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BMC Cancer

Ausgabe 1/2019

Inhalt (1254 Artikel)

Open Access Research article

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro, Rosa Noguera

Open Access Research article

A phase II randomized controlled trial of three exercise delivery methods in men with prostate cancer on androgen deprivation therapy

Shabbir M. H. Alibhai, Daniel Santa Mina, Paul Ritvo, George Tomlinson, Catherine Sabiston, Murray Krahn, Sara Durbano, Andrew Matthew, Padraig Warde, Meagan O’Neill, Narhari Timilshina, Roanne Segal, Nicole Culos-Reed

Open Access Research article

Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer

Taro Iwatsubo, Ryu Ishihara, Toshitaka Morishima, Akira Maekawa, Kentaro Nakagawa, Masamichi Arao, Masayasu Ohmori, Hiroyoshi Iwagami, Kenshi Matsuno, Shuntaro Inoue, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Isao Miyashiro, Kazuhide Higuchi, Takashi Fujii

Open Access Research article

Prevalence of BRCA1 and BRCA2 pathogenic and likely pathogenic variants in non-selected ovarian carcinoma patients in Brazil

Deborah Porto Cotrim, Adriana Regina Gonçalves Ribeiro, Daniele Paixão, Diogo Cordeiro de Queiroz Soares, Rima Jbili, Natasha Carvalho Pandolfi, Camila Cezana, Carine de Cássia Mauro, Henrique Mantoan, Graziele Bovolim, Louise de Brot, Giovana Tardin Torrezan, Dirce Maria Carraro, Glauco Baiocchi, Maria Nirvana da Cruz Formiga, Alexandre A. B. A. da Costa

Open Access Research article

PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114)

Gustavo Werutsky, Bruno Hochhegger, José Antônio Lopes de Figueiredo Pinto, Jeovany Martínez-Mesa, Mara Lise Zanini, Eduardo Herz Berdichevski, Eduardo Vilas, Vinícius Duval da Silva, Maria Teresa Ruiz Tsukazan, Arthur Vieira, Leandro Genehr Fritscher, Louise Hartmann, Marcos Alba, Guilherme Sartori, Cristina Matushita, Vanessa Bortolotto, Rayssa Ruszkowski do Amaral, Luís Carlos Anflor Junior, Facundo Zaffaroni, Carlos H. Barrios, Márcio Debiasi, Carlos Cezar Frietscher

Open Access Research article

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park, Eui-Ju Hong

Open Access Study protocol

A longitudinal mixed methods study on changes in body weight, body composition, and lifestyle in breast cancer patients during chemotherapy and in a comparison group of women without cancer: study protocol

J. Th. C. M. de Kruif, M. Visser, M. M. G. A. van den Berg, M. J. M. Derks, M. R. de Boer, H. W. M. van Laarhoven, J. H. M. de Vries, Y. C. de Vries, E. Kampman, R. W. Winkels, M. J. Westerman

Open Access Research article

Three-port single-intercostal versus multiple-intercostal thoracoscopic lobectomy for the treatment of lung cancer: a propensity-matched analysis

Zixiang Wu, Qi Wang, Cong Wu, Tianwei Zhan, Lingjun Dong, Shuai Fang, Xuyang Peng, Lian Wang, Saibo Pan, Ming Wu

Open Access Research article

Anti-cancer effect of dung beetle glycosaminoglycans on melanoma

Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jang Mi Jin, Hyung Joo Yoon, Jae Sam Hwang, Kun-Koo Park

Open Access Research article

Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin

Min su You, Ji Kon Ryu, Young Hoon Choi, Jin Ho Choi, Gunn Huh, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim

Open Access Research article

Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma

Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland, Anders Molven

Open Access Research article

Radium-223 in asymptomatic patients with castration-resistant prostate cancer and bone metastases treated in an international early access program

Axel Heidenreich, Silke Gillessen, Daniel Heinrich, Daniel Keizman, Joe M. O’Sullivan, Joan Carles, Manfred Wirth, Kurt Miller, John Reeves, Monica Seger, Sten Nilsson, Fred Saad

Open Access Research article

miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner

Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu, Jianlin Ren

Open Access Research article

Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study

Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang, Wenhua Li

Open Access Research article

Patients with metastatic renal cell carcinoma who benefit from axitinib dose titration: analysis from a randomised, double-blind phase II study

Yoshihiko Tomita, Hirotsugu Uemura, Mototsugu Oya, Nobuo Shinohara, Tomonori Habuchi, Yosuke Fujii, Yoichi Kamei, Yoshiko Umeyama, Angel H. Bair, Brian I. Rini

Open Access Study protocol

Randomized prospective phase III trial of 68Ga-PSMA-11 PET/CT molecular imaging for prostate cancer salvage radiotherapy planning [PSMA-SRT]

Jeremie Calais, Johannes Czernin, Wolfgang P. Fendler, David Elashoff, Nicholas G. Nickols

Open Access Research article

Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors

Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee, Dae Seog Heo

Open Access Research article

Shikonin inhibits cancer cell cycling by targeting Cdc25s

Shoude Zhang, Qiang Gao, Wei Li, Luwei Zhu, Qianhan Shang, Shuo Feng, Junmei Jia, Qiangqiang Jia, Shuo Shen, Zhanhai Su

Open Access Research article

A modified subclassification to evaluate the survival of patients with N3 gastric cancer: an international database study

Man-Qiang Lin, Jia-Bin Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Qing-Liang He, Chang-Ming Huang

Open Access Research article

Time trend of breast cancer mortality in BRAZILIAN men: 10-year data analysis from 2005 to 2015

Jean Henri Maselli-Schoueri, Fernando Alves Affonso-Kaufman, Claudia Vaz de Melo Sette, Francisco Winter dos Santos Figueiredo, Fernando Adami

Open Access Research article

Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study

Gui-Cen Liu, Yun-Fei Zhou, Xiao-Chao Su, Jun Zhang

Open Access Research article

Patient and carer perceived barriers to early presentation and diagnosis of lung cancer: a systematic review

Shemana Cassim, Lynne Chepulis, Rawiri Keenan, Jacquie Kidd, Melissa Firth, Ross Lawrenson

Open Access Research article

Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells

Xiaofu Qiu, Wei Wang, Bijun Li, Bo Cheng, Kangjian Lin, Jian Bai, Huanhui Li, Guosheng Yang

Open Access Research article

Nab-paclitaxel and gemcitabine or FOLFIRINOX as first-line treatment in patients with unresectable adenocarcinoma of the pancreas: does sequence matter?

Ursula M. Vogl, Haleh Andalibi, Alexander Klaus, Laurenz Vormittag, Wolfgang Schima, Bettina Heinrich, Alice Kafka, Thomas Winkler, Leopold Öhler

Open Access Research article

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα

He Xin, Chuanzhuo Wang, Zhaoyu Liu

Open Access Research article

Development of mini-SSPedi for children 4–7 years of age receiving cancer treatments

Deborah Tomlinson, Shannon Hyslop, Eliana Stein, Brenda Spiegler, Emily Vettese, Susan Kuczynski, Tal Schechter, L. Lee Dupuis, Lillian Sung

Open Access Research article

Risk factors for surgical site infection after malignant bone tumor resection and reconstruction

Shinji Miwa, Toshiharu Shirai, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kaoru Tada, Yoshitomo Kajino, Takashi Higuchi, Kensaku Abe, Hisaki Aiba, Yuta Taniguchi, Hiroyuki Tsuchiya

Open Access Research article

Development of a miRNA-seq based prognostic signature in lung adenocarcinoma

Chathura Siriwardhana, Vedbar S. Khadka, John J. Chen, Youping Deng

Open Access Research article

Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study

Shouchun Yan, Rong Sun, Shan Wu, Tianbo Jin, Shanshan Zhang, Fanglin Niu, Jingjie Li, Mingwei Chen

Open Access Case report

Metastases to extraocular muscles from breast cancer: case report and up-to-date review of the literature

Marialuisa Framarino-dei-Malatesta, Annalisa Chiarito, Federico Bianciardi, Marco Fiorelli, Azzurra Ligato, Giuseppe Naso, Irene Pecorella

Open Access Research article

Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area

Ji-Jin Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen, Wang-Jian Zhang, Wayne R. Lawrence, Fan Zhang, Si-Yang Wang, Ying Sun, Guan-Qun Zhou

Open Access Research article

HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

Patrick Sven Plum, Florian Gebauer, Max Krämer, Hakan Alakus, Felix Berlth, Seung-Hun Chon, Lars Schiffmann, Thomas Zander, Reinhard Büttner, Arnulf Heinrich Hölscher, Christiane Josephine Bruns, Alexander Quaas, Heike Loeser

Open Access Research article

Real world evidence on gemcitabine and nab-paclitaxel combination chemotherapy in advanced pancreatic cancer

Hakon Blomstrand, Ursula Scheibling, Charlotte Bratthäll, Henrik Green, Nils O. Elander

Open Access Research article

Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber, Simone Muenst

Open Access Research article

Disparities in breast cancer diagnosis for immigrant women in Ontario and BC: results from the CanIMPACT study

A. K. Lofters, M. L. McBride, D. Li, M. Whitehead, R. Moineddin, L. Jiang, E. Grunfeld, P. A. Groome, Natalie Biswanger, Kathleen Decker, Cynthia Kendell, Monika Krzyzanowska, Sharon Nicole Mittmann Matthias, Geoff Porter, Dawn Powell, Donna Turner, Bonnie Vick, Marcy Winget, Yan Yuan

Open Access Research article

Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1

Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen, Walter H. Gotlieb

Open Access Research article

Lymph node positivity in different early breast carcinoma phenotypes: a predictive model

Gilles Houvenaeghel, Eric Lambaudie, Jean-Marc Classe, Chafika Mazouni, Sylvia Giard, Monique Cohen, Christelle Faure, Hélène Charitansky, Roman Rouzier, Emile Daraï, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Marc Martino, Jean Fraisse, François Dravet, Marie Pierre Chauvet, Jean Marie Boher

Open Access Research article

Trends in the incidence and mortality of transitional cell carcinoma of the bladder for the last four decades in the USA: a SEER-based analysis

Muneer J. Al-Husseini, Ahmad Kunbaz, Anas M. Saad, João Vasco Santos, Sami Salahia, Marium Iqbal, Fares Alahdab

Open Access Research article

oipA “on” status of Helicobacter pylori is associated with gastric cancer in North-Eastern Brazil

Lúcia Libanez Bessa Campelo Braga, Maria Helane Rocha Batista, Orleâncio Gomes Ripardo de Azevedo, Kassiane Cristine da Silva Costa, Adriana Dias Gomes, Gifone Aguiar Rocha, Dulciene Maria Magalhães Queiroz

Open Access Research article

Differential expression of TIM-3 between primary and metastatic sites in renal cell carcinoma

Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Kunpeng Shu, Jinge Zhao, Peng Zhao, Ni Chen, Jia Wang, Pengfei Shen, Hao Zeng

Open Access Case report

A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review

Monica Piedimonte, Tiziana Ottone, Valentina Alfonso, Antonella Ferrari, Esmeralda Conte, Mariadomenica Divona, Maria Paola Bianchi, Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Alessia Campagna, Laura Cicconi, Giulia Galassi, Sabrina Pelliccia, Annapaola Leporace, Francesco Lo Coco, Agostino Tafuri

Open Access Case report

Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review

Masanobu Abe, Kousuke Watanabe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Takahiro Abe, Yuko Fujihara, Yosuke Amano, Liang Zong, Cheng-Ping Wang, Emi Kubo, Ryoko Inaki, Naoya Kinoshita, Satoshi Yamashita, Daiya Takai, Toshikazu Ushijima, Takahide Nagase, Kazuto Hoshi

Open Access Research article

Association between male pattern baldness and testicular germ cell tumor: a meta-analysis

Jiatong Zhou, Shuai Xia, Tao Li, Ranlu Liu

Open Access Research article

Statin use and breast cancer survival – a Swedish nationwide study

Signe Borgquist, Per Broberg, Jasaman Tojjar, Håkan Olsson

Open Access Research article

Safety and efficacy of afatinib as add-on to standard therapy of gemcitabine/cisplatin in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, phase I trial with an extensive biomarker program

Markus Moehler, Annett Maderer, Anne Ehrlich, Friedrich Foerster, Arno Schad, Tanja Nickolay, Christian Ruckes, Arndt Weinmann, Visvakanth Sivanathan, Jens U. Marquardt, Peter Robert Galle, Marcus Woerns, Thomas Thomaidis

Open Access Correction

Correction to: Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi

Open Access Study protocol

Evaluation of effectiveness of the PlasmaJet surgical device in the treatment of advanced stage ovarian cancer (PlaComOv-study): study protocol of a randomized controlled trial in the Netherlands

G. M. Nieuwenhuyzen-de Boer, W. Hofhuis, N. Reesink-Peters, P. C. Ewing-Graham, I. G. Schoots, J. J. Beltman, J. M. J. Piek, A. Baalbergen, G. S. Kooi, A. van Haaften, H. van Huisseling, L. Haans, M. Dorman, H. J. van Beekhuizen

Open Access Research article

Optimal chemo-mobilization for the collection of peripheral blood stem cells in patients with multiple myeloma

Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Seung-Yeon Jung, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee

Open Access Research article

Abiraterone acetate plus prednisone for the Management of Metastatic Castration-Resistant Prostate Cancer (mCRPC) without prior use of chemotherapy: report from a large, international, real-world retrospective cohort study

Martin Boegemann, Sara Khaksar, Guillaume Bera, Alison Birtle, Catherine Dopchie, Louis-Marie Dourthe, Els Everaert, Martin Hatzinger, Dirko Hercher, Werner Hilgers, Geoffrey Matus, Laura Garcia Alvarez, Laurent Antoni, Martin Lukac, Geneviève Pissart, Paul Robinson, Tony Elliott

Open Access Research article

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad, Mohsen Moghoofei

Open Access Research article

CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process

Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda, Olivia Fromigué

Open Access Research article

Medical oncology outpatients’ preferences and experiences with advanced care planning: a cross-sectional study

Amy Waller, Heidi Turon, Jamie Bryant, Alison Zucca, Tiffany-Jane Evans, Rob Sanson-Fisher

Open Access Research article

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses

Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen, Joseph T. Chang

Open Access Research article

DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma

Emma Andersson Evelönn, Mattias Landfors, Zahra Haider, Linda Köhn, Börje Ljungberg, Göran Roos, Sofie Degerman

Open Access Research article

Tumor growth rate as a metric of progression, response, and prognosis in pancreatic and intestinal neuroendocrine tumors

Clarisse Dromain, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin, Martyn E. Caplin, Austria M. Raderer, Austria M. Raderer, Belgium I. Borbath, D. Ysebaert, E. Sedláčková, P. Vítek, Denmark H. Grønbæk, France A. Adenis, L. Buscail, G. Cadiot, S. Dominguez, M. Ducreux, C. Lombard-Bohas, E. Mitry, P. Ruszniewski, J. F. Seitz, N. Begum, I. Harsch, M. Pavel, C. Schöfl, M. Weber, B. Wiedenmann, M. Mallath, P. Patil, K. Sambasivaiah, R. Saxena, E. Bajetta, A. Buonadonna, R. Buzzoni, R. Cannizzaro, A. Colao, C. De Angelis, P. Tomassetti, J. Ćwikła, B. Kos-Kudła, Slovakia T. Salek, J. Capdevila, G. Soler, J. M. Tabernero, H. Ahlman, M. Kjellman, G. Aithal, A. Anthoney, M. Caplin, A. Grossman, J. Newell-Price, J. Ramage, N. Reed, A. Rees, W. Steward, L. Wall, M. Choti, A. T. Phan, E. M. Wolin

Open Access Research article

Identifying primary site of lung-limited Cancer of unknown primary based on relative gene expression orderings

Mengyao Li, Hongdong Li, Guini Hong, Zhongjie Tang, Guanghao Liu, Xiaofang Lin, Mingzhang Lin, Lishuang Qi, Zheng Guo

Open Access Study protocol

Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma

Houda Bahig, Francine Aubin, John Stagg, Olguta Gologan, Olivier Ballivy, Eric Bissada, Felix-Phuc Nguyen-Tan, Denis Soulières, Louis Guertin, Edith Filion, Apostolos Christopoulos, Louise Lambert, Mustapha Tehfe, Tareck Ayad, Danielle Charpentier, Rahima Jamal, Philip Wong

Open Access Research article

CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer

Andrea Rebeca Bustos-Carpinteyro, Carla Oliveira, Abel Sousa, Patricia Oliveira, Hugo Pinheiro, Joana Carvalho, María Teresa Magaña-Torres, María Guadalupe Flores-Miramontes, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Jorge Peregrina-Sandoval, José Alfonso Cruz-Ramos, Josefina Yoaly Sánchez-López

Open Access Research article

Long term follow-up of neoadjuvant chemotherapy for non-small cell lung cancer (NSCLC) investigating early positron emission tomography (PET) scan as a predictor of outcome

Perrin E. Romine, Renato G. Martins, Keith D. Eaton, Douglas E. Wood, Fatemeh Behnia, Bernardo H. L. Goulart, Michael S. Mulligan, Sarah G. Wallace, Elizabeth Kell, Julie E. Bauman, Shilpen A. Patel, Hubert J. Vesselle

Open Access Research article

Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević, Tatjana Stanojković

Open Access Research article

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Benjamin Goeppert

Open Access Research article

Serum Hepcidin and GDF-15 levels as prognostic markers in urothelial carcinoma of the upper urinary tract and renal cell carcinoma

Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader, Andrea U. Steinbicker

Open Access Research article

CD1d- and PJA2-related immune microenvironment differs between invasive breast carcinomas with and without a micropapillary feature

Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi, Takuya Moriya

Open Access Research article

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

Zehui Li, Nneka E. Mbah, Jean H. Overmeyer, Jeffrey G. Sarver, Sage George, Christopher J. Trabbic, Paul W. Erhardt, William A. Maltese

Open Access Research article

Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson, Kiven Erique Lukong

Open Access Research article

Different prognostic implication of ypTNM stage and pTNM stage for gastric cancer: a propensity score-matched analysis

Ziyu Li, Yinkui Wang, Xiangji Ying, Fei Shan, Zhouqiao Wu, Lianhai Zhang, Shuangxi Li, Yongning Jia, Hui Ren, Jiafu Ji

Open Access Research article

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients

Vu Luan Dang Chi, Soizic Garaud, Pushpamali De Silva, Vincent Thibaud, Basile Stamatopoulos, Mimoune Berehad, Chunyan Gu-Trantien, Mohammad Krayem, Hugues Duvillier, Jean-Nicolas Lodewyckx, Karen Willard-Gallo, Catherine Sibille, Dominique Bron

Open Access Research article

Cancer-related concerns and needs among young adults and children on cancer treatment in Tanzania: a qualitative study

Thecla W. Kohi, Louise von Essen, Golden M. Masika, Maria Gottvall, Justine Dol

Open Access Research article

Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome

Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan, Adam A. Sabile

Open Access Research article

Does guideline non-adherence result in worse clinical outcomes for hormone receptor-positive and HER2-negative metastatic breast cancer in premenopausal women?: result of an institution database from South Korea

Hee Kyung Kim, Soo-Hyeon Lee, Yu Jin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu, Yeon Hee Park

Open Access Research article

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors

Ari Meerson, Yaniv Eliraz, Hila Yehuda, Bridget Knight, Malcolm Crundwell, Douglas Ferguson, Benjamin P. Lee, Lorna W. Harries

Open Access Research article

Epidemiological characteristics, clinical outcomes and management patterns of metastatic breast cancer patients in routine clinical care settings of Greece: Results from the EMERGE multicenter retrospective chart review study

Athanasios Kotsakis, Alexandros Ardavanis, Georgios Koumakis, Epameinondas Samantas, Amanta Psyrri, Christos Papadimitriou

Open Access Study protocol

A randomized controlled trial of a group acceptance-based intervention for cancer survivors experiencing anxiety at re-entry (‘Valued Living’): study protocol

Joanna J. Arch, Jill L. Mitchell, Sarah R. Genung, Robert Fisher, David J. Andorsky, Annette L. Stanton

Open Access Research article

Does the number of removed axillary lymphnodes in high risk breast cancer patients influence the survival?

Florian Ebner, Achim Wöckel, Lukas Schwentner, Maria Blettner, Wolfgang Janni, Rolf Kreienberg, Manfred Wischnewsky

Open Access Research article

Identifying optimal candidates for local treatment of the primary tumor among patients with de novo metastatic nasopharyngeal carcinoma: a retrospective cohort study based on Epstein–Barr virus DNA level and tumor response to palliative chemotherapy

Xue-Song Sun, Li-Ting Liu, Sai-Lan Liu, Shan-Shan Guo, Yue-Feng Wen, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Jun Ma, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai

Open Access Research article

Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

Daniel Castellano-Castillo, Sonsoles Morcillo, Ana B. Crujeiras, Lidia Sánchez-Alcoholado, Mercedes Clemente-Postigo, Esperanza Torres, Francisco José Tinahones, Manuel Macias-Gonzalez

Open Access Research article

Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice

Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma, Jian Lu

Open Access Research article

Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis

Xin Yin, Danfang Yan, Miao Qiu, Liming Huang, Sen-Xiang Yan

Open Access Research article

CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer

Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang, Yuan Yuan

Open Access Correction

Correction to: Randomized prospective phase III trial of 68Ga-PSMA-11 PET/CT molecular imaging for prostate cancer salvage radiotherapy planning [PSMA-SRT]

Jeremie Calais, Johannes Czernin, Wolfgang P. Fendler, David Elashoff, Nicholas G. Nickols

Open Access Study protocol

Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation

Stefanus van Rooijen, Francesco Carli, Susanne Dalton, Gwendolyn Thomas, Rasmus Bojesen, Morgan Le Guen, Nicolas Barizien, Rashami Awasthi, Enrico Minnella, Sandra Beijer, Graciela Martínez-Palli, Rianne van Lieshout, Ismayil Gögenur, Carlo Feo, Christoffer Johansen, Celena Scheede-Bergdahl, Rudi Roumen, Goof Schep, Gerrit Slooter

Open Access Research article

Effect of topical microporous polysaccharide hemospheres on the duration and amount of fluid drainage following mastectomy: a prospective randomized clinical trial

Lorena P. Suarez-Kelly, W. Hampton Pasley, Eric J. Clayton, Stephen P. Povoski, William E. Carson, Ray Rudolph

Open Access Research article

A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma

M. R. Zuo, R. F. Liang, M. Li, Y. F. Xiang, S. X. Zhang, Y. Yang, X. Wang, Q. Mao, Y. H. Liu

Open Access Correction

Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen

Open Access Research article

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan

Open Access Research article

Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection

Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang, David L. Adelson

Open Access Research article

Impact on prognosis of rebiopsy in advanced non-small cell lung cancer patients after epidermal growth factor receptor-tyrosine kinase inhibitor treatment: a systematic review

Takuma Imakita, Hirotaka Matsumoto, Katsuya Hirano, Toshiyuki Morisawa, Azusa Sakurai, Yuki Kataoka

Open Access Research article

Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples

Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman, Natarajan Aravindan

Open Access Research article

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid, Fabian D. Mairinger

Open Access Research article

Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia

Yao Xue, Yuqiu Ge, Meiyun Kang, Cong Wu, Yaping Wang, Liucheng Rong, Yongjun Fang

Open Access Research article

The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases

Amélie Darlix, Christophe Hirtz, Simon Thezenas, Aleksandra Maceski, Audrey Gabelle, Evelyne Lopez-Crapez, Hélène De Forges, Nelly Firmin, Séverine Guiu, William Jacot, Sylvain Lehmann

Open Access Research article

Human papillomavirus genotype distribution and socio-behavioural characteristics in women with cervical pre-cancer and cancer at the start of a human papillomavirus vaccination programme: the CIN3+ plus study

