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Zeitschrift

BMC Cancer

BMC Cancer 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 1235 Artikel )

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High Oct4 expression: implications in the pathogenesis of neuroblastic tumours

Ezequiel Monferrer, Rebeca Burgos-Panadero, Maite Blanquer-Maceiras, Adela Cañete, Samuel Navarro, Rosa Noguera

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A phase II randomized controlled trial of three exercise delivery methods in men with prostate cancer on androgen deprivation therapy

Shabbir M. H. Alibhai, Daniel Santa Mina, Paul Ritvo, George Tomlinson, Catherine Sabiston, Murray Krahn, Sara Durbano, Andrew Matthew, Padraig Warde, Meagan O’Neill, Narhari Timilshina, Roanne Segal, Nicole Culos-Reed

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer

Taro Iwatsubo, Ryu Ishihara, Toshitaka Morishima, Akira Maekawa, Kentaro Nakagawa, Masamichi Arao, Masayasu Ohmori, Hiroyoshi Iwagami, Kenshi Matsuno, Shuntaro Inoue, Hiroko Nakahira, Noriko Matsuura, Satoki Shichijo, Takashi Kanesaka, Sachiko Yamamoto, Yoji Takeuchi, Koji Higashino, Noriya Uedo, Isao Miyashiro, Kazuhide Higuchi, Takashi Fujii

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prevalence of BRCA1 and BRCA2 pathogenic and likely pathogenic variants in non-selected ovarian carcinoma patients in Brazil

Deborah Porto Cotrim, Adriana Regina Gonçalves Ribeiro, Daniele Paixão, Diogo Cordeiro de Queiroz Soares, Rima Jbili, Natasha Carvalho Pandolfi, Camila Cezana, Carine de Cássia Mauro, Henrique Mantoan, Graziele Bovolim, Louise de Brot, Giovana Tardin Torrezan, Dirce Maria Carraro, Glauco Baiocchi, Maria Nirvana da Cruz Formiga, Alexandre A. B. A. da Costa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PET-CT has low specificity for mediastinal staging of non-small-cell lung cancer in an endemic area for tuberculosis: a diagnostic test study (LACOG 0114)

Gustavo Werutsky, Bruno Hochhegger, José Antônio Lopes de Figueiredo Pinto, Jeovany Martínez-Mesa, Mara Lise Zanini, Eduardo Herz Berdichevski, Eduardo Vilas, Vinícius Duval da Silva, Maria Teresa Ruiz Tsukazan, Arthur Vieira, Leandro Genehr Fritscher, Louise Hartmann, Marcos Alba, Guilherme Sartori, Cristina Matushita, Vanessa Bortolotto, Rayssa Ruszkowski do Amaral, Luís Carlos Anflor Junior, Facundo Zaffaroni, Carlos H. Barrios, Márcio Debiasi, Carlos Cezar Frietscher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation

Sang R. Lee, Sun Woo Kwon, Young Ho Lee, Pelin Kaya, Jong Min Kim, Changhwan Ahn, Eui-Man Jung, Geun-Shik Lee, Beum-Soo An, Eui-Bae Jeung, Bae-keun Park, Eui-Ju Hong

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A longitudinal mixed methods study on changes in body weight, body composition, and lifestyle in breast cancer patients during chemotherapy and in a comparison group of women without cancer: study protocol

J. Th. C. M. de Kruif, M. Visser, M. M. G. A. van den Berg, M. J. M. Derks, M. R. de Boer, H. W. M. van Laarhoven, J. H. M. de Vries, Y. C. de Vries, E. Kampman, R. W. Winkels, M. J. Westerman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Three-port single-intercostal versus multiple-intercostal thoracoscopic lobectomy for the treatment of lung cancer: a propensity-matched analysis

Zixiang Wu, Qi Wang, Cong Wu, Tianwei Zhan, Lingjun Dong, Shuai Fang, Xuyang Peng, Lian Wang, Saibo Pan, Ming Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Anti-cancer effect of dung beetle glycosaminoglycans on melanoma

Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jang Mi Jin, Hyung Joo Yoon, Jae Sam Hwang, Kun-Koo Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin

Min su You, Ji Kon Ryu, Young Hoon Choi, Jin Ho Choi, Gunn Huh, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mutation analysis by deep sequencing of pancreatic juice from patients with pancreatic ductal adenocarcinoma

Man Hung Choi, Eline Mejlænder-Andersen, Sophia Manueldas, Khadija El Jellas, Solrun J. Steine, Kjersti Tjensvoll, Hege Aase Sætran, Stian Knappskog, Dag Hoem, Oddmund Nordgård, Randi Hovland, Anders Molven

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Radium-223 in asymptomatic patients with castration-resistant prostate cancer and bone metastases treated in an international early access program

Axel Heidenreich, Silke Gillessen, Daniel Heinrich, Daniel Keizman, Joe M. O’Sullivan, Joan Carles, Manfred Wirth, Kurt Miller, John Reeves, Monica Seger, Sten Nilsson, Fred Saad

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Total hysterectomy versus uterine evacuation for preventing post-molar gestational trophoblastic neoplasia in patients who are at least 40 years old: a systematic review and meta-analysis

Peng Zhao, Yongchao Lu, Wei Huang, Baoqin Tong, Weiguo Lu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

miR-632 promotes gastric cancer progression by accelerating angiogenesis in a TFF1-dependent manner

Ying Shi, Xiaoxiao Huang, Guobin Chen, Ying Wang, Yuansheng Liu, Wei Xu, Shaohui Tang, Bayasi Guleng, Jingjing Liu, Jianlin Ren

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Decreased mean platelet volume predicts poor prognosis in metastatic colorectal cancer patients treated with first-line chemotherapy: results from mCRC biomarker study

Jinjia Chang, Guangyi Lin, Min Ye, Duo Tong, Jing Zhao, Dan Zhu, Qihe Yu, Wen Zhang, Wenhua Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between awareness of nutrition labeling and high-density lipoprotein cholesterol concentration in cancer survivors and the general population: The Korean National Health and Nutrition Examination Survey (KNHANES) 2010–2016

Ji Sung Yoo, Kyu-Tae Han, Seung Hyun Chung, Eun-Cheol Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patients with metastatic renal cell carcinoma who benefit from axitinib dose titration: analysis from a randomised, double-blind phase II study

Yoshihiko Tomita, Hirotsugu Uemura, Mototsugu Oya, Nobuo Shinohara, Tomonori Habuchi, Yosuke Fujii, Yoichi Kamei, Yoshiko Umeyama, Angel H. Bair, Brian I. Rini

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Randomized prospective phase III trial of 68Ga-PSMA-11 PET/CT molecular imaging for prostate cancer salvage radiotherapy planning [PSMA-SRT]

Jeremie Calais, Johannes Czernin, Wolfgang P. Fendler, David Elashoff, Nicholas G. Nickols

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differences in tumor microenvironments between primary lung tumors and brain metastases in lung cancer patients: therapeutic implications for immune checkpoint inhibitors

Ryul Kim, Bhumsuk Keam, Sehui Kim, Miso Kim, Se Hyun Kim, Jin Wook Kim, Yu Jung Kim, Tae Min Kim, Yoon Kyung Jeon, Dong-Wan Kim, Doo Hyun Chung, Jong Seok Lee, Dae Seog Heo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Shikonin inhibits cancer cell cycling by targeting Cdc25s

Shoude Zhang, Qiang Gao, Wei Li, Luwei Zhu, Qianhan Shang, Shuo Feng, Junmei Jia, Qiangqiang Jia, Shuo Shen, Zhanhai Su

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A modified subclassification to evaluate the survival of patients with N3 gastric cancer: an international database study

Man-Qiang Lin, Jia-Bin Wang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Qing-Liang He, Chang-Ming Huang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The clinicopathological features and treatment modalities associated with survival of neuroendocrine cervical carcinoma in a Chinese population

Xiaojing Zhang, Zunfu Lv, Hanmei Lou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Time trend of breast cancer mortality in BRAZILIAN men: 10-year data analysis from 2005 to 2015

Jean Henri Maselli-Schoueri, Fernando Alves Affonso-Kaufman, Claudia Vaz de Melo Sette, Francisco Winter dos Santos Figueiredo, Fernando Adami

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Interaction between TP53 and XRCC1 increases susceptibility to cervical cancer development: a case control study

Gui-Cen Liu, Yun-Fei Zhou, Xiao-Chao Su, Jun Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patient and carer perceived barriers to early presentation and diagnosis of lung cancer: a systematic review

Shemana Cassim, Lynne Chepulis, Rawiri Keenan, Jacquie Kidd, Melissa Firth, Ross Lawrenson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinicopathological features, treatment patterns, and prognosis of squamous cell carcinoma of the breast: an NCDB analysis

Liling Zhu, Kai Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting Ezh2 could overcome docetaxel resistance in prostate cancer cells

Xiaofu Qiu, Wei Wang, Bijun Li, Bo Cheng, Kangjian Lin, Jian Bai, Huanhui Li, Guosheng Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nab-paclitaxel and gemcitabine or FOLFIRINOX as first-line treatment in patients with unresectable adenocarcinoma of the pancreas: does sequence matter?

Ursula M. Vogl, Haleh Andalibi, Alexander Klaus, Laurenz Vormittag, Wolfgang Schima, Bettina Heinrich, Alice Kafka, Thomas Winkler, Leopold Öhler

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Ago HITS-CLIP expands microRNA-mRNA interactions in nucleus and cytoplasm of gastric cancer cells

Xinyi Zhang, Bo Shen, Yalei Cui

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα

He Xin, Chuanzhuo Wang, Zhaoyu Liu

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Invasive cystic hypersecretory carcinoma of the breast: a rare variant of breast cancer: a case report and review of the literature

Jie Sun, Xing Wang, Cuifang Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of mini-SSPedi for children 4–7 years of age receiving cancer treatments

Deborah Tomlinson, Shannon Hyslop, Eliana Stein, Brenda Spiegler, Emily Vettese, Susan Kuczynski, Tal Schechter, L. Lee Dupuis, Lillian Sung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk factors for surgical site infection after malignant bone tumor resection and reconstruction

Shinji Miwa, Toshiharu Shirai, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Kaoru Tada, Yoshitomo Kajino, Takashi Higuchi, Kensaku Abe, Hisaki Aiba, Yuta Taniguchi, Hiroyuki Tsuchiya

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development of a miRNA-seq based prognostic signature in lung adenocarcinoma

Chathura Siriwardhana, Vedbar S. Khadka, John J. Chen, Youping Deng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Single nucleotide polymorphism in the 3′ untranslated region of LPP is a risk factor for lung cancer: a case-control study

Shouchun Yan, Rong Sun, Shan Wu, Tianbo Jin, Shanshan Zhang, Fanglin Niu, Jingjie Li, Mingwei Chen

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Metastases to extraocular muscles from breast cancer: case report and up-to-date review of the literature

Marialuisa Framarino-dei-Malatesta, Annalisa Chiarito, Federico Bianciardi, Marco Fiorelli, Azzurra Ligato, Giuseppe Naso, Irene Pecorella

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of neutrophil-to-lymphocyte ratio in advanced nasopharyngeal carcinoma: a large institution-based cohort study from an endemic area

Ji-Jin Yao, Feng-Ting Zhu, Jun Dong, Zi-Bin Liang, Le-Wei Yang, Shao-Yi Chen, Wang-Jian Zhang, Wayne R. Lawrence, Fan Zhang, Si-Yang Wang, Ying Sun, Guan-Qun Zhou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

Patrick Sven Plum, Florian Gebauer, Max Krämer, Hakan Alakus, Felix Berlth, Seung-Hun Chon, Lars Schiffmann, Thomas Zander, Reinhard Büttner, Arnulf Heinrich Hölscher, Christiane Josephine Bruns, Alexander Quaas, Heike Loeser

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Geographical disparities in treatment and health care costs for end-of-life cancer patients in China: a retrospective study

Anli Leng, Jun Jing, Stephen Nicholas, Jian Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Real world evidence on gemcitabine and nab-paclitaxel combination chemotherapy in advanced pancreatic cancer

Hakon Blomstrand, Ursula Scheibling, Charlotte Bratthäll, Henrik Green, Nils O. Elander

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression of RET is associated with Oestrogen receptor expression but lacks prognostic significance in breast cancer

Robert Mechera, Savas D. Soysal, Salvatore Piscuoglio, Charlotte K. Y. Ng, Jasmin Zeindler, Edin Mujagic, Silvio Däster, Philippe Glauser, Henry Hoffmann, Ergin Kilic, Raoul A. Droeser, Walter P. Weber, Simone Muenst

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Disparities in breast cancer diagnosis for immigrant women in Ontario and BC: results from the CanIMPACT study

A. K. Lofters, M. L. McBride, D. Li, M. Whitehead, R. Moineddin, L. Jiang, E. Grunfeld, P. A. Groome, for the CanIMPACT Team

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparative efficacy and safety of combination therapies for advanced melanoma: a network meta-analysis

Qing An, Zhihao Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Sequential therapeutic targeting of ovarian Cancer harboring dysfunctional BRCA1

Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen, Walter H. Gotlieb

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Lymph node positivity in different early breast carcinoma phenotypes: a predictive model

Gilles Houvenaeghel, Eric Lambaudie, Jean-Marc Classe, Chafika Mazouni, Sylvia Giard, Monique Cohen, Christelle Faure, Hélène Charitansky, Roman Rouzier, Emile Daraï, Delphine Hudry, Pierre Azuar, Richard Villet, Pierre Gimbergues, Christine Tunon de Lara, Marc Martino, Jean Fraisse, François Dravet, Marie Pierre Chauvet, Jean Marie Boher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Trends in the incidence and mortality of transitional cell carcinoma of the bladder for the last four decades in the USA: a SEER-based analysis

Muneer J. Al-Husseini, Ahmad Kunbaz, Anas M. Saad, João Vasco Santos, Sami Salahia, Marium Iqbal, Fares Alahdab

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effects of subitems in the colorectal cancer screening protocol on the Chinese colorectal cancer screening program: an analysis based on natural community screening results

Shan-Rong Cai, Yan-Qin Huang, Su-Zhan Zhang, Qi-Rong Li, Xin Yuan Ma, Shu Zheng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

oipA “on” status of Helicobacter pylori is associated with gastric cancer in North-Eastern Brazil

Lúcia Libanez Bessa Campelo Braga, Maria Helane Rocha Batista, Orleâncio Gomes Ripardo de Azevedo, Kassiane Cristine da Silva Costa, Adriana Dias Gomes, Gifone Aguiar Rocha, Dulciene Maria Magalhães Queiroz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differential expression of TIM-3 between primary and metastatic sites in renal cell carcinoma

Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Kunpeng Shu, Jinge Zhao, Peng Zhao, Ni Chen, Jia Wang, Pengfei Shen, Hao Zeng

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

A rare BCR-ABL1 transcript in Philadelphia-positive acute myeloid leukemia: case report and literature review

Monica Piedimonte, Tiziana Ottone, Valentina Alfonso, Antonella Ferrari, Esmeralda Conte, Mariadomenica Divona, Maria Paola Bianchi, Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Alessia Campagna, Laura Cicconi, Giulia Galassi, Sabrina Pelliccia, Annapaola Leporace, Francesco Lo Coco, Agostino Tafuri

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Neutrophil-lymphocyte ratio as a predictor of oncologic outcomes in stage IVB, persistent, or recurrent cervical cancer patients treated by chemotherapy

Pornprom Ittiamornlert, Irene Ruengkhachorn

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review

Masanobu Abe, Kousuke Watanabe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Takahiro Abe, Yuko Fujihara, Yosuke Amano, Liang Zong, Cheng-Ping Wang, Emi Kubo, Ryoko Inaki, Naoya Kinoshita, Satoshi Yamashita, Daiya Takai, Toshikazu Ushijima, Takahide Nagase, Kazuto Hoshi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between male pattern baldness and testicular germ cell tumor: a meta-analysis

Jiatong Zhou, Shuai Xia, Tao Li, Ranlu Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Statin use and breast cancer survival – a Swedish nationwide study

Signe Borgquist, Per Broberg, Jasaman Tojjar, Håkan Olsson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Safety and efficacy of afatinib as add-on to standard therapy of gemcitabine/cisplatin in chemotherapy-naive patients with advanced biliary tract cancer: an open-label, phase I trial with an extensive biomarker program

Markus Moehler, Annett Maderer, Anne Ehrlich, Friedrich Foerster, Arno Schad, Tanja Nickolay, Christian Ruckes, Arndt Weinmann, Visvakanth Sivanathan, Jens U. Marquardt, Peter Robert Galle, Marcus Woerns, Thomas Thomaidis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Surrogacy of intermediate endpoints for overall survival in randomized controlled trials of first-line treatment for advanced soft tissue sarcoma in the pre- and post-pazopanib era: a meta-analytic evaluation

Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga, Hiroshi Tsumura

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Depletion of nuclear import protein karyopherin alpha 7 (KPNA7) induces mitotic defects and deformation of nuclei in cancer cells

Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen, Anne Kallioniemi

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Evaluation of effectiveness of the PlasmaJet surgical device in the treatment of advanced stage ovarian cancer (PlaComOv-study): study protocol of a randomized controlled trial in the Netherlands

G. M. Nieuwenhuyzen-de Boer, W. Hofhuis, N. Reesink-Peters, P. C. Ewing-Graham, I. G. Schoots, J. J. Beltman, J. M. J. Piek, A. Baalbergen, G. S. Kooi, A. van Haaften, H. van Huisseling, L. Haans, M. Dorman, H. J. van Beekhuizen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Optimal chemo-mobilization for the collection of peripheral blood stem cells in patients with multiple myeloma

Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Seung-Yeon Jung, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Abiraterone acetate plus prednisone for the Management of Metastatic Castration-Resistant Prostate Cancer (mCRPC) without prior use of chemotherapy: report from a large, international, real-world retrospective cohort study

Martin Boegemann, Sara Khaksar, Guillaume Bera, Alison Birtle, Catherine Dopchie, Louis-Marie Dourthe, Els Everaert, Martin Hatzinger, Dirko Hercher, Werner Hilgers, Geoffrey Matus, Laura Garcia Alvarez, Laurent Antoni, Martin Lukac, Geneviève Pissart, Paul Robinson, Tony Elliott

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Human papilloma virus and breast cancer: the role of inflammation and viral expressed proteins

Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad, Mohsen Moghoofei

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CYR61 triggers osteosarcoma metastatic spreading via an IGF1Rβ-dependent EMT-like process

Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda, Olivia Fromigué

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Medical oncology outpatients’ preferences and experiences with advanced care planning: a cross-sectional study

Amy Waller, Heidi Turon, Jamie Bryant, Alison Zucca, Tiffany-Jane Evans, Rob Sanson-Fisher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses

Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen, Joseph T. Chang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma

Emma Andersson Evelönn, Mattias Landfors, Zahra Haider, Linda Köhn, Börje Ljungberg, Göran Roos, Sofie Degerman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumor growth rate as a metric of progression, response, and prognosis in pancreatic and intestinal neuroendocrine tumors

Clarisse Dromain, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin, Martyn E. Caplin, on behalf of the CLARINET Study Group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identifying primary site of lung-limited Cancer of unknown primary based on relative gene expression orderings

Mengyao Li, Hongdong Li, Guini Hong, Zhongjie Tang, Guanghao Liu, Xiaofang Lin, Mingzhang Lin, Lishuang Qi, Zheng Guo

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma

Houda Bahig, Francine Aubin, John Stagg, Olguta Gologan, Olivier Ballivy, Eric Bissada, Felix-Phuc Nguyen-Tan, Denis Soulières, Louis Guertin, Edith Filion, Apostolos Christopoulos, Louise Lambert, Mustapha Tehfe, Tareck Ayad, Danielle Charpentier, Rahima Jamal, Philip Wong

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer

Andrea Rebeca Bustos-Carpinteyro, Carla Oliveira, Abel Sousa, Patricia Oliveira, Hugo Pinheiro, Joana Carvalho, María Teresa Magaña-Torres, María Guadalupe Flores-Miramontes, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Jorge Peregrina-Sandoval, José Alfonso Cruz-Ramos, Josefina Yoaly Sánchez-López

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Long term follow-up of neoadjuvant chemotherapy for non-small cell lung cancer (NSCLC) investigating early positron emission tomography (PET) scan as a predictor of outcome

Perrin E. Romine, Renato G. Martins, Keith D. Eaton, Douglas E. Wood, Fatemeh Behnia, Bernardo H. L. Goulart, Michael S. Mulligan, Sarah G. Wallace, Elizabeth Kell, Julie E. Bauman, Shilpen A. Patel, Hubert J. Vesselle

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association of uPA and PAI-1 tumor levels and 4G/5G variants of PAI-1 gene with disease outcome in luminal HER2-negative node-negative breast cancer patients treated with adjuvant endocrine therapy

Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević, Tatjana Stanojković

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma – correlation with clinicopathological data and comparison of antibodies

Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss, Benjamin Goeppert

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pretreatment thrombocytosis predict poor prognosis in patients with endometrial carcinoma: a systematic review and meta-analysis

