsuke Meike, Hironobu Yasui, Osamu Inanami

Open Access Research article

Increased frequency of single base substitutions in a population of transcripts expressed in cancer cells

Laurent Bianchetti, David Kieffer, Rémi Féderkeil, Olivier Poch

Open Access Research article

Serological identification of Tektin5 as a cancer/testis antigen and its immunogenicity

Tadashi Hanafusa, Ali Eldib Ali Mohamed, Shohei Domae, Eiichi Nakayama, Toshiro Ono

Open Access Study protocol

Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial

Matthias Guckenberger, Maria Hawkins, Michael Flentje, Reinhart A Sweeney

Open Access Research article

Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls

Andreas Hillenbrand, Juliane Fassler, Nadine Huber, Pengfei Xu, Doris Henne-Bruns, Markus Templin, Hubert Schrezenmeier, Anna Maria Wolf, Uwe Knippschild

Open Access Research article

Screening of Finnish RAD51Cfounder mutations in prostate and colorectal cancer patients

Liisa M Pelttari, Riikka Nurminen, Alexandra Gylfe, Lauri A Aaltonen, Johanna Schleutker, Heli Nevanlinna

Open Access Research article

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

Selena Z Kuo, Katherine J Blair, Elham Rahimy, Alan Kiang, Eric Abhold, Jian-Bing Fan, Jessica Wang-Rodriguez, Xabier Altuna, Weg M Ongkeko

Open Access Research article

Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer

Hyeong-Gon Moon, Jae Kyo Yi, Hee Sung Kim, Hea Young Lee, Kyung-Min Lee, Minju Yi, Sookyung Ahn, Hee-Chul Shin, Ji-hyun Ju, Incheol Shin, Wonshik Han, Dong-Young Noh

Open Access Research article

The role of MMP-1 in breast cancer growth and metastasis to the brain in a xenograft model

Hui Liu, Yukinari Kato, Stephanie A Erzinger, Galina M Kiriakova, Yongzhen Qian, Diane Palmieri, Patricia S Steeg, Janet E Price

Open Access Research article

Alcohol consumption and risk of gastric cancer: a cohort study of men in Kaunas, Lithuania, with up to 30 years follow-up

Ruta Everatt, Abdonas Tamosiunas, Irena Kuzmickiene, Dalia Virviciute, Ricardas Radisauskas, Regina Reklaitiene, Egle Milinaviciene

Open Access Research article

Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin

Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Katrin Orlowski, Martin Pruschy, Rolf A Stahel

Open Access Research article

Yoga for breast cancer patients and survivors: a systematic review and meta-analysis

Holger Cramer, Silke Lange, Petra Klose, Anna Paul, Gustav Dobos

Open Access Research article

Impact of modern chemotherapy on the survival of women presenting with de novo metastatic breast cancer

Sumanta K Pal, Mary Dehaven, Rebecca A Nelson, Susan Onami, JoAnn Hsu, Sarah Waliany, Laura Kruper, Joanne Mortimer

Open Access Research article

Identifying specific non-attending groups in breast cancer screening - population-based registry study of participation and socio-demography

Line Flytkjær Jensen, Anette Fischer Pedersen, Berit Andersen, Peter Vedsted

Open Access Research article

CYP1A2 rs762551 polymorphism contributes to cancer susceptibility: a meta-analysis from 19 case-control studies

Hongge Wang, Zhi Zhang, Sugui Han, Yujuan Lu, Fumin Feng, Juxiang Yuan

Open Access Research article

Let-7 miRNA-binding site polymorphism in the KRAS 3′UTR; colorectal cancer screening population prevalence and influence on clinical outcome in patients with metastatic colorectal cancer treated with 5-fluorouracil and oxaliplatin +/− cetuximab

Janne B Kjersem, Tone Ikdahl, Tormod Guren, Eva Skovlund, Halfdan Sorbye, Julian Hamfjord, Per Pfeiffer, Bengt Glimelius, Christian Kersten, Hiroko Solvang, Kjell M Tveit, Elin H Kure

Open Access Research article

PTENgenomic deletion predicts prostate cancer recurrence and is associated with low AR expression and transcriptional activity

Khalil Choucair, Joshua Ejdelman, Fadi Brimo, Armen Aprikian, Simone Chevalier, Jacques Lapointe

Open Access Research article

Association of p21 SNPs and risk of cervical cancer among Chinese women

Ning Wang, Shizhuo Wang, Qiao Zhang, Yanming Lu, Heng Wei, Wei Li, Shulan Zhang, Duo Yin, Yangling Ou

Open Access Research article

Quality indicators for colorectal cancer surgery and care according to patient-, tumor-, and hospital-related factors

Simone Mathoulin-Pélissier, Yves Bécouarn, Geneviève Belleannée, Elodie Pinon, Anne Jaffré, Gaëlle Coureau, Dominique Auby, Jean-Louis Renaud-Salis, Eric Rullier

Open Access Research article

Screening for distress, the 6th vital sign: common problems in cancer outpatients over one year in usual care: associations with marital status, sex, and age

Janine Giese-Davis, Amy Waller, Linda E Carlson, Shannon Groff, Lihong Zhong, Eric Neri, Sacha M Bachor, Jassandre Adamyk-Simpson, Kate MS Rancourt, Bernie Dunlop, Barry D Bultz