Dianne Egli-Gany, Anne Spaar Zographos, Joachim Diebold, Virginie Masserey Spicher, Brigitte Frey Tirri, Rolf Heusser, Joakim Dillner, Patrick Petignat, Roland Sahli, Nicola Low, Astrid Baege, Fridolin Bannwart, Clauldia Berlin, Pascal Cassinotti, Gieri Cathomas, Johanna Claass, Carina Eklund, Milo Frattini, Anne Graber, Anina Häfliger, Liza Ho, Andre Kind, Christian Kreis, Luca Mazzucchelli, Thomas McKee, Eric Megevand, Ulrike Meyer-Hamme, Francesca Molinari, Christoph Noppen, Aurelia Noske, Ines Raineri, Elisabetta Rapiti, Dominique Rubi, Niels J. Rupp, Kathrin Schwedler, Thomas Stallmach, Jean-Christophe Tille, Luigi Tornillo, Alexandra Valera, Dominique Weintraub, Philip Went, Dieter Zimmermann

Open Access Research article

MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy

Jing Ye, Xiao-dong Cheng, Bei Cheng, Yi-fan Cheng, Xiao-Jing Chen, Wei-guo Lu

Open Access Research article

Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Ersilia Lucenteforte, Alfredo Vannacci, Giada Crescioli, Niccolò Lombardi, Laura Vagnoli, Laura Giunti, Valentina Cetica, Maria Luisa Coniglio, Alessandra Pugi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Roberto Barale, Lisa Giovannelli, Alessandro Mugelli, Valentina Maggini

Open Access Research article

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients

Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida

Open Access Research article

Predictors for use of psychosocial services in patients with metastatic colorectal cancer receiving first line systemic treatment

Claudia S. E. W. Schuurhuizen, Annemarie M. J. Braamse, Inge R. H. M. Konings, Henk M. W. Verheul, Joost Dekker

Open Access Case report

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature

Taketsugu Fujibuchi, Joji Miyawaki, Teruki Kidani, Hiroshi Imai, Hiroshi Kiyomatsu, Riko Kitazawa, Hiromasa Miura

Open Access Research article

Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme

Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland

Open Access Research article

Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population

Lenny N. Gallardo-Alvarado, María Teresa Tusié-Luna, María Isabel Tussié-Luna, José Díaz-Chávez, Yayoi X. Segura, Enrique Bargallo-Rocha, Cynthia Villarreal, Luis A. Herrera-Montalvo, Enrique M. Herrera-Medina, David F. Cantu-de Leon

Open Access Research article

Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

Lisa König, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer, Agnes Bankfalvi

Open Access Study protocol

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)

Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy Maughan, Somnath Mukherjee

Open Access Research article

Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy

Zsuzsanna Kahan, Daniela Grecea, Martin Smakal, Sergei Tjulandin, Igor Bondarenko, Luca Perjesi, Andras Illes, Karoly Horvat-Karajz, Ildiko Aradi

Open Access Research article

Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis

Zhao-Wen Luo, Ming-Gu Zhu, Zhi-Qiao Zhang, Feng-Jun Ye, Wen-Heng Huang, Xue-Zhang Luo

Open Access Correction

Correction to: Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy

Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini, Charles-Henry Rochat

Open Access Research article

Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial

Mami Ogita, Kenji Sekiguchi, Keiko Akahane, Ryoko Ito, Chiori Haga, Satoru Arai, Yasushi Ishida, Jiro Kawamori

Open Access Research article

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini

Open Access Research article

Tumor classification and biomarker discovery based on the 5’isomiR expression level

Shengqin Wang, Zhihong Zheng, Peichao Chen, Mingjiang Wu

Open Access Research article

Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model

Lu Wang, Liyuan Liu, Zhen Lou, Lijie Ding, Hui Guan, Fei Wang, Lixiang Yu, Yujuan Xiang, Fei Zhou, Fuzhong Xue, Zhigang Yu

Open Access Research article

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs

Hong Liu, Pei-wu Li, Wei-qin Yang, Hong Mi, Jing-lin Pan, Yuan-cheng Huang, Zheng-kun Hou, Qiu-ke Hou, Qi Luo, Feng-bin Liu

Open Access Research article

Breaking silence: a survey of barriers to goals of care discussions from the perspective of oncology practitioners

Katrina Lynn Piggott, Ameen Patel, Arthur Wong, Leslie Martin, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind, John J. You

Open Access Research article

Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

Alex Molassiotis, Hui Lin Cheng, Violeta Lopez, Joseph S. K. Au, Alexandre Chan, Aishwarya Bandla, K. T. Leung, Y. C. Li, K. H. Wong, Lorna K. P. Suen, Choi Wan Chan, Janelle Yorke, Carole Farrell, Raghav Sundar

Open Access Research article

A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas, Yildiz E. Yilmaz

Open Access Research article

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials

Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Amélie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Marianne Paesmans, Alain Hendlisz

Open Access Research article

Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy

Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad, Mohamed Al Bashir

Open Access Research article

Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells

Olga D’Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne

Open Access Research article

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot, Stéphane Bolduc

Open Access Research article

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis

Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T. Y. Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong, Paul K. S. Chan

Open Access Research article

Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study

Charles A. Stiller, Anita M. Bayne, Aruna Chakrabarty, Tom Kenny, Paul Chumas

Open Access Research article

Cost-effectiveness of bevacizumab plus paclitaxel versus paclitaxel for the first-line treatment of HER2-negative metastatic breast cancer in specialist oncology centers in France

Audrey Petitjean, Jayne Smith-Palmer, William Valentine, Bertrand Tehard, Stephané Roze

Open Access Research article

Hematologic markers of distant metastases and poor prognosis in gynecological cancers

O. Abu-Shawer, M. Abu-Shawer, N. Hirmas, A. Alhouri, A. Massad, B. Alsibai, H. Sultan, H. Hammo, M. Souleiman, Y. Shebli, M. Al-Hussaini

Open Access Research article

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt, Torben F. Hansen

Open Access Research article

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases

Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang, Xiaohua Liang

Open Access Research article

Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus

Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng, Jianzhong Shou

Open Access Research article

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis

Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao

Open Access Research article

Sleep disorders associated with risk of prostate cancer: a population-based cohort study

Wei-Sheng Chung, Cheng-Li Lin

Open Access Research article

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up

Yang Guang, Wen He, Yukun Luo, Hongxia Zhang, Yukang Zhang, Bin Ning, Tengfei Yu

Open Access Research article

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim

Open Access Research article

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Young-Cheol Lim, Hyeongi Kim, Sang Moo Lim, Jin Su Kim

Open Access Research article

Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study

Omar F. Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J. Ko, Haocheng Li, Aalok Kumar, Michael M. Vickers, Patricia A. Tang

Open Access Research article

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice

Derek Weycker, Mark Hatfield, Aaron Grossman, Ahuva Hanau, Alex Lonshteyn, Anjali Sharma, David Chandler

Open Access Correction

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study

Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart, Max J. Henderson

Open Access Research article

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells

Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro, Wenyi Gu

Open Access Research article

Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center

Nooria Atta, Saadettin Kilickap, Deniz Yuce, Mutlu Hayran

Open Access Research article

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients

Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert, Matthias Kappler

Open Access Research article

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients

Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshiaki Kawamura, Yuki Shimizu, Toshiro Terachi, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda, Yusuke Yamada, Shingo Yamamoto, Hiromi Hirama, Mikio Sugimoto, Yoshiyuki Kakehi, Toshihiko Sakurai, Norihiko Tsuchiya

Open Access Research article

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton, Sebastian G. B. Furness

Open Access Research article

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro

Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha, Patrick E. Chappell

Open Access Research article

Stromal cell ratio based on automated image analysis as a predictor for platinum-resistant recurrent ovarian cancer

C. Lan, J. Li, X. Huang, A. Heindl, Y. Wang, S. Yan, Y. Yuan

Open Access Research article

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer

Elisabeth C. W. Neefjes, Maurice J. D. L. van der Vorst, Manon S. A. Boddaert, Bea A. T. T. Verdegaal, Aart Beeker, Saskia C. C. Teunissen, Aartjan T. F. Beekman, Wouter W. A. Zuurmond, Johannes Berkhof, Henk M. W. Verheul

Open Access Research article

Efficacy and risk of cytotoxic chemotherapy in extensive disease-small cell lung cancer patients with interstitial pneumonia

Masayuki Shirasawa, Tomoya Fukui, Seiichiro Kusuhara, Yasuhiro Hiyoshi, Yoshiro Nakahara, Noriko Nishinarita, Satoshi Igawa, Katsuhiko Naoki

Open Access Research article

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review

Yingying Mao, Wenjun Yang, Qi Qi, Fei Yu, Tianpei Wang, Hongfei Zhang, Juncheng Dai, Hongxia Ma, Zhibin Hu, Hongbing Shen, Gang Li, Guangfu Jin

Open Access Research article

Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy

Milana Bergamino, Antonio J. Rullan, Maria Saigí, Inmaculada Peiró, Eduard Montanya, Ramón Palmero, José Carlos Ruffinelli, Arturo Navarro, María Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Felipe Cardenal, Ernest Nadal

Open Access Research article

Are rare cancer survivors at elevated risk of subsequent new cancers?

Dianne M. Finkelstein, Nora K. Horick, Ritesh Ramchandani, Kristina L. Boyd, Huma Q. Rana, Brittany L. Bychkovsky

Open Access Study protocol

Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging

Anne Laprie, Soléakhéna Ken, Thomas Filleron, Vincent Lubrano, Laure Vieillevigne, Fatima Tensaouti, Isabelle Catalaa, Sergio Boetto, Jonathan Khalifa, Justine Attal, Guillaume Peyraga, Carlos Gomez-Roca, Emmanuelle Uro-Coste, Georges Noel, Gilles Truc, Marie-Pierre Sunyach, Nicolas Magné, Marie Charissoux, Stéphane Supiot, Valérie Bernier, Muriel Mounier, Muriel Poublanc, Amandine Fabre, Jean-Pierre Delord, Elizabeth Cohen-Jonathan Moyal

Open Access Research article

Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection

Aldrick Ruiz, Mylène Sebagh, Raphaël Saffroy, Marc-Antoine Allard, Nelly Bosselut, Giulia Hardoin, Julie Vasseur, Jocelyne Hamelin, René Adam, Jean-François Morère, Antoinette Lemoine

Open Access Case report

BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review

Mohammad A. Al Hamad, Hassan M. Albisher, Weam R. Al Saeed, Ahmed T. Almumtin, Fatimah M. Allabbad, Mohammed A. Shawarby

Open Access Case report

Diffuse cavernous hemangioma of the skull misdiagnosed as skull metastasis in breast cancer patient: one case report and literature review

Huizhi Liu, Xiaojing Chang, Hua Shang, Feng Li, Huandi Zhou, Xiaoying Xue

Open Access Research article

The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Rainer J. Klement, N. Abbasi-Senger, S. Adebahr, H. Alheid, M. Allgaeuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, M. J. Eble, I. Ernst, S. Gerum, D. Habermehl, P. Hass, C. Henkenberens, G. Hildebrandt, D. Imhoff, H. Kahl, N. D. Klass, R. Krempien, V. Lewitzki, F. Lohaus, C. Ostheimer, A. Papachristofilou, C. Petersen, J. Rieber, T. Schneider, E. Schrade, R. Semrau, S. Wachter, A. Wittig, M. Guckenberger, N. Andratschke

Open Access Research article

Usefulness of hemoglobin A1c and glycated albumin measurements for insulinoma screening: an observational case-control study

Keiichi Torimoto, Yosuke Okada, Yoshiya Tanaka, Atsuko Matsuoka, Yushi Hirota, Wataru Ogawa, Yoshifumi Saisho, Isao Kurihara, Hiroshi Itoh, Shinya Inada, Masafumi Koga

Open Access Research article

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Kei Namba, Shuta Tomida, Takehiro Matsubara, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Takahiro Yoshioka, Tatsuaki Takeda, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka

Open Access Research article

Zoledronic acid blocks the interaction between breast cancer cells and regulatory T-cells

Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Tsun-Mei Lin

Open Access Research article

Appraising growth differentiation factor 15 as a promising biomarker in digestive system tumors: a meta-analysis

Yanqiu Wang, Tao Jiang, Mingyan Jiang, Shuijing Gu

Open Access Research article

Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia

Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley

Open Access Case report

Metachronous metastasis to inguinal lymph nodes from sigmoid colon adenocarcinoma with abdominal wall metastasis: a case report

Taro Tanabe, Dai Shida, Shunsuke Tsukamoto, Goki Morizono, Hirokazu Taniguchi, Yukihide Kanemitsu

Open Access Research article

IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study

Hong Ji, Le Lu, Jingjing Huang, Yang Liu, Binchao Zhang, Hui Tang, Dangze Sun, Yafei Zhang, Hao Shang, Yiming Li, Hongwei Lu

Open Access Case report

Primary paediatric epidural sarcomas: molecular exploration of three cases

Sharon Y. Y. Low, Chik Hong Kuick, Wan Yi Seow, Nurfahanah Bte Syed Sulaiman, Huiyi Chen, Derrick W. Q. Lian, Kenneth T. E. Chang, Enrica E. K. Tan, Shui Yen Soh, Grace I. L. Tan, Lee Ping Ng, Wan Tew Seow, David C. Y. Low

Open Access Research article

VEGFR2 promotes tumorigenesis and metastasis in a pro-angiogenic-independent way in gastric cancer

Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou, Min Jiang

Open Access Research article

A systematic review and meta-analysis of the prevalence of thrombosis and bleeding at diagnosis of Philadelphia-negative myeloproliferative neoplasms

Tarinee Rungjirajittranon, Weerapat Owattanapanich, Patompong Ungprasert, Noppadol Siritanaratkul, Theera Ruchutrakool

Open Access Review

Molecular Pathogenesis of Cholangiocarcinoma

Peter L. Labib, George Goodchild, Stephen P. Pereira

Open Access Case report

Pneumatosis intestinalis induced by osimertinib in a patient with lung adenocarcinoma harbouring epidermal growth factor receptor gene mutation with simultaneously detected exon 19 deletion and T790 M point mutation: a case report

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Open Access Research article

The prognostic relevance of FOXA1 and Nestin expression in breast cancer metastases: a retrospective study of 164 cases during a 10-year period (2004–2014)

Shahin De Lara, Jenny Nyqvist, Elisabeth Werner Rönnerman, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z. Parris, Anikó Kovács

Open Access Correction

Correction to: miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas

Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li, Juanjuan Xiang

Open Access Research article

The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database

Sarah Hummel, Wendy Kohlmann, Thomas M. Kollmeyer, Robert Jenkins, Joshua Sonnen, Cheryl A. Palmer, Howard Colman, Diana Abbott, Lisa Cannon-Albright, Adam L. Cohen

Open Access Case report

Diagnosis and treatment complications of primary cardiac lymphoma in an immunocompetent 28-year old man: a case report

Maria Bonou, Chris J. Kapelios, Athanasios Marinakos, Stamatis Adamopoulos, Panagiotis Diamantopoulos, Periklis G. Foukas, Loukas Kaklamanis, Penelope Korkolopoulou, John Barbetseas, Nora-Athina Viniou

Open Access Case report

Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas

Anne-Katrin Hickmann, Maximilian Frick, Dirk Hadaschik, Florian Battke, Markus Bittl, Oliver Ganslandt, Saskia Biskup, Dennis Döcker

Open Access Research article

Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer

Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter, Stefan Steurer

Open Access Research article

The heart’s exposure to radiation increases the risk of cardiac toxicity after chemoradiotherapy for superficial esophageal cancer: a retrospective cohort study

Yoshito Hayashi, Hideki Iijima, Fumiaki Isohashi, Yoshiki Tsujii, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Tomoki Makino, Makoto Yamasaki, Kazuhiko Ogawa, Yuichiro Doki, Tetsuo Takehara

Open Access Research article

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer

Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Bhumsuk Keam

Open Access Research article

Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy

Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas, Jaunius Urbonavičius

Open Access Study protocol

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol

Paul Lesueur, Justine Lequesne, Jean-Michel Grellard, Audrey Dugué, Elodie Coquan, Pierre-Emmanuel Brachet, Julien Geffrelot, William Kao, Evelyne Emery, David Hassanein Berro, Laurent Castera, Nicolas Goardon, Joëlle Lacroix, Marie Lange, Aurélie Capel, Alexandra Leconte, Benoit Andre, Angélique Léger, Anaïs Lelaidier, Bénédicte Clarisse, Dinu Stefan

Open Access Research article

The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women

Sushmita Katuwal, Juha S. Tapanainen, Eero Pukkala, Antti Kauppila

Open Access Research article

The neoepitope landscape of breast cancer: implications for immunotherapy

Pooja Narang, Meixuan Chen, Amit A. Sharma, Karen S. Anderson, Melissa A. Wilson

Open Access Research article

The imbalance in the complement system and its possible physiological mechanisms in patients with lung cancer

Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou, Muying Ying

Open Access Research article

Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia

Anna Richter, Catrin Roolf, Mohamed Hamed, Yvonne Saara Gladbach, Sina Sender, Christoph Konkolefski, Gudrun Knübel, Anett Sekora, Georg Fuellen, Brigitte Vollmar, Hugo Murua Escobar, Christian Junghanss

Open Access Review

Challenges of driving CD30-directed CAR-T cells to the clinic

Natalie S. Grover, Barbara Savoldo

Open Access Research article

PPARγ activation serves as therapeutic strategy against bladder cancer via inhibiting PI3K-Akt signaling pathway

Shidong Lv, Wei Wang, Hongyi Wang, Yongtong Zhu, Chengyong Lei

Open Access Research article

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model

Margarite D. Matossian, Hope E. Burks, Steven Elliott, Van T. Hoang, Annie C. Bowles, Rachel A. Sabol, Bahia Wahba, Muralidharan Anbalagan, Brian Rowan, Mohamed E. Abazeed, Bruce A. Bunnell, Krzysztof Moroz, Lucio Miele, Lyndsay V. Rhodes, Steven D. Jones, Elizabeth C. Martin, Bridgette M. Collins-Burow, Matthew E. Burow

Open Access Study protocol

A multi-center prospective randomized controlled trial (phase III) comparing the quality of life between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy for gastric Cancer (study protocol)

Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae-Seok Min, Ye Seob Jee, Oh. Jeong, Hyundong Chae, Sung Il Choi, Hua Huang, Sungsoo Park

Open Access Research article

Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma

Annika Krückel, Alvaro Moreira, Waltraud Fröhlich, Gerold Schuler, Lucie Heinzerling

Open Access Research article

Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Meng Sha, Seogsong Jeong, Xin Wang, Ying Tong, Jie Cao, Han-Yong Sun, Lei Xia, Ning Xu, Zhi-Feng Xi, Jian-Jun Zhang, Xiao-Ni Kong, Qiang Xia

Open Access Research article

MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway

Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang, Guolong Liu

Open Access Research article

Development and validation of case-finding algorithms for recurrence of breast cancer using routinely collected administrative data

Yuan Xu, Shiying Kong, Winson Y. Cheung, Antoine Bouchard-Fortier, Joseph C. Dort, Hude Quan, Elizabeth M. Buie, Geoff McKinnon, May Lynn Quan

Open Access Research article

Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy

B. M. Donida, G. Tomasello, M. Ghidini, F. Buffoli, M. Grassi, W. Liguigli, G. Maglietta, L. Pergola, M. Ratti, G. Sabadini, L. Toppo, M. Ungari, R. Passalacqua

Open Access Research article

High Beclin-1 and ARID1A expression corelates with poor survival and high recurrence in intrahepatic cholangiocarcinoma: a histopathological retrospective study

Chao Bi, Mei Liu, Weiqi Rong, Fan Wu, Yang Zhang, Shengtao Lin, Yunhe Liu, Jianxiong Wu, Liming Wang

Open Access Research article

Quantification of intrinsic subtype ambiguity in Luminal A breast cancer and its relationship to clinical outcomes

Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi, Peter H. Gann

Open Access Research article

Combination of lymphovascular invasion and the AJCC TNM staging system improves prediction of prognosis in N0 stage gastric cancer: results from a high-volume institution

Jun Lu, Yun Dai, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang

Open Access Research article

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Congcong Li, Qing Zhang, Siying Zhang, Ruifen Dong, Chenggong Sun, Chunping Qiu, Zhiwei Zhang, Xingsheng Yang, Beihua Kong

Open Access Research article

Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial

Erin L. Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe E. Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook

Open Access Research article

Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers

Bernardo P. de Almeida, Joana Dias Apolónio, Alexandra Binnie, Pedro Castelo-Branco

Open Access Research article

Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis

Arturo B. Ramirez, Raksha Bhat, Debashish Sahay, Carmine De Angelis, Hariprasad Thangavel, Sina Hedayatpour, Lacey E. Dobrolecki, Agostina Nardone, Mario Giuliano, Chandandeep Nagi, Mothaffar Rimawi, C. Kent Osborne, Michael T. Lewis, Jackie L. Stilwell, Eric P. Kaldjian, Rachel Schiff, Meghana V. Trivedi

Open Access Research article

A hybrid technique of intracavitary and interstitial brachytherapy for locally advanced cervical cancer: initial outcomes of a single-institute experience

Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato, Jun Itami

Open Access Research article

Expression of long non-coding RNAs (lncRNAs) has been dysregulated in non-small cell lung cancer tissues

Farbod Esfandi, Mohammad Taheri, Mir Davood Omrani, Mohammad Behgam Shadmehr, Shahram Arsang-Jang, Roshanak Shams, Soudeh Ghafouri-Fard

Open Access Research article

β2-microglobulin has a different regulatory molecular mechanism between ER+ and ER− breast cancer with HER2−

Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu, Xiaowen Lian

Open Access Research article

RETRACTED ARTICLE: 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells

Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao, Kai-qun Ren

Open Access Research article

The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells

Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han, Conghui Han

Open Access Research article

18F-FDG PET/CT-based metabolic metrics in recurrent tumors of ovarian clear cell carcinoma and their prognostic implications

Shuang Ye, Shuai Liu, Libing Xiang, Xiaohua Wu, Huijuan Yang

Open Access Research article

Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools

Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Tuotuo Gong, Demao Yao

Open Access Research article

Utilization of a breast cancer risk assessment tool by internal medicine residents in a primary care clinic: impact of an educational program

Siddhartha Yadav, Sarah Hartkop, Paola Yumpo Cardenas, Rand Ladkany, Alexandra Halalau, Sandor Shoichet, Michael Maddens, Dana Zakalik

Open Access Research article

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks

Open Access Research article

Prognostic models for breast cancer: a systematic review

Minh Tung Phung, Sandar Tin Tin, J. Mark Elwood

Open Access Study protocol

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)

Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert, Nicolai Haertel

Open Access Research article

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis

Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng, Claudio Luchini

Open Access Research article

RETRACTED ARTICLE: Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145

Hongyang Sui, Anfeng Lou, Zhisong Li, Jianjun Yang

Open Access Research article

Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors

Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed, Linda Stuhr

Open Access Case report

Malignant perivascular epithelioid cell tumor of the lung synchronous with a primary adenocarcinoma: one case report and review of the literature

Jikai Zhao, Haohua Teng, Ruiying Zhao, Wenjie Ding, Keke Yu, Lei Zhu, Jie Zhang, Yuchen Han

Open Access Research article

NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid, Niamh E. Buckley

Open Access Research article

TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer

Caiyun Gao, Hongyu Yao, Huimin Liu, Yanying Feng, Zhijun Yang

Open Access Research article

Nomogram based on homogeneous and heterogeneous associated factors for predicting bone metastases in patients with different histological types of lung cancer

Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P. Baklaushev, Xin Wang, Guowen Wang

Open Access Research article

Cancer burden in the Caribbean: an overview of the Martinique Cancer Registry profile

Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Audrey Pomier, Aimée Pierre-Louis, Mylène Vestris, Jean-Luc Novella, Moustapha Drame, Jonathan Macni, Patrick Escarmant

Open Access Research article

Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients

Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou, Qi Song

Open Access Research article

The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: a retrospective study

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa, Masaichi Ohira

Open Access Case report

Decitabine plus CLAG chemotherapy as a bridge to haploidentical transplantation in the setting of acute myeloid leukemia relapse after HLA-matched sibling transplantation: a case report

Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang, Guoqing Wei

Open Access Research article

The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines

Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte, Hagen S. Bachmann

Open Access Research article

Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules

Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto, Taisuke Mori

Open Access Research article

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort

Kazuki Sone, Tetsuya Oguri, Takehiro Uemura, Akira Takeuchi, Satoshi Fukuda, Osamu Takakuwa, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito, Akio Niimi

