Ausgabe 4/2018
Inhalt (15 Artikel)
Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach
Angela M. Krackhardt, Brigitte Anliker, Martin Hildebrandt, Michael Bachmann, Stefan B. Eichmüller, Dirk M. Nettelbeck, Matthias Renner, Lutz Uharek, Gerald Willimsky, Michael Schmitt, Winfried S. Wels, Martina Schüssler-Lenz
Human c-SRC kinase (CSK) overexpression makes T cells dummy
Else Marit Inderberg, Nadia Mensali, Morten P. Oksvold, Lars-Egil Fallang, Anne Fåne, Gjertrud Skorstad, Grethe-Elisabeth Stenvik, Cinzia Progida, Oddmund Bakke, Gunnar Kvalheim, June H. Myklebust, Sébastien Wälchli
IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients
Narmeen Ahmad, Aula Ammar, Sarah J. Storr, Andrew R. Green, Emad Rakha, Ian O. Ellis, Stewart G. Martin
Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+ TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy
Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Yu-Ching Lan, Ying-Shu You, An-Cheng Shiau, William Tzu-Liang Chen, K. S. Clifford Chao
Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report
Helen M. McGuire, Elena Shklovskaya, Jarem Edwards, Paul R. Trevillian, Geoffrey W. McCaughan, Patrick Bertolino, Catriona McKenzie, Ralph Gourlay, Stuart J. Gallagher, Barbara Fazekas de St. Groth, Peter Hersey
Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells
Tina Nham, Sophie M. Poznanski, Isabella Y. Fan, Mira M. Shenouda, Marianne V. Chew, Amanda J. Lee, Fatemeh Vahedi, Yalda Karimi, Martin Butcher, Dean A. Lee, Hal Hirte, Ali A. Ashkar
Reduction of myeloid-derived suppressor cells reinforces the anti-solid tumor effect of recipient leukocyte infusion in murine neuroblastoma-bearing allogeneic bone marrow chimeras
Isabelle Dierckx de Casterlé, Sabine Fevery, Omer Rutgeerts, Fariba Poosti, Sofie Struyf, Caroline Lenaerts, Mark Waer, An D. Billiau, Ben Sprangers
A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice
Joseph M. Ryan, Payal Mittal, Antoine Menoret, Julia Svedova, Jeffrey S. Wasser, Adam J. Adler, Anthony T. Vella
The role of interleukin-2, all-trans retinoic acid, and natural killer cells: surveillance mechanisms in anti-GD2 antibody therapy in neuroblastoma
Rosa Nguyen, Jim Houston, Wing K. Chan, David Finkelstein, Michael A. Dyer
Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model
Alex Allen, Chuan Wang, Lisa J. Caproni, Gessa Sugiyarto, Elena Harden, Leon R. Douglas, Patrick J. Duriez, Kinga Karbowniczek, Jon Extance, Paul J. Rothwell, Ifeayinwa Orefo, John P. Tite, Freda K. Stevenson, Christian H. Ottensmeier, Natalia Savelyeva
Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors
Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron E. Lukacher, Todd D. Schell
Abscopal effects of radiotherapy and combined mRNA-based immunotherapy in a syngeneic, OVA-expressing thymoma mouse model
Lucas Basler, Aleksandra Kowalczyk, Regina Heidenreich, Mariola Fotin-Mleczek, Savas Tsitsekidis, Daniel Zips, Franziska Eckert, Stephan M. Huber
Epstein–Barr virus strain heterogeneity impairs human T-cell immunity
Ana Cirac, Simon Stützle, Michael Dieckmeyer, Dinesh Adhikary, Andreas Moosmann, Nina Körber, Tanja Bauer, Klaus Witter, Henri-Jacques Delecluse, Uta Behrends, Josef Mautner
An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression
Rika Fujii, Caroline Jochems, Sarah R. Tritsch, Hing C. Wong, Jeffrey Schlom, James W. Hodge
N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner
Matthew J. Scheffel, Gina Scurti, Megan M. Wyatt, Elizabeth Garrett-Mayer, Chrystal M. Paulos, Michael I. Nishimura, Christina Voelkel-Johnson