Open Access Research article

Assessing risk of breast cancer in an ethnically South-East Asia population (results of a multiple ethnic groups study)

Fei Gao, David Machin, Khuan-Yew Chow, Yu-Fan Sim, Stephen W Duffy, David B Matchar, Chien-Hui Goh, Kee-Seng Chia

Open Access Research article

Mammographic density and inter-observer variability of pathologic evaluation of core biopsies among women with mammographic abnormalities

Pietro Trocchi, Giske Ursin, Oliver Kuss, Kathrin Ruschke, Andrea Schmidt-Pokrzywniak, Hans-Jürgen Holzhausen, Thomas Löning, Christoph Thomssen, Werner Böcker, Alexander Kluttig, Andreas Stang

Open Access Research article

Expression of aurora kinase A is associated with metastasis-free survival in node-negative breast cancer patients

Wulf Siggelkow, Daniel Boehm, Susanne Gebhard, Marco Battista, Isabel Sicking, Antje Lebrecht, Christine Solbach, Birte Hellwig, Jörg Rahnenführer, Heinz Koelbl, Mathias Gehrmann, Rosemarie Marchan, Cristina Cadenas, Jan G Hengstler, Marcus Schmidt

Open Access Study protocol

Neurofeedback to improve neurocognitive functioning of children treated for a brain tumor: design of a randomized controlled double-blind trial

Marieke A de Ruiter, Antoinette YN Schouten-Van Meeteren, Rosa van Mourik, Tieme WP Janssen, Juliette EM Greidanus, Jaap Oosterlaan, Martha A Grootenhuis

Open Access Research article

The role of chemoprevention by selective cyclooxygenase-2 inhibitors in colorectal cancer patients - a population-based study

Yi-Hsin Yang, Yea-Huei Kao Yang, Ching-Lan Cheng, Pei-Shan Ho, Ying-Chin Ko

Open Access Research article

Hypofractionated stereotactic radiotherapy of limited brain metastases: a single-centre individualized treatment approach

Bettina Märtens, Stefan Janssen, Martin Werner, Jörg Frühauf, Hans Christiansen, Michael Bremer, Diana Steinmann

Open Access Research article

Herpes zoster is associated with an increased risk of subsequent lymphoid malignancies - A nationwide population-based matched-control study in Taiwan

Yi-Chang Liu, Yi-Hsin Yang, Hui-Hua Hsiao, Wen-Chi Yang, Ta-Chih Liu, Chao-Sung Chang, Ming-Yu Yang, Pai-Mei Lin, Jui-Feng Hsu, Pi-Yu Chang, Sheng-Fung Lin

Open Access Research article

PDGFRα/β and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome

Purificacion Estevez-Garcia, Angel Castaño, Ana C Martin, Fernando Lopez-Rios, Joaquin Iglesias, Sandra Muñoz-Galván, Iker Lopez-Calderero, Sonia Molina-Pinelo, Maria D Pastor, Amancio Carnero, Luis Paz-Ares, Rocio Garcia-Carbonero

Open Access Case report

Pyloric gland adenoma of the cystic duct with malignant transformation: report of a case with a review of the literature

Inga-Marie Schaefer, Silke Cameron, Peter Middel, Kia Homayounfar, Harald Schwörer, Michael Vieth, Lothar Veits

Open Access Research article

Prognostic role of CD133 expression in colorectal cancer: a meta-analysis

Ke Wang, Jianjun Xu, Junshu Zhang, Jian Huang

Open Access Research article

Designing an intervention to help people with colorectal adenomas reduce their intake of red and processed meat and increase their levels of physical activity: a qualitative study

George Dowswell, Angela Ryan, Aliki Taylor, Amanda Daley, Nick Freemantle, Matthew Brookes, Janet Jones, Richard Haslop, Chloe Grimmett, Kar-Keung Cheng, Wilson Sue

Open Access Study protocol

A nationwide study on reproductive function, ovarian reserve, and risk of premature menopause in female survivors of childhood cancer: design and methodological challenges

Annelies Overbeek, Marleen H van den Berg, Leontien CM Kremer, Marry M van den Heuvel-Eibrink, Wim JE Tissing, Jacqueline J Loonen, Birgitta Versluys, Dorine Bresters, Gertjan JL Kaspers, Cornelis B Lambalk, Flora E van Leeuwen, Eline van Dulmen-den Broeder

Open Access Research article

Derivation and characterization of matched cell lines from primary and recurrent serous ovarian cancer

Isabelle J Létourneau, Michael CJ Quinn, Lu-Lin Wang, Lise Portelance, Katia Y Caceres, Louis Cyr, Nathalie Delvoye, Liliane Meunier, Manon de Ladurantaye, Zhen Shen, Suzanna L Arcand, Patricia N Tonin, Diane M Provencher, Anne-Marie Mes-Masson

Open Access Research article

RON is not a prognostic marker for resectable pancreatic cancer

Carole M Tactacan, David K Chang, Mark J Cowley, Emily S Humphrey, Jianmin Wu, Anthony J Gill, Angela Chou, Katia Nones, Sean M Grimmond, Robert L Sutherland, Andrew V Biankin, Roger J Daly