Open Access Research article

RETRACTED ARTICLE: Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression

Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui, Zhuo Chen

Open Access Research article

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter, Georgia Schäfer

Open Access Research article

Analytical validation of CanAssist-Breast: an immunohistochemistry based prognostic test for hormone receptor positive breast cancer patients

Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar, Manjiri M. Bakre

Open Access Research article

Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

Ming-Wei Lai, Yu-De Chu, Chih-Lang Lin, Rong-Nan Chien, Ta-Sen Yeh, Tai-Long Pan, Po-Yuan Ke, Kwang-Hui Lin, Chau-Ting Yeh

Open Access Research article

Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study

Myoung Hwa Kim, Dong Wook Kim, Seho Park, Joo Heung Kim, Ki Young Lee, Jisung Hwang, Young Chul Yoo

Open Access Research article

Decreased serum carbohydrate antigen 19–9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients

Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Kenichiro Uemura, Ken-ichi Okada, Ippei Matsumoto, Minako Nagai, Hiroaki Yanagimoto, Masanao Kurata, Takumi Fukumoto, Masamichi Mizuma, Hiroki Yamaue, Michiaki Unno

Open Access Research article

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas, Taosheng Chen

Open Access Study protocol

Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; the COLOPEC 2 randomized multicentre trial

Vivian P. Bastiaenen, Charlotte E. L. Klaver, Niels F. M. Kok, Johannes H. W. de Wilt, Ignace H. J. T. de Hingh, Arend G. J. Aalbers, Djamila Boerma, Andre J. A. Bremers, Jacobus W. A. Burger, Eino B. van Duyn, Pauline Evers, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Eva V. E. Madsen, Petur Snaebjornsson, Jurriaan B. Tuynman, Marinus J. Wiezer, Marcel G. W. Dijkgraaf, Jarmila D. W. van der Bilt, Pieter J. Tanis

Open Access Research article

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy

Kazuaki Harada, Wataru Okamoto, Sachiyo Mimaki, Yasuyuki Kawamoto, Hideaki Bando, Riu Yamashita, Satoshi Yuki, Takayuki Yoshino, Yoshito Komatsu, Atsushi Ohtsu, Naoya Sakamoto, Katsuya Tsuchihara

Open Access Research article

Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis

Khadiga Abdulrashid, Nour AlHussaini, Wifag Ahmed, Lukman Thalib

Open Access Correction

Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Chao Zhang, Wenting Ni, Aiyun Wang, Yin Lu, Shile Huang

Open Access Research article

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform

Andrew Riley, Victoria Green, Ramsah Cheah, Gordon McKenzie, Laszlo Karsai, James England, John Greenman

Open Access Research article

Molecular iodine exerts antineoplastic effects by diminishing proliferation and invasive potential and activating the immune response in mammary cancer xenografts

Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano, Carmen Aceves

Open Access Research article

Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He, Wei Jie

Open Access Research article

LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features

Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo, Yejun Wang

Open Access Research article

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study

Janet A. Parsons, Nicole R. Greenspan, Natalie A. Baker, Chris McKillop, Lisa K. Hicks, Olivia Chan

Open Access Research article

A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin

Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg, Lars Ekblad

Open Access Research article

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux, George S. Baillie

Open Access Research article

Malignant tumours in urban Ghana: evidence from the city of Kumasi

Yaw Ampem Amoako, Baffour Awuah, Rita Larsen-Reindorf, Fred Kwame Awittor, Gloria Kyem, Kwame Ofori-Boadu, Ernest Osei-Bonsu, Dennis Odai Laryea

Open Access Correction

Correction to: Axin gene methylation status correlates with radiosensitivity of lung cancer cells

Lian-He Yang, Yang Han, Guang Li, Hong-Tao Xu, Gui-Yang Jiang, Yuan Miao, Xiu-Peng Zhang, Huan-Yu Zhao, Zheng-Fan Xu, Maggie Stoecker, Endi Wang, Ke Xu, En-Hua Wang

Open Access Correction

Correction to: The imbalance in the complement system and its possible physiological mechanisms in patients with lung cancer

Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou, Muying Ying

Open Access Research article

Cardiovascular medication use and risks of colon cancer recurrences and additional cancer events: a cohort study

Erin J. A. Bowles, Onchee Yu, Rebecca Ziebell, Lu Chen, Denise M. Boudreau, Debra P. Ritzwoller, Rebecca A. Hubbard, Jennifer M. Boggs, Andrea N. Burnett-Hartman, Andrew Sterrett, Monica Fujii, Jessica Chubak

Open Access Research article

Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang

Open Access Research article

A preliminary trial examining a ‘real world’ approach for increasing physical activity among breast cancer survivors: findings from project MOVE

Cristina M. Caperchione, Catherine M. Sabiston, Sean Stolp, Joan L. Bottorff, Kristin L. Campbell, Neil D. Eves, Susan L. Ellard, Carolyn Gotay, Paul Sharp, Tanya Pullen, Kayla M. Fitzpatrick

Open Access Research article

Assessment of change in quality of life, carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome

Daniel M. Halperin, Lynn Huynh, Jennifer L. Beaumont, Beilei Cai, Rachel H. Bhak, Sahil Narkhede, Todor Totev, Mei S. Duh, Maureen P. Neary, David Cella

Open Access Study protocol

Comparing stereotactic ablative radiotherapy (SABR) versus re-trans-catheter arterial chemoembolization (re-TACE) for hepatocellular carcinoma patients who had incomplete response after initial TACE (TASABR): a randomized controlled trial

Liang-Cheng Chen, Wen-Yen Chiou, Hon-Yi Lin, Moon-Sing Lee, Yuan-Chen Lo, Li-Wen Huang, Chun-Ming Chang, Tsung-Hsing Hung, Chih-Wen Lin, Kuo-Chih Tseng, Dai-Wei Liu, Feng-Chun Hsu, Shih-Kai Hung

Open Access Research article

Efficacy of bevacizumab combined with erlotinib for advanced hepatocellular carcinoma: a single-arm meta-analysis based on prospective studies

Liyun He, Huan Deng, Jun Lei, Fengming Yi, Jine Li, Xiu De Fan, Yiping Wei, Jianjun Xu, Wenxiong Zhang

Open Access Case report

HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report

Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, Didier Peiffert, Agnès Leroux, Xavier Sastre-Garau

Open Access Research article

Case-control Indian buffet process identifies biomarkers of response to Codrituzumab

Melanie F. Pradier, Bernhard Reis, Lori Jukofsky, Francesca Milletti, Toshihiko Ohtomo, Fernando Perez-Cruz, Oscar Puig

Open Access Research article

First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng, Binghe Xu

Open Access Research article

First-line cetuximab versus bevacizumab for RAS and BRAF wild-type metastatic colorectal cancer: a systematic review and meta-analysis

Bobo Zheng, Xin Wang, Mingtian Wei, Quan Wang, Jiang Li, Liang Bi, Xiangbing Deng, Ziqiang Wang

Open Access Research article

Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models

Yi-Fen Chen, Chung-Ji Liu, Li-Han Lin, Chung-Hsien Chou, Li-Yin Yeh, Shu-Chun Lin, Kuo-Wei Chang

Open Access Research article

Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis

Juan Che, Yanlin Wang, Xiaolin Zhang, Jun Chen

Open Access Study protocol

Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial

Maria Di Bartolomeo, Monica Niger, Federica Morano, Salvatore Corallo, Maria Antista, Stefano Tamberi, Sara Lonardi, Samantha Di Donato, Rossana Berardi, Mario Scartozzi, Giovanni Gerardo Cardellino, Francesco Di Costanzo, Lorenza Rimassa, Alberto Gianluigi Luporini, Raffaella Longarini, Alberto Zaniboni, Alessandro Bertolini, Gianluca Tomasello, Graziella Pinotti, Giorgio Scagliotti, Giampaolo Tortora, Andrea Bonetti, Andrea Spallanzani, Giovanni Luca Frassineti, Davide Tassinari, Francesco Giuliani, Saverio Cinieri, Evaristo Maiello, Claudio Verusio, Sergio Bracarda, Vincenzo Catalano, Michele Basso, Libero Ciuffreda, Ferdinando De Vita, Hector Soto Parra, Lorenzo Fornaro, Marta Caporale, Filippo de Braud, Filippo Pietrantonio

Open Access Research article

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, Cornelis F. M. Sier, Wilma E. Mesker

Open Access Case report

A lung cancer patient with deep vein thrombosis:a case report and literature review

Yungu Chen, Yiu Sing Tsang, Xiaoxia Chou, Jiong Hu, Qing Xia

Open Access Research article

Late presentation of hepatitis B among patients with newly diagnosed hepatocellular carcinoma: a national cohort study

Dong Hyun Sinn, Danbee Kang, Minwoong Kang, Seung Woon Paik, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak

Open Access Study protocol

Age-adjusted high-dose chemotherapy and autologous stem cell transplant in elderly and fit primary CNS lymphoma patients

Elisabeth Schorb, Juergen Finke, Gabriele Ihorst, Benjamin Kasenda, Heidi Fricker, Gerald Illerhaus

Open Access Research article

The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma

Chang-Ying Guo, Qian Zhu, Fang-Fang Tou, Xiao-Ming Wen, Yu-Kang Kuang, Hao Hu

Open Access Study protocol

A prospective, single-arm, open-label, non-randomized, phase IIa trial of a nonavalent prophylactic HPV vaccine to assess immunogenicity of a prime and deferred-booster dosing schedule among 9–11 year-old girls and boys – clinical protocol

Yi Zeng, Anna-Barbara Moscicki, Vikrant V. Sahasrabuddhe, Francisco Garcia, Heide Woo, Chiu-Hsieh Hsu, Eva Szabo, Eileen Dimond, Susan Vanzzini, Angelica Mondragon, Valerie Butler, Hillary DeRose, H.-H. Sherry Chow

Open Access Study protocol

Systemic and tumor-directed therapy for oligometastatic prostate cancer: study protocol for a phase II trial for veterans with de novo oligometastatic disease

Neil R. Parikh, Claudia Huiza, Jill S. Patel, Sonny Tsai, Nathisha Kalpage, May Thein, Sage Pitcher, Steve P. Lee, Warren S. Inouye, Mark L. Jordan, Homayoon Sanati, Lida Jafari, Carol J. Bennett, Greg E. Gin, Amar U. Kishan, Robert E. Reiter, Michael Lewis, Ahmad Sadeghi, William J. Aronson, Isla P. Garraway, Matthew B. Rettig, Nicholas G. Nickols

Open Access Research article

Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib

Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park, Baek-Yeol Ryoo

Open Access Research article

Thyroid Cancer in Ecuador, a 16 years population-based analysis (2001–2016)

Jorge Salazar-Vega, Esteban Ortiz-Prado, Paola Solis-Pazmino, Lenin Gómez-Barreno, Katherine Simbaña-Rivera, Aquiles R. Henriquez-Trujillo, Juan P. Brito, Theofilos Toulkeridis, Marco Coral-Almeida

Open Access Research article

Multimodal multiphoton imaging for label-free monitoring of early gastric cancer

Lianhuang Li, Deyong Kang, Zicheng Huang, Zhenlin Zhan, Changyin Feng, Yongjian Zhou, Haohua Tu, Shuangmu Zhuo, Jianxin Chen

Open Access Research article

Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma

Andreja Gornjec, Srdjan Novakovic, Vida Stegel, Marko Hocevar, Ziva Pohar Marinsek, Barbara Gazic, Mateja Krajc, Erik Skof

Open Access Research article

LncRNA ENST00000539653 acts as an oncogenic factor via MAPK signalling in papillary thyroid cancer

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Sophie Cowman, Yuen Ngan Fan, Barry Pizer, Violaine Sée

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Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

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Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions

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Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

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Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

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Serum and cerebrospinal fluid Neudesin concentration and Neudesin Quotient as potential circulating biomarkers of a primary brain tumor

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Open Access Case report

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Open Access Case report

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Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls

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Open Access Study protocol

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Diagnostic accuracy of 13N-ammonia PET, 11C-methionine PET and 18F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma

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A specific gene expression signature for visceral organ metastasis in breast cancer

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Open Access Case report

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Open Access Study protocol

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Open Access Case report

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Relative efficacy of interventions in the treatment of second-line non-small cell lung cancer: a systematic review and network meta-analysis

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Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients

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Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy

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Open Access Research article

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Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow

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Open Access Correction

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study

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Open Access Research article

Intratumoral heterogeneity of EGFR-activating mutations in advanced NSCLC patients at the single-cell level

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Open Access Technical Advance

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Open Access Research article

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Open Access Case report

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Open Access Case report

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Open Access Technical advance

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Open Access Research article

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Open Access Correction

Correction to: Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

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Open Access Case report

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Open Access Research article

Clinicopathological characteristics and health care for Tibetan women with breast cancer: a cross-sectional survey

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Open Access Research article

Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

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Open Access Study protocol

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Daniel D’Almeida Preto, Mariana Toledo Baston, Camilla Centurion Geraige, Sarah Bertazzi Augusto, Marco Antonio de Oliveira, Augusto Elias Mamere, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Pedro Rafael Martins De Marchi, Bianca Sakamoto Ribeiro Paiva, Carlos Eduardo Paiva

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Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

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Katherine Antel, Carly Levetan, Zainab Mohamed, Vernon J Louw, Jenna Oosthuizen, Gary Maartens, Estelle Verburgh

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Does external beam radiation boost to pelvic lymph nodes improve outcomes in patients with locally advanced cervical cancer?

Caryn Wujanto, Bok Ai Choo, David Tan, Arunachalam Ilancheran, Joseph Ng, Jeffrey J. H. Low, Liang Shen, Johann Tang, Vicky Koh

Open Access Research article

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Open Access Research article

BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer

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Open Access Research article

Efficacy of an RNA-based multigene assay with core needle biopsy samples for risk evaluation in hormone-positive early breast cancer

Jeeyeon Lee, Eun Hye Lee, Ho Yong Park, Wan Wook Kim, Ryu Kyung Lee, Yee Soo Chae, Soo Jung Lee, Jee-Eun Kim, Byeong-il Kang, Jee Young Park, Ji-Young Park, Jin Hyang Jung

Open Access Study protocol

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul, Hans J. van der Vliet, Marinus J. Wiezer, Djamila Boerma, Emma C. E. Wassenaar, Maartje Los, Cornelis B. Hunting, Arend G. J. Aalbers, Niels F. M. Kok, Koert F. D. Kuhlmann, Henk Boot, Myriam Chalabi, Schelto Kruijff, Lukas B. Been, Robert J. van Ginkel, Derk Jan A. de Groot, Rudolf S. N. Fehrmann, Johannes H. W. de Wilt, Andreas J. A. Bremers, Philip R. de Reuver, Sandra A. Radema, Karin H. Herbschleb, Wilhelmina M. U. van Grevenstein, Arjen J. Witkamp, Miriam Koopman, Nadia Haj Mohammad, Eino B. van Duyn, Walter J. B. Mastboom, Leonie J. M. Mekenkamp, Joost Nederend, Max J. Lahaye, Petur Snaebjornsson, Cornelis Verhoef, Hanneke W. M. van Laarhoven, Aeilko H. Zwinderman, Jeanette M. Bouma, Onno Kranenburg, Iris van ‘t Erve, Remond J. A. Fijneman, Marcel G. W. Dijkgraaf, Patrick H. J. Hemmer, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. J. T. de Hingh

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Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer

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Open Access Research article

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Open Access Research article

Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv, Qingan Jia

Open Access Technical advance

Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples

Falk Zakrzewski, Laura Gieldon, Andreas Rump, Michael Seifert, Konrad Grützmann, Alexander Krüger, Sina Loos, Silke Zeugner, Karl Hackmann, Joseph Porrmann, Johannes Wagner, Karin Kast, Pauline Wimberger, Gustavo Baretton, Evelin Schröck, Daniela Aust, Barbara Klink

Open Access Study protocol

A multicenter phase III study comparing Simultaneous Integrated Boost (SIB) radiotherapy concurrent and consolidated with S-1 versus SIB alone in elderly patients with esophageal and esophagogastric cancer – the 3JECROG P-01 study protocol

Chen Li, Xiaomin Wang, Xin Wang, Chun Han, Ping Wang, Qingsong Pang, Junqiang Chen, Xinchen Sun, Lan Wang, Wencheng Zhang, Yu Lin, Xiaolin Ge, Zongmei Zhou, Wenjie Ni, Xiao Chang, Jun Liang, Lei Deng, Wenqing Wang, Yidian Zhao, Zefen Xiao

Open Access Research article

Plasma levels of M-CSF and VEGF in laboratory diagnostics and differentiation of selected histological types of cervical cancers

Iwona Sidorkiewicz, Monika Zbucka-Krętowska, Kamil Zaręba, Emilia Lubowicka, Monika Zajkowska, Maciej Szmitkowski, Ewa Gacuta, Sławomir Ławicki

Open Access Research article

The presence of bacteria varies between colorectal adenocarcinomas, precursor lesions and non-malignant tissue

Caspar Bundgaard-Nielsen, Ulrik T. Baandrup, Lars P. Nielsen, Suzette Sørensen

Open Access Research article

RETRACTED ARTICLE: Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway

Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen, Hongyu Yang

Open Access Research article

CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis

Anna Torres, Małgorzata Pac-Sosińska, Krzysztof Wiktor, Tomasz Paszkowski, Ryszard Maciejewski, Kamil Torres

Open Access Research article

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells

Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf, Mathias Hafner

Open Access Research article

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

Luka Opasic, Da Zhou, Benjamin Werner, David Dingli, Arne Traulsen

Open Access Study protocol

Local excision in mid-to-low rectal cancer patients who revealed clinically total or near-total regression after preoperative chemoradiotherapy; a proposed trial

Jong Lyul Lee, Seok-Byung Lim, Chang Sik Yu, In Ja Park, Yong Sik Yoon, Chan Wook Kim, Seong Ho Park, Jong Seok Lee, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jong Hoon Kim, Jin-hong Park, Jihun Kim, Minkyu Han

Open Access Research article

miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

Zhuo Liu, Feng He, Shengrong OuYang, Yuanyuan Li, Feifei Ma, Huibo Chang, Dingding Cao, Jianxin Wu

Open Access Research article

Ιmpact of sunitinib-induced hypothyroidism on survival of patients with metastatic renal cancer

Theofanis Vasileiadis, Michail Chrisofos, Michail Safioleas, Konstantinos Kontzoglou, Konstantinos Papazisis, Athina Sdrolia

Open Access Research article

The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy

Hang Sun, Hongxin Ding, Jianjun Wang, Emma Zhang, Yihua Fang, Zhenhua Li, Xiao Yu, Chongren Wang, Yifan Zhao, Kan Chen, Siwan Wen, Liang Li, Shan Shan, Liu Hong, Face Chen, Pu Su

Open Access Research article

Tumor Hypervascularity and hand-foot-skin reaction predict better outcomes in combination treatment of TACE and Sorafenib for intermediate hepatocellular carcinoma

Enxin Wang, Dongdong Xia, Wei Bai, Jie Yuan, Xiaomei Li, Jing Niu, Zhanxin Yin, Jielai Xia, Hongwei Cai, Daiming Fan, Guohong Han, Lei Liu

Open Access Case report

The increase in activating EGFR mutation in plasma is an early biomarker to monitor response to osimertinib: a case report

Marzia Del Re, Eleonora Rofi, Carla Cappelli, Gianfranco Puppo, Stefania Crucitta, Simona Valeggi, Antonio Chella, Romano Danesi, Iacopo Petrini

Open Access Research article

Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis

Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman, Félix Fernández-Madrid

Open Access Research article

Cytogenetic characterization of the malignant primitive neuroectodermal SK-PN-DW tumor cell line

Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu, Feng Wang

Open Access Study protocol

Neoadjuvant anti-programmed Death-1 immunotherapy by Pembrolizumab in resectable nodal positive stage II/IIIa non-small-cell lung cancer (NSCLC): the NEOMUN trial

Florian Eichhorn, Laura V. Klotz, Helge Bischoff, Michael Thomas, Felix Lasitschka, Hauke Winter, Hans Hoffmann, Martin E. Eichhorn

Open Access Study protocol

Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study

Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M. Nilsson, Jonas A. Nilsson, Lars Ny

Open Access Research article

Body weight loss after surgery affects the continuity of adjuvant chemotherapy for pancreatic cancer

Yoshifumi Morita, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yasushi Shibasaki, Hirotoshi Kikuchi, Hiroyuki Konno, Hiroya Takeuchi

Open Access Research article

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Xingyu Niu, Qigen Fang, Fei Liu

Open Access Research article

The association between post-treatment surveillance testing and survival in stage II and III colon cancer patients: An observational comparative effectiveness study

Robert B. Hines, Md Jibanul Haque Jiban, Adrian V. Specogna, Priya Vishnubhotla, Eunkyung Lee, Shunpu Zhang

Open Access Research article

microRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

Sunyoung Park, Jungho Kim, Kiyoon Eom, Sehee Oh, Sunghyun Kim, Geehyuk Kim, Sungwoo Ahn, Kwang Hwa Park, Dawn Chung, Hyeyoung Lee

Open Access Study protocol

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy versus palliative systemic chemotherapy in stomach cancer patients with peritoneal dissemination, the study protocol of a multicentre randomised controlled trial (PERISCOPE II)

W. J. Koemans, R. T. van der Kaaij, H. Boot, T. Buffart, A. A. F. A. Veenhof, K. J. Hartemink, C. Grootscholten, P. Snaebjornsson, V. P. Retel, H. van Tinteren, S. Vanhoutvin, V. van der Noort, A. Houwink, C. Hahn, A. D. R. Huitema, M. Lahaye, M. Los, P. van den Barselaar, O. Imhof, A. Aalbers, G. M. van Dam, B. van Etten, B. P. L. Wijnhoven, M. D. P. Luyer, D. Boerma, J. W. van Sandick

Open Access Research article

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy

Dae-Won Lee, Sae-Won Han, Yongjun Cha, Jeong Mo Bae, Hwang-Phill Kim, Jaemyun Lyu, Hyojun Han, Hyoki Kim, Hoon Jang, Duhee Bang, Jae-Kyung Won, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim

Open Access Research article

Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

Alexandre A. B. A. da Costa, Luisa M. do Canto, Simon Jonas Larsen, Adriana Regina Gonçalves Ribeiro, Carlos Eduardo Stecca, Annabeth Høgh Petersen, Mads M. Aagaard, Louise de Brot, Jan Baumbach, Glauco Baiocchi, Maria Isabel Achatz, Silvia Regina Rogatto

Open Access Research article

A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer

Constantin Georgescu, Joshua M. Corbin, Sandra Thibivilliers, Zachary D. Webb, Yan D. Zhao, Jan Koster, Kar-Ming Fung, Adam S. Asch, Jonathan D. Wren, Maria J. Ruiz-Echevarría

Open Access Technical advance

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de Sande, Wouter Willaert, Sarah Cosyns, Kaat De Clercq, Molood Shariati, Katrien Remaut, Wim Ceelen

Open Access Research article

Health-related quality of life and utility in head and neck cancer survivors

Li-Jen Liao, Wan-Lun Hsu, Wu-Chia Lo, Po-Wen Cheng, Pei-Wei Shueng, Chen-Hsi Hsieh

Open Access Research article

The healthcare costs of treating human papillomavirus-related cancers in Norway

Hannah Hylin, Helene Thrane, Kine Pedersen, Ivar S. Kristiansen, Emily A. Burger

Open Access Research article

Blood serum proteins as biomarkers for prediction of survival, locoregional control and distant metastasis rate in radiotherapy and radio-chemotherapy for non-small cell lung cancer

Rafał Suwinski, Monika Giglok, Katarzyna Galwas-Kliber, Adam Idasiak, Bozena Jochymek, Regina Deja, Barbara Maslyk, Jolanta Mrochem-Kwarciak, Dorota Butkiewicz

Open Access Research article

Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development

Sandra P. Prieto, Cassandra L. Reed, Haley M. James, Kyle P. Quinn, Timothy J. Muldoon

Open Access Research article

Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

A. Hendricks, F. Gieseler, S. Nazzal, J. H. Bräsen, R. Lucius, B. Sipos, J. H. Claasen, Th. Becker, S. Hinz, G. Burmeister, C. Schafmayer, C. Schrader

