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Zeitschrift

BMC Cancer

BMC Cancer 1/2014

Ausgabe 1/2014

Inhaltsverzeichnis ( 997 Artikel )

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition

Gaofeng Xiong, Lei Deng, Jieqing Zhu, Piotr G Rychahou, Ren Xu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Neoadjuvant chemotherapy in breast cancer significantly reduces number of yielded lymph nodes by axillary dissection

Thalia Erbes, Marzenna Orlowska-Volk, Axel zur Hausen, Gerta Rücker, Sebastian Mayer, Matthias Voigt, Juliane Farthmann, Severine Iborra, Marc Hirschfeld, Philipp T Meyer, Gerald Gitsch, Elmar Stickeler

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

Raghibul Hasan, Rinu Sharma, Anoop Saraya, Tushar K Chattopadhyay, Siddartha DattaGupta, Paul G Walfish, Shyam S Chauhan, Ranju Ralhan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Lymph node fine needle Cytology in the staging and follow-up of Cutaneous Lymphomas

Elena Vigliar, Immacolata Cozzolino, Marco Picardi, Anna Lucia Peluso, Laura Virginia Sosa Fernandez, Antonio Vetrani, Gerardo Botti, Fabrizio Pane, Carmine Selleri, Pio Zeppa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High-resolution 3D micro-CT imaging of breast microcalcifications: a preliminary analysis

Inneke Willekens, Elke Van de Casteele, Nico Buls, Frederik Temmermans, Bart Jansen, Rudi Deklerck, Johan de Mey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Healthy lifestyle and risk of breast cancer for indigenous and non-indigenous women in New Zealand: a case control study

Fiona McKenzie, Lis Ellison-Loschmann, Mona Jeffreys, Ridvan Firestone, Neil Pearce, Isabelle Romieu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAFmutations

Michaela Angelika Ihle, Jana Fassunke, Katharina König, Inga Grünewald, Max Schlaak, Nicole Kreuzberg, Lothar Tietze, Hans-Ulrich Schildhaus, Reinhard Büttner, Sabine Merkelbach-Bruse

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Study protocol of a randomized controlled trial comparing Mindfulness-Based Stress Reduction with treatment as usual in reducing psychological distress in patients with lung cancer and their partners: the MILON study

Melanie PJ Schellekens, Desiree GM van den Hurk, Judith B Prins, Johan Molema, A Rogier T Donders, Willem H Woertman, Miep A van der Drift, Anne EM Speckens

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluation of a novel rash scale and a serum proteomic predictor in a randomized phase II trial of sequential or concurrent cetuximab and pemetrexed in previously treated non-small cell lung cancer

Michael L Maitland, Matthew R Levine, Mario E Lacouture, Kristen E Wroblewski, Christine H Chung, Ilyssa O Gordon, Livia Szeto, Gail Ratko, Keyoumars Soltani, Mark F Kozloff, Philip C Hoffman, Ravi Salgia, David P Carbone, Theodore G Karrison, Everett E Vokes

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Significance of CD44 expression in head and neck cancer: a systemic review and meta-analysis

Jianqiang Chen, Jianding Zhou, Jie Lu, Hua Xiong, Xueli Shi, Liang Gong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Helical intensity-modulated Radiotherapy of the Pelvic Lymph Nodes with Integrated Boost to the Prostate Bed - Initial Results of the PLATIN 3 Trial

Sonja Katayama, Gregor Habl, Kerstin Kessel, Lutz Edler, Juergen Debus, Klaus Herfarth, Florian Sterzing

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Cytoreductive surgery followed by chemotherapy versus chemotherapy alone for recurrent platinum-sensitive epithelial ovarian cancer (SOCceR trial): a multicenter randomised controlled study

Rafli van de Laar, Petra LM Zusterzeel, Toon Van Gorp, Marrije R Buist, Willemien J van Driel, Katja N Gaarenstroom, Henriette JG Arts, Johannes CM van Huisseling, Ralph HM Hermans, Johanna MA Pijnenborg, Eltjo MJ Schutter, Harold MP Pelikan, Jos HA Vollebergh, Mirjam JA Engelen, Joanna IntHout, Roy FPM Kruitwagen, Leon FAG Massuger

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer

Rajesh Thangapazham, Francisco Saenz, Shilpa Katta, Ahmed A Mohamed, Shyh-Han Tan, Gyorgy Petrovics, Shiv Srivastava, Albert Dobi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke

Matthew North, Joe Shuga, Michele Fromowitz, Alexandre Loguinov, Kevin Shannon, Luoping Zhang, Martyn T Smith, Chris D Vulpe

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Overexpression of phosphatidylinositol 4-kinase type IIIα is associated with undifferentiated status and poor prognosis of human hepatocellular carcinoma

Adeodat Ilboudo, Jean-Charles Nault, Hélène Dubois-Pot-Schneider, Anne Corlu, Jessica Zucman-Rossi, Michel Samson, Jacques Le Seyec

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression

Amy V Paschall, Mary A Zimmerman, Christina M Torres, Dafeng Yang, May R Chen, Xia Li, Erhard Bieberich, Aiping Bai, Jacek Bielawski, Alicja Bielawska, Kebin Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Combination of expression levels of miR-21 and miR-126 is associated with cancer-specific survival in clear-cell renal cell carcinoma

Daniel Vergho, Susanne Kneitz, Andreas Rosenwald, Charlotte Scherer, Martin Spahn, Maximilian Burger, Hubertus Riedmiller, Burkhard Kneitz

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Plasma 25-hydroxyvitamin D3 is associated with decreased risk of postmenopausal breast cancer in whites: a nested case–control study in the multiethnic cohort study

Yeonju Kim, Adrian A Franke, Yurii B Shvetsov, Lynne R Wilkens, Robert V Cooney, Galina Lurie, Gertraud Maskarinec, Brenda Y Hernandez, Loïc Le Marchand, Brian E Henderson, Laurence N Kolonel, Marc T Goodman

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

The efficacy of a standardized questionnaire in facilitating personalized communication about problems encountered in cancer genetic counseling: design of a randomized controlled trial

Willem Eijzenga, Neil K Aaronson, Irma Kluijt, Grace N Sidharta, Daniela EE Hahn, Margreet GEM Ausems, Eveline MA Bleiker

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

RETRACTED ARTICLE: STMN-1 is a potential marker of lymph node metastasis in distal esophageal adenocarcinomas and silencing its expression can reverse malignant phenotype of tumor cells

Javed Akhtar, Zhou Wang, Che Yu, Chen-Sheng Li, Yu-Long Shi, Hong-Jun Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma

Jiayin Xie, Liang Zhang, Mengxia Li, Jia Du, Liwei Zhou, Senlin Yang, Linli Zeng, Zengpeng Li, Ge Wang, Dong Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Risks of postoperative paresis in motor eloquently and non-eloquently located brain metastases

Thomas Obermueller, Michael Schaeffner, Julia Gerhardt, Bernhard Meyer, Florian Ringel, Sandro M Krieg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice

Victoria Hillerdal, Mohanraj Ramachandran, Justyna Leja, Magnus Essand

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Progression-free survival at 2 years is a reliable surrogate marker for the 5-year survival rate in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy

Hiroaki Akamatsu, Keita Mori, Tateaki Naito, Hisao Imai, Akira Ono, Takehito Shukuya, Tetsuhiko Taira, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi, Nobuyuki Yamamoto

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The novel IGF-IR/Akt–dependent anticancer activities of glucosamine

Ki-Hoon Song, Ju-Hee Kang, Jong-Kyu Woo, Jeong-Seok Nam, Hye-Young Min, Ho-Young Lee, Soo-Youl Kim, Seung-Hyun Oh

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

PMA synergistically enhances apicularen A-induced cytotoxicity by disrupting microtubule networks in HeLa cells

Kang-Sik Seo, Jong-Seok Kim, Ji-Hoon Park, Kyoung-Sub Song, Eun-Jin Yun, Jong-Il Park, Gi Ryang Kweon, Wan-Hee Yoon, Kyu Lim, Byung-Doo Hwang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cells

Harris Wang, The Vo, Ali Hajar, Sarah Li, Xinmei Chen, Amadeo M Parissenti, David N Brindley, Zhixiang Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells

Jian Kang, C Marcelo Sergio, Robert L Sutherland, Elizabeth A Musgrove

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Novel treatment option for MUC16-positive malignancies with the targeted TRAIL-based fusion protein Meso-TR3

Gunjal Garg, Jesse Gibbs, Brian Belt, Matthew A Powell, David G Mutch, Peter Goedegebuure, Lynne Collins, David Piwnica-Worms, William G Hawkins, Dirk Spitzer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Is [F-18]-fluorodeoxy-D-glucose positron emission tomography of value in the management of patients with craniofacial bone sarcomas undergoing neo-adjuvant treatment?

Anna Maria Frezza, Tim Beale, Jamshed Bomanji, Amrita Jay, Nicholas Kalavrezos, Palma Dileo, Jeremy Whelan, Sandra J Strauss

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Influence of pain severity on the quality of life in patients with head and neck cancer before antineoplastic therapy

Karine G Oliveira, Sandra V von Zeidler, Jose RV Podestá, Agenor Sena, Evandro D Souza, Jeferson Lenzi, Nazaré S Bissoli, Sonia A Gouvea

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model – role of tumor stroma cells

Katharina Leithner, Christoph Wohlkoenig, Elvira Stacher, Jörg Lindenmann, Nicole A Hofmann, Birgit Gallé, Christian Guelly, Franz Quehenberger, Philipp Stiegler, Freyja-Maria Smolle-Jüttner, Sjaak Philipsen, Helmut H Popper, Andelko Hrzenjak, Andrea Olschewski, Horst Olschewski

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High prevalence of Y-box protein-1/p18 fragment in plasma of patients with malignancies of different origin

Frank Tacke, Oliver Galm, Nicolas Kanig, Eray Yagmur, Sabine Brandt, Jonathan A Lindquist, Christiane S Eberhardt, Ute Raffetseder, Peter R Mertens

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A comprehensive look at transcription factor gene expression changes in colorectal adenomas

Janine Vonlanthen, Michal J Okoniewski, Mirco Menigatti, Elisa Cattaneo, Daniela Pellegrini-Ochsner, Ritva Haider, Josef Jiricny, Teresa Staiano, Federico Buffoli, Giancarlo Marra

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inverse association of colorectal cancer prevalence to serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in a large Appalachian population

Kim E Innes, Jeffrey H Wimsatt, Stephanie Frisbee, Alan M Ducatman

01.12.2014 | Reviewer acknowledgement | Ausgabe 1/2014 Open Access

Reviewer acknowledgement 2013

Dafne Solera

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials

Raymond Javan Chan, Joan Webster, Bryan Chung, Louise Marquart, Muhtashimuddin Ahmed, Stuart Garantziotis

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of CXCR4 and breast cancer prognosis: a systematic review and meta-analysis

Zhigang Zhang, Chao Ni, Wuzhen Chen, Ping Wu, Zhen Wang, Junhua Yin, Jian Huang, Fuming Qiu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Decreased expression of key tumour suppressor microRNAs is associated with lymph node metastases in triple negative breast cancer

Kelly A Avery-Kiejda, Stephen G Braye, Andrea Mathe, John F Forbes, Rodney J Scott

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

Xuejuan Jiang, Chiu-Chen Tseng, Leslie Bernstein, Anna H Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Are we missing the Institute of Medicine’s mark? A systematic review of patient-reported outcome measures assessing quality of patient-centred cancer care

Flora Tzelepis, Shiho K Rose, Robert W Sanson-Fisher, Tara Clinton-McHarg, Mariko L Carey, Christine L Paul

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Outcome disparities in African American women with triple negative breast cancer: a comparison of epidemiological and molecular factors between African American and Caucasian women with triple negative breast cancer

Lori A Sturtz, Jen Melley, Kim Mamula, Craig D Shriver, Rachel E Ellsworth

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Peritumoral ductular reaction: a poor postoperative prognostic factor for hepatocellular carcinoma

Minhui Xu, Feng Xie, Guangyang Qian, Yingying Jing, Shanshan Zhang, Lu Gao, Tao Zheng, Mengchao Wu, Jiamei Yang, Lixin Wei

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Downregulation of Smurf2, a tumor-suppressive ubiquitin ligase, in triple-negative breast cancers: Involvement of the RB-microRNA axis

Xianpeng Liu, Xin Gu, Limin Sun, Ashley B Flowers, Alfred W Rademaker, Yiran Zhou, Hiroaki Kiyokawa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Radical hysterectomy with adjuvant radiotherapy versus radical radiotherapy for FIGO stage IIB cervical cancer

Yanlan Chai, Tao Wang, Juan Wang, Yunyi Yang, Ying Gao, Jiyong Gao, Shangfeng Gao, Yueling Wang, Xi Zhou, Zi Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Microvascular invasion (MVI) is a poorer prognostic predictor for small hepatocellular carcinoma

Min Du, Lingli Chen, Jing Zhao, Feng Tian, Haiying Zeng, Yunshan Tan, Huichuan Sun, Jian Zhou, Yuan Ji

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A longitudinal analysis of patient satisfaction with care and quality of life in ambulatory oncology based on the OUT-PATSAT35 questionnaire

Thanh Vân France Nguyen, Amélie Anota, Anne Brédart, Alain Monnier, Jean-François Bosset, Mariette Mercier

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects

Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei, Hongxin Deng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Acute toxicity of definitive chemoradiation in patients with inoperable or irresectable esophageal carcinoma

Nadia Haj Mohammad, Maarten CCM Hulshof, Jacques JGHM Bergman, Debby Geijsen, Johanna W Wilmink, Mark I van Berge Henegouwen, Hanneke WM van Laarhoven

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A retrospective comparative exploratory study on two Methylentetrahydrofolate Reductase (MTHFR) polymorphisms in esophagogastric cancer: the A1298C MTHFR polymorphism is an independent prognostic factor only in neoadjuvantly treated gastric cancer patients

Susanne Blank, Sivaramakrishna Rachakonda, Gisela Keller, Wilko Weichert, Florian Lordick, Rupert Langer, Christoph Springfeld, Thomas Bruckner, Karen Becker, Rajiv Kumar, Katja Ott

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

ESR1gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients

Joaquina Martínez-Galán, Blanca Torres-Torres, María Isabel Núñez, Jesús López-Peñalver, Rosario Del Moral, José Mariano Ruiz De Almodóvar, Salomón Menjón, Ángel Concha, Clara Chamorro, Sandra Ríos, Juan Ramón Delgado

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Bithionol inhibits ovarian cancer cell growth In Vitro- studies on mechanism(s) of action

Vijayalakshmi N Ayyagari, Laurent Brard

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma

Marion Fehlker, Matthew R Huska, Thomas Jöns, Miguel A Andrade-Navarro, Wolfgang Kemmner

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer

Laura Maria Pradella, Cecilia Evangelisti, Claudia Ligorio, Claudio Ceccarelli, Iria Neri, Roberta Zuntini, Laura Benedetta Amato, Simona Ferrari, Alberto Maria Martelli, Giuseppe Gasparre, Daniela Turchetti

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells

Christin Kretzschmar, Catrin Roolf, Tina-Susann Langhammer, Anett Sekora, Anahit Pews-Davtyan, Matthias Beller, Moritz J Frech, Christian Eisenlöffel, Arndt Rolfs, Christian Junghanss

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Adaptation of leukemia cells to hypoxic condition through switching the energy metabolism or avoiding the oxidative stress

Mineaki Goto, Hiroshi Miwa, Kazuto Suganuma, Norikazu Tsunekawa-Imai, Masato Shikami, Motonori Mizutani, Shohei Mizuno, Ichiro Hanamura, Masakazu Nitta

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs

Kati Erdmann, Knut Kaulke, Cathleen Thomae, Doreen Huebner, Mildred Sergon, Michael Froehner, Manfred P Wirth, Susanne Fuessel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A panel of genes methylated with high frequency in colorectal cancer

Susan M Mitchell, Jason P Ross, Horace R Drew, Thu Ho, Glenn S Brown, Neil FW Saunders, Konsta R Duesing, Michael J Buckley, Rob Dunne, Iain Beetson, Keith N Rand, Aidan McEvoy, Melissa L Thomas, Rohan T Baker, David A Wattchow, Graeme P Young, Trevor J Lockett, Susanne K Pedersen, Lawrence C LaPointe, Peter L Molloy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Examestane in advanced or recurrent endometrial carcinoma: a prospective phase II study by the Nordic Society of Gynecologic Oncology (NSGO)

Kristina Lindemann, Susanne Malander, Rene D Christensen, Mansoor R Mirza, Gunnar B Kristensen, Elisabeth Aavall-Lundqvist, Ignace Vergote, Per Rosenberg, Karin Boman, Britta Nordstrøm

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Microvascular density of regenerative nodule to small hepatocellular carcinoma by automated analysis using CD105 and CD34 immunoexpression

Juliana Passos Paschoal, Vagner Bernardo, Nathalie Henriques Silva Canedo, Osmar Damasceno Ribeiro, Adriana Caroli-Bottino, Vera Lucia Pannain

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer

Christopher A McGoldrick, Yu-Lin Jiang, Victor Paromov, Marianne Brannon, Koyamangalath Krishnan, William L Stone

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Feasibility of isometric spinal muscle training in patients with bone metastases under radiation therapy - first results of a randomized pilot trial

Harald Rief, Georg Omlor, Michael Akbar, Thomas Welzel, Thomas Bruckner, Stefan Rieken, Matthias F Haefner, Ingmar Schlampp, Alexandros Gioules, Daniel Habermehl, Friedbert von Nettelbladt, Jürgen Debus

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-200a inhibits epithelial-mesenchymal transition of pancreatic cancer stem cell

Yuhua Lu, Jingjing Lu, Xiaohong Li, Hui Zhu, Xiangjun Fan, Shajun Zhu, Yao Wang, Qingsong Guo, Lei Wang, Yan Huang, Mingyan Zhu, Zhiwei Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells

Yu Zhao, Jie Huang, Li Zhang, Ying Qu, Jianfang Li, Beiqin Yu, Min Yan, Yingyan Yu, Bingya Liu, Zhenggang Zhu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

FOXA1 promotes tumor cell proliferation through AR involving the Notch pathway in endometrial cancer

Meiting Qiu, Wei Bao, Jingyun Wang, Tingting Yang, Xiaoying He, Yun Liao, Xiaoping Wan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A new technique combining virtual simulation and methylene blue staining for the localization of small peripheral pulmonary lesions

Yang Shentu, Liang Zhang, Hengle Gu, Feng Mao, Minghui Cai, Zhengping Ding, Zhiqiang Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

Susann Voigt, Stephan Philipp, Parvin Davarnia, Supandi Winoto-Morbach, Christian Röder, Christoph Arenz, Anna Trauzold, Dieter Kabelitz, Stefan Schütze, Holger Kalthoff, Dieter Adam

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Redox-responsive targeted gelatin nanoparticles for delivery of combination wt-p53 expressing plasmid DNA and gemcitabine in the treatment of pancreatic cancer

Jing Xu, Amit Singh, Mansoor M Amiji

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker

Bente Vilming Elgaaen, Ole Kristoffer Olstad, Kari Bente Foss Haug, Berit Brusletto, Leiv Sandvik, Anne Cathrine Staff, Kaare M Gautvik, Ben Davidson

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

My Road Ahead study protocol: a randomised controlled trial of an online psychological intervention for men following treatment for localised prostate cancer

Addie C Wootten, Jo-Anne M Abbott, Katherine E Chisholm, David W Austin, Britt Klein, Marita P McCabe, Denny Meyer, Anthony J Costello, Declan G Murphy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Protein kinase C-delta inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo

Zhihong Chen, Lora W Forman, Robert M Williams, Douglas V Faller

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The effect of patient characteristics on second primary cancer risk in France

Jérémie Jégu, Marc Colonna, Laetitia Daubisse-Marliac, Brigitte Trétarre, Olivier Ganry, Anne-Valérie Guizard, Simona Bara, Xavier Troussard, Véronique Bouvier, Anne-Sophie Woronoff, Michel Velten

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Approaches for classifying the indications for colonoscopy using detailed clinical data

Hirut Fassil, Kenneth F Adams, Sheila Weinmann, V Paul Doria-Rose, Eric Johnson, Andrew E Williams, Douglas A Corley, Chyke A Doubeni

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics

Jiří Mayer, Christopher Arthur, Jacques Delaunay, Grzegorz Mazur, Xavier G Thomas, Agnieszka Wierzbowska, Farhad Ravandi, Erhan Berrak, Mark Jones, Yuhan Li, Hagop M Kantarjian

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells

Ummuhan Demir, Andrea Koehler, Rainer Schneider, Susann Schweiger, Helmut Klocker

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical implications in the shift of syndecan-1 expression from the cell membrane to the cytoplasm in bladder cancer

Makito Miyake, Adrienne Lawton, Yunfeng Dai, Myron Chang, Lourdes Mengual, Antonio Alcaraz, Steve Goodison, Charles J Rosser

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Socioeconomic environment and cancer incidence: a French population-based study in Normandy

Josephine Bryere, Olivier Dejardin, Veronique Bouvier, Marc Colonna, Anne-Valérie Guizard, Xavier Troussard, Carole Pornet, Françoise Galateau-Salle, Simona Bara, Ludivine Launay, Lydia Guittet, Guy Launoy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

DW-MRI in assessment of the hypoxic fraction, interstitial fluid pressure, and metastatic propensity of melanoma xenografts

Tord Hompland, Christine Ellingsen, Kanthi Galappathi, Einar K Rofstad

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Up-regulated MicroRNA-181a induces carcinogenesis in Hepatitis B virus-related hepatocellular carcinoma by targeting E2F5

Chengcheng Zou, Yongguo Li, Yiyi Cao, Jinnan Zhang, Jingrong Jiang, Yanrui Sheng, Sen Wang, Ailong Huang, Hua Tang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Regulation of Mcl-1 by constitutive activation of NF-kappaB contributes to cell viability in human esophageal squamous cell carcinoma cells

Haidan Liu, Jinfu Yang, Yunchang Yuan, Zhenkun Xia, Mingjiu Chen, Li Xie, Xiaolong Ma, Jian Wang, Sufeng Ouyang, Qin Wu, Fenglei Yu, Xinmin Zhou, Yifeng Yang, Ya Cao, Jianguo Hu, Bangliang Yin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580 000 subjects within the Me-Can project