Open Access Research article

Risk factors for nasal malignancies in German men: the South-German Nasal cancer study

Eberhard M Greiser, Karin Halina Greiser, Wolfgang Ahrens, Rudolf Hagen, Roland Lazszig, Heinz Maier, Bernhard Schick, Hans Peter Zenner

Open Access Research article

The prognostic impact of epidermal growth factor receptor in patients with metastatic gastric cancer

Akin Atmaca, Dominique Werner, Claudia Pauligk, Kristina Steinmetz, Ralph Wirtz, Hans-Michael Altmannsberger, Elke Jäger, Salah-Eddin Al-Batran

Open Access Research article

CanPrevent: a telephone-delivered intervention to reduce multiple behavioural risk factors for colorectal cancer

Anna L Hawkes, Tania A Patrao, Anita Green, Joanne F Aitken

Open Access Research article

Phase I study of imatinib, cisplatin and 5-fluoruracil or capecitabine in advanced esophageal and gastric adenocarcinoma

Martina Mayr, Karen Becker, Nadine Schulte, Sebastian Belle, Ralf Hofheinz, Annekatrin Krause, Roland M Schmid, Christoph Röcken, Matthias P Ebert

Open Access Research article

Microtubule S-glutathionylation as a potential approach for antimitotic agents

Wei Chen, Teresa Seefeldt, Alan Young, Xiaoying Zhang, Yong Zhao, John Ruffolo, Radhey S Kaushik, Xiangming Guan

Open Access Research article

Correlation between Slug transcription factor and miR-221 in MDA-MB-231 breast cancer cells

Elisabetta Lambertini, Andrea Lolli, Federica Vezzali, Letizia Penolazzi, Roberto Gambari, Roberta Piva

Open Access Technical advance

Decentral gene expression analysis: analytical validation of the Endopredict genomic multianalyte breast cancer prognosis test

Ralf Kronenwett, Kerstin Bohmann, Judith Prinzler, Bruno V Sinn, Franziska Haufe, Claudia Roth, Manuela Averdick, Tanja Ropers, Claudia Windbergs, Jan C Brase, Karsten E Weber, Karin Fisch, Berit M Müller, Marcus Schmidt, Martin Filipits, Peter Dubsky, Christoph Petry, Manfred Dietel, Carsten Denkert

Open Access Research article

Application of the Western-based adjuvant online model to Korean colon cancer patients; a single institution experience

Minkyu Jung, Geon Woo Kim, Inkyung Jung, Joong Bae Ahn, Jae Kyung Roh, Sun Young Rha, Hyun Cheol Chung, Nam Kyu Kim, Tae Il Kim, Sang Joon Shin

Open Access Research article

Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members

Sarah Pringels, Nancy Van Damme, Bram De Craene, Piet Pattyn, Wim Ceelen, Marc Peeters, Johan Grooten

Open Access Study protocol

The Alberta moving beyond breast cancer (AMBER) cohort study: a prospective study of physical activity and health-related fitness in breast cancer survivors

Kerry S Courneya, Jeff K Vallance, S Nicole Culos-Reed, Margaret L McNeely, Gordon J Bell, John R Mackey, Yutaka Yasui, Yan Yuan, Charles E Matthews, David CW Lau, Diane Cook, Christine M Friedenreich

Open Access Study protocol

The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol

Haryana M Dhillon, Hidde P van der Ploeg, Melanie L Bell, Michael Boyer, Stephen Clarke, Janette Vardy

Open Access Review

Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment

Marlies E Heuvers, Joachim G Aerts, Robin Cornelissen, Harry Groen, Henk C Hoogsteden, Joost P Hegmans

Open Access Research article

Impact of stem cell marker expression on recurrence of TACE-treated hepatocellular carcinoma post liver transplantation

Zhen Zeng, Jinyu Ren, Maura O’Neil, Jie Zhao, Brian Bridges, Josiah Cox, Bashar Abdulkarim, Timothy M Schmitt, Sean C Kumer, Steven A Weinman

Open Access Research article

Occupational exposure to asbestos and lung cancer in men: evidence from a population-based case-control study in eight Canadian provinces

Paul J Villeneuve, Marie-Élise Parent, Shelley A Harris, Kenneth C Johnson

Open Access Research article

LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer

Aika Matsunoki, Kazuyuki Kawakami, Masanori Kotake, Mami Kaneko, Hirotaka Kitamura, Akishi Ooi, Go Watanabe, Toshinari Minamoto

Open Access Research article

Normal tissue complication probability model parameter estimation for xerostomia in head and neck cancer patients based on scintigraphy and quality of life assessments

Tsair-Fwu Lee, Pei-Ju Chao, Hung-Yu Wang, Hsuan-Chih Hsu, PaoShu Chang, Wen-Cheng Chen

Open Access Research article

Reduced CYP2D6 function is associated with gefitinib-induced rash in patients with non-small cell lung cancer

Tomohiro Suzumura, Tatsuo Kimura, Shinzoh Kudoh, Kanako Umekawa, Misato Nagata, Kuniomi Matsuura, Hidenori Tanaka, Shigeki Mitsuoka, Naruo Yoshimura, Yukimi Kira, Toshiyuki Nakai, Kazuto Hirata