Open Access Study protocol

Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study

Frederic Bludau, Grit Welzel, Tina Reis, Yasser Abo-Madyan, Elena Sperk, Frank Schneider, Sven Clausen, Arne M. Ruder, Udo Obertacke, Maged M. Ghaly, Frederik Wenz, Frank A. Giordano

Open Access Research article

Prognostic impact of tumor location in colon cancer: the Monitoring of Cancer Incidence in Japan (MCIJ) project

Hiroko Nakagawa-Senda, Megumi Hori, Tomohiro Matsuda, Hidemi Ito

Open Access Research article

Downstaging in opportunistic breast cancer screening in Brazil: a temporal trend analysis

Diama Bhadra Vale, Cassio Cardoso Filho, Julia Yoriko Shinzato, Fernanda Servidoni Spreafico, Partha Basu, Luiz Carlos Zeferino

Open Access Research article

AVAiLABLE NIS – AVASTIN® in lung cancer treatment in routine oncology practice in Germany

Mark-Oliver Zahn, Dominik Linck, Christoph Losem, Christian Gessner, Holger Metze, Vincent E. Gaillard, Hans Werner Tessen

Open Access Research article

Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation

Kseniia Cheloshkina, Maria Poptsova

Open Access Research article

Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability

Bernt Popp, Abbas Agaimy, Cornelia Kraus, Karl X. Knaup, Arif B. Ekici, Steffen Uebe, André Reis, Michael Wiesener, Christiane Zweier

Open Access Research article

Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer

Peter McAnena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown, Michael J. Kerin

Open Access Research article

Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells

Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che, Eiichi Gohda

Open Access Research article

Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles

S. Visser, J. Hou, K. Bezemer, L. L. de Vogel, J. P. J. J. Hegmans, B. H. Stricker, S. Philipsen, J. G. J. V. Aerts

Open Access Research article

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang, Shiguang Zhao

Open Access Research article

Everolimus in hormone receptor-positive metastatic breast cancer: PIK3CA mutation H1047R was a potential efficacy biomarker in a retrospective study

Zongbi Yi, Fei Ma, Binliang Liu, Xiuwen Guan, Lixi Li, Chunxiao Li, Haili Qian, Binghe Xu

Open Access Research article

Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors

Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Valérie Lemay, Laurence Bertout, Caroline Laverdiere, Gregor Andelfinger, Maja Krajinovic, Daniel Sinnett, Daniel Curnier

Open Access Research article

Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer

Fei Zhao, Fu-Xi Zhen, Yue Zhou, Chen-Jun Huang, Yue Yu, Jun Li, Qi-Fan Li, Cheng-Xiang Zhu, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Liang Chen, Wei Wang

Open Access Research article

Role of delayed salvage bevacizumab at symptomatic progression of chemorefractory glioblastoma

Moire Cuncannon, Matthew Wong, Dasantha Jayamanne, Linxin Guo, Nicola Cove, Helen Wheeler, Michael Back

Open Access Research article

Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

Kai Wang, Guanying Wang, Shangke Huang, Anqi Luo, Xin Jing, Gang Li, Yi Zhou, Xinhan Zhao

Open Access Research article

Resilience and associated factors among Chinese patients diagnosed with oral cancer

Yuqin Gao, Lulu Yuan, Bochen Pan, Lie Wang

Open Access Research article

High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer

Zaiping Chen, Guiyang Wu, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Xiongwen Zhu, Chongshan Wu

Open Access Case report

Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review

Karam Khaddour, Veerpal Singh, Maryna Shayuk

Open Access Research article

The role of mSEPT9 in screening, diagnosis, and recurrence monitoring of colorectal cancer

Jie Sun, Fei Fei, Mingqing Zhang, Yuwei Li, Xipeng Zhang, Siwei Zhu, Shiwu Zhang

Open Access Research article

Clinical implications of a novel prognostic factor AIFM3 in breast cancer patients

Ang Zheng, Lin Zhang, Xinyue Song, Yuying Wang, Minjie Wei, Feng Jin

Open Access Research article

High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma

Maria Cristina Curia, Fabiana Fantini, Rossano Lattanzio, Francesca Tavano, Francesco Di Mola, Mauro Piantelli, Pasquale Battista, Pierluigi Di Sebastiano, Alessandro Cama

Open Access Research article

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Cecilia Martínez-Campos, Kirvis Torres-Poveda, Margarita Camorlinga-Ponce, Lourdes Flores-Luna, Carmen Maldonado-Bernal, Vicente Madrid-Marina, Javier Torres

Open Access Research article

Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway

Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben, Qi Chen

Open Access Research article

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii

Open Access Review

Portrait of a cancer: mutational signature analyses for cancer diagnostics

Arne Van Hoeck, Niels H. Tjoonk, Ruben van Boxtel, Edwin Cuppen

Open Access Research article

Longitudinal evaluation of Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK), a symptom screening and management application

Emily Vettese, Sadie Cook, Dilip Soman, Susan Kuczynski, Brenda Spiegler, Hailey Davis, Nathan Duong, Tal Schechter, L. Lee Dupuis, Lillian Sung

Open Access Case report

Long-term survival of an elderly patient with advanced gastric cancer after combination therapy: a case report and literature review

Qingwei Li, Xuejun Xu, Dan Su, Tianshuo Zhou, Guangyu Wang, Zhiwei Li

Open Access Research article

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Feng Wang, Ming-Ming He, Zi-Xian Wang, Su Li, Ying Jin, Chao Ren, Si-Mei Shi, Bing-Tian Bi, Shuang-Zhen Chen, Zhi-Da Lv, Jia-Jia Hu, Zhi-Qiang Wang, Feng-Hua Wang, De-Shen Wang, Yu-Hong Li, Rui-Hua Xu

Open Access Research article

Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: a nationwide cohort study

Chien-Liang Lin, Shang-Yin Wu, Wen-Tsung Huang, Yin-Hsun Feng, Ching-Yi Yiu, Wei-Fan Chiang, Sheng-Yow Ho, Sheng-Hsiang Lin

Open Access Research article

Developing a real-time electronic symptom monitoring system for patients after discharge following cancer-related surgery

Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova, Jane M. Blazeby

Open Access Research article

Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis

Lingming Yu, Guangyu Tao, Lei Zhu, Gang Wang, Ziming Li, Jianding Ye, Qunhui Chen

Open Access Research article

Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

Xin Yang, Kuo Zhang, Caiji Zhang, Rongxue Peng, Chengming Sun

Open Access Research article

Prevalence and factors associated with major depressive disorder in children and adolescents at the Uganda Cancer Institute

Benedict Akimana, Catherine Abbo, Joyce Balagadde-Kambugu, Etheldreda Nakimuli-Mpungu

Open Access Research article

A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: results from a prospective single-institution series

Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni, Pasquale Capaccio

Open Access Research article

Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study

Olumide B. Gbolahan, Yan Tong, Amikar Sehdev, Bert O’Neil, Safi Shahda

Open Access Research article

Comparison between opportunistic and organised breast cancer mammography screening in the Swiss canton of Fribourg

Sarah Peisl, Stefan Zimmermann, Bertrand Camey, Daniel Betticher, Christine Bouchardy

Open Access Research article

The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study

Tao-xiang Huang, Nian Lu, Shan-shan Lian, Hui Li, Shao-han Yin, Zhi-jun Geng, Chuan-miao Xie

Open Access Research article

Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor

Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin, Hsia-Han Wang, Carmen Abate, Chi-Shiun Chiang

Open Access Research article

Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer

Samantha J. Van Nest, Leah M. Nicholson, Nils Pavey, Mathew N. Hindi, Alexandre G. Brolo, Andrew Jirasek, Julian J. Lum

Open Access Research article

Predictors of distant metastasis in parotid acinic cell carcinoma

Qigen Fang, Junfu Wu, Wei Du, Xu Zhang

Open Access Research article

Prognostic value of lymphovascular invasion in patients with squamous cell carcinoma of the penis following surgery

Kai Li, Jian Sun, Xuedong Wei, Guang Wu, Fei Wang, Caibin Fan, Hexing Yuan

Open Access Research article

Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma

Xi Zhou, Huaxiong Pan, Peng Yang, Pian Ye, Haiyan Cao, Hao Zhou

Open Access Research article

Postoperative radiotherapy is effective in improving survival of patients with stage pIII-N2 non-small-cell lung Cancer after pneumonectomy

Wenhui Wang, Yu Men, Jianyang Wang, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Qinfu Feng, Jima Lv, Jun Liang, Nan Bi, Shugeng Gao, Luhua Wang, Zhouguang Hui

Open Access Research article

Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro, Rosa Noguera

Open Access Research article

Genetic associations between the miRNA polymorphisms miR-130b (rs373001), miR-200b (rs7549819), and miR-495 (rs2281611) and colorectal cancer susceptibility

Eun-Gyo Kim, Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Jisu Oh, Hak Hoon Jun, Jong Woo Kim, Nam Keun Kim

Open Access Research article

Objective evaluation of clinical outcomes of laparoscopy-assisted pylorus-preserving gastrectomy for middle-third early gastric cancer

Xiang Xia, Jia Xu, Chunchao Zhu, Hui Cao, Fengrong Yu, Gang Zhao

Open Access Research article

Comparison of weekly and triweekly cisplatin regimens during concurrent chemoradiotherapy for nasopharyngeal carcinoma

Kailin Wang, Jun Dong, Shasha He, Xia Wang, Chang Jiang, Pili Hu, Jiangui Guo, Xiuyu Cai, Xicheng Wang

Open Access Research article

Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma

Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado, Hans E. Grossniklaus

Open Access Research article

Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway

Zejia Yang, Jipei Liao, Brandon A. Carter-Cooper, Rena G. Lapidus, Kevin J. Cullen, Hancai Dan

Open Access Correction

Correction to: Decitabine plus CLAG chemotherapy as a bridge to haploidentical transplantation in the setting of acute myeloid leukemia relapse after HLA-matched sibling transplantation: a case report

Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang, Guoqing Wei

Open Access Study protocol

The LACOG-0415 phase II trial: abiraterone acetate and ADT versus apalutamide versus abiraterone acetate and apalutamide in patients with advanced prostate cancer with non-castration testosterone levels

Gustavo Werutsky, Fernando Cotait Maluf, Eduardo Henrique Cronemberger, Vinicius Carrera Souza, Suelen Patricia dos Santos Martins, Fábio Peixoto, Oren Smaletz, Fábio Schutz, Daniel Herchenhorn, Telma Santos, Flavio Mavignier Carcano, David Queiroz Muniz, Paulo R. S. Nunes Filho, Facundo Zaffaroni, Carlos Barrios, André Fay

Open Access Research article

High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer

Hanna Abrahamsson, Alina C. Porojnicu, Jonas C. Lindstrøm, Svein Dueland, Kjersti Flatmark, Knut H. Hole, Therese Seierstad, Johan Moan, Kathrine Røe Redalen, Sebastian Meltzer, Anne Hansen Ree

Open Access Research article

Pazopanib has equivalent anti-tumor effectiveness and lower Total costs than Sunitinib for treating metastatic or advanced renal cell carcinoma: a meta-analysis

Huan Deng, Yu Huang, Zhengdong Hong, Xuhui Yuan, Zhi Cao, Yiping Wei, Wenxiong Zhang

Open Access Research article

Collagen organization of renal cell carcinoma differs between low and high grade tumors

Sara L. Best, Yuming Liu, Adib Keikhosravi, Cole R. Drifka, Kaitlin M. Woo, Guneet S. Mehta, Marie Altwegg, Terra N. Thimm, Matthew Houlihan, Jeremy S. Bredfeldt, E. Jason Abel, Wei Huang, Kevin W. Eliceiri

Open Access Research article

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson, Stephen P. Ethier

Open Access Correction

Correction to: A multicenter phase III study comparing Simultaneous Integrated Boost (SIB) radiotherapy concurrent and consolidated with S-1 versus SIB alone in elderly patients with esophageal and esophagogastric cancer – the 3JECROG P-01 study protocol

Chen Li, Xiaomin Wang, Xin Wang, Chun Han, Ping Wang, Qingsong Pang, Junqiang Chen, Xinchen Sun, Lan Wang, Wencheng Zhang, Yu Lin, Xiaolin Ge, Zongmei Zhou, Wenjie Ni, Xiao Chang, Jun Liang, Lei Deng, Wenqing Wang, Yidian Zhao, Zefen Xiao

Open Access Research article

Association of newly identified genetic variant rs2853677 of TERT with non-small cell lung cancer and leukemia in population of Jammu and Kashmir, India

Gh. Rasool Bhat, Amrita Bhat, Sonali Verma, Itty Sethi, Ruchi Shah, Varun Sharma, Khursheed A. Dar, Deepak Abrol, Subiya Kaneez, Sandeep Kaul, Ramesh Ganju, Rakesh Kumar

Open Access Study protocol

Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study

Julio Plaza-Díaz, Ana I. Álvarez-Mercado, Carmen M Ruiz-Marín, Iris Reina-Pérez, Alejandro J. Pérez-Alonso, María Belén Sánchez-Andujar, Pablo Torné, Tania Gallart-Aragón, María Teresa Sánchez-Barrón, Saturnino Reyes Lartategui, Federico García, Natalia Chueca, Ana Moreno-Delgado, Katia Torres-Martínez, María José Sáez-Lara, Cándido Robles-Sánchez, Mariana F. Fernández, Luis Fontana

Open Access Research article

Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong, Sung Joo Kim

Open Access Research article

The short-term efficacy of no-touch radiofrequency ablation in treating cirrhosis-based small hepatocellular carcinoma

Yuelong Chai, Kun Li, Chang Zhang, Shihan Chen, Kuansheng Ma

Open Access Research article

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu, Yi Zhang

Open Access Research article

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

Jan Lisec, Carsten Jaeger, Rida Rashid, Rimsha Munir, Nousheen Zaidi

Open Access Technical advance

An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu, Erik S. Welf

Open Access Research article

PD-1 high expression predicts lower local disease control in stage IV M0 nasopharyngeal carcinoma

Feng Jiang, Wei Yu, Fanrui Zeng, Guoping Cheng, Jing Xu, Shifeng Yang, Yongjie Shui, Dang Wu, Xiao-fang Yu, Qichun Wei

Open Access Study protocol

Rationale and design of the German-speaking myeloma multicenter group (GMMG) trial HD6: a randomized phase III trial on the effect of elotuzumab in VRD induction/consolidation and lenalidomide maintenance in patients with newly diagnosed myeloma

Hans Salwender, Uta Bertsch, Katja Weisel, Jan Duerig, Christina Kunz, Axel Benner, Igor W. Blau, Marc Steffen Raab, Jens Hillengass, Dirk Hose, Stefanie Huhn, Michael Hundemer, Mindaugas Andrulis, Anna Jauch, Andrea Seidel-Glaetzer, Hans-Walter Lindemann, Manfred Hensel, Stefan Fronhoffs, Uwe Martens, Timon Hansen, Mohammed Wattad, Ullrich Graeven, Markus Munder, Roland Fenk, Mathias Haenel, Christof Scheid, Hartmut Goldschmidt

Open Access Research article

Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

Yun Li, Xiaoli Yan, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin, Xu Lin

Open Access Study protocol

PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer

Sandra Tuyaerts, An M. T. Van Nuffel, Eline Naert, Peter A. Van Dam, Peter Vuylsteke, Alex De Caluwé, Sandrine Aspeslagh, Piet Dirix, Lien Lippens, Emiel De Jaeghere, Frédéric Amant, Katrien Vandecasteele, Hannelore Denys

Open Access Research article

CDKN2A copy number and p16 expression in malignant pleural mesothelioma in relation to asbestos exposure

Eeva Kettunen, Sauli Savukoski, Kaisa Salmenkivi, Tom Böhling, Esa Vanhala, Eeva Kuosma, Sisko Anttila, Henrik Wolff

Open Access Research article

Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemia

H. Jonathan G. Lindström, Astrid S. de Wijn, Ran Friedman

Open Access Research article

Effect of prior cancer on survival outcomes for patients with pancreatic adenocarcinoma: a propensity score analysis

Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin

Open Access Research article

ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines

Norio Takei, Akihiro Yoneda, Marina Kosaka, Kaori Sakai-Sawada, Yasuaki Tamura

Open Access Research article

The effectiveness of TDF versus ETV on incidence of HCC in CHB patients: a meta analysis

Zeyu Zhang, Yufan Zhou, Jiajin Yang, Kuan Hu, Yun Huang

Open Access Case report

Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage

Lianjun Di, Kuang-I Fu, Xinglong Wu, Xuemei Liu, Rui Xie, Rong Zhu, Biguang Tuo

Open Access Case report

Generalized crystal-storing histiocytosis with diffuse large B-cell lymphoma and monoclonal gammopathy in a Chinese elderly woman: a case report

Qing Tao, Wenyan Zhang, Zihang Chen, Limin Gao, Jiaqi Yan, Mi Wang, Chunxiang Xiang, Weiping Liu

Open Access Research article

The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution

Adrián Mosquera Orgueira, Beatriz Antelo Rodríguez, Natalia Alonso Vence, José Ángel Díaz Arias, Nicolás Díaz Varela, Manuel Mateo Pérez Encinas, Catarina Allegue Toscano, Elena María Goiricelaya Seco, Ángel Carracedo Álvarez, José Luis Bello López

Open Access Research article

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi, Makoto Yoshimitsu, Naomichi Arima, Kenji Ishitsuka, Shin-ichi Ueno, Ken-ichiro Kosai

Open Access Research article

Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer

Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre, Paul Anthony Ellis

Open Access Research article

Lineage relationship between prostate adenocarcinoma and small cell carcinoma

Adelle D. Kanan, Eva Corey, Ricardo Z. N. Vêncio, Arjun Ishwar, Alvin Y. Liu

Open Access Research article

Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis – results from a registry-based study from Germany

Bernd Holleczek, Christa Stegmaier, Julia C. Radosa, Erich-Franz Solomayer, Hermann Brenner

Open Access Research article

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Matsubara, Takuya Ayabe

Open Access Research article

Validity and reliability of the EQ-5D-5 L in family caregivers of leukemia patients

Limin Li, Chaojie Liu, Xiuzhi Cai, Hongjuan Yu, Xueyun Zeng, Mingjie Sui, Erwei Zheng, Yang Li, Jiao Xu, Jin Zhou, Weidong Huang

Open Access Research article

Adjuvant cytokine-induced killer cell immunotherapy for hepatocellular carcinoma: a propensity score-matched analysis of real-world data

Jun Sik Yoon, Byeong Geun Song, Jeong-Hoon Lee, Hyo Young Lee, Sun Woong Kim, Young Chang, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Dong Hyun Sinn, Yoon Jun Kim, Joon Hyeok Lee, Jung-Hwan Yoon

Open Access Research article

Early prostate-specific antigen response post-abiraterone as predictor of overall survival in metastatic castrate-resistant prostate cancer

Joshua P. Schiff, Patrick Cotogno, Allison Feibus, Peter Steinwald, Elisa Ledet, Brian Lewis, Oliver Sartor

Open Access Research article

Polymorphisms in the CCR5 promoter associated with cervical intraepithelial neoplasia in a Chinese Han population

Shuyuan Liu, Jun Chen, Zhiling Yan, Shuying Dai, Chuanyin Li, Yufeng Yao, Li Shi

Open Access Research article

Clinical use of tumor biomarkers in prediction for prognosis and chemotherapeutic effect in esophageal squamous cell carcinoma

Yuchong Yang, Xuanzhang Huang, Likun Zhou, Ting Deng, Tao Ning, Rui Liu, Le Zhang, Ming Bai, Haiyang Zhang, Hongli Li, Yi Ba

Open Access Research article

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed, Fatemeh Varse, Hamid Reza Baradaran, Yousef Moradi, Sorour Khateri, Emilie Friberg, Zaher Khazaei, Saeedeh Gharahjeh, Shahrzad Tehrani, Amir-Babak Sioofy-Khojine, Zahra Najmi

Open Access Study protocol

A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol

Satoru Miura, Tateaki Naito, Shuichi Mitsunaga, Katsuhiro Omae, Keita Mori, Toshimi Inano, Teiko Yamaguchi, Noriatsu Tatematsu, Taro Okayama, Ayumu Morikawa, Takako Mouri, Hisashi Tanaka, Madoka Kimura, Hisao Imai, Takuro Mizukami, Akira Imoto, Chihiro Kondoh, Shinsuke Shiotsu, Hiroyuki Okuyama, Makoto Ueno, Toshiaki Takahashi, Tetsuya Tsuji, Hideki Aragane, Akio Inui, Takashi Higashiguchi, Koichi Takayama

Open Access Case report

Multidisciplinary approach to rare primary cardiac sarcoma: a case report and review

Audrone Vaitiekiene, Domas Vaitiekus, Laura Urbonaite, Antanas Jankauskas, Justina Portacenko, Tomas Lapinskas, Rimantas Benetis, Adakrius Siudikas, Audrone Veikutiene, Lina Poskiene, Ausra Kavoliuniene, Rasa Janciauskiene, Laimonas Jarusevicius, Elona Juozaityte, Remigijus Zaliunas, Egle Ereminiene

Open Access Research article

Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma

Lars M. Schiffmann, Heike Göbel, Heike Löser, Fabian Schorn, Jan Paul Werthenbach, Hans F. Fuchs, Patrick S. Plum, Marc Bludau, Thomas Zander, Wolfgang Schröder, Christiane J. Bruns, Hamid Kashkar, Alexander Quaas, Florian Gebauer

Open Access Research article

A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth

Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan, Kensei Nishida

Open Access Research article

First-line single-agent regorafenib in frail patients with metastatic colorectal cancer: a pilot phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)

A. Carrato, M. Benavides, B. Massutí, R. Ferreiro-Monteagudo, P. García Alfonso, E. Falcó, M. Reboredo, T. Cano, J. Gallego, J. M. Viéitez, L. Layos, A. Salud, E. Polo, E. Dotor, G. Durán-Ogalla, M. Rodriguez-Garrote, A. Calvo, E. Grande, E. Aranda

Open Access Research article

Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma

Bo Fan, Wei Wang, Xianping Zhang, Min Sun, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Qun Wang, Na Yu, Xiancheng Li

Open Access Research article

Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

Georgios N. Tsaousis, Eirini Papadopoulou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Stavroula Kampouri, Nikolaos Diamantopoulos, Theofanis Floros, Rodoniki Iosifidou, Ourania Katopodi, Anna Koumarianou, Christos Markopoulos, Konstantinos Papazisis, Vasileios Venizelos, Ioannis Xanthakis, Grigorios Xepapadakis, Eugeniu Banu, Dan Tudor Eniu, Serban Negru, Dana Lucia Stanculeanu, Andrei Ungureanu, Vahit Ozmen, Sualp Tansan, Mehmet Tekinel, Suayib Yalcin, George Nasioulas

Open Access Research article

Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors

Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter, John Foley

Open Access Research article

Intracranial aneurysms formation after radiotherapy for head and neck cancer: a 10-year nationwide follow-up study

Wei-Hsun Yang, Yao-Hsu Yang, Pau-Chung Chen, Ting-Chung Wang, Ko-Jung Chen, Chun-Yu Cheng, Chia-Hsuan Lai

Open Access Research article

Clinical and prognostic implications of pretreatment albumin to C-reactive protein ratio in patients with hepatocellular carcinoma

Mian-Tao Wu, Su-Yin He, Shu-Lin Chen, Lin-Fang Li, Zheng-Qiang He, Yuan-Ying Zhu, Xia He, Hao Chen

Open Access Case report

Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report

Michael A. Cardis, Hong Jiang, Julius Strauss, James L. Gulley, Isaac Brownell

Open Access Research article

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte, Scott H. Robbins

Open Access Research article

Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer

Yaping Yang, Ying Wang, Heran Deng, Cui Tan, Qian Li, Zhanghai He, Wei Wei, Enxiang Zhou, Qiang Liu, Jieqiong Liu

Open Access Research article

Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells

Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara, Yasutoshi Tatsumi

Open Access Research article

Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis

Vicky C. Chang, Michelle Cotterchio, Edwin Khoo

Open Access Research article

Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors

Magdalena Zakrzewska, Renata Gruszka, Konrad Stawiski, Wojciech Fendler, Joanna Kordacka, Wiesława Grajkowska, Paweł Daszkiewicz, Paweł P. Liberski, Krzysztof Zakrzewski