Dan Nie, E. Yang, Zhengyu Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serum Hepcidin and GDF-15 levels as prognostic markers in urothelial carcinoma of the upper urinary tract and renal cell carcinoma

Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader, Andrea U. Steinbicker

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Rationale and design of the Caloric Restriction and Exercise protection from Anthracycline Toxic Effects (CREATE) study: a 3-arm parallel group phase II randomized controlled trial in early breast cancer

Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John R. Mackey, Kerry S. Courneya, Edith Pituskin, Richard B. Thompson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CD1d- and PJA2-related immune microenvironment differs between invasive breast carcinomas with and without a micropapillary feature

Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi, Takuya Moriya

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

Zehui Li, Nneka E. Mbah, Jean H. Overmeyer, Jeffrey G. Sarver, Sage George, Christopher J. Trabbic, Paul W. Erhardt, William A. Maltese

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Estrogen receptor signaling regulates the expression of the breast tumor kinase in breast cancer cells

Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson, Kiven Erique Lukong

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Alterations in the glycome after HDAC inhibition impact oncogenic potential in epigenetically plastic SW13 cells

McKale R. Montgomery, Elizabeth E. Hull

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Different prognostic implication of ypTNM stage and pTNM stage for gastric cancer: a propensity score-matched analysis

Ziyu Li, Yinkui Wang, Xiangji Ying, Fei Shan, Zhouqiao Wu, Lianhai Zhang, Shuangxi Li, Yongning Jia, Hui Ren, Jiafu Ji

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Age-related changes in the BACH2 and PRDM1 genes in lymphocytes from healthy donors and chronic lymphocytic leukemia patients

Vu Luan Dang Chi, Soizic Garaud, Pushpamali De Silva, Vincent Thibaud, Basile Stamatopoulos, Mimoune Berehad, Chunyan Gu-Trantien, Mohammad Krayem, Hugues Duvillier, Jean-Nicolas Lodewyckx, Karen Willard-Gallo, Catherine Sibille, Dominique Bron

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer-related concerns and needs among young adults and children on cancer treatment in Tanzania: a qualitative study

Thecla W. Kohi, Louise von Essen, Golden M. Masika, Maria Gottvall, Justine Dol

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome

Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan, Adam A. Sabile

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Does guideline non-adherence result in worse clinical outcomes for hormone receptor-positive and HER2-negative metastatic breast cancer in premenopausal women?: result of an institution database from South Korea

Hee Kyung Kim, Soo-Hyeon Lee, Yu Jin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu, Yeon Hee Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases

Justyna Sikorska, Damian Gaweł, Hanna Domek, Magdalena Rudzińska, Barbara Czarnocka

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Obesity impacts the regulation of miR-10b and its targets in primary breast tumors

Ari Meerson, Yaniv Eliraz, Hila Yehuda, Bridget Knight, Malcolm Crundwell, Douglas Ferguson, Benjamin P. Lee, Lorna W. Harries

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Free testosterone value before radical prostatectomy is related to oncologic outcomes and post-operative erectile function

Tian Li, Xiangzhou Sun, Liheng Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Epidemiological characteristics, clinical outcomes and management patterns of metastatic breast cancer patients in routine clinical care settings of Greece: Results from the EMERGE multicenter retrospective chart review study

Athanasios Kotsakis, Alexandros Ardavanis, Georgios Koumakis, Epameinondas Samantas, Amanta Psyrri, Christos Papadimitriou

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A randomized controlled trial of a group acceptance-based intervention for cancer survivors experiencing anxiety at re-entry (‘Valued Living’): study protocol

Joanna J. Arch, Jill L. Mitchell, Sarah R. Genung, Robert Fisher, David J. Andorsky, Annette L. Stanton

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Does the number of removed axillary lymphnodes in high risk breast cancer patients influence the survival?

Florian Ebner, Achim Wöckel, Lukas Schwentner, Maria Blettner, Wolfgang Janni, Rolf Kreienberg, Manfred Wischnewsky

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Feasibility and validity of The Health Improvement Network database of primary care electronic health records to identify and characterise patients with small cell lung cancer in the United Kingdom

Lucía Cea Soriano, Jihong Zong, Luis A. García Rodríguez

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identifying optimal candidates for local treatment of the primary tumor among patients with de novo metastatic nasopharyngeal carcinoma: a retrospective cohort study based on Epstein–Barr virus DNA level and tumor response to palliative chemotherapy

Xue-Song Sun, Li-Ting Liu, Sai-Lan Liu, Shan-Shan Guo, Yue-Feng Wen, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Jun Ma, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients

Daniel Castellano-Castillo, Sonsoles Morcillo, Ana B. Crujeiras, Lidia Sánchez-Alcoholado, Mercedes Clemente-Postigo, Esperanza Torres, Francisco José Tinahones, Manuel Macias-Gonzalez

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice

Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma, Jian Lu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis

Xin Yin, Danfang Yan, Miao Qiu, Liming Huang, Sen-Xiang Yan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CCNE1 amplification is associated with poor prognosis in patients with triple negative breast cancer

Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang, Yuan Yuan

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Randomized prospective phase III trial of 68Ga-PSMA-11 PET/CT molecular imaging for prostate cancer salvage radiotherapy planning [PSMA-SRT]

Jeremie Calais, Johannes Czernin, Wolfgang P. Fendler, David Elashoff, Nicholas G. Nickols

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Multimodal prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first international randomized controlled trial for multimodal prehabilitation

Stefanus van Rooijen, Francesco Carli, Susanne Dalton, Gwendolyn Thomas, Rasmus Bojesen, Morgan Le Guen, Nicolas Barizien, Rashami Awasthi, Enrico Minnella, Sandra Beijer, Graciela Martínez-Palli, Rianne van Lieshout, Ismayil Gögenur, Carlo Feo, Christoffer Johansen, Celena Scheede-Bergdahl, Rudi Roumen, Goof Schep, Gerrit Slooter

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effect of topical microporous polysaccharide hemospheres on the duration and amount of fluid drainage following mastectomy: a prospective randomized clinical trial

Lorena P. Suarez-Kelly, W. Hampton Pasley, Eric J. Clayton, Stephen P. Povoski, William E. Carson, Ray Rudolph

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A comprehensive study of risk factors for post-operative pneumonia following resection of meningioma

M. R. Zuo, R. F. Liang, M. Li, Y. F. Xiang, S. X. Zhang, Y. Yang, X. Wang, Q. Mao, Y. H. Liu

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: inhibition of p38 MAPK activity leads to cell type-specific effects on the molecular circadian clock and time-dependent reduction of glioma cell invasiveness

Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest, Deborah Bell-Pedersen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer

Nuramalina H. Mumin, Neele Drobnitzky, Agata Patel, Luiza Madia Lourenco, Fiona F. Cahill, Yanyan Jiang, Anthony Kong, Anderson J. Ryan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cell cycle, energy metabolism and DNA repair pathways in cancer cells are suppressed by Compound Kushen Injection

Jian Cui, Zhipeng Qu, Yuka Harata-Lee, Thazin Nwe Aung, Hanyuan Shen, Wei Wang, David L. Adelson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells

Zheqing Cui, Yulin Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact on prognosis of rebiopsy in advanced non-small cell lung cancer patients after epidermal growth factor receptor-tyrosine kinase inhibitor treatment: a systematic review

Takuma Imakita, Hirotaka Matsumoto, Katsuya Hirano, Toshiyuki Morisawa, Azusa Sakurai, Yuki Kataoka

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Droplet digital PCR as an alternative to FISH for MYCN amplification detection in human neuroblastoma FFPE samples

Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman, Natarajan Aravindan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

On the use of flexible excess hazard regression models for describing long-term breast cancer survival: a case-study using population-based cancer registry data

R. Schaffar, A. Belot, B. Rachet, L. Woods

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid, Fabian D. Mairinger

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia

Yao Xue, Yuqiu Ge, Meiyun Kang, Cong Wu, Yaping Wang, Liucheng Rong, Yongjun Fang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic value of the Tau protein serum level in metastatic breast cancer patients and its correlation with brain metastases

Amélie Darlix, Christophe Hirtz, Simon Thezenas, Aleksandra Maceski, Audrey Gabelle, Evelyne Lopez-Crapez, Hélène De Forges, Nelly Firmin, Séverine Guiu, William Jacot, Sylvain Lehmann

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Human papillomavirus genotype distribution and socio-behavioural characteristics in women with cervical pre-cancer and cancer at the start of a human papillomavirus vaccination programme: the CIN3+ plus study

Dianne Egli-Gany, Anne Spaar Zographos, Joachim Diebold, Virginie Masserey Spicher, Brigitte Frey Tirri, Rolf Heusser, Joakim Dillner, Patrick Petignat, Roland Sahli, Nicola Low, on behalf of the CIN3+plus study group

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy

Jing Ye, Xiao-dong Cheng, Bei Cheng, Yi-fan Cheng, Xiao-Jing Chen, Wei-guo Lu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review

Ersilia Lucenteforte, Alfredo Vannacci, Giada Crescioli, Niccolò Lombardi, Laura Vagnoli, Laura Giunti, Valentina Cetica, Maria Luisa Coniglio, Alessandra Pugi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Roberto Barale, Lisa Giovannelli, Alessandro Mugelli, Valentina Maggini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients

Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Predictors for use of psychosocial services in patients with metastatic colorectal cancer receiving first line systemic treatment

Claudia S. E. W. Schuurhuizen, Annemarie M. J. Braamse, Inge R. H. M. Konings, Henk M. W. Verheul, Joost Dekker

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature

Taketsugu Fujibuchi, Joji Miyawaki, Teruki Kidani, Hiroshi Imai, Hiroshi Kiyomatsu, Riko Kitazawa, Hiromasa Miura

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme

Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell, Dieter Henrik Heiland

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population

Lenny N. Gallardo-Alvarado, María Teresa Tusié-Luna, María Isabel Tussié-Luna, José Díaz-Chávez, Yayoi X. Segura, Enrique Bargallo-Rocha, Cynthia Villarreal, Luis A. Herrera-Montalvo, Enrique M. Herrera-Medina, David F. Cantu-de Leon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of in vitro driven expression signatures of CD133 stem cell marker and tumor stroma on clinical outcomes in gastric cancers

Tae-Min Kim, Yoon Ho Ko, Shin Jung Ha, Han Hong Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer

Lisa König, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer, Agnes Bankfalvi

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)

Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy Maughan, Somnath Mukherjee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy

Zsuzsanna Kahan, Daniela Grecea, Martin Smakal, Sergei Tjulandin, Igor Bondarenko, Luca Perjesi, Andras Illes, Karoly Horvat-Karajz, Ildiko Aradi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis

Zhao-Wen Luo, Ming-Gu Zhu, Zhi-Qiao Zhang, Feng-Jun Ye, Wen-Heng Huang, Xue-Zhang Luo

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy

Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini, Charles-Henry Rochat

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial

Mami Ogita, Kenji Sekiguchi, Keiko Akahane, Ryoko Ito, Chiori Haga, Satoru Arai, Yasushi Ishida, Jiro Kawamori

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis

Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini, Pier-Luigi Lollini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumor classification and biomarker discovery based on the 5’isomiR expression level

Shengqin Wang, Zhihong Zheng, Peichao Chen, Mingjiang Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model

Lu Wang, Liyuan Liu, Zhen Lou, Lijie Ding, Hui Guan, Fei Wang, Lixiang Yu, Yujuan Xiang, Fei Zhou, Fuzhong Xue, Zhigang Yu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs

Hong Liu, Pei-wu Li, Wei-qin Yang, Hong Mi, Jing-lin Pan, Yuan-cheng Huang, Zheng-kun Hou, Qiu-ke Hou, Qi Luo, Feng-bin Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Breaking silence: a survey of barriers to goals of care discussions from the perspective of oncology practitioners

Katrina Lynn Piggott, Ameen Patel, Arthur Wong, Leslie Martin, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind, John J. You

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation after AZD9291 treatment: a case report

Junhui Wang, Jianxin Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy

Alex Molassiotis, Hui Lin Cheng, Violeta Lopez, Joseph S. K. Au, Alexandre Chan, Aishwarya Bandla, K. T. Leung, Y. C. Li, K. H. Wong, Lorna K. P. Suen, Choi Wan Chan, Janelle Yorke, Carole Farrell, Raghav Sundar

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas, Yildiz E. Yilmaz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials

Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Amélie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Marianne Paesmans, Alain Hendlisz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy

Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad, Mohamed Al Bashir

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Encapsulated miR-200c and Nkx2.1 in a nuclear/mitochondria transcriptional regulatory network of non-metastatic and metastatic lung cancer cells

Olga D’Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine, Jean-Bosco Tagne

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer-associated fibroblasts induce epithelial–mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling

Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot, Stéphane Bolduc

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis

Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T. Y. Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong, Paul K. S. Chan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Incidence of childhood CNS tumours in Britain and variation in rates by definition of malignant behaviour: population-based study

Charles A. Stiller, Anita M. Bayne, Aruna Chakrabarty, Tom Kenny, Paul Chumas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cost-effectiveness of bevacizumab plus paclitaxel versus paclitaxel for the first-line treatment of HER2-negative metastatic breast cancer in specialist oncology centers in France

Audrey Petitjean, Jayne Smith-Palmer, William Valentine, Bertrand Tehard, Stephané Roze

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hematologic markers of distant metastases and poor prognosis in gynecological cancers

O. Abu-Shawer, M. Abu-Shawer, N. Hirmas, A. Alhouri, A. Massad, B. Alsibai, H. Sultan, H. Hammo, M. Souleiman, Y. Shebli, M. Al-Hussaini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort

Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt, Torben F. Hansen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases

Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang, Xiaohua Liang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus

Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng, Jianzhong Shou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: a systematic review and meta-analysis

Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Sleep disorders associated with risk of prostate cancer: a population-based cohort study

Wei-Sheng Chung, Cheng-Li Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up

Yang Guang, Wen He, Yukun Luo, Hongxia Zhang, Yukang Zhang, Bin Ning, Tengfei Yu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation

Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim, Seung Joon Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice

Young-Cheol Lim, Hyeongi Kim, Sang Moo Lim, Jin Su Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study

Omar F. Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J. Ko, Haocheng Li, Aalok Kumar, Michael M. Vickers, Patricia A. Tang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice

Derek Weycker, Mark Hatfield, Aaron Grossman, Ahuva Hanau, Alex Lonshteyn, Anjali Sharma, David Chandler

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study

Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart, Max J. Henderson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells

Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro, Wenyi Gu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center

Nooria Atta, Saadettin Kilickap, Deniz Yuce, Mutlu Hayran

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients

Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert, Matthias Kappler

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients

Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshiaki Kawamura, Yuki Shimizu, Toshiro Terachi, Motohiko Sugi, Hidefumi Kinoshita, Tadashi Matsuda, Yusuke Yamada, Shingo Yamamoto, Hiromi Hirama, Mikio Sugimoto, Yoshiyuki Kakehi, Toshihiko Sakurai, Norihiko Tsuchiya

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton, Sebastian G. B. Furness

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro

Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha, Patrick E. Chappell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Stromal cell ratio based on automated image analysis as a predictor for platinum-resistant recurrent ovarian cancer

C. Lan, J. Li, X. Huang, A. Heindl, Y. Wang, S. Yan, Y. Yuan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer

Elisabeth C. W. Neefjes, Maurice J. D. L. van der Vorst, Manon S. A. Boddaert, Bea A. T. T. Verdegaal, Aart Beeker, Saskia C. C. Teunissen, Aartjan T. F. Beekman, Wouter W. A. Zuurmond, Johannes Berkhof, Henk M. W. Verheul

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location

Robin Mjelle, Wenche Sjursen, Liv Thommesen, Pål Sætrom, Eva Hofsli

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma after curative resection: a case report

Lingmin Song, Yangmin Wang, Guobin Weng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Efficacy and risk of cytotoxic chemotherapy in extensive disease-small cell lung cancer patients with interstitial pneumonia

Masayuki Shirasawa, Tomoya Fukui, Seiichiro Kusuhara, Yasuhiro Hiyoshi, Yoshiro Nakahara, Noriko Nishinarita, Satoshi Igawa, Katsuhiko Naoki

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Blood groups A and AB are associated with increased gastric cancer risk: evidence from a large genetic study and systematic review

Yingying Mao, Wenjun Yang, Qi Qi, Fei Yu, Tianpei Wang, Hongfei Zhang, Juncheng Dai, Hongxia Ma, Zhibin Hu, Hongbing Shen, Gang Li, Guangfu Jin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Fasting plasma glucose is an independent predictor of survival in patients with locally advanced non-small cell lung cancer treated with concurrent chemoradiotherapy

Milana Bergamino, Antonio J. Rullan, Maria Saigí, Inmaculada Peiró, Eduard Montanya, Ramón Palmero, José Carlos Ruffinelli, Arturo Navarro, María Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Felipe Cardenal, Ernest Nadal

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Are rare cancer survivors at elevated risk of subsequent new cancers?

Dianne M. Finkelstein, Nora K. Horick, Ritesh Ramchandani, Kristina L. Boyd, Huma Q. Rana, Brittany L. Bychkovsky

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging

Anne Laprie, Soléakhéna Ken, Thomas Filleron, Vincent Lubrano, Laure Vieillevigne, Fatima Tensaouti, Isabelle Catalaa, Sergio Boetto, Jonathan Khalifa, Justine Attal, Guillaume Peyraga, Carlos Gomez-Roca, Emmanuelle Uro-Coste, Georges Noel, Gilles Truc, Marie-Pierre Sunyach, Nicolas Magné, Marie Charissoux, Stéphane Supiot, Valérie Bernier, Muriel Mounier, Muriel Poublanc, Amandine Fabre, Jean-Pierre Delord, Elizabeth Cohen-Jonathan Moyal

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of performance status in metastatic renal cell carcinoma patients receiving tyrosine kinase inhibitors: a systematic review and meta-analysis

Yawei Xu, Yuanyuan Zhang, Xianhao Wang, Jiaqi Kang, Xiaoqiang Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Chronological occurrence of PI3KCA mutations in breast cancer liver metastases after repeat partial liver resection

Aldrick Ruiz, Mylène Sebagh, Raphaël Saffroy, Marc-Antoine Allard, Nelly Bosselut, Giulia Hardoin, Julie Vasseur, Jocelyne Hamelin, René Adam, Jean-François Morère, Antoinette Lemoine

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review

Mohammad A. Al Hamad, Hassan M. Albisher, Weam R. Al Saeed, Ahmed T. Almumtin, Fatimah M. Allabbad, Mohammed A. Shawarby

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MUC16 impacts tumor proliferation and migration through cytoplasmic translocation of P120-catenin in epithelial ovarian cancer cells: an original research

Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu, Xipeng Wang

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Diffuse cavernous hemangioma of the skull misdiagnosed as skull metastasis in breast cancer patient: one case report and literature review

Huizhi Liu, Xiaojing Chang, Hua Shang, Feng Li, Huandi Zhou, Xiaoying Xue

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases

Rainer J. Klement, N. Abbasi-Senger, S. Adebahr, H. Alheid, M. Allgaeuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, M. J. Eble, I. Ernst, S. Gerum, D. Habermehl, P. Hass, C. Henkenberens, G. Hildebrandt, D. Imhoff, H. Kahl, N. D. Klass, R. Krempien, V. Lewitzki, F. Lohaus, C. Ostheimer, A. Papachristofilou, C. Petersen, J. Rieber, T. Schneider, E. Schrade, R. Semrau, S. Wachter, A. Wittig, M. Guckenberger, N. Andratschke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Usefulness of hemoglobin A1c and glycated albumin measurements for insulinoma screening: an observational case-control study

Keiichi Torimoto, Yosuke Okada, Yoshiya Tanaka, Atsuko Matsuoka, Yushi Hirota, Wataru Ogawa, Yoshifumi Saisho, Isao Kurihara, Hiroshi Itoh, Shinya Inada, Masafumi Koga

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Kei Namba, Shuta Tomida, Takehiro Matsubara, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Takahiro Yoshioka, Tatsuaki Takeda, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Zoledronic acid blocks the interaction between breast cancer cells and regulatory T-cells

Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen, Tsun-Mei Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Appraising growth differentiation factor 15 as a promising biomarker in digestive system tumors: a meta-analysis

Yanqiu Wang, Tao Jiang, Mingyan Jiang, Shuijing Gu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Competing risk analyses of overall survival and cancer-specific survival in patients with combined hepatocellular cholangiocarcinoma after surgery

Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Time dependent response of daunorubicin on cytotoxicity, cell cycle and DNA repair in acute lymphoblastic leukaemia

Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews, Christopher Bradley

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Metachronous metastasis to inguinal lymph nodes from sigmoid colon adenocarcinoma with abdominal wall metastasis: a case report

Taro Tanabe, Dai Shida, Shunsuke Tsukamoto, Goki Morizono, Hirokazu Taniguchi, Yukihide Kanemitsu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study

Hong Ji, Le Lu, Jingjing Huang, Yang Liu, Binchao Zhang, Hui Tang, Dangze Sun, Yafei Zhang, Hao Shang, Yiming Li, Hongwei Lu

