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BMC Cancer

Ausgabe 1/2014

Inhalt (997 Artikel)

Open Access Research article

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

Gaofeng Xiong, Lei Deng, Jieqing Zhu, Piotr G Rychahou, Ren Xu

Open Access Research article

Neoadjuvant chemotherapy in breast cancer significantly reduces number of yielded lymph nodes by axillary dissection

Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Gerta Rücker, Sebastian Mayer, Matthias Voigt, Juliane Farthmann, Severine Iborra, Marc Hirschfeld, Philipp T Meyer, Gerald Gitsch, Elmar Stickeler

Open Access Research article

Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K Chattopadhyay, Siddartha DattaGupta, Paul G Walfish, Shyam S Chauhan, Ranju Ralhan

Open Access Research article

Lymph node fine needle Cytology in the staging and follow-up of Cutaneous Lymphomas

Elena Vigliar, Immacolata Cozzolino, Marco Picardi, Anna Lucia Peluso, Laura Virginia Sosa Fernandez, Antonio Vetrani, Gerardo Botti, Fabrizio Pane, Carmine Selleri, Pio Zeppa

Open Access Research article

High-resolution 3D micro-CT imaging of breast microcalcifications: a preliminary analysis

Inneke Willekens, Elke Van de Casteele, Nico Buls, Frederik Temmermans, Bart Jansen, Rudi Deklerck, Johan de Mey

Open Access Research article

Healthy lifestyle and risk of breast cancer for indigenous and non-indigenous women in New Zealand: a case control study

Fiona McKenzie, Lis Ellison-Loschmann, Mona Jeffreys, Ridvan Firestone, Neil Pearce, Isabelle Romieu

Open Access Research article

Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAFmutations

Michaela Angelika Ihle, Jana Fassunke, Katharina König, Inga Grünewald, Max Schlaak, Nicole Kreuzberg, Lothar Tietze, Hans-Ulrich Schildhaus, Reinhard Büttner, Sabine Merkelbach-Bruse

Open Access Study protocol

Study protocol of a randomized controlled trial comparing Mindfulness-Based Stress Reduction with treatment as usual in reducing psychological distress in patients with lung cancer and their partners: the MILON study

Melanie PJ Schellekens, Desiree GM van den Hurk, Judith B Prins, Johan Molema, A Rogier T Donders, Willem H Woertman, Miep A van der Drift, Anne EM Speckens

Open Access Research article

Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer

Michael L Maitland, Matthew R Levine, Mario E Lacouture, Kristen E Wroblewski, Christine H Chung, Ilyssa O Gordon, Livia Szeto, Gail Ratko, Keyoumars Soltani, Mark F Kozloff, Philip C Hoffman, Ravi Salgia, David P Carbone, Theodore G Karrison, Everett E Vokes

Open Access Research article

Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis

Jianqiang Chen, Jianding Zhou, Jie Lu, Hua Xiong, Xueli Shi, Liang Gong

Open Access Research article

Helical intensity-modulated Radiotherapy of the Pelvic Lymph Nodes with Integrated Boost to the Prostate Bed - Initial Results of the PLATIN 3 Trial

Sonja Katayama, Gregor Habl, Kerstin Kessel, Lutz Edler, Juergen Debus, Klaus Herfarth, Florian Sterzing

Open Access Study protocol

Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum-sensitive epithelial ovarian cancer (SOCceR trial): a multicenter randomised controlled study

Rafli van de Laar, Petra LM Zusterzeel, Toon Van Gorp, Marrije R Buist, Willemien J van Driel, Katja N Gaarenstroom, Henriette JG Arts, Johannes CM van Huisseling, Ralph HM Hermans, Johanna MA Pijnenborg, Eltjo MJ Schutter, Harold MP Pelikan, Jos HA Vollebergh, Mirjam JA Engelen, Joanna IntHout, Roy FPM Kruitwagen, Leon FAG Massuger

Open Access Research article

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

Rajesh Thangapazham, Francisco Saenz, Shilpa Katta, Ahmed A Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava, Albert Dobi

Open Access Research article

Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke

Matthew North, Joe Shuga, Michele Fromowitz, Alexandre Loguinov, Kevin Shannon, Luoping Zhang, Martyn T Smith, Chris D Vulpe

Open Access Research article

Overexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma

Adeodat Ilboudo, Jean-Charles Nault, Hélène Dubois-Pot-Schneider, Anne Corlu, Jessica Zucman-Rossi, Michel Samson, Jacques Le Seyec

Open Access Research article

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

Amy V Paschall, Mary A Zimmerman, Christina M Torres, Dafeng Yang, May R Chen, Xia Li, Erhard Bieberich, Aiping Bai, Jacek Bielawski, Alicja Bielawska, Kebin Liu

Open Access Research article

Combination of expression levels of miR-21 and miR-126 is associated with cancer-specific survival in clear-cell renal cell carcinoma

Daniel Vergho, Susanne Kneitz, Andreas Rosenwald, Charlotte Scherer, Martin Spahn, Maximilian Burger, Hubertus Riedmiller, Burkhard Kneitz

Open Access Research article

Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case–control study in the multiethnic cohort study

Yeonju Kim, Adrian A Franke, Yurii B Shvetsov, Lynne R Wilkens, Robert V Cooney, Galina Lurie, Gertraud Maskarinec, Brenda Y Hernandez, Loïc Le Marchand, Brian E Henderson, Laurence N Kolonel, Marc T Goodman

Open Access Study protocol

The efficacy of a standardized questionnaire in facilitating personalized communication about problems encountered in cancer genetic counseling: design of a randomized controlled trial

Willem Eijzenga, Neil K Aaronson, Irma Kluijt, Grace N Sidharta, Daniela EE Hahn, Margreet GEM Ausems, Eveline MA Bleiker

Open Access Research article

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma

Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang, Dong Wang

Open Access Research article

Risks of postoperative paresis in motor eloquently and non-eloquently located brain metastases

Thomas Obermueller, Michael Schaeffner, Julia Gerhardt, Bernhard Meyer, Florian Ringel, Sandro M Krieg

Open Access Research article

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja, Magnus Essand

Open Access Research article

Progression-free survival at 2 years is a reliable surrogate marker for the 5-year survival rate in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy

Hiroaki Akamatsu, Keita Mori, Tateaki Naito, Hisao Imai, Akira Ono, Takehito Shukuya, Tetsuhiko Taira, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi, Nobuyuki Yamamoto

Open Access Research article

The novel IGF-IR/Akt–dependent anticancer activities of glucosamine

Ki-Hoon Song, Ju-Hee Kang, Jong-Kyu Woo, Jeong-Seok Nam, Hye-Young Min, Ho-Young Lee, Soo-Youl Kim, Seung-Hyun Oh

Open Access Research article

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells

Kang-Sik Seo, Jong-Seok Kim, Ji-Hoon Park, Kyoung-Sub Song, Eun-Jin Yun, Jong-Il Park, Gi Ryang Kweon, Wan-Hee Yoon, Kyu Lim, Byung-Doo Hwang

Open Access Research article

Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells

Harris Wang, The Vo, Ali Hajar, Sarah Li, Xinmei Chen, Amadeo M Parissenti, David N Brindley, Zhixiang Wang

Open Access Research article

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells

Jian Kang, C Marcelo Sergio, Robert L Sutherland, Elizabeth A Musgrove

Open Access Research article

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3

Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A Powell, David G Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G Hawkins, Dirk Spitzer

Open Access Research article

Is [F-18]-fluorodeoxy-D-glucose positron emission tomography of value in the management of patients with craniofacial bone sarcomas undergoing neo-adjuvant treatment?

Anna Maria Frezza, Tim Beale, Jamshed Bomanji, Amrita Jay, Nicholas Kalavrezos, Palma Dileo, Jeremy Whelan, Sandra J Strauss

Open Access Research article

Influence of pain severity on the quality of life in patients with head and neck cancer before antineoplastic therapy

Karine G Oliveira, Sandra V von Zeidler, Jose RV Podestá, Agenor Sena, Evandro D Souza, Jeferson Lenzi, Nazaré S Bissoli, Sonia A Gouvea

Open Access Research article

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model – role of tumor stroma cells

Katharina Leithner, Christoph Wohlkoenig, Elvira Stacher, Jörg Lindenmann, Nicole A Hofmann, Birgit Gallé, Christian Guelly, Franz Quehenberger, Philipp Stiegler, Freyja-Maria Smolle-Jüttner, Sjaak Philipsen, Helmut H Popper, Andelko Hrzenjak, Andrea Olschewski, Horst Olschewski

Open Access Research article

High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin

Frank Tacke, Oliver Galm, Nicolas Kanig, Eray Yagmur, Sabine Brandt, Jonathan A Lindquist, Christiane S Eberhardt, Ute Raffetseder, Peter R Mertens

Open Access Research article

A comprehensive look at transcription factor gene expression changes in colorectal adenomas

Janine Vonlanthen, Michal J Okoniewski, Mirco Menigatti, Elisa Cattaneo, Daniela Pellegrini-Ochsner, Ritva Haider, Josef Jiricny, Teresa Staiano, Federico Buffoli, Giancarlo Marra

Open Access Reviewer acknowledgement

Reviewer acknowledgement 2013

Dafne Solera

Open Access Research article

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

Raymond Javan Chan, Joan Webster, Bryan Chung, Louise Marquart, Muhtashimuddin Ahmed, Stuart Garantziotis

Open Access Research article

Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis

Zhigang Zhang, Chao Ni, Wuzhen Chen, Ping Wu, Zhen Wang, Junhua Yin, Jian Huang, Fuming Qiu

Open Access Research article

Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

Kelly A Avery-Kiejda, Stephen G Braye, Andrea Mathe, John F Forbes, Rodney J Scott

Open Access Research article

Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

Xuejuan Jiang, Chiu-Chen Tseng, Leslie Bernstein, Anna H Wu

Open Access Research article

Are we missing the Institute of Medicine’s mark? A systematic review of patient-reported outcome measures assessing quality of patient-centred cancer care

Flora Tzelepis, Shiho K Rose, Robert W Sanson-Fisher, Tara Clinton-McHarg, Mariko L Carey, Christine L Paul

Open Access Research article

Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma

Minhui Xu, Feng Xie, Guangyang Qian, Yingying Jing, Shanshan Zhang, Lu Gao, Tao Zheng, Mengchao Wu, Jiamei Yang, Lixin Wei

Open Access Research article

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis

Xianpeng Liu, Xin Gu, Limin Sun, Ashley B Flowers, Alfred W Rademaker, Yiran Zhou, Hiroaki Kiyokawa

Open Access Research article

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Yanlan Chai, Tao Wang, Juan Wang, Yunyi Yang, Ying Gao, Jiyong Gao, Shangfeng Gao, Yueling Wang, Xi Zhou, Zi Liu

Open Access Research article

Microvascular invasion (MVI) is a poorer prognostic predictor for small hepatocellular carcinoma

Min Du, Lingli Chen, Jing Zhao, Feng Tian, Haiying Zeng, Yunshan Tan, Huichuan Sun, Jian Zhou, Yuan Ji

Open Access Research article

A longitudinal analysis of patient satisfaction with care and quality of life in ambulatory oncology based on the OUT-PATSAT35 questionnaire

Thanh Vân France Nguyen, Amélie Anota, Anne Brédart, Alain Monnier, Jean-François Bosset, Mariette Mercier

Open Access Research article

RETRACTED ARTICLE: Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng

Open Access Research article

Acute toxicity of definitive chemoradiation in patients with inoperable or irresectable esophageal carcinoma

Nadia Haj Mohammad, Maarten CCM Hulshof, Jacques JGHM Bergman, Debby Geijsen, Johanna W Wilmink, Mark I van Berge Henegouwen, Hanneke WM van Laarhoven

Open Access Research article

A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients

Susanne Blank, Sivaramakrishna Rachakonda, Gisela Keller, Wilko Weichert, Florian Lordick, Rupert Langer, Christoph Springfeld, Thomas Bruckner, Karen Becker, Rajiv Kumar, Katja Ott

Open Access Research article

ESR1gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients

Joaquina Martínez-Galán, Blanca Torres-Torres, María Isabel Núñez, Jesús López-Peñalver, Rosario Del Moral, José Mariano Ruiz De Almodóvar, Salomón Menjón, Ángel Concha, Clara Chamorro, Sandra Ríos, Juan Ramón Delgado

Open Access Research article

Bithionol inhibits ovarian cancer cell growth In Vitro- studies on mechanism(s) of action

Vijayalakshmi N Ayyagari, Laurent Brard

Open Access Research article

Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma

Marion Fehlker, Matthew R Huska, Thomas Jöns, Miguel A Andrade-Navarro, Wolfgang Kemmner

Open Access Case report

A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer

Laura Maria Pradella, Cecilia Evangelisti, Claudia Ligorio, Claudio Ceccarelli, Iria Neri, Roberta Zuntini, Laura Benedetta Amato, Simona Ferrari, Alberto Maria Martelli, Giuseppe Gasparre, Daniela Turchetti

Open Access Research article

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells

Christin Kretzschmar, Catrin Roolf, Tina-Susann Langhammer, Anett Sekora, Anahit Pews-Davtyan, Matthias Beller, Moritz J Frech, Christian Eisenlöffel, Arndt Rolfs, Christian Junghanss

Open Access Research article

Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress

Mineaki Goto, Hiroshi Miwa, Kazuto Suganuma, Norikazu Tsunekawa-Imai, Masato Shikami, Motonori Mizutani, Shohei Mizuno, Ichiro Hanamura, Masakazu Nitta

Open Access Research article

Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs

Kati Erdmann, Knut Kaulke, Cathleen Thomae, Doreen Huebner, Mildred Sergon, Michael Froehner, Manfred P Wirth, Susanne Fuessel

Open Access Research article

A panel of genes methylated with high frequency in colorectal cancer

Susan M Mitchell, Jason P Ross, Horace R Drew, Thu Ho, Glenn S Brown, Neil FW Saunders, Konsta R Duesing, Michael J Buckley, Rob Dunne, Iain Beetson, Keith N Rand, Aidan McEvoy, Melissa L Thomas, Rohan T Baker, David A Wattchow, Graeme P Young, Trevor J Lockett, Susanne K Pedersen, Lawrence C LaPointe, Peter L Molloy

Open Access Research article

Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)

Kristina Lindemann, Susanne Malander, Rene D Christensen, Mansoor R Mirza, Gunnar B Kristensen, Elisabeth Aavall-Lundqvist, Ignace Vergote, Per Rosenberg, Karin Boman, Britta Nordstrøm

Open Access Research article

Microvascular density of regenerative nodule to small hepatocellular carcinoma by automated analysis using CD105 and CD34 immunoexpression

Juliana Passos Paschoal, Vagner Bernardo, Nathalie Henriques Silva Canedo, Osmar Damasceno Ribeiro, Adriana Caroli-Bottino, Vera Lucia Pannain

Open Access Research article

Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer

Christopher A McGoldrick, Yu-Lin Jiang, Victor Paromov, Marianne Brannon, Koyamangalath Krishnan, William L Stone

Open Access Research article

Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial

Harald Rief, Georg Omlor, Michael Akbar, Thomas Welzel, Thomas Bruckner, Stefan Rieken, Matthias F Haefner, Ingmar Schlampp, Alexandros Gioules, Daniel Habermehl, Friedbert von Nettelbladt, Jürgen Debus

Open Access Research article

MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell

Yuhua Lu, Jingjing Lu, Xiaohong Li, Hui Zhu, Xiangjun Fan, Shajun Zhu, Yao Wang, Qingsong Guo, Lei Wang, Yan Huang, Mingyan Zhu, Zhiwei Wang

Open Access Research article

MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells

Yu Zhao, Jie Huang, Li Zhang, Ying Qu, Jianfang Li, Beiqin Yu, Min Yan, Yingyan Yu, Bingya Liu, Zhenggang Zhu

Open Access Research article

FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer

Meiting Qiu, Wei Bao, Jingyun Wang, Tingting Yang, Xiaoying He, Yun Liao, Xiaoping Wan

Open Access Research article

A new technique combining virtual simulation and methylene blue staining for the localization of small peripheral pulmonary lesions

Yang Shentu, Liang Zhang, Hengle Gu, Feng Mao, Minghui Cai, Zhengping Ding, Zhiqiang Wang

Open Access Research article

TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

Susann Voigt, Stephan Philipp, Parvin Davarnia, Supandi Winoto-Morbach, Christian Röder, Christoph Arenz, Anna Trauzold, Dieter Kabelitz, Stefan Schütze, Holger Kalthoff, Dieter Adam

Open Access Research article

Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker

Bente Vilming Elgaaen, Ole Kristoffer Olstad, Kari Bente Foss Haug, Berit Brusletto, Leiv Sandvik, Anne Cathrine Staff, Kaare M Gautvik, Ben Davidson

Open Access Study protocol

My Road Ahead study protocol: a randomised controlled trial of an online psychological intervention for men following treatment for localised prostate cancer

Addie C Wootten, Jo-Anne M Abbott, Katherine E Chisholm, David W Austin, Britt Klein, Marita P McCabe, Denny Meyer, Anthony J Costello, Declan G Murphy

Open Access Research article

Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Zhihong Chen, Lora W Forman, Robert M Williams, Douglas V Faller

Open Access Research article

The effect of patient characteristics on second primary cancer risk in France

Jérémie Jégu, Marc Colonna, Laetitia Daubisse-Marliac, Brigitte Trétarre, Olivier Ganry, Anne-Valérie Guizard, Simona Bara, Xavier Troussard, Véronique Bouvier, Anne-Sophie Woronoff, Michel Velten

Open Access Research article

Approaches for classifying the indications for colonoscopy using detailed clinical data

Hirut Fassil, Kenneth F Adams, Sheila Weinmann, V Paul Doria-Rose, Eric Johnson, Andrew E Williams, Douglas A Corley, Chyke A Doubeni

Open Access Research article

Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics

Jiří Mayer, Christopher Arthur, Jacques Delaunay, Grzegorz Mazur, Xavier G Thomas, Agnieszka Wierzbowska, Farhad Ravandi, Erhan Berrak, Mark Jones, Yuhan Li, Hagop M Kantarjian

Open Access Research article

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger, Helmut Klocker

Open Access Research article

Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer

Makito Miyake, Adrienne Lawton, Yunfeng Dai, Myron Chang, Lourdes Mengual, Antonio Alcaraz, Steve Goodison, Charles J Rosser

Open Access Research article

Socioeconomic environment and cancer incidence: a French population-based study in Normandy

Josephine Bryere, Olivier Dejardin, Veronique Bouvier, Marc Colonna, Anne-Valérie Guizard, Xavier Troussard, Carole Pornet, Françoise Galateau-Salle, Simona Bara, Ludivine Launay, Lydia Guittet, Guy Launoy

Open Access Research article

DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts

Tord Hompland, Christine Ellingsen, Kanthi Galappathi, Einar K Rofstad

Open Access Research article

Up-regulated MicroRNA-181a induces carcinogenesis in Hepatitis B virus-related hepatocellular carcinoma by targeting E2F5