Open Access Research article

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

Stephany Corrêa, Renata Binato, Bárbara Du Rocher, Morgana TL Castelo-Branco, Luciana Pizzatti, Eliana Abdelhay

Open Access Research article

Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway

Katie Twigger, Victoria Roulstone, Joan Kyula, Eleni M Karapanagiotou, Konstantinos N Syrigos, Richard Morgan, Christine White, Shreerang Bhide, Gerard Nuovo, Matt Coffey, Brad Thompson, Adel Jebar, Fiona Errington, Alan A Melcher, Richard G Vile, Hardev S Pandha, Kevin J Harrington

Open Access Research article

A case–control study on the effect of Apolipoprotein E genotypes on gastric cancer risk and progression

Emma De Feo, Benedetto Simone, Roberto Persiani, Ferdinando Cananzi, Alberto Biondi, Dario Arzani, Rosarita Amore, Domenico D’Ugo, Gualtiero Ricciardi, Stefania Boccia

Open Access Research article

Testing of human papillomavirus in lung cancer and non-tumor lung tissue

Antonella Galvan, Sara Noci, Francesca Taverna, Claudia Lombardo, Silvia Franceschi, Ugo Pastorino, Tommaso A Dragani

Open Access Research article

Spatial morphological and molecular differences within solid tumors may contribute to the failure of vascular disruptive agent treatments

Linh Nguyen, Theodora Fifis, Caterina Malcontenti-Wilson, Lie Sam Chan, Patricia Nunes Luiza Costa, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi

Open Access Case report

Germline truncating-mutations in BRCA1 and MSH6 in a patient with early onset endometrial cancer

Karin Kast, Teresa M Neuhann, Heike Görgens, Kerstin Becker, Katja Keller, Barbara Klink, Daniela Aust, Wolfgang Distler, Evelin Schröck, Hans K Schackert

Open Access Research article

Profound tumor-specific Th2 bias in patients with malignant glioma

Shinji Shimato, Lisa M Maier, Richard Maier, Jeffrey N Bruce, Richard CE Anderson, David E Anderson

Open Access Research article

Alterations in epidermal growth factor receptors 1 and 2 in esophageal squamous cell carcinomas

Isabela Martins Gonzaga, Sheila Coelho Soares-Lima, Paulo Thiago Souza de Santos, Tania Cristina Moita Blanco, Bruno Souza Bianchi de Reis, Danielle Carvalho Quintella, Ivanir Martins de Oliveira, Paulo Antonio Silvestre de Faria, Cleber Dario Pinto Kruel, Nelson Adami Andreollo, Tatiana Almeida de Simão, Luis Felipe Ribeiro Pinto

Open Access Study protocol

Comparison of tai chi vs. strength training for fall prevention among female cancer survivors: study protocol for the GET FIT trial

Kerri M Winters-Stone, Fuzhong Li, Fay Horak, Shiuh-Wen Luoh, Jill A Bennett, Lillian Nail, Nathan Dieckmann

Open Access Research article

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers

Sylvia Hartmann, Claudio Agostinelli, Jürgen Diener, Claudia Döring, Stefano Fanti, Pier Luigi Zinzani, Andrea Gallamini, Lothar Bergmann, Stefano Pileri, Martin-Leo Hansmann

Open Access Research article

The clinical significance of Psoriasin for non-small cell lung cancer patients and its biological impact on lung cancer cell functions

Mu Hu, Lin Ye, Fiona Ruge, Xiuyi Zhi, Lijian Zhang, Wen G Jiang

Open Access Research article

Role of emmprin in endometrial cancer

Keiichiro Nakamura, Junichi Kodama, Atsushi Hongo, Yuji Hiramatsu

Open Access Research article

Mechanistic studies of Gemcitabine-loaded nanoplatforms in resistant pancreatic cancer cells

Anne-Laure Papa, Sudipta Basu, Poulomi Sengupta, Deboshri Banerjee, Shiladitya Sengupta, Rania Harfouche

Open Access Research article

The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition

Chander Peddaboina, Daniel Jupiter, Steven Fletcher, Jeremy L Yap, Arun Rai, Richard P Tobin, Weihua Jiang, Philip Rascoe, M Karen Newell Rogers, W Roy Smythe, Xiaobo Cao

Open Access Research article

Epidermal growth factor receptor (EGFR) mutations and expression in squamous cell carcinoma of the esophagus in central Asia

Behnoush Abedi-Ardekani, Nazir Ahmad Dar, Mohammad Muzaffar Mir, Showkat Ahmad Zargar, M Muqbool Lone, Ghyslaine Martel-Planche, Stéphanie Villar, Mounia Mounawar, Farrokh Saidi, Reza Malekzadeh, Pierre Hainaut

Open Access Research article

Development and validation of a questionnaire to assess delay in treatment for breast cancer

Karla Unger-Saldaña, Ingris Peláez-Ballestas, Claudia Infante-Castañeda

Open Access Research article

Peri-operative chemotherapy in the management of resectable colorectal cancer pulmonary metastases

Eliza A Hawkes, George Ladas, David Cunningham, Andrew G Nicholson, Katharina Wassilew, Yolanda Barbachano, Gihan Ratnayake, Sheela Rao, Ian Chau

Open Access Research article

A systems biology approach to the global analysis of transcription factors in colorectal cancer