Björn Lindkvist, Dorthe Johansen, Tanja Stocks, Hans Concin, Tone Bjørge, Martin Almquist, Christel Häggström, Anders Engeland, Göran Hallmans, Gabriele Nagel, Håkan Jonsson, Randi Selmer, Hanno Ulmer, Steinar Tretli, Pär Stattin, Jonas Manjer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A genomics approach to identify susceptibilities of breast cancer cells to “fever-range” hyperthermia

Clarissa Amaya, Vittal Kurisetty, Jessica Stiles, Alice M Nyakeriga, Arunkumar Arumugam, Rajkumar Lakshmanaswamy, Cristian E Botez, Dianne C Mitchell, Brad A Bryan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The effect of ROCK-1 activity change on the adhesive and invasive ability of Y79 retinoblastoma cells

Jing Wang, Xiao-Hong Liu, Zi-Jian Yang, Bing Xie, Yi-Sheng Zhong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Enhanced detection of metastatic prostate cancer cells in human plasma with lipid bodies staining

Ranjana Mitra, Oscar B Goodman, Thuc T Le

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Decreased GATA5 mRNA expression associates with CpG island methylation and shortened recurrence-free survival in clear cell renal cell carcinoma

Inga Peters, Natalia Dubrowinskaja, Michael Kogosov, Mahmoud Abbas, Jörg Hennenlotter, Christoph von Klot, Axel S Merseburger, Arnulf Stenzl, Ralph Scherer, Markus A Kuczyk, Jürgen Serth

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management

Luca Faloppi, Mario Scartozzi, Maristella Bianconi, Gianluca Svegliati Baroni, Pierluigi Toniutto, Riccardo Giampieri, Michela Del Prete, Samuele De Minicis, Davide Bitetto, Cristian Loretelli, Marco D’Anzeo, Antonio Benedetti, Stefano Cascinu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cellular responses of BRCA1-defective and triple-negative breast cancer cells and in vitro BRCA1 interactions induced by metallo-intercalator ruthenium(II) complexes containing chloro-substituted phenylazopyridine

Tidarat Nhukeaw, Pornvichai Temboot, Kanidtha Hansongnern, Adisorn Ratanaphan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Overexpression of miR-9 in mast cells is associated with invasive behavior and spontaneous metastasis

Joelle M Fenger, Misty D Bear, Stefano Volinia, Tzu-Yin Lin, Bonnie K Harrington, Cheryl A London, William C Kisseberth

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells – a preclinical MR study in mice

Claudia Weidensteiner, Peter R Allegrini, Melanie Sticker-Jantscheff, Vincent Romanet, Stephane Ferretti, Paul MJ McSheehy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The epidemiology of gastrointestinal stromal tumors in Taiwan, 1998–2008: a nation-wide cancer registry-based study

Nai-Jung Chiang, Li-Tzong Chen, Chia-Rung Tsai, Jeffrey S Chang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG)

George Pentheroudakis, Vassiliki Kotoula, Elena Fountzilas, George Kouvatseas, George Basdanis, Ioannis Xanthakis, Thomas Makatsoris, Elpida Charalambous, Demetris Papamichael, Epaminontas Samantas, Pavlos Papakostas, Dimitrios Bafaloukos, Evangelia Razis, Christos Christodoulou, Ioannis Varthalitis, Nicholas Pavlidis, George Fountzilas

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Strategies and opportunities to STOP colon cancer in priority populations: pragmatic pilot study design and outcomes

Gloria D Coronado, William M Vollmer, Amanda Petrik, Josue Aguirre, Tanya Kapka, Jennifer DeVoe, Jon Puro, Tran Miers, Jennifer Lembach, Ann Turner, Jennifer Sanchez, Sally Retecki, Christine Nelson, Beverly Green

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

FemZone trial: a randomized phase II trial comparing neoadjuvant letrozole and zoledronic acid with letrozole in primary breast cancer patients

Peter A Fasching, Sebastian M Jud, Maik Hauschild, Sherko Kümmel, Martin Schütte, Matthias Warm, Volker Hanf, Dieter Grab, Jutta Krocker, Elmar Stickeler, Rolf Kreienberg, Thomas Müller, Thorsten Kühn, Christopher Wolf, Steffen Kahlert, Stefan Paepke, Michael Berghorn, Mathias Muth, Monika Baier, Birgit Wackwitz, Rüdiger Schulz-Wendtland, Matthias W Beckmann, Michael P Lux

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

PKC α regulates netrin-1/UNC5B-mediated survival pathway in bladder cancer

Jiao Liu, Chui-ze Kong, Da-xin Gong, Zhe Zhang, Yu-yan Zhu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas

Ksenia A Arkhipova, Anastasia N Sheyderman, Konstantin K Laktionov, Valeria V Mochalnikova, Irina B Zborovskaya

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Epidemiological study of prostate cancer (EPICAP): a population-based case–control study in France

Florence Menegaux, Antoinette Anger, Hasina Randrianasolo, Claire Mulot, Pierre Laurent-Puig, François Iborra, Jean-Pierre Bringer, Benoit Leizour, Rodolphe Thuret, Pierre-Jean Lamy, Xavier Rébillard, Brigitte Trétarre, EPICAP Study Group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin

Chen-Chieh Yang, Shun-Fu Chang, Jian-Kang Chao, Yi-Liang Lai, Wei-En Chang, Wen-Hsiu Hsu, Wu-Hsien Kuo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Human papillomavirus prevalence and type-distribution in women with cervical lesions: a cross-sectional study in Sri Lanka

Kanishka Karunaratne, Himali Ihalagama, Saman Rohitha, Anco Molijn, Kusuma Gopala, Johannes E Schmidt, Jing Chen, Sanjoy Datta, Shailesh Mehta

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Wnt modulates MCL1 to control cell survival in triple negative breast cancer

Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann, Yun Yen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Molecular characterization of exosome-like vesicles from breast cancer cells

Stefan Kruger, Zakaria Y Abd Elmageed, David H Hawke, Philipp M Wörner, David A Jansen, Asim B Abdel-Mageed, Eckhard U Alt, Reza Izadpanah

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response

Sophie Lehn, Nicholas P Tobin, Andrew H Sims, Olle Stål, Karin Jirström, Håkan Axelson, Göran Landberg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Wnt3a expression is associated with MMP-9 expression in primary tumor and metastatic site in recurrent or stage IV colorectal cancer

Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang, Hee-Na Kim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A pilot study of FDG PET/CT detects a link between brown adipose tissue and breast cancer

Qi Cao, Jerome Hersl, Hongloan La, Mark Smith, Jason Jenkins, Olga Goloubeva, Vasken Dilsizian, Katherine Tkaczuk, Wengen Chen, Laundette Jones

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Superparamagnetic iron oxide nanoparticles mediated 131I-hVEGF siRNA inhibits hepatocellular carcinoma tumor growth in nude mice

Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao, Wei Xiong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Estrogen receptor α-coupled Bmi1 regulation pathway in breast cancer and its clinical implications

Huali Wang, Haijing Liu, Xin Li, Jing Zhao, Hong Zhang, Jingzhuo Mao, Yongxin Zou, Hong Zhang, Shuang Zhang, Wei Hou, Lin Hou, Michael A McNutt, Bo Zhang

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Colorectal cancer stage at diagnosis in migrants versus non-migrants (KoMigra): study protocol of a cross-sectional study in Germany

Anne Dahlhaus, Corina Guethlin, Arthur Schall, Maja Taubenroth, Reyn van Ewijk, Hajo Zeeb, Zeycan Albay, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Maria Blettner, Andrea Siebenhofer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Can we accurately report PTEN status in advanced colorectal cancer?

Christopher Hocking, Jennifer E Hardingham, Vy Broadbridge, Joe Wrin, Amanda R Townsend, Niall Tebbutt, John Cooper, Andrew Ruszkiewicz, Chee Lee, Timothy J Price

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Systematic analysis of 18F-FDG PET and metabolism, proliferation and hypoxia markers for classification of head and neck tumors

Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin, Johan Bussink

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study

Yulan Ren, Boer Shan, Daren Shi, Huaying Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Analysis of the impact of platinum-based combination chemotherapy in small cell cervical carcinoma: a multicenter retrospective study in Chinese patients

Long Huang, Ling-Min Liao, An-Wen Liu, Jian-Bing Wu, Xiao-Ling Cheng, Jia-Xin Lin, Min Zheng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

Ekta Agarwal, Anathbandhu Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain, Sanjib Chowdhury

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

Kimberly C Wiegand, Bryan T Hennessy, Samuel Leung, Yemin Wang, Zhenlin Ju, Mollianne McGahren, Steve E Kalloger, Sarah Finlayson, Katherine Stemke-Hale, Yiling Lu, Fan Zhang, Michael S Anglesio, Blake Gilks, Gordon B Mills, David G Huntsman, Mark S Carey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang, Basil Rigas

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Intracellular coexpression of CXC- and CC– chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation

Sandra Pinto, Alicia Martínez-Romero, José-Enrique O’Connor, Rosario Gil-Benso, Teresa San-Miguel, Liria Terrádez, Carlos Monteagudo, Robert C Callaghan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Plasma level of LDL-cholesterol at diagnosis is a predictor factor of breast tumor progression

Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias, JC Mendes de Almeida

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Primary tumor regression speed after radiotherapy and its prognostic significance in nasopharyngeal carcinoma: a retrospective study

Ning Zhang, Shao-Bo Liang, Yan-Ming Deng, Rui-Liang Lu, Hai-Yang Chen, Hai Zhao, Zhi-Qian Lv, Shao-Qiang Liang, Lin Yang, Dong-Sheng Liu, Yong Chen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas

Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli, Katia Scotlandi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Age and stage at diagnosis: a hospital series of 11 women with intellectual disability and breast carcinoma

Daniel Satgé, Eric-André Sauleau, William Jacot, Fernand Raffi, Bernard Azéma, Jean-Claude Bouyat, Nicolas El Hage Assaf

01.12.2014 | Technical advance | Ausgabe 1/2014 Open Access

Bronchoscopic intratumoral injection of tranexamic acid to prevent excessive bleeding during multiple forceps biopsies of lesions with a high risk of bleeding: a prospective case series

Adil Zamani

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

Mariana Emerenciano, Thayana Conceição Barbosa, Bruno Almeida Lopes, Caroline Barbieri Blunck, Alessandra Faro, Camilla Andrade, Claus Meyer, Rolf Marschalek, Maria S Pombo-de-Oliveira, The Brazilian Collaborative Study Group of Infant Acute Leukemia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures

Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira, Maria S Pombo-de-Oliveira, Brazilian Collaborative Study Group of Infant Acute Leukaemia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumor-stroma metabolic relationship based on lactate shuttle can sustain prostate cancer progression

Patrizia Sanità, Mattia Capulli, Anna Teti, Giuseppe Paradiso Galatioto, Carlo Vicentini, Paola Chiarugi, Mauro Bologna, Adriano Angelucci

01.12.2014 | Technical advance | Ausgabe 1/2014 Open Access

Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens

Torsten Nielsen, Brett Wallden, Carl Schaper, Sean Ferree, Shuzhen Liu, Dongxia Gao, Garrett Barry, Naeem Dowidar, Malini Maysuria, James Storhoff

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Oral cancer cells may rewire alternative metabolic pathways to survive from siRNA silencing of metabolic enzymes

Min Zhang, Yang D Chai, Jeffrey Brumbaugh, Xiaojun Liu, Ramin Rabii, Sizhe Feng, Kaori Misuno, Diana Messadi, Shen Hu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: A potential new therapeutic approach

Nancy Santos-Martínez, Lorenza Díaz, David Ordaz-Rosado, Janice García-Quiroz, David Barrera, Euclides Avila, Ali Halhali, Heriberto Medina-Franco, María J Ibarra-Sánchez, José Esparza-López, Javier Camacho, Fernando Larrea, Rocío García-Becerra

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Prospective study of high-risk, BRCA1/2-mutation negative women: the ‘negative study’

Joanne Kotsopoulos, Kelly Metcalfe, Jill Alston, Dina Nikitina, Ophira Ginsburg, Andrea Eisen, Rochelle Demsky, Mohammad Akbari, Kevin Zbuk, Steven A Narod

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway

Ting Li, Qunling Zhang, Jian Zhang, Gong Yang, Zhimin Shao, Jianmin Luo, Minhao Fan, Chen Ni, Zhenhua Wu, Xichun Hu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Endothelial cell-derived interleukin-6 regulates tumor growth

Kathleen G Neiva, Kristy A Warner, Marcia S Campos, Zhaocheng Zhang, Juliana Moren, Theodora E Danciu, Jacques E Nör

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis

Gang Wu, Haiyang Liu, Hui He, Yawei Wang, Xiaojun Lu, Yanqiu Yu, Shuguan Xia, Xiangyu Meng, Yongfeng Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-378 is an independent prognostic factor and inhibits cell growth and invasion in colorectal cancer

Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li, Tong Zhou

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells

Sahana Suresh Babu, Yanet Valdez, Andrea Xu, Alice M O’Byrne, Fernando Calvo, Victor Lei, Edward M Conway

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of FISH biomarkers to detect chromosome abnormalities associated with prostate adenocarcinoma in tumour and field effect environment

Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison, Katerina Pestova

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increased IR-A/IR-B ratio in non-small cell lung cancers associates with lower epithelial-mesenchymal transition signature and longer survival in squamous cell lung carcinoma

Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao, Jiaqi Huang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Epigenetic silencing of miR-375 induces trastuzumab resistance in HER2-positive breast cancer by targeting IGF1R

Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang, Lin-Tao Jia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pharmacological inhibition of EZH2 as a promising differentiation therapy in embryonal RMS

Roberta Ciarapica, Elena Carcarino, Laura Adesso, Maria De Salvo, Giorgia Bracaglia, Pier Paolo Leoncini, Alessandra Dall’Agnese, Federica Verginelli, Giuseppe M Milano, Renata Boldrini, Alessandro Inserra, Stefano Stifani, Isabella Screpanti, Victor E Marquez, Sergio Valente, Antonello Mai, Pier Lorenzo Puri, Franco Locatelli, Daniela Palacios, Rossella Rota

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Invasive neuroendocrine carcinoma of the breast: a population-based study from the surveillance, epidemiology and end results (SEER) database

Jun Wang, Bing Wei, Constance T Albarracin, Jianhua Hu, Susan C Abraham, Yun Wu

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Treatment of gastric peritoneal carcinomatosis by combining complete surgical resection of lesions and intraperitoneal immunotherapy using catumaxomab

Diane Goéré, Nathalie Gras-Chaput, Anne Aupérin, Caroline Flament, Christophe Mariette, Olivier Glehen, Laurence Zitvogel, Dominique Elias

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Knowledge, awareness and attitudes about cervical cancer among women attending or not an HIV treatment center in Lao PDR

Chanvilay SICHANH, Fabrice QUET, Phetsavanh CHANTHAVILAY, Joeffroy DIENDERE, Vatthanaphone LATTHAPHASAVANG, Christophe LONGUET, Yves BUISSON

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Study protocol: a randomised controlled trial of a theory-based online intervention to improve sun safety among Australian adults

Cathy M Cleary, Katherine M White, Ross McD Young, Anna L Hawkes, Stuart Leske, Louise C Starfelt, Kylie Wihardjo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Retrospective analysis of 104 histologically proven adult brainstem gliomas: clinical symptoms, therapeutic approaches and prognostic factors

Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel, Guido Nikkhah

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Nuclear location of tumor suppressor protein maspin inhibits proliferation of breast cancer cells without affecting proliferation of normal epithelial cells

Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel, Ryszard Rzepecki

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Androgen receptor CAG repeats, non-random X chromosome inactivation, and loss of heterozygosity at Xq25 in relation to breast cancer risk

Hui-Tzu Chen, Yao-Chung Wu, Shou-Tung Chen, Hsien-Chang Tsai, Yi-Chih Chien

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells

Bin Peng, Xue Zhang, Fanfan Cao, Ying Wang, Limin Xu, Lu Cao, Chunxin Yang, Maoquan Li, Georges Uzan, Denghai Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pharmacological inhibition of poly(ADP-ribose) polymerase-1 modulates resistance of human glioblastoma stem cells to temozolomide

Lucio Tentori, Lucia Ricci-Vitiani, Alessia Muzi, Fabio Ciccarone, Federica Pelacchi, Roberta Calabrese, Daniele Runci, Roberto Pallini, Paola Caiafa, Grazia Graziani

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumor cells with low proteasome subunit expression predict overall survival in head and neck cancer patients

Chann Lagadec, Erina Vlashi, Sunita Bhuta, Chi Lai, Paul Mischel, Martin Werner, Michael Henke, Frank Pajonk

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Methylene blue-assisted technique for harvesting lymph nodes after radical surgery for gastric cancer: a prospective randomized phase III study

Toru Aoyama, Takaki Yoshikawa, Satoshi Morita, Junya Shirai, Hirohito Fujikawa, Kenichi Iwasaki, Tsutomu Hayashi, Takashi Ogata, Haruhiko Cho, Norio Yukawa, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Akira Tsuburaya

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Primary localized rectal/pararectal gastrointestinal stromal tumors: results of surgical and multimodal therapy from the French Sarcoma group

Thanh-Khoa Huynh, Pierre Meeus, Philippe Cassier, Olivier Bouché, Sophie Lardière-Deguelte, Antoine Adenis, Thierry André, Julien Mancini, Olivier Collard, Michael Montemurro, Emmanuelle Bompas, Maria Rios, Nicolas Isambert, Didier Cupissol, Jean-Yves Blay, Florence Duffaud

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Histological review of skin cancers in African Albinos: a 10-year retrospective review

Samson Kimaiyo Kiprono, Baraka Michael Chaula, Helmut Beltraminelli

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increased paired box transcription factor 8 has a survival function in Glioma

Noelyn Hung, Yu-Jen Chen, Ahmad Taha, Magnus Olivecrona, Ronald Boet, Anna Wiles, Tracy Warr, Alisha Shaw, Ramona Eiholzer, Bruce C Baguley, Michael R Eccles, Antony W Braithwaite, Martin MacFarlane, Janice A Royds, Tania Slatter

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of phosphoenolpyruvate carboxykinase linked to chemoradiation susceptibility of human colon cancer cells

Ji-Won Park, Seung Cheol Kim, Won Ki Kim, Jun Pyu Hong, Kyung-Hee Kim, Hyun Yang Yeo, Jae Yong Lee, M Sun Kim, Jong Heon Kim, Se Young Yang, Dae Yong Kim, Jae Hwan Oh, Jae Youl Cho, Byong Chul Yoo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increasing rates of surgical treatment and preventing comorbidities may increase breast cancer survival for Aboriginal women

Rajah Supramaniam, Alison Gibberd, Anthony Dillon, David Eamon Goldsbury, Dianne L O’Connell

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cyr61 Expression is associated with prognosis in patients with colorectal cancer

Dongjun Jeong, Suhak Heo, Tae Sung Ahn, Sookyoung Lee, Soyoung Park, Hyungjoo Kim, Doosan Park, Sang Byung Bae, Sung Soo Lee, Moon Soo Lee, Chang-Jin Kim, Moo Jun Baek

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Presence of intratumoral platelets is associated with tumor vessel structure and metastasis

Rong Li, Meiping Ren, Ni Chen, Mao Luo, Xin Deng, Jiyi Xia, Guang Yu, Jinbo Liu, Bing He, Xu Zhang, Zhuo Zhang, Xiao Zhang, Bing Ran, Jianbo Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Zoledronic acid inhibits pulmonary metastasis dissemination in a preclinical model of Ewing’s sarcoma via inhibition of cell migration

Guillaume Odri, Pui-Pui Kim, François Lamoureux, Céline Charrier, Séverine Battaglia, Jérôme Amiaud, Dominique Heymann, François Gouin, Françoise Redini

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Ovarian cancer symptom awareness and anticipated delayed presentation in a population sample

Kate E Brain, Stephanie Smits, Alice E Simon, Lindsay J Forbes, Chris Roberts, Iain J Robbé, John Steward, Ceri White, Richard D Neal, Jane Hanson

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Metformin enhances tamoxifen-mediated tumor growth inhibition in ER-positive breast carcinoma

Ji Ma, Yan Guo, Suning Chen, Cuiping Zhong, Yan Xue, Yuan Zhang, Xiaofeng Lai, Yifang Wei, Shentong Yu, Jian Zhang, Wenchao Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification and characterization of cancer stem cells in human head and neck squamous cell carcinoma

Jing Han, Toshio Fujisawa, Syed R Husain, Raj K Puri

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Therapeutic effects of lentivirus-mediated shRNA targeting of cyclin D1 in human gastric cancer

Jin-Hee Seo, Eui-Suk Jeong, Yang-Kyu Choi

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Can an alert in primary care electronic medical records increase participation in a population-based screening programme for colorectal cancer? COLO-ALERT, a randomised clinical trial

Carolina Guiriguet-Capdevila, Laura Muñoz-Ortiz, Irene Rivero-Franco, Carme Vela-Vallespín, Mercedes Vilarrubí-Estrella, Miquel Torres-Salinas, Jaume Grau-Cano, Andrea Burón-Pust, Cristina Hernández-Rodríguez, Antonio Fuentes-Peláez, Dolores Reina-Rodríguez, Rosa De León-Gallo, Leonardo Mendez-Boo, Pere Torán-Monserrat

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Outcome after intensity modulated radiotherapy for anaplastic thyroid carcinoma

Xiayun He, Duanshu Li, Chaosu Hu, Zhuoying Wang, Hongmei Ying, Yi Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Factors associated with work disability in employed cancer survivors at 24-month sick leave

Peter van Muijen, Saskia FA Duijts, Karin Bonefaas-Groenewoud, Allard J van der Beek, Johannes R Anema

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Stem cell Transplantation for Eradication of Minimal PAncreatic Cancer persisting after surgical Excision (STEM PACE Trial, ISRCTN47877138): study protocol for a phase II study

Friedrich H Schmitz-Winnenthal, Thomas Schmidt, Monika Lehmann, Philipp Beckhove, Meinhard Kieser, Anthony D Ho, Peter Dreger, Markus W Büchler

01.12.2014 | Technical advance | Ausgabe 1/2014 Open Access

Optimisation of an immunohistochemistry method for the determination of androgen receptor expression levels in circulating tumour cells