Open Access Research article

Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central America

Ricardo L. Dominguez, Charlotte B. Cherry, Dago Estevez-Ordonez, Robertino Mera, Veronica Escamilla, Michael Pawlita, Tim Waterboer, Keith T. Wilson, Richard M. Peek, Gloria Tavera, Scott M. Williams, Margaret L. Gulley, Michael Emch, Douglas R. Morgan

Open Access Research article

A prospective observational study to assess PD-L1 expression in small biopsy samples for non-small-cell lung cancer

Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi, Masamichi Mineshita

Open Access Research article

Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study

Willem Jan van Weelden, Kristine Eldevik Fasmer, Ingvild L. Tangen, Joanna IntHout, Karin Abbink, Antionius E. van Herwaarden, Camilla Krakstad, Leon F. A. G. Massuger, Ingfrid S. Haldorsen, Johanna M. A. Pijnenborg

Open Access Research article

Real-world treatment patterns and adverse events in metastatic renal cell carcinoma from a large US claims database

Sumanta Pal, Jun Gong, Shivani K. Mhatre, Shih-Wen Lin, Andy Surinach, Sarika Ogale, Rini Vohra, Herschel Wallen, Daniel George

Open Access Research article

Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases

Mariana Bustamante Eduardo, Vlad Popovici, Sara Imboden, Stefan Aebi, Nadja Ballabio, Hans Jörg Altermatt, Andreas Günthert, Rolf Jaggi

Open Access Research article

The value of 3D visualization operative planning system in ultrasound-guided percutaneous microwave ablation for large hepatic hemangiomas: a clinical comparative study

Xin Li, Chao An, Fangyi Liu, Zhigang Cheng, Zhiyu Han, Xiaoling Yu, Linan Dong, Jie Yu, Ping Liang

Open Access Research article

Comprehensive mutation detection of BRCA1/2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese women

Wen-Ming Cao, Ya-Bing Zheng, Yun Gao, Xiao-Wen Ding, Yan Sun, Yuan Huang, Cai-Jin Lou, Zhi-Wen Pan, Guang Peng, Xiao-Jia Wang

Open Access Technical advance

Advantages of the net benefit regression framework for trial-based economic evaluations of cancer treatments: an example from the Canadian Cancer Trials Group CO.17 trial

Jeffrey S. Hoch, Annette Hay, Wanrudee Isaranuwatchai, Kednapa Thavorn, Natasha B. Leighl, Dongsheng Tu, Logan Trenaman, Carolyn S. Dewa, Chris O’Callaghan, Joseph Pater, Derek Jonker, Bingshu E. Chen, Nicole Mittmann

Open Access Research article

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma

Ting-Xun Lu, Shuang Wu, Dong-Yan Cai, Ting-Ting Hong, Ying Zhang, Hua-Qiang Gao, Hai-Ying Hua, Xiao-Hong Wu

Open Access Research article

Advantages of using reduced-volume intensity modulated radiation therapy for the treatment of nasopharyngeal carcinoma: a retrospective paired study

Fang Liu, Ting Luo, Tao Jin, Jiahui Zhang, Zhongzheng Xiang, Ruonan Yan, Li Xie, Xin Wu, Hong Zhang, Feng Wang, Ping Li, Lei Liu

Open Access Research article

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia, Jun Sun

Open Access Research article

Aberrant expression of N-glycolyl GM3 ganglioside is associated with the aggressive biological behavior of human sarcomas

Daniel Pilco-Janeta, Myriam De la Cruz Puebla, Jorge Soriano, Marta Osorio, Iraida Caballero, Adanays Calvo Pérez, Laynes Savon, Natalia Cremades, Rancés Blanco, Adriana Carr

Open Access Research article

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

Kristi Läll, Maarja Lepamets, Marili Palover, Tõnu Esko, Andres Metspalu, Neeme Tõnisson, Peeter Padrik, Reedik Mägi, Krista Fischer

Open Access Research article

Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis

Xiaoying Sun, Raheleh Roudi, Ting Dai, Shangya Chen, Bin Fan, Hongjin Li, Yaqiong Zhou, Min Zhou, Bo Zhu, Chengqian Yin, Bin Li, Xin Li

Open Access Research article

The safety and tolerability of combined immune checkpoint inhibitors (anti-PD-1/PD-L1 plus anti-CTLA-4): a systematic review and meta-analysis

Lihu Gu, Parikshit Asutosh Khadaroo, Hui Su, Liya Kong, Liangliang Chen, Xianfa Wang, Xinlong Li, Hepan Zhu, Xin Zhong, Junhai Pan, Manman Chen

Open Access Research article

Radiotherapy for inferior vena cava tumor thrombus in patients with hepatocellular carcinoma

Tzu-Hui Pao, Wei-Ting Hsueh, Wei-Lun Chang, Nai-Jung Chiang, Yih-Jyh Lin, Yi-Sheng Liu, Forn-Chia Lin

Open Access Research article

Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells

Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess, Peeyush K. Lala

Open Access Research article

Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review

Kabelo M. B. Lekoane, Desmond Kuupiel, Tivani P. Mashamba-Thompson, Themba G. Ginindza

Open Access Research article

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes

Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii, Joel A. Malek

Open Access Research article

Cancer stigma and cancer screening attendance: a population based survey in England

Charlotte Vrinten, Ailish Gallagher, Jo Waller, Laura A. V. Marlow

Open Access Case report

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report

Eduard Callebout, Suzane Moura Ribeiro, Stephanie Laurent, Marc De Man, Liesbeth Ferdinande, Kathleen B. M. Claes, Joni Van der Meulen, Karen P. Geboes

Open Access Research article

A prospective clinical trial on sorafenib treatment of hepatocellular carcinoma before liver transplantation

Malin Sternby Eilard, Mats Andersson, Peter Naredi, Charalampos Geronymakis, Per Lindnér, Christian Cahlin, William Bennet, Magnus Rizell

Open Access Research article

Adjuvant chemoradiation in pancreatic cancer: impact of radiotherapy dose on survival

Alessio G. Morganti, Francesco Cellini, Milly Buwenge, Alessandra Arcelli, Sergio Alfieri, Felipe A. Calvo, Riccardo Casadei, Savino Cilla, Francesco Deodato, Giancarmine Di Gioia, Mariacristina Di Marco, Lorenzo Fuccio, Federica Bertini, Alessandra Guido, Joseph M. Herman, Gabriella Macchia, Bert W. Maidment III, Robert C. Miller, Francesco Minni, Paolo Passoni, Chiara Valentini, Alessia Re, William F. Regine, Michele Reni, Massimo Falconi, Vincenzo Valentini, Gian Carlo Mattiucci

Open Access Research article

Coverage of cancer services in Australia and providers’ views on service gaps: findings from a national cross-sectional survey

Jennifer Hunter, Caroline Smith, Geoff P. Delaney, Kate Templeman, Suzanne Grant, Jane M. Ussher

Open Access Research article

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Ae Kyung Park, Ji Yeoun Lee, Heesun Cheong, Vijay Ramaswamy, Sung-Hye Park, Marcel Kool, Ji Hoon Phi, Seung Ah Choi, Florence Cavalli, Michael D. Taylor, Seung-Ki Kim

Open Access Study protocol

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

Roche Kapoor, Matthew P. Deek, Riley McIntyre, Natasha Raman, Megan Kummerlowe, Iyah Chen, Matt Gaver, Hao Wang, Sam Denmeade, Tamara Lotan, Channing Paller, Mark Markowski, Michael Carducci, Mario Eisenberger, Tomasz M. Beer, Daniel Y. Song, Theodore L. DeWeese, Jason W. Hearn, Stephen Greco, Curtiland DeVille, Neil B. Desai, Elisabeth I. Heath, Stanley Liauw, Daniel E. Spratt, Arthur Y. Hung, Emmanuel S. Antonarakis, Phuoc T. Tran

Open Access Research article

Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene

Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Bent Ejlertsen, Erik Hugger Jakobsen, Dorte Lisbet Nielsen

Open Access Research article

Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations

Ji Young Park, Seung Hun Jang, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Jinwon Seo, Chang Youl Lee, Yousang Ko, Yong-Bum Park

Open Access Research article

Treatment with somatostatin analogs induces differentially expressed let-7c-5p and mir-3137 in small intestine neuroendocrine tumors

Florian Bösch, Alexandr V. Bazhin, Sabine Heublein, Katharina Brüwer, Thomas Knösel, Florian P. Reiter, Christoph J. Auernhammer, Markus O. Guba, Christine Spitzweg, Jens Werner, Martin K. Angele

Open Access Research article

CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang, Yueming Sun

Open Access Research article

MiR-890 inhibits proliferation and invasion and induces apoptosis in triple-negative breast cancer cells by targeting CD147

Cheng Wang, Cheng Xu, Ruijie Niu, Guangfu Hu, Zhangyuan Gu, Zhigang Zhuang

Open Access Research article

Health-related quality of life in patients receiving first-line eribulin mesylate with or without trastuzumab for locally recurrent or metastatic breast cancer

Lee Schwartzberg, Kristi McIntyre, Sharon Wilks, Shannon Puhalla, Joyce O’Shaughnessy, Erhan Berrak, Yaohua He, Linda Vahdat

Open Access Study protocol

Monitoring of circulating tumor DNA and its aberrant methylation in the surveillance of surgical lung Cancer patients: protocol for a prospective observational study

Guannan Kang, Kezhong Chen, Fan Yang, Shannon Chuai, Heng Zhao, Kai Zhang, Bingsi Li, Zhihong Zhang, Jun Wang

Open Access Research article

A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential

Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer, Jin-Xiong She

Open Access Study protocol

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

Sarah R. Brown, Andrew Hall, Hannah L. Buckley, Louise Flanagan, David Gonzalez de Castro, Kate Farnell, Laura Moss, Rebecca Gregory, Kate Newbold, Yong Du, Glenn Flux, Jonathan Wadsley

Open Access Research article

Choice of immobilization of stereotactic body radiotherapy in lung tumor patient by BMI

Guofu Chen, Baiqiang Dong, Guoping Shan, Xiuqin Zhang, Huarong Tang, Yuchen Li, Zhenhua Wang, Wei Xu, Gang Xu, Guiming Yan, Feiyan Zhang, Xiao Hu, Jun Yang, Yujin Xu, Ming Chen, Jin Wang

Open Access Research article

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Hanna Sallinen

Open Access Research article

Evaluating diagnostic strategies for early detection of cancer: the CanTest framework

Fiona M. Walter, Matthew J. Thompson, Ian Wellwood, Gary A. Abel, William Hamilton, Margaret Johnson, Georgios Lyratzopoulos, Michael P. Messenger, Richard D. Neal, Greg Rubin, Hardeep Singh, Anne Spencer, Stephen Sutton, Peter Vedsted, Jon D. Emery

Open Access Research article

PRAF2 overexpression predicts poor prognosis and promotes tumorigenesis in esophageal squamous cell carcinoma

Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao, Xiaofei Chen

Open Access Research article

miR-520d-5p can reduce the mutations in hepatoma cancer cells and iPSCs-derivatives

Norimasa Miura, Yoshitaka Ishihara, Yugo Miura, Mai Kimoto, Keigo Miura

Open Access Research article

Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women

Abrha G. Gebrehiwot, Daniel Seifu Melka, Yimenashu Mamo Kassaye, Tufa Gemechu, Wajana Lako, Hiroshi Hinou, Shin-Ichiro Nishimura

Open Access Research article

Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis

Jianhao Xu, Yuming Long, Liwei Ni, Xuya Yuan, Na Yu, Runhong Wu, Jialong Tao, Yusong Zhang

Open Access Case report

Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report

Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao, Jun Chen

Open Access Research article

Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma

Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine T. Huang, Susan Airhart, Carol J. Bult, Regina Gandour-Edwards, Robert G. Maki, Robin L. Jones, Joel E. Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles Keller

Open Access Case report

Multiple secondary cauda equina non-Hodgkin’s lymphoma: a case report and literature review

Yunchao Ban, Zhitao Jing, Jingyu Zou

Open Access Research article

EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer

Wenfeng Fang, Yihua Huang, Shaodong Hong, Zhonghan Zhang, Minghui Wang, Jiadi Gan, Wenjing Wang, Honglin Guo, Kai Wang, Li Zhang

Open Access Research article

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke, Ivar P. Gladhaug

Open Access Research article

The expression of S100A8/S100A9 is inducible and regulated by the Hippo/YAP pathway in squamous cell carcinomas

Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He, Xueyuan Xiao

Open Access Research article

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx, Frans van Roy

Open Access Research article

Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma

Mengqiao Xu, Xia Wang, Yanfang Pan, Xingpeng Zhao, Bin Yan, Changgeng Ruan, Lijun Xia, Yiming Zhao

Open Access Research article

Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures

Jian Li, Kathrin Halfter, Mengying Zhang, Christian Saad, Kai Xu, Bernhard Bauer, Yijiang Huang, Lei Shi, Ulrich R. Mansmann

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Prognostic assessment of breast carcinoma submitted to neoadjuvant chemotherapy with pathological non-complete response

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Mark Laible, Kerstin Hartmann, Claudia Gürtler, Tobias Anzeneder, Ralph Wirtz, Stephan Weber, Thomas Keller, Ugur Sahin, Martin Rees, Annette Ramaswamy

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Sabine Danzinger, Yen Yen Tan, Margaretha Rudas, Marie-Theres Kastner, Sigrid Weingartshofer, Daniela Muhr, Christian F. Singer

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Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer

Weiwei Gong, Yueyang Liu, Christof Seidl, Eleftherios P. Diamandis, Marion Kiechle, Enken Drecoll, Matthias Kotzsch, Viktor Magdolen, Julia Dorn

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Cyclin-dependent kinase 5 acts as a promising biomarker in clear cell Renal Cell Carcinoma

Liangsong Zhu, Rong Ding, Jianping Zhang, Jin Zhang, Zongming Lin

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J. Chantharasamee, N. Poungvarin, P. Danchaivijitr, S. Techawatanawanna

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Sirtuin1 activator SRT2183 suppresses glioma cell growth involving activation of endoplasmic reticulum stress pathway

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Ze Zhang, John K. Wiencke, Devin C. Koestler, Lucas A. Salas, Brock C. Christensen, Karl T. Kelsey

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Shaoyan Xi, Ke Sai, Wanming Hu, Fang Wang, Yinsheng Chen, Jing Wang, Jing Zeng, Zhongping Chen

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Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways

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Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo, Pirkko-Liisa Kellokumpu-Lehtinen

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Impact of age on the use of adjuvant treatments in patients undergoing surgery for colorectal cancer: patients with stage III colon or stage II/III rectal cancer

C. Sarasqueta, A. Perales, A. Escobar, M. Baré, M. Redondo, N. Fernández de Larrea, E. Briones, J. M. Piera, M. V. Zunzunegui, J. M. Quintana, Jose María Quintana, Marisa Baré, Maximino Redondo, Eduardo Briones Pérez de la Briones, Nerea Fernández de Larrea, Cristina Sarasqueta, Antonio Escobar , Francisco Rivas, Maria Morales-Suárez, Juan Antonio Blasco, Isabel del Cura , Inmaculada Arostegui, Amaia Bilbao, Nerea González , Susana García-Gutiérrez, Iratxe Lafuente, Urko Aguirre, Miren Orive, Josune Martin, Ane Antón-Ladislao, Núria Torà, Marina Pont, María Purificación Martínez del, Alberto Loizate, Ignacio Zabalza, José Errasti, Antonio Gimeno, Santiago Lázaro, Mercè Comas, Jose María Enríquez-Navascues, Carlos Placer, Amaia Perales, Iñaki Urkidi, Jose María Erro, Enrique Cormenzana, Adelaida Lacasta, Pep Piera, Elena Campano, Ana Isabel Sotelo, Segundo Gómez-Abril, F. Medina-Cano, Julia Alcaide, Arturo Del Rey-Moreno, Manuel Jesús Alcántara, Rafael Campo, Alex Casalots, Carles Pericay, Maria José Gil, Miquel Pera, Pablo Collera, Josep Alfons Espinàs, Mercedes Martínez, Mireia Espallargues, Caridad Almazán, Paula Dujovne, José María Fernández-Cebrián, Rocío Anula, Julio Mayol, Ramón Cantero, Héctor Guadalajara, María Alexandra Heras, Damián García, Mariel Morey, Alberto Colina

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SET domain containing protein 5 (SETD5) enhances tumor cell invasion and is associated with a poor prognosis in non-small cell lung cancer patients

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Short- and long-term impact of adapted physical activity and diet counseling during adjuvant breast cancer therapy: the “APAD1” randomized controlled trial

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microRNA-21 promotes breast cancer proliferation and metastasis by targeting LZTFL1

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Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells

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Selective TACE with irinotecan-loaded 40 μm microspheres and FOLFIRI for colorectal liver metastases: phase I dose escalation pharmacokinetic study

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Substantial batch effects in TCGA exome sequences undermine pan-cancer analysis of germline variants

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Open Access Case report

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Open Access Case report

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Open Access Case report

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Open Access Study protocol

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Open Access Research article

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Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König, Marian Grade

Open Access Research article

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Open Access Technical advance

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Glutamate metabotropic receptor 4 (GRM4) inhibits cell proliferation, migration and invasion in breast cancer and is regulated by miR-328-3p and miR-370-3p

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LETM1 is a potential biomarker of prognosis in lung non-small cell carcinoma

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Open Access Study protocol

Cetuximab, irinotecan and fluorouracile in fiRst-line treatment of immunologically-selected advanced colorectal cancer patients: the CIFRA study protocol

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Open Access Study protocol

Study protocols of three parallel phase 1 trials combining radical radiotherapy with the PARP inhibitor olaparib

R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen, G. S. Sonke, P. Elkhuizen, M. W. M. van den Brekel, M. E. T. Tesselaar, C. Vens, J. H. M. Schellens, B. van Triest, M. Verheij

Open Access Research article

Long-term responders to trastuzumab monotherapy in first-line HER-2+ advanced breast cancer: characteristics and survival data

Sabine Schmid, Dirk Klingbiel, Stefan Aebi, Aron Goldhirsch, Christoph Mamot, Elisabetta Munzone, Franco Nolè, Christian Oehlschlegel, Olivia Pagani, Bernhard Pestalozzi, Christoph Rochlitz, Beat Thürlimann, Roger von Moos, Patrik Weder, Khalil Zaman, Thomas Ruhstaller

Open Access Study protocol

Radioablation +/− hormonotherapy for prostate cancer oligorecurrences (Radiosa trial): potential of imaging and biology (AIRC IG-22159)

Giulia Marvaso, Delia Ciardo, Giulia Corrao, Sara Gandini, Cristiana Fodor, Dario Zerini, Damaris Patricia Rojas, Matteo Augugliaro, Giuseppina Bonizzi, Salvatore Pece, Federica Cattani, Ketti Mazzocco, Francesco Alessandro Mistretta, Gennaro Musi, Sarah Alessi, Giuseppe Petralia, Gabriella Pravettoni, Ottavio De Cobelli, Pier Paolo Di Fiore, Giuseppe Viale, Roberto Orecchia, Barbara Alicja Jereczek-Fossa

Open Access Review

A multi-disciplinary model of survivorship care following definitive chemoradiation for anal cancer

Marissa B. Savoie, Angela Laffan, Cristina Brickman, Bevin Daniels, Anna Levin, Tami Rowen, James Smith, Erin L. Van Blarigan, Thomas A. Hope, J. Michael Berry-Lawhorn, Mekhail Anwar, Katherine Van Loon

Open Access Research article

Outcomes of immediate oncoplastic surgery and adjuvant radiotherapy in breast cancer patients

Kai Joachim Borm, Christine Schönknecht, Andrea Nestler, Markus Oechsner, Birgit Waschulzik, Stephanie Elisabeth Combs, Stefan Münch, Markus Niemeyer, Marciana Nona Duma

Open Access Research article

Maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography compared with Epstein-Barr virus DNA as prognostic indicators in de novo metastatic nasopharyngeal carcinoma patients

Xue-Song Sun, Yu-Jing Liang, Sai-Lan Liu, Qiu-Yan Chen, Shan-Shan Guo, Yue-Feng Wen, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Xiao-Yun Li, Jin-Jie Yan, Lin-Quan Tang, Hai-Qiang Mai

Open Access Research article

Trastuzumab use in older patients with HER2-positive metastatic breast cancer: outcomes and treatment patterns in a whole-of-population Australian cohort (2003–2015)

Benjamin Daniels, Belinda E. Kiely, Monica Tang, Hanna Tervonen, Sallie-Anne Pearson

Open Access Research article

Differential expression of N-linked oligosaccharides in methotrexate-resistant primary central nervous system lymphoma cells

Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka, Ryuya Yamanaka

Open Access Research article

Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression

Qiong Jiang, Qing Xie, Chengliang Hu, Zhai Yang, Peizhi Huang, Huifan Shen, Melitta Schachner, Weijiang Zhao

Open Access Research article

CD73 complexes with emmprin to regulate MMP-2 production from co-cultured sarcoma cells and fibroblasts

M. Aoki, K. Koga, M. Miyazaki, M. Hamasaki, N. Koshikawa, M. Oyama, H. Kozuka-Hata, M. Seiki, B. P. Toole, K. Nabeshima

Open Access Case report

Case report of rhabdomyosarcomatous transformation of a primary gastrointestinal stromal tumor (GIST)

Li Li, Marian Khalili, Gregg Johannes, Praneeth Baratam, William F. Morano, Michael Styler, Wilbur B. Bowne, J. Steve Hou

Open Access Research article

A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice

Krishna Das, David Eisel, Mathias Vormehr, Karin Müller-Decker, Adriane Hommertgen, Dirk Jäger, Inka Zörnig, Markus Feuerer, Annette Kopp-Schneider, Wolfram Osen, Stefan B. Eichmüller

Open Access Case report

Fibrin-associated large B-cell lymphoma: first case report within a cerebral artery aneurysm and literature review

Magda Zanelli, Maurizio Zizzo, Marco Montanaro, Vito Gomes, Giovanni Martino, Loredana De Marco, Giulio Fraternali Orcioni, Maria Paola Martelli, Stefano Ascani

Open Access Research article

Preclinical efficacy of dual mTORC1/2 inhibitor AZD8055 in renal cell carcinoma harboring a TFE3 gene fusion

Eric C. Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N. Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier, Ramaprasad Srinivasan

Open Access Research article

Characterization and risk association of polymorphisms in Aurora kinases A, B and C with genetic susceptibility to gastric cancer development

Aner Mesic, Marija Rogar, Petra Hudler, Nurija Bilalovic, Izet Eminovic, Radovan Komel

Open Access Research article

Tumor-infiltrating CD8+ T cells combined with tumor-associated CD68+ macrophages predict postoperative prognosis and adjuvant chemotherapy benefit in resected gastric cancer

Jun Lu, Yu Xu, Yuan Wu, Xiao-yan Huang, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Ping Li, Chao-hui Zheng, Ai-min Huang, Chang-ming Huang

Open Access Research article

Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer

Jianhua Zhang, Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Shanshan Li, Bingjian Xue, Li Yan

Open Access Study protocol

Preoperative chemotherapy and carbon ions therapy for treatment of resectable and borderline resectable pancreatic adenocarcinoma: a prospective, phase II, multicentre, single-arm study

Viviana Vitolo, Lorenzo Cobianchi, Silvia Brugnatelli, Amelia Barcellini, Andrea Peloso, Angelica Facoetti, Alessandro Vanoli, Sara Delfanti, Lorenzo Preda, Silvia Molinelli, Catherine Klersy, Piero Fossati, Roberto Orecchia, Francesca Valvo

Open Access Research article

A way to understand idiopathic senescence and apoptosis in primary glioblastoma cells – possible approaches to circumvent these phenomena

Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske, Ewelina Stoczynska-Fidelus

Open Access Research article

Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice

Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott, Christine J. Hawkins

Open Access Case report

Gingival metastasis from primary hepatocellular carcinoma: a case report and literature review of 30 cases

Yating Hou, Weiping Deng, Gang Deng, Linhui Hu, Chao Liu, Lishu Xu

Open Access Research article

Reproductive characteristics are associated with gene-specific promoter methylation status in breast cancer