Chengcheng Zou, Yongguo Li, Yiyi Cao, Jinnan Zhang, Jingrong Jiang, Yanrui Sheng, Sen Wang, Ailong Huang, Hua Tang

Open Access Research article

Regulation of Mcl-1 by constitutive activation of NF-kappaB contributes to cell viability in human esophageal squamous cell carcinoma cells

Haidan Liu, Jinfu Yang, Yunchang Yuan, Zhenkun Xia, Mingjiu Chen, Li Xie, Xiaolong Ma, Jian Wang, Sufeng Ouyang, Qin Wu, Fenglei Yu, Xinmin Zhou, Yifeng Yang, Ya Cao, Jianguo Hu, Bangliang Yin

Open Access Research article

Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project

Björn Lindkvist, Dorthe Johansen, Tanja Stocks, Hans Concin, Tone Bjørge, Martin Almquist, Christel Häggström, Anders Engeland, Göran Hallmans, Gabriele Nagel, Håkan Jonsson, Randi Selmer, Hanno Ulmer, Steinar Tretli, Pär Stattin, Jonas Manjer

Open Access Research article

A genomics approach to identify susceptibilities of breast cancer cells to “fever-range” hyperthermia

Clarissa Amaya, Vittal Kurisetty, Jessica Stiles, Alice M Nyakeriga, Arunkumar Arumugam, Rajkumar Lakshmanaswamy, Cristian E Botez, Dianne C Mitchell, Brad A Bryan

Open Access Research article

The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells

Jing Wang, Xiao-Hong Liu, Zi-Jian Yang, Bing Xie, Yi-Sheng Zhong

Open Access Research article

Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining

Ranjana Mitra, Oscar B Goodman, Thuc T Le

Open Access Research article

Decreased GATA5 mRNA expression associates with CpG island methylation and shortened recurrence-free survival in clear cell renal cell carcinoma

Inga Peters, Natalia Dubrowinskaja, Michael Kogosov, Mahmoud Abbas, Jörg Hennenlotter, Christoph von Klot, Axel S Merseburger, Arnulf Stenzl, Ralph Scherer, Markus A Kuczyk, Jürgen Serth

Open Access Research article

The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management

Luca Faloppi, Mario Scartozzi, Maristella Bianconi, Gianluca Svegliati Baroni, Pierluigi Toniutto, Riccardo Giampieri, Michela Del Prete, Samuele De Minicis, Davide Bitetto, Cristian Loretelli, Marco D’Anzeo, Antonio Benedetti, Stefano Cascinu

Open Access Research article

Overexpression of miR-9 in mast cells is associated with invasive behavior and spontaneous metastasis

Joelle M Fenger, Misty D Bear, Stefano Volinia, Tzu-Yin Lin, Bonnie K Harrington, Cheryl A London, William C Kisseberth

Open Access Research article

Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells – a preclinical MR study in mice

Claudia Weidensteiner, Peter R Allegrini, Melanie Sticker-Jantscheff, Vincent Romanet, Stephane Ferretti, Paul MJ McSheehy

Open Access Research article

The epidemiology of gastrointestinal stromal tumors in Taiwan, 1998–2008: a nation-wide cancer registry-based study

Nai-Jung Chiang, Li-Tzong Chen, Chia-Rung Tsai, Jeffrey S Chang

Open Access Research article

A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG)

George Pentheroudakis, Vassiliki Kotoula, Elena Fountzilas, George Kouvatseas, George Basdanis, Ioannis Xanthakis, Thomas Makatsoris, Elpida Charalambous, Demetris Papamichael, Epaminontas Samantas, Pavlos Papakostas, Dimitrios Bafaloukos, Evangelia Razis, Christos Christodoulou, Ioannis Varthalitis, Nicholas Pavlidis, George Fountzilas

Open Access Research article

Strategies and opportunities to STOP colon cancer in priority populations: pragmatic pilot study design and outcomes

Gloria D Coronado, William M Vollmer, Amanda Petrik, Josue Aguirre, Tanya Kapka, Jennifer DeVoe, Jon Puro, Tran Miers, Jennifer Lembach, Ann Turner, Jennifer Sanchez, Sally Retecki, Christine Nelson, Beverly Green

Open Access Research article

FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients

Peter A Fasching, Sebastian M Jud, Maik Hauschild, Sherko Kümmel, Martin Schütte, Matthias Warm, Volker Hanf, Dieter Grab, Jutta Krocker, Elmar Stickeler, Rolf Kreienberg, Thomas Müller, Thorsten Kühn, Christopher Wolf, Steffen Kahlert, Stefan Paepke, Michael Berghorn, Mathias Muth, Monika Baier, Birgit Wackwitz, Rüdiger Schulz-Wendtland, Matthias W Beckmann, Michael P Lux

Open Access Research article

PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer

Jiao Liu, Chui-ze Kong, Da-xin Gong, Zhe Zhang, Yu-yan Zhu

Open Access Research article

Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas

Ksenia A Arkhipova, Anastasia N Sheyderman, Konstantin K Laktionov, Valeria V Mochalnikova, Irina B Zborovskaya

Open Access Study protocol

Epidemiological study of prostate cancer (EPICAP): a population-based case–control study in France

Florence Menegaux, Antoinette Anger, Hasina Randrianasolo, Claire Mulot, Pierre Laurent-Puig, François Iborra, Jean-Pierre Bringer, Benoit Leizour, Rodolphe Thuret, Pierre-Jean Lamy, Xavier Rébillard, Brigitte Trétarre

Open Access Research article

Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin

Chen-Chieh Yang, Shun-Fu Chang, Jian-Kang Chao, Yi-Liang Lai, Wei-En Chang, Wen-Hsiu Hsu, Wu-Hsien Kuo

Open Access Research article

Human papillomavirus prevalence and type-distribution in women with cervical lesions: a cross-sectional study in Sri Lanka

Kanishka Karunaratne, Himali Ihalagama, Saman Rohitha, Anco Molijn, Kusuma Gopala, Johannes E Schmidt, Jing Chen, Sanjoy Datta, Shailesh Mehta

Open Access Research article

Wnt modulates MCL1 to control cell survival in triple negative breast cancer

Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann, Yun Yen

Open Access Research article

Molecular characterization of exosome-like vesicles from breast cancer cells

Stefan Kruger, Zakaria Y Abd Elmageed, David H Hawke, Philipp M Wörner, David A Jansen, Asim B Abdel-Mageed, Eckhard U Alt, Reza Izadpanah

Open Access Research article

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

Sophie Lehn, Nicholas P Tobin, Andrew H Sims, Olle Stål, Karin Jirström, Håkan Axelson, Göran Landberg

Open Access Research article

Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer

Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang, Hee-Na Kim

Open Access Research article

A pilot study of FDG PET/CT detects a link between brown adipose tissue and breast cancer

Qi Cao, Jerome Hersl, Hongloan La, Mark Smith, Jason Jenkins, Olga Goloubeva, Vasken Dilsizian, Katherine Tkaczuk, Wengen Chen, Laundette Jones

Open Access Research article

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice

Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao, Wei Xiong

Open Access Research article

Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications

Huali Wang, Haijing Liu, Xin Li, Jing Zhao, Hong Zhang, Jingzhuo Mao, Yongxin Zou, Hong Zhang, Shuang Zhang, Wei Hou, Lin Hou, Michael A McNutt, Bo Zhang

Open Access Study protocol

Colorectal cancer stage at diagnosis in migrants versus non-migrants (KoMigra): study protocol of a cross-sectional study in Germany

Anne Dahlhaus, Corina Guethlin, Arthur Schall, Maja Taubenroth, Reyn van Ewijk, Hajo Zeeb, Zeycan Albay, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Maria Blettner, Andrea Siebenhofer

Open Access Research article

Can we accurately report PTEN status in advanced colorectal cancer?

Christopher Hocking, Jennifer E Hardingham, Vy Broadbridge, Joe Wrin, Amanda R Townsend, Niall Tebbutt, John Cooper, Andrew Ruszkiewicz, Chee Lee, Timothy J Price

Open Access Research article

Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors

Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin, Johan Bussink

Open Access Research article

Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study

Yulan Ren, Boer Shan, Daren Shi, Huaying Wang

Open Access Research article

Analysis of the impact of platinum-based combination chemotherapy in small cell cervical carcinoma: a multicenter retrospective study in Chinese patients

Long Huang, Ling-Min Liao, An-Wen Liu, Jian-Bing Wu, Xiao-Ling Cheng, Jia-Xin Lin, Min Zheng

Open Access Research article

Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

Ekta Agarwal, Anathbandhu Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain, Sanjib Chowdhury

Open Access Research article

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

Kimberly C Wiegand, Bryan T Hennessy, Samuel Leung, Yemin Wang, Zhenlin Ju, Mollianne McGahren, Steve E Kalloger, Sarah Finlayson, Katherine Stemke-Hale, Yiling Lu, Fan Zhang, Michael S Anglesio, Blake Gilks, Gordon B Mills, David G Huntsman, Mark S Carey

Open Access Research article

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang, Basil Rigas

Open Access Research article

Intracellular coexpression of CXC- and CC– chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation

Sandra Pinto, Alicia Martínez-Romero, José-Enrique O’Connor, Rosario Gil-Benso, Teresa San-Miguel, Liria Terrádez, Carlos Monteagudo, Robert C Callaghan

Open Access Research article

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida

Open Access Research article

Primary tumor regression speed after radiotherapy and its prognostic significance in nasopharyngeal carcinoma: a retrospective study

Ning Zhang, Shao-Bo Liang, Yan-Ming Deng, Rui-Liang Lu, Hai-Yang Chen, Hai Zhao, Zhi-Qian Lv, Shao-Qiang Liang, Lin Yang, Dong-Sheng Liu, Yong Chen

Open Access Research article

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli, Katia Scotlandi

Open Access Research article

Age and stage at diagnosis: a hospital series of 11 women with intellectual disability and breast carcinoma

Daniel Satgé, Eric-André Sauleau, William Jacot, Fernand Raffi, Bernard Azéma, Jean-Claude Bouyat, Nicolas El Hage Assaf

Open Access Research article

ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

Mariana Emerenciano, Thayana Conceição Barbosa, Bruno Almeida Lopes, Caroline Barbieri Blunck, Alessandra Faro, Camilla Andrade, Claus Meyer, Rolf Marschalek, Maria S Pombo-de-Oliveira

Open Access Research article

RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira, Maria S Pombo-de-Oliveira

Open Access Research article

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

Patrizia Sanità, Mattia Capulli, Anna Teti, Giuseppe Paradiso Galatioto, Carlo Vicentini, Paola Chiarugi, Mauro Bologna, Adriano Angelucci

Open Access Technical advance

Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens

Torsten Nielsen, Brett Wallden, Carl Schaper, Sean Ferree, Shuzhen Liu, Dongxia Gao, Garrett Barry, Naeem Dowidar, Malini Maysuria, James Storhoff

Open Access Research article

Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes

Min Zhang, Yang D Chai, Jeffrey Brumbaugh, Xiaojun Liu, Ramin Rabii, Sizhe Feng, Kaori Misuno, Diana Messadi, Shen Hu

Open Access Research article

Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach

Nancy Santos-Martínez, Lorenza Díaz, David Ordaz-Rosado, Janice García-Quiroz, David Barrera, Euclides Avila, Ali Halhali, Heriberto Medina-Franco, María J Ibarra-Sánchez, José Esparza-López, Javier Camacho, Fernando Larrea, Rocío García-Becerra

Open Access Study protocol

Prospective study of high-risk, BRCA1/2-mutation negative women: the ‘negative study’

Joanne Kotsopoulos, Kelly Metcalfe, Jill Alston, Dina Nikitina, Ophira Ginsburg, Andrea Eisen, Rochelle Demsky, Mohammad Akbari, Kevin Zbuk, Steven A Narod

Open Access Research article

Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway

Ting Li, Qunling Zhang, Jian Zhang, Gong Yang, Zhimin Shao, Jianmin Luo, Minhao Fan, Chen Ni, Zhenhua Wu, Xichun Hu

Open Access Research article

Endothelial cell-derived interleukin-6 regulates tumor growth

Kathleen G Neiva, Kristy A Warner, Marcia S Campos, Zhaocheng Zhang, Juliana Moren, Theodora E Danciu, Jacques E Nör

Open Access Research article

miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis

Gang Wu, Haiyang Liu, Hui He, Yawei Wang, Xiaojun Lu, Yanqiu Yu, Shuguan Xia, Xiangyu Meng, Yongfeng Liu

Open Access Research article

MiR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer

Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li, Tong Zhou

Open Access Research article

TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells

Sahana Suresh Babu, Yanet Valdez, Andrea Xu, Alice M O’Byrne, Fernando Calvo, Victor Lei, Edward M Conway

Open Access Research article

Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment

Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison, Katerina Pestova

Open Access Research article

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao, Jiaqi Huang

Open Access Research article

Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang, Lin-Tao Jia

Open Access Research article

Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

Roberta Ciarapica, Elena Carcarino, Laura Adesso, Maria De Salvo, Giorgia Bracaglia, Pier Paolo Leoncini, Alessandra Dall’Agnese, Federica Verginelli, Giuseppe M Milano, Renata Boldrini, Alessandro Inserra, Stefano Stifani, Isabella Screpanti, Victor E Marquez, Sergio Valente, Antonello Mai, Pier Lorenzo Puri, Franco Locatelli, Daniela Palacios, Rossella Rota

Open Access Research article

Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Jun Wang, Bing Wei, Constance T Albarracin, Jianhua Hu, Susan C Abraham, Yun Wu

Open Access Study protocol

Treatment of gastric peritoneal carcinomatosis by combining complete surgical resection of lesions and intraperitoneal immunotherapy using catumaxomab

Diane Goéré, Nathalie Gras-Chaput, Anne Aupérin, Caroline Flament, Christophe Mariette, Olivier Glehen, Laurence Zitvogel, Dominique Elias

Open Access Research article

Knowledge, awareness and attitudes about cervical cancer among women attending or not an HIV treatment center in Lao PDR

Chanvilay SICHANH, Fabrice QUET, Phetsavanh CHANTHAVILAY, Joeffroy DIENDERE, Vatthanaphone LATTHAPHASAVANG, Christophe LONGUET, Yves BUISSON

Open Access Study protocol

Study protocol: a randomised controlled trial of a theory-based online intervention to improve sun safety among Australian adults

Cathy M Cleary, Katherine M White, Ross McD Young, Anna L Hawkes, Stuart Leske, Louise C Starfelt, Kylie Wihardjo

Open Access Research article

Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors

Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel, Guido Nikkhah

Open Access Research article

Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells

Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel, Ryszard Rzepecki

Open Access Research article

Androgen receptor CAG repeats, non-random X chromosome inactivation, and loss of heterozygosity at Xq25 in relation to breast cancer risk

Hui-Tzu Chen, Yao-Chung Wu, Shou-Tung Chen, Hsien-Chang Tsai, Yi-Chih Chien

Open Access Research article

Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan, Denghai Zhang

Open Access Research article

Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide

Lucio Tentori, Lucia Ricci-Vitiani, Alessia Muzi, Fabio Ciccarone, Federica Pelacchi, Roberta Calabrese, Daniele Runci, Roberto Pallini, Paola Caiafa, Grazia Graziani

Open Access Research article

Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients

Chann Lagadec, Erina Vlashi, Sunita Bhuta, Chi Lai, Paul Mischel, Martin Werner, Michael Henke, Frank Pajonk

Open Access Study protocol

Methylene blue-assisted technique for harvesting lymph nodes after radical surgery for gastric cancer: a prospective randomized phase III study

Toru Aoyama, Takaki Yoshikawa, Satoshi Morita, Junya Shirai, Hirohito Fujikawa, Kenichi Iwasaki, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Akira Tsuburaya

Open Access Research article

Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group

Thanh-Khoa Huynh, Pierre Meeus, Philippe Cassier, Olivier Bouché, Sophie Lardière-Deguelte, Antoine Adenis, Thierry André, Julien Mancini, Olivier Collard, Michael Montemurro, Emmanuelle Bompas, Maria Rios, Nicolas Isambert, Didier Cupissol, Jean-Yves Blay, Florence Duffaud

Open Access Research article

Histological review of skin cancers in African Albinos: a 10-year retrospective review

Samson Kimaiyo Kiprono, Baraka Michael Chaula, Helmut Beltraminelli

Open Access Research article

Increased paired box transcription factor 8 has a survival function in Glioma

Noelyn Hung, Yu-Jen Chen, Ahmad Taha, Magnus Olivecrona, Ronald Boet, Anna Wiles, Tracy Warr, Alisha Shaw, Ramona Eiholzer, Bruce C Baguley, Michael R Eccles, Antony W Braithwaite, Martin MacFarlane, Janice A Royds, Tania Slatter

Open Access Research article

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

Ji-Won Park, Seung Cheol Kim, Won Ki Kim, Jun Pyu Hong, Kyung-Hee Kim, Hyun Yang Yeo, Jae Yong Lee, M Sun Kim, Jong Heon Kim, Se Young Yang, Dae Yong Kim, Jae Hwan Oh, Jae Youl Cho, Byong Chul Yoo

Open Access Research article

Increasing rates of surgical treatment and preventing comorbidities may increase breast cancer survival for Aboriginal women

Rajah Supramaniam, Alison Gibberd, Anthony Dillon, David Eamon Goldsbury, Dianne L O’Connell

Open Access Research article

Cyr61 Expression is associated with prognosis in patients with colorectal cancer

Dongjun Jeong, Suhak Heo, Tae Sung Ahn, Sookyoung Lee, Soyoung Park, Hyungjoo Kim, Doosan Park, Sang Byung Bae, Sung Soo Lee, Moon Soo Lee, Chang-Jin Kim, Moo Jun Baek

Open Access Research article

Presence of intratumoral platelets is associated with tumor vessel structure and metastasis

Rong Li, Meiping Ren, Ni Chen, Mao Luo, Xin Deng, Jiyi Xia, Guang Yu, Jinbo Liu, Bing He, Xu Zhang, Zhuo Zhang, Xiao Zhang, Bing Ran, Jianbo Wu

Open Access Research article

Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing’s sarcoma via inhibition of cell migration

Guillaume Odri, Pui-Pui Kim, François Lamoureux, Céline Charrier, Séverine Battaglia, Jérôme Amiaud, Dominique Heymann, François Gouin, Françoise Redini

Open Access Research article

Ovarian cancer symptom awareness and anticipated delayed presentation in a population sample

Kate E Brain, Stephanie Smits, Alice E Simon, Lindsay J Forbes, Chris Roberts, Iain J Robbé, John Steward, Ceri White, Richard D Neal, Jane Hanson

Open Access Research article

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

Ji Ma, Yan Guo, Suning Chen, Cuiping Zhong, Yan Xue, Yuan Zhang, Xiaofeng Lai, Yifang Wei, Shentong Yu, Jian Zhang, Wenchao Liu

Open Access Research article

Identification and characterization of cancer stem cells in human head and neck squamous cell carcinoma

Jing Han, Toshio Fujisawa, Syed R Husain, Raj K Puri

Open Access Research article

Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer

Jin-Hee Seo, Eui-Suk Jeong, Yang-Kyu Choi

Open Access Study protocol

Can an alert in primary care electronic medical records increase participation in a population-based screening programme for colorectal cancer? COLO-ALERT, a randomised clinical trial