Meeta P Pradhan, Nagendra KA Prasad, Mathew J Palakal

Open Access Research article

Calpain system protein expression in carcinomas of the pancreas, bile duct and ampulla

Sarah J Storr, Abed M Zaitoun, Arvind Arora, Lindy G Durrant, Dileep N Lobo, Srinivasan Madhusudan, Stewart G Martin

Open Access Research article

Doxorubicin-enriched, ALDHbr mouse breast cancer stem cells are treatable to oncolytic herpes simplex virus type 1

Xiufen Zhuang, Wen Zhang, Yatong Chen, Xiangping Han, Jie Li, Yu Zhang, Youhui Zhang, Shuren Zhang, Binlei Liu

Open Access Research article

“Iron-saturated” bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice

Xueying Sun, Ruohan Jiang, Aneta Przepiorski, Shiva Reddy, Kate P Palmano, Geoffrey W Krissansen

Open Access Research article

Statins and the risk of gastric cancer in diabetes patients

Jeeyun Lee, Soo Hyeon Lee, Kyu Yeon Hur, Sook Young Woo, Sun Woo Kim, Won Ki Kang

Open Access Research article

Overexpression of SERBP1 (Plasminogen activator inhibitor 1 RNA binding protein) in human breast cancer is correlated with favourable prognosis

Nuran Bektas Serce, Andreas Boesl, Irina Klaman, Sonja von Serényi, Erik Noetzel, Michael F Press, Arno Dimmler, Arndt Hartmann, Jalid Sehouli, Ruth Knuechel, Matthias W Beckmann, Peter A Fasching, Edgar Dahl

Open Access Research article

Detection methods predict differences in biology and survival in breast cancer patients

Maximino Redondo, Rafael Funez, Francisco Medina-Cano, Isabel Rodrigo, Mercedes Acebal, Teresa Tellez, M Jose Roldan, M Luisa Hortas, Ana Bellinvia, Teresa Pereda, Laia Domingo, María Morales-Suarez Varela, Maria Sala, Antonio Rueda

Open Access Research article

Molecular pathways undergoing dramatic transcriptomic changes during tumor development in the human colon

Rosalia Maglietta, Vania Cosma Liuzzi, Elisa Cattaneo, Endre Laczko, Ada Piepoli, Anna Panza, Massimo Carella, Orazio Palumbo, Teresa Staiano, Federico Buffoli, Angelo Andriulli, Giancarlo Marra, Nicola Ancona

Open Access Case report

Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association?

Enrico Erdas, Nicola Aste, Luca Pilloni, Angelo Nicolosi, Sergio Licheri, Antonello Cappai, Marco Mastinu, Filomena Cetani, Elena Pardi, Stefano Mariotti, Mariano Pomata

Open Access Research article

Survivin selective inhibitor YM155 induce apoptosis in SK-NEP-1 Wilms tumor cells

Yan-Fang Tao, Jun Lu, Xiao-Juan Du, Li-Chao Sun, Xuan Zhao, Liang Peng, Lan Cao, Pei-Fang Xiao, Li Pang, Dong Wu, Na Wang, Xing Feng, Yan-Hong Li, Jian Ni, Jian Wang, Jian Pan

Open Access Research article

α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial

Yasuto Akiyama, Chie Oshita, Akiko Kume, Akira Iizuka, Haruo Miyata, Masaru Komiyama, Tadashi Ashizawa, Mika Yagoto, Yoshiaki Abe, Koichi Mitsuya, Reiko Watanabe, Takashi Sugino, Ken Yamaguchi, Yoko Nakasu

Open Access Research article

Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer

Casina WS Kan, Michael A Hahn, Gregory B Gard, Jayne Maidens, Jung Yoon Huh, Deborah J Marsh, Viive M Howell

Open Access Research article

Case–control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis

Anna Gillio-Tos, Maria da Graça Bicalho, Valentina Fiano, Chiara Grasso, Valentina Tarallo, Laura De Marco, Morena Trevisan, MarinaBarbaradeSousa Xavier, Renata Slowik, Newton S Carvalho, Carlos A Maestri, Hadriano M Lacerda, Daniela Zugna, Lorenzo Richiardi, Franco Merletti

Open Access Research article

PCA3 noncoding RNA is involved in the control of prostate-cancer cell survival and modulates androgen receptor signaling

Luciana Bueno Ferreira, Antonio Palumbo, Kivvi Duarte de Mello, Cinthya Sternberg, Mauricio S Caetano, Felipe Leite de Oliveira, Adriana Freitas Neves, Luiz Eurico Nasciutti, Luiz Ricardo Goulart, Etel Rodrigues Pereira Gimba

Open Access Research article

Histone demethylase GASC1 - a potential prognostic and predictive marker in invasive breast cancer

Bozena Berdel, Kaisa Nieminen, Ylermi Soini, Maria Tengström, Marjo Malinen, Veli-Matti Kosma, Jorma J Palvimo, Arto Mannermaa

Open Access Research article

Salvage chemoradiotherapy after primary chemotherapy for locally advanced pancreatic cancer: a single-institution retrospective analysis

Hiroshi Mayahara, Yoshinori Ito, Chigusa Morizane, Hideki Ueno, Takuji Okusaka, Shunsuke Kondo, Naoya Murakami, Madoka Morota, Minako Sumi, Jun Itami