Lauren E. McCullough, Lindsay J. Collin, Kathleen Conway, Alexandra J. White, Yoon Hee Cho, Sumitra Shantakumar, Mary Beth Terry, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Jia Chen, Marilie D. Gammon

Open Access Research article

Immunohistochemical validation of COL3A1, GPR158 and PITHD1 as prognostic biomarkers in early-stage ovarian carcinomas

Hanna Engqvist, Toshima Z. Parris, Anikó Kovács, Szilárd Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson, Khalil Helou

Open Access Research article

Postoperative XELOX therapy for patients with curatively resected high-risk stage II and stage III rectal cancer without preoperative chemoradiation: a prospective, multicenter, open-label, single-arm phase II study

Tsunekazu Mizushima, Masataka Ikeda, Takeshi Kato, Atsuyo Ikeda, Junichi Nishimura, Taishi Hata, Chu Matsuda, Taroh Satoh, Masaki Mori, Yuichiro Doki

Open Access Research article

Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients

Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian, Zhao-Qun Deng

Open Access Research article

The effects of photodynamic therapy on leukemia cells mediated by KillerRed, a genetically encoded fluorescent protein photosensitizer

Meng Yuan, Chengcheng Liu, Jiao Li, Wenpeng Ma, Xiaozhuo Yu, Ping Zhang, Yanhong Ji

Open Access Research article

Interleukin-6 mediates resistance to PI3K-pathway–targeted therapy in lymphoma

Joo Hyun Kim, Won Seog Kim, Chaehwa Park

Open Access Research article

Circ-SMARCA5 suppresses progression of multiple myeloma by targeting miR-767-5p

Haiyan Liu, Yan Wu, Shunye Wang, Jie Jiang, Chenlu Zhang, Yijing Jiang, Xingfeng Wang, Lewen Hong, Hongming Huang

Open Access Research article

Intra-arterial EmboCept S® and DC Bead® effectively inhibit tumor growth of colorectal rat liver metastases

Christian Ziemann, Jonas Roller, Markus M. Malter, Kira Keller, Otto Kollmar, Matthias Glanemann, Michael D. Menger, Jens Sperling

Open Access Research article

Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer

Yidong Zhou, Yan Li, Feng Mao, Jing Zhang, Qingli Zhu, Songjie Shen, Yan Lin, Xiaohui Zhang, He Liu, Mengsu Xiao, Yuxin Jiang, Qiang Sun

Open Access Research article

Describing mortality trends for major cancer sites in 133 intermediate regions of Brazil and an ecological study of its causes

Alessandro Bigoni, José Leopoldo Ferreira Antunes, Elisabete Weiderpass, Kristina Kjærheim

Open Access Study protocol

The relationship between peripheral neuropathy and efficacy in second-line chemotherapy for unresectable advanced gastric cancer: a prospective observational multicenter study protocol (IVY)

Hiroaki Tanioka, Takeshi Nagasaka, Futoshi Uno, Masafumi Inoue, Hiroyuki Okita, Yosuke Katata, Hiromitsu Kanzaki, Hidekazu Kuramochi, Hironaga Satake, Yoshiaki Shindo, Akira Doi, Jyunichiro Nasu, Haruhiro Yamashita, Yoshiyuki Yamaguchi

Open Access Research article

Tubal ligation and endometrial Cancer risk: a global systematic review and meta-analysis

Laleh Loghmani, Nafise Saedi, Reza Omani-Samani, Saeid Safiri, Mahdi Sepidarkish, Saman Maroufizadeh, Arezoo Esmailzadeh, Maryam Shokrpour, Esmaeil Khedmati Morasae, Amir Almasi-Hashiani

Open Access Debate

Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority

Claire L. Niedzwiedz, Lee Knifton, Kathryn A. Robb, Srinivasa Vittal Katikireddi, Daniel J. Smith

Open Access Research article

High-level expression of protein tyrosine phosphatase non-receptor 12 is a strong and independent predictor of poor prognosis in prostate cancer

Sören A. Weidemann, Charlotte Sauer, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Guido Sauter, Cosima Göbel, Patrick Lebok, David Dum, Christoph Fraune, Simon Kind, Sarah Minner, Jakob Izbicki, Thorsten Schlomm, Hartwig Huland, Hans Heinzer, Eike Burandt, Alexander Haese, Markus Graefen, Asmus Heumann

Open Access Research article

Treatment and outcome of the patients with rhabdomyosarcoma of the biliary tree: Experience of the Cooperative Weichteilsarkom Studiengruppe (CWS)

Cristian Urla, Steven W. Warmann, Monika Sparber-Sauer, Andreas Schuck, Ivo Leuschner, Thomas Klingebiel, Gunnar Blumenstock, Guido Seitz, Ewa Koscielniak, Jörg Fuchs

Open Access Research article

Controlling nutritional status (CONUT) score as a preoperative risk assessment index for older patients with colorectal cancer

Yuka Ahiko, Dai Shida, Tomoko Horie, Taro Tanabe, Yasuyuki Takamizawa, Ryohei Sakamoto, Konosuke Moritani, Shunsuke Tsukamoto, Yukihide Kanemitsu

Open Access Research article

Quality of life among symptomatic compared to PSA-detected prostate cancer survivors - results from a UK wide patient-reported outcomes study

David W. Donnelly, Linda C. Vis, Therese Kearney, Linda Sharp, Damien Bennett, Sarah Wilding, Amy Downing, Penny Wright, Eila Watson, Richard Wagland, William R. Cross, Malcolm D. Mason, Sabine Siesling, Jeannette G. van Manen, Adam W. Glaser, Anna Gavin

Open Access Research article

CSB affected on the sensitivity of lung cancer cells to platinum-based drugs through the global decrease of let-7 and miR-29

Zhenbang Yang, Chunling Liu, Hongjiao Wu, Yuning Xie, Hui Gao, Xuemei Zhang

Open Access Research article

Geographic distribution and risk of upper urothelial carcinomas in Croatia, 2001–2011

Danira Medunjanin, Zdenko Sonicki, John E. Vena, Ante Cvitkovic, Sara Wagner Robb

Open Access Research article

Distinct molecular etiologies of male and female hepatocellular carcinoma

Heini M. Natri, Melissa A. Wilson, Kenneth H. Buetow

Open Access Research article

Lymph node ratio as valuable predictor in pancreatic cancer treated with R0 resection and adjuvant treatment

Min Su You, Sang Hyub Lee, Young Hoon Choi, Bang-sup Shin, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Dong Kee Jang, Jun Kyu Lee, Wooil Kwon, Jin-Young Jang, Sun-Whe Kim

Open Access Research article

Overexpression of iASPP is required for autophagy in response to oxidative stress in choriocarcinoma

Ka-Kui Chan, Esther Shuk-Ying Wong, Ivy Tsz-Lo Wong, Claire Ling-Yang Cheung, Oscar Gee-Wan Wong, Hextan Yuen-Sheung Ngan, Annie Nga-Yin Cheung

Open Access Research article

Randomized, phase II trial of sequential hepatic arterial infusion chemotherapy and sorafenib versus sorafenib alone as initial therapy for advanced hepatocellular carcinoma: SCOOP-2 trial

Masaaki Kondo, Manabu Morimoto, Satoshi Kobayashi, Shinichi Ohkawa, Hisashi Hidaka, Takahide Nakazawa, Hiroshi Aikata, Takeshi Hatanaka, Daichi Takizawa, Kotaro Matsunaga, Chiaki Okuse, Michihiro Suzuki, Masataka Taguri, Takako Ishibashi, Kazushi Numata, Shin Maeda, Katsuaki Tanaka

Open Access Research article

Comparative research on 99mTc-Rituximab and 99mTc-sulfur colloid in sentinel lymph node imaging of breast cancer

Jing-Jie Zhang, Wan-Chun Zhang, Cai-Xia An, Xiao-Min Li, Le Ma

Open Access Research article

A pair-wise meta-analysis highlights circular RNAs as potential biomarkers for colorectal cancer

Chen Li, Xinli He, Lele Zhang, Lanying Li, Wenzhao Zhao

Open Access Research article

STAT3 induces G9a to exacerbate HER3 expression for the survival of epidermal growth factor receptor-tyrosine kinase inhibitors in lung cancers

Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho, Chun-Chia Cheng

Open Access Case report

Poorly differentiated neuroendocrine rectal carcinoma with uncommon immune-histochemical features and clinical presentation with a subcutaneous metastasis, treated with first line intensive triplet chemotherapy plus bevacizumab FIr-B/FOx regimen: an experience of multidisciplinary management in clinical practice

Gemma Bruera, Antonio Giuliani, Lucia Romano, Alessandro Chiominto, Alessandra Di Sibio, Stefania Mastropietro, Pierluigi Cosenza, Enrico Ricevuto, Mario Schietroma, Francesco Carlei

Open Access Research article

Clinical outcomes and prognostic factors to predict treatment response in high risk neuroblastoma patients receiving topotecan and cyclophosphamide containing induction regimen: a prospective multicenter study

Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-on Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn, Suradej Hongeng

Open Access Research article

Multicentre, phase II study of eribulin in combination with S-1 in patients with advanced breast cancer

Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike, Kazuhiko Nakagawa

Open Access Research article

Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer

Shailesh Mahesh Advani, Pragati Shailesh Advani, Derek W. Brown, Stacia M. DeSantis, Krittiya Korphaisarn, Helena M. VonVille, Jan Bressler, David S. Lopez, Jennifer S. Davis, Carrie R. Daniel, Amir Mehrvarz Sarshekeh, Dejana Braithwaite, Michael D. Swartz, Scott Kopetz

Open Access Research article

Sarcomatoid carcinoma presenting as cancers of unknown primary: a clinicopathological portrait

Ryan W. Huey, Shalini Makawita, Lianchun Xiao, Aurelio Matamoros, Jeannelyn S. Estrella, Michael J. Overman, Gauri R. Varadhachary, Kanwal Raghav

Open Access Case report

Synchronous colonic adenoma and intestinal marginal zone B-cell lymphoma associated with Crohn’s disease: a case report and literature review

Amal Bennani, Ghizlane Kharrasse, Miry Achraf, Khanoussi Wafa, Ismaili Zahi, Kamaoui Imane, Bouziane Mohamed

Open Access Case report

Case report of oxalate nephropathy in a patient with pancreatic metastases from renal carcinoma

Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe, David R. Mole

Open Access Research article

Clinical insights gained by refining the 2016 WHO classification of diffuse gliomas with: EGFR amplification, TERT mutations, PTEN deletion and MGMT methylation

Cheila Brito, Ana Azevedo, Susana Esteves, Ana Rita Marques, Carmo Martins, Ilda Costa, Manuela Mafra, José M. Bravo Marques, Lúcia Roque, Marta Pojo

Open Access Research article

Patient-derived organoids (PDOs) as a novel in vitro model for neuroblastoma tumours

P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito, G. P. Tonini

Open Access Research article

Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, Michael Knudsen, Maria Bach Laursen, Anders Husted Madsen, Lene Hjerrild Iversen, Kåre Gotschalck Sunesen, Mads Heilskov Rasmussen, Claus Lindbjerg Andersen

Open Access Research article

TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model

Louie Semaan, Navneet Mander, Michael L. Cher, Sreenivasa R. Chinni

Open Access Research article

Correlation between immune-related adverse events and prognosis in patients with gastric cancer treated with nivolumab

Ken Masuda, Hirokazu Shoji, Kengo Nagashima, Shun Yamamoto, Masashi Ishikawa, Hiroshi Imazeki, Masahiko Aoki, Takahiro Miyamoto, Hidekazu Hirano, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Atsuo Takashima, Ken Kato, Narikazu Boku

Open Access Research article

Ectopic expression of BIRC5-targeting miR-101-3p overcomes bone marrow stroma-mediated drug resistance in multiple myeloma cells

Jahangir Abdi, Nasrin Rastgoo, Yan Chen, Guo An Chen, Hong Chang

Open Access Research article

Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating α7-nicotinic acetylcholine receptors/ERK- EMT

Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang, Yulan Yan

Open Access Technical advance

External quality assessment (EQA) program for the immunohistochemical detection of ER, PR and Ki-67 in breast cancer: results of an interlaboratory reproducibility ring study in China

Tianjie Pu, Ruohong Shui, Jie Shi, Zhiyong Liang, Wentao Yang, Hong Bu, Qin Li, Zhang Zhang, Deyu Guo, Bo Huang, Fangping Xu, Yun Ma, Jiping Qi, Qiurong Ruan, Yang Weng, Danhua Shen, Xiaomei Li, Yunte Deng, Julun Yang, Lixia Wang, Xianghong Yang, Rong Yang, Yueping Liu, Lingfei Kong, Peng Gao, Fang Mei, Xiu Nie, Min Yao, Wei Qu, Chuansheng Huang, Mei Liu, Mumin Shao, Zhihong Zhang, Jiehua He, Huaisheng Lv, Huixiang Li, Xianglei He, Shuangping Guo, Weicheng Xue, Linying Chen, Jingping Yuan, Yonghong Shi, Qing Sun, Weiqiang Zheng, Wenyong Sun, Fan Zhang, Yunjie Zeng, Wei Zhang, Chenggang Yang

Open Access Research article

Consensus in determining the resectability of locally progressed pancreatic ductal adenocarcinoma – results of the Conko-007 multicenter trial

U. A. Wittel, D. Lubgan, M. Ghadimi, O. Belyaev, W. Uhl, W. O. Bechstein, R. Grützmann, W. M. Hohenberger, A. Schmid, L. Jacobasch, R. S. Croner, A. Reinacher-Schick, U. T. Hopt, A. Pirkl, H. Oettle, R. Fietkau, H. Golcher

Open Access Research article

Atypical femoral fracture in patients with bone metastasis receiving denosumab therapy: a retrospective study and systematic review

Momoko Takahashi, Yukinori Ozaki, Rika Kizawa, Jun Masuda, Kentaro Sakamaki, Keiichi Kinowaki, Taro Umezu, Chihiro Kondoh, Yuko Tanabe, Nobuko Tamura, Yuji Miura, Takashi Shigekawa, Hidetaka Kawabata, Noriyuki Baba, Haruo Iguchi, Toshimi Takano

Open Access Research article

The diversity between curatively resected pancreatic head and body-tail cancers based on the 8th edition of AJCC staging system: a multicenter cohort study

Weiwei Sheng, Ming Dong, Guosen Wang, Xiaoyang Shi, Wei Gao, Kewei Wang, He Song, Gang Shi, Xiaodong Tan

Open Access Correction

Correction to: Advancing interdisciplinary research in head and neck cancer through a multicenter longitudinal prospective cohort study: the NETherlands QUality of life and BIomedical Cohort (NET-QUBIC) data warehouse and biobank

I. M. Verdonck-de Leeuw, F. Jansen, R. H. Brakenhoff, J. A. Langendijk, R. Takes, C. H. J. Terhaard, R. J. Baatenburg de Jong, J. H. Smit, C. R. Leemans

Open Access Research article

Global patterns and trends in ovarian cancer incidence: age, period and birth cohort analysis

Yanting Zhang, Ganfeng Luo, Mengjie Li, Pi Guo, Yuejiao Xiao, Huanlin Ji, Yuantao Hao

Open Access Technical advance

A new indocyanine green fluorescence lymphography protocol for identification of the lymphatic drainage pathway for patients with breast cancer-related lymphoedema

Hiroo Suami, Asha Heydon-White, Helen Mackie, Sharon Czerniec, Louise Koelmeyer, John Boyages

Open Access Research article

Cancer care in Brazil: structure and geographical distribution

Mario Jorge Sobreira da Silva, Gisele O’Dwyer, Claudia Garcia Serpa Osorio-de-Castro

Open Access Research article

Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study

Jun Li, Xiang-Xing Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang, Gen-Hai Li, Xiao-Jiang Ying, Xiao-Yu Dai, Min Lu, Kai Jiang, Dong-Liang Fu, Xin-Lin Li, Jin-Jie He, Jian-Wei Wang, Li-Feng Sun, Dong Xu, Jing-Yan Xu, Min Chen, Yu Tian, Jing-Song Li, Min Yan, Ying Yuan, Ke-Feng Ding

Open Access Study protocol

Nal-IRI with 5-fluorouracil (5-FU) and leucovorin or gemcitabine plus cisplatin in advanced biliary tract cancer - the NIFE trial (AIO-YMO HEP-0315) an open label, non-comparative, randomized, multicenter phase II study

L. Perkhofer, A. W. Berger, A. K. Beutel, E. Gallmeier, S. Angermeier, L. Fischer von Weikersthal, T. O. Goetze, R. Muche, T. Seufferlein, T. J. Ettrich

Open Access Research article

The prognostic impact of GSTM1/GSTP1 genetic variants in bladder Cancer

Nada Albarakati, Dareen Khayyat, Asharf Dallol, Jaudah Al-Maghrabi, Taoufik Nedjadi

Open Access Case report

Local dissemination of osteosarcoma observed after massage therapy: a case report

Shinji Miwa, Michi Kamei, Satoru Yoshida, Satoshi Yamada, Hisaki Aiba, Hiroyuki Tsuchiya, Takanobu Otsuka

Open Access Research article

BC200 overexpression contributes to luminal and triple negative breast cancer pathogenesis

Maria Barton, Julia Santucci-Pereira, Olivia G. Vaccaro, Theresa Nguyen, Yanrong Su, Jose Russo

Open Access Case report

Simultaneous primary cancer occurrence of melanoma and pulmonary adenocarcinoma in leptomeningeal metastases: a case report

Ann-Kathrin Stoppek, Sied Kebir, Andreas Junker, Kathy Keyvani, Stefan Zülow, Lazaros Lazaridis, Teresa Schmidt, Daniela Pierscianek, Martin Stuschke, Ulrich Sure, Christoph Kleinschnitz, Björn Scheffler, Lisa Zimmer, Martin Glas

Open Access Research article

Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling

Manjari Singh, Sweta Kasna, Subhadeep Roy, Sara Aldosary, Abdulaziz S. Saeedan, Mohd. Nazam Ansari, Gaurav Kaithwas

Open Access Research article

Prognostic significance of 8-hydroxy-2′-deoxyguanosine in solid tumors: a meta-analysis

Xiangcheng Qing, Deyao Shi, Xiao Lv, Baichuan Wang, Songfeng Chen, Zengwu Shao

Open Access Research article

Publication statuses of clinical trials supporting FDA-approved immune checkpoint inhibitors: a meta-epidemiological investigation

Kenji Omae, Yuki Kataoka, Yasushi Tsujimoto, Yusuke Tsutsumi, Yosuke Yamamoto, Shunichi Fukuhara, Toshi A. Furukawa

Open Access Research article

The value of GRASP on DCE-MRI for assessing response to neoadjuvant chemotherapy in patients with esophageal cancer

Yanan Lu, Ling Ma, Jianjun Qin, Zhaoqi Wang, Jia Guo, Yan Zhao, Hongkai Zhang, Xu Yan, Hui Liu, Hailiang Li, Ihab R. Kamel, Jinrong Qu

Open Access Research article

Immuno-PET imaging for non-invasive assessment of cetuximab accumulation in non-small cell lung cancer

Aiko Yamaguchi, Arifudin Achmad, Hirofumi Hanaoka, Yusri Dwi Heryanto, Anu Bhattarai, Ratianto, Erdene Khongorzul, Rini Shintawati, A. Adhipatria P. Kartamihardja, Ayaka Kanai, Yumi Sugo, Noriko S. Ishioka, Tetsuya Higuchi, Yoshito Tsushima

Open Access Research article

Female sex is associated with a lower risk of bone metastases and favourable prognosis in non-sex-specific cancers

Wenjuan Ma, Karl Peltzer, Lisha Qi, Guijun Xu, Zheng Liu, Jingyi Wang, Min Mao, Vladimir P. Chekhonin, Xin Wang, Chao Zhang

Open Access Study protocol

Confirmatory trial of non-amputative digit preservation surgery for subungual melanoma: Japan Clinical Oncology Group study (JCOG1602, J-NAIL study protocol)

Kiyo Tanaka, Yasuhiro Nakamura, Tomonori Mizutani, Taro Shibata, Arata Tsutsumida, Haruhiko Fukuda, Shigeto Matsushita, Megumi Aoki, Kenjiro Namikawa, Shuichi Ohe, Satoshi Fukushima, Naoya Yamazaki

Open Access Software

lionessR: single sample network inference in R

Marieke L Kuijjer, Ping-Han Hsieh, John Quackenbush, Kimberly Glass

Open Access Research article

The use of PanDrugs to prioritize anticancer drug treatments in a case of T-ALL based on individual genomic data

Pablo Fernández-Navarro, Pilar López-Nieva, Elena Piñeiro-Yañez, Gonzalo Carreño-Tarragona, Joaquín Martinez-López, Raúl Sánchez Pérez, Ángel Aroca, Fátima Al-Shahrour, María Ángeles Cobos-Fernández, José Fernández-Piqueras

Open Access Research article

Comprehensive transcriptomic analyses of tissue, serum, and serum exosomes from hepatocellular carcinoma patients

Robin Mjelle, Simona O. Dima, Nicolae Bacalbasa, Konika Chawla, Andrei Sorop, Dana Cucu, Vlad Herlea, Pål Sætrom, Irinel Popescu

Open Access Research article

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Screening antiproliferative drug for breast cancer from bisbenzylisoquinoline alkaloid tetrandrine and fangchinoline derivatives by targeting BLM helicase

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Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears

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Open Access Study protocol

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Flemish breast cancer screening programme: 15 years of key performance indicators (2002–2016)

M. Goossens, I. De Brabander, J. De Grève, C. Van Ongeval, P. Martens, E. Van Limbergen, E. Kellen

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Exploring new potential role of DDB2 by host cell reactivation assay in human tumorigenic cells

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Open Access Case report

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Open Access Research article

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Peipei Liu, Úna C. McMenamin, Andrew D. Spence, Brian T. Johnston, Helen G. Coleman, Chris R. Cardwell

Open Access Research article

GX15–070 (Obatoclax), a Bcl-2 family proteins inhibitor engenders apoptosis and pro-survival autophagy and increases Chemosensitivity in neuroblastoma

Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal, Hervé Sartelet

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Yuanyuan Xiao, Haijun Yang, Jian Lu, Dehui Li, Chuanzhi Xu, Harvey A. Risch

Open Access Research article

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Toru Hanamura, Koichi Ohno, Shinya Hokibara, Hideki Murasawa, Toshitsugu Nakamura, Hidehiko Watanabe, Machiko Kaizuka, Shinji Sawano, Hiroshi Koyama, Ken-ichi Ito

Open Access Research article

Expression and clinical significance of PD-L1 and BRAF expression in nasopharyngeal carcinoma

Yabing Cao, Kin Iong Chan, Gungli Xiao, Yanqun Chen, Xibin Qiu, Hu Hao, Sao Chi Mak, Tongyu Lin

Open Access Research article

Postoperative chemoradiotherapy is superior to postoperative chemotherapy alone in squamous cell lung cancer patients with limited N2 lymph node metastasis

Liyu Su, Mingqiu Chen, Huiyan Su, Yaqing Dai, Shaoxing Chen, Jiancheng Li

Open Access Research article

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Marie K. Budde, Walther Kuhn, Mignon-Denise Keyver-Paik, Friedrich Bootz, Jörg C. Kalff, Stefan C. Müller, Thomas Bieber, Peter Brossart, Hartmut Vatter, Ulrich Herrlinger, Dieter C. Wirtz, Hans H. Schild, Glen Kristiansen, Thorsten Pietsch, Stefan Aretz, Franziska Geiser, Lukas Radbruch, Rudolf H. Reich, Christian P. Strassburg, Dirk Skowasch, Markus Essler, Nicole Ernstmann, Jennifer Landsberg, Benjamin Funke, Ingo G. H. Schmidt-Wolf

Open Access Research article

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Molly J. Carroll, Carl R. Parent, David Page, Pamela K. Kreeger

Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Open Access Research article

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Steve Z. Martin, Daniel C. Wagner, Nina Hörner, David Horst, Hauke Lang, Katrin E. Tagscherer, Wilfried Roth

Open Access Research article

Dietary-phytochemical mediated reversion of cancer-specific splicing inhibits Warburg effect in head and neck cancer

Sandhya Yadav, Somnath D. Bhagat, Amit Gupta, Atul Samaiya, Aasheesh Srivastava, Sanjeev Shukla