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Primary paediatric epidural sarcomas: molecular exploration of three cases

Sharon Y. Y. Low, Chik Hong Kuick, Wan Yi Seow, Nurfahanah Bte Syed Sulaiman, Huiyi Chen, Derrick W. Q. Lian, Kenneth T. E. Chang, Enrica E. K. Tan, Shui Yen Soh, Grace I. L. Tan, Lee Ping Ng, Wan Tew Seow, David C. Y. Low

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

VEGFR2 promotes tumorigenesis and metastasis in a pro-angiogenic-independent way in gastric cancer

Lian Lian, Xiang-Li Li, Meng-Dan Xu, Xian-Min Li, Meng-Yao Wu, Yan Zhang, Min Tao, Wei Li, Xiao-Ming Shen, Chong Zhou, Min Jiang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A systematic review and meta-analysis of the prevalence of thrombosis and bleeding at diagnosis of Philadelphia-negative myeloproliferative neoplasms

Tarinee Rungjirajittranon, Weerapat Owattanapanich, Patompong Ungprasert, Noppadol Siritanaratkul, Theera Ruchutrakool

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Molecular Pathogenesis of Cholangiocarcinoma

Peter L. Labib, George Goodchild, Stephen P. Pereira

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Pneumatosis intestinalis induced by osimertinib in a patient with lung adenocarcinoma harbouring epidermal growth factor receptor gene mutation with simultaneously detected exon 19 deletion and T790 M point mutation: a case report

Yuki Nukii, Atsushi Miyamoto, Sayaka Mochizuki, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Shigeo Hanada, Hironori Uruga, Hisashi Takaya, Nasa Morokawa, Kazuma Kishi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic relevance of FOXA1 and Nestin expression in breast cancer metastases: a retrospective study of 164 cases during a 10-year period (2004–2014)

Shahin De Lara, Jenny Nyqvist, Elisabeth Werner Rönnerman, Khalil Helou, Elisabeth Kenne Sarenmalm, Zakaria Einbeigi, Per Karlsson, Toshima Z. Parris, Anikó Kovács

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A high throughput screening system of coils for ELF magnetic fields experiments: proof of concept on the proliferation of cancer cell lines

Leonardo Makinistian, Eva Marková, Igor Belyaev

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas

Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li, Juanjuan Xiang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The contribution of the rs55705857 G allele to familial cancer risk as estimated in the Utah population database

Sarah Hummel, Wendy Kohlmann, Thomas M. Kollmeyer, Robert Jenkins, Joshua Sonnen, Cheryl A. Palmer, Howard Colman, Diana Abbott, Lisa Cannon-Albright, Adam L. Cohen

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Diagnosis and treatment complications of primary cardiac lymphoma in an immunocompetent 28-year old man: a case report

Maria Bonou, Chris J. Kapelios, Athanasios Marinakos, Stamatis Adamopoulos, Panagiotis Diamantopoulos, Periklis G. Foukas, Loukas Kaklamanis, Penelope Korkolopoulou, John Barbetseas, Nora-Athina Viniou

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas

Anne-Katrin Hickmann, Maximilian Frick, Dirk Hadaschik, Florian Battke, Markus Bittl, Oliver Ganslandt, Saskia Biskup, Dennis Döcker

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer

Cornelia Schroeder, Jan Grell, Claudia Hube-Magg, Martina Kluth, Dagmar Lang, Ronald Simon, Doris Höflmayer, Sarah Minner, Eike Burandt, Till S. Clauditz, Franziska Büscheck, Frank Jacobsen, Hartwig Huland, Markus Graefen, Thorsten Schlomm, Guido Sauter, Stefan Steurer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Modeling to capture bystander-killing effect by released payload in target positive tumor cells

Jong Hyuk Byun, Il Hyo Jung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The heart’s exposure to radiation increases the risk of cardiac toxicity after chemoradiotherapy for superficial esophageal cancer: a retrospective cohort study

Yoshito Hayashi, Hideki Iijima, Fumiaki Isohashi, Yoshiki Tsujii, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Tomoki Makino, Makoto Yamasaki, Kazuhiko Ogawa, Yuichiro Doki, Tetsuo Takehara

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Safety and antitumor activity of the anti–PD-1 antibody pembrolizumab in patients with advanced, PD-L1–positive papillary or follicular thyroid cancer

Janice M. Mehnert, Andrea Varga, Marcia S. Brose, Rahul R. Aggarwal, Chia-Chi Lin, Amy Prawira, Filippo de Braud, Kenji Tamura, Toshihiko Doi, Sarina A. Piha-Paul, Jill Gilbert, Sanatan Saraf, Pradeep Thanigaimani, Jonathan D. Cheng, Bhumsuk Keam

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy

Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas, Jaunius Urbonavičius

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Phase I/IIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol

Paul Lesueur, Justine Lequesne, Jean-Michel Grellard, Audrey Dugué, Elodie Coquan, Pierre-Emmanuel Brachet, Julien Geffrelot, William Kao, Evelyne Emery, David Hassanein Berro, Laurent Castera, Nicolas Goardon, Joëlle Lacroix, Marie Lange, Aurélie Capel, Alexandra Leconte, Benoit Andre, Angélique Léger, Anaïs Lelaidier, Bénédicte Clarisse, Dinu Stefan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The effect of length of birth interval on the risk of breast cancer by subtype in grand multiparous women

Sushmita Katuwal, Juha S. Tapanainen, Eero Pukkala, Antti Kauppila

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The neoepitope landscape of breast cancer: implications for immunotherapy

Pooja Narang, Meixuan Chen, Amit A. Sharma, Karen S. Anderson, Melissa A. Wilson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The imbalance in the complement system and its possible physiological mechanisms in patients with lung cancer

Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou, Muying Ying

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combined Casein Kinase II inhibition and epigenetic modulation in acute B-lymphoblastic leukemia

Anna Richter, Catrin Roolf, Mohamed Hamed, Yvonne Saara Gladbach, Sina Sender, Christoph Konkolefski, Gudrun Knübel, Anett Sekora, Georg Fuellen, Brigitte Vollmar, Hugo Murua Escobar, Christian Junghanss

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Challenges of driving CD30-directed CAR-T cells to the clinic

Natalie S. Grover, Barbara Savoldo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PPARγ activation serves as therapeutic strategy against bladder cancer via inhibiting PI3K-Akt signaling pathway

Shidong Lv, Wei Wang, Hongyi Wang, Yongtong Zhu, Chengyong Lei

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model

Margarite D. Matossian, Hope E. Burks, Steven Elliott, Van T. Hoang, Annie C. Bowles, Rachel A. Sabol, Bahia Wahba, Muralidharan Anbalagan, Brian Rowan, Mohamed E. Abazeed, Bruce A. Bunnell, Krzysztof Moroz, Lucio Miele, Lyndsay V. Rhodes, Steven D. Jones, Elizabeth C. Martin, Bridgette M. Collins-Burow, Matthew E. Burow

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A multi-center prospective randomized controlled trial (phase III) comparing the quality of life between laparoscopy-assisted distal gastrectomy and totally laparoscopic distal gastrectomy for gastric Cancer (study protocol)

Chang Min Lee, Ji Ho Park, Chang In Choi, Han Hong Lee, Jae-Seok Min, Ye Seob Jee, Oh. Jeong, Hyundong Chae, Sung Il Choi, Hua Huang, Sungsoo Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Eosinophil-cationic protein - a novel liquid prognostic biomarker in melanoma

Annika Krückel, Alvaro Moreira, Waltraud Fröhlich, Gerold Schuler, Lucie Heinzerling

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Meng Sha, Seogsong Jeong, Xin Wang, Ying Tong, Jie Cao, Han-Yong Sun, Lei Xia, Ning Xu, Zhi-Feng Xi, Jian-Jun Zhang, Xiao-Ni Kong, Qiang Xia

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MicroRNA-148b regulates tumor growth of non-small cell lung cancer through targeting MAPK/JNK pathway

Lin Lu, Qiyao Liu, Peipei Wang, Yong Wu, Xia Liu, Chengyin Weng, Xisheng Fang, Baoxiu Li, Xiaofei Cao, Haibo Mao, Lina Wang, Mingmei Guan, Wei Wang, Guolong Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development and validation of case-finding algorithms for recurrence of breast cancer using routinely collected administrative data

Yuan Xu, Shiying Kong, Winson Y. Cheung, Antoine Bouchard-Fortier, Joseph C. Dort, Hude Quan, Elizabeth M. Buie, Geoff McKinnon, May Lynn Quan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Increased NHE1 expression is targeted by specific inhibitor cariporide to sensitize resistant breast cancer cells to doxorubicin in vitro and in vivo

Qi Chen, Yueqin Liu, Xiao-lan Zhu, Fan Feng, Hui Yang, Wenlin Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Epidemiological, clinical and pathological characteristics of gastric neoplasms in the province of Cremona: the experience of the first population-based specialized gastric cancer registry in Italy

B. M. Donida, G. Tomasello, M. Ghidini, F. Buffoli, M. Grassi, W. Liguigli, G. Maglietta, L. Pergola, M. Ratti, G. Sabadini, L. Toppo, M. Ungari, R. Passalacqua

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High Beclin-1 and ARID1A expression corelates with poor survival and high recurrence in intrahepatic cholangiocarcinoma: a histopathological retrospective study

Chao Bi, Mei Liu, Weiqi Rong, Fan Wu, Yang Zhang, Shengtao Lin, Yunhe Liu, Jianxiong Wu, Liming Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cost burden associated with advanced non-small cell lung cancer in Europe and influence of disease stage

Robert Wood, Gavin Taylor-Stokes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Quantification of intrinsic subtype ambiguity in Luminal A breast cancer and its relationship to clinical outcomes

Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi, Peter H. Gann

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combination of lymphovascular invasion and the AJCC TNM staging system improves prediction of prognosis in N0 stage gastric cancer: results from a high-volume institution

Jun Lu, Yun Dai, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review

Congcong Li, Qing Zhang, Siying Zhang, Ruifen Dong, Chenggong Sun, Chunping Qiu, Zhiwei Zhang, Xingsheng Yang, Beihua Kong

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Self-monitoring and reminder text messages to increase physical activity in colorectal cancer survivors (Smart Pace): a pilot randomized controlled trial

Erin L. Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A. Kenfield, June M. Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe E. Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A. Meyerhardt, Alan P. Venook

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Roadmap of DNA methylation in breast cancer identifies novel prognostic biomarkers

Bernardo P. de Almeida, Joana Dias Apolónio, Alexandra Binnie, Pedro Castelo-Branco

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis

Arturo B. Ramirez, Raksha Bhat, Debashish Sahay, Carmine De Angelis, Hariprasad Thangavel, Sina Hedayatpour, Lacey E. Dobrolecki, Agostina Nardone, Mario Giuliano, Chandandeep Nagi, Mothaffar Rimawi, C. Kent Osborne, Michael T. Lewis, Jackie L. Stilwell, Eric P. Kaldjian, Rachel Schiff, Meghana V. Trivedi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A hybrid technique of intracavitary and interstitial brachytherapy for locally advanced cervical cancer: initial outcomes of a single-institute experience

Naoya Murakami, Kazuma Kobayashi, Satoshi Shima, Keisuke Tsuchida, Tairo Kashihara, Nikolaos Tselis, Rei Umezawa, Kana Takahashi, Koji Inaba, Yoshinori Ito, Hiroshi Igaki, Yuko Nakayama, Koji Masui, Ken Yoshida, Tomoyasu Kato, Jun Itami

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression of long non-coding RNAs (lncRNAs) has been dysregulated in non-small cell lung cancer tissues

Farbod Esfandi, Mohammad Taheri, Mir Davood Omrani, Mohammad Behgam Shadmehr, Shahram Arsang-Jang, Roshanak Shams, Soudeh Ghafouri-Fard

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

β2-microglobulin has a different regulatory molecular mechanism between ER+ and ER− breast cancer with HER2−

Dandan Chai, Kesheng Li, Huifen Du, Suisheng Yang, Rong Yang, Yang Xu, Xiaowen Lian

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells

Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan, Jian-Guo Cao, Kai-qun Ren

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The ERH gene regulates migration and invasion in 5637 and T24 bladder cancer cells

Kun Pang, Zhiguo Zhang, Lin Hao, Zhenduo Shi, Bo Chen, Guanghui Zang, Yang Dong, Rui Li, Ying Liu, Jie Wang, Jianjun Zhang, Longjun Cai, Xiaoxiao Han, Conghui Han

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

18F-FDG PET/CT-based metabolic metrics in recurrent tumors of ovarian clear cell carcinoma and their prognostic implications

Shuang Ye, Shuai Liu, Libing Xiang, Xiaohua Wu, Huijuan Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Bioinformatic exploration of OLFML2B overexpression in gastric cancer base on multiple analyzing tools

Jiaxin Liu, Zhao Liu, Xiaozhi Zhang, Tuotuo Gong, Demao Yao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Utilization of a breast cancer risk assessment tool by internal medicine residents in a primary care clinic: impact of an educational program

Siddhartha Yadav, Sarah Hartkop, Paola Yumpo Cardenas, Rand Ladkany, Alexandra Halalau, Sandor Shoichet, Michael Maddens, Dana Zakalik

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

Tarun Karthik Kumar Mamidi, Jiande Wu, Chindo Hicks

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic models for breast cancer: a systematic review

Minh Tung Phung, Sandar Tin Tin, J. Mark Elwood

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A multicenter open-label phase II trial to evaluate nivolumab and ipilimumab for 2nd line therapy in elderly patients with advanced esophageal squamous cell cancer (RAMONA)

Nadja M. Meindl-Beinker, Johannes Betge, Tobias Gutting, Elke Burgermeister, Sebastian Belle, Tianzuo Zhan, Nadine Schulte, Martin Maenz, Matthias P. Ebert, Nicolai Haertel

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis

Rita T. Lawlor, Nicola Veronese, Antonio Pea, Alessia Nottegar, Lee Smith, Camilla Pilati, Jacopo Demurtas, Matteo Fassan, Liang Cheng, Claudio Luchini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145

Hongyang Sui, Anfeng Lou, Zhisong Li, Jianjun Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors

Hilde Ytre-Hauge Smeland, Ning Lu, Tine V. Karlsen, Gerd Salvesen, Rolf K. Reed, Linda Stuhr

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Malignant perivascular epithelioid cell tumor of the lung synchronous with a primary adenocarcinoma: one case report and review of the literature

Jikai Zhao, Haohua Teng, Ruiying Zhao, Wenjie Ding, Keke Yu, Lei Zhu, Jie Zhang, Yuchen Han

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid, Niamh E. Buckley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

TM4SF1 is a potential target for anti-invasion and metastasis in ovarian cancer

Caiyun Gao, Hongyu Yao, Huimin Liu, Yanying Feng, Zhijun Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nomogram based on homogeneous and heterogeneous associated factors for predicting bone metastases in patients with different histological types of lung cancer

Chao Zhang, Min Mao, Xu Guo, Ping Cui, Lianmin Zhang, Yao Xu, Lili Li, Xiuxin Han, Karl Peltzer, Shunbin Xiong, Vladimir P. Baklaushev, Xin Wang, Guowen Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer burden in the Caribbean: an overview of the Martinique Cancer Registry profile

Clarisse Joachim, Jacqueline Veronique-Baudin, Stephen Ulric-Gervaise, Audrey Pomier, Aimée Pierre-Louis, Mylène Vestris, Jean-Luc Novella, Moustapha Drame, Jonathan Macni, Patrick Escarmant

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Increased MET gene copy number negatively affects the survival of esophageal squamous cell carcinoma patients

Yanqiu Wang, Zhengzeng Jiang, Chen Xu, Hao Wang, Lijie Tan, Jieakesu Su, Xin Wang, Dongxian Jiang, Yingyong Hou, Qi Song

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic significance of the advanced lung cancer inflammation index in patients with unresectable metastatic colorectal cancer: a retrospective study

Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Kenjiro Kimura, Ryosuke Amano, Kosei Hirakawa, Masaichi Ohira

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Decitabine plus CLAG chemotherapy as a bridge to haploidentical transplantation in the setting of acute myeloid leukemia relapse after HLA-matched sibling transplantation: a case report

Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang, Guoqing Wei

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines

Stefanie Klenke, Neval Akdeli, Patrick Stelmach, Lukas Heukamp, Johannes H. Schulte, Hagen S. Bachmann

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Poor prognosis of retroperitoneal mixed extragonadal germ cell tumors in an HIV-infected man with severe immunosuppression and bilateral cryptorchidism: a case report

Ruili Li, Hongjun Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules

Masanori Teshima, Kazuya Tokita, Eijitsu Ryo, Fumihiko Matsumoto, Madoka Kondo, Yota Ikegami, Hirotaka Shinomiya, Naoki Otsuki, Nobuyoshi Hiraoka, Ken-ichi Nibu, Seiichi Yoshimoto, Taisuke Mori

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohort

Kazuki Sone, Tetsuya Oguri, Takehiro Uemura, Akira Takeuchi, Satoshi Fukuda, Osamu Takakuwa, Ken Maeno, Kensuke Fukumitsu, Yoshihiro Kanemitsu, Hirotsugu Ohkubo, Masaya Takemura, Yutaka Ito, Akio Niimi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression

Libo Sun, Xingyi Jin, Lijuan Xie, Guangjun Xu, Yunxia Cui, Zhuo Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells

Catherine H. Kaschula, Rosanna Tuveri, Ellen Ngarande, Kevin Dzobo, Christopher Barnett, Daniel A. Kusza, Lisa M. Graham, Arieh A. Katz, Mohamed Suhail Rafudeen, M. Iqbal Parker, Roger Hunter, Georgia Schäfer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Analytical validation of CanAssist-Breast: an immunohistochemistry based prognostic test for hormone receptor positive breast cancer patients

Arun Kumar Attuluri, Chandra Prakash V. Serkad, Aparna Gunda, Charusheila Ramkumar, Chetana Basavaraj, Ljubomir Buturovic, Lekshmi Madhav, Nirupama Naidu, Naveen Krishnamurthy, R. Prathima, Suchita Kanaldekar, Manjiri M. Bakre

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

Ming-Wei Lai, Yu-De Chu, Chih-Lang Lin, Rong-Nan Chien, Ta-Sen Yeh, Tai-Long Pan, Po-Yuan Ke, Kwang-Hui Lin, Chau-Ting Yeh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Single dose of dexamethasone is not associated with postoperative recurrence and mortality in breast cancer patients: a propensity-matched cohort study

Myoung Hwa Kim, Dong Wook Kim, Seho Park, Joo Heung Kim, Ki Young Lee, Jisung Hwang, Young Chul Yoo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Decreased serum carbohydrate antigen 19–9 levels after neoadjuvant therapy predict a better prognosis for patients with pancreatic adenocarcinoma: a multicenter case-control study of 240 patients

Shuichi Aoki, Fuyuhiko Motoi, Yoshiaki Murakami, Masayuki Sho, Sohei Satoi, Goro Honda, Kenichiro Uemura, Ken-ichi Okada, Ippei Matsumoto, Minako Nagai, Hiroaki Yanagimoto, Masanao Kurata, Takumi Fukumoto, Masamichi Mizuma, Hiroki Yamaue, Michiaki Unno, for the Multicenter Study Group of Pancreatobiliary Surgery (MSG-PBS)

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

Jesse Bakke, William C. Wright, Anthony E. Zamora, Peter Oladimeji, Jeremy Chase Crawford, Christopher T. Brewer, Robert J. Autry, William E. Evans, Paul G. Thomas, Taosheng Chen

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Second and third look laparoscopy in pT4 colon cancer patients for early detection of peritoneal metastases; the COLOPEC 2 randomized multicentre trial

Vivian P. Bastiaenen, Charlotte E. L. Klaver, Niels F. M. Kok, Johannes H. W. de Wilt, Ignace H. J. T. de Hingh, Arend G. J. Aalbers, Djamila Boerma, Andre J. A. Bremers, Jacobus W. A. Burger, Eino B. van Duyn, Pauline Evers, Wilhelmina M. U. van Grevenstein, Patrick H. J. Hemmer, Eva V. E. Madsen, Petur Snaebjornsson, Jurriaan B. Tuynman, Marinus J. Wiezer, Marcel G. W. Dijkgraaf, Jarmila D. W. van der Bilt, Pieter J. Tanis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy

Kazuaki Harada, Wataru Okamoto, Sachiyo Mimaki, Yasuyuki Kawamoto, Hideaki Bando, Riu Yamashita, Satoshi Yuki, Takayuki Yoshino, Yoshito Komatsu, Atsushi Ohtsu, Naoya Sakamoto, Katsuya Tsuchihara

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prevalence of BRCA mutations among hereditary breast and/or ovarian cancer patients in Arab countries: systematic review and meta-analysis

Khadiga Abdulrashid, Nour AlHussaini, Wifag Ahmed, Lukman Thalib

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

Wenxing Chen, Yanhong Pan, Siliang Wang, Yuping Liu, Guangying Chen, Liang Zhou, Chao Zhang, Wenting Ni, Aiyun Wang, Yin Lu, Shile Huang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC

Victoria J. Gennaro, Helen Wedegaertner, Steven B. McMahon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform

Andrew Riley, Victoria Green, Ramsah Cheah, Gordon McKenzie, Laszlo Karsai, James England, John Greenman

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Minichromosome Maintenance (MCM) family as potential diagnostic and prognostic tumor markers for human gliomas

Cong Hua, Gang Zhao, Yunqian Li, Li Bie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Molecular iodine exerts antineoplastic effects by diminishing proliferation and invasive potential and activating the immune response in mammary cancer xenografts

Irasema Mendieta, Rosa E. Nuñez-Anita, Mario Nava-Villalba, Xóchitl Zambrano-Estrada, Evangelina Delgado-González, Brenda Anguiano, Carmen Aceves

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability

Zhihua Shen, Xiaomin Liao, Zhongming Shao, Muyin Feng, Jianling Yuan, Sisi Wang, Siyuan Gan, Yanping Ha, Zhiwei He, Wei Jie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features

Jiaxian Yu, Yueming Hu, Yafei Xu, Jue Wang, Jiajie Kuang, Wei Zhang, Jianlin Shao, Dianjing Guo, Yejun Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Treatment preferences of patients with relapsed and refractory multiple myeloma: a qualitative study

Janet A. Parsons, Nicole R. Greenspan, Natalie A. Baker, Chris McKillop, Lisa K. Hicks, Olivia Chan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel human in vitro papillomavirus type 16 positive tonsil cancer cell line with high sensitivity to radiation and cisplatin

Ola Forslund, Natsuki Sugiyama, Chengjun Wu, Naveen Ravi, Yuesheng Jin, Sabine Swoboda, Fredrik Andersson, Davit Bzhalava, Emilie Hultin, Kajsa Paulsson, Joakim Dillner, Stefan Schwartz, Johan Wennerberg, Lars Ekblad

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf

Connor M. Blair, Nicola M. Walsh, Bruce H. Littman, Frank W. Marcoux, George S. Baillie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Malignant tumours in urban Ghana: evidence from the city of Kumasi

Yaw Ampem Amoako, Baffour Awuah, Rita Larsen-Reindorf, Fred Kwame Awittor, Gloria Kyem, Kwame Ofori-Boadu, Ernest Osei-Bonsu, Dennis Odai Laryea

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Axin gene methylation status correlates with radiosensitivity of lung cancer cells

Lian-He Yang, Yang Han, Guang Li, Hong-Tao Xu, Gui-Yang Jiang, Yuan Miao, Xiu-Peng Zhang, Huan-Yu Zhao, Zheng-Fan Xu, Maggie Stoecker, Endi Wang, Ke Xu, En-Hua Wang

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: The imbalance in the complement system and its possible physiological mechanisms in patients with lung cancer

Ping Zhao, Jun Wu, Feiteng Lu, Xuan Peng, Chenlin Liu, Nanjin Zhou, Muying Ying

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cardiovascular medication use and risks of colon cancer recurrences and additional cancer events: a cohort study

Erin J. A. Bowles, Onchee Yu, Rebecca Ziebell, Lu Chen, Denise M. Boudreau, Debra P. Ritzwoller, Rebecca A. Hubbard, Jennifer M. Boggs, Andrea N. Burnett-Hartman, Andrew Sterrett, Monica Fujii, Jessica Chubak

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu, Zhaoxin Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A preliminary trial examining a ‘real world’ approach for increasing physical activity among breast cancer survivors: findings from project MOVE

Cristina M. Caperchione, Catherine M. Sabiston, Sean Stolp, Joan L. Bottorff, Kristin L. Campbell, Neil D. Eves, Susan L. Ellard, Carolyn Gotay, Paul Sharp, Tanya Pullen, Kayla M. Fitzpatrick

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic and clinicopathological significance of PD-L1 expression in patients with diffuse large B-cell lymphoma: a meta-analysis

Liping Qiu, Hanlu Zheng, Xiaoying Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Assessment of change in quality of life, carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome

Daniel M. Halperin, Lynn Huynh, Jennifer L. Beaumont, Beilei Cai, Rachel H. Bhak, Sahil Narkhede, Todor Totev, Mei S. Duh, Maureen P. Neary, David Cella

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Comparing stereotactic ablative radiotherapy (SABR) versus re-trans-catheter arterial chemoembolization (re-TACE) for hepatocellular carcinoma patients who had incomplete response after initial TACE (TASABR): a randomized controlled trial

Liang-Cheng Chen, Wen-Yen Chiou, Hon-Yi Lin, Moon-Sing Lee, Yuan-Chen Lo, Li-Wen Huang, Chun-Ming Chang, Tsung-Hsing Hung, Chih-Wen Lin, Kuo-Chih Tseng, Dai-Wei Liu, Feng-Chun Hsu, Shih-Kai Hung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Efficacy of bevacizumab combined with erlotinib for advanced hepatocellular carcinoma: a single-arm meta-analysis based on prospective studies

Liyun He, Huan Deng, Jun Lei, Fengming Yi, Jine Li, Xiu De Fan, Yiping Wei, Jianjun Xu, Wenxiong Zhang

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

HPV insertional pattern as a personalized tumor marker for the optimized tumor diagnosis and follow-up of patients with HPV-associated carcinomas: a case report

Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, Didier Peiffert, Agnès Leroux, Xavier Sastre-Garau

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Case-control Indian buffet process identifies biomarkers of response to Codrituzumab

Melanie F. Pradier, Bernhard Reis, Lori Jukofsky, Francesca Milletti, Toshihiko Ohtomo, Fernando Perez-Cruz, Oscar Puig

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

First-in-class immune-modulating small molecule Icaritin in advanced hepatocellular carcinoma: preliminary results of safety, durable survival and immune biomarkers

Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng, Binghe Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

First-line cetuximab versus bevacizumab for RAS and BRAF wild-type metastatic colorectal cancer: a systematic review and meta-analysis

Bobo Zheng, Xin Wang, Mingtian Wei, Quan Wang, Jiang Li, Liang Bi, Xiangbing Deng, Ziqiang Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Establishing of mouse oral carcinoma cell lines derived from transgenic mice and their use as syngeneic tumorigenesis models

Yi-Fen Chen, Chung-Ji Liu, Li-Han Lin, Chung-Hsien Chou, Li-Yin Yeh, Shu-Chun Lin, Kuo-Wei Chang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparative efficacy of six therapies for Hypopharyngeal and laryngeal neoplasms: a network meta-analysis

Juan Che, Yanlin Wang, Xiaolin Zhang, Jun Chen

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Assessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial

Maria Di Bartolomeo, Monica Niger, Federica Morano, Salvatore Corallo, Maria Antista, Stefano Tamberi, Sara Lonardi, Samantha Di Donato, Rossana Berardi, Mario Scartozzi, Giovanni Gerardo Cardellino, Francesco Di Costanzo, Lorenza Rimassa, Alberto Gianluigi Luporini, Raffaella Longarini, Alberto Zaniboni, Alessandro Bertolini, Gianluca Tomasello, Graziella Pinotti, Giorgio Scagliotti, Giampaolo Tortora, Andrea Bonetti, Andrea Spallanzani, Giovanni Luca Frassineti, Davide Tassinari, Francesco Giuliani, Saverio Cinieri, Evaristo Maiello, Claudio Verusio, Sergio Bracarda, Vincenzo Catalano, Michele Basso, Libero Ciuffreda, Ferdinando De Vita, Hector Soto Parra, Lorenzo Fornaro, Marta Caporale, Filippo de Braud, Filippo Pietrantonio

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, Cornelis F. M. Sier, Wilma E. Mesker

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

A lung cancer patient with deep vein thrombosis:a case report and literature review

Yungu Chen, Yiu Sing Tsang, Xiaoxia Chou, Jiong Hu, Qing Xia

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Late presentation of hepatitis B among patients with newly diagnosed hepatocellular carcinoma: a national cohort study

Dong Hyun Sinn, Danbee Kang, Minwoong Kang, Seung Woon Paik, Eliseo Guallar, Juhee Cho, Geum-Youn Gwak

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Age-adjusted high-dose chemotherapy and autologous stem cell transplant in elderly and fit primary CNS lymphoma patients

Elisabeth Schorb, Juergen Finke, Gabriele Ihorst, Benjamin Kasenda, Heidi Fricker, Gerald Illerhaus

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pretreatment albumin/fibrinogen ratio as a promising predictor for the survival of advanced non small-cell lung cancer patients undergoing first-line platinum-based chemotherapy

Jun Ying, Danfei Zhou, Tongjie Gu, Jianda Huang, Haijian Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic value of PKM2 and its correlation with tumour cell PD-L1 in lung adenocarcinoma

Chang-Ying Guo, Qian Zhu, Fang-Fang Tou, Xiao-Ming Wen, Yu-Kang Kuang, Hao Hu

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A prospective, single-arm, open-label, non-randomized, phase IIa trial of a nonavalent prophylactic HPV vaccine to assess immunogenicity of a prime and deferred-booster dosing schedule among 9–11 year-old girls and boys – clinical protocol

Yi Zeng, Anna-Barbara Moscicki, Vikrant V. Sahasrabuddhe, Francisco Garcia, Heide Woo, Chiu-Hsieh Hsu, Eva Szabo, Eileen Dimond, Susan Vanzzini, Angelica Mondragon, Valerie Butler, Hillary DeRose, H.-H. Sherry Chow

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Systemic and tumor-directed therapy for oligometastatic prostate cancer: study protocol for a phase II trial for veterans with de novo oligometastatic disease

Neil R. Parikh, Claudia Huiza, Jill S. Patel, Sonny Tsai, Nathisha Kalpage, May Thein, Sage Pitcher, Steve P. Lee, Warren S. Inouye, Mark L. Jordan, Homayoon Sanati, Lida Jafari, Carol J. Bennett, Greg E. Gin, Amar U. Kishan, Robert E. Reiter, Michael Lewis, Ahmad Sadeghi, William J. Aronson, Isla P. Garraway, Matthew B. Rettig, Nicholas G. Nickols

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genome-wide copy number alteration and VEGFA amplification of circulating cell-free DNA as a biomarker in advanced hepatocellular carcinoma patients treated with Sorafenib

Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park, Baek-Yeol Ryoo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

LAPTM4B is a novel diagnostic and prognostic marker for lung adenocarcinoma and associated with mutant EGFR

Lu Wang, Yue Meng, Qing-Yun Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Thyroid Cancer in Ecuador, a 16 years population-based analysis (2001–2016)

Jorge Salazar-Vega, Esteban Ortiz-Prado, Paola Solis-Pazmino, Lenin Gómez-Barreno, Katherine Simbaña-Rivera, Aquiles R. Henriquez-Trujillo, Juan P. Brito, Theofilos Toulkeridis, Marco Coral-Almeida

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Multimodal multiphoton imaging for label-free monitoring of early gastric cancer

Lianhuang Li, Deyong Kang, Zicheng Huang, Zhenlin Zhan, Changyin Feng, Yongjian Zhou, Haohua Tu, Shuangmu Zhuo, Jianxin Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cytology material is equivalent to tumor tissue in determining mutations of BRCA 1/2 genes in patients with tubo-ovarian high grade serous carcinoma

Andreja Gornjec, Srdjan Novakovic, Vida Stegel, Marko Hocevar, Ziva Pohar Marinsek, Barbara Gazic, Mateja Krajc, Erik Skof

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

LncRNA ENST00000539653 acts as an oncogenic factor via MAPK signalling in papillary thyroid cancer

Bin Song, Rurun Li, Zhihua Zuo, Juan Tan, Ling Liu, Dafa Ding, Yibing Lu, Dawei Hou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Early assessment with 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography to predict short-term outcome in clear cell renal carcinoma treated with nivolumab

Tadashi Tabei, Noboru Nakaigawa, Tomohiro Kaneta, Ichiro Ikeda, Keiichi Kondo, Kazuhide Makiyama, Hisashi Hasumi, Narihiko Hayashi, Takashi Kawahara, Koji Izumi, Kimito Osaka, Kentaro Muraoka, Jun-ichi Teranishi, Yasuhide Miyoshi, Yasushi Yumura, Hiroji Uemura, Kazuki Kobayashi, Tomio Inoue, Masahiro Yao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells

Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje, Vladimir L. Sukhorukov

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells

Sophie Cowman, Yuen Ngan Fan, Barry Pizer, Violaine Sée

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression of C-terminal ALK, RET, or ROS1 in lung cancer cells with or without fusion

Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada, Yasushi Yoshimura

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Upregulation of SLC2A3 gene and prognosis in colorectal carcinoma: analysis of TCGA data

Eunyoung Kim, Sohee Jung, Won Seo Park, Joon-Hyop Lee, Rumi Shin, Seung Chul Heo, Eun Kyung Choe, Jae Hyun Lee, Kwangsoo Kim, Young Jun Chai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical analysis of patients with skeletal metastasis of lung cancer

Yong Jin Cho, Yung Min Cho, Sung Hyun Kim, Kyoo-Ho Shin, Sung-Taek Jung, Hyo Song Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CTCs as a prognostic and predictive biomarker for stage II/III Colon Cancer: a companion study to the PePiTA trial

Françoise Rothé, Marion Maetens, Ghizlane Rouas, Marianne Paesmans, Marc Van den Eynde, Jean-Luc Van Laethem, Philippe Vergauwe, Guido Deboever, Yacine Bareche, Caroline Vandeputte, Michail Ignatiadis, Alain Hendlisz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Long term efficacy and toxicity after stereotactic ablative reirradiation in locally relapsed stage III non-small cell lung cancer

Shakeel Sumodhee, Pierre-Yves Bondiau, Michel Poudenx, Charlotte Cohen, Arash O. Naghavi, Bernard Padovani, Daniel Maneval, Jocelyn Gal, Axel Leysalle, Hannah Ghalloussi, Josiane Otto, Jérôme Doyen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Locally advanced breast cancer treated with neoadjuvant chemotherapy and adjuvant radiotherapy: a retrospective cohort analysis

Jonathan Klein, William Tran, Elyse Watkins, Danny Vesprini, Frances C. Wright, Nicole J. Look Hong, Sonal Ghandi, Alex Kiss, Gregory J. Czarnota

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson, Margreet C. M. Vissers

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions

Rinako Miura, Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Miki Hashimura, Masataka Tochimoto, Sabine Kajita, Makoto Saegusa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differentiating atypical lipomatous tumors from lipomas with magnetic resonance imaging: a comparison with MDM2 gene amplification status

Carolin Knebel, Jan Neumann, Benedikt J. Schwaiger, Dimitris C. Karampinos, Daniela Pfeiffer, Katja Specht, Ulrich Lenze, Rüdiger von Eisenhart-Rothe, Ernst J. Rummeny, Klaus Woertler, Alexandra S. Gersing

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Spatial and temporal variations in Spain in the standardised ratio of in-hospital mortality due to colorectal cancer, 2008–2014

J. M. García-Torrecillas, M. C. Olvera-Porcel, M. Ferrer-Márquez, F. Rubio-Gil, M J. Sánchez, M. Rodríguez-Barranco

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Elucidating the transcriptional program of feline injection-site sarcoma using a cross-species mRNA-sequencing approach

Qi Wei, Stephen A. Ramsey, Maureen K. Larson, Noah E. Berlow, Donasian Ochola, Christopher Shiprack, Amita Kashyap, Bernard Séguin, Charles Keller, Christiane V. Löhr

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells

Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori, Martin Buess

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of candidate cancer predisposing variants by performing whole-exome sequencing on index patients from BRCA1 and BRCA2-negative breast cancer families

Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ben Caljon, Ingrid Pauwels, Maryse Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels, Jacques De Grève

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mean platelet volume/platelet count ratio in colorectal cancer: a retrospective clinical study

Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin, Fa-Quan Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

Juraimi Raihan, Umar Ahmad, Yoke Keong Yong, Zolkapli Eshak, Fauziah Othman, Aini Ideris

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

R-M Amini, G. Enblad, P. Hollander, S. Laszlo, E. Eriksson, K. Ayoola Gustafsson, A. Loskog, I. Thörn

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pap tests for cervical cancer screening test and contraception: analysis of data from the CONSTANCES cohort study

Stéphanie Mignot, Virginie Ringa, Solène Vigoureux, Marie Zins, Henri Panjo, Pierre-Jean Saulnier, Xavier Fritel

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Novel biomarkers distinguishing pancreatic head Cancer from distal cholangiocarcinoma based on proteomic analysis

Tsutomu Takenami, Shimpei Maeda, Hideaki Karasawa, Takashi Suzuki, Toru Furukawa, Takanori Morikawa, Tatsuyuki Takadate, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serum and cerebrospinal fluid Neudesin concentration and Neudesin Quotient as potential circulating biomarkers of a primary brain tumor

Olga M. Koper-Lenkiewicz, Joanna Kamińska, Anna Milewska, Karol Sawicki, Marek Jadeszko, Zenon Mariak, Joanna Reszeć, Violetta Dymicka-Piekarska, Joanna Matowicka-Karna

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Successful resection of pancreatic metastasis from oesophageal squamous cell carcinoma: a case report and review of the literature

Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida, Yuko Kitagawa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Attention to the principles of exercise training in exercise studies on prostate cancer survivors: a systematic review

Sarah E. Neil-Sztramko, Mary E. Medysky, Kristin L. Campbell, Kelcey A. Bland, Kerri M. Winters-Stone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of ADGRE5 as discriminating MYC target between Burkitt lymphoma and diffuse large B-cell lymphoma

Karsten Kleo, Lora Dimitrova, Elisabeth Oker, Nancy Tomaszewski, Erika Berg, Franziska Taruttis, Julia C. Engelmann, Philipp Schwarzfischer, Jörg Reinders, Rainer Spang, Wolfram Gronwald, Peter J. Oefner, Michael Hummel

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effectiveness of 18F-FDG PET/CT in the diagnosis and staging of osteosarcoma: a meta-analysis of 26 studies

Fanxiao Liu, Qingyu Zhang, Dongsheng Zhou, Jinlei Dong

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Intussusception reveals MUTYH-associated polyposis syndrome and colorectal cancer: a case report

Gustavo Heluani Antunes de Mesquita, Bárbara Justo Carvalho, Kayo Augusto de Almeida Medeiros, Fernanda Nii, Diego Ramos Martines, Leonardo Zumerkorn Pipek, Yuri Justi Jardim, Daniel Reis Waisberg, Marcos Takeo Obara, Roberta Sitnik, Alberto Meyer, Cristóvão Luis Pitangueiras Mangueira

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Peptide receptor radionuclide therapy in patients with medullary thyroid carcinoma: predictors and pitfalls

Carolien M. Beukhof, Tessa Brabander, Francien H. van Nederveen, Marie-Louise F. van Velthuysen, Yolanda B. de Rijke, Leo J. Hofland, Gaston J. H. Franssen, Lideke A. C. Fröberg, Boen L. R. Kam, W. Edward Visser, Wouter W. de Herder, Robin P. Peeters

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Changes of N6-methyladenosine modulators promote breast cancer progression

Lianpin Wu, Dengying Wu, Jinfeng Ning, Wei Liu, Donghong Zhang

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Adjuvant hepatic arterial infusion pump chemotherapy and resection versus resection alone in patients with low-risk resectable colorectal liver metastases – the multicenter randomized controlled PUMP trial

F. E. Buisman, M. Y. V. Homs, D. J. Grünhagen, W. F. Filipe, R. J. Bennink, M. G. H. Besselink, I. H. M. Borel Rinkes, R. C. G. Bruijnen, A. Cercek, M. I. D’Angelica, O. M. van Delden, M. L. Donswijk, L. van Doorn, P. G. Doornebosch, J. Emmering, J. I. Erdmann, N. S. IJzerman, C. Grootscholten, J. Hagendoorn, N. E. Kemeny, T. P. Kingham, E. G. Klompenhouwer, N. F. M. Kok, S. Koolen, K. F. D. Kuhlmann, M. C. Kuiper, M. G. E. Lam, R. H. J. Mathijssen, A. Moelker, E. Oomen-de Hoop, C. J. A. Punt, W. W. te Riele, J. M. L. Roodhart, R. J. Swijnenburg, W. Prevoo, P. J. Tanis, M. Vermaas, M. W. J. Versleijen, F. P. Veuger, M. J. Weterman, C. Verhoef, B. Groot Koerkamp

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intratumor heterogeneity index of breast carcinomas based on DNA methylation profiles

Emanuel M. Campoy, María T. Branham, Luis S. Mayorga, María Roqué

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic significance of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in giant cell tumor of the extremities

Zhenhao Chen, Guanglei Zhao, Feiyan Chen, Jun Xia, Li Jiang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Health literacy and patient participation in multidisciplinary tumor conferences in breast cancer care: a multilevel modeling approach

Christian Heuser, Annika Diekmann, Christoph Kowalski, Anna Enders, Rupert Conrad, Holger Pfaff, Lena Ansmann, Nicole Ernstmann

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Androgen receptor mRNA expression is a predictor for recurrence-free survival in non-muscle invasive bladder cancer