Jeffrey Cummings, Robert Sloane, Karen Morris, Cong Zhou, Matt Lancashire, David Moore, Tony Elliot, Noel Clarke, Caroline Dive

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Effect of physical therapy on breast cancer related lymphedema: protocol for a multicenter, randomized, single-blind, equivalence trial

Mette Tambour, Berit Tange, Robin Christensen, Bibi Gram

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Complete pathologic response of HER2-positive breast cancer liver metastasis with dual Anti-HER2 antagonism

Hans F Schoellhammer, Felicia Hsu, Courtney Vito, Peiguo Chu, Jinha Park, James Waisman, Joseph Kim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A phase II study of cisplatin with intravenous and oral vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy with oral vinorelbine and cisplatin for locally advanced non-small cell lung cancer

Delphine Lerouge, Alain Rivière, Eric Dansin, Christos Chouaid, Cécile Dujon, Roland Schott, Armelle Lavole, Vincent Le Pennec, Elizabeth Fabre, Jacky Crequit, Francis Martin, Stéphanie Dehette, Pierre Fournel, Bénédicte Precheur-Agulhon, Eric Lartigau, Gérard Zalcman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer

Annika N Alexopoulou, Colan M Ho-Yen, Vassilis Papalazarou, George Elia, J Louise Jones, Kairbaan Hodivala-Dilke

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Randomized controlled trial to evaluate the effects of combined progressive exercise on metabolic syndrome in breast cancer survivors: rationale, design, and methods

Christina M Dieli-Conwright, Joanne E Mortimer, E Todd Schroeder, Kerry Courneya, Wendy Demark-Wahnefried, Thomas A Buchanan, Debu Tripathy, Leslie Bernstein

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

p21 and CD166 as predictive markers of poor response and outcome after fluorouracil-based chemoradiotherapy for the patients with rectal cancer

Sung Hoon Sim, Mi-Hyun Kang, Yu Jung Kim, Keun-Wook Lee, Duck-Woo Kim, Sung-Bum Kang, Keun-Yong Eom, Jae-Sung Kim, Hye Seung Lee, Jee Hyun Kim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of novel signaling components in N,N’-Dinitrosopiperazine-mediated metastasis of nasopharyngeal Carcinoma by quantitative phosphoproteomics

Damao Huang, Yuejin Li, Na Liu, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan, Faqing Tang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluation of protein biomarkers of prostate cancer aggressiveness

Anthony E Rizzardi, Nikolaus K Rosener, Joseph S Koopmeiners, Rachel Isaksson Vogel, Gregory J Metzger, Colleen L Forster, Lauren O Marston, Jessica R Tiffany, James B McCarthy, Eva A Turley, Christopher A Warlick, Jonathan C Henriksen, Stephen C Schmechel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Changes in period and cohort effects on haematological cancer mortality in Spain, 1952-2006

Roberto Pastor-Barriuso, Gonzalo López-Abente

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Space-time clusters of breast cancer using residential histories: A Danish case–control study

Rikke Baastrup Nordsborg, Jaymie R Meliker, Annette Kjær Ersbøll, Geoffrey M Jacquez, Aslak Harbo Poulsen, Ole Raaschou-Nielsen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Met receptor-induced Grb2 or Shc signals both promote transformation of intestinal epithelial cells, albeit they are required for distinct oncogenic functions

Véronique Pomerleau, Mélissa Landry, Jimmy Bernier, Pierre H Vachon, Caroline Saucier

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Study protocol of the RAND-study: a multicenter, prospective cohort study investigating response and adherence to nilotinib treatment in chronic myeloid leukemia

Christel CLM Boons, Eleonora L Swart, Lonneke Timmers, Peter M van de Ven, Jeroen JWM Janssen, Jacqueline G Hugtenburg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

NILCO biomarkers in breast cancer from Chinese patients

Laronna S Colbert, Kaamilah Wilson, Sungjin Kim, Yuan Liu, Gabriela Oprea-Ilies, Corey Gillespie, Toi Dickson, Gale Newman, Ruben Rene Gonzalez-Perez

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma

Chantal van de Schootbrugge, Elisabeth MJ Schults, Johan Bussink, Paul N Span, Reidar Grénman, Ger JM Pruijn, Johannes HAM Kaanders, Wilbert C Boelens

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The expression of Dicer and Drosha in matched normal tissues, tumours and lymph node metastases in triple negative breast cancer

Kelly A Avery-Kiejda, Stephen G Braye, John F Forbes, Rodney J Scott

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic and predictive value of cathepsin X in serum from colorectal cancer patients

Tjaša Vižin, Ib Jarle Christensen, Michael Wilhelmsen, Hans Jørgen Nielsen, Janko Kos

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway

Runfa Bao, Yijun Shu, Xiangsong Wu, Hao Weng, Qian Ding, Yang Cao, Maolan Li, Jiasheng Mu, Wenguang Wu, Qichen Ding, Zhujun Tan, Tianyu Liu, Lin Jiang, Yunping Hu, Jianfeng Gu, Yingbin Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho

Xu-Jun He, Ying-Yu Ma, Sheng Yu, Xiao-Ting Jiang, Yi-Ding Lu, Liang Tao, Hua-Ping Wang, Zhi-Ming Hu, Hou-Quan Tao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Impairment of cognitive functioning during Sunitinib or Sorafenib treatment in cancer patients: a cross sectional study

Sasja F Mulder, Dirk Bertens, Ingrid ME Desar, Kris CP Vissers, Peter FA Mulders, Cornelis JA Punt, Dick-Johan van Spronsen, Johan F Langenhuijsen, Roy PC Kessels, Carla ML van Herpen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Study of the cytotoxicity of asiaticoside on rats and tumour cells

Fatma J Al-Saeedi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Primary small cell carcinoma of the esophagus: clinicopathological study of 44 cases

Wei-Wei Chen, Feng Wang, Dong-Sheng Zhang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Miao-Zhen Qiu, Chao Ren, Xiao-Li Wei, Wen-Jing Wu, Yu-Hong Li, Rui-Hua Xu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The cost of lost productivity due to premature cancer-related mortality: an economic measure of the cancer burden

Paul A Hanly, Linda Sharp

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Systemic neutralization of IL-17A significantly reduces breast cancer associated metastasis in arthritic mice by reducing CXCL12/SDF-1 expression in the metastatic niches

Lopamudra Das Roy, Mahnaz Sahraei, Jorge L Schettini, Helen E Gruber, Dahlia M Besmer, Pinku Mukherjee

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A retrospective analysis of survival and prognostic factors of male breast cancer from a single center

Amr A Soliman, Adel T Denewer, Wael El-Sadda, Ali H Abdel-Aty, Basel Refky

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Feeling well and talking about sex: psycho-social predictors of sexual functioning after cancer

Janette Perz, Jane M Ussher, Emilee Gilbert, The Australian Cancer and Sexuality Study Team

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Breast density and mode of detection in relation to breast cancer specific survival: a cohort study

Åsa Olsson, Hanna Sartor, Signe Borgquist, Sophia Zackrisson, Jonas Manjer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Is provider type associated with cancer screening and prevention: advanced practice registered nurses, physician assistants, and physicians

Deanna Kepka, Alexandria Smith, Christopher Zeruto, K Robin Yabroff

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression

Isabelle Matte, Denis Lane, Marianne Boivin, Claudine Rancourt, Alain Piché

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy

Giles W Robinson, Brent A Orr, Amar Gajjar

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Activation of Akt1 accelerates carcinogen-induced tumorigenesis in mammary gland of virgin and post-lactating transgenic mice

Yanyuan Wu, Juri Kim, Yayha Elshimali, Marianna Sarkissyan, Jaydutt V Vadgama

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Serum soluble ST2 is associated with ER-positive breast cancer

Da-peng Lu, Xiang-yu Zhou, Lu-tian Yao, Cai-gang Liu, Wei Ma, Feng Jin, Yun-fei Wu

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Improving sexual health in men with prostate cancer: randomised controlled trial of exercise and psychosexual therapies

Prue Cormie, Suzanne K Chambers, Robert U Newton, Robert A Gardiner, Nigel Spry, Dennis R Taaffe, David Joseph, M Akhlil Hamid, Peter Chong, David Hughes, Kyra Hamilton, Daniel A Galvão

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-484 is more highly expressed in serum of early breast cancer patients compared to healthy volunteers

Silvia Zearo, Edward Kim, Ying Zhu, Jing Ting Zhao, Stan B Sidhu, Bruce G Robinson, Patsy SH Soon

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors

Alena M Pfeil, Christof Vulsteke, Robert Paridaens, Anne-Sophie Dieudonné, Ruth Pettengell, Sigrid Hatse, Patrick Neven, Diether Lambrechts, Thomas D Szucs, Matthias Schwenkglenks, Hans Wildiers

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Ion Prostate Irradiation (IPI) – a pilot study to establish the safety and feasibility of primary hypofractionated irradiation of the prostate with protons and carbon ions in a raster scan technique

Gregor Habl, Gencay Hatiboglu, Lutz Edler, Matthias Uhl, Sonja Krause, Matthias Roethke, Heinz P Schlemmer, Boris Hadaschik, Juergen Debus, Klaus Herfarth

01.12.2014 | Debate | Ausgabe 1/2014 Open Access

DNA damage response and DNA repair – dog as a model?

Nicole Grosse, Barbara van Loon, Carla Rohrer Bley

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Intensified chemotherapy and simultaneous treatment with heparin in outpatients with pancreatic cancer – the CONKO 004 pilot trial

Uwe Pelzer, Andreas Hilbig, Jens M Stieler, Marcus Bahra, Marianne Sinn, Bernhard Gebauer, Bernd Dörken, Hanno Riess

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis

Lei Wang, Rui Wang, Yunjian Pan, Yihua Sun, Jie Zhang, Haiquan Chen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin

Brian Hutzen, Hemant Kumar Bid, Peter J Houghton, Christopher R Pierson, Kimerly Powell, Anna Bratasz, Corey Raffel, Adam W Studebaker

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Rationale and design of the iPap trial: a randomized controlled trial of home-based HPV self-sampling for improving participation in cervical screening by never- and under-screened women in Australia

Farhana Sultana, Dallas R English, Julie A Simpson, Julia ML Brotherton, Kelly Drennan, Robyn Mullins, Stella Heley, C David Wrede, Marion Saville, Dorota M Gertig

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion

Kun Cai, Kirk Mulatz, Ryan Ard, Thanh Nguyen, Stephen H Gee

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Standardization of D2 lymphadenectomy and surgical quality control (KLASS-02-QC): a prospective, observational, multicenter study [NCT01283893]

Hyoung-Il Kim, Hoon Hur, Youn Nam Kim, Hyuk-Joon Lee, Min-Chan Kim, Sang-Uk Han, Woo Jin Hyung

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

New malignancies after squamous cell carcinoma and melanomas: a population-based study from Norway

Trude E Robsahm, Margaret R Karagas, Judy R Rees, Astri Syse

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Systematic assessment of prognostic gene signatures for breast cancer shows distinct influence of time and ER status

Xi Zhao, Einar Andreas Rødland, Therese Sørlie, Hans Kristian Moen Vollan, Hege G Russnes, Vessela N Kristensen, Ole Christian Lingjærde, Anne-Lise Børresen-Dale

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Closing the global cancer divide- performance of breast cancer care services in a middle income developing country

Gerard CC Lim, Emran N Aina, Soon K Cheah, Fuad Ismail, Gwo F Ho, Lye M Tho, Cheng H Yip, Nur A Taib, Kwang J Chong, Jayendran Dharmaratnam, Matin M Abdullah, Ahmad K Mohamed, Kean F Ho, Kananathan Ratnavelu, Chiao M Lim, Kin W Leong, Ibrahim A Wahid, Teck O Lim, for the HPMRS Breast Cancer Study Group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma

Ramón Martínez, F Javier Carmona, Miguel Vizoso, Veit Rohde, Matthias Kirsch, Gabriele Schackert, Santiago Ropero, Werner Paulus, Alonso Barrantes, Antonio Gomez, Manel Esteller

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Loss of MTUS1/ATIP expression is associated with adverse outcome in advanced bladder carcinomas: data from a retrospective study

Anja Rogler, Sabine Hoja, Johannes Giedl, Arif B Ekici, Sven Wach, Helge Taubert, Peter J Goebell, Bernd Wullich, Michael Stöckle, Jan Lehmann, Sabrina Petsch, Arndt Hartmann, Robert Stoehr

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical research of genetically modified dendritic cells in combination with cytokine-induced killer cell treatment in advanced renal cancer

Danhong Wang, Bin Zhang, Haiyan Gao, Guoliang Ding, Qiong Wu, Jinchao Zhang, Li Liao, Hu Chen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer

Piotr Tymoszuk, Pornpimol Charoentong, Hubert Hackl, Rita Spilka, Elisabeth Müller-Holzner, Zlatko Trajanoski, Peter Obrist, Françoise Revillion, Jean-Philippe Peyrat, Heidi Fiegl, Wolfgang Doppler

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cost-effectiveness of family history-based colorectal cancer screening in Australia

Driss A Ouakrim, Alex Boussioutas, Trevor Lockett, John L Hopper, Mark A Jenkins

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Feasibility of intensity-modulated and image-guided radiotherapy for locally advanced esophageal cancer

Nam P Nguyen, Siyoung Jang, Jacqueline Vock, Vincent Vinh-Hung, Alexander Chi, Paul Vos, Judith Pugh, Richard A Vo, Misty Ceizyk, Anand Desai, Lexie Smith-Raymond, the International Geriatric Radiotherapy Group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

Martin C Boonstra, Floris PR Verbeek, Andrew P Mazar, Hendrica AJM Prevoo, Peter JK Kuppen, Cornelis JH van de Velde, Alexander L Vahrmeijer, Cornelis FM Sier

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Triptolide induces apoptotic cell death of human cholangiocarcinoma cells through inhibition of myeloid cell leukemia-1

Xiwei Ding, Bin Zhang, Qingshan Pei, Jianmei Pan, Shuling Huang, Yan Yang, Zhu Zhu, Ying Lv, Xiaoping Zou

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Circulating cell-free methylated DNA and lactate dehydrogenase release in colorectal cancer

Alexander B Philipp, Dorothea Nagel, Petra Stieber, Rolf Lamerz, Isabel Thalhammer, Andreas Herbst, Frank T Kolligs

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression microarray identifies the unliganded glucocorticoid receptor as a regulator of gene expression in mammary epithelial cells

Heather D Ritter, Christopher R Mueller

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype

Zunling Li, Yanxia Guo, Hanming Jiang, Tingguo Zhang, Changzhu Jin, Charles YF Young, Huiqing Yuan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Capecitabine in combination with oxaliplatin and bevacizumab (AXELOX) as 1st line treatment for fit and vulnerable elderly patients (aged >70 years) with metastatic colorectal cancer (mCRC): a multicenter phase II study of the Hellenic Oncology Research Group (HORG)

Lambros Vamvakas, Alexios Matikas, Athanasios Karampeazis, Dora Hatzidaki, Stelios Kakolyris, Charalampos Christophylakis, Ioannis Boukovinas, Aris Polyzos, Vassilis Georgoulias, John Souglakos

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inhibition of autophagy enhances the cytotoxic effect of PA-MSHA in breast cancer

Wen-Huan Xu, Zhe-Bin Liu, Yi-Feng Hou, Qi Hong, Da-Li Hu, Zhi-Ming Shao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Hepatitis B spliced protein (HBSP) promotes the carcinogenic effects of benzo [alpha] pyrene by interacting with microsomal epoxide hydrolase and enhancing its hydrolysis activity

Jin-Yan Chen, Wan-Nan Chen, Bo-Yan Jiao, Wan-Song Lin, Yun-Li Wu, Ling-Ling Liu, Xu Lin

01.12.2014 | Correspondence | Ausgabe 1/2014 Open Access

The randomised clinical trial and the hazard ratio – medical research’s Emperor’s New Clothes?

Richard Stephens, David Stewart

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Decrease social inequalities return-to-work: development and design of a randomised controlled trial among women with breast cancer

Clémence Vidor, Ariane Leroyer, Véronique Christophe, Mélanie Seillier, Jérome Foncel, Justine Van de Maële, Jacques Bonneterre, Sophie Fantoni

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging

Kristina Buder, Constantin Lapa, Michael C Kreissl, Andreas Schirbel, Ken Herrmann, Alexander Schnack, Eva-Bettina Bröcker, Matthias Goebeler, Andreas K Buck, Jürgen C Becker

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Development of a scale to assess cancer stigma in the non-patient population

Laura AV Marlow, Jane Wardle

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

N-nitroso-N-ethylurea activates DNA damage surveillance pathways and induces transformation in mammalian cells

Satish Bodakuntla, Libi Anandi V, Surojit Sural, Prasad Trivedi, Mayurika Lahiri

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Conformational changes and translocation of tissue-transglutaminase to the plasma membranes: role in cancer cell migration

Ambrish Kumar, Jianjun Hu, Holly A LaVoie, Kenneth B Walsh, Donald J DiPette, Ugra S Singh

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Second primary cancer risk - the impact of applying different definitions of multiple primaries: results from a retrospective population-based cancer registry study

Aishah Coyte, David S Morrison, Philip McLoone

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation

Marja Moerkens, Yinghui Zhang, Lynn Wester, Bob van de Water, John HN Meerman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A role for PAX8 in the tumorigenic phenotype of ovarian cancer cells

Tina Di Palma, Valeria Lucci, Tiziana de Cristofaro, Maria Grazia Filippone, Mariastella Zannini

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A novel oxygen carrier “YQ23” suppresses the liver tumor metastasis by decreasing circulating endothelial progenitor cells and regulatory T cells

Chang Xian Li, Bing L Wong, Chang Chun Ling, Yuen Yuen Ma, Yan Shao, Wei Geng, Xiang Qi, Sze Hang Lau, Sui Yi Kwok, Na Wei, Fei Chuen Tzang, Kevin TP Ng, Xiao Bing Liu, Chung Mau Lo, Kwan Man

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Long-term use of metformin and the molecular subtype in invasive breast carcinoma patients – a retrospective study of clinical and tumor characteristics

Nikola Besic, Nika Satej, Ivica Ratosa, Andreja Gojkovic Horvat, Tanja Marinko, Barbara Gazic, Rok Petric

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays

Britta Weber, Peter Meldgaard, Henrik Hager, Lin Wu, Wen Wei, Julie Tsai, Azza Khalil, Ebba Nexo, Boe S Sorensen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Ganglioside GD2 in reception and transduction of cell death signal in tumor cells

Igor I Doronin, Polina A Vishnyakova, Irina V Kholodenko, Eugene D Ponomarev, Dmitry Y Ryazantsev, Irina M Molotkovskaya, Roman V Kholodenko

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Down-regulation of sirtuin 3 is associated with poor prognosis in hepatocellular carcinoma after resection

Jia-Xing Wang, Yong Yi, Yi-Wei Li, Xiao-Yan Cai, Hong-Wei He, Xiao-Chun Ni, Jian Zhou, Yun-Feng Cheng, Jian-Jun Jin, Jia Fan, Shuang-Jian Qiu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prevalence of TPMT and ITPA gene polymorphisms and effect on mercaptopurine dosage in Chilean children with acute lymphoblastic leukemia

Mauricio J Farfan, Carolina Salas, Cristina Canales, Felipe Silva, Milena Villarroel, Katherine Kopp, Juan P Torres, María E Santolaya, Jorge Morales

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Transarterial infusion chemotherapy with cisplatin plus S-1 for hepatocellular carcinoma treatment: a phase I trial

Tetsuji Terazawa, Shunsuke Kondo, Hiroko Hosoi, Chigusa Morizane, Satoshi Shimizu, Shuichi Mitsunaga, Masafumi Ikeda, Hideki Ueno, Takuji Okusaka

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling

María D Cuenca-López, Juan C Montero, Jorge C Morales, Aleix Prat, Atanasio Pandiella, Alberto Ocana

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDHhighCD44+ phenotype and sphere-forming capacity

Lourdes Cortes-Dericks, Laurene Froment, Ruben Boesch, Ralph Alexander Schmid, Golnaz Karoubi

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Multiple scalp metastases from colonic neuroendocrine carcinoma: case report and literature review

Shao-min Wang, Meng Ye, Shu-min Ni

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

The SystHERs registry: an observational cohort study of treatment patterns and outcomes in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer

Debu Tripathy, Hope S Rugo, Peter A Kaufman, Sandra Swain, Joyce O’Shaughnessy, Mohammad Jahanzeb, Ginny Mason, Mary Beattie, Bongin Yoo, Catherine Lai, Anthony Masaquel, Sara Hurvitz

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure

Ovidiu Balacescu, Loredana Balacescu, Oana Tudoran, Nicolae Todor, Meda Rus, Rares Buiga, Sergiu Susman, Bogdan Fetica, Laura Pop, Laura Maja, Simona Visan, Claudia Ordeanu, Ioana Berindan-Neagoe, Viorica Nagy

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Large cell anaplastic medulloblastoma metastatic to the scalp: tumor and derived stem-like cells features

Angela Mastronuzzi, Evelina Miele, Agnese Po, Manila Antonelli, Francesca Romana Buttarelli, Giovanna Stefania Colafati, Francesca del Bufalo, Roberta Faedda, Gian Paolo Spinelli, Andrea Carai, Felice Giangaspero, Alberto Gulino, Franco Locatelli, Elisabetta Ferretti

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

The muscle mass, omega-3, diet, exercise and lifestyle (MODEL) study – a randomised controlled trial for women who have completed breast cancer treatment

Cameron McDonald, Judy Bauer, Sandra Capra, Joseph Coll

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma

Zhen Liu, Xiaobin Long, Cheng Chao, Chen Yan, Qiangyun Wu, Shengni Hua, Yajie Zhang, Aibing Wu, Weiyi Fang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover

Aleksandra B Adomas, Sara A Grimm, Christine Malone, Motoki Takaku, Jennifer K Sims, Paul A Wade

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Vascular measurements correlate with estrogen receptor status

Mark C Lloyd, Khalid O Alfarouk, Daniel Verduzco, Marilyn M Bui, Robert J Gillies, Muntaser E Ibrahim, Joel S Brown, Robert A Gatenby

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic value of secreted phosphoprotein-1 in pleural effusion associated with non-small cell lung cancer

He Zhang, Hong-bing Liu, Dong-mei Yuan, Zhao-feng Wang, Yun-fen Wang, Yong Song

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Microcalcifications in breast cancer: an active phenomenon mediated by epithelial cells with mesenchymal characteristics