Carolina Guiriguet-Capdevila, Laura Muñoz-Ortiz, Irene Rivero-Franco, Carme Vela-Vallespín, Mercedes Vilarrubí-Estrella, Miquel Torres-Salinas, Jaume Grau-Cano, Andrea Burón-Pust, Cristina Hernández-Rodríguez, Antonio Fuentes-Peláez, Dolores Reina-Rodríguez, Rosa De León-Gallo, Leonardo Mendez-Boo, Pere Torán-Monserrat

Open Access Research article

Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma

Xiayun He, Duanshu Li, Chaosu Hu, Zhuoying Wang, Hongmei Ying, Yi Wu

Open Access Research article

Factors associated with work disability in employed cancer survivors at 24-month sick leave

Peter van Muijen, Saskia FA Duijts, Karin Bonefaas-Groenewoud, Allard J van der Beek, Johannes R Anema

Open Access Study protocol

Stem cell Transplantation for Eradication of Minimal PAncreatic Cancer persisting after surgical Excision (STEM PACE Trial, ISRCTN47877138): study protocol for a phase II study

Friedrich H Schmitz-Winnenthal, Thomas Schmidt, Monika Lehmann, Philipp Beckhove, Meinhard Kieser, Anthony D Ho, Peter Dreger, Markus W Büchler

Open Access Technical advance

Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells

Jeffrey Cummings, Robert Sloane, Karen Morris, Cong Zhou, Matt Lancashire, David Moore, Tony Elliot, Noel Clarke, Caroline Dive

Open Access Case report

Complete pathologic response of HER2-positive breast cancer liver metastasis with dual Anti-HER2 antagonism

Hans F Schoellhammer, Felicia Hsu, Courtney Vito, Peiguo Chu, Jinha Park, James Waisman, Joseph Kim

Open Access Research article

A phase II study of cisplatin with intravenous and oral vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy with oral vinorelbine and cisplatin for locally advanced non-small cell lung cancer

Delphine Lerouge, Alain Rivière, Eric Dansin, Christos Chouaid, Cécile Dujon, Roland Schott, Armelle Lavole, Vincent Le Pennec, Elizabeth Fabre, Jacky Crequit, Francis Martin, Stéphanie Dehette, Pierre Fournel, Bénédicte Precheur-Agulhon, Eric Lartigau, Gérard Zalcman

Open Access Research article

Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer

Annika N Alexopoulou, Colan M Ho-Yen, Vassilis Papalazarou, George Elia, J Louise Jones, Kairbaan Hodivala-Dilke

Open Access Study protocol

Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods

Christina M Dieli-Conwright, Joanne E Mortimer, E Todd Schroeder, Kerry Courneya, Wendy Demark-Wahnefried, Thomas A Buchanan, Debu Tripathy, Leslie Bernstein

Open Access Research article

p21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer

Sung Hoon Sim, Mi-Hyun Kang, Yu Jung Kim, Keun-Wook Lee, Duck-Woo Kim, Sung-Bum Kang, Keun-Yong Eom, Jae-Sung Kim, Hye Seung Lee, Jee Hyun Kim

Open Access Research article

RETRACTED ARTICLE: Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics

Damao Huang, Yuejin Li, Na Liu, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Faqing Tang

Open Access Research article

Evaluation of protein biomarkers of prostate cancer aggressiveness

Anthony E Rizzardi, Nikolaus K Rosener, Joseph S Koopmeiners, Rachel Isaksson Vogel, Gregory J Metzger, Colleen L Forster, Lauren O Marston, Jessica R Tiffany, James B McCarthy, Eva A Turley, Christopher A Warlick, Jonathan C Henriksen, Stephen C Schmechel

Open Access Research article

Changes in period and cohort effects on haematological cancer mortality in Spain, 1952-2006

Roberto Pastor-Barriuso, Gonzalo López-Abente

Open Access Research article

Space-time clusters of breast cancer using residential histories: A Danish case–control study

Rikke Baastrup Nordsborg, Jaymie R Meliker, Annette Kjær Ersbøll, Geoffrey M Jacquez, Aslak Harbo Poulsen, Ole Raaschou-Nielsen

Open Access Research article

Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions

Véronique Pomerleau, Mélissa Landry, Jimmy Bernier, Pierre H Vachon, Caroline Saucier

Open Access Study protocol

Study protocol of the RAND-study: a multicenter, prospective cohort study investigating response and adherence to nilotinib treatment in chronic myeloid leukemia

Christel CLM Boons, Eleonora L Swart, Lonneke Timmers, Peter M van de Ven, Jeroen JWM Janssen, Jacqueline G Hugtenburg

Open Access Research article

NILCO biomarkers in breast cancer from Chinese patients

Laronna S Colbert, Kaamilah Wilson, Sungjin Kim, Yuan Liu, Gabriela Oprea-Ilies, Corey Gillespie, Toi Dickson, Gale Newman, Ruben Rene Gonzalez-Perez

Open Access Research article

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma

Chantal van de Schootbrugge, Elisabeth MJ Schults, Johan Bussink, Paul N Span, Reidar Grénman, Ger JM Pruijn, Johannes HAM Kaanders, Wilbert C Boelens

Open Access Research article

The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer

Kelly A Avery-Kiejda, Stephen G Braye, John F Forbes, Rodney J Scott

Open Access Research article

Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients

Tjaša Vižin, Ib Jarle Christensen, Michael Wilhelmsen, Hans Jørgen Nielsen, Janko Kos

Open Access Research article

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway

Runfa Bao, Yijun Shu, Xiangsong Wu, Hao Weng, Qian Ding, Yang Cao, Maolan Li, Jiasheng Mu, Wenguang Wu, Qichen Ding, Zhujun Tan, Tianyu Liu, Lin Jiang, Yunping Hu, Jianfeng Gu, Yingbin Liu

Open Access Research article

RETRACTED ARTICLE: Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho

Xu-Jun He, Ying-Yu Ma, Sheng Yu, Xiao-Ting Jiang, Yi-Ding Lu, Liang Tao, Hua-Ping Wang, Zhi-Ming Hu, Hou-Quan Tao

Open Access Research article

Impairment of cognitive functioning during Sunitinib or Sorafenib treatment in cancer patients: a cross sectional study

Sasja F Mulder, Dirk Bertens, Ingrid ME Desar, Kris CP Vissers, Peter FA Mulders, Cornelis JA Punt, Dick-Johan van Spronsen, Johan F Langenhuijsen, Roy PC Kessels, Carla ML van Herpen

Open Access Research article

Study of the cytotoxicity of asiaticoside on rats and tumour cells

Fatma J Al-Saeedi

Open Access Research article

Primary small cell carcinoma of the esophagus: clinicopathological study of 44 cases

Wei-Wei Chen, Feng Wang, Dong-Sheng Zhang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Miao-Zhen Qiu, Chao Ren, Xiao-Li Wei, Wen-Jing Wu, Yu-Hong Li, Rui-Hua Xu

Open Access Research article

Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

Lopamudra Das Roy, Mahnaz Sahraei, Jorge L Schettini, Helen E Gruber, Dahlia M Besmer, Pinku Mukherjee

Open Access Research article

A retrospective analysis of survival and prognostic factors of male breast cancer from a single center

Amr A Soliman, Adel T Denewer, Wael El-Sadda, Ali H Abdel-Aty, Basel Refky

Open Access Research article

Feeling well and talking about sex: psycho-social predictors of sexual functioning after cancer

Janette Perz, Jane M Ussher, Emilee Gilbert

Open Access Research article

Breast density and mode of detection in relation to breast cancer specific survival: a cohort study

Åsa Olsson, Hanna Sartor, Signe Borgquist, Sophia Zackrisson, Jonas Manjer

Open Access Research article

Is provider type associated with cancer screening and prevention: advanced practice registered nurses, physician assistants, and physicians

Deanna Kepka, Alexandria Smith, Christopher Zeruto, K Robin Yabroff

Open Access Research article

MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression

Isabelle Matte, Denis Lane, Marianne Boivin, Claudine Rancourt, Alain Piché

Open Access Research article

Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice

Yanyuan Wu, Juri Kim, Yayha Elshimali, Marianna Sarkissyan, Jaydutt V Vadgama

Open Access Research article

Serum soluble ST2 is associated with ER-positive breast cancer

Da-peng Lu, Xiang-yu Zhou, Lu-tian Yao, Cai-gang Liu, Wei Ma, Feng Jin, Yun-fei Wu

Open Access Study protocol

Improving sexual health in men with prostate cancer: randomised controlled trial of exercise and psychosexual therapies

Prue Cormie, Suzanne K Chambers, Robert U Newton, Robert A Gardiner, Nigel Spry, Dennis R Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A Galvão

Open Access Research article

MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers

Silvia Zearo, Edward Kim, Ying Zhu, Jing Ting Zhao, Stan B Sidhu, Bruce G Robinson, Patsy SH Soon

Open Access Research article

Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors

Alena M Pfeil, Christof Vulsteke, Robert Paridaens, Anne-Sophie Dieudonné, Ruth Pettengell, Sigrid Hatse, Patrick Neven, Diether Lambrechts, Thomas D Szucs, Matthias Schwenkglenks, Hans Wildiers

Open Access Study protocol

Ion Prostate Irradiation (IPI) – a pilot study to establish the safety and feasibility of primary hypofractionated irradiation of the prostate with protons and carbon ions in a raster scan technique

Gregor Habl, Gencay Hatiboglu, Lutz Edler, Matthias Uhl, Sonja Krause, Matthias Roethke, Heinz P Schlemmer, Boris Hadaschik, Juergen Debus, Klaus Herfarth

Open Access Debate

DNA damage response and DNA repair – dog as a model?

Nicole Grosse, Barbara van Loon, Carla Rohrer Bley

Open Access Research article

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer – the CONKO 004 pilot trial

Uwe Pelzer, Andreas Hilbig, Jens M Stieler, Marcus Bahra, Marianne Sinn, Bernhard Gebauer, Bernd Dörken, Hanno Riess

Open Access Research article

Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin

Brian Hutzen, Hemant Kumar Bid, Peter J Houghton, Christopher R Pierson, Kimerly Powell, Anna Bratasz, Corey Raffel, Adam W Studebaker

Open Access Study protocol

Rationale and design of the iPap trial: a randomized controlled trial of home-based HPV self-sampling for improving participation in cervical screening by never- and under-screened women in Australia

Farhana Sultana, Dallas R English, Julie A Simpson, Julia ML Brotherton, Kelly Drennan, Robyn Mullins, Stella Heley, C David Wrede, Marion Saville, Dorota M Gertig

Open Access Study protocol

Standardization of D2 lymphadenectomy and surgical quality control (KLASS-02-QC): a prospective, observational, multicenter study [NCT01283893]

Hyoung-Il Kim, Hoon Hur, Youn Nam Kim, Hyuk-Joon Lee, Min-Chan Kim, Sang-Uk Han, Woo Jin Hyung

Open Access Research article

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

Trude E Robsahm, Margaret R Karagas, Judy R Rees, Astri Syse

Open Access Research article

Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status

Xi Zhao, Einar Andreas Rødland, Therese Sørlie, Hans Kristian Moen Vollan, Hege G Russnes, Vessela N Kristensen, Ole Christian Lingjærde, Anne-Lise Børresen-Dale

Open Access Research article

Closing the global cancer divide- performance of breast cancer care services in a middle income developing country

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DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma

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Loss of MTUS1/ATIP expression is associated with adverse outcome in advanced bladder carcinomas: data from a retrospective study

Anja Rogler, Sabine Hoja, Johannes Giedl, Arif B Ekici, Sven Wach, Helge Taubert, Peter J Goebell, Bernd Wullich, Michael Stöckle, Jan Lehmann, Sabrina Petsch, Arndt Hartmann, Robert Stoehr

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Clinical research of genetically modified dendritic cells in combination with cytokine-induced killer cell treatment in advanced renal cancer

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High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer

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Cost-effectiveness of family history-based colorectal cancer screening in Australia

Driss A Ouakrim, Alex Boussioutas, Trevor Lockett, John L Hopper, Mark A Jenkins

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Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

Nam P Nguyen, Siyoung Jang, Jacqueline Vock, Vincent Vinh-Hung, Alexander Chi, Paul Vos, Judith Pugh, Richard A Vo, Misty Ceizyk, Anand Desai, Lexie Smith-Raymond

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Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

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Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1

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Open Access Research article

Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

Alexander B Philipp, Dorothea Nagel, Petra Stieber, Rolf Lamerz, Isabel Thalhammer, Andreas Herbst, Frank T Kolligs

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Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype

Zunling Li, Yanxia Guo, Hanming Jiang, Tingguo Zhang, Changzhu Jin, Charles YF Young, Huiqing Yuan

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Capecitabine in combination with oxaliplatin and bevacizumab (AXELOX) as 1st line treatment for fit and vulnerable elderly patients (aged >70 years) with metastatic colorectal cancer (mCRC): a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

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Open Access Research article

Inhibition of autophagy enhances the cytotoxic effect of PA-MSHA in breast cancer

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Open Access Study protocol

Decrease social inequalities return-to-work: development and design of a randomised controlled trial among women with breast cancer

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Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging

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Development of a scale to assess cancer stigma in the non-patient population

Laura AV Marlow, Jane Wardle

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N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells

Satish Bodakuntla, Libi Anandi V, Surojit Sural, Prasad Trivedi, Mayurika Lahiri

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Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration

Ambrish Kumar, Jianjun Hu, Holly A LaVoie, Kenneth B Walsh, Donald J DiPette, Ugra S Singh

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A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells

Tina Di Palma, Valeria Lucci, Tiziana de Cristofaro, Maria Grazia Filippone, Mariastella Zannini

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A novel oxygen carrier “YQ23” suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells

Chang Xian Li, Bing L Wong, Chang Chun Ling, Yuen Yuen Ma, Yan Shao, Wei Geng, Xiang Qi, Sze Hang Lau, Sui Yi Kwok, Na Wei, Fei Chuen Tzang, Kevin TP Ng, Xiao Bing Liu, Chung Mau Lo, Kwan Man

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Long-term use of metformin and the molecular subtype in invasive breast carcinoma patients – a retrospective study of clinical and tumor characteristics

Nikola Besic, Nika Satej, Ivica Ratosa, Andreja Gojkovic Horvat, Tanja Marinko, Barbara Gazic, Rok Petric

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Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays

Britta Weber, Peter Meldgaard, Henrik Hager, Lin Wu, Wen Wei, Julie Tsai, Azza Khalil, Ebba Nexo, Boe S Sorensen

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Ganglioside GD2 in reception and transduction of cell death signal in tumor cells

Igor I Doronin, Polina A Vishnyakova, Irina V Kholodenko, Eugene D Ponomarev, Dmitry Y Ryazantsev, Irina M Molotkovskaya, Roman V Kholodenko

Open Access Research article

Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection

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Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia

Mauricio J Farfan, Carolina Salas, Cristina Canales, Felipe Silva, Milena Villarroel, Katherine Kopp, Juan P Torres, María E Santolaya, Jorge Morales

Open Access Research article

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Tetsuji Terazawa, Shunsuke Kondo, Hiroko Hosoi, Chigusa Morizane, Satoshi Shimizu, Shuichi Mitsunaga, Masafumi Ikeda, Hideki Ueno, Takuji Okusaka

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Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling

María D Cuenca-López, Juan C Montero, Jorge C Morales, Aleix Prat, Atanasio Pandiella, Alberto Ocana

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Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDHhighCD44+ phenotype and sphere-forming capacity

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Open Access Study protocol

The SystHERs registry: an observational cohort study of treatment patterns and outcomes in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer

Debu Tripathy, Hope S Rugo, Peter A Kaufman, Sandra Swain, Joyce O’Shaughnessy, Mohammad Jahanzeb, Ginny Mason, Mary Beattie, Bongin Yoo, Catherine Lai, Anthony Masaquel, Sara Hurvitz

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Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure

Ovidiu Balacescu, Loredana Balacescu, Oana Tudoran, Nicolae Todor, Meda Rus, Rares Buiga, Sergiu Susman, Bogdan Fetica, Laura Pop, Laura Maja, Simona Visan, Claudia Ordeanu, Ioana Berindan-Neagoe, Viorica Nagy

Open Access Case report

Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

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Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma

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Aleksandra B Adomas, Sara A Grimm, Christine Malone, Motoki Takaku, Jennifer K Sims, Paul A Wade

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Vascular measurements correlate with estrogen receptor status

Mark C Lloyd, Khalid O Alfarouk, Daniel Verduzco, Marilyn M Bui, Robert J Gillies, Muntaser E Ibrahim, Joel S Brown, Robert A Gatenby

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He Zhang, Hong-bing Liu, Dong-mei Yuan, Zhao-feng Wang, Yun-fen Wang, Yong Song

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Identification of breast cancer patients with a high risk of developing brain metastases: a single-institutional retrospective analysis

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Open Access Review

Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

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Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996–2010

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Bevacizumab with 5-fluorouracil, leucovorin, and oxaliplatin versus bevacizumab with capecitabine and oxaliplatin for metastatic colorectal carcinoma: results of a large registry-based cohort analysis

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Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

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RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

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The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

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Trends in oral cavity, pharyngeal, oesophageal and gastric cancer mortality rates in Spain, 1952–2006: an age-period-cohort analysis

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Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans

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Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity

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Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

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Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

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Demethylation of the miR-146a promoter by 5-Aza-2’-deoxycytidine correlates with delayed progression of castration-resistant prostate cancer

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Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors

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Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model

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Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

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Open Access Research article

Smoking increases rectal cancer risk to the same extent in women as in men: results from a Norwegian cohort study

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YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells

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Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

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Open Access Hypothesis

Epistemology of the origin of cancer: a new paradigm

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Open Access Research article

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

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Predictors of recurrence free survival for patients with stage II and III colon cancer

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Open Access Research article

Diffuse large B cell lymphoma derived from nodular lymphocyte predominant Hodgkin lymphoma presents with variable histopathology

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Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma

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Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

Carlos KH Wong, Wai-Lun Law, Yuk-Fai Wan, Jensen Tung-Chung Poon, Cindy Lo-Kuen Lam

Open Access Research article

Genome instability in blood cells of a BRCA1 + breast cancer family

Fengxia Xiao, Yeong C Kim, Carrie Snyder, Hongxiu Wen, Pei Xian Chen, Jiangtao Luo, Dina Becirovic, Bradley Downs, Kenneth H Cowan, Henry Lynch, San Ming Wang

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Higher incidence of premenopausal breast cancer in less developed countries; myth or truth?