Masato Yasui, Takashi Kawahara, Koji Izumi, Masahiro Yao, Yukari Ishiguro, Hitoshi Ishiguro, Hiroji Uemura, Yasuhide Miyoshi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Diagnostic accuracy of 13N-ammonia PET, 11C-methionine PET and 18F-fluorodeoxyglucose PET: a comparative study in patients with suspected cerebral glioma

Qiao He, Linqi Zhang, Bing Zhang, Xinchong Shi, Chang Yi, Xiangsong Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A specific gene expression signature for visceral organ metastasis in breast cancer

C. D. Savci-Heijink, H. Halfwerk, J. Koster, H. M. Horlings, M. J. van de Vijver

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Non-functional pancreatic neuroendocrine tumours: emerging trends in incidence and mortality

Junjun Wu, Chi Sun, Enliang Li, Jiakun Wang, Xianping He, Rongfa Yuan, Chenghao Yi, Wenjun Liao, Linquan Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk factors affecting prognosis in metachronous liver metastases from WHO classification G1 and G2 gastroenteropancreatic neuroendocrine tumors after initial R0 surgical resection

Yang Lv, Xu Han, Xue-Feng Xu, Yuan Ji, Yu-Hong Zhou, Hui-Chuan Sun, Jian Zhou, Jia Fan, Wen-Hui Lou, Cheng Huang

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Abscopal effect of radiation on multiple lung metastases of lung adenocarcinoma: a case report

Aoi Kuroda, Takaya Tabuchi, Eri Iwami, Kotaro Sasahara, Tatsu Matsuzaki, Takahiro Nakajima, Yuki Tsutsumi, Keisuke Eguchi, Takeshi Terashima

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Predominant global glomerulosclerosis in patients of upper urinary tract urothelial carcinoma with pre-existing renal function impairment is a predictor of poor renal outcomes

Sheng-Wen Niu, Peir-In Liang, Ming-Yen Lin, Shih-Meng Yeh, Yen-Yi Zhen, Yu-Han Chang, Pin-Chia Huang, Chi-Chi Hung, I-Ching Kuo, Hugo You-Hsien Lin, Mei-Chuan Kuo, Wei-Ming Li, Chun-Nung Huang, Wen-Jeng Wu, Li-Tzong Chen, Yi-Wen Chiu, Shang-Jyh Hwang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of lymphocyte-monocyte ratio at diagnosis in Hodgkin lymphoma: a meta-analysis

Shing Fung Lee, Ting Ying Ng, Devon Spika

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: study protocol for a multicenter randomized phase II trial (the OCUU-CRPC study)

Taro Iguchi, Satoshi Tamada, Minoru Kato, Sayaka Yasuda, Takeshi Yamasaki, Tatsuya Nakatani

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Rationale and design of extended cancer education for longer term survivors (EXCELS): a randomized control trial of ‘high touch’ vs. ‘high tech’ cancer survivorship self-management tools in primary care

Stacy N. Davis, Denalee M. O’Malley, Alicja Bator, Pamela Ohman-Strickland, Lynn Clemow, Jeanne M. Ferrante, Benjamin F. Crabtree, Suzanne M. Miller, Patricia Findley, Shawna V. Hudson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708)

Young Shin Chung, Sang-Yoon Park, Jung-Yun Lee, Jeong-Yeol Park, Jeong-Won Lee, Hee Seung Kim, Dong Soo Suh, Yun Hwan Kim, Jong-Min Lee, Miseon Kim, Min Chul Choi, Seung-Hyuk Shim, Keun Ho Lee, Taejong Song, Jin Hwa Hong, Won Moo Lee, Banghyun Lee, In Ho Lee

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

How do breast cancer surgery scars impact survivorship? Findings from a nationwide survey in the United States

Jennifer Gass, Sunny Mitchell, Michael Hanna

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Functional role of SGK3 in PI3K/Pten driven liver tumor development

Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi, Xin Chen

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A web-based psycho-educational intervention (Fex-Can) targeting sexual dysfunction and fertility-related distress in young adults with cancer: study protocol of a randomized controlled trial

C. Lampic, L. Ljungman, C. Micaux Obol, L. E. Eriksson, L. Wettergren

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical application of ultrasound-guided percutaneous microwave ablation for benign breast lesions: a prospective study

Wei Zhang, Zhan-Qiang Jin, Masoud Baikpour, Jian-Min Li, Hui Zhang, Ting Liang, Xiao-Ming Pan, Wen He

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Reduced FRG1 expression promotes prostate cancer progression and affects prostate cancer cell migration and invasion

Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal, Manjusha Dixit

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

An unusual complication of sacral nerve root injury following bone marrow harvesting: a case report

Tae-Woo Nam, Hyun-Min Oh, Jae-Eun Lee, Ju-Hyun Kim, Jong-moon Hwang, Eunhee Park, Tae-Du Jung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Is exposure to tobacco associated with extrahepatic cholangiocarcinoma epidemics? A retrospective proportional mortality study in China

Lei Hou, Jingmei Jiang, Boqi Liu, Wei Han, Yanping Wu, Xiaonong Zou, Fang Xue, Yuanli Chen, Biao Zhang, Haiyu Pang, Yuyan Wang, Zixing Wang, Yaoda Hu, Junyao Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions

Bread Cruz, André Oliveira, Gislaine Ventrucci, Maria Cristina Cintra Gomes-Marcondes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Salivary gland carcinoma in Shanghai (2003–2012): an epidemiological study of incidence, site and pathology

Jin-Ye Fu, Chun-Xiao Wu, Shu-Kun Shen, Ying Zheng, Chen-Ping Zhang, Zhi-Yuan Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke, Tracy Robson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas

Ge Gao, Jintu Wang, Jan L. Kasperbauer, Nicole M. Tombers, Fei Teng, Honglan Gou, Yonggang Zhao, Zhenhong Bao, David I. Smith

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Relative efficacy of interventions in the treatment of second-line non-small cell lung cancer: a systematic review and network meta-analysis

Adrian D. Vickers, Katherine B. Winfree, Gebra Cuyun Carter, Urpo Kiiskinen, Min-Hua Jen, Donald Stull, James A. Kaye, David P. Carbone

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Depletion of PCAT-1 in head and neck cancer cells inhibits tumor growth and induces apoptosis by modulating c-Myc-AKT1-p38 MAPK signalling pathways

Subhayan Sur, Hiroshi Nakanishi, Robert Steele, Ratna B. Ray

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Bilateral mantle cell lymphoma of the ciliary body that responded to a combined local radiotherapy and chemotherapy regimen: a case report

Minghang Pei, Chan Zhao, Fei Gao, Meifen Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells

Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio, Alejandro Zentella-Dehesa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients

Krithika Bhuvaneshwar, Michael Harris, Yuriy Gusev, Subha Madhavan, Ramaswamy Iyer, Thierry Vilboux, John Deeken, Elizabeth Yang, Sadhna Shankar

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Micafungin prophylaxis for acute leukemia patients undergoing induction chemotherapy

Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park, Youngil Koh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation

Duan Chu, Lai Wei

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differential expressions of PD-1, PD-L1 and PD-L2 between primary and metastatic sites in renal cell carcinoma

Xingming Zhang, Xiaoxue Yin, Haoran Zhang, Guangxi Sun, Yaojing Yang, Junru Chen, Xudong Zhu, Peng Zhao, Jinge Zhao, Jiandong Liu, Ni Chen, Jia Wang, Pengfei Shen, Hao Zeng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Health-related quality of life as an endpoint in oncology phase I trials: a systematic review

Frédéric Fiteni, Isabelle Le Ray, Ahmad Ousmen, Nicolas Isambert, Amélie Anota, Franck Bonnetain

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Brain metastases in patients with neuroendocrine neoplasms: risk factors and outcome

Sebastian Krug, Freya Teupe, Patrick Michl, Thomas M. Gress, Anja Rinke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Feasibility of dynamic risk assessment for patients with repeated trans-arterial chemoembolization for hepatocellular carcinoma

Yehyun Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jong Eun Yeon, Kwan Soo Byun, Hye Soo Kim, Ji Hoon Kim, Seung Up Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Imaging biomarkers for well and moderate hepatocellular carcinoma: preoperative magnetic resonance image and histopathological correlation

Kun Huang, Zhi Dong, Huasong Cai, Mengqi Huang, Zhenpeng Peng, Ling Xu, Yingmei Jia, Chenyu Song, Zi-Ping Li, Shi-Ting Feng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow

Giselle Villa Flor Brunoro, Paulo Costa Carvalho, Valmir C. Barbosa, Dante Pagnoncelli, Claudia Vitória De Moura Gallo, Jonas Perales, René Peiman Zahedi, Richard Hemmi Valente, Ana Gisele da Costa Neves-Ferreira

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study

Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf, Axel Hauschild, for the ERIVANCE BCC Investigators

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Factors associated with low adherence to cervical cancer follow-up retest among HPV+/ cytology negative women: a study in programmatic context in a low-income population in Argentina

Juan Gago, Melisa Paolino, Silvina Arrossi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Follow-up care after treatment for prostate cancer: evaluation of a supported self-management and remote surveillance programme

Jane Frankland, Hazel Brodie, Deborah Cooke, Claire Foster, Rebecca Foster, Heather Gage, Jake Jordan, Ines Mesa-Eguiagaray, Ruth Pickering, Alison Richardson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intratumoral heterogeneity of EGFR-activating mutations in advanced NSCLC patients at the single-cell level

Longhua Guo, Zhihong Chen, Chongrui Xu, Xuchao Zhang, Honghong Yan, Jian Su, Jinji Yang, Zhi Xie, Weibang Guo, Feng Li, Yilong Wu, Qing Zhou

01.12.2019 | Technical Advance | Ausgabe 1/2019 Open Access

Protein interaction disruption in cancer

Matthew Ruffalo, Ziv Bar-Joseph

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Acute aerobic exercise effects on cognitive function in breast cancer survivors: a randomized crossover trial

Elizabeth A. Salerno, Kendrith Rowland, Arthur F. Kramer, Edward McAuley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue Chao, Kai Chen, Jiayi Zeng, Zhuofei Bi, Mingyan Guo, Yi Chen, Yandan Yao, Wei Wu, Shi Liang, Yan Nie

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma

Dorival Mendes Rodrigues-Junior, Soon Sim Tan, Luciano de Souza Viana, Andre Lopes Carvalho, Sai Kiang Lim, N Gopalakrishna Iyer, Andre Luiz Vettore

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Prostate cancer solitary metastasis to anal canal: case report and review of literature

Audrius Dulskas, Vaidas Cereska, Edvardas Zurauskas, Eugenijus Stratilatovas, Feliksas Jankevicius

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

HPV DNA integration site as proof of the origin of ovarian metastasis from endocervical adenocarcinoma: three case reports

Alexandra Arfi, Delphine Hequet, Guillaume Bataillon, Carine Tran-Perennou, Fereshteh Farkhondeh, Xavier Sastre-Garau, Virginie Fourchotte, Roman Rouzier, Enora Laas, Nicolas Pouget, Anne Vincent-Salomon, Emmanuelle Jeannot

01.12.2019 | Technical advance | Ausgabe 1/2019 Open Access

Advanced assessment of migration and invasion of cancer cells in response to mifepristone therapy using double fluorescence cytochemical labeling

Sabrina J. Ritch, BreeAnn N. Brandhagen, Alicia A. Goyeneche, Carlos M. Telleria

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Smoking status and subsequent gastric cancer risk in men compared with women: a meta-analysis of prospective observational studies

Wen-Ya Li, Yunan Han, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Regression of solid breast tumours in mice by Newcastle disease virus is associated with production of apoptosis related-cytokines

Juraimi Raihan, Umar Ahmad, Yoke Keong Yong, Zolkapli Eshak, Fauziah Othman, Aini Ideris

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Case report: reinitiating pembrolizumab treatment after small bowel perforation

Tim N. Beck, Alexander E. Kudinov, Essel Dulaimi, Yanis Boumber

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinicopathological characteristics and health care for Tibetan women with breast cancer: a cross-sectional survey

Yulan Zhao, Hanhuan Luo, Xintian Zhang, Tashi Bianba, Lin Li, Qian Wang, Lei Guo, Dian Wang, Yongge Ze, Shan Zheng

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao, Yi Wang

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Impact of AferBio® on quality of life and chemotherapy toxicity in advanced lung cancer patients (AFERBIO study): protocol study for a phase II randomized controlled trial

Daniel D’Almeida Preto, Mariana Toledo Baston, Camilla Centurion Geraige, Sarah Bertazzi Augusto, Marco Antonio de Oliveira, Augusto Elias Mamere, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Pedro Rafael Martins De Marchi, Bianca Sakamoto Ribeiro Paiva, Carlos Eduardo Paiva

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Physician requests by patients with malignant pleural mesothelioma in Japan

Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto, Nobukazu Fujimoto

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The determinants and impact of diagnostic delay in lymphoma in a TB and HIV endemic setting

Katherine Antel, Carly Levetan, Zainab Mohamed, Vernon J Louw, Jenna Oosthuizen, Gary Maartens, Estelle Verburgh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Does external beam radiation boost to pelvic lymph nodes improve outcomes in patients with locally advanced cervical cancer?

Caryn Wujanto, Bok Ai Choo, David Tan, Arunachalam Ilancheran, Joseph Ng, Jeffrey J. H. Low, Liang Shen, Johann Tang, Vicky Koh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Changes in functional brain networks and neurocognitive function in Chinese gynecological cancer patients after chemotherapy: a prospective longitudinal study

Yingchun Zeng, Andy S. K. Cheng, Ting Song, Xiujie Sheng, Huaidong Cheng, Yingwei Qiu, Jianfei Xie, Chetwyn C. H. Chan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer

Lingeng Lu, Huatian Huang, Jing Zhou, Wenxue Ma, Sean Mackay, Zuoheng Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Efficacy of an RNA-based multigene assay with core needle biopsy samples for risk evaluation in hormone-positive early breast cancer

Jeeyeon Lee, Eun Hye Lee, Ho Yong Park, Wan Wook Kim, Ryu Kyung Lee, Yee Soo Chae, Soo Jung Lee, Jee-Eun Kim, Byeong-il Kang, Jee Young Park, Ji-Young Park, Jin Hyang Jung

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The prognostic impact of tet oncogene family member 2 mutations in patients with acute myeloid leukemia: a systematic-review and meta-analysis

Ruiqi Wang, Xiaoning Gao, Li Yu

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6)

Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul, Hans J. van der Vliet, Marinus J. Wiezer, Djamila Boerma, Emma C. E. Wassenaar, Maartje Los, Cornelis B. Hunting, Arend G. J. Aalbers, Niels F. M. Kok, Koert F. D. Kuhlmann, Henk Boot, Myriam Chalabi, Schelto Kruijff, Lukas B. Been, Robert J. van Ginkel, Derk Jan A. de Groot, Rudolf S. N. Fehrmann, Johannes H. W. de Wilt, Andreas J. A. Bremers, Philip R. de Reuver, Sandra A. Radema, Karin H. Herbschleb, Wilhelmina M. U. van Grevenstein, Arjen J. Witkamp, Miriam Koopman, Nadia Haj Mohammad, Eino B. van Duyn, Walter J. B. Mastboom, Leonie J. M. Mekenkamp, Joost Nederend, Max J. Lahaye, Petur Snaebjornsson, Cornelis Verhoef, Hanneke W. M. van Laarhoven, Aeilko H. Zwinderman, Jeanette M. Bouma, Onno Kranenburg, Iris van ‘t Erve, Remond J. A. Fijneman, Marcel G. W. Dijkgraaf, Patrick H. J. Hemmer, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. J. T. de Hingh, Dutch Peritoneal Oncology Group (DPOG), Dutch Colorectal Cancer Group (DCCG)

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer

Jin-Yun Li, Wen-Xiao Huang, Xiao Zhou, Jie Chen, Zan Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparative survival benefit of currently licensed second or third line treatments for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) negative advanced or metastatic non-small cell lung cancer: a systematic review and secondary analysis of trials

Martin Connock, Xavier Armoiry, Alexander Tsertsvadze, G. J. Melendez-Torres, Pamela Royle, Lazaros Andronis, Aileen Clarke

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Breast cancer care in northern Ethiopia – cross-sectional analysis

Biniyam Tefera Deressa, Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis, Daniel Rauch

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Irreversible electroporation versus radiotherapy after induction chemotherapy on survival in patients with locally advanced pancreatic cancer: a propensity score analysis

Chaobin He, Jun Wang, Shuxin Sun, Yu Zhang, Xiaojun Lin, Xiangming Lao, Bokang Cui, Shengping Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Paracrine effects of CCN3 from non-cancerous hepatic cells increase signaling and progression of hepatocellular carcinoma

Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv, Qingan Jia

01.12.2019 | Technical advance | Ausgabe 1/2019 Open Access

Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples

Falk Zakrzewski, Laura Gieldon, Andreas Rump, Michael Seifert, Konrad Grützmann, Alexander Krüger, Sina Loos, Silke Zeugner, Karl Hackmann, Joseph Porrmann, Johannes Wagner, Karin Kast, Pauline Wimberger, Gustavo Baretton, Evelin Schröck, Daniela Aust, Barbara Klink

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A multicenter phase III study comparing Simultaneous Integrated Boost (SIB) radiotherapy concurrent and consolidated with S-1 versus SIB alone in elderly patients with esophageal and esophagogastric cancer – the 3JECROG P-01 study protocol

Chen Li, Xiaomin Wang, Xin Wang, Chun Han, Ping Wang, Qingsong Pang, Junqiang Chen, Xinchen Sun, Lan Wang, Wencheng Zhang, Yu Lin, Xiaolin Ge, Zongmei Zhou, Wenjie Ni, Xiao Chang, Jun Liang, Lei Deng, Wenqing Wang, Yidian Zhao, Zefen Xiao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Plasma levels of M-CSF and VEGF in laboratory diagnostics and differentiation of selected histological types of cervical cancers

Iwona Sidorkiewicz, Monika Zbucka-Krętowska, Kamil Zaręba, Emilia Lubowicka, Monika Zajkowska, Maciej Szmitkowski, Ewa Gacuta, Sławomir Ławicki

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The presence of bacteria varies between colorectal adenocarcinomas, precursor lesions and non-malignant tissue

Caspar Bundgaard-Nielsen, Ulrik T. Baandrup, Lars P. Nielsen, Suzette Sørensen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway

Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen, Hongyu Yang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CD44, TGM2 and EpCAM as novel plasma markers in endometrial cancer diagnosis

Anna Torres, Małgorzata Pac-Sosińska, Krzysztof Wiktor, Tomasz Paszkowski, Ryszard Maciejewski, Kamil Torres

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel spheroid-based co-culture model mimics loss of keratinocyte differentiation, melanoma cell invasion, and drug-induced selection of ABCB5-expressing cells

Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf, Mathias Hafner

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

How many samples are needed to infer truly clonal mutations from heterogenous tumours?