Manuel Scimeca, Elena Giannini, Chiara Antonacci, Chiara Adriana Pistolese, Luigi Giusto Spagnoli, Elena Bonanno

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Role of malignant ascites on human mesothelial cells and their gene expression profiles

Isabelle Matte, Denis Lane, Dimcho Bachvarov, Claudine Rancourt, Alain Piché

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of breast cancer patients with a high risk of developing brain metastases: a single-institutional retrospective analysis

Volker Rudat, Hamdan El-Sweilmeen, Iris Brune-Erber, Alaa Ahmad Nour, Nidal Almasri, Saleh Altuwaijri, Elias Fadel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

CC-Chemokine receptor CCR7: a key molecule for lymph node metastasis in esophageal squamous cell carcinoma

Tomoyuki Irino, Hiroya Takeuchi, Sachiko Matsuda, Yoshiro Saikawa, Hirofumi Kawakubo, Norihito Wada, Tsunehiro Takahashi, Rieko Nakamura, Kazumasa Fukuda, Tai Omori, Yuko Kitagawa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The prognostic effect of perineural invasion in esophageal squamous cell carcinoma

Jie-Wei Chen, Jing-Dun Xie, Yi-Hong Ling, Peng Li, Shu-Mei Yan, Shao-Yan Xi, Rong-Zhen Luo, Jing-Ping Yun, Dan Xie, Mu-Yan Cai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Female breast cancer survival in Qidong, China, 1972–2011: a population-based study

Jian Zhu, Jian-Guo Chen, Yong-Sheng Chen, Yong-Hui Zhang, Lu-Lu Ding, Tao-Yang Chen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Randomized phase II study of pemetrexed/cisplatin with or without axitinib for non-squamous non-small-cell lung cancer

Chandra P Belani, Nobuyuki Yamamoto, Igor M Bondarenko, Artem Poltoratskiy, Silvia Novello, Jie Tang, Paul Bycott, Andreas G Niethammer, Antonella Ingrosso, Sinil Kim, Giorgio V Scagliotti

01.12.2014 | Review | Ausgabe 1/2014 Open Access

Sodium iodide symporter (NIS) in extrathyroidal malignancies: focus on breast and urological cancer

Salvatore Micali, Stefania Bulotta, Cinzia Puppin, Angelo Territo, Michele Navarra, Giampaolo Bianchi, Giuseppe Damante, Sebastiano Filetti, Diego Russo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Using technology to deliver cancer follow-up: a systematic review

Rebekah Dickinson, Susan Hall, Jenny E Sinclair, Christine Bond, Peter Murchie

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Genomic profile of ovarian carcinomas

Francesca Micci, Lisbeth Haugom, Vera M Abeler, Ben Davidson, Claes G Tropé, Sverre Heim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Brain cancer mortality in an agricultural and a metropolitan region of Rio de Janeiro, Brazil: a population-based, age-period-cohort study, 1996–2010

Adalberto Luiz Miranda Filho, Rosalina Jorge Koifman, Sergio Koifman, Gina Torres Rego Monteiro

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Bevacizumab with 5-fluorouracil, leucovorin, and oxaliplatin versus bevacizumab with capecitabine and oxaliplatin for metastatic colorectal carcinoma: results of a large registry-based cohort analysis

Tomas Buchler, Tomas Pavlik, Bohuslav Melichar, Zbynek Bortlicek, Zuzana Usiakova, Ladislav Dusek, Igor Kiss, Milan Kohoutek, Vera Benesova, Rostislav Vyzula, Jitka Abrahamova, Radka Obermannova

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Delivery of health care at the end of life in cancer patients of four swiss cantons: a retrospective database study (SAKK 89/09)

Klazien W Matter-Walstra, Rita Achermann, Roland Rapold, Dirk Klingbiel, Andrea Bordoni, Silvia Dehler, Gernot Jundt, Isabelle Konzelmann, Kerri M Clough-Gorr, Thomas D Szucs, Matthias Schwenkglenks, Bernhard C Pestalozzi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Metformin induces an intracellular reductive state that protects oesophageal squamous cell carcinoma cells against cisplatin but not copper-bis(thiosemicarbazones)

Leonard Howard Damelin, Rupal Jivan, Robin Bruce Veale, Amanda Louise Rousseau, Demetra Mavri-Damelin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

RNA-binding protein RNPC1: acting as a tumor suppressor in breast cancer

Jin-Qiu Xue, Tian-Song Xia, Xiu-Qing Liang, Wenbin Zhou, Lin Cheng, Liang Shi, Ying Wang, Qiang Ding

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

Dong-Mei Qiu, Gui-Lan Wang, Li Chen, Yu-Yin Xu, Song He, Xiao-Lei Cao, Jing Qin, Jia-Ming Zhou, Yi-Xin Zhang, Qun E

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Trends in oral cavity, pharyngeal, oesophageal and gastric cancer mortality rates in Spain, 1952–2006: an age-period-cohort analysis

Daniel Seoane-Mato, Nuria Aragonés, Eva Ferreras, Javier García-Pérez, Marta Cervantes-Amat, Pablo Fernández-Navarro, Roberto Pastor-Barriuso, Gonzalo López-Abente

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Gastric Helicobacter pylori infection associates with an increased risk of colorectal polyps in African Americans

Hassan Brim, Marwah Zahaf, Adeyinka O Laiyemo, Mehdi Nouraie, Guillermo I Pérez-Pérez, Duane T Smoot, Edward Lee, Hadie Razjouyan, Hassan Ashktorab

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity

Sung-Jun Ko, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Tae Jung Kim, Kyung Won Lee, Kwhanmien Kim, Sanghoon Jheon, Hyojin Kim, Jae Ho Lee, Choon-Taek Lee

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Population-based incidence trends of oropharyngeal and oral cavity cancers by sex among the poorest and underprivileged populations

Ajit Auluck, Blake Byron Walker, Greg Hislop, Scott A Lear, Nadine Schuurman, Miriam Rosin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Decreased expression of long noncoding RNA GAS5 indicates a poor prognosis and promotes cell proliferation in gastric cancer

Ming Sun, Fei-yan Jin, Rui Xia, Rong Kong, Jin-hai Li, Tong-peng Xu, Yan-wen Liu, Er-bao Zhang, Xiang-hua Liu, Wei De

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Does access to a colorectal cancer screening website and/or a nurse-managed telephone help line provided to patients by their family physician increase fecal occult blood test uptake?: results from a pragmatic cluster randomized controlled trial

Kathleen Clouston, Alan Katz, Patricia J Martens, Jeff Sisler, Donna Turner, Michelle Lobchuk, Susan McClement, Gary Crow, the CIHR/CCMB Team in Primary Care Oncology (PCO-NET)

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis

Victoria Moneo, Beatriz G Serelde, Carmen Blanco-Aparicio, Ramon Diaz-Uriarte, Pablo Avilés, Gemma Santamaría, Juan C Tercero, Carmen Cuevas, Amancio Carnero

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Demethylation of the miR-146a promoter by 5-Aza-2’-deoxycytidine correlates with delayed progression of castration-resistant prostate cancer

Xiaolu Wang, Haitao Gao, Lixin Ren, Junfei Gu, Yanping Zhang, Yong Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors

Ge Zhang, Makito Miyake, Adrienne Lawton, Steve Goodison, Charles J Rosser

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Small-sized polymeric micelles incorporating docetaxel suppress distant metastases in the clinically-relevant 4T1 mouse breast cancer model

Yunfei Li, Mingji Jin, Shuai Shao, Wei Huang, Feifei Yang, Wei Chen, Shenghua Zhang, Guimin Xia, Zhonggao Gao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden

Khalid Abubaker, Rodney B Luwor, Hongjian Zhu, Orla McNally, Michael A Quinn, Christopher J Burns, Erik W Thompson, Jock K Findlay, Nuzhat Ahmed

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Smoking increases rectal cancer risk to the same extent in women as in men: results from a Norwegian cohort study

Ranjan Parajuli, Eivind Bjerkaas, Aage Tverdal, Loïc Le Marchand, Elisabete Weiderpass, Inger T Gram

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

YB-1 regulates Sox2 to coordinately sustain stemness and tumorigenic properties in a phenotypically distinct subset of breast cancer cells

Karen Jung, Fang Wu, Peng Wang, Xiaoxia Ye, Bassam S Abdulkarim, Raymond Lai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumor-associated macrophage-derived IL-6 and IL-8 enhance invasive activity of LoVo cells induced by PRL-3 in a KCNN4 channel-dependent manner

Heyang Xu, Wei Lai, Yang Zhang, Lu Liu, Xingxi Luo, Yujie Zeng, Heng Wu, Qiusheng Lan, Zhonghua Chu

01.12.2014 | Hypothesis | Ausgabe 1/2014 Open Access

Epistemology of the origin of cancer: a new paradigm

Björn LDM Brücher, Ijaz S Jamall

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Indoleamine 2,3-dioxygenase (IDO) is frequently expressed in stromal cells of Hodgkin lymphoma and is associated with adverse clinical features: a retrospective cohort study

Ji-Young Choe, Ji Yun Yun, Yoon Kyoung Jeon, Se Hoon Kim, Gyeongsin Park, Joo Ryoung Huh, Sohee Oh, Ji Eun Kim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Predictors of recurrence free survival for patients with stage II and III colon cancer

Vassiliki L Tsikitis, David W Larson, Marianne Huebner, Christine M Lohse, Patricia A Thompson

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Diffuse large B cell lymphoma derived from nodular lymphocyte predominant Hodgkin lymphoma presents with variable histopathology

Sylvia Hartmann, Mine Eray, Claudia Döring, Tuula Lehtinen, Uta Brunnberg, Paula Kujala, Martine Vornanen, Martin-Leo Hansmann

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical relevance of breast cancer-related genes as potential biomarkers for oral squamous cell carcinoma

Toshima Z Parris, Luaay Aziz, Anikó Kovács, Shahin Hajizadeh, Szilárd Nemes, May Semaan, Chang Yan Chen, Per Karlsson, Khalil Helou

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Quantitative analysis of castration resistant prostate cancer progression through phosphoproteome signaling

Reynald M Lescarbeau, David L Kaplan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Use of NQO1 status as a selective biomarker for oesophageal squamous cell carcinomas with greater sensitivity to 17-AAG

Katie E Hadley, Denver T Hendricks

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

Carlos KH Wong, Wai-Lun Law, Yuk-Fai Wan, Jensen Tung-Chung Poon, Cindy Lo-Kuen Lam

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Genome instability in blood cells of a BRCA1 + breast cancer family

Fengxia Xiao, Yeong C Kim, Carrie Snyder, Hongxiu Wen, Pei Xian Chen, Jiangtao Luo, Dina Becirovic, Bradley Downs, Kenneth H Cowan, Henry Lynch, San Ming Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Higher incidence of premenopausal breast cancer in less developed countries; myth or truth?

Reza Ghiasvand, Hans-Olov Adami, Iraj Harirchi, Rahim Akrami, Kazem Zendehdel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Incidence and outcome for patients with occult lymph node involvement in T1 and T2 oral squamous cell carcinoma: a prospective study

Thomas Mücke, David A Mitchell, Stefan Wagenpfeil, Lucas M Ritschl, Klaus-Dietrich Wolff, Anastasios Kanatas

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Dexamethasone for the prevention of a pain flare after palliative radiotherapy for painful bone metastases: a multicenter double-blind placebo-controlled randomized trial

Paulien G Westhoff, Alexander de Graeff, Jenske I Geerling, Anna KL Reyners, Yvette M van der Linden

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Excellent local control with IOERT and postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis of a prospective trial

Falk Roeder, Burkhard Lehner, Thomas Schmitt, Bernd Kasper, Gerlinde Egerer, Oliver Sedlaczek, Carsten Grüllich, Gunhild Mechtersheimer, Patrick Wuchter, Frank W Hensley, Peter E Huber, Juergen Debus, Marc Bischof

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Serum concentration of alpha-1 antitrypsin is significantly higher in colorectal cancer patients than in healthy controls

Sergio Pérez-Holanda, Ignacio Blanco, Manuel Menéndez, Luis Rodrigo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Peripheral blood lymphocyte/monocyte ratio at the time of first relapse predicts outcome for patients with relapsed or primary refractory diffuse large B-cell lymphoma

Yan-Li Li, Kang-Sheng Gu, Yue-Yin Pan, Yang Jiao, Zhi-Min Zhai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Matrix metalloproteinase 12 is induced by heterogeneous nuclear ribonucleoprotein K and promotes migration and invasion in nasopharyngeal carcinoma

I-Che Chung, Lih-Chyang Chen, An-Ko Chung, Mei Chao, Hsin-Yi Huang, Chuen Hsueh, Ngan-Ming Tsang, Kai-Ping Chang, Ying Liang, Hsin-Pai Li, Yu-Sun Chang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Quantitative measurements of HER2 and phospho-HER2 expression: correlation with pathologic response to neoadjuvant chemotherapy and trastuzumab

Huan Cheng, Yalai Bai, William Sikov, Natalie Sinclair, Veerle Bossuyt, Maysa M Abu-Khalaf, Lyndsay N Harris, David L Rimm

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The chick chorioallantoic membrane as an in vivo xenograft model for Burkitt lymphoma

Marcel Klingenberg, Jürgen Becker, Sonja Eberth, Dieter Kube, Jörg Wilting

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Estrogen receptor α and aryl hydrocarbon receptor independent growth inhibitory effects of aminoflavone in breast cancer cells

Ashley M Brinkman, Jiacai Wu, Karen Ersland, Wei Xu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Temporal evolution in caveolin 1 methylation levels during human esophageal carcinogenesis

Zhe Jin, Liang Wang, Ziyi Cao, Yulan Cheng, Yan Gao, Xianling Feng, Si Chen, Huimin Yu, Wenjing Wu, Zhenfu Zhao, Ming Dong, Xiaojing Zhang, Jie Liu, Xinmin Fan, Yuriko Mori, Stephen J Meltzer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Diagnostic assessment by dynamic contrast-enhanced and diffusion-weighted magnetic resonance in differentiation of breast lesions under different imaging protocols

Hongmin Cai, Lizhi Liu, Yanxia Peng, Yaopan Wu, Li Li

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNAs define distinct human neuroblastoma cell phenotypes and regulate their differentiation and tumorigenicity

Leleesha Samaraweera, Kathryn B Grandinetti, Ruojun Huang, Barbara A Spengler, Robert A Ross

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Antagonism of Sorafenib and Regorafenib actions by platelet factors in hepatocellular carcinoma cell lines

Rosalba D’Alessandro, Maria G Refolo, Catia Lippolis, Grazia Giannuzzi, Nicola Carella, Caterina Messa, Aldo Cavallini, Brian I Carr

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

CA15-3 is a useful serum tumor marker for diagnostic integration of hybrid positron emission tomography with integrated computed tomography during follow-up of breast cancer patients

Mariarosaria Incoronato, Peppino Mirabelli, Onofrio Catalano, Marco Aiello, Chiara Parente, Andrea Soricelli, Emanuele Nicolai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Individual risk of cutaneous melanoma in New Zealand: developing a clinical prediction aid

Mary Jane Sneyd, Claire Cameron, Brian Cox

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Survival advantage of partial over radical nephrectomy in patients presenting with localized renal cell carcinoma

Frederik C Roos, Sandra Steffens, Kerstin Junker, Martin Janssen, Frank Becker, Gerd Wegener, Walburgis Brenner, Julie Steinestel, Thomas J Schnoeller, Mark Schrader, Rainer Hofmann, Joachim W Thüroff, Markus A Kuczyk, Heiko Wunderlich, Stefan Siemer, Arndt Hartmann, Michael Stöckle, Andres J Schrader, For the German Renal Cell Cancer Network

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Immunotherapy of hepatocellular carcinoma with small double-stranded RNA

Tatyana O Kabilova, Larisa V Kovtonyuk, Evgeniy V Zonov, Elena I Ryabchikova, Nelly A Popova, Valeriy P Nikolin, Vasiliy I Kaledin, Marina A Zenkova, Valentin V Vlassov, Elena L Chernolovskaya

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinicopathological analysis of thymic malignancies with a consistent retrospective database in a single institution: from Tokyo Metropolitan Cancer Center

Yusuke Okuma, Yukio Hosomi, Kageaki Watanabe, Yuko Yamada, Hirotoshi Horio, Yoshiharu Maeda, Tatsuru Okamura, Tsunekazu Hishima

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer

Nelma Pértega-Gomes, José R Vizcaíno, Jan Attig, Sarah Jurmeister, Carlos Lopes, Fátima Baltazar

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomic and immunological analysis

Chih-Ming Lu, Jen-Jie Lin, Han-Hsiang Huang, Ying-Chin Ko, Jue-Liang Hsu, Jiing-Chuan Chen, Zhong-Hao Din, Yu-Jen Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prevalence of gastrointestinal stromal tumour (GIST) in the United Kingdom at different therapeutic lines: an epidemiologic model

Justyna M Starczewska Amelio, Javier Cid Ruzafa, Kamal Desai, Spiros Tzivelekis, Dominic Muston, Javaria Mona Khalid, Philip Ashman, Andrew Maguire

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients

Liyun Miao, Yongsheng Wang, Suhua Zhu, Minke Shi, Yan Li, Jingjing Ding, Jun Yang, Qing Ye, Hourong Cai, Deping Zhang, Hongbing liu, Yong Song

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice

Mark Whitehead, Peter Öhlschläger, Fahad N Almajhdi, Leonor Alloza, Pablo Marzábal, Ann E Meyers, Inga I Hitzeroth, Edward P Rybicki

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Associations of hormone replacement therapy and oral contraceptives with risk of colorectal cancer defined by clinicopathological factors, beta-catenin alterations, expression of cyclin D1, p53, and microsatellite-instability

Jenny Brändstedt, Sakarias Wangefjord, Björn Nodin, Jakob Eberhard, Karin Jirström, Jonas Manjer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma

Siming Li, Yan Kong, Lu Si, Zhihong Chi, Chuanliang Cui, Xinan Sheng, Jun Guo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical implications of SPRR1A expression in diffuse large B-cell lymphomas: a prospective, observational study

Hao Zhang, Jiyue Gao, Zuowei Zhao, Man Li, Caigang Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cancer incidence in Ghana, 2012: evidence from a population-based cancer registry

Dennis O Laryea, Baffour Awuah, Yaw A Amoako, E Osei-Bonsu, Joslin Dogbe, Rita Larsen-Reindorf, Daniel Ansong, Kwasi Yeboah-Awudzi, Joseph K Oppong, Thomas O Konney, Kwame O Boadu, Samuel B Nguah, Nicholas A Titiloye, Nicholas O Frimpong, Fred K Awittor, Iman K Martin

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

The COLON study: Colorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that may influence colorectal tumour recurrence, survival and quality of life

Renate M Winkels, Renate C Heine-Bröring, Moniek van Zutphen, Suzanne van Harten-Gerritsen, Dieuwertje EG Kok, Fränzel JB van Duijnhoven, Ellen Kampman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

FCGR2A and FCGR3A polymorphisms and clinical outcome in metastatic colorectal cancer patients treated with first-line 5-fluorouracil/folinic acid and oxaliplatin +/- cetuximab

Janne B Kjersem, Eva Skovlund, Tone Ikdahl, Tormod Guren, Christian Kersten, Astrid M Dalsgaard, Mette K Yilmaz, Tone Fokstuen, Kjell M Tveit, Elin H Kure

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Investigation of HOXA9 promoter methylation as a biomarker to distinguish oral cancer patients at low risk of neck metastasis

Kenichiro Uchida, Ratna Veeramachaneni, Bing Huey, Aditi Bhattacharya, Brian L Schmidt, Donna G Albertson

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tumors induce coordinate growth of artery, vein, and lymphatic vessel triads

Alanna Ruddell, Alexandra Croft, Karen Kelly-Spratt, Momoko Furuya, Christopher J Kemp

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy

Annamaria Ruzzo, Vincenzo Catalano, Emanuele Canestrari, Elisa Giacomini, Daniele Santini, Giuseppe Tonini, Bruno Vincenzi, Giammaria Fiorentini, Mauro Magnani, Francesco Graziano

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells

Xing-dong Xu, Lan Yang, Li-yun Zheng, Yan-yan Pan, Zhi-fei Cao, Zhi-qing Zhang, Quan-sheng Zhou, Bo Yang, Cong Cao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of genes regulating migration and invasion using a new model of metastatic prostate cancer

Jacqueline Banyard, Ivy Chung, Matthew Migliozzi, Derek T Phan, Arianne M Wilson, Bruce R Zetter, Diane R Bielenberg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

What do women with gynecologic cancer know about HPV and their individual disease? A pilot study

Sophie Pils, Elmar A Joura, Max-Paul Winter, Anup Shrestha, Agnes Jaeger-Lansky, Johannes Ott

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Bimodal mortality dynamics for uveal melanoma: a cue for metastasis development traits?

Romano Demicheli, Marco Fornili, Elia Biganzoli

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Leptomeningeal metastasis from hepatocellular carcinoma with other unusual metastases: a case report

Zhenyu Pan, Guozi Yang, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Limei Qu, Lihua Dong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cell proliferation and apoptosis in rat mammary glands following combinational exposure to bisphenol A and genistein

Jun Wang, Sarah Jenkins, Coral A Lamartiniere

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The development and validation of oral cancer staging using administrative health data

Chang Li-Ting, Chen Chung-Ho, Yang Yi-Hsin, Ho Pei-Shan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differential expression patterns and clinical significance of estrogen receptor-α and β in papillary thyroid carcinoma

Yanhong Huang, Wenwu Dong, Jing Li, Hao Zhang, Zhongyan Shan, Weiping Teng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of E-cadherin and β-catenin in basaloid and conventional squamous cell carcinoma of the oral cavity: are potential prognostic markers?