Reza Ghiasvand, Hans-Olov Adami, Iraj Harirchi, Rahim Akrami, Kazem Zendehdel

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Incidence and outcome for patients with occult lymph node involvement in T1 and T2 oral squamous cell carcinoma: a prospective study

Thomas Mücke, David A Mitchell, Stefan Wagenpfeil, Lucas M Ritschl, Klaus-Dietrich Wolff, Anastasios Kanatas

Open Access Study protocol

Dexamethasone for the prevention of a pain flare after palliative radiotherapy for painful bone metastases: a multicenter double-blind placebo-controlled randomized trial

Paulien G Westhoff, Alexander de Graeff, Jenske I Geerling, Anna KL Reyners, Yvette M van der Linden

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Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial

Falk Roeder, Burkhard Lehner, Thomas Schmitt, Bernd Kasper, Gerlinde Egerer, Oliver Sedlaczek, Carsten Grüllich, Gunhild Mechtersheimer, Patrick Wuchter, Frank W Hensley, Peter E Huber, Juergen Debus, Marc Bischof

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Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls

Sergio Pérez-Holanda, Ignacio Blanco, Manuel Menéndez, Luis Rodrigo

Open Access Research article

Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma

I-Che Chung, Lih-Chyang Chen, An-Ko Chung, Mei Chao, Hsin-Yi Huang, Chuen Hsueh, Ngan-Ming Tsang, Kai-Ping Chang, Ying Liang, Hsin-Pai Li, Yu-Sun Chang

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Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab

Huan Cheng, Yalai Bai, William Sikov, Natalie Sinclair, Veerle Bossuyt, Maysa M Abu-Khalaf, Lyndsay N Harris, David L Rimm

Open Access Research article

The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma

Marcel Klingenberg, Jürgen Becker, Sonja Eberth, Dieter Kube, Jörg Wilting

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Temporal evolution in caveolin 1 methylation levels during human esophageal carcinogenesis

Zhe Jin, Liang Wang, Ziyi Cao, Yulan Cheng, Yan Gao, Xianling Feng, Si Chen, Huimin Yu, Wenjing Wu, Zhenfu Zhao, Ming Dong, Xiaojing Zhang, Jie Liu, Xinmin Fan, Yuriko Mori, Stephen J Meltzer

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MicroRNAs define distinct human neuroblastoma cell phenotypes and regulate their differentiation and tumorigenicity

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Antagonism of Sorafenib and Regorafenib actions by platelet factors in hepatocellular carcinoma cell lines

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Open Access Research article

CA15-3 is a useful serum tumor marker for diagnostic integration of hybrid positron emission tomography with integrated computed tomography during follow-up of breast cancer patients

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Open Access Research article

Individual risk of cutaneous melanoma in New Zealand: developing a clinical prediction aid

Mary Jane Sneyd, Claire Cameron, Brian Cox

Open Access Research article

Survival advantage of partial over radical nephrectomy in patients presenting with localized renal cell carcinoma

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Open Access Research article

Immunotherapy of hepatocellular carcinoma with small double-stranded RNA

Tatyana O Kabilova, Larisa V Kovtonyuk, Evgeniy V Zonov, Elena I Ryabchikova, Nelly A Popova, Valeriy P Nikolin, Vasiliy I Kaledin, Marina A Zenkova, Valentin V Vlassov, Elena L Chernolovskaya

Open Access Research article

Clinicopathological analysis of thymic malignancies with a consistent retrospective database in a single institution: from Tokyo Metropolitan Cancer Center

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Open Access Research article

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

Nelma Pértega-Gomes, José R Vizcaíno, Jan Attig, Sarah Jurmeister, Carlos Lopes, Fátima Baltazar

Open Access Research article

A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic and immunological analysis

Chih-Ming Lu, Jen-Jie Lin, Han-Hsiang Huang, Ying-Chin Ko, Jue-Liang Hsu, Jiing-Chuan Chen, Zhong-Hao Din, Yu-Jen Wu

Open Access Research article

Prevalence of gastrointestinal stromal tumour (GIST) in the United Kingdom at different therapeutic lines: an epidemiologic model

Justyna M Starczewska Amelio, Javier Cid Ruzafa, Kamal Desai, Spiros Tzivelekis, Dominic Muston, Javaria Mona Khalid, Philip Ashman, Andrew Maguire

Open Access Research article

Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients

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Open Access Research article

Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice

Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth, Edward P Rybicki

Open Access Research article

Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma

Siming Li, Yan Kong, Lu Si, Zhihong Chi, Chuanliang Cui, Xinan Sheng, Jun Guo

Open Access Research article

Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study

Hao Zhang, Jiyue Gao, Zuowei Zhao, Man Li, Caigang Liu

Open Access Research article

Cancer incidence in Ghana, 2012: evidence from a population-based cancer registry

Dennis O Laryea, Baffour Awuah, Yaw A Amoako, E Osei-Bonsu, Joslin Dogbe, Rita Larsen-Reindorf, Daniel Ansong, Kwasi Yeboah-Awudzi, Joseph K Oppong, Thomas O Konney, Kwame O Boadu, Samuel B Nguah, Nicholas A Titiloye, Nicholas O Frimpong, Fred K Awittor, Iman K Martin

Open Access Study protocol

The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life

Renate M Winkels, Renate C Heine-Bröring, Moniek van Zutphen, Suzanne van Harten-Gerritsen, Dieuwertje EG Kok, Fränzel JB van Duijnhoven, Ellen Kampman

Open Access Research article

FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab

Janne B Kjersem, Eva Skovlund, Tone Ikdahl, Tormod Guren, Christian Kersten, Astrid M Dalsgaard, Mette K Yilmaz, Tone Fokstuen, Kjell M Tveit, Elin H Kure

Open Access Research article

Investigation of HOXA9 promoter methylation as a biomarker to distinguish oral cancer patients at low risk of neck metastasis

Kenichiro Uchida, Ratna Veeramachaneni, Bing Huey, Aditi Bhattacharya, Brian L Schmidt, Donna G Albertson

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Tumors induce coordinate growth of artery, vein, and lymphatic vessel triads

Alanna Ruddell, Alexandra Croft, Karen Kelly-Spratt, Momoko Furuya, Christopher J Kemp

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Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy

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Open Access Research article

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

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Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer

Jacqueline Banyard, Ivy Chung, Matthew Migliozzi, Derek T Phan, Arianne M Wilson, Bruce R Zetter, Diane R Bielenberg

Open Access Research article

What do women with gynecologic cancer know about HPV and their individual disease? A pilot study

Sophie Pils, Elmar A Joura, Max-Paul Winter, Anup Shrestha, Agnes Jaeger-Lansky, Johannes Ott

Open Access Research article

Bimodal mortality dynamics for uveal melanoma: a cue for metastasis development traits?

Romano Demicheli, Marco Fornili, Elia Biganzoli

Open Access Case report

Leptomeningeal metastasis from hepatocellular carcinoma with other unusual metastases: a case report

Zhenyu Pan, Guozi Yang, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Limei Qu, Lihua Dong

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The development and validation of oral cancer staging using administrative health data

Chang Li-Ting, Chen Chung-Ho, Yang Yi-Hsin, Ho Pei-Shan

Open Access Research article

Differential expression patterns and clinical significance of estrogen receptor-α and β in papillary thyroid carcinoma

Yanhong Huang, Wenwu Dong, Jing Li, Hao Zhang, Zhongyan Shan, Weiping Teng

Open Access Research article

Expression of E-cadherin and β-catenin in basaloid and conventional squamous cell carcinoma of the oral cavity: are potential prognostic markers?

João Adolfo Costa Hanemann, Denise Tostes Oliveira, Suely Nonogaki, Inês Nobuko Nishimoto, Marina Lara de Carli, Gilles Landman, Luiz Paulo Kowalski

Open Access Research article

Thrombomodulin expression regulates tumorigenesis in bladder cancer

Chun-Te Wu, Ying-Hsu Chang, Paul- Yang Lin, Wen-Cheng Chen, Miao-Fen Chen

Open Access Study protocol

Correlating tumor metabolic progression index measured by serial FDG PET-CT, apparent diffusion coefficient measured by magnetic resonance imaging (MRI) and blood genomics to patient’s outcome in advanced colorectal cancer: the CORIOLAN study

Amelie Deleporte, Marianne Paesmans, Camilo Garcia, Caroline Vandeputte, Marc Lemort, Jean-Luc Engelholm, Frederic Hoerner, Philippe Aftimos, Ahmad Awada, Nicolas Charette, Godelieve Machiels, Martine Piccart, Patrick Flamen, Alain Hendlisz

Open Access Research article

A combination of p300 and Braf expression in the diagnosis and prognosis of melanoma

Madhuri Bhandaru, Gholamreza Safaee Ardekani, Guohong Zhang, Magdalena Martinka, Kevin J McElwee, Gang Li, Anand Rotte

Open Access Research article

Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer

Peng Chen, Wei-Miao Li, Qiang Lu, Jian Wang, Xiao-Long Yan, Zhi-Pei Zhang, Xiao-Fei Li

Open Access Research article

Human Papillomavirus 16, 18, 31 and 45 viral load, integration and methylation status stratified by cervical disease stage

Luigi Marongiu, Anna Godi, John V Parry, Simon Beddows

Open Access Study protocol

Perioperative rehabilitation in operation for lung cancer (PROLUCA) – rationale and design

Maja S Sommer, Karen Trier, Jette Vibe-Petersen, Malene Missel, Merete Christensen, Klaus R Larsen, Seppo W Langer, Carsten Hendriksen, Paul Clementsen, Jesper H Pedersen, Henning Langberg

Open Access Research article

The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity

Takahito Nakajima, Kazuhide Sato, Hirofumi Hanaoka, Rira Watanabe, Toshiko Harada, Peter L Choyke, Hisataka Kobayashi

Open Access Research article

Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients

Natalia Krawczyk, Andreas Hartkopf, Malgorzata Banys, Franziska Meier-Stiegen, Annette Staebler, Markus Wallwiener, Carmen Röhm, Juergen Hoffmann, Markus Hahn, Tanja Fehm

Open Access Research article

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Peng Sun, Shuli Xia, Bachchu Lal, Xiaohai Shi, Kil Sung Yang, Paul A Watkins, John Laterra

Open Access Research article

Modeling optimal cervical cancer prevention strategies in Nigeria

Nadia Demarteau, Imran O Morhason-Bello, Babatunde Akinwunmi, Isaac F Adewole

Open Access Research article

Evaluation of the impact of transient interruption of antiangiogenic treatment using ultrasound-based techniques in a murine model of hepatocellular carcinoma

Sara Marinelli, Veronica Salvatore, Marco Baron Toaldo, Maddalena Milazzo, Luca Croci, Laura Venerandi, Anna Pecorelli, Chiara Palamà, Alessia Diana, Luigi Bolondi, Fabio Piscaglia

Open Access Research article

Identification of prognostic factors and surgical indications for metastatic gastric cancer

Yasuhiko Mohri, Koji Tanaka, Masaki Ohi, Susumu Saigusa, Hiromi Yasuda, Yuji Toiyama, Toshimitu Araki, Yasuhiro Inoue, Masato Kusunoki

Open Access Study protocol

Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893, ISRCTN82191749)

Michael Tachezy, Florian Gebauer, Cordula Petersen, Dirk Arnold, Martin Trepel, Karl Wegscheider, Phillipe Schafhausen, Maximilian Bockhorn, Jakob Robert Izbicki, Emre Yekebas

Open Access Research article

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Ji Wook Moon, Soo Kyung Lee, Yong Woo Lee, Jung Ok Lee, Nami Kim, Hye Jeong Lee, Jung Seon Seo, Jin Kim, Hyeon Soo Kim, Sun-Hwa Park

Open Access Research article

Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan

Cheng-Chieh Lin, Jen-Huai Chiang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Teng-Fu Hsieh, Tsai-Chung Li

Open Access Research article

Altered glutamyl-aminopeptidase activity and expression in renal neoplasms

Lorena Blanco, Begoña Sanz, Itxaro Perez, Clara E Sánchez, M Luz Cándenas, Francisco M Pinto, Javier Gil, Luis Casis, José I López, Gorka Larrinaga

Open Access Research article

Adherence to hormone therapy among women with breast cancer

Claudia Brito, Margareth Crisóstomo Portela, Mauricio Teixeira Leite de Vasconcellos

Open Access Research article

Inaugural bone metastases in non-small cell lung cancer: a specific prognostic entity?

Mélanie Deberne, Stanislas Ropert, Bertrand Billemont, Catherine Daniel, Jeanne Chapron, François Goldwasser

Open Access Research article

Changes in vitamin and mineral supplement use after breast cancer diagnosis in the Pathways Study: a prospective cohort study

Heather Greenlee, Marilyn L Kwan, Isaac J Ergas, Garrett Strizich, Janise M Roh, Allegra T Wilson, Marion Lee, Karen J Sherman, Christine B Ambrosone, Dawn L Hershman, Alfred I Neugut, Lawrence H Kushi

Open Access Case report

FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities

Alberto L’Abbate, Crocifissa Lo Cunsolo, Ettore Macrì, Paolo Iuzzolino, Cristina Mecucci, Claudio Doglioni, Michelina Coco, Lucia Anna Muscarella, Simona Salati, Enrico Tagliafico, Carla Minoia, Giacoma De Tullio, Attilio Guarini, Nicoletta Testoni, Claudio Agostinelli, Clelia Tiziana Storlazzi

Open Access Research article

Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline

Naoki Aomatsu, Masakazu Yashiro, Shinichiro Kashiwagi, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Kenichi Wakasa, Kosei Hirakawa

Open Access Research article

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

Yue Ma, Jienan Kong, Guanghai Yan, Xiangshan Ren, Dan Jin, Tiefeng Jin, Lijuan Lin, Zhenhua Lin

Open Access Research article

Increased health care utilization by survivors of childhood lymphoblastic leukemia is confined to those treated with cranial or total body irradiation: a case cohort study

Anna Sällfors Holmqvist, Christian Moëll, Lars Hjorth, Anna Lindgren, Stanislaw Garwicz, Thomas Wiebe, Ingrid Øra

Open Access Research article

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

Zuzana Ditte, Peter Ditte, Martina Labudova, Veronika Simko, Filippo Iuliano, Miriam Zatovicova, Lucia Csaderova, Silvia Pastorekova, Jaromir Pastorek

Open Access Research article

A germline mutation in the BRCA13’UTR predicts Stage IV breast cancer

Jemima J Dorairaj, David W Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine AW Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J Kerin, Marie Wood, Nicola Miller, Joanne B Weidhaas

Open Access Research article

Monitoring changes in circulating tumour cells as a prognostic indicator of overall survival and treatment response in patients with metastatic melanoma

Dragana Klinac, Elin S Gray, James B Freeman, Anna Reid, Samantha Bowyer, Michael Millward, Melanie Ziman

Open Access Research article

14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma

Chia-Chia Liu, Yee-Jee Jan, Bor-Sheng Ko, Yao-Ming Wu, Shu-Man Liang, Shyh-Chang Chen, Yen-Ming Lee, Tzu-An Liu, Tzu-Ching Chang, John Wang, Song-Kun Shyue, Li-Ying Sung, Jun-Yang Liou

Open Access Research article

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Maria Giulia Bacalini, Annalisa Pacilli, Cristina Giuliani, Marianna Penzo, Davide Treré, Chiara Pirazzini, Stefano Salvioli, Claudio Franceschi, Lorenzo Montanaro, Paolo Garagnani

Open Access Research article

Survival analysis of patients with non-small cell lung cancer who underwent surgical resection following 4 lung cancer resection guidelines

Dongsheng Yue, Liqun Gong, Jian You, Yanjun Su, Zhenfa Zhang, Zhen Zhang, Feng Gu, Meng Wang, Changli Wang

Open Access Research article

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer

Linna Su, Xiangqiang Liu, Na Chai, Lifen Lv, Rui Wang, Xiaosa Li, Yongzhan Nie, Yongquan Shi, Daiming Fan

Open Access Research article

MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X

Gang Shen, Ye Lin, Xuewei Yang, Jing Zhang, Zhe Xu, Hongyun Jia

Open Access Research article

COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration

Antoine Boudot, Gwenneg Kerdivel, Sylvain Lecomte, Gilles Flouriot, Mireille Desille, Florence Godey, Jean Leveque, Patrick Tas, Yves Le Dréan, Farzad Pakdel

Open Access Research article

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

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Open Access Research article

Aspirin intake and breast cancer survival – a nation-wide study using prospectively recorded data in Sweden

Michelle D Holmes, Henrik Olsson, Yudi Pawitan, Johanna Holm, Cecilia Lundholm, Therese M-L Andersson, Hans-Olov Adami, Johan Askling, Karin Ekström Smedby

Open Access Research article

Volumetric FDG-PET predicts overall and progression- free survival after 14 days of targeted therapy in metastatic renal cell carcinoma

Jacob Farnebo, Per Grybäck, Ulrika Harmenberg, Anna Laurell, Peter Wersäll, Lennart K Blomqvist, Anders Ullén, Per Sandström

Open Access Research article

Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea

Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass

Open Access Research article

The early response of renal cell carcinoma to tyrosine kinase inhibitors evaluated by FDG PET/CT was not influenced by metastatic organ

Manabu Kakizoe, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takeshi Kishida, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Masataka Taguri, Satoshi Morita, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

Open Access Research article

B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells

Qiang Wu, Xue Liu, Hong Yan, Yin-huan He, Shan Ye, Xing-wang Cheng, Gui-lu Zhu, Wen-yong Wu, Xiao-nan Wang, Xiang-jun Kong, Xiao-chun Xu, Peter E Lobie, Tao Zhu, Zheng-sheng Wu

Open Access Study protocol

Steps toward improving diet and exercise for cancer survivors (STRIDE): a quasi-randomised controlled trial protocol

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Open Access Research article

MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3α

Caroline MM Gits, Patricia F van Kuijk, Jonneke CWM de Rijck, Nikky Muskens, Moniek BE Jonkers, Wilfred F van IJcken, Ron HJ Mathijssen, Jaap Verweij, Stefan Sleijfer, Erik AC Wiemer

Open Access Research article

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells

Ingvild J Brusevold, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Dagny L Sandnes, Thoralf Christoffersen

Open Access Research article

Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis

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Open Access Research article

Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia

Milena Camargo, Sara C Soto-De Leon, Marina Munoz, Ricardo Sanchez, Diego Peña-Herrera, Andrea Clemencia Pineda-Peña, Otto Sussmann, Carol Paez, Antonio Perez-Prados, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

Open Access Research article

Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma

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Open Access Research article

Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice

Tsz Yan Wong, Fengjuan Li, Shu-mei Lin, Franky L Chan, Shiuan Chen, Lai K Leung

Open Access Research article

ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis

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Open Access Research article

Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Glenn Deng, Sujatha Krishnakumar, Ashley A Powell, Haiyu Zhang, Michael N Mindrinos, Melinda L Telli, Ronald W Davis, Stefanie S Jeffrey

Open Access Research article

Overexpression of prostate tumor overexpressed 1 correlates with tumor progression and predicts poor prognosis in breast cancer

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Open Access Research article

Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer

Anshu Aggarwal, Rami N Al-Rohil, Anupam Batra, Paul J Feustel, David M Jones, C Michael DiPersio

Open Access Research article

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim

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Open Access Research article

Tyrosine phosphorylation profiling via in situproximity ligation assay

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Open Access Research article

MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells

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Characteristics, survival, and related factors of newly diagnosed colorectal cancer patients refusing cancer treatments under a universal health insurance program