Luka Opasic, Da Zhou, Benjamin Werner, David Dingli, Arne Traulsen

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Local excision in mid-to-low rectal cancer patients who revealed clinically total or near-total regression after preoperative chemoradiotherapy; a proposed trial

Jong Lyul Lee, Seok-Byung Lim, Chang Sik Yu, In Ja Park, Yong Sik Yoon, Chan Wook Kim, Seong Ho Park, Jong Seok Lee, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jong Hoon Kim, Jin-hong Park, Jihun Kim, Minkyu Han

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

miR-140-5p could suppress tumor proliferation and progression by targeting TGFBRI/SMAD2/3 and IGF-1R/AKT signaling pathways in Wilms’ tumor

Zhuo Liu, Feng He, Shengrong OuYang, Yuanyuan Li, Feifei Ma, Huibo Chang, Dingding Cao, Jianxin Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Ascites from ovarian cancer patients stimulates MUC16 mucin expression and secretion in human peritoneal mesothelial cells through an Akt-dependent pathway

Isabelle Matte, Perrine Garde-Granger, Paul Bessette, Alain Piché

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Ιmpact of sunitinib-induced hypothyroidism on survival of patients with metastatic renal cancer

Theofanis Vasileiadis, Michail Chrisofos, Michail Safioleas, Konstantinos Kontzoglou, Konstantinos Papazisis, Athina Sdrolia

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy

Hang Sun, Hongxin Ding, Jianjun Wang, Emma Zhang, Yihua Fang, Zhenhua Li, Xiao Yu, Chongren Wang, Yifan Zhao, Kan Chen, Siwan Wen, Liang Li, Shan Shan, Liu Hong, Face Chen, Pu Su

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumor Hypervascularity and hand-foot-skin reaction predict better outcomes in combination treatment of TACE and Sorafenib for intermediate hepatocellular carcinoma

Enxin Wang, Dongdong Xia, Wei Bai, Jie Yuan, Xiaomei Li, Jing Niu, Zhanxin Yin, Jielai Xia, Hongwei Cai, Daiming Fan, Guohong Han, Lei Liu

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

The increase in activating EGFR mutation in plasma is an early biomarker to monitor response to osimertinib: a case report

Marzia Del Re, Eleonora Rofi, Carla Cappelli, Gianfranco Puppo, Stefania Crucitta, Simona Valeggi, Antonio Chella, Romano Danesi, Iacopo Petrini

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis

Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman, Félix Fernández-Madrid

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cytogenetic characterization of the malignant primitive neuroectodermal SK-PN-DW tumor cell line

Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu, Feng Wang

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Neoadjuvant anti-programmed Death-1 immunotherapy by Pembrolizumab in resectable nodal positive stage II/IIIa non-small-cell lung cancer (NSCLC): the NEOMUN trial

Florian Eichhorn, Laura V. Klotz, Helge Bischoff, Michael Thomas, Felix Lasitschka, Hauke Winter, Hans Hoffmann, Martin E. Eichhorn

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

It’s never too late - balance and endurance training improves functional performance, quality of life, and alleviates neuropathic symptoms in cancer survivors suffering from chemotherapy-induced peripheral neuropathy: results of a randomized controlled trial

S. Kneis, A. Wehrle, J. Müller, C. Maurer, G. Ihorst, A. Gollhofer, H. Bertz

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Concomitant use of pembrolizumab and entinostat in adult patients with metastatic uveal melanoma (PEMDAC study): protocol for a multicenter phase II open label study

Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M. Nilsson, Jonas A. Nilsson, Lars Ny

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Body weight loss after surgery affects the continuity of adjuvant chemotherapy for pancreatic cancer

Yoshifumi Morita, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yasushi Shibasaki, Hirotoshi Kikuchi, Hiroyuki Konno, Hiroya Takeuchi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Role of intraparotid node metastasis in mucoepidermoid carcinoma of the parotid gland

Xingyu Niu, Qigen Fang, Fei Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The association between post-treatment surveillance testing and survival in stage II and III colon cancer patients: An observational comparative effectiveness study

Robert B. Hines, Md Jibanul Haque Jiban, Adrian V. Specogna, Priya Vishnubhotla, Eunkyung Lee, Shunpu Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

microRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer

Sunyoung Park, Jungho Kim, Kiyoon Eom, Sehee Oh, Sunghyun Kim, Geehyuk Kim, Sungwoo Ahn, Kwang Hwa Park, Dawn Chung, Hyeyoung Lee

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy versus palliative systemic chemotherapy in stomach cancer patients with peritoneal dissemination, the study protocol of a multicentre randomised controlled trial (PERISCOPE II)

W. J. Koemans, R. T. van der Kaaij, H. Boot, T. Buffart, A. A. F. A. Veenhof, K. J. Hartemink, C. Grootscholten, P. Snaebjornsson, V. P. Retel, H. van Tinteren, S. Vanhoutvin, V. van der Noort, A. Houwink, C. Hahn, A. D. R. Huitema, M. Lahaye, M. Los, P. van den Barselaar, O. Imhof, A. Aalbers, G. M. van Dam, B. van Etten, B. P. L. Wijnhoven, M. D. P. Luyer, D. Boerma, J. W. van Sandick

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association of pathway mutation with survival after recurrence in colorectal cancer patients treated with adjuvant fluoropyrimidine and oxaliplatin chemotherapy

Dae-Won Lee, Sae-Won Han, Yongjun Cha, Jeong Mo Bae, Hwang-Phill Kim, Jaemyun Lyu, Hyojun Han, Hyoki Kim, Hoon Jang, Duhee Bang, Jae-Kyung Won, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang, Tae-You Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes

Alexandre A. B. A. da Costa, Luisa M. do Canto, Simon Jonas Larsen, Adriana Regina Gonçalves Ribeiro, Carlos Eduardo Stecca, Annabeth Høgh Petersen, Mads M. Aagaard, Louise de Brot, Jan Baumbach, Glauco Baiocchi, Maria Isabel Achatz, Silvia Regina Rogatto

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer

Constantin Georgescu, Joshua M. Corbin, Sandra Thibivilliers, Zachary D. Webb, Yan D. Zhao, Jan Koster, Kar-Ming Fung, Adam S. Asch, Jonathan D. Wren, Maria J. Ruiz-Echevarría

01.12.2019 | Technical advance | Ausgabe 1/2019 Open Access

Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)

Leen Van de Sande, Wouter Willaert, Sarah Cosyns, Kaat De Clercq, Molood Shariati, Katrien Remaut, Wim Ceelen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Health-related quality of life and utility in head and neck cancer survivors

Li-Jen Liao, Wan-Lun Hsu, Wu-Chia Lo, Po-Wen Cheng, Pei-Wei Shueng, Chen-Hsi Hsieh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The healthcare costs of treating human papillomavirus-related cancers in Norway

Hannah Hylin, Helene Thrane, Kine Pedersen, Ivar S. Kristiansen, Emily A. Burger

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Blood serum proteins as biomarkers for prediction of survival, locoregional control and distant metastasis rate in radiotherapy and radio-chemotherapy for non-small cell lung cancer

Rafał Suwinski, Monika Giglok, Katarzyna Galwas-Kliber, Adam Idasiak, Bozena Jochymek, Regina Deja, Barbara Maslyk, Jolanta Mrochem-Kwarciak, Dorota Butkiewicz

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Differences in colonic crypt morphology of spontaneous and colitis-associated murine models via second harmonic generation imaging to quantify colon cancer development

Sandra P. Prieto, Cassandra L. Reed, Haley M. James, Kyle P. Quinn, Timothy J. Muldoon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

A. Hendricks, F. Gieseler, S. Nazzal, J. H. Bräsen, R. Lucius, B. Sipos, J. H. Claasen, Th. Becker, S. Hinz, G. Burmeister, C. Schafmayer, C. Schrader

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Combined kyphoplasty and intraoperative radiotherapy (Kypho-IORT) versus external beam radiotherapy (EBRT) for painful vertebral metastases - a randomized phase III study

Frederic Bludau, Grit Welzel, Tina Reis, Yasser Abo-Madyan, Elena Sperk, Frank Schneider, Sven Clausen, Arne M. Ruder, Udo Obertacke, Maged M. Ghaly, Frederik Wenz, Frank A. Giordano

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic impact of tumor location in colon cancer: the Monitoring of Cancer Incidence in Japan (MCIJ) project

Hiroko Nakagawa-Senda, Megumi Hori, Tomohiro Matsuda, Hidemi Ito

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Downstaging in opportunistic breast cancer screening in Brazil: a temporal trend analysis

Diama Bhadra Vale, Cassio Cardoso Filho, Julia Yoriko Shinzato, Fernanda Servidoni Spreafico, Partha Basu, Luiz Carlos Zeferino

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

AVAiLABLE NIS – AVASTIN® in lung cancer treatment in routine oncology practice in Germany

Mark-Oliver Zahn, Dominik Linck, Christoph Losem, Christian Gessner, Holger Metze, Vincent E. Gaillard, Hans Werner Tessen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tissue-specific impact of stem-loops and quadruplexes on cancer breakpoints formation

Kseniia Cheloshkina, Maria Poptsova

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Dissecting TSC2-mutated renal and hepatic angiomyolipomas in an individual with ARID1B-associated intellectual disability

Bernt Popp, Abbas Agaimy, Cornelia Kraus, Karl X. Knaup, Arif B. Ekici, Steffen Uebe, André Reis, Michael Wiesener, Christiane Zweier

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer

Peter McAnena, Kahraman Tanriverdi, Catherine Curran, K. Gilligan, Jane E. Freedman, James A. L. Brown, Michael J. Kerin

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer

Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas, Yildiz E. Yilmaz

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Exploring the efficacy of an electronic symptom assessment and self-care intervention to preserve physical function in individuals receiving neurotoxic chemotherapy

Robert Knoerl, Edie Weller, Barbara Halpenny, Donna Berry

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells

Ming Zhong, Cheng Zhong, Wen Cui, Guanghui Wang, Gongpu Zheng, Li Li, Jing Zhang, Rujing Ren, Huijei Gao, Tingting Wang, Xin Li, Jiantu Che, Eiichi Gohda

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles

S. Visser, J. Hou, K. Bezemer, L. L. de Vogel, J. P. J. J. Hegmans, B. H. Stricker, S. Philipsen, J. G. J. V. Aerts

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Oncogenic Ras is downregulated by ARHI and induces autophagy by Ras/AKT/mTOR pathway in glioblastoma

Chen Zhong, Mengting Shu, Junyi Ye, Xiaoxiong Wang, Xin Chen, Zhendong Liu, Wenyang Zhao, Boxian Zhao, Zhixing Zheng, Zhiqin Yin, Ming Gao, Haiqi Zhao, Kaikai Wang, Shiguang Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Everolimus in hormone receptor-positive metastatic breast cancer: PIK3CA mutation H1047R was a potential efficacy biomarker in a retrospective study

Zongbi Yi, Fei Ma, Binliang Liu, Xiuwen Guan, Lixi Li, Chunxiao Li, Haili Qian, Binghe Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Identification of genetic association between cardiorespiratory fitness and the trainability genes in childhood acute lymphoblastic leukemia survivors

Maxime Caru, Kateryna Petrykey, Simon Drouin, Patrick Beaulieu, Pascal St-Onge, Valérie Lemay, Laurence Bertout, Caroline Laverdiere, Gregor Andelfinger, Maja Krajinovic, Daniel Sinnett, Daniel Curnier

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinicopathologic predictors of metastasis of different regional lymph nodes in patients intraoperatively diagnosed with stage-I non-small cell lung cancer

Fei Zhao, Fu-Xi Zhen, Yue Zhou, Chen-Jun Huang, Yue Yu, Jun Li, Qi-Fan Li, Cheng-Xiang Zhu, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Liang Chen, Wei Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Role of delayed salvage bevacizumab at symptomatic progression of chemorefractory glioblastoma

Moire Cuncannon, Matthew Wong, Dasantha Jayamanne, Linxin Guo, Nicola Cove, Helen Wheeler, Michael Back

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

Kai Wang, Guanying Wang, Shangke Huang, Anqi Luo, Xin Jing, Gang Li, Yi Zhou, Xinhan Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Resilience and associated factors among Chinese patients diagnosed with oral cancer

Yuqin Gao, Lulu Yuan, Bochen Pan, Lie Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer

Zaiping Chen, Guiyang Wu, Fubo Ye, Guoping Chen, Qinghao Fan, Hao Dong, Xiongwen Zhu, Chongshan Wu

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Acral vascular necrosis associated with immune-check point inhibitors: case report with literature review

Karam Khaddour, Veerpal Singh, Maryna Shayuk

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The role of mSEPT9 in screening, diagnosis, and recurrence monitoring of colorectal cancer

Jie Sun, Fei Fei, Mingqing Zhang, Yuwei Li, Xipeng Zhang, Siwei Zhu, Shiwu Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical implications of a novel prognostic factor AIFM3 in breast cancer patients

Ang Zheng, Lin Zhang, Xinyue Song, Yuying Wang, Minjie Wei, Feng Jin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High methylation levels of PCDH10 predict poor prognosis in patients with pancreatic ductal adenocarcinoma

Maria Cristina Curia, Fabiana Fantini, Rossano Lattanzio, Francesca Tavano, Francesco Di Mola, Mauro Piantelli, Pasquale Battista, Pierluigi Di Sebastiano, Alessandro Cama

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Polymorphisms in IL-10 and TGF-β gene promoter are associated with lower risk to gastric cancer in a Mexican population

Cecilia Martínez-Campos, Kirvis Torres-Poveda, Margarita Camorlinga-Ponce, Lourdes Flores-Luna, Carmen Maldonado-Bernal, Vicente Madrid-Marina, Javier Torres

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway

Hui Bai, Chenchen Wang, Yu Qi, Jin Xu, Nan Li, Lili Chen, Bin Jiang, Xudong Zhu, Hanwen Zhang, Xiaoyu Li, Qing Yang, Junqing Ma, Yong Xu, Jingjing Ben, Qi Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

Machiko Kojima, Kenbun Sone, Katsutoshi Oda, Ryuji Hamamoto, Syuzo Kaneko, Shinya Oki, Asako Kukita, Hidenori Machino, Harunori Honjoh, Yoshiko Kawata, Tomoko Kashiyama, Kayo Asada, Michihiro Tanikawa, Mayuyo Mori-Uchino, Tetsushi Tsuruga, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada-Hiraike, Yutaka Osuga, Tomoyuki Fujii

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Preoperative maximum standardized uptake value and carbohydrate antigen 19–9 were independent predictors of pathological stages and overall survival in Chinese patients with pancreatic duct adenocarcinoma

Xinjin Gu, Ruiquan Zhou, Chenggang Li, Rong Liu, Zhiming Zhao, Yuanxing Gao, Yong Xu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Portrait of a cancer: mutational signature analyses for cancer diagnostics

Arne Van Hoeck, Niels H. Tjoonk, Ruben van Boxtel, Edwin Cuppen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Longitudinal evaluation of Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK), a symptom screening and management application

Emily Vettese, Sadie Cook, Dilip Soman, Susan Kuczynski, Brenda Spiegler, Hailey Davis, Nathan Duong, Tal Schechter, L. Lee Dupuis, Lillian Sung

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Long-term survival of an elderly patient with advanced gastric cancer after combination therapy: a case report and literature review

Qingwei Li, Xuejun Xu, Dan Su, Tianshuo Zhou, Guangyu Wang, Zhiwei Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Phase I study of high-dose ascorbic acid with mFOLFOX6 or FOLFIRI in patients with metastatic colorectal cancer or gastric cancer

Feng Wang, Ming-Ming He, Zi-Xian Wang, Su Li, Ying Jin, Chao Ren, Si-Mei Shi, Bing-Tian Bi, Shuang-Zhen Chen, Zhi-Da Lv, Jia-Jia Hu, Zhi-Qiang Wang, Feng-Hua Wang, De-Shen Wang, Yu-Hong Li, Rui-Hua Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: a nationwide cohort study

Chien-Liang Lin, Shang-Yin Wu, Wen-Tsung Huang, Yin-Hsun Feng, Ching-Yi Yiu, Wei-Fan Chiang, Sheng-Yow Ho, Sheng-Hsiang Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Long-term efficacy and cost-effectiveness of blended cognitive behavior therapy for high fear of recurrence in breast, prostate and colorectal Cancer survivors: follow-up of the SWORD randomized controlled trial

Rens Burm, Belinda Thewes, Laura Rodwell, Wietske Kievit, Anne Speckens, Marieke van de Wal, Judith Prins

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Developing a real-time electronic symptom monitoring system for patients after discharge following cancer-related surgery

Kerry N. L. Avery, Hollie S. Richards, Amanda Portal, Trudy Reed, Ruth Harding, Robert Carter, Leon Bamforth, Kate Absolom, Elaine O’Connell Francischetto, Galina Velikova, Jane M. Blazeby

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis

Lingming Yu, Guangyu Tao, Lei Zhu, Gang Wang, Ziming Li, Jianding Ye, Qunhui Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

Xin Yang, Kuo Zhang, Caiji Zhang, Rongxue Peng, Chengming Sun

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prevalence and factors associated with major depressive disorder in children and adolescents at the Uganda Cancer Institute

Benedict Akimana, Catherine Abbo, Joyce Balagadde-Kambugu, Etheldreda Nakimuli-Mpungu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel integrated platform for the identification of surgical margins in oral squamous cell carcinoma: results from a prospective single-institution series

Alessandro Baj, Nicola Fusco, Alessandro Bolzoni, Daniela Carioli, Camilla Mazzucato, Alice Faversani, Lorenzo Bresciani, Marco Maggioni, Pasquale Capaccio

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Overall survival of patients with recurrent pancreatic cancer treated with systemic therapy: a retrospective study

Olumide B. Gbolahan, Yan Tong, Amikar Sehdev, Bert O’Neil, Safi Shahda

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparison between opportunistic and organised breast cancer mammography screening in the Swiss canton of Fribourg

Sarah Peisl, Stefan Zimmermann, Bertrand Camey, Daniel Betticher, Christine Bouchardy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The primary lesion apparent diffusion coefficient is a prognostic factor for locoregionally advanced nasopharyngeal carcinoma: a retrospective study

Tao-xiang Huang, Nian Lu, Shan-shan Lian, Hui Li, Shao-han Yin, Zhi-jun Geng, Chuan-miao Xie

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

The STELLAR trial protocol: a prospective multicentre trial for Richter’s syndrome consisting of a randomised trial investigation CHOP-R with or without acalabrutinib for newly diagnosed RS and a single-arm platform study for evaluation of novel agents in relapsed disease

Niamh Appleby, Toby A. Eyre, Maite Cabes, Aimee Jackson, Rebecca Boucher, Francesca Yates, Sonia Fox, Andrew Rawstron, Peter Hillmen, Anna Schuh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A comprehensive approach to rehabilitation interventions following breast cancer treatment - a systematic review of systematic reviews

U. Olsson Möller, I. Beck, L. Rydén, M. Malmström

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor

Chia-Chi Liu, Ching-Fang Yu, Shu-Chi Wang, Hsueh-Yin Li, Chiu-Min Lin, Hsia-Han Wang, Carmen Abate, Chi-Shiun Chiang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Raman spectroscopy detects metabolic signatures of radiation response and hypoxic fluctuations in non-small cell lung cancer

Samantha J. Van Nest, Leah M. Nicholson, Nils Pavey, Mathew N. Hindi, Alexandre G. Brolo, Andrew Jirasek, Julian J. Lum

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Predictors of distant metastasis in parotid acinic cell carcinoma

Qigen Fang, Junfu Wu, Wei Du, Xu Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of lymphovascular invasion in patients with squamous cell carcinoma of the penis following surgery

Kai Li, Jian Sun, Xuedong Wei, Guang Wu, Fei Wang, Caibin Fan, Hexing Yuan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Both chronic HBV infection and naturally acquired HBV immunity confer increased risks of B-cell non-Hodgkin lymphoma

Xi Zhou, Huaxiong Pan, Peng Yang, Pian Ye, Haiyan Cao, Hao Zhou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Postoperative radiotherapy is effective in improving survival of patients with stage pIII-N2 non-small-cell lung Cancer after pneumonectomy

Wenhui Wang, Yu Men, Jianyang Wang, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Qinfu Feng, Jima Lv, Jun Liang, Nan Bi, Shugeng Gao, Luhua Wang, Zhouguang Hui

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

Rebeca Burgos-Panadero, Inmaculada Noguera, Adela Cañete, Samuel Navarro, Rosa Noguera

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genetic associations between the miRNA polymorphisms miR-130b (rs373001), miR-200b (rs7549819), and miR-495 (rs2281611) and colorectal cancer susceptibility

Eun-Gyo Kim, Jung Oh Kim, Han Sung Park, Chang Soo Ryu, Jisu Oh, Hak Hoon Jun, Jong Woo Kim, Nam Keun Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Objective evaluation of clinical outcomes of laparoscopy-assisted pylorus-preserving gastrectomy for middle-third early gastric cancer

Xiang Xia, Jia Xu, Chunchao Zhu, Hui Cao, Fengrong Yu, Gang Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparison of weekly and triweekly cisplatin regimens during concurrent chemoradiotherapy for nasopharyngeal carcinoma

Kailin Wang, Jun Dong, Shasha He, Xia Wang, Chang Jiang, Pili Hu, Jiangui Guo, Xiuyu Cai, Xicheng Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Genetic polymorphisms of vascular endothelial growth factor (VEGF) associated with gastric cancer recurrence after curative resection with adjuvant chemotherapy

Yeon-Ji Kim, Woo Chul/ Chung, Kyong-Hwa Jun, Hyung-Min Chin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Natural killer cells and pigment epithelial-derived factor control the infiltrative and nodular growth of hepatic metastases in an Orthotopic murine model of ocular melanoma

Nyasia M. Jones, Hua Yang, Qing Zhang, Vanessa M. Morales-Tirado, Hans E. Grossniklaus

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Regulation of cisplatin-resistant head and neck squamous cell carcinoma by the SRC/ETS-1 signaling pathway

Zejia Yang, Jipei Liao, Brandon A. Carter-Cooper, Rena G. Lapidus, Kevin J. Cullen, Hancai Dan

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Decitabine plus CLAG chemotherapy as a bridge to haploidentical transplantation in the setting of acute myeloid leukemia relapse after HLA-matched sibling transplantation: a case report

Mengqi Jin, Yongxian Hu, Wenjun Wu, Yi Luo, Yamin Tan, Jian Yu, Aiyun Jin, Luxin Yang, He Huang, Guoqing Wei

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

The LACOG-0415 phase II trial: abiraterone acetate and ADT versus apalutamide versus abiraterone acetate and apalutamide in patients with advanced prostate cancer with non-castration testosterone levels

Gustavo Werutsky, Fernando Cotait Maluf, Eduardo Henrique Cronemberger, Vinicius Carrera Souza, Suelen Patricia dos Santos Martins, Fábio Peixoto, Oren Smaletz, Fábio Schutz, Daniel Herchenhorn, Telma Santos, Flavio Mavignier Carcano, David Queiroz Muniz, Paulo R. S. Nunes Filho, Facundo Zaffaroni, Carlos Barrios, André Fay

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

High level of circulating vitamin D during neoadjuvant therapy may lower risk of metastatic progression in high-risk rectal cancer