João Adolfo Costa Hanemann, Denise Tostes Oliveira, Suely Nonogaki, Inês Nobuko Nishimoto, Marina Lara de Carli, Gilles Landman, Luiz Paulo Kowalski

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Thrombomodulin expression regulates tumorigenesis in bladder cancer

Chun-Te Wu, Ying-Hsu Chang, Paul- Yang Lin, Wen-Cheng Chen, Miao-Fen Chen

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Correlating tumor metabolic progression index measured by serial FDG PET-CT, apparent diffusion coefficient measured by magnetic resonance imaging (MRI) and blood genomics to patient’s outcome in advanced colorectal cancer: the CORIOLAN study

Amelie Deleporte, Marianne Paesmans, Camilo Garcia, Caroline Vandeputte, Marc Lemort, Jean-Luc Engelholm, Frederic Hoerner, Philippe Aftimos, Ahmad Awada, Nicolas Charette, Godelieve Machiels, Martine Piccart, Patrick Flamen, Alain Hendlisz

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A combination of p300 and Braf expression in the diagnosis and prognosis of melanoma

Madhuri Bhandaru, Gholamreza Safaee Ardekani, Guohong Zhang, Magdalena Martinka, Kevin J McElwee, Gang Li, Anand Rotte

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinicopathologic features and prognostic implications of NOK/STYK1 protein expression in non-small cell lung cancer

Peng Chen, Wei-Miao Li, Qiang Lu, Jian Wang, Xiao-Long Yan, Zhi-Pei Zhang, Xiao-Fei Li

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Human Papillomavirus 16, 18, 31 and 45 viral load, integration and methylation status stratified by cervical disease stage

Luigi Marongiu, Anna Godi, John V Parry, Simon Beddows

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Perioperative rehabilitation in operation for lung cancer (PROLUCA) – rationale and design

Maja S Sommer, Karen Trier, Jette Vibe-Petersen, Malene Missel, Merete Christensen, Klaus R Larsen, Seppo W Langer, Carsten Hendriksen, Paul Clementsen, Jesper H Pedersen, Henning Langberg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The effects of conjugate and light dose on photo-immunotherapy induced cytotoxicity

Takahito Nakajima, Kazuhide Sato, Hirofumi Hanaoka, Rira Watanabe, Toshiko Harada, Peter L Choyke, Hisataka Kobayashi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients

Natalia Krawczyk, Andreas Hartkopf, Malgorzata Banys, Franziska Meier-Stiegen, Annette Staebler, Markus Wallwiener, Carmen Röhm, Juergen Hoffmann, Markus Hahn, Tanja Fehm

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Lipid metabolism enzyme ACSVL3 supports glioblastoma stem cell maintenance and tumorigenicity

Peng Sun, Shuli Xia, Bachchu Lal, Xiaohai Shi, Kil Sung Yang, Paul A Watkins, John Laterra

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Modeling optimal cervical cancer prevention strategies in Nigeria

Nadia Demarteau, Imran O Morhason-Bello, Babatunde Akinwunmi, Isaac F Adewole

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluation of the impact of transient interruption of antiangiogenic treatment using ultrasound-based techniques in a murine model of hepatocellular carcinoma

Sara Marinelli, Veronica Salvatore, Marco Baron Toaldo, Maddalena Milazzo, Luca Croci, Laura Venerandi, Anna Pecorelli, Chiara Palamà, Alessia Diana, Luigi Bolondi, Fabio Piscaglia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of prognostic factors and surgical indications for metastatic gastric cancer

Yasuhiko Mohri, Koji Tanaka, Masaki Ohi, Susumu Saigusa, Hiromi Yasuda, Yuji Toiyama, Toshimitu Araki, Yasuhiro Inoue, Masato Kusunoki

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Sequential neoadjuvant chemoradiotherapy (CRT) followed by curative surgery vs. primary surgery alone for resectable, non-metastasized pancreatic adenocarcinoma: NEOPA- a randomized multicenter phase III study (NCT01900327, DRKS00003893, ISRCTN82191749)

Michael Tachezy, Florian Gebauer, Cordula Petersen, Dirk Arnold, Martin Trepel, Karl Wegscheider, Phillipe Schafhausen, Maximilian Bockhorn, Jakob Robert Izbicki, Emre Yekebas

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Ji Wook Moon, Soo Kyung Lee, Yong Woo Lee, Jung Ok Lee, Nami Kim, Hye Jeong Lee, Jung Seon Seo, Jin Kim, Hyeon Soo Kim, Sun-Hwa Park

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan

Cheng-Chieh Lin, Jen-Huai Chiang, Chia-Ing Li, Chiu-Shong Liu, Wen-Yuan Lin, Teng-Fu Hsieh, Tsai-Chung Li

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Altered glutamyl-aminopeptidase activity and expression in renal neoplasms

Lorena Blanco, Begoña Sanz, Itxaro Perez, Clara E Sánchez, M Luz Cándenas, Francisco M Pinto, Javier Gil, Luis Casis, José I López, Gorka Larrinaga

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Adherence to hormone therapy among women with breast cancer

Claudia Brito, Margareth Crisóstomo Portela, Mauricio Teixeira Leite de Vasconcellos

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inaugural bone metastases in non-small cell lung cancer: a specific prognostic entity?

Mélanie Deberne, Stanislas Ropert, Bertrand Billemont, Catherine Daniel, Jeanne Chapron, François Goldwasser

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Changes in vitamin and mineral supplement use after breast cancer diagnosis in the Pathways Study: a prospective cohort study

Heather Greenlee, Marilyn L Kwan, Isaac J Ergas, Garrett Strizich, Janise M Roh, Allegra T Wilson, Marion Lee, Karen J Sherman, Christine B Ambrosone, Dawn L Hershman, Alfred I Neugut, Lawrence H Kushi

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities

Alberto L’Abbate, Crocifissa Lo Cunsolo, Ettore Macrì, Paolo Iuzzolino, Cristina Mecucci, Claudio Doglioni, Michelina Coco, Lucia Anna Muscarella, Simona Salati, Enrico Tagliafico, Carla Minoia, Giacoma De Tullio, Attilio Guarini, Nicoletta Testoni, Claudio Agostinelli, Clelia Tiziana Storlazzi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Carbonic anhydrase 9 is associated with chemosensitivity and prognosis in breast cancer patients treated with taxane and anthracycline

Naoki Aomatsu, Masakazu Yashiro, Shinichiro Kashiwagi, Hidemi Kawajiri, Tsutomu Takashima, Masahiko Ohsawa, Kenichi Wakasa, Kosei Hirakawa

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Recurrent differentiated thyroid cancer: towards personalized treatment based on evaluation of tumor characteristics with PET (THYROPET Study): study protocol of a multicenter observational cohort study

Jakob W Kist, Bart de Keizer, Marcel PM Stokkel, Otto S Hoekstra, Wouter V Vogel, THYROPET study group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Association of interferon regulatory factor 4 gene polymorphisms rs12203592 and rs872071 with skin cancer and haematological malignancies susceptibility: a meta-analysis of 19 case–control studies

Songtao Wang, Qing Yan, Pin Chen, Peng Zhao, Aihua Gu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix

Yue Ma, Jienan Kong, Guanghai Yan, Xiangshan Ren, Dan Jin, Tiefeng Jin, Lijuan Lin, Zhenhua Lin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increased health care utilization by survivors of childhood lymphoblastic leukemia is confined to those treated with cranial or total body irradiation: a case cohort study

Anna Sällfors Holmqvist, Christian Moëll, Lars Hjorth, Anna Lindgren, Stanislaw Garwicz, Thomas Wiebe, Ingrid Øra

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts

Zuzana Ditte, Peter Ditte, Martina Labudova, Veronika Simko, Filippo Iuliano, Miriam Zatovicova, Lucia Csaderova, Silvia Pastorekova, Jaromir Pastorek

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A germline mutation in the BRCA13’UTR predicts Stage IV breast cancer

Jemima J Dorairaj, David W Salzman, Deirdre Wall, Tiffany Rounds, Carina Preskill, Catherine AW Sullivan, Robert Lindner, Catherine Curran, Kim Lezon-Geyda, Terri McVeigh, Lyndsay Harris, John Newell, Michael J Kerin, Marie Wood, Nicola Miller, Joanne B Weidhaas

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Monitoring changes in circulating tumour cells as a prognostic indicator of overall survival and treatment response in patients with metastatic melanoma

Dragana Klinac, Elin S Gray, James B Freeman, Anna Reid, Samantha Bowyer, Michael Millward, Melanie Ziman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

14-3-3σ induces heat shock protein 70 expression in hepatocellular carcinoma

Chia-Chia Liu, Yee-Jee Jan, Bor-Sheng Ko, Yao-Ming Wu, Shu-Man Liang, Shyh-Chang Chen, Yen-Ming Lee, Tzu-An Liu, Tzu-Ching Chang, John Wang, Song-Kun Shyue, Li-Ying Sung, Jun-Yang Liou

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas

Maria Giulia Bacalini, Annalisa Pacilli, Cristina Giuliani, Marianna Penzo, Davide Treré, Chiara Pirazzini, Stefano Salvioli, Claudio Franceschi, Lorenzo Montanaro, Paolo Garagnani

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Survival analysis of patients with non-small cell lung cancer who underwent surgical resection following 4 lung cancer resection guidelines

Dongsheng Yue, Liqun Gong, Jian You, Yanjun Su, Zhenfa Zhang, Zhen Zhang, Feng Gu, Meng Wang, Changli Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer

Linna Su, Xiangqiang Liu, Na Chai, Lifen Lv, Rui Wang, Xiaosa Li, Yongzhan Nie, Yongquan Shi, Daiming Fan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-26b inhibits epithelial-mesenchymal transition in hepatocellular carcinoma by targeting USP9X

Gang Shen, Ye Lin, Xuewei Yang, Jing Zhang, Zhe Xu, Hongyun Jia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

COUP-TFI modifies CXCL12 and CXCR4 expression by activating EGF signaling and stimulates breast cancer cell migration

Antoine Boudot, Gwenneg Kerdivel, Sylvain Lecomte, Gilles Flouriot, Mireille Desille, Florence Godey, Jean Leveque, Patrick Tas, Yves Le Dréan, Farzad Pakdel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Mohammad Sorowar Hossain, Mohd S Iqbal, Mohiuddin Ahmed Khan, Mohammad Golam Rabbani, Hazera Khatun, Sirajam Munira, M Morshed Zaman Miah, Amin Lutful Kabir, Naima Islam, Tashmim Farhana Dipta, Farzana Rahman, Abdul Mottalib, Salma Afrose, Tasneem Ara, Akhil Ranjan Biswas, Mizanur Rahman, AKM Mustafa Abedin, Mahbubur Rahman, ABM Yunus, Louis W Niessen, Tanvira Afroze Sultana

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Aspirin intake and breast cancer survival – a nation-wide study using prospectively recorded data in Sweden

Michelle D Holmes, Henrik Olsson, Yudi Pawitan, Johanna Holm, Cecilia Lundholm, Therese M-L Andersson, Hans-Olov Adami, Johan Askling, Karin Ekström Smedby

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Volumetric FDG-PET predicts overall and progression- free survival after 14 days of targeted therapy in metastatic renal cell carcinoma

Jacob Farnebo, Per Grybäck, Ulrika Harmenberg, Anna Laurell, Peter Wersäll, Lennart K Blomqvist, Anders Ullén, Per Sandström

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The transcriptional responsiveness of LKB1 to STAT-mediated signaling is differentially modulated by prolactin in human breast cancer cells

Katja Linher-Melville, Gurmit Singh

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea

Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The early response of renal cell carcinoma to tyrosine kinase inhibitors evaluated by FDG PET/CT was not influenced by metastatic organ

Manabu Kakizoe, Masahiro Yao, Ukihide Tateishi, Ryogo Minamimoto, Daiki Ueno, Kazuhiro Namura, Kazuhide Makiyama, Narihiko Hayashi, Futoshi Sano, Takeshi Kishida, Kazuki Kobayashi, Sumio Noguchi, Ichiro Ikeda, Yoshiharu Ohgo, Masataka Taguri, Satoshi Morita, Tomio Inoue, Yoshinobu Kubota, Noboru Nakaigawa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells

Qiang Wu, Xue Liu, Hong Yan, Yin-huan He, Shan Ye, Xing-wang Cheng, Gui-lu Zhu, Wen-yong Wu, Xiao-nan Wang, Xiang-jun Kong, Xiao-chun Xu, Peter E Lobie, Tao Zhu, Zheng-sheng Wu

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Steps toward improving diet and exercise for cancer survivors (STRIDE): a quasi-randomised controlled trial protocol

Lauren J Frensham, Dorota M Zarnowiecki, Gaynor Parfitt, Rebecca M Stanley, James Dollman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA response to hypoxic stress in soft tissue sarcoma cells: microRNA mediated regulation of HIF3α

Caroline MM Gits, Patricia F van Kuijk, Jonneke CWM de Rijck, Nikky Muskens, Moniek BE Jonkers, Wilfred F van IJcken, Ron HJ Mathijssen, Jaap Verweij, Stefan Sleijfer, Erik AC Wiemer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells

Ingvild J Brusevold, Ingun H Tveteraas, Monica Aasrum, John Ødegård, Dagny L Sandnes, Thoralf Christoffersen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis

Hsueh-Chun Wang, Wei-Fan Chiang, Hsin-Hsiu Huang, Ying-Ying Shen, Hung-Che Chiang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Human papillomavirus detection in women with and without human immunodeficiency virus infection in Colombia

Milena Camargo, Sara C Soto-De Leon, Marina Munoz, Ricardo Sanchez, Diego Peña-Herrera, Andrea Clemencia Pineda-Peña, Otto Sussmann, Carol Paez, Antonio Perez-Prados, Manuel Elkin Patarroyo, Manuel Alfonso Patarroyo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Solitary lymph node metastasis is a distinct subset of colon cancer associated with good survival: a retrospective study of surveillance, epidemiology, and end-results population-based data

Qingguo Li, Yuwei Wang, Guoxiang Cai, Dawei Li, Sanjun Cai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Down-regulation of the expression of CCAAT/enhancer binding protein α gene in cervical squamous cell carcinoma

Zemin Pan, Weinan Zheng, Jinli Zhang, Rui Gao, Dongmei Li, Xiaoqing Guo, Hu Han, Feng Li, Shen Qu, Renfu Shao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Celecoxib increases miR-222 while deterring aromatase-expressing breast tumor growth in mice

Tsz Yan Wong, Fengjuan Li, Shu-mei Lin, Franky L Chan, Shiuan Chen, Lai K Leung

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis

Ying Liu, Dong-lai Lv, Jiang-jie Duan, Sen-lin Xu, Jing-fang Zhang, Xiao-jun Yang, Xia Zhang, You-hong Cui, Xiu-wu Bian, Shi-cang Yu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Single cell mutational analysis of PIK3CA in circulating tumor cells and metastases in breast cancer reveals heterogeneity, discordance, and mutation persistence in cultured disseminated tumor cells from bone marrow

Glenn Deng, Sujatha Krishnakumar, Ashley A Powell, Haiyu Zhang, Michael N Mindrinos, Melinda L Telli, Ronald W Davis, Stefanie S Jeffrey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Overexpression of prostate tumor overexpressed 1 correlates with tumor progression and predicts poor prognosis in breast cancer

Fangyong Lei, Longjuan Zhang, Xinghua Li, Xi Lin, Shu Wu, Fengyan Li, Junling Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer

Anshu Aggarwal, Rami N Al-Rohil, Anupam Batra, Paul J Feustel, David M Jones, C Michael DiPersio

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim

Hye-Kyung Park, Ji-Eun Lee, Jaehwa Lim, Da-Eun Jo, Soo-Ah Park, Pann-Ghill Suh, Byoung Heon Kang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tyrosine phosphorylation profiling via in situproximity ligation assay

Lioudmila Elfineh, Christina Classon, Anna Asplund, Ulf Pettersson, Masood Kamali-Moghaddam, Sara Bergström Lind

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells

Bing Chen, Yuling Liu, Xuewen Jin, Weiliang Lu, Jingjing Liu, Zijing Xia, Qiong Yuan, Xia Zhao, Ningzhi Xu, Shufang Liang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Characteristics, survival, and related factors of newly diagnosed colorectal cancer patients refusing cancer treatments under a universal health insurance program

Chun-Yi Liu, William Tzu-Liang Chen, Pei-Tseng Kung, Chang-Fang Chiu, Yueh-Hsin Wang, Shwn-Huey Shieh, Wen-Chen Tsai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-205 inhibits cell apoptosis by targeting phosphatase and tensin homolog deleted on chromosome ten in endometrial cancer ishikawa cells

Guiyu Zhang, Xinxin Hou, Yue Li, Meng Zhao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The genetic basis for inactivation of Wnt pathway in human osteosarcoma

Xiaoling Du, Jilong Yang, Da Yang, Wei Tian, Ze Zhu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway

Pengfei Shi, Tao Yin, Feng Zhou, Pengfei Cui, Shanmiao Gou, Chunyou Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Changes in the transcriptional profile in response to overexpression of the osteopontin-c splice isoform in ovarian (OvCar-3) and prostate (PC-3) cancer cell lines

Tatiana M Tilli, Akeila Bellahcène, Vincent Castronovo, Etel R P Gimba

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity

Hongzhuan Yin, Jun Fang, Long Liao, Hiroshi Maeda, Qi Su

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

FOLFOX as second-line chemotherapy in patients with pretreated metastatic pancreatic cancer from the FIRGEM study

Aziz Zaanan, Isabelle Trouilloud, Theofano Markoutsaki, Mélanie Gauthier, Anne-Claire Dupont-Gossart, Thierry Lecomte, Thomas Aparicio, Pascal Artru, Anne Thirot-Bidault, Fanny Joubert, Daniella Fanica, Julien Taieb

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Oncogenic MicroRNAs: miR-155, miR-19a, miR-181b, and miR-24 enable monitoring of early breast cancer in serum

Marek Sochor, Petra Basova, Michal Pesta, Nina Dusilkova, Jiri Bartos, Pavel Burda, Vit Pospisil, Tomas Stopka

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model

Eleonora Vannini, Anna Panighini, Chiara Cerri, Alessia Fabbri, Simonetta Lisi, Enrico Pracucci, Nicola Benedetto, Riccardo Vannozzi, Carla Fiorentini, Matteo Caleo, Mario Costa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution 18F-FDG-directed surgery experience: feasibility and quantification of 18F-FDG accumulation within 18F-FDG-avid lesions and background tissues

Stephen P Povoski, Douglas A Murrey Jr, Sabrina M Smith, Edward W Martin Jr, Nathan C Hall

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Establishment of a novel clear cell sarcoma cell line (Hewga-CCS), and investigation of the antitumor effects of pazopanib on Hewga-CCS

Hidetatsu Outani, Takaaki Tanaka, Toru Wakamatsu, Yoshinori Imura, Kenichiro Hamada, Nobuhito Araki, Kazuyuki Itoh, Hideki Yoshikawa, Norifumi Naka

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancer

Jianli Wang, Siqin Ma, Rong Ma, Xun Qu, Wenjun Liu, Cuixia Lv, Song Zhao, Yunyun Gong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Real-time polymerase chain reaction analysis of MDM2 and CDK4expression using total RNA from core-needle biopsies is useful for diagnosing adipocytic tumors

Taro Sasaki, Akira Ogose, Hiroyuki Kawashima, Tetsuo Hotta, Hiroshi Hatano, Takashi Ariizumi, Hajime Umezu, Riuko Ohashi, Tsuyoshi Tohyama, Naohito Tanabe, Naoto Endo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Causes of death in patients with extranodal cancer of unknown primary: searching for the primary site

Matias Riihimäki, Akseli Hemminki, Kristina Sundquist, Kari Hemminki

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model

Anna Zajakina, Jelena Vasilevska, Dmitry Zhulenkovs, Dace Skrastina, Artjoms Spaks, Aiva Plotniece, Tatjana Kozlovska

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Bortezomib and dexamethasone for multiple myeloma: higher AST and LDH levels associated with a worse prognosis on overall survival

Takayoshi Kiba, Takuo Ito, Toshihisa Nakashima, Yoshiko Okikawa, Miki Kido, Akiko Kimura, Keita Kameda, Fumiaki Miyamae, Suzuko Tanaka, Misao Atsumi, Yoko Sumitani, Yoshimi Shitakubo, Hiromasa Niimi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

FHL1C induces apoptosis in notch1-dependent T-ALL cells through an interaction with RBP-J

Wei Fu, Kai Wang, Jun-Long Zhao, Heng-Chao Yu, San-Zhong Li, Yan Lin, Liang Liang, Si-Yong Huang, Ying-Min Liang, Hua Han, Hong-Yan Qin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Outcomes after stereotactic body radiotherapy for lung tumors, with emphasis on comparison of primary lung cancer and metastatic lung tumors

Takaya Yamamoto, Keiichi Jingu, Yuko Shirata, Masashi Koto, Haruo Matsushita, Toshiyuki Sugawara, Masaki Kubozono, Rei Umezawa, Keiko Abe, Noriyuki Kadoya, Youjirou Ishikawa, Maiko Kozumi, Noriyoshi Takahashi, Ken Takeda, Yoshihiro Takai

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The JACS prospective cohort study of newly diagnosed women with breast cancer investigating joint and muscle pain, aches, and stiffness: pain and quality of life after primary surgery and before adjuvant treatment

Deborah Fenlon, Cassandra Powers, Peter Simmonds, Joanne Clough, Julia Addington-Hall

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells

Hideyuki Abe, Takao Kamai, Keitaro Hayashi, Naohiko Anzai, Hiromichi Shirataki, Tomoya Mizuno, Yoshiyuki Yamaguchi, Akinori Masuda, Hideo Yuki, Hironori Betsunoh, Masahiro Yashi, Yoshitatsu Fukabori, Ken-Ichiro Yoshida

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Impact of comprehensive geriatric assessment on survival, function, and nutritional status in elderly patients with head and neck cancer: protocol for a multicentre randomised controlled trial (EGeSOR)

Lydia Brugel, Marie Laurent, Philippe Caillet, Anne Radenne, Isabelle Durand-Zaleski, Michel Martin, Melany Baron, Héloïse de Kermadec, Sylvie Bastuji-Garin, Florence Canouï-Poitrine, Elena Paillaud

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer

Zuzana Cierna, Michal Mego, Pavol Janega, Marian Karaba, Gabriel Minarik, Juraj Benca, Tatiana Sedlácková, Silvia Cingelova, Paulina Gronesova, Denisa Manasova, Daniel Pindak, Jozef Sufliarsky, Ludovit Danihel, James M Reuben, Jozef Mardiak

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Rationale and design of LUX-Head & Neck 1: a randomised, Phase III trial of afatinib versus methotrexate in patients with recurrent and/or metastatic head and neck squamous cell carcinoma who progressed after platinum-based therapy