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Open Access Research article

The genetic basis for inactivation of Wnt pathway in human osteosarcoma

Xiaoling Du, Jilong Yang, Da Yang, Wei Tian, Ze Zhu

Open Access Research article

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway

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Open Access Research article

FOLFOX as second-line chemotherapy in patients with pretreated metastatic pancreatic cancer from the FIRGEM study

Aziz Zaanan, Isabelle Trouilloud, Theofano Markoutsaki, Mélanie Gauthier, Anne-Claire Dupont-Gossart, Thierry Lecomte, Thomas Aparicio, Pascal Artru, Anne Thirot-Bidault, Fanny Joubert, Daniella Fanica, Julien Taieb

Open Access Research article

Oncogenic MicroRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum

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Open Access Research article

The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model

Eleonora Vannini, Anna Panighini, Chiara Cerri, Alessia Fabbri, Simonetta Lisi, Enrico Pracucci, Nicola Benedetto, Riccardo Vannozzi, Carla Fiorentini, Matteo Caleo, Mario Costa

Open Access Research article

Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS

Hidetatsu Outani, Takaaki Tanaka, Toru Wakamatsu, Yoshinori Imura, Kenichiro Hamada, Nobuhito Araki, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka

Open Access Research article

KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer

Jianli Wang, Siqin Ma, Rong Ma, Xun Qu, Wenjun Liu, Cuixia Lv, Song Zhao, Yunyun Gong

Open Access Research article

Real-time polymerase chain reaction analysis of MDM2 and CDK4expression using total RNA from core-needle biopsies is useful for diagnosing adipocytic tumors

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Open Access Research article

Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site

Matias Riihimäki, Akseli Hemminki, Kristina Sundquist, Kari Hemminki

Open Access Research article

High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model

Anna Zajakina, Jelena Vasilevska, Dmitry Zhulenkovs, Dace Skrastina, Artjoms Spaks, Aiva Plotniece, Tatjana Kozlovska

Open Access Research article

Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival

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Open Access Research article

FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J

Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin, Liang Liang, Si-Yong Huang, Ying-Min Liang, Hua Han, Hong-Yan Qin

Open Access Research article

Outcomes after stereotactic body radiotherapy for lung tumors, with emphasis on comparison of primary lung cancer and metastatic lung tumors

Takaya Yamamoto, Keiichi Jingu, Yuko Shirata, Masashi Koto, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Rei Umezawa, Keiko Abe, Noriyuki Kadoya, Youjirou Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Ken Takeda, Yoshihiro Takai

Open Access Research article

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

Hideyuki Abe, Takao Kamai, Keitaro Hayashi, Naohiko Anzai, Hiromichi Shirataki, Tomoya Mizuno, Yoshiyuki Yamaguchi, Akinori Masuda, Hideo Yuki, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Ken-Ichiro Yoshida

Open Access Study protocol

Impact of comprehensive geriatric assessment on survival, function, and nutritional status in elderly patients with head and neck cancer: protocol for a multicentre randomised controlled trial (EGeSOR)

Lydia Brugel, Marie Laurent, Philippe Caillet, Anne Radenne, Isabelle Durand-Zaleski, Michel Martin, Melany Baron, Héloïse de Kermadec, Sylvie Bastuji-Garin, Florence Canouï-Poitrine, Elena Paillaud

Open Access Research article

Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer

Zuzana Cierna, Michal Mego, Pavol Janega, Marian Karaba, Gabriel Minarik, Juraj Benca, Tatiana Sedlácková, Silvia Cingelova, Paulina Gronesova, Denisa Manasova, Daniel Pindak, Jozef Sufliarsky, Ludovit Danihel, James M Reuben, Jozef Mardiak

Open Access Research article

A grey literature review of special events for promoting cancer screenings

Cam Escoffery, Kirsten C Rodgers, Michelle C Kegler, Mary Ayala, Erika Pinsker, Regine Haardörfer

Open Access Research article

Inhibitory effects of prostaglandin E2on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma

Ewa Pomianowska, Dagny Sandnes, Krzysztof Grzyb, Aasa R Schjølberg, Monica Aasrum, Ingun H Tveteraas, Vegard Tjomsland, Thoralf Christoffersen, Ivar P Gladhaug

Open Access Research article

Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Hongxiu Wen, Yeong C Kim, Carrie Snyder, Fengxia Xiao, Elizabeth A Fleissner, Dina Becirovic, Jiangtao Luo, Bradley Downs, Simon Sherman, Kenneth H Cowan, Henry T Lynch, San Ming Wang

Open Access Research article

Time trends in socioeconomic inequalities in cancer mortality: results from a 35 year prospective study in British men

Sheena E Ramsay, Richard W Morris, Peter H Whincup, Anna Olia Papacosta, Lucy T Lennon, Sasiwarang Goya Wannamethee

Open Access Research article

Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line

Bianca Schröder-Heurich, Natalia Bogdanova, Britta Wieland, Xiaoxi Xie, Monika Noskowicz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen, Thilo Dörk

Open Access Research article

IL-1β mediates MCP-1 induction by Wnt5a in gastric cancer cells

Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma, Chenghai Zhao

Open Access Research article

Oncogenic Fli-1 is a potential prognostic marker for the progression of epithelial ovarian cancer

Wei Song, Lingyun Hu, Wei Li, Guanjun Wang, Yan Li, Lei Yan, Ailing Li, Jiuwei Cui

Open Access Research article

Colon and rectal cancer incidence and water trihalomethane concentrations in New South Wales, Australia

Md Bayzidur Rahman, Christine Cowie, Tim Driscoll, Richard J Summerhayes, Bruce K Armstrong, Mark S Clements

Open Access Case report

Solitary breast metastasis from myxoid liposarcoma

Masahiro Yokouchi, Satoshi Nagano, Yuko Kijima, Takako Yoshioka, Akihide Tanimoto, Shoji Natsugoe, Setsuro Komiya

Open Access Research article

TIMP-1 and responsiveness to gemcitabine in advanced breast cancer; results from a randomized phase III trial from the Danish breast cancer cooperative group

Charlotte Levin Tykjær Jørgensen, Christina Bjerre, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Annette Bartels, Nils Brünner, Dorte L Nielsen

Open Access Research article

Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea

Sohee Park, Sun Ha Jee, Hai-Rim Shin, Eun Hye Park, Aesun Shin, Kyu-Won Jung, Seung-Sik Hwang, Eun Shil Cha, Young Ho Yun, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta

Open Access Research article

Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain

Jason P Ross, Linda J Lockett, Bruce Tabor, Ian W Saunders, Graeme P Young, Finlay Macrae, Ignacio Blanco, Gabriel Capella, Glenn S Brown, Trevor J Lockett, Garry N Hannan

Open Access Case report

First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer

Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Lucia Bedei, Wainer Zoli, Dino Amadori, Fabio Falcini, Daniele Calistri

Open Access Research article

Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas

Masayo Adachi-Hayama, Akihiko Adachi, Natsuki Shinozaki, Tomoo Matsutani, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki, Yasuo Iwadate

Open Access Research article

RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53 abnormal myeloma cells independently of the p53 pathway

Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunynck

Open Access Research article

Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis

Xian-Tao Zeng, Wei Luo, Pei-Liang Geng, Yi Guo, Yu-Ming Niu, Wei-Dong Leng

Open Access Research article

VEGFR-3 and CXCR4 as predictive markers for treatment with fluorouracil, leucovorin plus either oxaliplatin or cisplatin in patients with advanced esophagogastric cancer: a comparative study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

Thomas Thomaidis, Annett Maderer, Salah-Eddin Al-Batran, Janis Kany, Claudia Pauligk, Kristina Steinmetz, Arno Schad, Ralf Hofheinz, Harald Schmalenberg, Nils Homann, Peter Robert Galle, Markus Moehler

Open Access Research article

Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells

Soyeon Jeong, Kaipeng Jing, Nayeong Kim, Soyeon Shin, Soyeon Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Tong Wu, Gi-Ryang Kweon, Seung-Kiel Park, Jong-Il Park, Kyu Lim

Open Access Research article

Pain response of resistance training of the paravertebral musculature under radiotherapy in patients with spinal bone metastases – a randomized trial

Harald Rief, Thomas Welzel, Georg Omlor, Michael Akbar, Thomas Bruckner, Stefan Rieken, Matthias F Haefner, Ingmar Schlampp, Alexandros Gioules, Jürgen Debus

Open Access Research article

Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study

Marlies S Reimers, Charla C Engels, Hein Putter, Hans Morreau, Gerrit Jan Liefers, Cornelis JH van de Velde, Peter JK Kuppen

Open Access Research article

Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma

Xin Zheng, Shan Xing, Xiao-Min Liu, Wen Liu, Dan Liu, Pei-Dong Chi, Hao Chen, Shu-Qin Dai, Qian Zhong, Mu-Sheng Zeng, Wan-Li Liu

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An effective and well-tolerated strategy in recurrent and/or metastatic head and neck cancer: successive lines of active chemotherapeutic agents

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CT based three dimensional dose-volume evaluations for high-dose rate intracavitary brachytherapy for cervical cancer

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Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis

Gillian K Gresham, George A Wells, Sharlene Gill, Christopher Cameron, Derek J Jonker

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Special role of Foxp3 for the specifically altered microRNAs in Regulatory T cells of HCC patients

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Selection criteria for radiofrequency ablation for colorectal liver metastases in the era of effective systemic therapy: a clinical score based proposal

Axel Stang, Karl Jürgen Oldhafer, Hauke Weilert, Handan Keles, Marcello Donati

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Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone

Burkhard Lehner, Pierre Kunz, Heiner Saehr, Joerg Fellenberg

Open Access Research article

Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis

Klaus Mross, Martin Büchert, Annette Frost, Michael Medinger, Peter Stopfer, Matus Studeny, Rolf Kaiser

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Tuomas Kaprio, Jaana Hagström, Christian Fermér, Harri Mustonen, Camilla Böckelman, Olle Nilsson, Caj Haglund

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Will D King, Janet E Ashbury, Sherryl A Taylor, M Yat Tse, Stephen C Pang, Jacob A Louw, Stephen J Vanner

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Ju Yang, Huanlei Wu, Sheng Wei, Huihua Xiong, Xiangning Fu, Zhaozhen Qi, Qian Jiang, Wen Li, Guangyuan Hu, Xianglin Yuan, Zhongxing Liao

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Kristina Bigelow, Thu A Nguyen

Open Access Research article

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Victoria K Hill, Thoraia Shinawi, Christopher J Ricketts, Dietmar Krex, Gabriele Schackert, Julien Bauer, Wenbin Wei, Garth Cruickshank, Eamonn R Maher, Farida Latif

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial

George Fountzilas, Urania Dafni, Christos Papadimitriou, Eleni Timotheadou, Helen Gogas, Anastasia G Eleftheraki, Ioannis Xanthakis, Christos Christodoulou, Angelos Koutras, Christos N Papandreou, Pavlos Papakostas, Spyros Miliaras, Christos Markopoulos, Constantine Dimitrakakis, Panagiotis Korantzopoulos, Charisios Karanikiotis, Dimitrios Bafaloukos, Paris Kosmidis, Epaminontas Samantas, Ioannis Varthalitis, Nicholas Pavlidis, Dimitrios Pectasides, Meletios-Athanassios Dimopoulos

Open Access Research article

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Open Access Case report

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Open Access Research article

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Open Access Study protocol

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Open Access Research article

Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

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Open Access Research article

Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol

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Open Access Research article

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

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Open Access Research article

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Open Access Research article

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Open Access Case report

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Open Access Research article

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Open Access Research article

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Open Access Case report

A rare case of watery diarrhea, hypokalemia and achlorhydria syndrome caused by pheochromocytoma

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Hypoxia represses microRNA biogenesis proteins in breast cancer cells

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Time trends in municipal distribution patterns of cancer mortality in Spain

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Identification of prognostic inflammatory factors in colorectal liver metastases

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Open Access Case report

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Open Access Research article

Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

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Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line

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Open Access Study protocol

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Open Access Research article

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

Augustine Chen, Henry Beetham, Michael A Black, Rashmi Priya, Bryony J Telford, Joanne Guest, George A R Wiggins, Tanis D Godwin, Alpha S Yap, Parry J Guilford

Open Access Research article

Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling

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3'-Ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

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Open Access Research article

Constitutive AKT activation in follicular lymphoma

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Open Access Research article

Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study

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Open Access Research article

Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers

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Open Access Research article

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

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Open Access Research article

Detection of infectious organisms in archival prostate cancer tissues

Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Anthony Longano, Suzanne M Garland, Melissa C Southey, Graham G Giles

Open Access Research article

Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer

Masafumi Horie, Akira Saito, Satoshi Noguchi, Yoko Yamaguchi, Mitsuhiro Ohshima, Yasuyuki Morishita, Hiroshi I Suzuki, Tadashi Kohyama, Takahide Nagase

Open Access Technical advance

Comparative evaluation of the new FDA approved THxID™-BRAF test with high resolution melting and sanger sequencing

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Open Access Research article

Evaluating the impact of public health initiatives on trends in fecal occult blood test participation in Ontario

Gladys N Honein-AbouHaidar, Linda Rabeneck, Lawrence F Paszat, Rinku Sutradhar, Jill Tinmouth, Nancy N Baxter

Open Access Research article

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

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Cardiac glycosides use and the risk of lung cancer: a nested case–control study

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A novel naproxen derivative capable of displaying anti-cancer and anti-migratory properties against human breast cancer cells

Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya, Siddhartha Sankar Jana

Open Access Research article

The clinical features and treatment modality of esophageal neuroendocrine tumors: a multicenter study in Korea

Chang Geun Lee, Yun Jeong Lim, Seun Ja Park, Byung Ik Jang, Seok Reyol Choi, Jae Kwang Kim, Yong-Tae Kim, Joo Young Cho, Chang Hun Yang, Hoon Jai Chun, Si Young Song

Open Access Research article

Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma

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Open Access Research article

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST

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Open Access Research article

Chk1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers

Christopher Bryant, Rebecca Rawlinson, Andrew J Massey

Open Access Research article

Trimodal therapy for stage III-N2 non-small-cell lung carcinoma: a single center retrospective analysis

Vasileios Askoxylakis, Judith Tanner, Jutta Kappes, Hans Hoffmann, Nils H Nicolay, Harald Rief, Juergen Debus, Michael Thomas, Marc Bischof

Open Access Research article

Protecting the underscreened women in developed countries: the value of HPV test

Raquel Ibáñez, Josefina Autonell, Montserrat Sardà, Nayade Crespo, Pilar Pique, Amparo Pascual, Clara Martí, Montserrat Fibla, Cristina Gutiérrez, Belén Lloveras, Judit Moreno-Crespi, Anna Torrent, Núria Baixeras, María Alejo, Francesc Xavier Bosch, Silvia de Sanjosé

Open Access Research article

Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor

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Open Access Research article

Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma

Yuan-Chiang Chung, Wan-Chen Wei, Shin-Han Huang, Chi-Min Shih, Chih-Ping Hsu, King-Jen Chang, Wei-Ting Chao

Open Access Research article

CDK11p58inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling

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Open Access Research article

Cancer awareness and socio-economic position: results from a population-based study in Denmark

Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Peter Vedsted

Open Access Research article

Predicting invasive breast cancer versus DCIS in different age groups

Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske, Elizabeth S Burnside

Open Access Research article

A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression

Dirk Rades, Jasmin N Evers, Volker Rudat, Amira Bajrovic, Johann H Karstens, Steven E Schild

Open Access Research article

Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells

Ke Jiang, Yingchun Li, Qiumin Zhu, Jiansheng Xu, Yupeng Wang, Wuguo Deng, Quentin Liu, Guirong Zhang, Songshu Meng

Open Access Research article

Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer

Zuli Yang, Yang Bai, Lijun Huo, Hao Chen, Jintuan Huang, Jizheng Li, Xinjuan Fan, Zihuan Yang, Lei Wang, Jianping Wang

Open Access Case report

A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity

Masataka Matsumoto, Takashi Nakayama, Daiki Inoue, Kazufumi Takamatsu, Ryo Itotani, Manabu Ishitoko, Shinko Suzuki, Minoru Sakuramoto, Yoshiaki Yuba, Osamu Yoshie, Masaya Takemura, Motonari Fukui

Open Access Research article

Differentiation of bland from neoplastic thrombus of the portal vein in patients with hepatocellular carcinoma: application of susceptibility-weighted MR imaging

Chuanming Li, Jiani Hu, Daiquan Zhou, Jun Zhao, Kuansheng Ma, Xuntao Yin, Jian Wang

Open Access Research article

A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

Pankaj G Vashi, Sadie Dahlk, Brenten Popiel, Carolyn A Lammersfeld, Carol Ireton-Jones, Digant Gupta

Open Access Research article

Regional variation in breast cancer treatment in the Netherlands and the role of external peer review: a cohort study comprising 63,516 women

Melvin J Kilsdonk, Boukje AC van Dijk, Renee Otter, Wim H van Harten, Sabine Siesling

Open Access Research article

Prognostic implication of intratumoral metabolic heterogeneity in invasive ductal carcinoma of the breast

Seung Hyun Son, Do-Hoon Kim, Chae Moon Hong, Choon-Young Kim, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn

Open Access Research article

Real world costs and cost-effectiveness of Rituximab for diffuse large B-cell lymphoma patients: a population-based analysis

Sara Khor, Jaclyn Beca, Murray Krahn, David Hodgson, Linda Lee, Michael Crump, Karen E Bremner, Jin Luo, Muhammad Mamdani, Chaim M Bell, Carol Sawka, Scott Gavura, Terrence Sullivan, Maureen Trudeau, Stuart Peacock, Jeffrey S Hoch

Open Access Research article

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen, Moul Dey

Open Access Research article

The structure and demographic correlates of cancer fear

Charlotte Vrinten, Cornelia H M van Jaarsveld, Jo Waller, Christian von Wagner, Jane Wardle

Open Access Research article

B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome

Vibeke A Ingebrigtsen, Kjetil Boye, Jahn M Nesland, Arild Nesbakken, Kjersti Flatmark, Øystein Fodstad

Open Access Case report

Blood transcript analysis and metastatic recurrent small bowel carcinoid management

Irvin M Modlin, Ignat Drozdov, Lisa Bodei, Mark Kidd

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High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

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MMP-9 expression varies according to molecular subtypes of breast cancer

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Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect

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Fibulin-1 is epigenetically down-regulated and related with bladder cancer recurrence

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Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT

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microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18

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Open Access Case report

Case report: anti-hormonal therapy in the treatment of ductal carcinoma of the parotid gland

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Characterization and drug sensitivity profiling of primary malignant mesothelioma cells from pleural effusions

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Enhanced down-regulation of ALCAM/CD166 in African-American Breast Cancer

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Ke Ji, Lin Ye, Fiona Ruge, Rachel Hargest, Malcolm D Mason, Wen G Jiang

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Differential modulation of nicotine-induced gemcitabine resistance by GABA receptor agonists in pancreatic cancer cell xenografts and in vitro

Jheelam Banerjee, Hussein AN Al-Wadei, Mohammed H Al-Wadei, Koami Dagnon, Hildegard M Schuller