Hanna Abrahamsson, Alina C. Porojnicu, Jonas C. Lindstrøm, Svein Dueland, Kjersti Flatmark, Knut H. Hole, Therese Seierstad, Johan Moan, Kathrine Røe Redalen, Sebastian Meltzer, Anne Hansen Ree

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Pazopanib has equivalent anti-tumor effectiveness and lower Total costs than Sunitinib for treating metastatic or advanced renal cell carcinoma: a meta-analysis

Huan Deng, Yu Huang, Zhengdong Hong, Xuhui Yuan, Zhi Cao, Yiping Wei, Wenxiong Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Collagen organization of renal cell carcinoma differs between low and high grade tumors

Sara L. Best, Yuming Liu, Adib Keikhosravi, Cole R. Drifka, Kaitlin M. Woo, Guneet S. Mehta, Marie Altwegg, Terra N. Thimm, Matthew Houlihan, Jeremy S. Bredfeldt, E. Jason Abel, Wei Huang, Kevin W. Eliceiri

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer

Alexandria C. Rutkovsky, Elizabeth S. Yeh, Stephen T. Guest, Victoria J. Findlay, Robin C. Muise-Helmericks, Kent Armeson, Stephen P. Ethier

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: A multicenter phase III study comparing Simultaneous Integrated Boost (SIB) radiotherapy concurrent and consolidated with S-1 versus SIB alone in elderly patients with esophageal and esophagogastric cancer – the 3JECROG P-01 study protocol

Chen Li, Xiaomin Wang, Xin Wang, Chun Han, Ping Wang, Qingsong Pang, Junqiang Chen, Xinchen Sun, Lan Wang, Wencheng Zhang, Yu Lin, Xiaolin Ge, Zongmei Zhou, Wenjie Ni, Xiao Chang, Jun Liang, Lei Deng, Wenqing Wang, Yidian Zhao, Zefen Xiao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association of newly identified genetic variant rs2853677 of TERT with non-small cell lung cancer and leukemia in population of Jammu and Kashmir, India

Gh. Rasool Bhat, Amrita Bhat, Sonali Verma, Itty Sethi, Ruchi Shah, Varun Sharma, Khursheed A. Dar, Deepak Abrol, Subiya Kaneez, Sandeep Kaul, Ramesh Ganju, Rakesh Kumar

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

EORTC-1203-GITCG - the “INNOVATION”-trial: Effect of chemotherapy alone versus chemotherapy plus trastuzumab, versus chemotherapy plus trastuzumab plus pertuzumab, in the perioperative treatment of HER2 positive, gastric and gastroesophageal junction adenocarcinoma on pathologic response rate: a randomized phase II-intergroup trial of the EORTC-Gastrointestinal Tract Cancer Group, Korean Cancer Study Group and Dutch Upper GI-Cancer group

Anna Dorothea Wagner, Heike I. Grabsch, Murielle Mauer, Sandrine Marreaud, Carmela Caballero, Peter Thuss-Patience, Lothar Mueller, Annelie Elme, Markus Hermann Moehler, Uwe Martens, Yoon-Koo Kang, Sun Young Rha, Annemieke Cats, Masanori Tokunaga, Florian Lordick

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Association of breast and gut microbiota dysbiosis and the risk of breast cancer: a case-control clinical study

Julio Plaza-Díaz, Ana I. Álvarez-Mercado, Carmen M Ruiz-Marín, Iris Reina-Pérez, Alejandro J. Pérez-Alonso, María Belén Sánchez-Andujar, Pablo Torné, Tania Gallart-Aragón, María Teresa Sánchez-Barrón, Saturnino Reyes Lartategui, Federico García, Natalia Chueca, Ana Moreno-Delgado, Katia Torres-Martínez, María José Sáez-Lara, Cándido Robles-Sánchez, Mariana F. Fernández, Luis Fontana

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells

Eun Byeol Jo, Young Sang Lee, Hyunjoo Lee, Jae Berm Park, Hyojun Park, Yoon-La Choi, Doopyo Hong, Sung Joo Kim

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The short-term efficacy of no-touch radiofrequency ablation in treating cirrhosis-based small hepatocellular carcinoma

Yuelong Chai, Kun Li, Chang Zhang, Shihan Chen, Kuansheng Ma

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Association between high-resolution MRI-detected extramural vascular invasion and tumour microcirculation estimated by dynamic contrast-enhanced MRI in rectal cancer: preliminary results

Yan Chen, Xinyue Yang, Ziqiang Wen, Yiyan Liu, Baolan Lu, Shenping Yu, Xiaojuan Xiao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell

Qingling Song, Fengtao Yi, Yuhong Zhang, Daniel K. Jun Li, Yaxun Wei, Han Yu, Yi Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comparison of minimally invasive Ivor Lewis esophagectomy and left transthoracic esophagectomy in esophageal squamous cell carcinoma patients: a propensity score-matched analysis

Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen, Ming Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer cell lipid class homeostasis is altered under nutrient-deprivation but stable under hypoxia

Jan Lisec, Carsten Jaeger, Rida Rashid, Rimsha Munir, Nousheen Zaidi

01.12.2019 | Technical advance | Ausgabe 1/2019 Open Access

An image-based assay to quantify changes in proliferation and viability upon drug treatment in 3D microenvironments

Vasanth S. Murali, Bo-Jui Chang, Reto Fiolka, Gaudenz Danuser, Murat Can Cobanoglu, Erik S. Welf

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PD-1 high expression predicts lower local disease control in stage IV M0 nasopharyngeal carcinoma

Feng Jiang, Wei Yu, Fanrui Zeng, Guoping Cheng, Jing Xu, Shifeng Yang, Yongjie Shui, Dang Wu, Xiao-fang Yu, Qichun Wei

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Rationale and design of the German-speaking myeloma multicenter group (GMMG) trial HD6: a randomized phase III trial on the effect of elotuzumab in VRD induction/consolidation and lenalidomide maintenance in patients with newly diagnosed myeloma

Hans Salwender, Uta Bertsch, Katja Weisel, Jan Duerig, Christina Kunz, Axel Benner, Igor W. Blau, Marc Steffen Raab, Jens Hillengass, Dirk Hose, Stefanie Huhn, Michael Hundemer, Mindaugas Andrulis, Anna Jauch, Andrea Seidel-Glaetzer, Hans-Walter Lindemann, Manfred Hensel, Stefan Fronhoffs, Uwe Martens, Timon Hansen, Mohammed Wattad, Ullrich Graeven, Markus Munder, Roland Fenk, Mathias Haenel, Christof Scheid, Hartmut Goldschmidt

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

Yun Li, Xiaoli Yan, Jiajian Shi, Yun He, Jie Xu, Liying Lin, Wannan Chen, Xinjian Lin, Xu Lin

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

PRIMMO study protocol: a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer

Sandra Tuyaerts, An M. T. Van Nuffel, Eline Naert, Peter A. Van Dam, Peter Vuylsteke, Alex De Caluwé, Sandrine Aspeslagh, Piet Dirix, Lien Lippens, Emiel De Jaeghere, Frédéric Amant, Katrien Vandecasteele, Hannelore Denys

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CDKN2A copy number and p16 expression in malignant pleural mesothelioma in relation to asbestos exposure

Eeva Kettunen, Sauli Savukoski, Kaisa Salmenkivi, Tom Böhling, Esa Vanhala, Eeva Kuosma, Sisko Anttila, Henrik Wolff

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemia

H. Jonathan G. Lindström, Astrid S. de Wijn, Ran Friedman

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Effect of prior cancer on survival outcomes for patients with pancreatic adenocarcinoma: a propensity score analysis

Chaobin He, Yu Zhang, Zhiyuan Cai, Xiaojun Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

ERO1α is a novel endogenous marker of hypoxia in human cancer cell lines

Norio Takei, Akihiro Yoneda, Marina Kosaka, Kaori Sakai-Sawada, Yasuaki Tamura

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The effectiveness of TDF versus ETV on incidence of HCC in CHB patients: a meta analysis

Zeyu Zhang, Yufan Zhou, Jiajin Yang, Kuan Hu, Yun Huang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Geographical patterns of the incidence and mortality of colorectal cancer in mainland Portugal municipalities (2007–2011)

R. Roquette, M. Painho, B. Nunes

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Endoscopic features and associated histology of an basaloid squamous cell carcinoma of the esophagus at the very early stage

Lianjun Di, Kuang-I Fu, Xinglong Wu, Xuemei Liu, Rui Xie, Rong Zhu, Biguang Tuo

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Generalized crystal-storing histiocytosis with diffuse large B-cell lymphoma and monoclonal gammopathy in a Chinese elderly woman: a case report

Qing Tao, Wenyan Zhang, Zihang Chen, Limin Gao, Jiaqi Yan, Mi Wang, Chunxiang Xiang, Weiping Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The association of germline variants with chronic lymphocytic leukemia outcome suggests the implication of novel genes and pathways in clinical evolution

Adrián Mosquera Orgueira, Beatriz Antelo Rodríguez, Natalia Alonso Vence, José Ángel Díaz Arias, Nicolás Díaz Varela, Manuel Mateo Pérez Encinas, Catarina Allegue Toscano, Elena María Goiricelaya Seco, Ángel Carracedo Álvarez, José Luis Bello López

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A survivin-responsive, conditionally replicating adenovirus induces potent cytocidal effects in adult T-cell leukemia/lymphoma

Shinsuke Suzuki, Hiroki Kofune, Kimiharu Uozumi, Makoto Yoshimitsu, Naomichi Arima, Kenji Ishitsuka, Shin-ichi Ueno, Ken-ichiro Kosai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer

Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre, Paul Anthony Ellis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Lineage relationship between prostate adenocarcinoma and small cell carcinoma

Adelle D. Kanan, Eva Corey, Ricardo Z. N. Vêncio, Arjun Ishwar, Alvin Y. Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review

Mark T. J. van Bussel, Jos H. Beijnen, Dieta Brandsma

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis – results from a registry-based study from Germany

Bernd Holleczek, Christa Stegmaier, Julia C. Radosa, Erich-Franz Solomayer, Hermann Brenner

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer

Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Matsubara, Takuya Ayabe

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Validity and reliability of the EQ-5D-5 L in family caregivers of leukemia patients

Limin Li, Chaojie Liu, Xiuzhi Cai, Hongjuan Yu, Xueyun Zeng, Mingjie Sui, Erwei Zheng, Yang Li, Jiao Xu, Jin Zhou, Weidong Huang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adjuvant cytokine-induced killer cell immunotherapy for hepatocellular carcinoma: a propensity score-matched analysis of real-world data

Jun Sik Yoon, Byeong Geun Song, Jeong-Hoon Lee, Hyo Young Lee, Sun Woong Kim, Young Chang, Yun Bin Lee, Eun Ju Cho, Su Jong Yu, Dong Hyun Sinn, Yoon Jun Kim, Joon Hyeok Lee, Jung-Hwan Yoon

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Early prostate-specific antigen response post-abiraterone as predictor of overall survival in metastatic castrate-resistant prostate cancer

Joshua P. Schiff, Patrick Cotogno, Allison Feibus, Peter Steinwald, Elisa Ledet, Brian Lewis, Oliver Sartor

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Polymorphisms in the CCR5 promoter associated with cervical intraepithelial neoplasia in a Chinese Han population

Shuyuan Liu, Jun Chen, Zhiling Yan, Shuying Dai, Chuanyin Li, Yufeng Yao, Li Shi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical use of tumor biomarkers in prediction for prognosis and chemotherapeutic effect in esophageal squamous cell carcinoma

Yuchong Yang, Xuanzhang Huang, Likun Zhou, Ting Deng, Tao Ning, Rui Liu, Le Zhang, Ming Bai, Haiyang Zhang, Hongli Li, Yi Ba

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis

Lotfolah Saed, Fatemeh Varse, Hamid Reza Baradaran, Yousef Moradi, Sorour Khateri, Emilie Friberg, Zaher Khazaei, Saeedeh Gharahjeh, Shahrzad Tehrani, Amir-Babak Sioofy-Khojine, Zahra Najmi

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A randomized phase II study of nutritional and exercise treatment for elderly patients with advanced non-small cell lung or pancreatic cancer: the NEXTAC-TWO study protocol

Satoru Miura, Tateaki Naito, Shuichi Mitsunaga, Katsuhiro Omae, Keita Mori, Toshimi Inano, Teiko Yamaguchi, Noriatsu Tatematsu, Taro Okayama, Ayumu Morikawa, Takako Mouri, Hisashi Tanaka, Madoka Kimura, Hisao Imai, Takuro Mizukami, Akira Imoto, Chihiro Kondoh, Shinsuke Shiotsu, Hiroyuki Okuyama, Makoto Ueno, Toshiaki Takahashi, Tetsuya Tsuji, Hideki Aragane, Akio Inui, Takashi Higashiguchi, Koichi Takayama

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Multidisciplinary approach to rare primary cardiac sarcoma: a case report and review

Audrone Vaitiekiene, Domas Vaitiekus, Laura Urbonaite, Antanas Jankauskas, Justina Portacenko, Tomas Lapinskas, Rimantas Benetis, Adakrius Siudikas, Audrone Veikutiene, Lina Poskiene, Ausra Kavoliuniene, Rasa Janciauskiene, Laimonas Jarusevicius, Elona Juozaityte, Remigijus Zaliunas, Egle Ereminiene

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer

Chao Dong, Jing Sun, Sha Ma, Guoying Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma

Lars M. Schiffmann, Heike Göbel, Heike Löser, Fabian Schorn, Jan Paul Werthenbach, Hans F. Fuchs, Patrick S. Plum, Marc Bludau, Thomas Zander, Wolfgang Schröder, Christiane J. Bruns, Hamid Kashkar, Alexander Quaas, Florian Gebauer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth

Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan, Kensei Nishida

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

First-line single-agent regorafenib in frail patients with metastatic colorectal cancer: a pilot phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)

A. Carrato, M. Benavides, B. Massutí, R. Ferreiro-Monteagudo, P. García Alfonso, E. Falcó, M. Reboredo, T. Cano, J. Gallego, J. M. Viéitez, L. Layos, A. Salud, E. Polo, E. Dotor, G. Durán-Ogalla, M. Rodriguez-Garrote, A. Calvo, E. Grande, E. Aranda

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma

Bo Fan, Wei Wang, Xianping Zhang, Min Sun, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Qun Wang, Na Yu, Xiancheng Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations

Georgios N. Tsaousis, Eirini Papadopoulou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Stavroula Kampouri, Nikolaos Diamantopoulos, Theofanis Floros, Rodoniki Iosifidou, Ourania Katopodi, Anna Koumarianou, Christos Markopoulos, Konstantinos Papazisis, Vasileios Venizelos, Ioannis Xanthakis, Grigorios Xepapadakis, Eugeniu Banu, Dan Tudor Eniu, Serban Negru, Dana Lucia Stanculeanu, Andrei Ungureanu, Vahit Ozmen, Sualp Tansan, Mehmet Tekinel, Suayib Yalcin, George Nasioulas

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors

Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter, John Foley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intracranial aneurysms formation after radiotherapy for head and neck cancer: a 10-year nationwide follow-up study

Wei-Hsun Yang, Yao-Hsu Yang, Pau-Chung Chen, Ting-Chung Wang, Ko-Jung Chen, Chun-Yu Cheng, Chia-Hsuan Lai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Clinical and prognostic implications of pretreatment albumin to C-reactive protein ratio in patients with hepatocellular carcinoma

Mian-Tao Wu, Su-Yin He, Shu-Lin Chen, Lin-Fang Li, Zheng-Qiang He, Yuan-Ying Zhu, Xia He, Hao Chen

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report

Michael A. Cardis, Hong Jiang, Julius Strauss, James L. Gulley, Isaac Brownell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte, Scott H. Robbins

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer

Yaping Yang, Ying Wang, Heran Deng, Cui Tan, Qian Li, Zhanghai He, Wei Wei, Enxiang Zhou, Qiang Liu, Jieqiong Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells

Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara, Yasutoshi Tatsumi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis

Vicky C. Chang, Michelle Cotterchio, Edwin Khoo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors

Magdalena Zakrzewska, Renata Gruszka, Konrad Stawiski, Wojciech Fendler, Joanna Kordacka, Wiesława Grajkowska, Paweł Daszkiewicz, Paweł P. Liberski, Krzysztof Zakrzewski

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central America

Ricardo L. Dominguez, Charlotte B. Cherry, Dago Estevez-Ordonez, Robertino Mera, Veronica Escamilla, Michael Pawlita, Tim Waterboer, Keith T. Wilson, Richard M. Peek, Gloria Tavera, Scott M. Williams, Margaret L. Gulley, Michael Emch, Douglas R. Morgan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A prospective observational study to assess PD-L1 expression in small biopsy samples for non-small-cell lung cancer

Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi, Masamichi Mineshita

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study

Willem Jan van Weelden, Kristine Eldevik Fasmer, Ingvild L. Tangen, Joanna IntHout, Karin Abbink, Antionius E. van Herwaarden, Camilla Krakstad, Leon F. A. G. Massuger, Ingfrid S. Haldorsen, Johanna M. A. Pijnenborg

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Real-world treatment patterns and adverse events in metastatic renal cell carcinoma from a large US claims database

Sumanta Pal, Jun Gong, Shivani K. Mhatre, Shih-Wen Lin, Andy Surinach, Sarika Ogale, Rini Vohra, Herschel Wallen, Daniel George

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases

Mariana Bustamante Eduardo, Vlad Popovici, Sara Imboden, Stefan Aebi, Nadja Ballabio, Hans Jörg Altermatt, Andreas Günthert, Rolf Jaggi

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The value of 3D visualization operative planning system in ultrasound-guided percutaneous microwave ablation for large hepatic hemangiomas: a clinical comparative study

Xin Li, Chao An, Fangyi Liu, Zhigang Cheng, Zhiyu Han, Xiaoling Yu, Linan Dong, Jie Yu, Ping Liang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Comprehensive mutation detection of BRCA1/2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese women

Wen-Ming Cao, Ya-Bing Zheng, Yun Gao, Xiao-Wen Ding, Yan Sun, Yuan Huang, Cai-Jin Lou, Zhi-Wen Pan, Guang Peng, Xiao-Jia Wang

01.12.2019 | Technical advance | Ausgabe 1/2019 Open Access

Advantages of the net benefit regression framework for trial-based economic evaluations of cancer treatments: an example from the Canadian Cancer Trials Group CO.17 trial

Jeffrey S. Hoch, Annette Hay, Wanrudee Isaranuwatchai, Kednapa Thavorn, Natasha B. Leighl, Dongsheng Tu, Logan Trenaman, Carolyn S. Dewa, Chris O’Callaghan, Joseph Pater, Derek Jonker, Bingshu E. Chen, Nicole Mittmann

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma

Ting-Xun Lu, Shuang Wu, Dong-Yan Cai, Ting-Ting Hong, Ying Zhang, Hua-Qiang Gao, Hai-Ying Hua, Xiao-Hong Wu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Advantages of using reduced-volume intensity modulated radiation therapy for the treatment of nasopharyngeal carcinoma: a retrospective paired study

Fang Liu, Ting Luo, Tao Jin, Jiahui Zhang, Zhongzheng Xiang, Ruonan Yan, Li Xie, Xin Wu, Hong Zhang, Feng Wang, Ping Li, Lei Liu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia, Jun Sun

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Aberrant expression of N-glycolyl GM3 ganglioside is associated with the aggressive biological behavior of human sarcomas

Daniel Pilco-Janeta, Myriam De la Cruz Puebla, Jorge Soriano, Marta Osorio, Iraida Caballero, Adanays Calvo Pérez, Laynes Savon, Natalia Cremades, Rancés Blanco, Adriana Carr

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

Kristi Läll, Maarja Lepamets, Marili Palover, Tõnu Esko, Andres Metspalu, Neeme Tõnisson, Peeter Padrik, Reedik Mägi, Krista Fischer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis

Xiaoying Sun, Raheleh Roudi, Ting Dai, Shangya Chen, Bin Fan, Hongjin Li, Yaqiong Zhou, Min Zhou, Bo Zhu, Chengqian Yin, Bin Li, Xin Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The safety and tolerability of combined immune checkpoint inhibitors (anti-PD-1/PD-L1 plus anti-CTLA-4): a systematic review and meta-analysis

Lihu Gu, Parikshit Asutosh Khadaroo, Hui Su, Liya Kong, Liangliang Chen, Xianfa Wang, Xinlong Li, Hepan Zhu, Xin Zhong, Junhai Pan, Manman Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Radiotherapy for inferior vena cava tumor thrombus in patients with hepatocellular carcinoma

Tzu-Hui Pao, Wei-Ting Hsueh, Wei-Lun Chang, Nai-Jung Chiang, Yih-Jyh Lin, Yi-Sheng Liu, Forn-Chia Lin

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells

Joshua Tordjman, Mousumi Majumder, Mehdi Amiri, Asma Hasan, David Hess, Peeyush K. Lala

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report

Takeo Kosaka, Hiroshi Hongo, Mototsugu Oya

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Evidence on the prevalence, incidence, mortality and trends of human papilloma virus-associated cancers in sub-Saharan Africa: systematic scoping review