Open Access Research article

The clinical features of papillary thyroid cancer in Hashimoto’s thyroiditis patients from an area with a high prevalence of Hashimoto’s disease

Ling Zhang, Hui Li, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Yu Wang, Cai-ping Huang, Qiang Shen, Duan-shu Li, Yi Wu

Open Access Research article

Genetic oxidative stress variants and glioma risk in a Chinese population: a hospital-based case–control study

Peng Zhao, Lin Zhao, Peng Zou, Ailin Lu, Ning Liu, Wei Yan, Chunsheng Kang, Zhen Fu, Yongping You, Tao Jiang

Open Access Research article

Benefits of hyperthermic intraperitoneal chemotherapy for patients with serosal invasion in gastric cancer: a meta-analysis of the randomized controlled trials

Jingxu Sun, Yongxi Song, Zhenning Wang, Peng Gao, Xiaowan Chen, Yingying Xu, Jiwang Liang, Huimian Xu

Open Access Research article

Immediate in vivo target-specific cancer cell death after near infrared photoimmunotherapy

Makoto Mitsunaga, Takahito Nakajima, Kohei Sano, Gabriela Kramer-Marek, Peter L Choyke, Hisataka Kobayashi

Open Access Research article

Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors

Jia-Jie Hao, Zhi-Zhou Shi, Zhi-Xin Zhao, Yu Zhang, Ting Gong, Chun-Xiang Li, Ting Zhan, Yan Cai, Jin-Tang Dong, Song-Bin Fu, Qi-Min Zhan, Ming-Rong Wang

Open Access Research article

CHD1L Protein is overexpressed in human ovarian carcinomas and is a novel predictive biomarker for patients survival

Wei-Peng He, Juan Zhou, Mu-Yan Cai, Xiang-Shen Xiao, Yi-Ji Liao, Hsiang-Fu Kung, Xin-Yuan Guan, Dan Xie, Guo-Fen Yang

Open Access Study protocol

Exercise and nutrition for head and neck cancer patients: a patient oriented, clinic-supported randomized controlled trial

Lauren C Capozzi, Harold Lau, Raylene A Reimer, Margaret McNeely, Janine Giese-Davis, S Nicole Culos-Reed

Open Access Research article

Overexpression of Snail is associated with lymph node metastasis and poor prognosis in patients with gastric cancer

Na Ri Shin, Eun Hui Jeong, Chang In Choi, Hyun Jung Moon, Chae Hwa Kwon, In Sun Chu, Gwang Ha Kim, Tae Yong Jeon, Dae Hwan Kim, Jae Hyuk Lee, Do Youn Park

Open Access Research article

The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714predict adverse outcome for breast cancer patients

Eydis Th Gudmundsdottir, Rosa B Barkardottir, Adalgeir Arason, Haukur Gunnarsson, Laufey Th Amundadottir, Bjarni A Agnarsson, Oskar Th Johannsson, Inga Reynisdottir

Open Access Research article

Autophagy-independent enhancing effects of Beclin 1 on cytotoxicity of ovarian cancer cells mediated by proteasome inhibitors

Chuan Liu, Xu Yan, Hua-Qin Wang, Yan-Yan Gao, Juanjuan Liu, Zhenhua Hu, Dawo Liu, Jian Gao, Bei Lin

Open Access Research article

Androgen receptors and serum testosterone levels identify different subsets of postmenopausal breast cancers

Giorgio Secreto, Elisabetta Venturelli, Elisabetta Meneghini, Maria Luisa Carcangiu, Biagio Paolini, Roberto Agresti, Cristina Pellitteri, Franco Berrino, Massimo Gion, Patrizia Cogliati, Giuseppina Saragò, Andrea Micheli

Open Access Research article

External validation of the Bayesian Estimated Tools for Survival (BETS) models in patients with surgically treated skeletal metastases

Jonathan Agner Forsberg, Rikard Wedin, Henrik CF Bauer, Bjarne H Hansen, Minna Laitinen, Clement S Trovik, Johnny Ø Keller, Patrick J Boland, John H Healey

Open Access Research article

Prognostic value of stromal and epithelial periostin expression in human prostate cancer: correlation with clinical pathological features and the risk of biochemical relapse or death

Pier Vitale Nuzzo, Alessandra Rubagotti, Linda Zinoli, Francesco Ricci, Sandra Salvi, Simona Boccardo, Francesco Boccardo

Open Access Research article

Intraoperative Electron Radiation Therapy (IOERT) in the management of locally recurrent rectal cancer

Falk Roeder, Joerg-Michael Goetz, Gregor Habl, Marc Bischof, Robert Krempien, Markus W Buechler, Frank W Hensley, Peter E Huber, Juergen Weitz, Juergen Debus

Open Access Research article

Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer

Venkatakrishna Rao Jala, Brandie N Radde, Bodduluri Haribabu, Carolyn M Klinge

Open Access Research article

Aberrant methylation of the M-type phospholipase A2 receptor gene in leukemic cells

Mario Menschikowski, Uwe Platzbecker, Albert Hagelgans, Margot Vogel, Christian Thiede, Claudia Schönefeldt, Renate Lehnert, Graeme Eisenhofer, Gabriele Siegert