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Nuclear Ep-ICD accumulation predicts aggressive clinical course in early stage breast cancer patients

Gunjan Srivastava, Jasmeet Assi, Lawrence Kashat, Ajay Matta, Martin Chang, Paul G Walfish, Ranju Ralhan

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Nitidine chloride inhibits hepatic cancer growth via modulation of multiple signaling pathways

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Open Access Research article

Estrogen receptor, progesterone receptor, interleukin-6 and interleukin-8 are variable in breast cancer and benign stem/progenitor cell populations

Robynn V Schillace, Amy M Skinner, Rodney F Pommier, Steven O’Neill, Patrick J Muller, Arpana M Naik, Juliana E Hansen, SuEllen J Pommier

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Factors modifying the risk for developing acute skin toxicity after whole-breast intensity modulated radiotherapy

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Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells

Dongdong Chen, Mingke Song, Osama Mohamad, Shan Ping Yu

Open Access Research article

High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients

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Open Access Research article

Mutational profiling of kinases in glioblastoma

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Open Access Research article

Cancer stem-like sphere cells induced from de-differentiated hepatocellular carcinoma-derived cell lines possess the resistance to anti-cancer drugs

Noriaki Hashimoto, Ryouichi Tsunedomi, Kiyoshi Yoshimura, Yusaku Watanabe, Shoichi Hazama, Masaaki Oka

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Open Access Case report

The clinical response to vemurafenib in a patient with a rare BRAF V600DK601del mutation-positive melanoma

Stéphanie Trudel, Norbert Odolczyk, Julie Dremaux, Jérôme Toffin, Aline Regnier, Henri Sevestre, Piotr Zielenkiewicz, Jean-Philippe Arnault, Brigitte Gubler

Open Access Research article

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Justyna Urban, Łukasz Kuźbicki, Grzegorz Szatkowski, Agata Stanek-Widera, Dariusz Lange, Barbara W Chwirot

Open Access Research article

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Open Access Research article

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Mauricio P Pinto, Wendy W Dye, Britta M Jacobsen, Kathryn B Horwitz

Open Access Research article

Dose-intense capecitabine, oxaliplatin and bevacizumab as first line treatment for metastatic, unresectable colorectal cancer: a multi-centre phase II study

Christopher GCA Jackson, Katrina Sharples, Paul I Thompson, Anne O’Donnell, Bridget Anne Robinson, David J Perez, Jacqui Adams, Richard Isaacs, Sanjeev Deva, Victoria A Hinder, Michael P Findlay

Open Access Research article

Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer

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Open Access Research article

Elevated preoperative peripheral blood monocyte count predicts poor prognosis for hepatocellular carcinoma after curative resection

Shun-Li Shen, Shun-Jun Fu, Xiong-Qing Huang, Bin Chen, Ming Kuang, Shao-Qiang Li, Yun-Peng Hua, Li-Jian Liang, Bao-Gang Peng

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Lymph node enlargement after definitive chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma

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Open Access Research article

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Open Access Research article

Distress, anxiety and depression in patients with brain metastases before and after radiotherapy

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Open Access Study protocol

A prospective observational study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer

Shankar Siva, Jason Callahan, Tomas Kron, Olga A Martin, Michael P MacManus, David L Ball, Rodney J Hicks, Michael S Hofman

Open Access Case report

Metachronous isolated breast metastasis from pulmonary adenocarcinoma with micropapillary component causing diagnostic challenges

Young Ju Jeong, Jin Gu Bong, Hoon Kyu Oh, Sung Hwan Park, Sung Min Kang, Sung Hwa Bae

Open Access Research article

In vivo dual targeting of the oncogenic Ether-à-go-go-1 potassium channel by calcitriol and astemizole results in enhanced antineoplastic effects in breast tumors

Janice García-Quiroz, Rocío García-Becerra, Nancy Santos-Martínez, David Barrera, David Ordaz-Rosado, Euclides Avila, Ali Halhali, Octavio Villanueva, Maŕa J Ibarra-Sánchez, José Esparza-López, Armando Gamboa-Domínguez, Javier Camacho, Fernando Larrea, Lorenza Díaz

Open Access Research article

MicroRNA expression as risk biomarker of breast cancer metastasis: a pilot retrospective case-cohort study

Augusto LF Marino, Adriane F Evangelista, René AC Vieira, Taciane Macedo, Ligia M Kerr, Lucas Faria Abrahão-Machado, Adhemar Longatto-Filho, Henrique CS Silveira, Marcia MC Marques

Open Access Study protocol

The CAIRO4 study: the role of surgery of the primary tumour with few or absent symptoms in patients with synchronous unresectable metastases of colorectal cancer – a randomized phase III study of the Dutch Colorectal Cancer Group (DCCG)

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Open Access Study protocol

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

Martin Sebastian, Alexandros Papachristofilou, Christian Weiss, Martin Früh, Richard Cathomas, Wolfgang Hilbe, Thomas Wehler, Gerd Rippin, Sven D Koch, Birgit Scheel, Mariola Fotin-Mleczek, Regina Heidenreich, Karl-Josef Kallen, Ulrike Gnad-Vogt, Alfred Zippelius

Open Access Research article

ERβ1: characterization, prognosis, and evaluation of treatment strategies in ERα-positive and -negative breast cancer

Jordan M Reese, Vera J Suman, Malayannan Subramaniam, Xianglin Wu, Vivian Negron, Anne Gingery, Kevin S Pitel, Sejal S Shah, Heather E Cunliffe, Ann E McCullough, Barbara A Pockaj, Fergus J Couch, Janet E Olson, Carol Reynolds, Wilma L Lingle, Thomas C Spelsberg, Matthew P Goetz, James N Ingle, John R Hawse

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Development and validation of a clinical prediction rule to identify suspected breast cancer: a prospective cohort study

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Open Access Research article

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Open Access Research article

Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer

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Open Access Research article

Characterization of β2-microglobulin expression in different types of breast cancer

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Open Access Research article

Reversible inhibition of lysine specific demethylase 1 is a novel anti-tumor strategy for poorly differentiated endometrial carcinoma

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Lactate transporters and vascular factors in HPV-induced squamous cell carcinoma of the uterine cervix

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Cyclin-dependent kinase-specific activity predicts the prognosis of stage I and stage II non-small cell lung cancer

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Assessing quality of life on the day of chemotherapy administration underestimates patients’ true symptom burden

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IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort

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Open Access Research article

Bevacizumab in first-line treatment of elderly patients with metastatic colorectal cancer: German community-based observational cohort study results

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Open Access Case report

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Open Access Research article

Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance

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Chemically induced mouse liver tumors are resistant to treatment with atorvastatin

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Open Access Research article

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GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva

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Racial differences in mantle cell lymphoma in the United States

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Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells

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Meta-analysis shows that circulating tumor cells including circulating microRNAs are useful to predict the survival of patients with gastric cancer

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Open Access Research article

Comparison of the clinical courses and chemotherapy outcomes in metastatic colorectal cancer patients with and without active Mycobacterium tuberculosis or Mycobacterium kansasiiinfection: a retrospective study

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Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis

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Embelin inhibits TNF-α converting enzyme and cancer cell metastasis: molecular dynamics and experimental evidence

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Open Access Research article

High focal adhesion kinase expression in breast carcinoma is associated with lymphovascular invasion and triple-negative phenotype

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Open Access Research article

Diagnosis and staging of superficial esophageal precursor based on pre-endoscopic resection system comparable to endoscopic resection

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Open Access Research article

Increased incidence of head and neck cancer in liver transplant recipients: a meta-analysis

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Open Access Research article

DNA repair deficiency in peripheral blood lymphocytes of endometrial cancer patients with a family history of cancer

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Open Access Research article

Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology

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Open Access Research article

The magnitude and characteristics of the population of cancer survivors: using population-based estimates of cancer prevalence to inform service planning for survivorship care

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Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes

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Open Access Research article

Safety and effectiveness of vinflunine in patients with metastatic transitional cell carcinoma of the urothelial tract after failure of one platinum-based systemic therapy in clinical practice

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Open Access Research article

A simple way to measure the burden of interval cancers in breast cancer screening

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Open Access Study protocol

Adjuvant therapy with high dose vitamin D following primary treatment of melanoma at high risk of recurrence: a placebo controlled randomised phase II trial (ANZMTG 02.09 Mel-D)

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Open Access Research article

Elevated CXCL1 expression in breast cancer stroma predicts poor prognosis and is inversely associated with expression of TGF-β signaling proteins

An Zou, Diana Lambert, Henry Yeh, Ken Yasukawa, Fariba Behbod, Fang Fan, Nikki Cheng

Open Access Research article

FTY720 inhibits proliferation and epithelial-mesenchymal transition in cholangiocarcinoma by inactivating STAT3 signaling

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Open Access Research article

Prospective genetic profiling of squamous cell lung cancer and adenosquamous carcinoma in Japanese patients by multitarget assays

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Open Access Research article

Bmi1 regulates self-renewal and epithelial to mesenchymal transition in breast cancer cells through Nanog

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Open Access Research article

Does the time between CT scan and chemotherapy increase the risk of acute adverse reactions to iodinated contrast media in cancer patients?

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Open Access Research article

Comparison of concurrent chemoradiotherapy versus neoadjuvant chemotherapy followed by radiation in patients with advanced nasopharyngeal carcinoma in endemic area: experience of 128 consecutive cases with 5 year follow-up

Shang-Yin Wu, Yuan-Hua Wu, Ming-Wei Yang, Wei-Ting Hsueh, Jenn-Ren Hsiao, Sen-Tien Tsai, Kwang-Yu Chang, Jeffrey S Chang, Chia-Jui Yen

Open Access Research article

Descriptive Epidemiology in Mexican children with cancer under an open national public health insurance program

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Open Access Research article

A multicenter phase II study of everolimus in patients with progressive unresectable adenoid cystic carcinoma

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Open Access Research article

Combined use of the automated breast volume scanner and the US elastography for the differentiation of benign from malignant lesions of the breast

Chaoli Xu, Shuping Wei, Yingdong Xie, Xiaoxiang Guan, Ninghua Fu, Pengfei Huang, Bin Yang

Open Access Research article

Evaluation of superparamagnetic iron oxide-polymer composite microcapsules for magnetic resonance-guided high-intensity focused ultrasound cancer surgery

Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang, Haitao Ran

Open Access Research article

Cytosolic galectin-7 impairs p53 functions and induces chemoresistance in breast cancer cells

Andrée-Anne Grosset, Marilyne Labrie, Donald Gagné, Maria-Claudia Vladoiu, Louis Gaboury, Nicolas Doucet, Yves St-Pierre

Open Access Research article

Knockdown of anterior gradient 2 expression extenuates tumor-associated phenotypes of SNU-478 ampulla of Vater cancer cells

Su Jin Kim, Suyeon Jun, Hee-Yeon Cho, Dong Chul Lee, Young Il Yeom, Jong Hyeok Kim, Dongchul Kang

Open Access Study protocol

The Initiative to Maximize Progress in Adolescent and Young Adult Cancer Therapy (IMPACT) Cohort Study: a population-based cohort of young Canadians with cancer

Nancy N Baxter, Corinne Daly, Sumit Gupta, Jason D Pole, Rinku Sutradhar, Mark L Greenberg, Paul C Nathan

Open Access Research article

Oxaliplatin-based versus irinotecan-based hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis from appendiceal and colorectal cancer: a retrospective analysis

Gabriel Glockzin, Michael Gerken, Sven A Lang, Monika Klinkhammer-Schalke, Pompiliu Piso, Hans J Schlitt

Open Access Research article

Differential regulation of MAGE-A1 promoter activity by BORIS and Sp1, both interacting with the TATA binding protein

Heidi Schwarzenbach, Corinna Eichelser, Bettina Steinbach, Josefine Tadewaldt, Klaus Pantel, Victor Lobanenkov, Dmitri Loukinov

Open Access Research article

Long-term tumor remission under trastuzumab treatment for HER2 positive metastatic breast cancer – results from the HER-OS patient registry

Isabell Witzel, Volkmar Müller, Wolfgang Abenhardt, Manfred Kaufmann, Winfried Schoenegg, Andreas Schneeweis, Fritz Jänicke

Open Access Research article

Treatment of colorectal liver metastases in Germany: a ten-year population-based analysis of 5772 cases of primary colorectal adenocarcinoma

Christina Hackl, Peter Neumann, Michael Gerken, Martin Loss, Monika Klinkhammer-Schalke, Hans J Schlitt

Open Access Research article

Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy

Edwin Choy, James E Butrynski, David C Harmon, Jeffrey A Morgan, Suzanne George, Andrew J Wagner, David D’Adamo, Gregory M Cote, Yael Flamand, Cyril H Benes, Daniel A Haber, Jose M Baselga, George D Demetri

Open Access Research article

Clinical approaches to treating papillary squamous cell carcinoma of the uterine cervix

Michikazu Nagura, Masafumi Koshiyama, Noriomi Matsumura, Aki Kido, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Ken Yamaguchi, Yoshiki Mikami, Ikuo Konishi

Open Access Research article

Prophylactic cranial irradiation for patients with small-cell lung cancer: a systematic review of the literature with meta-analysis

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Open Access Research article

Association between insulin-like growth factor-1 receptor (IGF1R) negativity and poor prognosis in a cohort of women with primary breast cancer

Kristina E Aaltonen, Ann H Rosendahl, Hans Olsson, Per Malmström, Linda Hartman, Mårten Fernö

Open Access Research article

Repeat polymorphisms in ESR2 and ARand colorectal cancer risk and prognosis: results from a German population-based case-control study

Anja Rudolph, Hong Shi, Asta Försti, Michael Hoffmeister, Juan Sainz, Lina Jansen, Kari Hemminki, Hermann Brenner, Jenny Chang-Claude

Open Access Research article

MicroRNA-21 and the clinical outcomes of various carcinomas: a systematic review and meta-analysis

Wenjia Wang, Jinhui Li, Wei Zhu, Chen Gao, RuiJingfang Jiang, Wenxue Li, Qiansheng Hu, Bo Zhang

Open Access Research article

Tumour suppressor gene methylation and cervical cell folate concentration are determinants of high-risk human papillomavirus persistence: a nested case control study

Janet E Flatley, Alexandra Sargent, Henry C Kitchener, Jean M Russell, Hilary J Powers

Open Access Research article

Involvement of adiponectin in early stage of colorectal carcinogenesis

Chung Hyun Tae, Seong-Eun Kim, Sung-Ae Jung, Yang-Hee Joo, Ki-Nam Shim, Hye-Kyung Jung, Tae Hun Kim, Min-Sun Cho, Kwang Ho Kim, Joung Sook Kim

Open Access Research article

Men’s knowledge and attitudes towards dietary prevention of a prostate cancer diagnosis: a qualitative study

Jeremy P Horwood, Kerry NL Avery, Chris Metcalfe, Jenny L Donovan, Freddie C Hamdy, David E Neal, J Athene Lane

Open Access Research article

ROCK1 as a novel prognostic marker in vulvar cancer

Erica M Akagi, André M Lavorato-Rocha, Beatriz de Melo Maia, Iara S Rodrigues, Kátia C Carvalho, Monica M Stiepcich, Glauco Baiocchi, Yukie Sato-Kuwabara, Silvia R Rogatto, Fernando A Soares, Rafael M Rocha

Open Access Research article

Different protein expression associated with chemotherapy response in oropharyngeal cancer according to HPV status

Min-Jee Kim, Myung-Seo Ki, Karham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Woo-Kyun Bae, Ik-Joo Chung, Dong-Hoon Lee, Joon-Kyoo Lee, Tae-Mi Yoon, Sang-Chul Lim, Woong-Ki Chung, Jae-Uk Jeong, Hoi-Soon Lim, Yoo-Duk Choi, Sang-Hee Cho

Open Access Research article

The clinical and biological significance of STAT1 in esophageal squamous cell carcinoma

Ying Zhang, Ommoleila Molavi, Min Su, Raymond Lai

Open Access Research article

RNA-seq profiling of a radiation resistant and radiation sensitive prostate cancer cell line highlights opposing regulation of DNA repair and targets for radiosensitization

Arabella Young, Rachael Berry, Adele F Holloway, Nicholas B Blackburn, Joanne L Dickinson, Marketa Skala, Jessica L Phillips, Kate H Brettingham-Moore

Open Access Research article

MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression

Shih-Feng Cho, Yuli Christine Chang, Chao-Sung Chang, Sheng-Fung Lin, Yi-Chang Liu, Hui-Hua Hsiao, Jan-Gowth Chang, Ta-Chih Liu

Open Access Research article

Effects of insulin on human pancreatic cancer progression modeled in vitro

Michelle T Chan, Gareth E Lim, Søs Skovsø, Yu Hsuan Carol Yang, Tobias Albrecht, Emilyn U Alejandro, Corinne A Hoesli, James M Piret, Garth L Warnock, James D Johnson

Open Access Research article

Plasmalemmal Vesicle Associated Protein (PLVAP) as a therapeutic target for treatment of hepatocellular carcinoma

Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang, Kuo-Jang Kao

Open Access Research article

Partial hepatectomy for liver metastases from nasopharyngeal carcinoma: a comparative study and review of the literature

Jun Huang, Qijiong Li, Yun Zheng, Jingxian Shen, Binkui Li, Ruhai Zou, Jianping Wang, Yunfei Yuan

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BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients

Jing Chen, Fang Guo, Xin Shi, Lihua Zhang, Aifeng Zhang, Hui Jin, Youji He

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Advantages of intensity modulated radiotherapy in recurrent T1-2 nasopharyngeal carcinoma: a retrospective study

Sufang Qiu, Jun Lu, Wei Zheng, Luying Xu, Shaojun Lin, Chaobin Huang, Yuanji Xu, Lingling Huang, Jianji Pan

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Multimodal therapy in treatment of rectal cancer is associated with improved survival and reduced local recurrence - a retrospective analysis over two decades

Armin Wiegering, Christoph Isbert, Ulrich A Dietz, Volker Kunzmann, Sabine Ackermann, Alexander Kerscher, Uwe Maeder, Michael Flentje, Nicolas Schlegel, Joachim Reibetanz, Christoph-Thomas Germer, Ingo Klein

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Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber ‘cell highways’

Mark Tyler Nelson, Aaron Short, Sara L Cole, Amy C Gross, Jessica Winter, Tim D Eubank, John J Lannutti

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Multicenter phase II study of Apatinib in non-triple-negative metastatic breast cancer

Xichun Hu, Jun Cao, Wenwei Hu, Changping Wu, Yueyin Pan, Li Cai, Zhongsheng Tong, Shusen Wang, Jin Li, Zhonghua Wang, Biyun Wang, Xiaoyu Chen, Hao Yu

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Gender dimorphism and age of onset in malignant peripheral nerve sheath tumor preclinical models and human patients

Elizabeth Shurell, Linh M Tran, Jonathan Nakashima, Kathleen B Smith, Brenna M Tam, Yunfeng Li, Sarah M Dry, Noah Federman, William D Tap, Hong Wu, Fritz C Eilber

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Emerging markers of cachexia predict survival in cancer patients