Open Access Research article

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John H. Strickler, Christel N. Rushing, Donna Niedzwiecki, Abigail McLeod, Ivy Altomare, Hope E. Uronis, S. David Hsu, S. Yousuf Zafar, Michael A. Morse, David Z. Chang, James L. Wells, Kimberly L. Blackwell, P. Kelly Marcom, Christy Arrowood, Emily Bolch, Sherri Haley, Fatima A. Rangwala, Ace J. Hatch, Andrew B. Nixon, Herbert I. Hurwitz

Open Access Research article

Tumor budding outperforms ypT and ypN classification in predicting outcome of rectal cancer after neoadjuvant chemoradiotherapy

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Open Access Research article

β-arrestin-2 up-regulates toll-like receptor 2 signaling and inhibits apoptosis in human endometrial cancer heterotransplants in nude mice

Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun, Jianliu Wang

Open Access Research article

Stromal ColXα1 expression correlates with tumor-infiltrating lymphocytes and predicts adjuvant therapy outcome in ER-positive/HER2-positive breast cancer

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Open Access Research article

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Zusen Wang, Yongxing Li, Shixiong Zhan, Lu Zhang, Shun Zhang, Qian Tang, Miaomiao Li, Zhen Tan, Shiguo Liu, Xiaoming Xing

Open Access Research article

AIB1 sequestration by androgen receptor inhibits estrogen-dependent cyclin D1 expression in breast cancer cells

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Open Access Research article

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Prescription of pain medication among older cancer patients with and without an intellectual disability: a national register study

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Tamara Codilupi, Doreen Taube, Hanspeter Naegeli

Open Access Research article

Apparent diffusion coefficient cannot predict molecular subtype and lymph node metastases in invasive breast cancer: a multicenter analysis

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Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas

Qing Zhang, Jian-He Liu, Jing-Li Liu, Chun-Ting Qi, Lei Yan, Yu Chen, Qiang Yu

Open Access Research article

Transcriptomic analysis associated with reversal of cisplatin sensitivity in drug resistant osteosarcoma cells after a drug holiday

Divya Niveditha, Harshita Sharma, Syamantak Majumder, Sudeshna Mukherjee, Rajdeep Chowdhury, Shibasish Chowdhury

Open Access Research article

The prognostic association of SPAG5 gene expression in breast cancer patients with systematic therapy

Chenjing Zhu, Otilia Menyhart, Balázs Győrffy, Xia He

Open Access Research article

Laparoscopic versus open major liver resection for hepatocellular carcinoma: systematic review and meta-analysis of comparative cohort studies

Zi-Yu Wang, Qing-Lian Chen, Ling-Ling Sun, Shu-Ping He, Xiao-Fen Luo, Li-Shuang Huang, Jun-Hai Huang, Cheng-Ming Xiong, Chong Zhong

Open Access Research article

Risk factors of lymph node metastasis or lymphovascular invasion for early gastric cancer: a practical and effective predictive model based on international multicenter data

Jian-Xian Lin, Zu-Kai Wang, Wei Wang, Jacopo Desiderio, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Amilcare Parisi, Zhi-Wei Zhou, Chang-Ming Huang

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Tumor-associated macrophages predict prognosis in diffuse large B-cell lymphoma and correlation with peripheral absolute monocyte count

Yan-Li Li, Zhi-Hu Shi, Xian Wang, Kang-Sheng Gu, Zhi-Min Zhai

Open Access Research article

Low prevalence of p16-positive HPV-related head-neck cancers in Thailand: tertiary referral center experience

Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat, Andrey Bychkov

Open Access Research article

Recursive partitioning analysis of patients with oligometastatic non-small cell lung cancer: a retrospective study

Jia-Tao Zhang, Si-Yang Liu, Hong-Hong Yan, Yi-Long Wu, Qiang Nie, Wen-Zhao Zhong

Open Access Research article

LncRNA WT1-AS up-regulates p53 to inhibit the proliferation of cervical squamous carcinoma cells

Yunxia Zhang, Renhua Na, Xinling Wang

Open Access Research article

IFN-γ down-regulates the PD-1 expression and assist nivolumab in PD-1-blockade effect on CD8+ T-lymphocytes in pancreatic cancer

Guoping Ding, Tao Shen, Yan Chen, Mingjie Zhang, Zhengrong Wu, Liping Cao

Open Access Research article

Management of non-muscle-invasive bladder cancer: quality of clinical practice guidelines and variations in recommendations

Jing Zhang, Yunyun Wang, Hong Weng, Danqi Wang, Fei Han, Qiao Huang, Tong Deng, Xinghuan Wang, Yinghui Jin

Open Access Research article

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Tara C. Horrill, Lindsey Dahl, Esther Sanderson, Garry Munro, Cindy Garson, Carole Taylor, Randy Fransoo, Genevieve Thompson, Catherine Cook, Janice Linton, Annette S. H. Schultz

Open Access Research article

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Open Access Case report

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Adam Yan, Laura Erdman, Lillian Sung, Stacey Bernstein

Open Access Research article

Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition

Alexandra Kalmár, Zsófia Brigitta Nagy, Orsolya Galamb, István Csabai, András Bodor, Barnabás Wichmann, Gábor Valcz, Barbara Kinga Barták, Zsolt Tulassay, Peter Igaz, Béla Molnár

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Primary solid lung cancerous nodules with different sizes: computed tomography features and their variations

Zhi-gang Chu, Yan Zhang, Wang-jia Li, Qi Li, Yi-neng Zheng, Fa-jin Lv

Open Access Research article

A reactive oxygen species scoring system predicts cisplatin sensitivity and prognosis in ovarian cancer patients

Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma, Gang Chen

Open Access Research article

Current state of esophageal cancer surgery in China: a national database analysis

Ming-Lian Qiu, Jian-Bo Lin, Xu Li, Rong-Gang Luo, Bo Liu, Jing-Wei Lin

Open Access Research article

Triple negative breast cancer and platinum-based systemic treatment: a meta-analysis and systematic review

Jessa Gilda P. Pandy, Joanmarie C. Balolong-Garcia, Mel Valerie B. Cruz-Ordinario, Frances Victoria F. Que

Open Access Research article

Incidence and risk factors for acute kidney injury in head and neck cancer patients treated with concurrent chemoradiation with high-dose cisplatin

Maurice J. D. L. van der Vorst, Elisabeth C. W. Neefjes, Elisa C. Toffoli, Jolanda E. W. Oosterling-Jansen, Marije R. Vergeer, C. René Leemans, Menno P. Kooistra, Jens Voortman, Henk M. W. Verheul

Open Access Research article

CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling

Fengqin Wu, Jingjing Zhou

Open Access Research article

Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review

Yue I. Cheng, Yun Cui Gan, Dan Liu, Michael P. A. Davies, Wei Min Li, John K. Field

Open Access Research article

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Jian Gao, Wenjun Ren, Chunhong Xiao, Lie Wang, Qiaojia Huang, Zaizhong Zhang, Yuan Dang, Pengcheng Weng, Hui Wang, Xuehong Fang, Minxian Zhuang, Liying Lin, Shaoquan Chen

Open Access Research article

Less micrometastatic risk related to circulating tumor cells after endoscopic breast cancer surgery compared to open surgery

Shichao Li, Wenting Yan, Xinhua Yang, Li Chen, Linjun Fan, Haoxi Liu, Kun Liu, Yi Zhang, Jun Jiang

Open Access Research article

Adenocarcinoma with mixed subtypes is a rare but aggressive histologic subtype in colorectal cancer

Hui Sheng, Xiaoli Wei, Minjie Mao, Jincan He, Tianqi Luo, Shilin Lu, Liye Zhou, Zhixin Huang, Anli Yang

Open Access Research article

Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study

Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi, Yueying Wang

Open Access Research article

A single exercise session improves side-effects of chemotherapy in women with breast cancer: an observational study

Anna Johnsson, Ingrid Demmelmaier, Katarina Sjövall, Philippe Wagner, Håkan Olsson, Åsa B. Tornberg

Open Access Study protocol

Fostering efficacy of anti-PD-1-treatment: Nivolumab plus radiotherapy in advanced non-small cell lung cancer - study protocol of the FORCE trial

Farastuk Bozorgmehr, Adriane Hommertgen, Johannes Krisam, Felix Lasitschka, Jonas Kuon, Martin Maenz, Peter E. Huber, Laila König, Meinhard Kieser, Juergen Debus, Michael Thomas, Stefan Rieken

Open Access Research article

Aurora-a confers radioresistance in human hepatocellular carcinoma by activating NF-κB signaling pathway

Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang, Long-Bang Chen

Open Access Research article

Influence of pre-operative oral carbohydrate loading vs. standard fasting on tumor proliferation and clinical outcome in breast cancer patients ─ a randomized trial

Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen, Jan P. A. Baak

Open Access Case report

BAP1 tumor predisposition syndrome case report: pathological and clinical aspects of BAP1-inactivated melanocytic tumors (BIMTs), including dermoscopy and confocal microscopy

Bianca Costa Soares de Sá, Mariana Petaccia de Macedo, Giovana Tardin Torrezan, Juliana Casagrande Tavoloni Braga, Felipe Fidalgo, Luciana Facure Moredo, Rute Lellis, João Pereira Duprat, Dirce Maria Carraro

Open Access Research article

Dual oxidase 1 and NADPH oxidase 2 exert favorable effects in cervical cancer patients by activating immune response

Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Gwanghun Kim, Parul Singh, Ha Neul Kim, Hei-Gwon Choi, Heon Jong Yoo, Young Bok Ko, Byung Seok Lee, Hyuk Soo Eun

Open Access Research article

Optimal treatment for elderly patients with resectable proximal gastric carcinoma: a real world study based on National Cancer Database

Xuefei Wang, Junjie Zhao, Mark Fairweather, Tingsong Yang, Yihong Sun, Jiping Wang

Open Access Research article

Ruxolitinib shows activity against Hodgkin lymphoma but not primary mediastinal large B-cell lymphoma

Seok Jin Kim, Dok Hyun Yoon, Hye Jin Kang, Jung Yong Hong, Ho Sup Lee, Sung Yong Oh, Ho-Jin Shin, Jee Hyun Kong, Jun Ho Yi, Kana Sakamoto, Young Hyeh Ko, Jooryung Huh, Seung-Sook Lee, Kengo Takeuchi, Dong-Yeop Shin, Cheolwon Suh, Won Seog Kim

Open Access Technical advance

Technical advance in targeted NGS analysis enables identification of lung cancer risk-associated low frequency TP53, PIK3CA, and BRAF mutations in airway epithelial cells

Daniel J. Craig, Thomas Morrison, Sadik A. Khuder, Erin L. Crawford, Leihong Wu, Joshua Xu, Thomas M. Blomquist, James C. Willey

Open Access Research article

Longitudinal associations between BMI change and the risks of colorectal cancer incidence, cancer-relate and all-cause mortality among 81,388 older adults

Ji-Bin Li, Sheng Luo, Martin C. S. Wong, Cai Li, Li-Fen Feng, Jian-Hong Peng, Jing-Hua Li, Xi Zhang

Open Access Research article

Novel HDGF/HIF-1α/VEGF axis in oral cancer impacts disease prognosis

Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee, Ming-Hong Tai

Open Access Research article

Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai, Shudao Xiong

Open Access Research article

Cytokeratin 7-negative and GATA binding protein 3-negative breast cancers: Clinicopathological features and prognostic significance

Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick, Yihong Wang

Open Access Research article

Can ELABELA be a novel target in the treatment of chronic lymphocytic leukaemia?

Didar Yanardag Acik, Mehmet Bankir, Filiz Alkan Baylan, Bilal Aygun

Open Access Research article

Glioma SOX2 expression decreased after adjuvant therapy

Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng, Qichun Wei

Open Access Research article

Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma

Takahiro Maeda, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Kengo Kanayama, Susumu Maruta, Yuko Kusakabe, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Ryo Nakagawa, Ryosuke Muroyama, Tatsuo Kanda, Hitoshi Maruyama, Naoya Kato

Open Access Research article

Breast cancer risk status influences uptake, retention and efficacy of a weight loss programme amongst breast cancer screening attendees: two randomised controlled feasibility trials

Michelle Harvie, Mary Pegington, David French, Grace Cooper, Sarah McDiarmid, Anthony Howell, Louise Donnelly, Helen Ruane, Katharine Sellers, Philip Foden, D. Gareth Evans

Open Access Research article

The Clinicopathological features and survival outcomes of patients with different metastatic sites in stage IV breast cancer

Ru Wang, Yayun Zhu, Xiaoxu Liu, Xiaoqin Liao, Jianjun He, Ligang Niu

Open Access Review

System-based approaches as prognostic tools for glioblastoma

Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy, Jochen H. M. Prehn

Open Access Research article

MiR-155 promotes anaplastic thyroid cancer progression by directly targeting SOCS1

Wei Zhang, Wenyue Ji, Xudong Zhao

Open Access Research article

EZH2 upregulation by ERα induces proliferation and migration of papillary thyroid carcinoma

Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng, Huanbai Xu

Open Access Research article

Frozen section accurately allows pathological characterization of endometrial cancer in patients with a preoperative ambiguous or inconclusive diagnoses: our experience

A. Santoro, A. Piermattei, F. Inzani, G. Angelico, M. Valente, D. Arciuolo, S. Spadola, M. Martini, F. Fanfani, A. Fagotti, V. Gallotta, G. Scambia, G. F. Zannoni

Open Access Research article

Advanced neoplasia in Veterans at screening colonoscopy using the National Cancer Institute Risk Assessment Tool

Laura W. Musselwhite, Thomas S. Redding IV, Kellie J. Sims, Meghan C. O’Leary, Elizabeth R. Hauser, Terry Hyslop, Ziad F. Gellad, Brian A. Sullivan, David Lieberman, Dawn Provenzale

Open Access Case report

Primary low grade myxofibrosarcoma of the liver with benign presentation but malignant outcome: a case report

Zigong Shao, Baoping Jiao, Juanhan Yu, Hao Liu

Open Access Research article

Factors analysis on the use of key quality indicators for narrowing the gap of quality of care of breast cancer

Chao Wang, Xi Li, Shaofei Su, Xinyu Wang, Jingkun Li, Xiaoqiang Bao, Meina Liu

Open Access Research article

The effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing immune checkpoint inhibitor treatment: a retrospective study

Hyunho Kim, Ji Eun Lee, Sook Hee Hong, Myung Ah. Lee, Jin Hyoung Kang, In-Ho Kim

Open Access Research article

Determination of the androgen receptor status of circulating tumour cells in metastatic breast cancer patients

Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni, Tanja Fehm

Open Access Study protocol

PRISM protocol: a randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic renal cell carcinoma

Hannah L. Buckley, Fiona J. Collinson, Gemma Ainsworth, Heather Poad, Louise Flanagan, Eszter Katona, Helen C. Howard, Geraldine Murden, Rosamonde E. Banks, Joanne Brown, Galina Velikova, Tom Waddell, Kate Fife, Paul D. Nathan, James Larkin, Thomas Powles, Sarah R. Brown, Naveen S. Vasudev

Open Access Research article

The value of miR-155 as a biomarker for the diagnosis and prognosis of lung cancer: a systematic review with meta-analysis

Chuchu Shao, Fengming Yang, Zhiqiang Qin, Xinming Jing, Yongqian Shu, Hua Shen

Open Access Research article

Relationship between WBRT total dose, intracranial tumor control, and overall survival in NSCLC patients with brain metastases - a single-center retrospective analysis

Zhensheng Li, Dongxing Shen, Jian Zhang, Jun Zhang, Fang Yang, Deyou Kong, Jie Kong, Andu Zhang

Open Access Research article

Incidence of atrial fibrillation in different major cancer subtypes: a Nationwide population-based 12 year follow up study

Christina Boegh Jakobsen, Morten Lamberts, Nicholas Carlson, Morten Lock-Hansen, Christian Torp-Pedersen, Gunnar H. Gislason, Morten Schou

Open Access Research article

Lapatinib sensitivity in nasopharyngeal carcinoma is modulated by SIRT2-mediated FOXO3 deacetylation

Sathid Aimjongjun, Zimam Mahmud, Yannasittha Jiramongkol, Glowi Alasiri, Shang Yao, Ernesto Yagüe, Tavan Janvilisri, Eric W.-F. Lam

Open Access Research article

Failure patterns after curative resection for intrahepatic cholangiocarcinoma: possible implications for postoperative radiotherapy

Wei Yu, Chunxiu Hu, Yongjie Shui, Kui Wu, Lili Zhang, Ying Chen, Chao Li, Jing Xu, Qichun Wei

Open Access Case report

Circulating tumour DNA (ctDNA) as a biomarker in metachronous melanoma and colorectal cancer- a case report

Leslie Calapre, Lydia Warburton, Michael Millward, Elin S. Gray

Open Access Study protocol

Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial

Pieter D. de Veij Mestdagh, Willem H. Schreuder, Wouter V. Vogel, Maarten L. Donswijk, Eric van Werkhoven, Jacqueline E. van der Wal, Richard Dirven, Baris Karakullukcu, Jan-Jakob Sonke, Michiel W. M. van den Brekel, Corrie A. M. Marijnen, Abrahim Al-Mamgani

Open Access Research article

Characterizing MRI features of rectal cancers with different KRAS status

Yanyan Xu, Qiaoyu Xu, Yanhui Ma, Jianghui Duan, Haibo Zhang, Tongxi Liu, Lu Li, Hongliang Sun, Kaining Shi, Sheng Xie, Wu Wang

Open Access Correction

Correction to: Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im

Open Access Research article

Expression of the luteinizing hormone receptor (LHR) in ovarian cancer

Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein, Jacek Pinski

Open Access Database

A gene expression-based study on immune cell subtypes and glioma prognosis

Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue, Gui-hai Zhang

Open Access Research article

Efficacy, safety and feasibility of fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting in pediatric patients receiving moderately and highly emetogenic chemotherapy – results of a non-interventional observation study

Semjon Willier, Karin Melanie Cabanillas Stanchi, Martina von Have, Vera Binder, Franziska Blaeschke, Judith Feucht, Tobias Feuchtinger, Michaela Döring

Open Access Case report

Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature

Marc Prablek, Visish M. Srinivasan, Aditya Srivatsan, Stephanie Holdener, Mazen Oneissi, Kent A. Heck, Ali Jalali, Jacob Mandel, Ashwin Viswanathan, Akash J. Patel

Open Access Research article

Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, Wan-Yun Chou, Yong-Chen Chen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You, Chien-An Sun

Open Access Research article

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

H. Sallinen, S. Janhonen, P. Pölönen, H. Niskanen, O. H. Liu, A. Kivelä, J. M. Hartikainen, M. Anttila, M. Heinäniemi, S. Ylä-Herttuala, M. U. Kaikkonen

Open Access Research article

The long-term survival of patients with III-IVb stage nasopharyngeal carcinoma treated with IMRT with or without Nimotuzumab: a propensity score-matched analysis

Wang Zhi-Qiang, Mei Qi, Li Ji-Bin, You Rui, Liu You-Ping, Sun Rui, Hu Guang-Yuan, Chen Ming-Yuan, Hua Yi-Jun

Open Access Research article

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang, Wei-Xian Chen

Open Access Research article

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells

Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen, Rod T. Mitchell

Open Access Research article

A comparison between triplet and doublet chemotherapy in improving the survival of patients with advanced gastric cancer: a systematic review and meta-analysis

Xinjian Guo, Fuxing Zhao, Xinfu Ma, Guoshuang Shen, Dengfeng Ren, Fangchao Zheng, Feng Du, Ziyi Wang, Raees Ahmad, Xinyue Yuan, Junhui Zhao, Jiuda Zhao

Open Access Research article

Synergism of wt-p53 and synthetic material in local nano-TAE gene therapy of hepatoma: comparison of four systems and the possible mechanism

Gaopeng Li, Wenqin Kang, Mingliang Jin, Lidong Zhang, Jian Zheng, Kai Jia, Jinfeng Ma, Ting Liu, Xueyi Dang, Zhifeng Yan, Zefeng Gao, Jun Xu

Open Access Research article

Exploring the value of new preoperative inflammation prognostic score: white blood cell to hemoglobin for gastric adenocarcinoma patients

Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng, Chang-Ming Huang

Open Access Research article

Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis

Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu, Hai-Bin Yu

Open Access Research article

Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

Md. Zubbair Malik, Keilash Chirom, Shahnawaz Ali, Romana Ishrat, Pallavi Somvanshi, R. K. Brojen Singh

Open Access Debate

MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators

Afra Z. Daoud, Eoghan J. Mulholland, Grace Cole, Helen O. McCarthy

Open Access Research article

Detection of disseminated tumor cells in bone marrow predict late recurrences in operable breast cancer patients

Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen, Bjørnar Gilje

Open Access Research article

Smoking related lung cancer mortality by education and sex in Norway

Merethe S. Hansen, Idlir Licaj, Tonje Braaten, Arnulf Langhammer, Loic Le Marchand, Inger Torhild Gram

Open Access Study protocol

Study protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer

Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke, Johanna W. Wilmink

Open Access Research article

The role of vascular mimicry as a biomarker in malignant melanoma: a systematic review and meta-analysis

Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan, Qinglian Wen

Open Access Case report

Application of contrast-enhanced ultrasonography in the diagnosis of post-kidney transplant lymphoproliferative disorder in native kidney- a case report

Jian-Chao Zhang, Hui-Xia Lan, Hui-Juan Zhao, Yang-Yang Lei, Li Ma, Xiao-Yan Xie, Ming-de Lu, Wei Wang

Open Access Research article

Preoperative risk stratification for early recurrence of HBV-related hepatocellular carcinoma after deceased donor liver transplantation: a five-eight model development and validation

Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Lidan Lin, Zhou Shao, Haijun Guo, Haiyang Xie, Lin Zhou, Shusen Zheng, Xiao Xu

Open Access Research article

Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer

Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki, Ken-Ichiro Yoshida

Open Access Research article

Evaluation of an online knowledge translation intervention to promote cancer risk reduction behaviours: findings from a randomized controlled trial

Sarah E. Neil-Sztramko, Emily Belita, Anthony J. Levinson, Jennifer Boyko, Maureen Dobbins

Open Access Research article

Growth rates of malignant and benign thyroid nodules in an ultrasound follow-up study: a retrospective cohort study

Michael Cordes, Theresa Ida Götz, Karen Horstrup, Torsten Kuwert, Christian Schmidkonz

Open Access Research article

CYR61, a potential biomarker of tumor inflammatory response in epithelial ovarian cancer microenvironment of tumor progress

Jun Shi, Rongfen Huo, Ningli Li, Haichuan Li, Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu, Wen Di

Open Access Research article

Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk, Katarzyna Drabko

Open Access Research article

β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu, Fan Deng

Open Access Research article

Biopsychosocial and clinical characteristics in patients with resected breast and colon cancer at the beginning and end of adjuvant treatment

Teresa García-García, Alberto Carmona-Bayonas, Paula Jimenez-Fonseca, Carlos Jara, Carmen Beato, Beatriz Castelo, Montserrat Mangas, Eva Martínez de Castro, Avinash Ramchandani, David Gomez, Caterina Calderón

Open Access Research article

Dose-volume parameters predict radiation pneumonitis after induction chemoradiotherapy followed by surgery for non-small cell lung cancer: a retrospective analysis

Kuniaki Katsui, Takeshi Ogata, Kenta Watanabe, Norihisa Katayama, Junichi Soh, Masahiro Kuroda, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka, Susumu Kanazawa

Open Access Research article

Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz, Maria A. Ramos-Arroyo

Open Access Research article

Dual time point 18F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (18F-FDG PET/CT) in primary breast cancer

Yoji YAMAGISHI, Tomomi KOIWAI, Tamio YAMASAKI, Takahiro EINAMA, Makiko FUKUMURA, Miyuki HIRATSUKA, Takako KONO, Katsumi HAYASHI, Jiro ISHIDA, Hideki UENO, Hitoshi TSUDA

Open Access Research article

Increased risk of lymphoid malignancy in patients with herpes zoster: a longitudinal follow-up study using a national cohort