Jean-Pascal H Machiels, Lisa F Licitra, Robert I Haddad, Makoto Tahara, Ezra EW Cohen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A grey literature review of special events for promoting cancer screenings

Cam Escoffery, Kirsten C Rodgers, Michelle C Kegler, Mary Ayala, Erika Pinsker, Regine Haardörfer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Animal model of naturally occurring bladder cancer: Characterization of four new canine transitional cell carcinoma cell lines

Kusum Rathore, Maria Cekanova

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inhibitory effects of prostaglandin E2on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma

Ewa Pomianowska, Dagny Sandnes, Krzysztof Grzyb, Aasa R Schjølberg, Monica Aasrum, Ingun H Tveteraas, Vegard Tjomsland, Thoralf Christoffersen, Ivar P Gladhaug

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Family-specific, novel, deleterious germline variants provide a rich resource to identify genetic predispositions for BRCAx familial breast cancer

Hongxiu Wen, Yeong C Kim, Carrie Snyder, Fengxia Xiao, Elizabeth A Fleissner, Dina Becirovic, Jiangtao Luo, Bradley Downs, Simon Sherman, Kenneth H Cowan, Henry T Lynch, San Ming Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Time trends in socioeconomic inequalities in cancer mortality: results from a 35 year prospective study in British men

Sheena E Ramsay, Richard W Morris, Peter H Whincup, Anna Olia Papacosta, Lucy T Lennon, Sasiwarang Goya Wannamethee

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Functional deficiency of NBN, the Nijmegen breakage syndrome protein, in a p.R215W mutant breast cancer cell line

Bianca Schröder-Heurich, Natalia Bogdanova, Britta Wieland, Xiaoxi Xie, Monika Noskowicz, Tjoung-Won Park-Simon, Peter Hillemanns, Hans Christiansen, Thilo Dörk

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

IL-1β mediates MCP-1 induction by Wnt5a in gastric cancer cells

Shengjun Li, Wei Wang, Ning Zhang, Tingxian Ma, Chenghai Zhao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Oncogenic Fli-1 is a potential prognostic marker for the progression of epithelial ovarian cancer

Wei Song, Lingyun Hu, Wei Li, Guanjun Wang, Yan Li, Lei Yan, Ailing Li, Jiuwei Cui

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Colon and rectal cancer incidence and water trihalomethane concentrations in New South Wales, Australia

Md Bayzidur Rahman, Christine Cowie, Tim Driscoll, Richard J Summerhayes, Bruce K Armstrong, Mark S Clements

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Solitary breast metastasis from myxoid liposarcoma

Masahiro Yokouchi, Satoshi Nagano, Yuko Kijima, Takako Yoshioka, Akihide Tanimoto, Shoji Natsugoe, Setsuro Komiya

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

TIMP-1 and responsiveness to gemcitabine in advanced breast cancer; results from a randomized phase III trial from the Danish breast cancer cooperative group

Charlotte Levin Tykjær Jørgensen, Christina Bjerre, Bent Ejlertsen, Karsten D Bjerre, Eva Balslev, Annette Bartels, Nils Brünner, Dorte L Nielsen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea

Sohee Park, Sun Ha Jee, Hai-Rim Shin, Eun Hye Park, Aesun Shin, Kyu-Won Jung, Seung-Sik Hwang, Eun Shil Cha, Young Ho Yun, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Little evidence for association between the TGFBR1*6A variant and colorectal cancer: a family-based association study on non-syndromic family members from Australia and Spain

Jason P Ross, Linda J Lockett, Bruce Tabor, Ian W Saunders, Graeme P Young, Finlay Macrae, Ignacio Blanco, Gabriel Capella, Glenn S Brown, Trevor J Lockett, Garry N Hannan

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer

Gianluca Tedaldi, Rita Danesi, Valentina Zampiga, Michela Tebaldi, Lucia Bedei, Wainer Zoli, Dino Amadori, Fabio Falcini, Daniele Calistri

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Circulating anti-filamin C autoantibody as a potential serum biomarker for low-grade gliomas

Masayo Adachi-Hayama, Akihiko Adachi, Natsuki Shinozaki, Tomoo Matsutani, Takaki Hiwasa, Masaki Takiguchi, Naokatsu Saeki, Yasuo Iwadate

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

RITA (Reactivating p53 and Inducing Tumor Apoptosis) is efficient against TP53 abnormal myeloma cells independently of the p53 pathway

Sylvanie Surget, Géraldine Descamps, Carole Brosseau, Vincent Normant, Sophie Maïga, Patricia Gomez-Bougie, Nadège Gouy-Colin, Catherine Godon, Marie C Béné, Philippe Moreau, Steven Le Gouill, Martine Amiot, Catherine Pellat-Deceunynck

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Association between the TP53 codon 72 polymorphism and risk of oral squamous cell carcinoma in Asians: a meta-analysis

Xian-Tao Zeng, Wei Luo, Pei-Liang Geng, Yi Guo, Yu-Ming Niu, Wei-Dong Leng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

VEGFR-3 and CXCR4 as predictive markers for treatment with fluorouracil, leucovorin plus either oxaliplatin or cisplatin in patients with advanced esophagogastric cancer: a comparative study of the Arbeitsgemeinschaft Internistische Onkologie (AIO)

Thomas Thomaidis, Annett Maderer, Salah-Eddin Al-Batran, Janis Kany, Claudia Pauligk, Kristina Steinmetz, Arno Schad, Ralf Hofheinz, Harald Schmalenberg, Nils Homann, Peter Robert Galle, Markus Moehler

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Docosahexaenoic acid-induced apoptosis is mediated by activation of mitogen-activated protein kinases in human cancer cells

Soyeon Jeong, Kaipeng Jing, Nayeong Kim, Soyeon Shin, Soyeon Kim, Kyoung-Sub Song, Jun-Young Heo, Ji-Hoon Park, Kang-Sik Seo, Jeongsu Han, Tong Wu, Gi-Ryang Kweon, Seung-Kiel Park, Jong-Il Park, Kyu Lim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

γH2AX and Chk1 phosphorylation as predictive pharmacodynamic biomarkers of Chk1 inhibitor-chemotherapy combination treatments

Rebecca Rawlinson, Andrew J Massey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pain response of resistance training of the paravertebral musculature under radiotherapy in patients with spinal bone metastases – a randomized trial

Harald Rief, Thomas Welzel, Georg Omlor, Michael Akbar, Thomas Bruckner, Stefan Rieken, Matthias F Haefner, Ingmar Schlampp, Alexandros Gioules, Jürgen Debus

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study

Marlies S Reimers, Charla C Engels, Hein Putter, Hans Morreau, Gerrit Jan Liefers, Cornelis JH van de Velde, Peter JK Kuppen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Establishment of using serum YKL-40 and SCCA in combination for the diagnosis of patients with esophageal squamous cell carcinoma

Xin Zheng, Shan Xing, Xiao-Min Liu, Wen Liu, Dan Liu, Pei-Dong Chi, Hao Chen, Shu-Qin Dai, Qian Zhong, Mu-Sheng Zeng, Wan-Li Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

An effective and well-tolerated strategy in recurrent and/or metastatic head and neck cancer: successive lines of active chemotherapeutic agents

Julien Péron, Valentine Polivka, Sylvie Chabaud, Marc Poupart, Philippe Ceruse, Antoine Ramade, Didier Girodet, Philippe Zrounba, Jérôme Fayette

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

CT based three dimensional dose-volume evaluations for high-dose rate intracavitary brachytherapy for cervical cancer

Naoya Murakami, Takahiro Kasamatsu, Akihisa Wakita, Satoshi Nakamura, Hiroyoki Okamoto, Koji Inaba, Madoka Morota, Yoshinori Ito, Minako Sumi, Jun Itami

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

DNA methylation alterations of AXIN2 in serrated adenomas and colon carcinomas with microsatellite instability

Yuta Muto, Takafumi Maeda, Koichi Suzuki, Takaharu Kato, Fumiaki Watanabe, Hidenori Kamiyama, Masaaki Saito, Kei Koizumi, Yuichiro Miyaki, Fumio Konishi, Sergio Alonso, Manuel Perucho, Toshiki Rikiyama

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis

Gillian K Gresham, George A Wells, Sharlene Gill, Christopher Cameron, Derek J Jonker

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Myofibroblastic stromal reaction and lymph node status in invasive breast carcinoma: possible role of the TGF-β1/TGF-βR1 pathway

Xavier Catteau, Philippe Simon, Jean-Christophe Noël

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Special role of Foxp3 for the specifically altered microRNAs in Regulatory T cells of HCC patients

Long Chen, Huiying Ma, Heng Hu, Lingling Gao, Xuan Wang, Jiaqi Ma, Qiang Gao, Binbin Liu, Guomin Zhou, Chunmin Liang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Selection criteria for radiofrequency ablation for colorectal liver metastases in the era of effective systemic therapy: a clinical score based proposal

Axel Stang, Karl Jürgen Oldhafer, Hauke Weilert, Handan Keles, Marcello Donati

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone

Burkhard Lehner, Pierre Kunz, Heiner Saehr, Joerg Fellenberg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Estimation of savings of life-years and cost from early detection of cervical cancer: a follow-up study using nationwide databases for the period 2002–2009

Mei-Chuan Hung, Meng-Ting Liu, Ya-Min Cheng, Jung-Der Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis

Klaus Mross, Martin Büchert, Annette Frost, Michael Medinger, Peter Stopfer, Matus Studeny, Rolf Kaiser

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A comparative study of two PODXL antibodies in 840 colorectal cancer patients

Tuomas Kaprio, Jaana Hagström, Christian Fermér, Harri Mustonen, Camilla Böckelman, Olle Nilsson, Caj Haglund

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The clinicopathological significance of neurogenesis in breast cancer

Qianqian Zhao, Yan Yang, Xizi Liang, Guangye Du, Liwei Liu, Lingjuan Lu, Junbo Dong, Hongxiu Han, Guohua Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A cross-sectional study of global DNA methylation and risk of colorectal adenoma

Will D King, Janet E Ashbury, Sherryl A Taylor, M Yat Tse, Stephen C Pang, Jacob A Louw, Stephen J Vanner

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Radiation dose and survival of patients with stage IV non-small cell lung cancer undergoing concurrent chemotherapy and thoracic three-dimensional radiotherapy: reanalysis of the findings of a single-center prospective study

Wei-Wei Ouyang, Sheng-Fa Su, Yin-Xiang Hu, Bing Lu, Zhu Ma, Qing-Song Li, Hui-Qin Li, Yi-Chao Geng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Helicase-like transcription factor: a new marker of well-differentiated thyroid cancers

Vanessa Arcolia, Paula Paci, Ludovic Dhont, Gilbert Chantrain, Nicolas Sirtaine, Christine Decaestecker, Myriam Remmelink, Alexandra Belayew, Sven Saussez

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Understanding what matters most to people with multiple myeloma: a qualitative study of views on quality of life

Thomas R Osborne, Christina Ramsenthaler, Susanne de Wolf-Linder, Stephen A Schey, Richard J Siegert, Polly M Edmonds, Irene J Higginson

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

FOXFIRE protocol: an open-label, randomised, phase III trial of 5-fluorouracil, oxaliplatin and folinic acid (OxMdG) with or without interventional Selective Internal Radiation Therapy (SIRT) as first-line treatment for patients with unresectable liver-only or liver-dominant metastatic colorectal cancer

Susan J Dutton, Nicola Kenealy, Sharon B Love, Harpreet S Wasan, Ricky A Sharma

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis

Un-Ho Jin, Syng-Ook Lee, Catherine Pfent, Stephen Safe

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC)

Ju Yang, Huanlei Wu, Sheng Wei, Huihua Xiong, Xiangning Fu, Zhaozhen Qi, Qian Jiang, Wen Li, Guangyuan Hu, Xianglin Yuan, Zhongxing Liao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increase of gap junction activities in SW480 human colorectal cancer cells

Kristina Bigelow, Thu A Nguyen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas

Victoria K Hill, Thoraia Shinawi, Christopher J Ricketts, Dietmar Krex, Gabriele Schackert, Julien Bauer, Wenbin Wei, Garth Cruickshank, Eamonn R Maher, Farida Latif

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells

Luis A Aparicio, Raquel Castosa, Mar Haz-Conde, Marta Rodríguez, Moisés Blanco, Manuel Valladares, Angélica Figueroa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pemetrexed for advanced non-small cell lung cancer patients with interstitial lung disease

Motoyasu Kato, Takehito Shukuya, Fumiyuki Takahashi, Keita Mori, Kentaro Suina, Tetsuhiko Asao, Ryota Kanemaru, Yuichiro Honma, Keiko Muraki, Koji Sugano, Rina Shibayama, Ryo Koyama, Naoko Shimada, Kazuhisa Takahashi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic impact of MGMT promoter methylation and MGMT and CD133 expression in colorectal adenocarcinoma

Jaime Antonio Oliver, Raúl Ortiz, Consolación Melguizo, Pablo Juan Álvarez, Jaime Gómez-Millán, Jose Prados

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients

Markus Wallwiener, Sabine Riethdorf, Andreas Daniel Hartkopf, Caroline Modugno, Juliane Nees, Dharanija Madhavan, Martin Ronald Sprick, Sarah Schott, Christoph Domschke, Irène Baccelli, Birgitt Schönfisch, Barbara Burwinkel, Frederik Marmé, Jörg Heil, Christof Sohn, Klaus Pantel, Andreas Trumpp, Andreas Schneeweiss

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The electronic self report assessment and intervention for cancer: promoting patient verbal reporting of symptom and quality of life issues in a randomized controlled trial

Donna L Berry, Fangxin Hong, Barbara Halpenny, Anne Partridge, Erica Fox, Jesse R Fann, Seth Wolpin, William B Lober, Nigel Bush, Upendra Parvathaneni, Dagmar Amtmann, Rosemary Ford

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Comparison of molecular and immunocytochemical methods for detection of disseminated tumor cells in bone marrow from early breast cancer patients

Bjørnar Gilje, Oddmund Nordgård, Kjersti Tjensvoll, Elin Borgen, Marit Synnestvedt, Rune Smaaland, Bjørn Naume

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Podocalyxin is a marker of poor prognosis in colorectal cancer

Tuomas Kaprio, Christian Fermér, Jaana Hagström, Harri Mustonen, Camilla Böckelman, Olle Nilsson, Caj Haglund

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model

Séverine Roselli, Richard GS Kahl, Ben T Copeland, Matthew J Naylor, Judith Weidenhofer, William J Muller, Leonie K Ashman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial

George Fountzilas, Urania Dafni, Christos Papadimitriou, Eleni Timotheadou, Helen Gogas, Anastasia G Eleftheraki, Ioannis Xanthakis, Christos Christodoulou, Angelos Koutras, Christos N Papandreou, Pavlos Papakostas, Spyros Miliaras, Christos Markopoulos, Constantine Dimitrakakis, Panagiotis Korantzopoulos, Charisios Karanikiotis, Dimitrios Bafaloukos, Paris Kosmidis, Epaminontas Samantas, Ioannis Varthalitis, Nicholas Pavlidis, Dimitrios Pectasides, Meletios-Athanassios Dimopoulos

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of astrocyte elevated gene-1 (AEG-1) as a biomarker for aggressive pancreatic ductal adenocarcinoma

Yan Huang, Guo-Ping Ren, Chao Xu, Shui-Feng Dong, Ying Wang, Yun Gan, Li Zhu, Tian-Yuan Feng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Suppression of the epithelial-mesenchymal transition by SHARP1 is linked to the NOTCH1 signaling pathway in metastasis of endometrial cancer

Yun Liao, Xiaoying He, Haifeng Qiu, Qi Che, Fangyuan Wang, Wen Lu, Zheng Chen, Meiting Qiu, Jingyun Wang, Huihui Wang, Xiaoping Wan

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

GNAQmutation in a patient with metastatic mucosal melanoma

Chung-Young Kim, Dae Won Kim, Kevin Kim, Jonathan Curry, Carlos Torres-Cabala, Sapna Patel

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The size of the primary tumor and age at initial diagnosis are independent predictors of the metastatic behavior and survival of patients with SDHB-related pheochromocytoma and paraganglioma: a retrospective cohort study

Jan Schovanek, Victoria Martucci, Robert Wesley, Tito Fojo, Jaydira del Rivero, Thanh Huynh, Karen Adams, Electron Kebebew, Zdenek Frysak, Constantine A Stratakis, Karel Pacak

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Minichromosome Maintenance (MCM) Family as potential diagnostic and prognostic tumor markers for human gliomas

Cong Hua, Gang Zhao, Yunqian Li, Li Bie

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Personalized prostate cancer screening among men with high risk genetic predisposition- study protocol for a prospective cohort study

David Margel, Ofer Benjaminov, Rachel Ozalvo, Liat Shavit Grievink, Inbal Kedar, Rinat Yerushalmi, Irit Ben-Aharon, Victoria Neiman, Ofer Yossepowitch, Daniel Kedar, Zohar Levy, Mordechai Shohat, Baruch Brenner, Jack Baniel, Eli Rosenbaum

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib

Noriyuki Koyama, Kenichi Saito, Yuki Nishioka, Wataru Yusa, Noboru Yamamoto, Yasuhide Yamada, Hiroshi Nokihara, Fumiaki Koizumi, Kazuto Nishio, Tomohide Tamura

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

Anne Benard, Inès J Goossens-Beumer, Anneke Q van Hoesel, Wouter de Graaf, Hamed Horati, Hein Putter, Eliane CM Zeestraten, Cornelis JH van de Velde, Peter JK Kuppen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Serum tryptase, mast cells positive to tryptase and microvascular density evaluation in early breast cancer patients: possible translational significance

Ilaria Marech, Michele Ammendola, Rosario Sacco, Gennaro Stefano Capriuolo, Rosa Patruno, Rosangela Rubini, Maria Luposella, Valeria Zuccalà, Eufemia Savino, Cosmo Damiano Gadaleta, Domenico Ribatti, Girolamo Ranieri

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Dose escalating study of cetuximab and 5-FU/folinic acid (FA)/oxaliplatin/irinotecan (FOLFOXIRI) in first line therapy of patients with metastatic colorectal cancer

Gunnar Folprecht, Susanne Hamann, Katharina Schütte, Tanja Trarbach, Jan Stoehlmacher-Williams, Gerhard Ehninger

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Low levels of 3,3′-diindolylmethane activate estrogen receptor α and induce proliferation of breast cancer cells in the absence of estradiol

Maud Marques, Liette Laflamme, Ines Benassou, Coumba Cissokho, Benoit Guillemette, Luc Gaudreau

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Copper chelation selectively kills colon cancer cells through redox cycling and generation of reactive oxygen species

Maamoun Fatfat, Raghida Abou Merhi, Omar Rahal, Detcho A Stoyanovsky, Angela Zaki, Hazar Haidar, Valerian E Kagan, Hala Gali-Muhtasib, Khaled Machaca

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA profile in very young women with breast cancer

Maria Peña-Chilet, Maria T Martínez, Jose A Pérez-Fidalgo, Lorena Peiró-Chova, Sara S Oltra, Eduardo Tormo, Elisa Alonso-Yuste, Beatriz Martinez-Delgado, Pilar Eroles, Joan Climent, Octavio Burgués, Jaime Ferrer-Lozano, Ana Bosch, Ana Lluch, Gloria Ribas

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis

Ewa Pomianowska, Aasa R Schjølberg, Ole Petter F Clausen, Ivar P Gladhaug

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells

Wen-feng Gou, Yang Zhao, Hang Lu, Xue-feng Yang, Yin-ling Xiu, Shuang Zhao, Jian-min Liu, Zhi-tu Zhu, Hong-zhi Sun, Yun-peng Liu, Feng Xu, Yasuo Takano, Hua-chuan Zheng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BiOsimilaRs in the management of anaemia secondary to chemotherapy in HaEmatology and Oncology: results of the ORHEO observational study

Mauricette Michallet, Elisabeth Luporsi, Pierre Soubeyran, Nadia Ali Amar, Vincent Boulanger, Miguel Carreiro, Louis-Marie Dourthe, Jean-Luc Labourey, Daniel Lepille, Frédéric Maloisel, Jean-Loup Mouysset, Sophie Nahon, Bérengère Narciso, Pierre Nouyrigat, Raouf Radji, Nacéra Sakek, Hélène Albrand, The ORHEO study group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Promoting E2F1-mediated apoptosis in oestrogen receptor-α-negative breast cancer cells

María F Montenegro, María del Mar Collado-González, María Piedad Fernández-Pérez, Manel B Hammouda, Lana Tolordava, Mariam Gamkrelidze, José Neptuno Rodríguez-López

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cancer caregiving tasks and consequences and their associations with caregiver status and the caregiver’s relationship to the patient: a survey

Line Lund, Lone Ross, Morten Aagaard Petersen, Mogens Groenvold

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

A late, solitary brain metastasis of epithelial ovarian carcinoma

Raffaele Longo, Christian Platini, Nada Eid, Clémence Elias-Matta, Thaar Buda, Denis 'Nguyen, Philippe Quétin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes

Silvia Darb-Esfahani, Gunter von Minckwitz, Carsten Denkert, Beyhan Ataseven, Bernhard Högel, Keyur Mehta, Gabriele Kaltenecker, Thomas Rüdiger, Berit Pfitzner, Kornelia Kittel, Bettina Fiedler, Klaus Baumann, Roland Moll, Manfred Dietel, Holger Eidtmann, Christoph Thomssen, Sibylle Loibl

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Reduced drug incorporation into DNA and antiapoptosis as the crucial mechanisms of resistance in a novel nelarabine-resistant cell line

Takahiro Yamauchi, Kanako Uzui, Rie Nishi, Hiroko Shigemi, Takanori Ueda

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

An Activin A/BMP2 chimera, AB215, blocks estrogen signaling via induction of ID proteins in breast cancer cells

Jae Woo Jung, Sun Young Shim, Dong Kun Lee, Witek Kwiatkowski, Senyon Choe

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

A rare case of watery diarrhea, hypokalemia and achlorhydria syndrome caused by pheochromocytoma

Jingjing Jiang, Li Zhang, Zhaodi Wu, Zhilong Ai, Yingyong Hou, Zhiqiang Lu, Xin Gao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Whole-body total lesion glycolysis measured on fluorodeoxyglucose positron emission tomography/computed tomography as a prognostic variable in metastatic breast cancer