Open Access Research article

Dynamics of circulating endothelial cells and endothelial progenitor cells in breast cancer patients receiving cytotoxic chemotherapy

Yu-Hsuan Kuo, Ching-Hung Lin, Wen-Yi Shau, Te-Jung Chen, Shih-Hung Yang, Shu-Min Huang, Chun Hsu, Yen-Shen Lu, Ann-Lii Cheng

Open Access Research article

Overcoming Bcr-Abl T315I mutation by combination of GNF-2 and ATP competitors in an Abl-independent mechanism

Mamduh Khateb, Nili Ruimi, Hazem Khamisie, Yousef Najajreh, Afsar Mian, Anna Metodieva, Martin Ruthardt, Jamal Mahajna

Open Access Research article

Alternative dosing of dual PI3K and MEK inhibition in cancer therapy

Elina Jokinen, Niina Laurila, Jussi P Koivunen

Open Access Research article

Colon cancer molecular subtypes identified by expression profiling and associatedto stroma, mucinous type and different clinical behavior

Beatriz Perez Villamil, Alejandro Romera Lopez, Susana Hernandez Prieto, Guillermo Lopez Campos, Antonio Calles, Jose Antonio Lopez Asenjo, Julian Sanz Ortega, Cristina Fernandez Perez, Javier Sastre, Rosario Alfonso, Trinidad Caldes, Fernando Martin Sanchez, Eduardo Diaz Rubio

Open Access Research article

Identification of PADI2 as a potential breast cancer biomarker and therapeutic target

John L McElwee, Sunish Mohanan, Obi L Griffith, Heike C Breuer, Lynne J Anguish, Brian D Cherrington, Ashley M Palmer, Louise R Howe, Venkataraman Subramanian, Corey P Causey, Paul R Thompson, Joe W Gray, Scott A Coonrod

Open Access Research article

Physical and psychosocial benefits of yoga in cancer patients and survivors, a systematic review and meta-analysis of randomized controlled trials

Laurien M Buffart, Jannique GZ van Uffelen, Ingrid I Riphagen, Johannes Brug, Willem van Mechelen, Wendy J Brown, Mai JM Chinapaw

Open Access Research article

HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma

Peir-In Liang, Wei-Ming Li, Yu-Hui Wang, Ting-Feng Wu, Wen-Ren Wu, Alex C Liao, Kun-Hung Shen, Yu-Ching Wei, Chung-Hsi Hsing, Yow-Ling Shiue, Hsuan-Ying Huang, Han-Ping Hsu, Li-Tzon Chen, Ching-Yih Lin, Chein Tai, Chun-Mao Lin, Chien-Feng Li

Open Access Research article

Genetic association with overall survival of taxane-treated lung cancer patients - a genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study

Nifang Niu, Daniel J Schaid, Ryan P Abo, Krishna Kalari, Brooke L Fridley, Qiping Feng, Gregory Jenkins, Anthony Batzler, Abra G Brisbin, Julie M Cunningham, Liang Li, Zhifu Sun, Ping Yang, Liewei Wang

Open Access Research article

The association of DNA Repair with breast cancer risk in women. A comparative observational study

Jaime Matta, Miguel Echenique, Esperanza Negron, Luisa Morales, Wanda Vargas, Felipe Sánchez Gaetan, Eduardo Ramírez Lizardi, Aníbal Torres, Jose Ortiz Rosado, Guillermo Bolaños, Juan González Cruz, Joaquín Laboy, Ricardo Barnes, Santos Santiago Medina, Ángel Romero, Rosendo Martinez, Julie Dutil, Erick Suarez, Carolina Alvarez-Garriga, Manuel Bayona

Open Access Research article

Impact of organised cervical screening on cervical cancer incidence and mortality in migrant women in Australia

Nayyereh Aminisani, Bruce K Armstrong, Sam Egger, Karen Canfell

Open Access Research article

Unique perception of clinical trials by Korean cancer patients

Su Jin Lee, Lee Chun Park, Jeeyun Lee, Seonwoo Kim, Moon Ki Choi, Jung Yong Hong, Sylvia Park, Chi Hoon Maeng, Wonjin Chang, Young Saing Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park

Open Access Research article

Up-regulated expression of l-caldesmon associated with malignancy of colorectal cancer

Kyung-Hee Kim, Seung-Gu Yeo, Won Ki Kim, Dae Yong Kim, Hyun Yang Yeo, Jun Pyu Hong, Hee Jin Chang, Ji Won Park, Sun Young Kim, Byung Chang Kim, Byong Chul Yoo

Open Access Research article

Steroid hormone receptor expression in ovarian cancer: progesterone receptor B as prognostic marker for patient survival

Miriam Lenhard, Lennerová Tereza, Sabine Heublein, Nina Ditsch, Isabelle Himsl, Doris Mayr, Klaus Friese, Udo Jeschke

Open Access Case report

Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma

BP Fairfax, S Pratap, ISD Roberts, J Collier, R Kaplan, AM Meade, AW Ritchie, T Eisen, VM Macaulay, A Protheroe

Open Access Research article

Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells

Mulu Geletu, Rozanne Arulanandam, Samantha Greer, Aaron Trotman-Grant, Evangelia Tomai, Leda Raptis