Kabelo M. B. Lekoane, Desmond Kuupiel, Tivani P. Mashamba-Thompson, Themba G. Ginindza

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Development and validation of a model that includes two ultrasound parameters and the plasma D-dimer level for predicting malignancy in adnexal masses: an observational study

Maciej Stukan, Michał Badocha, Karol Ratajczak

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes

Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii, Joel A. Malek

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Cancer stigma and cancer screening attendance: a population based survey in England

Charlotte Vrinten, Ailish Gallagher, Jo Waller, Laura A. V. Marlow

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report

Eduard Callebout, Suzane Moura Ribeiro, Stephanie Laurent, Marc De Man, Liesbeth Ferdinande, Kathleen B. M. Claes, Joni Van der Meulen, Karen P. Geboes

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A prospective clinical trial on sorafenib treatment of hepatocellular carcinoma before liver transplantation

Malin Sternby Eilard, Mats Andersson, Peter Naredi, Charalampos Geronymakis, Per Lindnér, Christian Cahlin, William Bennet, Magnus Rizell

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Adjuvant chemoradiation in pancreatic cancer: impact of radiotherapy dose on survival

Alessio G. Morganti, Francesco Cellini, Milly Buwenge, Alessandra Arcelli, Sergio Alfieri, Felipe A. Calvo, Riccardo Casadei, Savino Cilla, Francesco Deodato, Giancarmine Di Gioia, Mariacristina Di Marco, Lorenzo Fuccio, Federica Bertini, Alessandra Guido, Joseph M. Herman, Gabriella Macchia, Bert W. Maidment III, Robert C. Miller, Francesco Minni, Paolo Passoni, Chiara Valentini, Alessia Re, William F. Regine, Michele Reni, Massimo Falconi, Vincenzo Valentini, Gian Carlo Mattiucci

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Coverage of cancer services in Australia and providers’ views on service gaps: findings from a national cross-sectional survey

Jennifer Hunter, Caroline Smith, Geoff P. Delaney, Kate Templeman, Suzanne Grant, Jane M. Ussher

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Ae Kyung Park, Ji Yeoun Lee, Heesun Cheong, Vijay Ramaswamy, Sung-Hye Park, Marcel Kool, Ji Hoon Phi, Seung Ah Choi, Florence Cavalli, Michael D. Taylor, Seung-Ki Kim

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

A phase II randomized placebo-controlled double-blind study of salvage radiation therapy plus placebo versus SRT plus enzalutamide with high-risk PSA-recurrent prostate cancer after radical prostatectomy (SALV-ENZA)

Roche Kapoor, Matthew P. Deek, Riley McIntyre, Natasha Raman, Megan Kummerlowe, Iyah Chen, Matt Gaver, Hao Wang, Sam Denmeade, Tamara Lotan, Channing Paller, Mark Markowski, Michael Carducci, Mario Eisenberger, Tomasz M. Beer, Daniel Y. Song, Theodore L. DeWeese, Jason W. Hearn, Stephen Greco, Curtiland DeVille, Neil B. Desai, Elisabeth I. Heath, Stanley Liauw, Daniel E. Spratt, Arthur Y. Hung, Emmanuel S. Antonarakis, Phuoc T. Tran

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene

Iben Kümler, Eva Balslev, Jan Stenvang, Nils Brünner, Bent Ejlertsen, Erik Hugger Jakobsen, Dorte Lisbet Nielsen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations

Ji Young Park, Seung Hun Jang, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Jinwon Seo, Chang Youl Lee, Yousang Ko, Yong-Bum Park

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Treatment with somatostatin analogs induces differentially expressed let-7c-5p and mir-3137 in small intestine neuroendocrine tumors

Florian Bösch, Alexandr V. Bazhin, Sabine Heublein, Katharina Brüwer, Thomas Knösel, Florian P. Reiter, Christoph J. Auernhammer, Markus O. Guba, Christine Spitzweg, Jens Werner, Martin K. Angele

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo

Yifei Feng, Wenwei Qian, Yue Zhang, Wen Peng, Jie Li, Qiou Gu, Dongjian Ji, Zhiyuan Zhang, Qingyuan Wang, Dongsheng Zhang, Yueming Sun

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MiR-890 inhibits proliferation and invasion and induces apoptosis in triple-negative breast cancer cells by targeting CD147

Cheng Wang, Cheng Xu, Ruijie Niu, Guangfu Hu, Zhangyuan Gu, Zhigang Zhuang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Health-related quality of life in patients receiving first-line eribulin mesylate with or without trastuzumab for locally recurrent or metastatic breast cancer

Lee Schwartzberg, Kristi McIntyre, Sharon Wilks, Shannon Puhalla, Joyce O’Shaughnessy, Erhan Berrak, Yaohua He, Linda Vahdat

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Monitoring of circulating tumor DNA and its aberrant methylation in the surveillance of surgical lung Cancer patients: protocol for a prospective observational study

Guannan Kang, Kezhong Chen, Fan Yang, Shannon Chuai, Heng Zhao, Kai Zhang, Bingsi Li, Zhihong Zhang, Jun Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Smoking cessation care can translate to lower hazard of death in the short-run in cancer patients - a retrospective cohort study to demonstrate the value of smoking cessation services within the treatment phase of cancer

F. I. Hawari, N. A. Obeidat, D. Rimawi, K. Jamal

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential

Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer, Jin-Xiong She

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial

Sarah R. Brown, Andrew Hall, Hannah L. Buckley, Louise Flanagan, David Gonzalez de Castro, Kate Farnell, Laura Moss, Rebecca Gregory, Kate Newbold, Yong Du, Glenn Flux, Jonathan Wadsley

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Choice of immobilization of stereotactic body radiotherapy in lung tumor patient by BMI

Guofu Chen, Baiqiang Dong, Guoping Shan, Xiuqin Zhang, Huarong Tang, Yuchen Li, Zhenhua Wang, Wei Xu, Gang Xu, Guiming Yan, Feiyan Zhang, Xiao Hu, Jun Yang, Yujin Xu, Ming Chen, Jin Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer

Minna Sopo, Maarit Anttila, Kirsi Hämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula, Hanna Sallinen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Evaluating diagnostic strategies for early detection of cancer: the CanTest framework

Fiona M. Walter, Matthew J. Thompson, Ian Wellwood, Gary A. Abel, William Hamilton, Margaret Johnson, Georgios Lyratzopoulos, Michael P. Messenger, Richard D. Neal, Greg Rubin, Hardeep Singh, Anne Spencer, Stephen Sutton, Peter Vedsted, Jon D. Emery

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

PRAF2 overexpression predicts poor prognosis and promotes tumorigenesis in esophageal squamous cell carcinoma

Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao, Xiaofei Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

miR-520d-5p can reduce the mutations in hepatoma cancer cells and iPSCs-derivatives

Norimasa Miura, Yoshitaka Ishihara, Yugo Miura, Mai Kimoto, Keigo Miura

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Exploring serum and immunoglobulin G N-glycome as diagnostic biomarkers for early detection of breast cancer in Ethiopian women

Abrha G. Gebrehiwot, Daniel Seifu Melka, Yimenashu Mamo Kassaye, Tufa Gemechu, Wajana Lako, Hiroshi Hinou, Shin-Ichiro Nishimura

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Anticancer effect of berberine based on experimental animal models of various cancers: a systematic review and meta-analysis

Jianhao Xu, Yuming Long, Liwei Ni, Xuya Yuan, Na Yu, Runhong Wu, Jialong Tao, Yusong Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Systematization of analytical studies of polycythemia vera, essential thrombocythemia and primary myelofibrosis, and a meta-analysis of the frequency of JAK2, CALR and MPL mutations: 2000–2018

Mónica Mejía-Ochoa, Paola Andrea Acevedo Toro, Jaiberth Antonio Cardona-Arias

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A hypothesized TNM staging system based on the number and location of positive lymph nodes may better reflect the prognosis for patients with NSCLC

Xiaoling Shang, Jia Liu, Zhenxiang Li, Jiamao Lin, Haiyong Wang

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Molecular genetic characterization reveals linear tumor evolution in a pulmonary sarcomatoid carcinomas patient with a novel PHF20-NTRK1 fusion: a case report

Jianjun Ge, Bin Yao, Jia Huang, Xue Wu, Hua Bao, Qiuxiang Ou, Yang W. Shao, Jun Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Probabilistic modeling of personalized drug combinations from integrated chemical screen and molecular data in sarcoma

Noah E. Berlow, Rishi Rikhi, Mathew Geltzeiler, Jinu Abraham, Matthew N. Svalina, Lara E. Davis, Erin Wise, Maria Mancini, Jonathan Noujaim, Atiya Mansoor, Michael J. Quist, Kevin L. Matlock, Martin W. Goros, Brian S. Hernandez, Yee C. Doung, Khin Thway, Tomohide Tsukahara, Jun Nishio, Elaine T. Huang, Susan Airhart, Carol J. Bult, Regina Gandour-Edwards, Robert G. Maki, Robin L. Jones, Joel E. Michalek, Milan Milovancev, Souparno Ghosh, Ranadip Pal, Charles Keller

01.12.2019 | Case report | Ausgabe 1/2019 Open Access

Multiple secondary cauda equina non-Hodgkin’s lymphoma: a case report and literature review

Yunchao Ban, Zhitao Jing, Jingyu Zou

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer

Wenfeng Fang, Yihua Huang, Shaodong Hong, Zhonghan Zhang, Minghui Wang, Jiadi Gan, Wenjing Wang, Honglin Guo, Kai Wang, Li Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

Manoj Amrutkar, Monica Aasrum, Caroline S. Verbeke, Ivar P. Gladhaug

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The expression of S100A8/S100A9 is inducible and regulated by the Hippo/YAP pathway in squamous cell carcinomas

Yunguang Li, Fei Kong, Chang Jin, Enze Hu, Qirui Shao, Jin Liu, Dacheng He, Xueyuan Xiao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A new mouse model to study the role of ectopic Nanos3 expression in cancer

Vanessa Andries, Evi De Keuckelaere, Katrien Staes, Tino Hochepied, Joachim Taminau, Kelly Lemeire, Philippe Birembaut, Geert Berx, Frans van Roy

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma

Mengqiao Xu, Xia Wang, Yanfang Pan, Xingpeng Zhao, Bin Yan, Changgeng Ruan, Lijun Xia, Yiming Zhao

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Computational analysis of receptor tyrosine kinase inhibitors and cancer metabolism: implications for treatment and discovery of potential therapeutic signatures

Jian Li, Kathrin Halfter, Mengying Zhang, Christian Saad, Kai Xu, Bernhard Bauer, Yijiang Huang, Lei Shi, Ulrich R. Mansmann

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic assessment of breast carcinoma submitted to neoadjuvant chemotherapy with pathological non-complete response

Uanderson Resende, César Cabello, Susana Oliveira Botelho Ramalho, Luiz Carlos Zeferino

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer

Jinzhi Lai, Hainan Yang, Yanyang Zhu, Mei Ruan, Yayu Huang, Qiuyu Zhang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Circulating tumor cell and cell-free RNA capture and expression analysis identify platelet-associated genes in metastatic lung cancer

Tim N. Beck, Yanis A. Boumber, Charu Aggarwal, Jianming Pei, Catherine Thrash-Bingham, Patricia Fittipaldi, Ramillya Vlasenkova, Chandra Rao, Hossein Borghaei, Massimo Cristofanilli, Ranee Mehra, Ilya Serebriiskii, R. Katherine Alpaugh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Prognostic value of TOP2A in bladder urothelial carcinoma and potential molecular mechanisms

Shuxiong Zeng, Anwei Liu, Lihe Dai, Xiaowen Yu, Zhensheng Zhang, Qiao Xiong, Jun Yang, Fei Liu, Jinshan Xu, Yongping Xue, Yinghao Sun, Chuanliang Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Analysis of the transcriptomic features of microsatellite instability subtype colon cancer

Haiwei Wang, Xinrui Wang, Liangpu Xu, Ji Zhang, Hua Cao

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Study protocol of a randomized phase III trial of comparing preoperative chemoradiation with preoperative chemotherapy in patients with locally advanced gastric cancer or esophagogastric junction adenocarcinoma: PREACT

Xiaowen Liu, Jiejie Jin, Hong Cai, Hua Huang, Guangfa Zhao, Ye Zhou, Jianghong Wu, Chunyan Du, Ziwen Long, Yantian Fang, Mingze Ma, Guichao Li, Menglong Zhou, Jiliang Yin, Xiaodong Zhu, Ji zhu, Weiqi Sheng, Dan Huang, Hui Zhu, Zhaozhen Zhang, Qi Lu, Li Xie, Zhen Zhang, Yanong Wang

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A subtype of oral, laryngeal, esophageal, and lung, squamous cell carcinoma with high levels of TrkB-T1 neurotrophin receptor mRNA

Yalu Zhou, Saurabh Sinha, Joel L. Schwartz, Guy R. Adami

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

Robot-assisted esophagectomy (RAE) versus conventional minimally invasive esophagectomy (MIE) for resectable esophageal squamous cell carcinoma: protocol for a multicenter prospective randomized controlled trial (RAMIE trial, robot-assisted minimally invasive Esophagectomy)

Yang Yang, Xiaobin Zhang, Bin Li, Zhigang Li, Yifeng Sun, Teng Mao, Rong Hua, Yu Yang, Xufeng Guo, Yi He, Hecheng Li, Hezhong Chen, Lijie Tan

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

The role of DNMT1/hsa-miR-124-3p/BCAT1 pathway in regulating growth and invasion of esophageal squamous cell carcinoma

Bo Zeng, Xin Zhang, Jingling Zhao, Zhewei Wei, Haoshuai Zhu, Minyi Fu, Dawei Zou, Yanfen Feng, Honghe Luo, Yiyan Lei

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Artificial neural network models to predict nodal status in clinically node-negative breast cancer

Looket Dihge, Mattias Ohlsson, Patrik Edén, Pär-Ola Bendahl, Lisa Rydén

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Influence of patient and tumor characteristics on therapy persistence with letrozole in postmenopausal women with advanced breast cancer: results of the prospective observational EvAluate-TM study

Markus Wallwiener, Naiba Nabieva, Manuel Feisst, Tanja Fehm, Johann de Waal, Mahdi Rezai, Bernd Baier, Gerold Baake, Hans-Christian Kolberg, Martin Guggenberger, Mathias Warm, Nadia Harbeck, Rachel Wuerstlein, Jörg-Uwe Deuker, Peter Dall, Barbara Richter, Grischa Wachsmann, Cosima Brucker, Jan Willem Siebers, Milos Popovic, Thomas Kuhn, Christopher Wolf, Hans-Walter Vollert, Georg-Peter Breitbach, Wolfgang Janni, Robert Landthaler, Andreas Kohls, Daniela Rezek, Thomas Noesselt, Gunnar Fischer, Stephan Henschen, Thomas Praetz, Volker Heyl, Thorsten Kühn, Thomas Krauss, Christoph Thomssen, Andre Hohn, Hans Tesch, Christoph Mundhenke, Alexander Hein, Claudia Rauh, Christian M. Bayer, Katja Schmidt, Erik Belleville, Sara Y. Brucker, Peyman Hadji, Matthias W. Beckmann, Diethelm Wallwiener, Sherko Kümmel, Andreas Hartkopf, Peter A. Fasching

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study

Kerri Beckmann, Beth Russell, Debra Josephs, Hans Garmo, Christel Haggstrom, Lars Holmberg, Pär Stattin, Mieke Van Hemelrijck, Jan Adolfsson

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A germline mutation in Rab43 gene identified from a cancer family predisposes to a hereditary liver-colon cancer syndrome

Yanting Jiang, Yue Sun, Jiandong Hu, Nan Yu, Hui Liu, Jiankun Fan, Xuelian Ning, Yilan Li, Baogang Liu, Yihua Sun, Jinwei Zhang, Xiaohong Qiu, Songbin Fu, Chunshui Zhou, Hui Xu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

An improved method of delivering a sclerosing agent for the treatment of malignant pleural effusion

Tim N. Beck, Alexander Y. Deneka, Louis Chai, Colin Kanach, Priya Johal, Nicolas J. Alvarez, Yanis Boumber, Erica A. Golemis, Glenn W. Laub

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Verification of the effects of calcium channel blockers on the immune microenvironment of breast cancer

Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Achieving a timely diagnosis for teenagers and young adults with cancer: the ACE “too young to get cancer?” study

Rachel M. Dommett, Hannah Pring, Jamie Cargill, Paul Beynon, Alison Cameron, Rachel Cox, Aoife Nechowska, Alison Wint, Michael C. G. Stevens

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Long non-coding RNA HOXB-AS3 promotes myeloid cell proliferation and its higher expression is an adverse prognostic marker in patients with acute myeloid leukemia and myelodysplastic syndrome

Huai-Hsuan Huang, Fei-Yun Chen, Wen-Chien Chou, Hsin-An Hou, Bor-Sheng Ko, Chien-Ting Lin, Jih-Luh Tang, Chi-Cheng Li, Ming Yao, Woei Tsay, Szu-Chun Hsu, Shang-Ju Wu, Chien-Yuan Chen, Shang-Yi Huang, Mei-Hsuan Tseng, Hwei-Fang Tien, Ruey-Hwa Chen

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Inhibition of PI3K/Akt/mTOR signaling pathway alleviates ovarian cancer chemoresistance through reversing epithelial-mesenchymal transition and decreasing cancer stem cell marker expression

Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham, Yong Li

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Master regulator analysis of paragangliomas carrying SDHx, VHL, or MAML3 genetic alterations

John A. Smestad, L. James Maher III

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Relationship between tumor biomarkers and efficacy in MARIANNE, a phase III study of trastuzumab emtansine ± pertuzumab versus trastuzumab plus taxane in HER2-positive advanced breast cancer

Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre, Paul Anthony Ellis

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study

Naohiko Nakamura, Etsuro Hatano, Kohta Iguchi, Motohiko Sato, Hiroaki Kawaguchi, Iwao Ohtsu, Takaki Sakurai, Nobuhiro Aizawa, Hiroko Iijima, Shuhei Nishiguchi, Takuya Tomono, Yukihiro Okuda, Seidai Wada, Satoru Seo, Kojiro Taura, Shinji Uemoto, Masaya Ikegawa

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients

Chenxi Liu, Cheng Xiao, Jianjia Chen, Xiangyang Li, Zijian Feng, Qiyuan Gao, Zhen Liu

01.12.2019 | Study protocol | Ausgabe 1/2019 Open Access

First-line single-agent panitumumab in frail elderly patients with wild-type RAS unresectable colorectal cancer: a phase II study protocol OGSG 1602

Tetsuji Terazawa, Takeshi Kato, Masahiro Goto, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Yoshihiro Matsubara, Taroh Satoh

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma

Miia Ruuskanen, Ilmo Leivo, Heikki Minn, Tero Vahlberg, Caj Haglund, Jaana Hagström, Heikki Irjala

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Neoadjuvant docetaxel, cisplatin and ifosfamide (ITP) combination chemotherapy for treating penile squamous cell carcinoma patients with terminal lymph node metastasis

Jian Xu, Gang Li, Shi Miao Zhu, Qi Liang Cai, Zhun Wang, Xiong Yang, Hong Tan Zhang, Yuan Jie Niu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Determinants for non-sentinel node metastases in primary invasive breast cancer: a population-based cohort study of 602 consecutive patients with sentinel node metastases

Shabaz Majid, Lisa Rydén, Jonas Manjer

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo

Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio, Eugenio Zoni

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma

Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie J. Sandberg, Swapnil Potdar, Aija Kyttälä, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg, Einar O. Vik-Mo

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Serum chitinase activity prognosticates metastasis of colorectal cancer

Zhangfa Song, Engeng Chen, Jun Qian, Jianbin Xu, Gaoyang Cao, Wei Zhou, Fei Wang, Min Chen, Dengyong Xu, Xiaowei Wang, Xiaotong Hu, Zhenyu Ju, Xuefeng Huang, Xiujun Cai

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

TSPAN9 and EMILIN1 synergistically inhibit the migration and invasion of gastric cancer cells by increasing TSPAN9 expression

Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi, Wensheng Qiu

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Predictors of mammographic density among women with a strong family history of breast cancer

Olivia Moran, Andrea Eisen, Rochelle Demsky, Kristina Blackmore, Julia A. Knight, Seema Panchal, Ophira Ginsburg, Kevin Zbuk, Martin Yaffe, Kelly A. Metcalfe, Steven A. Narod, Joanne Kotsopoulos

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

A new pragmatic design for dose escalation in phase 1 clinical trials using an adaptive continual reassessment method

Bernard North, Hemant Mahendrakumar Kocher, Peter Sasieni

01.12.2019 | Research article | Ausgabe 1/2019 Open Access

Peripheral ganglia in healthy rats as target structures for the evaluation of PSMA imaging agents

Heike Endepols, Agnieszka Morgenroth, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Raphael Richarz, Sergio Muñoz Vásquez, Bernd Neumaier, Felix M. Mottaghy