Hyo Geun Choi, James L. Zehnder, Young Kyung Lee, Hyun Lim, Miyoung Kim

Open Access Case report

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

Pierre R. Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan, Carlos Torres

Open Access Research article

Clinical and imaging features of myeloid sarcoma: a German multicenter study

Hans-Jonas Meyer, Wolfram Pönisch, Stefan Andreas Schmidt, Susanne Wienbeck, Friederike Braulke, Dominik Schramm, Alexey Surov

Open Access Research article

Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time

Mian Wang, Hui Lin Cheng, Violeta Lopez, Raghav Sundar, Janelle Yorke, Alex Molassiotis

Open Access Research article

Detection of carcinogen-induced bladder cancer by fluorocoxib A

Jennifer Bourn, Kusum Rathore, Robert Donnell, Wesley White, Md. Jashim Uddin, Lawrence Marnett, Maria Cekanova

Open Access Study protocol

Low lean mass and chemotherapy toxicity risk in the elderly: the Fraction study protocol

Zara Steinmeyer, Stéphane Gérard, Thomas Filleron, Stéphanie Lozano, Delphine Brechemier, Gabor Abellan Van Kan, Loic Mourey, Laurence Cristol-Dalstein, Laure De Decker, Yves Rolland, Laurent Balardy

Open Access Research article

Molecular subtyping improves prognostication of Stage 2 colorectal cancer

Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson, Francis A. Frizelle

Open Access Research article

Prognostic factors and a new scoring system for survival of patients irradiated for bone metastases

Dirk Rades, Rapha Haus, Steven E. Schild, Stefan Janssen

Open Access Research article

LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis

Yi Hu, Yan Ma, Jie Liu, Yanlin Cai, Mengmeng Zhang, Xiaoling Fang

Open Access Research article

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study

Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen, Irina Gromova

Open Access Research article

MPPa-PDT suppresses breast tumor migration/invasion by inhibiting Akt-NF-κB-dependent MMP-9 expression via ROS

Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu, Dingqun Bai

Open Access Research article

RETRACTED ARTICLE: Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells

Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui, Yongjun Mao

Open Access Research article

Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis

Zhenhua Liu, Hongtai Shi, Longyun Chen

Open Access Study protocol

Radiotherapy for metastatic spinal cord compression with increased radiation doses (RAMSES-01): a prospective multicenter study

Dirk Rades, Olfred Hansen, Lars Henrik Jensen, Liesa Dziggel, Christian Staackmann, Claudia Doemer, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Raquel Ciervide-Jurio, Carmen Rubio-Rodriguez, Luis A. Perez-Romasanta, Ana Alvarez-Gracia, Kristopher Dennis, Carlos Ferrer-Albiach, Arturo Navarro-Martin, Fernando Lopez-Campos, Natalia Jankarashvili, Stefan Janssen, Denise Olbrich, Niels Henrik Holländer

Open Access Correction

Correction to: Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion

Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma, Shixuan Wang

Open Access Research article

Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients

Jiayu Liang, Zhihong Liu, Xin Wei, Liang Zhou, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu, Yuchun Zhu

Open Access Research article

PPARα ligand, AVE8134, and cyclooxygenase inhibitor therapy synergistically suppress lung cancer growth and metastasis

Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen, Daowen Wang

Open Access Research article

Baseline circulating stem-like cells predict survival in patients with metastatic breast Cancer

Chun-Hui Lee, Jason Chia-Hsun Hsieh, Tyler Min-Hsien Wu, Ting-Shiuan Yeh, Hung-Ming Wang, Yung-Chan Lin, Jen-Shi Chen, Chia-Lin Lee, Wen-Kuan Huang, Tsung-Min Hung, Tzu-Tsen Yen, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Ching-Chih Hu, Pei-Hung Chang

Open Access Research article

Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience

Jianjun Zhang, Yujing Huang, Yuanjue Sun, Aina He, Yan Zhou, Haiyan Hu, Yang Yao, Zan Shen

Open Access Research article

Elevated levels of serum urokinase plasminogen activator predict poor prognosis in hepatocellular carcinoma after resection

Ming-Chao Tsai, Yi-Hao Yen, Kuo-Chin Chang, Chao-Hung Hung, Chien-Hung Chen, Ming-Tsung Lin, Tsung-Hui Hu

Open Access Research article

Correlation of prechemotherapy urinary megalin ectodomain (A-megalin) levels with the development of cisplatin-induced nephrotoxicity: a prospective observational study

Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu, Akihiko Saito

Open Access Research article

Identification of differentially expressed lncRNAs and mRNAs in luminal-B breast cancer by RNA-sequencing

Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei, Ying-Ying Liu

Open Access Research article

Biological treatment of pediatric sarcomas by combined virotherapy and NK cell therapy

Chihab Klose, Susanne Berchtold, Marina Schmidt, Julia Beil, Irina Smirnow, Sascha Venturelli, Markus Burkard, Rupert Handgretinger, Ulrich M. Lauer

Open Access Research article

CAIX is a predictor of pathological complete response and is associated with higher survival in locally advanced breast cancer submitted to neoadjuvant chemotherapy

Wilson Eduardo Furlan Matos Alves, Murilo Bonatelli, Rozany Dufloth, Lígia Maria Kerr, Guilherme Freire Angotti Carrara, Ricardo Filipe Alves da Costa, Cristovam Scapulatempo-Neto, Daniel Tiezzi, René Aloísio da Costa Vieira, Céline Pinheiro

Open Access Research article

Clonal relationship of synchronous head and neck cancer and esophageal cancer assessed by single nucleotide polymorphism-based loss of heterozygosity analysis

Somkiat Sunpaweravong, Sacarin Bunbanjerdsuk, Tanjitti Pongrujikorn, Chaiwat Naktang, Patrapim Sunpaweravong, Anupong Nitiruangjaras, Tanadech Dechaphankul, Natini Jinawath

Open Access Research article

Comparison of tumour and serum specific microRNA changes dissecting their role in pancreatic ductal adenocarcinoma: a meta-analysis

Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Piyali Sarkar, Shatakshee Chatterjee, Debashis Nath, Kshaunish Das, Srikanta Goswami

Open Access Research Article

Comparing biological information contained in mRNA and non-coding RNAs for classification of lung cancer patients

Johannes Smolander, Alexey Stupnikov, Galina Glazko, Matthias Dehmer, Frank Emmert-Streib

Open Access Correction

Correction to: LC3B globular structures correlate with survival in esophageal adenocarcinoma

Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan, Sharon L. McKenna

Open Access Research article

Sustained degradation of quality of life in a subgroup of lymphoma survivors: a two-year prospective survey

Gisèle Compaci, Cécile Conte, Lucie Oberic, Loïc Ysebaert, Guy Laurent, Fabien Despas

Open Access Research article

Tumor suppressor HIC1 is synergistically compromised by cancer-associated fibroblasts and tumor cells through the IL-6/pSTAT3 axis in breast cancer

Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi, Mingang Hao

Open Access Research article

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo

Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm, Claudia R. Ball

Open Access Research article

Renal cell carcinoma lung metastases treated by radiofrequency ablation integrated with systemic treatments: over 10 years of experience

Alexis Gonnet, Laura Salabert, Guilhem Roubaud, Vittorio Catena, Véronique Brouste, Xavier Buy, Marine Gross Goupil, Alain Ravaud, Jean Palussière

Open Access Research article

Metabolic consequences of perioperative oral carbohydrates in breast cancer patients — an explorative study

Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland, Jan P. A. Baak

Open Access Study protocol

Multicenter phase III randomized trial comparing laparoscopy and laparotomy for colon cancer surgery in patients older than 75 years: the CELL study, a Fédération de Recherche en Chirurgie (FRENCH) trial

Gilles Manceau, Antoine Brouquet, Pascal Chaibi, Guillaume Passot, Olivier Bouché, Murielle Mathonnet, Jean-Marc Regimbeau, Rea Lo Dico, Jérémie H. Lefèvre, Frédérique Peschaud, Olivier Facy, Enrico Volpin, Elie Chouillard, Laura Beyert-Berjot, Marc Verny, Mehdi Karoui, Stéphane Benoist

Open Access Research article

Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer

Toshiyuki Kosuga, Tomoki Konishi, Takeshi Kubota, Katsutoshi Shoda, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Michihiro Kudou, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi, Eigo Otsuji

Open Access Research article

The impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues

Michal Marczyk, Chunxiao Fu, Rosanna Lau, Lili Du, Alexander J. Trevarton, Bruno V. Sinn, Rebekah E. Gould, Lajos Pusztai, Christos Hatzis, W. Fraser Symmans

Open Access Research article

Ages of hepatocellular carcinoma occurrence and life expectancy are associated with a UGT2B28 genomic variation

Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh, Kung-Hao Liang

Open Access Research article

HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis

Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld, Peter Schirmacher, Benjamin Goeppert

Open Access Research article

Remodeling of hepatic stellate cells orchestrated the stroma-derived oxaliplatin-resistance through CCN3 paracrine in hepatocellular carcinoma

Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning, Qingan Jia

Open Access Case report

Fatal myositis and spontaneous haematoma induced by combined immune checkpoint inhibitor treatment in a patient with pancreatic adenocarcinoma

Yuan Liu, Zhi Liu, Xuejun Zeng, Chunmei Bai, Lin Chen, Songbai Lin, Xinlun Tian

Open Access Research article

Prognostic impact of platinum sensitivity in ovarian carcinoma patients with brain metastasis

Alexandre André Balieiro Anastácio da Costa, Elizabeth Santana dos Santos, Deborah Porto Cotrim, Natasha Carvalho Pandolfi, Marcelle Goldner Cesca, Henrique Mantoan, Solange Moraes Sanches, Adriana Regina Gonçalves Ribeiro, Louise de Brot, Graziele Bonvolim, Paulo Issamu Sanematsu, Ronaldo Pereira de Souza, Joyce Maria Lisboa Maya, Fabrício de Souza Castro, João Paulo da Nogueira Silveira Lima, Michael Jenwel Chen, Andrea Paiva Gadelha Guimarães, Glauco Baiocchi

Open Access Research article

UPLC-MS based urine untargeted metabolomic analyses to differentiate bladder cancer from renal cell carcinoma

Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang, Wei Sun

Open Access Case report

Case report of ascending colon cancer and multiple jejunal GISTs in a patient with neurofibromatosis type 1 (NF1)

Liang Shang, Zhen Fang, Jin Liu, Fengying Du, Haiyan Jing, Yali Xu, Kangdi Dong, Xiaoman Zhang, Hao Wu, Changqing Jing, Leping Li

Open Access Case report

Impact of [64Cu][Cu(ATSM)] PET/CT in the evaluation of hypoxia in a patient with Glioblastoma: a case report

Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini, Umberto Sabatini

Open Access Research article

Nomograms to predict individual prognosis of patients with squamous cell carcinoma of the urinary bladder

Guanghao Zhang, Zhiwei Li, Daoqing Song, Zhiqing Fang

Open Access Research article

Predictive factors for the presence of invasive components in patients diagnosed with ductal carcinoma in situ based on preoperative biopsy

Kwan Ho Lee, Jeong Woo Han, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Chan Heun Park

Open Access Research article

Prognostic implications of forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) in epithelial ovarian cancer

Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim

Open Access Research article

miR-762 activation confers acquired resistance to gefitinib in non-small cell lung cancer

Peng Ge, Lei Cao, Xin Chen, Ruijun Jing, Wanxia Yue

Open Access Research article

Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients

Takumi Kishimoto, Nobukazu Fujimoto, Takeshi Ebara, Toyonori Omori, Tetsuya Oguri, Akio Niimi, Takako Yokoyama, Munehiro Kato, Ikuji Usami, Masayuki Nishio, Kosho Yoshikawa, Takeshi Tokuyama, Mouka Tamura, Yoshifumi Yokoyama, Ken Tsuboi, Yoichi Matsuo, Jiegou Xu, Satoru Takahashi, Mohamed Abdelgied, William T. Alexander, David B. Alexander, Hiroyuki Tsuda

Open Access Study protocol

Assessment of precision irradiation in early non-small cell lung cancer and interstitial lung disease (ASPIRE-ILD): study protocol for a phase II trial

David A. Palma, Hanbo Chen, Houda Bahig, Stewart Gaede, Stephen Harrow, Joanna M. Laba, X. Melody Qu, George B. Rodrigues, Brian P. Yaremko, Edward Yu, Alexander V. Louie, Inderdeep Dhaliwal, Christopher J. Ryerson

Open Access Research article

Radical radiotherapy in patients with cervix uteri carcinoma: experience of Ondokuz Mayis University

Alparslan Serarslan, Bilge Gursel, Deniz Meydan, Nilgun Ozbek Okumus

Open Access Research article

A systematic review of lenvatinib and sorafenib for treating progressive, locally advanced or metastatic, differentiated thyroid cancer after treatment with radioactive iodine

Nigel Fleeman, Rachel Houten, Marty Chaplin, Sophie Beale, Angela Boland, Yenal Dundar, Janette Greenhalgh, Rui Duarte, Aditya Shenoy

Open Access Research article

Dickkopf-related protein 1, a new biomarker for local immune status and poor prognosis among patients with colorectal liver Oligometastases: a retrospective study

Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang, Pei-Rong Ding

Open Access Research article

Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly

Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong, Paul K. S. Chan

Open Access Research article

TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle, Claire M. Wells

Open Access Study protocol

Standard (8 weeks) vs long (12 weeks) timing to minimally-invasive surgery after NeoAdjuvant Chemoradiotherapy for rectal cancer: a multicenter randomized controlled parallel group trial (TiMiSNAR)

Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldarti, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore, Roberto Delpini, Riccardo Rosati, Federico Perna, Andrea Coratti, Benedetta Menegatti, Sergio Gentilli, Paolo Baroffio, Piero Buccianti, Riccardo Balestri, Cristina Ceccarelli, Valter Torri, Davide Cavaliere, Leonardo Solaini, Giorgio Ercolani, Elena Traverso, Vittorio Fusco, Maura Rossi, Fabio Priora, G. Numico, Paola Franzone, Sara Orecchia

Open Access Research article

Preoperative plasma fatty acid metabolites inform risk of prostate cancer progression and may be used for personalized patient stratification

Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann, Marianna Kruithof-de Julio

Open Access Research article

Mycotoxin exposure is associated with increased risk of esophageal squamous cell carcinoma in Huaian area, China

Kathy S. Xue, Lili Tang, Guiju Sun, Shaokang Wang, Xu Hu, Jia-Sheng Wang

Open Access Research article

Vaginal dose of radical radiotherapy for cervical cancer in China: a multicenter study

Juan Wang, Kai-shuo Zhang, Tao Wang, Zi Liu, Rui-hua Wang, Fu-quan Zhang, Lang Yu, Li Ran, Jian-li He, Ya-li Wang, Li-chun Wei, Mei Shi, Guo-qing Wang, Chao-qun Wu, Qi-jun Kang, Jie Yang, Sha Li, Fei-yue Yang, Bao-gang Liu, Juan-yue Liu, Fan Shi, Jin Su, Wei Yuan, Emmanuel Kwateng Drokow

Open Access Case report

Ramsay-Hunt syndrome and subsequent sensory neuropathy as potential immune-related adverse events of nivolumab: a case report

Takashi Sakoh, Mami Kanzaki, Atsushi Miyamoto, Sayaka Mochizuki, Toshiyuki Kakumoto, Kenichiro Sato, Yoshikazu Uesaka, Kazuma Kishi

Open Access Research article

Differential diagnosis of pancreatic serous cystadenoma and mucinous cystadenoma: utility of textural features in combination with morphological characteristics

Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu, Xuelei Ma

Open Access Research article

ROS as a novel indicator to predict anticancer drug efficacy

Tarek Zaidieh, James R. Smith, Karen E. Ball, Qian An

Open Access Research article

A systematic analysis of immune genes and overall survival in cancer patients

Qian Wang, Pan Li, Weidong Wu

Open Access Correction

Correction to: Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz, Maria A. Ramos-Arroyo

Open Access Study protocol

SPAR – a randomised, placebo-controlled phase II trial of simvastatin in addition to standard chemotherapy and radiation in preoperative treatment for rectal cancer: an AGITG clinical trial

Michael B. Jameson, Kirsten Gormly, David Espinoza, Wendy Hague, Gholamreza Asghari, Grahame Mark Jeffery, Timothy Jay Price, Christos Stelios Karapetis, Michael Arendse, James Armstrong, John Childs, Frank A. Frizelle, Sam Ngan, Andrew Stevenson, Martinus Oostendorp, Stephen P. Ackland

Open Access Research article

Evaluation of gene-environment interactions for colorectal cancer susceptibility loci using case-only and case-control designs

Nan Song, Jeeyoo Lee, Sooyoung Cho, Jeongseon Kim, Jae Hwan Oh, Aesun Shin

Open Access Study protocol

The BE GONE trial study protocol: a randomized crossover dietary intervention of dry beans targeting the gut microbiome of overweight and obese patients with a history of colorectal polyps or cancer

Xiaotao Zhang, Gladys Browman, Wesley Siu, Karen M. Basen-Engquist, Samir M. Hanash, Kristi L. Hoffman, Pablo C. Okhuysen, Paul Scheet, Joseph F. Petrosino, Scott Kopetz, Carrie R. Daniel

Open Access Research article

The clinicopathologic features and prognosis of esophageal neuroendocrine carcinomas: a single-center study of 53 resection cases

Lei Ye, Heng Lu, Lin Wu, Lei Zhang, Hui Shi, Hui Min Wu, Pin Tu, De Min Li, Fang Yu Wang

Open Access Research article

Fertility-sparing surgery and oncologic outcome among patients with early-stage ovarian cancer ~propensity score- matched analysis~

Hiroaki Kajiyama, Shiro Suzuki, Nobuhisa Yoshikawa, Michiyasu Kawai, Kimio Mizuno, Osamu Yamamuro, Tetsuro Nagasaka, Kiyosumi Shibata, Fumitaka Kikkawa

Open Access Research article

Direct physical interaction of active Ras with mSIN1 regulates mTORC2 signaling

Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten, Smrati Bhadauria

Open Access Research article

Focused screening reveals functional effects of microRNAs differentially expressed in colorectal cancer

Danuta Sastre, João Baiochi, Ildercilio Mota de Souza Lima, Felipe Canto de Souza, Amanda Cristina Corveloni, Carolina Hassib Thomé, Vitor Marcel Faça, Josiane Lilian dos Santos Schiavinato, Dimas Tadeu Covas, Rodrigo Alexandre Panepucci

Open Access Research article

Causes of death in patients with locally advanced head and neck cancer treated with radiotherapy and systemic therapy

I. Zapata, M. Alvarez, R. Hidalgo, B. Pajares, M. J. Garcia-Anaya, M. D. Toledo, J. M. Trigo, Y. Lupiañez-Perez, J. A. Medina, J. Jaime Gomez-Millan

Open Access Research article

Non-destructive, label free identification of cell cycle phase in cancer cells by multispectral microscopy of autofluorescence

Jared M. Campbell, Abbas Habibalahi, Saabah Mahbub, Martin Gosnell, Ayad G. Anwer, Sharon Paton, Stan Gronthos, Ewa Goldys

Open Access Study protocol

The chemo-gut study: investigating the long-term effects of chemotherapy on gut microbiota, metabolic, immune, psychological and cognitive parameters in young adult Cancer survivors; study protocol

Julie M. Deleemans, Faye Chleilat, Raylene A. Reimer, Jan-Willem Henning, Mohamad Baydoun, Katherine-Ann Piedalue, Andrew McLennan, Linda E. Carlson

Open Access Research article

Accuracy of multiparametric magnetic resonance imaging for diagnosing prostate Cancer: a systematic review and meta-analysis

Liang Zhen, Xiaoqiang Liu, Chen Yegang, Yang Yongjiao, Xu Yawei, Kang Jiaqi, Wang Xianhao, Song Yuxuan, Hu Rui, Zhang Wei, Ou Ningjing

Open Access Research article

Microbial antigens-loaded myeloma cells enhance Th2 cell proliferation and myeloma clonogenicity via Th2–myeloma cell interaction

Faqing Tian, Bo Lu, Ziren Chen, Junru Liu, Delan Ji, Juheng Li, Meiqin Tang, Wei Zhu, Juan Li

Open Access Research article

AMAFRICA, a patient-navigator program for accompanying lymphoma patients during chemotherapy in Ivory Coast: a prospective randomized study

K. G. Koffi, D. A. Silué, C. Laurent, K. Boidy, S. Koui, G. Compaci, Z. H. Adeba, I. Kamara, R. P. Botty, A. S. Bognini, I. Sanogo, F. Despas, G. Laurent

Open Access Research article

A systematic review: comparative analysis of the effects of propofol and sevoflurane on postoperative cognitive function in elderly patients with lung cancer

Haitao Sun, Guohua Zhang, Bolun Ai, Huimin Zhang, Xiangyi Kong, Wan-Ting Lee, Hui Zheng, Tao Yan, Li Sun

Open Access Study protocol

A phase 2 study of trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway: TRAM-01

Sébastien Perreault, Valérie Larouche, Uri Tabori, Cynthia Hawkin, Sarah Lippé, Benjamin Ellezam, Jean-Claude Décarie, Yves Théoret, Marie-Élaine Métras, Serge Sultan, Édith Cantin, Marie-Ève Routhier, Maxime Caru, Geneviève Legault, Éric Bouffet, Lucie Lafay-Cousin, Juliette Hukin, Craig Erker, Nada Jabado

Open Access Research article

Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer

Daisuke Kotani, Yasutoshi Kuboki, Satoshi Horasawa, Asumi Kaneko, Yoshiaki Nakamura, Akihito Kawazoe, Hideaki Bando, Hiroya Taniguchi, Kohei Shitara, Takashi Kojima, Akihito Tsuji, Takayuki Yoshino

Open Access Correction

Correction to: Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly

Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong, Paul K. S. Chan

Open Access Research article

Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study

Laith N. AL-Eitan, Doaa M. Rababa’h, Mansour A. Alghamdi, Rame H. Khasawneh

Open Access Research article

An analysis about heterogeneity among cancers based on the DNA methylation patterns

Yang Liu, Yue Gu, Mu Su, Hui Liu, Shumei Zhang, Yan Zhang

Open Access Research article

Proposal for a definition of "Oligometastatic disease in pancreatic cancer"

Alexander I. Damanakis, Luisa Ostertag, Dirk Waldschmidt, Fabian Kütting, Alexander Quaas, Patrick Plum, Christiane J. Bruns, Florian Gebauer, Felix Popp

Open Access Research article

Risk of ischemic stroke in patients with prostate cancer receiving androgen deprivation therapy in Taiwan

Kuang-Ming Liao, Yaw-Bin Huang, Chung-Yu Chen, Chen-Chun Kuo

Open Access Research article

TOPK promotes metastasis of esophageal squamous cell carcinoma by activating the Src/GSK3β/STAT3 signaling pathway via γ-catenin

Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu, Ziming Dong

Open Access Research article

Androgen receptor and FOXA1 coexpression define a “luminal-AR” subtype of feline mammary carcinomas, spontaneous models of breast cancer

Elie Dagher, Violette Royer, Paul Buchet, Jérôme Abadie, Delphine Loussouarn, Mario Campone, Frédérique Nguyen

Open Access Research article

Elucidating the expression and function of Numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM)

Yuejiao Huang, Xianting Huang, Chun Cheng, Xiaohong Xu, Hong Liu, Xiaojing Yang, Li Yao, Zongmei Ding, Jie Tang, Song He, Yuchan Wang

Open Access Research article

Reliable cell and tissue morphology-based diagnosis of endemic Burkitt lymphoma in resource-constrained settings in Ghana

Cecilia Smith-Togobo, Mette Ø. Pedersen, Steffen G. Jensen, Babatunde Duduyemi, Richard K. Gyasi, Michael F. Ofori, Vivian Paintsil, Lorna Renner, Peter Nørgaard, Lars Hviid

Open Access Research article

Incidence of invasive breast cancer in women treated with testosterone implants: a prospective 10-year cohort study

Rebecca L. Glaser, Anne E. York, Constantine Dimitrakakis

Open Access Research article

Mammographic density is a potential predictive marker of pathological response after neoadjuvant chemotherapy in breast cancer

Ida Skarping, Daniel Förnvik, Hanna Sartor, Uffe Heide-Jørgensen, Sophia Zackrisson, Signe Borgquist

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