Open Access Research article

The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo

Renquan Lu, Chengsheng Wu, Lin Guo, Yingchao Liu, Wei Mo, Huijie Wang, Jianbo Ding, Eric T Wong, Min Yu

Open Access Research article

Epidemiology and outcomes of previously undiagnosed diabetes in older women with breast cancer: an observational cohort study based on SEER-Medicare

Robert I Griffiths, Mark D Danese, Michelle L Gleeson, José M Valderas

Open Access Research article

Arachidonic acid and cancer risk: a systematic review of observational studies

Mai Sakai, Saki Kakutani, Chika Horikawa, Hisanori Tokuda, Hiroshi Kawashima, Hiroshi Shibata, Hitomi Okubo, Satoshi Sasaki

Open Access Research article

PTPRZ1 regulates calmodulin phosphorylation and tumor progression in small-cell lung carcinoma

Hideki Makinoshima, Genichiro Ishii, Motohiro Kojima, Satoshi Fujii, Youichi Higuchi, Takeshi Kuwata, Atsushi Ochiai

Open Access Research article

Disseminated tumor cells as selection marker and monitoring tool for secondary adjuvant treatment in early breast cancer. Descriptive results from an intervention study

Marit Synnestvedt, Elin Borgen, Erik Wist, Gro Wiedswang, Kjetil Weyde, Terje Risberg, Christian Kersten, Ingvil Mjaaland, Lise Vindi, Cecilie Schirmer, Jahn Martin Nesland, Bjørn Naume

Open Access Debate

Integrative oncology for breast cancer patients: introduction of an expert-based model

Gustav J Dobos, Petra Voiss, Ilka Schwidde, Kyung-Eun Choi, Anna Paul, Barbara Kirschbaum, Felix J Saha, Sherko Kuemmel

Open Access Research article

Mucin-1 and its relation to grade, stage and survival in ovarian carcinoma patients

Verena Engelstaedter, Sabine Heublein, Anamur Lan Schumacher, Miriam Lenhard, Helen Engelstaedter, Ulrich Andergassen, Margit Guenthner-Biller, Christina Kuhn, Brigitte Rack, Markus Kupka, Doris Mayr, Udo Jeschke

Open Access Study protocol

The STAR trial protocol: a randomised multi-stage phase II/III study of Sunitinib comparing temporary cessation with allowing continuation, at the time of maximal radiological response, in the first-line treatment of locally advanced/metastatic Renal Cancer

Fiona J Collinson, Walter M Gregory, Chris McCabe, Helen Howard, Catherine Lowe, DrBarbara Potrata, Sandy Tubeuf, Pat Hanlon, Lucy McParland, T Wah, Peter J Selby, Jenny Hewison, Julia Brown, Janet Brown

Open Access Research article

Snake venom toxin from vipera lebetina turanicainduces apoptosis of colon cancer cells via upregulation of ROS- and JNK-mediated death receptor expression

Mi Hee Park, MiRan Jo, Dohee Won, Ho Sueb Song, Sang Bae Han, Min Jong Song, Jin Tae Hong

Open Access Research article

Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial

David Pérol, Jocelyne Provençal, Anne-claire Hardy-Bessard, David Coeffic, Jean-Phillipe Jacquin, Cécile Agostini, Thomas Bachelot, Jean-Paul Guastalla, Xavier Pivot, Jean-Pierre Martin, Agathe Bajard, Isabelle Ray-Coquard

Open Access Research article

Tumor suppressor BLU inhibits proliferation of nasopharyngeal carcinoma cells by regulation of cell cycle, c-Jun N-terminal kinase and the cyclin D1 promoter

Xiangning Zhang, Hui Liu, Binbin Li, Peichun Huang, Jianyong Shao, Zhiwei He

Open Access Research article

The association between MTHFR 677C>T polymorphism and cervical cancer: evidence from a meta-analysis

Qiang Mei, Daijun Zhou, Jinyu Gao, Shu Shen, Jinlin Wu, Linna Guo, Zhiqing Liang

Open Access Study protocol

Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1)

Ulf Petrausch, Petra C Schuberth, Christian Hagedorn, Alex Soltermann, Sandra Tomaszek, Rolf Stahel, Walter Weder, Christoph Renner

Open Access Research article

Tissue Tolerable Plasma (TTP) induces apoptosis in pancreatic cancer cells in vitro and in vivo

Lars Ivo Partecke, Katja Evert, Jan Haugk, Friderike Doering, Lars Normann, Stephan Diedrich, Frank-Ulrich Weiss, Matthias Evert, Nils Olaf Huebner, Cristin Guenther, Claus Dieter Heidecke, Axel Kramer, René Bussiahn, Klaus-Dieter Weltmann, Onur Pati, Claudia Bender, Wolfram von Bernstorff

Open Access Research article

Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery

Gregory Sergeant, Rudy van Eijsden, Tania Roskams, Victor Van Duppen, Baki Topal

Open Access Research article

Neural protein gamma-synuclein interacting with androgen receptor promotes human prostate cancer progression

Junyi Chen, Li Jiao, Chuanliang Xu, Yongwei Yu, Zhensheng Zhang, Zheng Chang, Zhen Deng, Yinghao Sun

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