Patrizia Mondello, Antonio Lacquaniti, Stefania Mondello, Davide Bolignano, Vincenzo Pitini, Carmela Aloisi, Michele Buemi

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Platinum sensitivity and CD133 expression as risk and prognostic predictors of central nervous system metastases in patients with epithelial ovarian cancer

Bo-lin Liu, Shu-juan Liu, Andrius Baskys, Hong Cheng, Ying Han, Chao Xie, Hui Song, Jia Li, Xiao-yan Xin

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An increased risk of epithelial ovarian cancer in Taiwanese women with a new surgico-pathological diagnosis of endometriosis

Kuan-Chin Wang, Wen-Hsun Chang, Wen-Ling Lee, Nicole Huang, Hsin-Yi Huang, Ming-Shyen Yen, Chao-Yu Guo, Peng-Hui Wang

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Non-small cell lung cancer with EML4-ALKtranslocation in Chinese male never-smokers is characterized with early-onset

Yongjun Guo, Jie Ma, Xiaodong Lyu, Hai Liu, Bing Wei, Jiuzhou Zhao, Shuang Fu, Lu Ding, Jihong Zhang

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Global gene expression profiling identifies ALDH2, CCNE1 and SMAD3 as potential prognostic markers in upper tract urothelial carcinoma

Song Wu, Jiahao Chen, Pei Dong, Shiqiang Zhang, Yingying He, Liang Sun, Jialou Zhu, Yanbing Cheng, Xianxin Li, Aifa Tang, Yi Huang, Yaoting Gui, Chunxiao Liu, Guosheng Yang, Fangjian Zhou, Zhiming Cai, Rongfu Wang

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Ethnic differences in timely adjuvant chemotherapy and radiation therapy for breast cancer in New Zealand: a cohort study

Sanjeewa Seneviratne, Ian Campbell, Nina Scott, Marion Kuper-Hommel, Glenys Round, Ross Lawrenson

Open Access Research article

Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms

Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust, Leszek Wojnowski

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Impact of preoperative anemia on relapse and survival in breast cancer patients

YingJun Zhang, YuYang Chen, DongTai Chen, Yu Jiang, Wan Huang, HanDong Ouyang, Wei Xing, MuSheng Zeng, XiaoMing Xie, Weian Zeng

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Elevated levels of plasma D-dimer predict a worse outcome in patients with nasopharyngeal carcinoma

Wen-Hui Chen, Lin-Quan Tang, Feng-Wei Wang, Chang-Peng Li, Xiao-Peng Tian, Xiao-Xia Huang, Shi-Juan Mai, Yi-Ji Liao, Hai-Xia Deng, Qiu-Yan Chen, Huai Liu, Lu Zhang, Shan-Shan Guo, Li-Ting Liu, Shu-Mei Yan, Chao-Feng Li, Jing-Ping Zhang, Qing Liu, Xue-Wen Liu, Li-Zhi Liu, Hai-Qiang Mai, Mu-Sheng Zeng, Dan Xie

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Fluoxetine modulates breast cancer metastasis to the brain in a murine model

Yuriy Shapovalov, Martha Zettel, Sara C Spielman, Stacy A Amico-Ruvio, Emily A Kelly, Grayson O Sipe, Ian M Dickerson, Ania K Majewska, Edward B Brown

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Canonical Notch signalling is inactive in urothelial carcinoma

Annemarie Greife, Silvia Jankowiak, Jochen Steinbring, Parvaneh Nikpour, Günter Niegisch, Michèle J Hoffmann, Wolfgang A Schulz

Open Access Research article

Reduced expression of p21-activated protein kinase 1 correlates with poor histological differentiation in pancreatic cancer

Juan Han, Feng Wang, Shu-qiang Yuan, Ying Guo, Zhao-lei Zeng, Li-ren Li, Jing Yang, De-sen Wang, Mei-yuan Liu, Han Zhao, Kai-yan Liu, Jian-wei Liao, Qing-feng Zou, Rui-hua Xu

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Histopathology-based prognostic score is independent prognostic factor of gastric carcinoma

Zhi Zhu, Xuren Sun, Jinou Wang, Zhe Sun, Zhenning Wang, Xinyu Zheng, Huimian Xu

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A DNA aptamer with high affinity and specificity for molecular recognition and targeting therapy of gastric cancer

Hong-Yong Cao, Ai-Hua Yuan, Wei Chen, Xue-Song Shi, Yi Miao

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Survival in overweight patients with advanced pancreatic carcinoma: a multicentre cohort study

Benjamin Kasenda, Annatina Bass, Dieter Koeberle, Bernhard Pestalozzi, Markus Borner, Richard Herrmann, Lorenz Jost, Andreas Lohri, Viviane Hess

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MEK1 is associated with carboplatin resistance and is a prognostic biomarker in epithelial ovarian cancer

Zsófia Pénzváltó, András Lánczky, Julianna Lénárt, Nóra Meggyesházi, Tibor Krenács, Norbert Szoboszlai, Carsten Denkert, Imre Pete, Balázs Győrffy

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Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy

Jaeyoung Cho, Sung-Jun Ko, Se Joong Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Jae Ho Lee, Choon-Taek Lee

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Nasopharyngeal carcinoma with paranasal sinus invasion: the prognostic significance and the evidence-based study basis of its T-staging category according to the AJCC staging system

Li Tian, Yi-Zhuo Li, Yun-Xian Mo, Li-Zhi Liu, Chuan-Miao Xie, Xue-Xia Liang, Xiao Gong, Wei Fan

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Radiation therapy of anal canal cancer: from conformal therapy to volumetric modulated arc therapy

Angelo Tozzi, Luca Cozzi, Cristina Iftode, Annamaria Ascolese, Maria Concetta Campisi, Elena Clerici, Tiziana Comito, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Pietro Mancosu, Piera Navarria, Stefano Tomatis, Elisa Villa, Marta Scorsetti

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DCE-MRI assessment of the effect of Epstein-Barr virus-encoded latent membrane protein-1 targeted DNAzyme on tumor vasculature in patients with nasopharyngeal carcinomas

Wei-Hua Liao, Li-Fang Yang, Xiao-Yu Liu, Gao-Feng Zhou, Wu-Zhong Jiang, Bob-Lei Hou, Lun-Quan Sun, Ya Cao, Xiao-Yi Wang

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Nutrition and lung cancer: a case control study in Iran

Mostafa Hosseini, Parisa Adimi Naghan, Ali Moghadas Jafari, Mahmoud Yousefifard, Shervin Taslimi, Kian Khodadad, Forouzan Mohammadi, Makan Sadr, Mansour Rezaei, Esmaeil Mortaz, Mohammad Reza Masjedi

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Transcatheter arterial chemoembolization combined with radiofrequency ablation delays tumor progression and prolongs overall survival in patients with intermediate (BCLC B) hepatocellular carcinoma

Xin Yin, Lan Zhang, Yan-Hong Wang, Bo-Heng Zhang, Yu-Hong Gan, Ning-Lin Ge, Yi Chen, Li-Xin Li, Zheng-Gang Ren

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A DNA repair variant in POLQ (c.-1060A > G) is associated to hereditary breast cancer patients: a case–control study

Ana Paula Carneiro Brandalize, Lavínia Schüler-Faccini, Jean-Sébastien Hoffmann, Maira Caleffi, Christophe Cazaux, Patricia Ashton-Prolla

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Fas Activated Serine-Threonine Kinase Domains 2 (FASTKD2) mediates apoptosis of breast and prostate cancer cells through its novel FAST2 domain

Sharmistha Das, Kay T Yeung, Muktar A Mahajan, Herbert H Samuels

Open Access Research article

Prognostic and diagnostic value of epithelial to mesenchymal transition markers in pulmonary neuroendocrine tumors

Jose A Galván, Aurora Astudillo, Aitana Vallina, Guillermo Crespo, Maria Victoria Folgueras, Maria Victoria González

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Localization of phosphorylated ErbB1-4 and heregulin in colorectal cancer

Keigo Mitsui, Masaoki Yonezawa, Atsushi Tatsuguchi, Seiichi Shinji, Katya Gudis, Shu Tanaka, Shunji Fujimori, Choitsu Sakamoto

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Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases

Laura S Jiwa, Paul J van Diest, Laurien D Hoefnagel, Jelle Wesseling, Pieter Wesseling, Cathy B Moelans

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Validation of COL11A1/procollagen 11A1 expression in TGF-β1-activated immortalised human mesenchymal cells and in stromal cells of human colon adenocarcinoma

José A Galván, Jorge García-Martínez, Fernando Vázquez-Villa, Marcos García-Ocaña, Carmen García-Pravia, Primitiva Menéndez-Rodríguez, Carmen González-del Rey, Luis Barneo-Serra, Juan R de los Toyos

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High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs

Daniela D’Angelo, Paula Mussnich, Roberta Rosa, Roberto Bianco, Giampaolo Tortora, Alfredo Fusco

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Chromosomal alterations in exfoliated urothelial cells from bladder cancer cases and healthy men: a prospective screening study

Nadine Bonberg, Beate Pesch, Thomas Behrens, Georg Johnen, Dirk Taeger, Katarzyna Gawrych, Christian Schwentner, Harald Wellhäußer, Matthias Kluckert, Gabriele Leng, Michael Nasterlack, Christoph Oberlinner, Arnulf Stenzl, Thomas Brüning

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Impact of late toxicities on quality of life for survivors of nasopharyngeal carcinoma

Wen-Ling Tsai, Tai-Lin Huang, Kuan-Cho Liao, Hui-Ching Chuang, Yu-Tsai Lin, Tsair-Fwu Lee, Hsuan-Ying Huang, Fu-Min Fang

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High miR-449b expression in prostate cancer is associated with biochemical recurrence after radical prostatectomy

Martin Mørck Mortensen, Søren Høyer, Torben Falck Ørntoft, Karina Dalsgaard Sørensen, Lars Dyrskjøt, Michael Borre

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FOXP1inhibits cell growth and attenuates tumorigenicity of neuroblastoma

Sandra Ackermann, Hayriye Kocak, Barbara Hero, Volker Ehemann, Yvonne Kahlert, André Oberthuer, Frederik Roels, Jessica Theißen, Margarete Odenthal, Frank Berthold, Matthias Fischer

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Increased coagulation activity and genetic polymorphisms in the F5, F10 and EPCRgenes are associated with breast cancer: a case-control study

Mari Tinholt, Marte Kathrine Viken, Anders Erik Dahm, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Øystein Garred, Anne-Lise Børresen-Dale, Anne Flem Jacobsen, Vessela Kristensen, Ida Bukholm, Rolf Kåresen, Ellen Schlichting, Grethe Skretting, Benedicte Alexandra Lie, Per Morten Sandset, Nina Iversen

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Diagnostic value of retrospective PET-MRI fusion in head-and-neck cancer

Denys J Loeffelbein, Michael Souvatzoglou, Veronika Wankerl, Julia Dinges, Lucas M Ritschl, Thomas Mücke, Anja Pickhard, Matthias Eiber, Markus Schwaiger, Ambros J Beer

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Prognostic information of serial plasma osteopontin measurement in radiotherapy of non-small-cell lung cancer

Christian Ostheimer, Matthias Bache, Antje Güttler, Thomas Reese, Dirk Vordermark

Open Access Research article

1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer

Markus Mayrhofer, Hanna Göransson Kultima, Helgi Birgisson, Magnus Sundström, Lucy Mathot, Karolina Edlund, Björn Viklund, Tobias Sjöblom, Johan Botling, Patrick Micke, Lars Påhlman, Bengt Glimelius, Anders Isaksson

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Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86

John P Alao, Sona Michlikova, Peter Dinér, Morten Grøtli, Per Sunnerhagen

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Oxidative stress in susceptibility to breast cancer: study in Spanish population

Patricia Rodrigues, Griselda de Marco, Jessica Furriol, Maria Luisa Mansego, Mónica Pineda-Alonso, Anna Gonzalez-Neira, Juan Carlos Martin-Escudero, Javier Benitez, Ana Lluch, Felipe J Chaves, Pilar Eroles

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Biweekly cetuximab in combination with FOLFOX-4 in the first-line treatment of wild-type KRASmetastatic colorectal cancer: final results of a phase II, open-label, clinical trial (OPTIMIX-ACROSS Study)

Julen Fernandez-Plana, Carlos Pericay, Guillermo Quintero, Vicente Alonso, Antonieta Salud, Miguel Mendez, Mercedes Salgado, Eugeni Saigi, Luis Cirera

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Breast and prostate cancer: an analysis of common epidemiological features in mortality trends in Spain

Gonzalo López-Abente, Sergio Mispireta, Marina Pollán

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Hypoxia, blood flow and metabolism in squamous-cell carcinoma of the head and neck: correlations between multiple immunohistochemical parameters and PET

Tove J Grönroos, Kaisa Lehtiö, Karl-Ove Söderström, Pauliina Kronqvist, Jukka Laine, Olli Eskola, Tapio Viljanen, Reidar Grénman, Olof Solin, Heikki Minn

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Constitutive activation of the ERK pathway in melanoma and skin melanocytes in Grey horses

Lin Jiang, Cécile Campagne, Elisabeth Sundström, Pedro Sousa, Saima Imran, Monika Seltenhammer, Gerli Pielberg, Mats J Olsson, Giorgia Egidy, Leif Andersson, Anna Golovko

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MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway

Cheng Du, Xiaomin Yi, Wenchao Liu, Tao Han, Zhaozhe Liu, Zhenyu Ding, Zhendong Zheng, Ying Piao, Jianlin Yuan, Yaling Han, Manjiang Xie, Xiaodong Xie

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A case-control study of glycemic index, glycemic load and dietary fiber intake and risk of adenocarcinomas and squamous cell carcinomas of the esophagus: the Australian Cancer Study

Petra H Lahmann, Torukiri I Ibiebele, Penelope M Webb, Christina M Nagle, David C Whiteman

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Which is the best postoperative chemotherapy regimen in patients with rectal cancer after neoadjuvant therapy?

Peng Gao, Yong-xi Song, Jing-xu Sun, Xiao-wan Chen, Ying-ying Xu, Jun-hua Zhao, Xuan-zhang Huang, Hui-mian Xu, Zhen-ning Wang

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Eligibility criteria for intraoperative radiotherapy for breast cancer: study employing 12,025 patients treated in two cohorts

Amira Ziouèche-Mottet, Gilles Houvenaeghel, Jean Marc Classe, Jean Rémi Garbay, Sylvia Giard, Hélène Charitansky, Monique Cohen, Catherine Belichard, Christelle Faure, Elisabeth Chéreau Ewald, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Agnès Tallet, Marie Bannier, Mathieu Minsat, Eric Lambaudie, Michel Resbeut

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Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1

Meghan L Rudd, Hassan Mohamed, Jessica C Price, Andrea J O’Hara, Matthieu Le Gallo, Mary Ellen Urick, Pedro Cruz, Suiyuan Zhang, Nancy F Hansen, Andrew K Godwin, Dennis C Sgroi, Tyra G Wolfsberg, James C Mullikin, Maria J Merino, Daphne W Bell

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URG4 overexpression is correlated with cervical cancer progression and poor prognosis in patients with early-stage cervical cancer

Lan Zhang, He Huang, Longjuan Zhang, Teng Hou, Shu Wu, Qidan Huang, Libing Song, Jihong Liu

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Multiple pregnancies, hepatitis C, and risk for hepatocellular carcinoma in Egyptian women

Sania Amr, Emily A Iarocci, Ghada R Nasr, Doa’a Saleh, Jan Blancato, Kirti Shetty, Christopher A Loffredo

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Calmodulin antagonists induce cell cycle arrest and apoptosis in vitro and inhibit tumor growth in vivo in human multiple myeloma

Shigeyuki Yokokura, Saki Yurimoto, Akihito Matsuoka, Osamu Imataki, Hiroaki Dobashi, Shuji Bandoh, Takuya Matsunaga

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The prevalence of estrogen receptor-negative breast cancer in Ethiopia

Eva Johanna Kantelhardt, Assefa Mathewos, Abreha Aynalem, Tigeneh Wondemagegnehu, Ahmedin Jemal, Martina Vetter, Erdme Knauf, Anne Reeler, Solomon Bogale, Christoph Thomssen, Andreas Stang, Tufa Gemechu, Pietro Trocchi, Bekuretsion Yonas

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Inhibition of STAT3-interacting protein 1 (STATIP1) promotes STAT3 transcriptional up-regulation and imatinib mesylate resistance in the chronic myeloid leukemia

André L Mencalha, Stephany Corrêa, Daniela Salles, Bárbara Du Rocher, Marcelo F Santiago, Eliana Abdelhay

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CD30 expression is a novel prognostic indicator in extranodal natural killer/T-cell lymphoma, nasal type

Pengfei Li, Li Jiang, Xinke Zhang, Jun Liu, Hua Wang

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Overexpression of E2F1 in human gastric carcinoma is involved in anti-cancer drug resistance

Lin-Hai Yan, Wei-Yuan Wei, Wen-Long Cao, Xiao-Shi Zhang, Yu-Bo Xie, Qiang Xiao

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Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice

Sandra Burghoff, Xuan Gong, Claudia Viethen, Christoph Jacoby, Ulrich Flögel, Sabine Bongardt, Anne Schorr, Andreas Hippe, Bernhard Homey, Jürgen Schrader

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Clinical characteristics and prognostic factors of bone lymphomas: focus on the clinical significance of multifocal bone involvement by primary bone large B-cell lymphomas

Huanwen Wu, Marilyn M Bui, Douglas G Leston, Haipeng Shao, Lubomir Sokol, Eduardo M Sotomayor, Ling Zhang

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Epigenetic inactivation of ST6GAL1 in human bladder cancer

Pia Antony, Michael Rose, Axel Heidenreich, Ruth Knüchel, Nadine T Gaisa, Edgar Dahl

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Recurrent CYP2C19 deletion allele is associated with triple-negative breast cancer

Anna Tervasmäki, Robert Winqvist, Arja Jukkola-Vuorinen, Katri Pylkäs

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Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model

Lotte B Bertelsen, Anja B Bohn, Yuan Yuan Shen, Lise Falborg, Hans Stødkilde-Jørgensen, Michael R Horsman

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An epidemiological study assessing the prevalence of human papillomavirus types in women in the Kingdom of Bahrain

Khairya Moosa, Adel Salman Alsayyad, Wim Quint, Kusuma Gopala, Rodrigo DeAntonio

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Increased risk of everolimus-associated acute kidney injury in cancer patients with impaired kidney function

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Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma

Niamh Lynam-Lennon, Ruth Connaughton, Eibhlin Carr, Ann-Marie Mongan, Naoimh J O’Farrell, Richard K Porter, Lorraine Brennan, Graham P Pidgeon, Joanne Lysaght, John V Reynolds, Jacintha O’Sullivan

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Inclusion of KI67 significantly improves performance of the PREDICT prognostication and prediction model for early breast cancer

Gordon C Wishart, Emad Rakha, Andrew Green, Ian Ellis, Hamid Raza Ali, Elena Provenzano, Fiona M Blows, Carlos Caldas, Paul DP Pharoah