Yoko Satoh, Atsushi Nambu, Tomoaki Ichikawa, Hiroshi Onishi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Ionizing radiation induces tumor cell lysyl oxidase secretion

Colette J Shen, Ashish Sharma, Dinh-Van Vuong, Janine T Erler, Martin Pruschy, Angela Broggini-Tenzer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Hypoxia represses microRNA biogenesis proteins in breast cancer cells

Veronika Bandara, Michael Z Michael, Jonathan M Gleadle

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Time trends in municipal distribution patterns of cancer mortality in Spain

Gonzalo López-Abente, Nuria Aragonés, Beatriz Pérez-Gómez, Marina Pollán, Javier García-Pérez, Rebeca Ramis, Pablo Fernández-Navarro

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Irreversible electroporation of unresectable soft tissue tumors with vascular invasion: effective palliation

Robert CG Martin, Prejesh Philips, Susan Ellis, David Hayes, Sandeep Bagla

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Ki67 expression and the effect of neo-adjuvant chemotherapy on luminal HER2-negative breast cancer

Yoshiya Horimoto, Atsushi Arakawa, Masahiko Tanabe, Hiroshi Sonoue, Fumie Igari, Koji Senuma, Emi Tokuda, Hideo Shimizu, Taijiro Kosaka, Mitsue Saito

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver

Alexandra Naba, Karl R Clauser, Charles A Whittaker, Steven A Carr, Kenneth K Tanabe, Richard O Hynes

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Increased malignancy of oral squamous cell carcinomas (oscc) is associated with macrophage polarization in regional lymph nodes – an immunohistochemical study

Falk Wehrhan, Maike Büttner-Herold, Peter Hyckel, Patrick Moebius, Raimund Preidl, Luitpold Distel, Jutta Ries, Kerstin Amann, Christian Schmitt, Friedrich W Neukam, Manuel Weber

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells

Chandrani Achari, Sofia Winslow, Yvonne Ceder, Christer Larsson

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Identification of prognostic inflammatory factors in colorectal liver metastases

Trevor D Hamilton, Derek Leugner, Karen Kopciuk, Elijah Dixon, Francis R Sutherland, Oliver F Bathe

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Ectopic TSH-secreting pituitary tumor: a case report and review of prior cases

Mingqiang Song, Haijing Wang, Li Song, Haiye Tian, Quanxu Ge, Jun Li, Yan Zhu, Jizhou Li, Runzhen Zhao, Hong-Long Ji

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer

Hanbyoul Cho, Joon-Yong Chung, Kwon-Ho Song, Kyung Hee Noh, Bo Wook Kim, Eun Joo Chung, Kris Ylaya, Jin Hee Kim, Tae Woo Kim, Stephen M Hewitt, Jae-Hoon Kim

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

ΔNp63α enhances the oncogenic phenotype of osteosarcoma cells by inducing the expression of GLI2

Ram Mohan Ram Kumar, Michael M Betz, Bernhard Robl, Walter Born, Bruno Fuchs

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A phase I study of imatinib, dacarbazine, and capecitabine in advanced endocrine cancers

Daniel M Halperin, Alexandria T Phan, Ana O Hoff, Marie Aaron, James C Yao, Paulo M Hoff

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction

Eui Young So, Toru Ouchi

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic models to predict overall and cause-specific survival for patients with middle ear cancer: a population-based analysis

Weidong Shen, Naoko Sakamoto, Limin Yang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Glucose-regulated protein 58 modulates β-catenin protein stability in a cervical adenocarcinoma cell line

Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh, Kwang-Huei Lin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluation of the interval cancer rate and its determinants on the Girona health region’s early breast cancer detection program

Gemma Renart-Vicens, Montserrat Puig-Vives, Joan Albanell, Francesc Castañer, Joana Ferrer, Miquel Carreras, Joan Tarradas, Maria Sala, Rafael Marcos-Gragera

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Studying the impact of early life exposures to pesticides on the risk of testicular germ cell tumors during adulthood (TESTIS project): study protocol

Rémi Béranger, Olivia Pérol, Louis Bujan, Elodie Faure, Jeffrey Blain, Charlotte Le Cornet, Aude Flechon, Barbara Charbotel, Thierry Philip, Joachim Schüz, Béatrice Fervers

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

T3 levels in relation to prognostic factors in breast cancer: a population-based prospective cohort study

Ada Tosovic, Anne-Greth Bondeson, Lennart Bondeson, Ulla-Britt Ericsson, Jonas Manjer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

Augustine Chen, Henry Beetham, Michael A Black, Rashmi Priya, Bryony J Telford, Joanne Guest, George A R Wiggins, Tanis D Godwin, Alpha S Yap, Parry J Guilford

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Benzyl butyl phthalate induces migration, invasion, and angiogenesis of Huh7 hepatocellular carcinoma cells through nongenomic AhR/G-protein signaling

Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Feng-Jie Lai, Kung-Kai Kuo, Hua-Lin Wu, Eing-Mei Tsai, Po-Lin Kuo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

3'-Ethynylcytidine, an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

Hiroto Fukushima, Tetsuya Abe, Kazuki Sakamoto, Hiroaki Tsujimoto, Shinji Mizuarai, Shinji Oie

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Constitutive AKT activation in follicular lymphoma

Ouardia I Yahiaoui, Jacques A Nunès, Céline Castanier, Raynier Devillier, Florence Broussais, Aurélie J Fabre, Dalila Naimi, Réda Bouabdallah, Daniel Olive, Luc Xerri

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: a retrospective and in vitro study

Yi-Jun Shu, Hao Weng, Run-Fa Bao, Xiang-Song Wu, Qian Ding, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Mao-Lan Li, Jia-Sheng Mu, Wen-Guang Wu, Ying-Bin Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers

Yunshu Gao, Ying Chen, Dongyun Xu, Jiejun Wang, Guanzhen Yu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Macrophage inhibitory cytokine 1 (MIC-1/GDF15) as a novel diagnostic serum biomarker in pancreatic ductal adenocarcinoma

Xiaobing Wang, Yanfen Li, Haimei Tian, Jun Qi, Mo Li, Chao Fu, Fan Wu, Yi Wang, Dongwan Cheng, Wenya Zhao, Chao Zhang, Teng Wang, Jianyu Rao, Wei Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Detection of infectious organisms in archival prostate cancer tissues

Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Anthony Longano, Suzanne M Garland, Melissa C Southey, Graham G Giles

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer

Masafumi Horie, Akira Saito, Satoshi Noguchi, Yoko Yamaguchi, Mitsuhiro Ohshima, Yasuyuki Morishita, Hiroshi I Suzuki, Tadashi Kohyama, Takahide Nagase

01.12.2014 | Technical advance | Ausgabe 1/2014 Open Access

Comparative evaluation of the new FDA approved THxID™-BRAF test with high resolution melting and sanger sequencing

Julie Marchant, Alain Mange, Marion Larrieux, Valérie Costes, Jérôme Solassol

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluating the impact of public health initiatives on trends in fecal occult blood test participation in Ontario

Gladys N Honein-AbouHaidar, Linda Rabeneck, Lawrence F Paszat, Rinku Sutradhar, Jill Tinmouth, Nancy N Baxter

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Molecular subtyping of metastatic melanoma based on cell ganglioside metabolism profiles

Cristina Tringali, Ilaria Silvestri, Francesca Testa, Paola Baldassari, Luigi Anastasia, Roberta Mortarini, Andrea Anichini, Alejandro López-Requena, Guido Tettamanti, Bruno Venerando

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cardiac glycosides use and the risk of lung cancer: a nested case–control study

Sébastien Couraud, Laurent Azoulay, Sophie Dell’Aniello, Samy Suissa

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A novel naproxen derivative capable of displaying anti-cancer and anti-migratory properties against human breast cancer cells

Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya, Siddhartha Sankar Jana

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The clinical features and treatment modality of esophageal neuroendocrine tumors: a multicenter study in Korea

Chang Geun Lee, Yun Jeong Lim, Seun Ja Park, Byung Ik Jang, Seok Reyol Choi, Jae Kwang Kim, Yong-Tae Kim, Joo Young Cho, Chang Hun Yang, Hoon Jai Chun, Si Young Song, Neuroendocrine tumor study group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Overexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma

Luan-Jing Zhang, Ke-Bing Wang, Long-shan Liu, Lian-zhou Chen, Bao-Gang Peng, Li-Jian Liang, Zhi Li, Ling Xue, Wen Li, Jing-Tang Xia

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Effect of gastrointestinal resection on sunitinib exposure in patients with GIST

Djoeke de Wit, Nielka P van Erp, Reza Khosravan, Robin Wiltshire, Randy Allred, George D Demetri, Henk-Jan Guchelaar, Hans Gelderblom

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Regional and national guideline recommendations for digital ano-rectal examination as a means for anal cancer screening in HIV positive men who have sex with men: a systematic review

Jason J Ong, Marcus Chen, Andrew E Grulich, Christopher K Fairley

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Chk1 Inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers

Christopher Bryant, Rebecca Rawlinson, Andrew J Massey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Trimodal therapy for stage III-N2 non-small-cell lung carcinoma: a single center retrospective analysis

Vasileios Askoxylakis, Judith Tanner, Jutta Kappes, Hans Hoffmann, Nils H Nicolay, Harald Rief, Juergen Debus, Michael Thomas, Marc Bischof

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Protecting the underscreened women in developed countries: the value of HPV test

Raquel Ibáñez, Josefina Autonell, Montserrat Sardà, Nayade Crespo, Pilar Pique, Amparo Pascual, Clara Martí, Montserrat Fibla, Cristina Gutiérrez, Belén Lloveras, Judit Moreno-Crespi, Anna Torrent, Núria Baixeras, María Alejo, Francesc Xavier Bosch, Silvia de Sanjosé

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Polyploid giant cancer cells with budding and the expression of cyclin E, S-phase kinase-associated protein 2, stathmin associated with the grading and metastasis in serous ovarian tumor

Hongcheng Lv, Yang Shi, Li Zhang, Dan Zhang, Guang Liu, Zhengduo Yang, Yan Li, Fei Fei, Shiwu Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma

Yuan-Chiang Chung, Wan-Chen Wei, Shin-Han Huang, Chi-Min Shih, Chih-Ping Hsu, King-Jen Chang, Wei-Ting Chao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

CDK11p58inhibits ERα-positive breast cancer invasion by targeting integrin β3 via the repression of ERα signaling

Yayun Chi, Sheng Huang, Lei Wang, Ruoji Zhou, Lisha Wang, Xiuying Xiao, Dali Li, Ying Cai, Xiaoyan Zhou, Jiong Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cancer awareness and socio-economic position: results from a population-based study in Denmark

Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff, Peter Vedsted

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Predicting invasive breast cancer versus DCIS in different age groups

Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske, Elizabeth S Burnside

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression

Dirk Rades, Jasmin N Evers, Volker Rudat, Amira Bajrovic, Johann H Karstens, Steven E Schild

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells

Ke Jiang, Yingchun Li, Qiumin Zhu, Jiansheng Xu, Yupeng Wang, Wuguo Deng, Quentin Liu, Guirong Zhang, Songshu Meng

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Expression of A disintegrin and metalloprotease 8 is associated with cell growth and poor survival in colorectal cancer

Zuli Yang, Yang Bai, Lijun Huo, Hao Chen, Jintuan Huang, Jizheng Li, Xinjuan Fan, Zihuan Yang, Lei Wang, Jianping Wang

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity

Masataka Matsumoto, Takashi Nakayama, Daiki Inoue, Kazufumi Takamatsu, Ryo Itotani, Manabu Ishitoko, Shinko Suzuki, Minoru Sakuramoto, Yoshiaki Yuba, Osamu Yoshie, Masaya Takemura, Motonari Fukui

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differentiation of bland from neoplastic thrombus of the portal vein in patients with hepatocellular carcinoma: application of susceptibility-weighted MR imaging

Chuanming Li, Jiani Hu, Daiquan Zhou, Jun Zhao, Kuansheng Ma, Xuntao Yin, Jian Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A longitudinal study investigating quality of life and nutritional outcomes in advanced cancer patients receiving home parenteral nutrition

Pankaj G Vashi, Sadie Dahlk, Brenten Popiel, Carolyn A Lammersfeld, Carol Ireton-Jones, Digant Gupta

01.12.2014 | Debate | Ausgabe 1/2014 Open Access

The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies

Bernd Krone, Klaus F Kölmel, John M Grange

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Regional variation in breast cancer treatment in the Netherlands and the role of external peer review: a cohort study comprising 63,516 women

Melvin J Kilsdonk, Boukje AC van Dijk, Renee Otter, Wim H van Harten, Sabine Siesling

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic implication of intratumoral metabolic heterogeneity in invasive ductal carcinoma of the breast

Seung Hyun Son, Do-Hoon Kim, Chae Moon Hong, Choon-Young Kim, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Comparative effectiveness of approved first-line anti-angiogenic and molecularly targeted therapeutic agents in the treatment of good and intermediate risk metastatic clear cell renal cell carcinoma

Benjamin Haaland, Akhil Chopra, Sanchalika Acharyya, André P Fay, Gilberto de Lima Lopes

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Real world costs and cost-effectiveness of Rituximab for diffuse large B-cell lymphoma patients: a population-based analysis

Sara Khor, Jaclyn Beca, Murray Krahn, David Hodgson, Linda Lee, Michael Crump, Karen E Bremner, Jin Luo, Muhammad Mamdani, Chaim M Bell, Carol Sawka, Scott Gavura, Terrence Sullivan, Maureen Trudeau, Stuart Peacock, Jeffrey S Hoch

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Phenethyl isothiocyanate upregulates death receptors 4 and 5 and inhibits proliferation in human cancer stem-like cells

Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen, Moul Dey

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The structure and demographic correlates of cancer fear

Charlotte Vrinten, Cornelia H M van Jaarsveld, Jo Waller, Christian von Wagner, Jane Wardle

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

B7-H3 expression in colorectal cancer: associations with clinicopathological parameters and patient outcome

Vibeke A Ingebrigtsen, Kjetil Boye, Jahn M Nesland, Arild Nesbakken, Kjersti Flatmark, Øystein Fodstad

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Blood transcript analysis and metastatic recurrent small bowel carcinoid management

Irvin M Modlin, Ignat Drozdov, Lisa Bodei, Mark Kidd

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients

Remco S Derr, Anneke Q van Hoesel, Anne Benard, Inès J Goossens-Beumer, Anita Sajet, N Geeske Dekker-Ensink, Esther M de Kruijf, Esther Bastiaannet, Vincent THBM Smit, Cornelis JH van de Velde, Peter JK Kuppen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A VELOUR post hoc subset analysis: prognostic groups and treatment outcomes in patients with metastatic colorectal cancer treated with aflibercept and FOLFIRI

Ian Chau, Florence Joulain, Sheikh Usman Iqbal, John Bridgewater

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Correlation between ERK1 and STAT3 expression and chemoresistance in patients with conventional osteosarcoma

Sébastien Salas, Carine Jiguet-Jiglaire, Loic Campion, Catherine Bartoli, Frédéric Frassineti, Jean-Laurent Deville, André Maues De Paula, Fabien Forest, Pascal Jézéquel, Jean-Claude Gentet, Corinne Bouvier

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MMP-9 expression varies according to molecular subtypes of breast cancer

Einas M Yousef, Muhammad R Tahir, Yves St-Pierre, Louis A Gaboury

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-1246 enhances migration and invasion through CADM1 in hepatocellular carcinoma

Zhao Sun, Changting Meng, Shihua Wang, Na Zhou, Mei Guan, Chunmei Bai, Shan Lu, Qin Han, Robert Chunhua Zhao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein

An Wouters, Bea Pauwels, Natalie Burrows, Marc Baay, Vanessa Deschoolmeester, Trung Nghia Vu, Kris Laukens, Paul Meijnders, Dirk Van Gestel, Kaye J Williams, Danielle Van den Weyngaert, Jan B Vermorken, Patrick Pauwels, Marc Peeters, Filip Lardon

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Variable NF-κB pathway responses in colon cancer cells treated with chemotherapeutic drugs

Temesgen Samuel, Khalda Fadlalla, Dominique N Gales, Balananda DK Putcha, Upender Manne

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling

Yumei Diao, Mohammed Ferdous-Ur Rahman, Victoria E Villegas, Malin Wickström, John I Johnsen, Peter G Zaphiropoulos

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Impact of different surgical and postoperative adjuvant treatment modalities on survival of sinonasal malignant melanoma

Xin-Jun Meng, Hua-Fei Ao, Wei-Ting Huang, Fu Chen, Xi-Cai Sun, Jing-Jing Wang, Zhuo-Fu Liu, Wade W Han, Allison N Fry, De-Hui Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Lack of treatment-related mortality definitions in clinical trials of children, adolescents and young adults with lymphomas, solid tumors and brain tumors: a systematic review

Thai Hoa Tran, Michelle Lee, Sarah Alexander, Paul Gibson, Ute Bartels, Donna L Johnston, Carol Portwine, Marianna Silva, Jason D Pole, Lillian Sung

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Incidental advanced-stage Hodgkin lymphoma diagnosed at the time of radical prostatectomy for prostatic cancer: a case report and review of literature

Antonio Di Meglio, Pier Vitale Nuzzo, Francesco Ricci, Bruno Spina, Francesco Boccardo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

pERK, pAKT and p53 as tissue biomarkers in erlotinib-treated patients with advanced pancreatic cancer: a translational subgroup analysis from AIO-PK0104

Steffen Ormanns, Jens T Siveke, Volker Heinemann, Michael Haas, Bence Sipos, Anna Melissa Schlitter, Irene Esposito, Andreas Jung, Rüdiger P Laubender, Stephan Kruger, Ursula Vehling-Kaiser, Cornelia Winkelmann, Ludwig Fischer von Weikersthal, Michael R Clemens, Thomas C Gauler, Angela Märten, Michael Geissler, Tim F Greten, Thomas Kirchner, Stefan Boeck

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Combination of hepatocyte specific delivery and transformation dependent expression of shRNA inducing transcriptional gene silencing of c-Myc promoter in hepatocellular carcinoma cells

Mohammad Khalid Zakaria, Imran Khan, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar, Subrata Sinha

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

PARP inhibition and the radiosensitizing effects of the PARP inhibitor ABT-888 in in vitrohepatocellular carcinoma models

Clément Guillot, Vincent Favaudon, Zdenko Herceg, Charlotte Sagne, Sylvie Sauvaigo, Philippe Merle, Janet Hall, Isabelle Chemin

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Synergetic cytotoxic activity toward breast cancer cells enhanced by the combination of Antp-TPR hybrid peptide targeting Hsp90 and Hsp70-targeted peptide

Tomohisa Horibe, Aya Torisawa, Masayuki Kohno, Koji Kawakami

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Down-regulation of argininosuccinate synthetase is associated with cisplatin resistance in hepatocellular carcinoma cell lines: implications for PEGylated arginine deiminase combination therapy

Jennifer A McAlpine, Hsin-Tze Lu, Katherine C Wu, Susan K Knowles, James A Thomson

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

TACE performed in patients with a single nodule of Hepatocellular Carcinoma

Eleonora Terzi, Fabio Piscaglia, Ludovica Forlani, Cristina Mosconi, Matteo Renzulli, Luigi Bolondi, Rita Golfieri, BLOG-Bologna Liver Oncology Group, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-181b sensitizes glioma cells to teniposide by targeting MDM2

Yan-chang Sun, Jing Wang, Cheng-cheng Guo, Ke Sai, Jian Wang, Fu-rong Chen, Qun-ying Yang, Yin-sheng Chen, Jie Wang, Tony Shing-shun To, Zong-ping Zhang, Yong-gao Mu, Zhong-ping Chen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer

Theresa L Wellman, Midori Eckenstein, Cheung Wong, Mercedes Rincon, Takamaru Ashikaga, Sharon L Mount, Christopher S Francklyn, Karen M Lounsbury

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A study of docetaxel and irinotecan in children and young adults with recurrent or refractory Ewing sarcoma family of tumors

Jong Hyung Yoon, Mi Mi Kwon, Hyeon Jin Park, Seog Yun Park, Kun Young Lim, Jungnam Joo, Byung-Kiu Park

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Macrophage migration inhibitory factor engages PI3K/Akt signalling and is a prognostic factor in metastatic melanoma

Camila S Oliveira, Charles E de Bock, Timothy J Molloy, Elham Sadeqzadeh, Xin Yan Geng, Peter Hersey, Xu Dong Zhang, Rick F Thorne

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinical Phase I/II trial to Investigate Preoperative Dose-Escalated Intensity-Modulated Radiation Therapy (IMRT) and Intraoperative Radiation Therapy (IORT) in patients with retroperitoneal soft tissue sarcoma: interim analysis

Falk Roeder, Alexis Ulrich, Gregor Habl, Matthias Uhl, Ladan Saleh-Ebrahimi, Peter E Huber, Daniela Schulz-Ertner, Anna V Nikoghosyan, Ingo Alldinger, Robert Krempien, Gunhild Mechtersheimer, Frank W Hensley, Juergen Debus, Marc Bischof

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Evaluation of the walk-through inflatable colon as a colorectal cancer education tool: results from a pre and post research design

Janeth I Sanchez, Rebecca Palacios, Adrianna Cole, Mary A O’Connell

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

A collagen-fibrin patch (Tachosil®) for the prevention of symptomatic lymphoceles after pelvic lymphadenectomy in women with gynecologic malignancies: a randomized clinical trial

Christoph Grimm, Stephan Polterauer, Samir Helmy, David Cibula, Michal Zikan, Alexander Reinthaller, Clemens Tempfer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model

Elina Korpela, Darren Yohan, Lee CL Chin, Anthony Kim, Xiaoyong Huang, Shachar Sade, Paul Van Slyke, Daniel J Dumont, Stanley K Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor

Yuli Lin, Nana Peng, Hongqin Zhuang, Di Zhang, Yao Wang, Zi-Chun Hua

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The association of time between diagnosis and major resection with poorer colorectal cancer survival: a retrospective cohort study

Maria Theresa Redaniel, Richard M Martin, Jane M Blazeby, Julia Wade, Mona Jeffreys

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Differential subcellular and extracellular localisations of proteins required for insulin-like growth factor- and extracellular matrix-induced signalling events in breast cancer progression

