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Cancer Immunology, Immunotherapy

Ausgabe 4/2018

Inhalt (15 Artikel)

Review

Clinical translation and regulatory aspects of CAR/TCR-based adoptive cell therapies—the German Cancer Consortium approach

Angela M. Krackhardt, Brigitte Anliker, Martin Hildebrandt, Michael Bachmann, Stefan B. Eichmüller, Dirk M. Nettelbeck, Matthias Renner, Lutz Uharek, Gerald Willimsky, Michael Schmitt, Winfried S. Wels, Martina Schüssler-Lenz

Original Article

Human c-SRC kinase (CSK) overexpression makes T cells dummy

Else Marit Inderberg, Nadia Mensali, Morten P. Oksvold, Lars-Egil Fallang, Anne Fåne, Gjertrud Skorstad, Grethe-Elisabeth Stenvik, Cinzia Progida, Oddmund Bakke, Gunnar Kvalheim, June H. Myklebust, Sébastien Wälchli

Open Access Original Article

IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients

Narmeen Ahmad, Aula Ammar, Sarah J. Storr, Andrew R. Green, Emad Rakha, Ian O. Ellis, Stewart G. Martin

Original Article

Cytosolic high-mobility group box protein 1 (HMGB1) and/or PD-1+ TILs in the tumor microenvironment may be contributing prognostic biomarkers for patients with locally advanced rectal cancer who have undergone neoadjuvant chemoradiotherapy

Chih-Yang Huang, Shu-Fen Chiang, Tao-Wei Ke, Tsung-Wei Chen, Yu-Ching Lan, Ying-Shu You, An-Cheng Shiau, William Tzu-Liang Chen, K. S. Clifford Chao

Open Access Original Article

Anti-PD-1-induced high-grade hepatitis associated with corticosteroid-resistant T cells: a case report

Helen M. McGuire, Elena Shklovskaya, Jarem Edwards, Paul R. Trevillian, Geoffrey W. McCaughan, Patrick Bertolino, Catriona McKenzie, Ralph Gourlay, Stuart J. Gallagher, Barbara Fazekas de St. Groth, Peter Hersey

Original Article

Ex vivo-expanded NK cells from blood and ascites of ovarian cancer patients are cytotoxic against autologous primary ovarian cancer cells

Tina Nham, Sophie M. Poznanski, Isabella Y. Fan, Mira M. Shenouda, Marianne V. Chew, Amanda J. Lee, Fatemeh Vahedi, Yalda Karimi, Martin Butcher, Dean A. Lee, Hal Hirte, Ali A. Ashkar

Original Article

Reduction of myeloid-derived suppressor cells reinforces the anti-solid tumor effect of recipient leukocyte infusion in murine neuroblastoma-bearing allogeneic bone marrow chimeras

Isabelle Dierckx de Casterlé, Sabine Fevery, Omer Rutgeerts, Fariba Poosti, Sofie Struyf, Caroline Lenaerts, Mark Waer, An D. Billiau, Ben Sprangers

Original Article

A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice

Joseph M. Ryan, Payal Mittal, Antoine Menoret, Julia Svedova, Jeffrey S. Wasser, Adam J. Adler, Anthony T. Vella

Open Access Original Article

Linear doggybone DNA vaccine induces similar immunological responses to conventional plasmid DNA independently of immune recognition by TLR9 in a pre-clinical model

Alex Allen, Chuan Wang, Lisa J. Caproni, Gessa Sugiyarto, Elena Harden, Leon R. Douglas, Patrick J. Duriez, Kinga Karbowniczek, Jon Extance, Paul J. Rothwell, Ifeayinwa Orefo, John P. Tite, Freda K. Stevenson, Christian H. Ottensmeier, Natalia Savelyeva

Original Article

Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumors

Lindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron E. Lukacher, Todd D. Schell

Original Article

Abscopal effects of radiotherapy and combined mRNA-based immunotherapy in a syngeneic, OVA-expressing thymoma mouse model

Lucas Basler, Aleksandra Kowalczyk, Regina Heidenreich, Mariola Fotin-Mleczek, Savas Tsitsekidis, Daniel Zips, Franziska Eckert, Stephan M. Huber

Original Article

Epstein–Barr virus strain heterogeneity impairs human T-cell immunity

Ana Cirac, Simon Stützle, Michael Dieckmeyer, Dinesh Adhikary, Andreas Moosmann, Nina Körber, Tanja Bauer, Klaus Witter, Henri-Jacques Delecluse, Uta Behrends, Josef Mautner

Original Article

An IL-15 superagonist/IL-15Rα fusion complex protects and rescues NK cell-cytotoxic function from TGF-β1-mediated immunosuppression

Rika Fujii, Caroline Jochems, Sarah R. Tritsch, Hing C. Wong, Jeffrey Schlom, James W. Hodge

Original Article

N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner

Matthew J. Scheffel, Gina Scurti, Megan M. Wyatt, Elizabeth Garrett-Mayer, Chrystal M. Paulos, Michael I. Nishimura, Christina Voelkel-Johnson

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