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MicroRNA-1269 promotes proliferation in human hepatocellular carcinoma via downregulation of FOXO1

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Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer

Maryna Veremieva, Liudmyla Kapustian, Antonina Khoruzhenko, Valery Zakharychev, Boris Negrutskii, Anna El’skaya

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The impact of a cancer diagnosis on weight change: findings from prospective, population-based cohorts in the UK and the US

Sarah E Jackson, Kate Williams, Andrew Steptoe, Jane Wardle

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Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists

Ana-Luisa Silva, Sarah N Dawson, Mark J Arends, Kiran Guttula, Nigel Hall, Ewen A Cameron, Tim H-M Huang, James D Brenton, Simon Tavaré, Mariann Bienz, Ashraf EK Ibrahim

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Quantitative assessment of the asphericity of pretherapeutic FDG uptake as an independent predictor of outcome in NSCLC

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The survival and the long-term trends of patients with gastric cancer in Shanghai, China

Leizhen Zheng, Chunxiao Wu, Pan Xi, Meiling Zhu, Li Zhang, Siyu Chen, Xiaoping Li, Jianchun Gu, Ying Zheng

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Elevation of MMP-9 and IDO induced by pancreatic cancer cells mediates natural killer cell dysfunction

Yun-Peng Peng, Jing-Jing Zhang, Wen-biao Liang, Min Tu, Zi-Peng Lu, Ji-Shu Wei, Kui-Rong Jiang, Wen-Tao Gao, Jun-Li Wu, Ze-Kuan Xu, Yi Miao, Yi Zhu

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Triple negative breast cancers express receptors for LHRH and are potential therapeutic targets for cytotoxic LHRH-analogs, AEZS 108 and AEZS 125

Stephan Seitz, Stefan Buchholz, Andrew Victor Schally, Florian Weber, Monika Klinkhammer-Schalke, Elisabeth C Inwald, Roberto Perez, Ferenc G Rick, Luca Szalontay, Florian Hohla, Sabine Segerer, Chui Wai Kwok, Olaf Ortmann, Jörg Bernhard Engel

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Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis

Marsha M Thomas, Yaqing Zhang, Esha Mathew, Kevin T Kane, Ivan Maillard, Marina Pasca di Magliano

Open Access Study protocol

Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid - short RadioTherapy - rectum 3rd trial)

Antonio Avallone, Maria Carmela Piccirillo, Paolo Delrio, Biagio Pecori, Elena Di Gennaro, Luigi Aloj, Fabiana Tatangelo, Valentina D’Angelo, Cinzia Granata, Ernesta Cavalcanti, Nicola Maurea, Piera Maiolino, Franco Bianco, Massimo Montano, Lucrezia Silvestro, Manuela Terranova Barberio, Maria Serena Roca, Massimo Di Maio, Pietro Marone, Gerardo Botti, Antonella Petrillo, Gennaro Daniele, Secondo Lastoria, Vincenzo R Iaffaioli, Giovanni Romano, Corradina Caracò, Paolo Muto, Ciro Gallo, Francesco Perrone, Alfredo Budillon

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A case–control study of pre-operative levels of serum neutrophil gelatinase-associated lipocalin and other potential inflammatory markers in colorectal cancer

Laurence Duvillard, Pablo Ortega-Deballon, Abderrahmane Bourredjem, Marie-Lorraine Scherrer, Georges Mantion, Jean-Baptiste Delhorme, Sophie Deguelte-Lardière, Jean-Michel Petit, Claire Bonithon-Kopp

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Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

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Number of tumor foci predicts prognosis in papillary thyroid cancer

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MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b

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Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case–control study

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Radiotherapy treatment of adrenal gland metastases from hepatocellular carcinoma: clinical features and prognostic factors

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microRNA-141 inhibits cell proliferation and invasion and promotes apoptosis by targeting hepatocyte nuclear factor-3β in hepatocellular carcinoma cells

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Deep Sequencing the microRNA profile in rhabdomyosarcoma reveals down-regulation of miR-378 family members

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Interplay between 3′-UTR polymorphisms in the vascular endothelial growth factor (VEGF) gene and metabolic syndrome in determining the risk of colorectal cancer in Koreans

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S-1 plus oxaliplatin versus capecitabine plus oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: updated results from a phase 3 trial

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Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation

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INTRAGO: intraoperative radiotherapy in glioblastoma multiforme – a Phase I/II dose escalation study

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Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein

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Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening

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SC-III3, a novel scopoletin derivative, induces cytotoxicity in hepatocellular cancer cells through oxidative DNA damage and ataxia telangiectasia-mutated nuclear protein kinase activation

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Integrity of the LXXLL motif in Stat6 is required for the inhibition of breast cancer cell growth and enhancement of differentiation in the context of progesterone

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Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases

Eun Jung Choi, Bong Jun Cho, David J Lee, Yeo Hyeon Hwang, Sun Ha Chun, Hans H Kim, In Ah Kim

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High-incidence of PTEN mutations in Chinese patients with primary small cell carcinoma of the esophagus

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BIMELis a key effector molecule in oxidative stress-mediated apoptosis in acute myeloid leukemia cells when combined with arsenic trioxide and buthionine sulfoximine

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Open Access Study protocol

The Nightingale study: rationale, study design and baseline characteristics of a prospective cohort study on shift work and breast cancer risk among nurses

Anouk Pijpe, Pauline Slottje, Cres van Pelt, Floor Stehmann, Hans Kromhout, Flora E van Leeuwen, Roel CH Vermeulen, Matti A Rookus

Open Access Research article

Prognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis

Wei-Kai Xiao, Chao-Ying Qi, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng, Li-Jian Liang

Open Access Research article

Ratio of n-3/n-6 PUFAs and risk of breast cancer: a meta-analysis of 274135 adult females from 11 independent prospective studies

Bo Yang, Xiao-Li Ren, Yuan-Qin Fu, Jin-Long Gao, Duo Li

Open Access Research article

Identification of the collagen type 1 alpha 1 gene (COL1A1) as a candidate survival-related factor associated with hepatocellular carcinoma

Masamichi Hayashi, Shuji Nomoto, Mitsuhiro Hishida, Yoshikuni Inokawa, Mitsuro Kanda, Yukiyasu Okamura, Yoko Nishikawa, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Shin Takeda, Yasuhiro Kodera

Open Access Research article

Prognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis

Wei-Kai Xiao, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng, Li-Jian Liang

Open Access Research article

Impact of chromosomal instability on colorectal cancer progression and outcome

Béatrice Orsetti, Janick Selves, Caroline Bascoul-Mollevi, Laurence Lasorsa, Karine Gordien, Frédéric Bibeau, Blandine Massemin, François Paraf, Isabelle Soubeyran, Isabelle Hostein, Valérie Dapremont, Rosine Guimbaud, Christophe Cazaux, Michel Longy, Charles Theillet

Open Access Research article

Stage and tissue-specific prognostic impact of miR-182 in NSCLC

Helge Stenvold, Tom Donnem, Sigve Andersen, Samer Al-Saad, Lill-Tove Busund, Roy M Bremnes

Open Access Research article

The role of CXC-chemokine receptor CXCR2 and suppressor of cytokine signaling-3 (SOCS-3) in renal cell carcinoma

Anastasios Stofas, Georgia Levidou, Christina Piperi, Christos Adamopoulos, Georgia Dalagiorgou, Aristotelis Bamias, Alexandra Karadimou, George A Lainakis, Stefanos Papadoukakis, Konstantinos Stravodimos, Meletios-Athanasios Dimopoulos, Efstratios Patsouris, Hariklia Gakiopoulou, Penelope Korkolopoulou

Open Access Research article

Ki-67 is a valuable prognostic predictor of lymphoma but its utility varies in lymphoma subtypes: evidence from a systematic meta-analysis

Xin He, Zhigang Chen, Tao Fu, Xueli Jin, Teng Yu, Yun Liang, Xiaoying Zhao, Liansheng Huang

Open Access Research article

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

Tal Leibovich-Rivkin, Yulia Liubomirski, Tsipi Meshel, Anastasia Abashidze, Daphna Brisker, Hilla Solomon, Varda Rotter, Miguel Weil, Adit Ben-Baruch

Open Access Research article

Interaction of translationally controlled tumor protein with Apaf-1 is involved in the development of chemoresistance in HeLa cells

Jaehoon Jung, Hyo Young Kim, Jeehye Maeng, Moonhee Kim, Dong Hae Shin, Kyunglim Lee

Open Access Research article

Sunitinib in combination with trastuzumab for the treatment of advanced breast cancer: activity and safety results from a phase II study

Thomas Bachelot, Jose A Garcia-Saenz, Sunil Verma, Maya Gutierrez, Xavier Pivot, Mark F Kozloff, Catherine Prady, Xin Huang, Reza Khosravan, Zhixiao Wang, Rossano Cesari, Vanessa Tassell, Kenneth A Kern, Jean-Yves Blay, Ana Lluch

Open Access Research article

Adjuvant therapy after resection of colorectal liver metastases: the predictive value of the MSKCC clinical risk score in the era of modern chemotherapy

Nuh N Rahbari, Christoph Reissfelder, Henning Schulze-Bergkamen, Dirk Jäger, Markus W Büchler, Jürgen Weitz, Moritz Koch

Open Access Research article

Early diagnostic value of survivin and its alternative splice variants in breast cancer

Salma Khan, Heather Ferguson Bennit, David Turay, Mia Perez, Saied Mirshahidi, Yuan Yuan, Nathan R Wall

Open Access Research article

Vasculature analysis of patient derived tumor xenografts using species-specific PCR assays: evidence of tumor endothelial cells and atypical VEGFA-VEGFR1/2 signalings

Ivan Bieche, Sophie Vacher, David Vallerand, Sophie Richon, Rana Hatem, Ludmilla De Plater, Ahmed Dahmani, Fariba Némati, Eric Angevin, Elisabetta Marangoni, Sergio Roman-Roman, Didier Decaudin, Virginie Dangles-Marie

Open Access Research article

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

Aki Miyasaka, Katsutoshi Oda, Yuji Ikeda, Osamu Wada-Hiraike, Tomoko Kashiyama, Atsushi Enomoto, Noriko Hosoya, Takahiro Koso, Tomohiko Fukuda, Kanako Inaba, Kenbun Sone, Yuriko Uehara, Reiko Kurikawa, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto, Shunsuke Nakagawa, Hiroyuki Kuramoto, Kiyoshi Miyagawa, Tetsu Yano, Kei Kawana, Yutaka Osuga, Tomoyuki Fujii

Open Access Research article

T cells but not NK cells are associated with a favourable outcome for resected colorectal liver metastases

Siân A Pugh, Rebecca J Harrison, John N Primrose, Salim I Khakoo

Open Access Research article

SMAD4 Loss triggers the phenotypic changes of pancreatic ductal adenocarcinoma cells

Yu-Wen Chen, Pi-Jung Hsiao, Ching-Chieh Weng, Kung-Kai Kuo, Tzu-Lei Kuo, Deng-Chyang Wu, Wen-Chun Hung, Kuang-Hung Cheng

Open Access Research article

Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation

Sérgia Velho, Ana Pinto, Danilo Licastro, Maria José Oliveira, Filipa Sousa, Elia Stupka, Raquel Seruca

Open Access Study protocol

GASTRICHIP: D2 resection and hyperthermic intraperitoneal chemotherapy in locally advanced gastric carcinoma: a randomized and multicenter phase III study

Olivier Glehen, Guillaume Passot, Laurent Villeneuve, Delphine Vaudoyer, Sylvie Bin-Dorel, Gilles Boschetti, Eric Piaton, Alfredo Garofalo

Open Access Research article

Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer

Rajani Kanteti, Essam El-Hashani, Immanuel Dhanasingh, Maria Tretiakova, Aliya N Husain, Sherven Sharma, Jay Sharma, Everett E Vokes, Ravi Salgia

Open Access Debate

Imagine a world without cancer

Björn LDM Brücher, Gary Lyman, Richard van Hillegersberg, Raphael E Pollock, Florian Lordick, Han-Kwang Yang, Toshikazu Ushijima, Khay-Guan Yeoh, Tomas Skricka, Wojciech Polkowski, Grzegorz Wallner, Vic Verwaal, Alfredo Garofalo, Domenico D’Ugo, Franco Roviello, Hans-Ulrich Steinau, Timothy J Wallace, Martin Daumer, Nitah Maihle, Thomas J Reid III, Michel Ducreux, Yuko Kitagawa, Alexander Knuth, Bruno Zilberstein, Scott R Steele, Ijaz S Jamall

Open Access Research article

Alcohol consumption, cigarette smoking and the risk of subtypes of head-neck cancer: results from the Netherlands Cohort Study

Denise HE Maasland, Piet A van den Brandt, Bernd Kremer, R Alexandra (Sandra) Goldbohm, Leo J Schouten

Open Access Research article

Glucocorticoid receptor repression mediated by BRCA1 inactivation in ovarian cancer

Yuan-Yuan Fang, Da Li, Chen Cao, Chun-Yan Li, Ting-Ting Li

Open Access Research article

Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study

Lusik Cherkezyan, Yolanda Stypula-Cyrus, Hariharan Subramanian, Craig White, Mart Dela Cruz, Ramesh K Wali, Michael J Goldberg, Laura K Bianchi, Hemant K Roy, Vadim Backman

Open Access Research article

Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer

Marcelo Sobral Leite, Letícia Carlos Giacomin, Diogo Nascimento Piranda, Juliana Simões Festa-Vasconcellos, Vanessa Indio-do-Brasil, Sérgio Koifman, Rodrigo Soares de Moura-Neto, Marcelo Alex de Carvalho, Rosane Vianna-Jorge

Open Access Research article

Prognostic implications of ezrin and phosphorylated ezrin expression in non-small cell lung cancer

Tiefeng Jin, Jingchun Jin, Xiangyu Li, Songnan Zhang, Yun Ho Choi, Yingshi Piao, Xionghu Shen, Zhenhua Lin

Open Access Research article

Norcantharidin inhibits tumor growth and vasculogenic mimicry of human gallbladder carcinomas by suppression of the PI3-K/MMPs/Ln-5γ2 signaling pathway

Jing-Tao Zhang, Wei Sun, Wen-Zhong Zhang, Chun-Yan Ge, Zhong-Yan Liu, Ze-Ming Zhao, Xing-Sui Lu, Yue-Zu Fan

Open Access Research article

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness

Mohammad-Saeid Jami, Jinxuan Hou, Miao Liu, Michelle L Varney, Hesham Hassan, Jixin Dong, Liying Geng, Jing Wang, Fang Yu, Xin Huang, Hong Peng, Kai Fu, Yan Li, Rakesh K Singh, Shi-Jian Ding

Open Access Research article

Novel transcripts from a distinct promoter that encode the full-length AKT1 in human breast cancer cells

Jeffrey W Schmidt, Barbara L Wehde, Kazuhito Sakamoto, Aleata A Triplett, William W West, Kay-Uwe Wagner

Open Access Research article

Expression of methionine adenosyltransferase 2A in renal cell carcinomas and potential mechanism for kidney carcinogenesis

Xuliang Wang, Xiaoqiang Guo, Wenshui Yu, Cailing Li, Yaoting Gui, Zhiming Cai

Open Access Research article

Tea consumption and the risk of five major cancers: a dose–response meta-analysis of prospective studies

Feifei Yu, Zhichao Jin, Hong Jiang, Chun Xiang, Jianyuan Tang, Tuo Li, Jia He

Open Access Research article

Nucleostemin expression in invasive breast cancer

Takayuki Kobayashi, Kenkichi Masutomi, Kenji Tamura, Tomoyuki Moriya, Tamio Yamasaki, Yasuhiro Fujiwara, Shunji Takahashi, Junji Yamamoto, Hitoshi Tsuda

Open Access Research article

GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis

De-cai Yu, Jia Liu, Jun Chen, Jiao-jiao Shao, Xiao Shen, Hong-guang Xia, Chao-jun Li, Bin Xue, Yi-tao Ding

Open Access Research article

Genetic inhibition of the atypical kinase Wee1 selectively drives apoptosis of p53 inactive tumor cells

William N Pappano, Qian Zhang, Lora A Tucker, Chris Tse, Jieyi Wang

Open Access Research article

Survival disparities in Australia: an analysis of patterns of care and comorbidities among indigenous and non-indigenous cancer patients

Suzanne P Moore, Adèle C Green, Freddie Bray, Gail Garvey, Michael Coory, Jennifer Martin, Patricia C Valery

Open Access Research article

Overexpression of SIRT1 promotes metastasis through epithelial-mesenchymal transition in hepatocellular carcinoma

Chong Hao, Peng-Xi Zhu, Xue Yang, Zhi-Peng Han, Jing-Hua Jiang, Chen Zong, Xu-Guang Zhang, Wen-Ting Liu, Qiu-Dong Zhao, Ting-Ting Fan, Li Zhang, Li-Xin Wei

Open Access Research article

Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia

Sarah M Judge, Chia-Ling Wu, Adam W Beharry, Brandon M Roberts, Leonardo F Ferreira, Susan C Kandarian, Andrew R Judge

Open Access Erratum

Erratum to: Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma

Romilda Cardin, Marika Piciocchi, Alessandro Sinigaglia, Enrico Lavezzo, Marina Bortolami, Andromachi Kotsafti, Umberto Cillo, Giacomo Zanus, Claudia Mescoli, Massimo Rugge, Fabio Farinati

Open Access Erratum

Erratum to: BiOsimilaRs in the management of anaemia secondary to chemotherapy in HaEmatology and Oncology: results of the ORHEO observational study

Mauricette Michallet, Elisabeth Luporsi, Pierre Soubeyran, Nadia Ali Amar, Vincent Boulanger, Miguel Carreiro, Louis-Marie Dourthe, Jean-Luc Labourey, Daniel Lepille, Frédéric Maloisel, Jean-Loup Mouysset, Sophie Nahon, Bérengère Narciso, Pierre Nouyrigat, Raouf Radji, Nacéra Sakek, Hélène Albrand

Open Access Erratum

Erratum to: Systematic review and meta-analysis of tumor biomarkers in predicting prognosis in esophageal cancer

Meilan Chen, Jizheng Huang, Zhenli Zhu, Jun Zhang, Ke Li

Open Access Research article

Platelet extracts induce growth, migration and invasion in human hepatocellular carcinoma in vitro

Brian I Carr, Aldo Cavallini, Rosalba D’Alessandro, Maria Grazia Refolo, Catia Lippolis, Antonio Mazzocca, Caterina Messa

Open Access Research article

Preoperative chemoradiotherapy in rectal cancer induces changes in the expression of nuclear β-catenin: prognostic significance

Jaime Gomez-Millan, Lydia Perez, Ines Aroca, Maria del Mar Delgado, Vanessa De Luque, Alicia Román, Esperanza Torres, Soraya Ramos, Sofia Perez, Eloisa Bayo, Jose Antonio Medina

Open Access Research article

Obesity is a significant risk factor for breast cancer in Arab women

Naser Elkum, Taher Al-Tweigeri, Dahish Ajarim, Ali Al-Zahrani, Suad M Bin Amer, Abdelilah Aboussekhra

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