Helen C Plant, Abhishek S Kashyap, Kerry J Manton, Brett G Hollier, Cameron P Hurst, Sandra R Stein, Glenn D Francis, Geoffrey F Beadle, Zee Upton, David I Leavesley

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A computational model to predict bone metastasis in breast cancer by integrating the dysregulated pathways

Xionghui Zhou, Juan Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Effect and safety of dual anti-human epidermal growth factor receptor 2 therapy compared to monotherapy in patients with human epidermal growth factor receptor 2-positive breast cancer: a systematic review

Xiao Zhang, Xin-Ji Zhang, Tian-Yi Zhang, Fei-Fei Yu, Xin Wei, Ye-Sheng Li, Jia He

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology

Armelle Dufresne, Laurent Alberti, Mehdi Brahmi, Sarah Kabani, Héloïse Philippon, David Pérol, Jean Yves Blay

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic prediction of glioblastoma by quantitative assessment of the methylation status of the entire MGMT promoter region

Manabu Kanemoto, Mitsuaki Shirahata, Akiyo Nakauma, Katsumi Nakanishi, Kazuya Taniguchi, Yoji Kukita, Yoshiki Arakawa, Susumu Miyamoto, Kikuya Kato

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High-resolution melting analysis reveals genetic polymorphisms in MicroRNAs confer hepatocellular carcinoma risk in Chinese patients

Jia-Hui Qi, Jin Wang, Jinyun Chen, Fan Shen, Jing-Tao Huang, Subrata Sen, Xin Zhou, Song-Mei Liu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Fast-track surgery versus traditional perioperative care in laparoscopic colorectal cancer surgery: a meta-analysis

Jun-hua Zhao, Jing-xu Sun, Peng Gao, Xiao-wan Chen, Yong-xi Song, Xuan-zhang Huang, Hui-mian Xu, Zhen-ning Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Clinicopathological features and EGFR gene mutation status in elderly patients with resected non–small-cell lung cancer

Teppei Nishii, Tomoyuki Yokose, Yohei Miyagi, Yataro Daigo, Hiroyuki Ito, Tetsuya Isaka, Kentaro Imai, Shuji Murakami, Tetsuro Kondo, Haruhiro Saito, Fumihiro Oshita, Kouzo Yamada, Shoichi Matsukuma, Masahiro Tsuboi, Haruhiko Nakayama, Munetaka Masuda

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Polysialic acid is associated with better prognosis and IDH1-mutation in diffusely infiltrating astrocytomas

Katri Mäkelä, Kristiina Nordfors, Jukka Finne, Anne Jokilammi, Timo Paavonen, Hannu Haapasalo, Miikka Korja, Joonas Haapasalo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

GPC3 reduces cell proliferation in renal carcinoma cell lines

Marina Curado Valsechi, Ana Beatriz Bortolozo Oliveira, André Luis Giacometti Conceição, Bruna Stuqui, Natalia Maria Candido, Paola Jocelan Scarin Provazzi, Luiza Ferreira de Araújo, Wilson Araújo Silva Jr, Marilia de Freitas Calmon, Paula Rahal

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2

Xiaoshan Feng, Ying Wang, Zhikun Ma, Ruina Yang, Shuo Liang, Mengxi Zhang, Shiyuan Song, Shuoguo Li, Gang Liu, Daiming Fan, Shegan Gao

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Population-based cohort study on the risk of malignancy in East Asian children with Juvenile idiopathic arthritis

Victor C Kok, Jorng-Tzong Horng, Jing-Long Huang, Kuo-Wei Yeh, Jia-Jing Gau, Cheng-Wei Chang, Lai-Zhen Zhuang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Intratumoral heterogeneity impacts the response to anti-neu antibody therapy

Hyunkeun Song, Tae Oh Kim, Sun Young Ma, Jin-Hee Park, Jae-Hyug Choi, Jin-Ho Kim, Mi Seon Kang, Sang Kyun Bae, Ki Hyaung Kim, Tae Hyun Kim, Su-Kil Seo, Il Whan Choi, Geun Am Song, Eric D Mortenson, Yang-Xin Fu, SaeGwang Park

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Co-expression of putative stemness and epithelial-to-mesenchymal transition markers on single circulating tumour cells from patients with early and metastatic breast cancer

Maria A Papadaki, Galatea Kallergi, Zafeiris Zafeiriou, Lefteris Manouras, Panayiotis A Theodoropoulos, Dimitris Mavroudis, Vassilis Georgoulias, Sofia Agelaki

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Chromosomal imbalances in human bladder urothelial carcinoma: similarities and differences between biopsy samples and cancer stem-like cells

Donatella Conconi, Elena Panzeri, Serena Redaelli, Giorgio Bovo, Paolo Viganò, Guido Strada, Leda Dalprà, Angela Bentivegna

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A new T classification based on masticator space involvement in nasopharyngeal carcinoma: a study of 742 cases with magnetic resonance imaging

Dong-Hua Luo, Jing Yang, Hui-Zhi Qiu, Ting Shen, Qiu-Yan Chen, Pei-Yu Huang, Rui Sun, Chao-Nan Qian, Hai-Qiang Mai, Xiang Guo, Hao-Yuan Mo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic model for predicting overall survival in children and adolescents with rhabdomyosarcoma

Limin Yang, Tetsuya Takimoto, Junichiro Fujimoto

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

DNA methylation gene-based models indicating independent poor outcome in prostate cancer

Nataša Vasiljević, Amar S Ahmad, Mangesh A Thorat, Gabrielle Fisher, Daniel M Berney, Henrik Møller, Christopher S Foster, Jack Cuzick, Attila T Lorincz

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Cancer suspicion in general practice, urgent referral and time to diagnosis: a population-based GP survey and registry study

Henry Jensen, Marie Louise Tørring, Frede Olesen, Jens Overgaard, Peter Vedsted

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Time trends of cancer incidence in Setif, Algeria, 1986–2010: an observational study

Mokhtar Hamdi Cherif, Diego Serraino, Abbes Mahnane, Slimane Laouamri, Zoubida Zaidi, Hafida Boukharouba, Dahbia Cherka, Manel Rakeb, Lamia Kara, Asma Ayat, Silvia Birri, Saverio Virdone, Paolo De Paoli, Ettore Bidoli

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High expression of GEM and EDNRA is associated with metastasis and poor outcome in patients with advanced bladder cancer

Jens Reumert Laurberg, Jørgen Bjerggaard Jensen, Troels Schepeler, Michael Borre, Torben F Ørntoft, Lars Dyrskjøt

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells

Nicolás Tobar, Marcela Toyos, Carla Urra, Nicolás Méndez, Rodrigo Arancibia, Patricio C Smith, Jorge Martínez

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A multi-institutional study of the prevalence of BRCA1 and BRCA2 large genomic rearrangements in familial breast cancer patients

Moon-Woo Seong, Sung Im Cho, Kyu Hyung Kim, Il Yong Chung, Eunyoung Kang, Jong Won Lee, Sue K Park, Min Hyuk Lee, Doo Ho Choi, Cha Kyong Yom, Woo-Chul Noh, Myung Chul Chang, Sung Sup Park, Sung-Won Kim, Korean Hereditary Breast Cancer Study Group

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The prognostic importance of jaundice in surgical resection with curative intent for gallbladder cancer

Xin-wei Yang, Jian-mao Yuan, Jun-yi Chen, Jue Yang, Quan-gen Gao, Xing-zhou Yan, Bao-hua Zhang, Shen Feng, Meng-chao Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Stereotactic Ablative Radiotherapy (SABR) in inoperable oligometastatic disease from colorectal cancer: a safe and effective approach

Tiziana Comito, Luca Cozzi, Elena Clerici, Maria Concetta Campisi, Rocco Luca Emanuele Liardo, Pierina Navarria, AnnaMaria Ascolese, Angelo Tozzi, Cristina Iftode, Fiorenza De Rose, Elisa Villa, Nicola Personeni, Lorenza Rimassa, Armando Santoro, Antonella Fogliata, Pietro Mancosu, Stefano Tomatis, Marta Scorsetti

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MiR-107 and miR-99a-3p predict chemotherapy response in patients with advanced colorectal cancer

Sonia Molina-Pinelo, Amancio Carnero, Fernando Rivera, Purificacion Estevez-Garcia, Juan Manuel Bozada, Maria Luisa Limon, Marta Benavent, Javier Gomez, Maria Dolores Pastor, Manuel Chaves, Rocio Suarez, Luis Paz-Ares, Fernando de la Portilla, Andres Carranza-Carranza, Isabel Sevilla, Luis Vicioso, Rocio Garcia-Carbonero

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Src activity is modulated by oxaliplatin and correlates with outcomes after hepatectomy for metastatic colorectal cancer

Scott Kopetz, Van K Morris, Nila Parikh, Michael J Overman, Zhi-Qin Jiang, Dipen Maru, Paul Elvin, Gary Gallick

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Access to care issues adversely affect breast cancer patients in Mexico: oncologists’ perspective

Yanin Chavarri-Guerra, Jessica St Louis, Pedro ER Liedke, Heather Symecko, Cynthia Villarreal-Garza, Alejandro Mohar, Dianne M Finkelstein, Paul E Goss

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

Giovanna Forte, Valentina Grossi, Valentina Celestini, Giuseppe Lucisano, Marco Scardapane, Dora Varvara, Margherita Patruno, Rosanna Bagnulo, Daria Loconte, Laura Giunti, Antonio Petracca, Sabrina Giglio, Maurizio Genuardi, Fabio Pellegrini, Nicoletta Resta, Cristiano Simone

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

microRNA alterations in ALDH positive mammary epithelial cells: a crucial contributing factor towards breast cancer risk reduction in case of early pregnancy

Sushmita Bose Nandy, Ramadevi Subramani, Venkatesh Rajamanickam, Rebecca Lopez-Valdez, Arunkumar Arumugam, Thiyagarajan Boopalan, Rajkumar Lakshmanaswamy

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

High serum levels of Dickkopf-1 are associated with a poor prognosis in prostate cancer patients

Tilman D Rachner, Stefanie Thiele, Andy Göbel, Andrew Browne, Susanne Fuessel, Kati Erdmann, Manfred P Wirth, Michael Fröhner, Tilman Todenhöfer, Michael H Muders, Matthias Kieslinger, Martina Rauner, Lorenz C Hofbauer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A selenosemicarbazone complex with copper efficiently down-regulates the 90-kDa heat shock protein HSP90AA1 and its client proteins in cancer cells

Hongtao Shen, Haichuan Zhu, Mowei Song, Yonglu Tian, Yafei Huang, Hui Zheng, Ruiyuan Cao, Jian Lin, Zhenggang Bi, Wu Zhong

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The immunosignature of canine lymphoma: characterization and diagnostic application

Stephen Albert Johnston, Douglas H Thamm, Joseph Barten Legutki

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Risk of breast cancer and family history of other cancers in first-degree relatives in Chinese women: a case control study

Wenbin Zhou, Qiang Ding, Hong Pan, Naping Wu, Mengdi Liang, Yaoyu Huang, Lin Chen, Xiaoming Zha, Xiaoan Liu, Shui Wang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma

Gustaf Lindgren, Lars Ekblad, Johan Vallon-Christersson, Elisabeth Kjellén, Maria Gebre-Medhin, Johan Wennerberg

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Acetylcholinesterase overexpression mediated by oncolytic adenovirus exhibited potent anti-tumor effect

Haineng Xu, Zhengxuan Shen, Jing Xiao, Yu Yang, Weidan Huang, Zhiming Zhou, Jiani Shen, Yizhun Zhu, Xin-Yuan Liu, Liang Chu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Prognostic and therapeutic significance of ribonucleotide reductase small subunit M2 in estrogen-negative breast cancers

Hang Zhang, Xiyong Liu, Charles D Warden, Yasheng Huang, Sofia Loera, Lijun Xue, Suzhan Zhang, Peiguo Chu, Shu Zheng, Yun Yen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Epstein-Barr virus infection and clinical outcome in breast cancer patients correlate with immune cell TNF-α/IFN-γ response

Gina Marrão, Mohammed Habib, Artur Paiva, Dominique Bicout, Catherine Fallecker, Sofia Franco, Samira Fafi-Kremer, Teresa Simões da Silva, Patrice Morand, Carlos Freire de Oliveira, Emmanuel Drouet

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Postoperative nomogram to predict the probability of metastasis in Enneking stage IIB extremity osteosarcoma

Seung Hyun Kim, Kyoo-Ho Shin, Ha Yan Kim, Yong Jin Cho, Jae Kyoung Noh, Jin-Suck Suh, Woo-Ick Yang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Comparison of two threshold detection criteria methodologies for determination of probe positivity for intraoperative in situ identification of presumed abnormal 18F-FDG-avid tissue sites during radioguided oncologic surgery

Gregg J Chapman, Stephen P Povoski, Nathan C Hall, Douglas A Murrey Jr, Robert Lee, Edward W Martin Jr

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Leukemoid reaction in cervical cancer: a case report and review of the literature

Li Qing, Tao Xiang, Zhang Guofu, Feng Weiwei

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Contrast enhanced computed tomography is indicative for angiogenesis pattern and display prognostic significance in breast cancer

Jianyi Li, Yang Zhang, Wenhai Zhang, Yang Gao, Shi Jia, Jiao Guo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Multi-transcript profiling in archival diagnostic prostate cancer needle biopsies to evaluate biomarkers in non-surgically treated men

Naveen Kachroo, Anne Y Warren, Vincent J Gnanapragasam

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

Surveillance or metastasis-directed Therapy for OligoMetastatic Prostate cancer recurrence (STOMP): study protocol for a randomized phase II trial

Karel Decaestecker, Gert De Meerleer, Filip Ameye, Valerie Fonteyne, Bieke Lambert, Steven Joniau, Louke Delrue, Ignace Billiet, Wim Duthoy, Sarah Junius, Wouter Huysse, Nicolaas Lumen, Piet Ost

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

MicroRNA-27a promotes proliferation and suppresses apoptosis by targeting PLK2in laryngeal carcinoma

Yuan Tian, Shuang Fu, Guang-Bin Qiu, Zhen-Ming Xu, Ning Liu, Xiao-Wen Zhang, Sheng Chen, Ye Wang, Kai-Lai Sun, Wei-Neng Fu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Association of leukocyte mitochondrial DNA content with glioma risk: evidence from a Chinese case–control study

Jie Zhang, Deyang Li, Falin Qu, Yibing Chen, Gang Li, Hequn Jiang, Xiaojun Huang, Hushan Yang, Jinliang Xing

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Relative mortality in soft tissue sarcoma patients: a Danish population-based cohort study

Katja Maretty-Nielsen, Ninna Aggerholm-Pedersen, Johnny Keller, Akmal Safwat, Steen Baerentzen, Alma B Pedersen

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

PIN3 duplication may be partially responsible for TP53haploinsufficiency

Marta Winiecka-Klimek, Malgorzata Szybka, Piotr Rieske, Sylwester Piaskowski, Michal Bienkowski, Maciej Walczak, Marcin Pacholczyk, Michal Rostkowski, Jolanta Zieba, Mateusz Banaszczyk, Krystyna Hulas-Bigoszewska, Joanna Peciak, Rafal Pawliczak, Ewelina Stoczynska-Fidelus

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Immunohistochemical detection improves the prognostic value of lymphatic and blood vessel invasion in primary ductal breast cancer

Fadia J A Gujam, James J Going, Zahra M A Mohammed, Clare Orange, Joanne Edwards, Donald C McMillan

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells

Zhenfeng Duan, Jianming Zhang, Shunan Ye, Jacson Shen, Edwin Choy, Gregory Cote, David Harmon, Henry Mankin, Yingqi Hua, Yu Zhang, Nathanael S Gray, Francis J Hornicek

01.12.2014 | Study protocol | Ausgabe 1/2014 Open Access

A randomized phase II clinical trial of nab-paclitaxel and carboplatin compared with gemcitabine and carboplatin as first-line therapy in locally advanced or metastatic squamous cell carcinoma of lung

Jin-Ji Yang, Cheng Huang, Gong-Yan Chen, Yong Song, Ying Cheng, Hong-Hong Yan, Qing Zhou, Yi-Long Wu

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Tongue carcinoma infrequently harbor common actionable genetic alterations

Daniel SW Tan, Weining Wang, Hui Sun Leong, Pui Hoon Sew, Dawn P Lau, Fui Teen Chong, Sai Sakktee Krisna, Tony KH Lim, N Gopalakrishna Iyer

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Jacarelhyperol A induced apoptosis in leukaemia cancer cell through inhibition the activity of Bcl-2 proteins

Shoude Zhang, Jun Yin, Xia Li, Jigang Zhang, Rongcai Yue, Yanyan Diao, Honglin Li, Hui Wang, Lei Shan, Weidong Zhang

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

In vitro evaluation of novel N-acetylalaninate prodrugs that selectively induce apoptosis in prostate cancer cells

Christopher A McGoldrick, Yu-Lin Jiang, Marianne Brannon, Koyamangalath Krishnan, William L Stone

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Fibulin-1 is epigenetically down-regulated and related with bladder cancer recurrence

Wei Xiao, Ji Wang, Heng Li, Ding Xia, Gan Yu, Weimin Yao, Yang Yang, Haibing Xiao, Bin Lang, Xin Ma, Xiaolin Guo, Wei Guan, Hua Xu, Jihong Liu, Xu Zhang, Zhangqun Ye

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The efficacy and safety of crizotinib in the treatment of anaplastic lymphoma kinase-positive non-small cell lung cancer: a meta-analysis of clinical trials

Haili Qian, Feng Gao, Haijuan Wang, Fei Ma

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells

Chengwu Zeng, Yan Xu, Ling Xu, Xibao Yu, Jingjing Cheng, Lijian Yang, Shaohua Chen, Yangqiu Li

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Pattern of use of radiotherapy for lung cancer: a descriptive study

Isabel Tovar, Jose Expósito, Javier Jaén, Enrique Alonso, Miguel Martínez, Rosa Guerrero, Juan P Arrebola, Rosario Del Moral

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The saga of the many studies wrongly associating mitochondrial DNA with breast cancer

Antonio Salas, Manuel García-Magariños, Ian Logan, Hans-Jürgen Bandelt

01.12.2014 | Case report | Ausgabe 1/2014 Open Access

Paraneoplastic brainstem encephalitis in a patient with exceptionally long course of a metastasized neuroendocrine rectum neoplasm

Michael Boch, Anja Rinke, Peter Rexin, Maria Seipelt, Dörte Brödje, Marvin Schober, Thomas M Gress, Patrick Michl, Sebastian Krug

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states after radiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT

Chowdhury Nusrat Fatema, Songji Zhao, Yan Zhao, Wenwen Yu, Ken-ichi Nishijima, Koichi Yasuda, Yoshimasa Kitagawa, Nagara Tamaki, Yuji Kuge

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

Hanna Sallinen, Tommi Heikura, Jonna Koponen, Veli-Matti Kosma, Seppo Heinonen, Seppo Ylä-Herttuala, Maarit Anttila

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Population mixing for leukaemia, lymphoma and CNS tumours in teenagers and young adults in England, 1996–2005

Marlous van Laar, Daniel P Stark, Patricia McKinney, Roger C Parslow, Sally E Kinsey, Susan V Picton, Richard G Feltbower

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

ALDH1A1 overexpression is associated with the progression and prognosis in gastric cancer

Xiao-shan Li, Qing Xu, Xiang-yang Fu, Wei-sheng Luo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)

Margherita Nannini, Annalisa Astolfi, Milena Urbini, Valentina Indio, Donatella Santini, Michael C Heinrich, Christopher L Corless, Claudio Ceccarelli, Maristella Saponara, Anna Mandrioli, Cristian Lolli, Giorgio Ercolani, Giovanni Brandi, Guido Biasco, Maria A Pantaleo

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

microRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18

Keng Zhong, Kun Chen, Lin Han, Bailing Li

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Physical activity and renal cell carcinoma among black and white Americans: a case-control study

Qian Xiao, Linda Liao, Charles E Matthews, Wong-Ho Chow, Faith Davis, Kendra Schwartz, Mark Purdue, Jonathan N Hofmann, Joanne Colt

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer

Lingling Xu, Minzhe Li, Min Wang, Dong Yan, Guosheng Feng, Guangyu An

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A serum mesothelin level is a prognostic indicator for patients with malignant mesothelioma in routine clinical practice

Mark Linch, Spyridon Gennatas, Stanislav Kazikin, Jhangir Iqbal, Ranga Gunapala, Kathryn Priest, Joanne Severn, Alison Norton, Bee Ayite, Jaishree Bhosle, Mary O’Brien, Sanjay Popat

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-κB signaling

Jiangbo Liu, Jiguang Ma, Zheng Wu, Wei Li, Dong Zhang, Liang Han, Fengfei Wang, Katie M Reindl, Erxi Wu, Qingyong Ma

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

A multi-center population-based case–control study of ovarian cancer in African-American women: the African American Cancer Epidemiology Study (AACES)

Joellen M Schildkraut, Anthony J Alberg, Elisa V Bandera, Jill Barnholtz-Sloan, Melissa Bondy, Michelle L Cote, Ellen Funkhouser, Edward Peters, Ann G Schwartz, Paul Terry, Kristin Wallace, Lucy Akushevich, Frances Wang, Sydnee Crankshaw, Patricia G Moorman

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Large differences in global transcriptional regulatory programs of normal and tumor colon cells

David Cordero, Xavier Solé, Marta Crous-Bou, Rebeca Sanz-Pamplona, Laia Paré-Brunet, Elisabet Guinó, David Olivares, Antonio Berenguer, Cristina Santos, Ramón Salazar, Sebastiano Biondo, Víctor Moreno

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Proteomic study reveals a functional network of cancer markers in the G1-Stage of the breast cancer cell cycle

Milagros J Tenga, Iulia M Lazar

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Obesity and cancer: the role of vitamin D

Thurkaa Shanmugalingam, Danielle Crawley, Cecilia Bosco, Jennifer Melvin, Sabine Rohrmann, Simon Chowdhury, Lars Holmberg, Mieke Van Hemelrijck

01.12.2014 | Research article | Ausgabe 1/2014 Open Access

Mesenchymal stem cells are efficiently transduced with adenoviruses bearing type 35-derived fibers and the transduced cells with the IL-28A gene produces cytotoxicity to lung carcinoma cells co-cultured

Takeo Suzuki, Kiyoko Kawamura, Quanhai Li, Shinya Okamoto, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi, Masatoshi Tagawa