Ausgabe 9/2019
Inhalt (13 Artikel)
Anti-CAR-engineered T cells for epitope-based elimination of autologous CAR T cells
Stefanie Koristka, Pauline Ziller-Walter, Ralf Bergmann, Claudia Arndt, Anja Feldmann, Alexandra Kegler, Marc Cartellieri, Armin Ehninger, Gerhard Ehninger, Martin Bornhäuser, Michael P. Bachmann
Successful combination therapy of systemic checkpoint inhibitors and intralesional interleukin-2 in patients with metastatic melanoma with primary therapeutic resistance to checkpoint inhibitors alone
David Rafei-Shamsabadi, Saskia Lehr, Dagmar von Bubnoff, Frank Meiss
A VEGFR2–MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in mice
Yao Xu, Xinrong Zhang, Yong Wang, Mingzhu Pan, Min Wang, Juan Zhang
Morphomolecular analysis of the immune tumor microenvironment in human head and neck cancer
Mohamed Badr, Korinna Jöhrens, Michael Allgäuer, Melanie Boxberg, Wilko Weichert, Ingeborg Tinhofer, Carsten Denkert, Peter Schirmacher, Albrecht Stenzinger, Jan Budczies
Melanoma-conditioned medium promotes cytotoxic immune responses by murine bone marrow-derived monocytes despite their expression of ‘M2’ markers
Liam Friel Tremble, Anne C. Moore, Patrick F. Forde
Safety and efficacy of PD-1 blockade-activated multiple antigen-specific cellular therapy alone or in combination with apatinib in patients with advanced solid tumors: a pooled analysis of two prospective trials
Lijun Liang, Yixuan Wen, Rong Hu, Lei Wang, Youyou Xia, Chenxi Hu, Yun Qiao, Xiaowei Geng, Ting Chen, Jiayan Fei, Kaiyuan Hui, Xiaodong Jiang
An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation
Luciano Castiello, Alessandra Zevini, Elisabetta Vulpis, Michela Muscolini, Matteo Ferrari, Enrico Palermo, Giovanna Peruzzi, Christian Krapp, Martin Jakobsen, David Olagnier, Alessandra Zingoni, Angela Santoni, John Hiscott
TNFSF4 (OX40L) expression and survival in locally advanced and metastatic melanoma
Jason Roszik, Ettai Markovits, Paula Dobosz, Adi Layani, Keren Slabodnik-Kaner, Erez N. Baruch, Guy Ben-Betzalel, Elizabeth Grimm, Raanan Berger, Yehezkel Sidi, Jacob Schachter, Ronnie Shapira-Frommer, Dror Avni, Gal Markel, Raya Leibowitz-Amit
Tumor-induced peripheral immunosuppression promotes brain metastasis in patients with non-small cell lung cancer
Yuping D. Li, Jonathan B. Lamano, Jason B. Lamano, Jessica Quaggin-Smith, Dorina Veliceasa, Gurvinder Kaur, Dauren Biyashev, Dusten Unruh, Orin Bloch
Lymphocyte-specific kinase expression is a prognostic indicator in ovarian cancer and correlates with a prominent B cell transcriptional signature
Emily Hinchcliff, Cherie Paquette, Jason Roszik, Sarah Kelting, Mark H. Stoler, Samuel C. Mok, Tsz-Lun Yeung, Qian Zhang, Melinda Yates, Weiyi Peng, Patrick Hwu, Amir Jazaeri
Anti-PD-1 therapy combined with chemotherapy in patients with advanced biliary tract cancer
Danyang Sun, Junxun Ma, Jinliang Wang, Chun Han, Yuanyu Qian, Guangying Chen, Xiaoyan Li, Juan Zhang, Pengfei Cui, Wushuang Du, Zhaozhen Wu, Shixue Chen, Xuan Zheng, Zhichao Yue, Jia Song, Chan Gao, Xiaochen Zhao, Shangli Cai, Yi Hu
Independent expression of circulating and tissue levels of PD-L1: correlation of clusters with tumor metabolism and outcome in patients with non-small cell lung cancer
Fabio Grizzi, Angelo Castello, Dorina Qehajaj, Luca Toschi, Sabrina Rossi, Daniela Pistillo, Valentina Paleari, Giulia Veronesi, Pierluigi Novellis, Simona Monterisi, Rossana Mineri, Daoud Rahal, Egesta Lopci
A phase II study of the L19IL2 immunocytokine in combination with dacarbazine in advanced metastatic melanoma patients
Benjamin Weide, Thomas Eigentler, Chiara Catania, Paolo Antonio Ascierto, Stefano Cascinu, Jürgen C. Becker, Axel Hauschild, Antonella Romanini, Riccardo Danielli, Reinhard Dummer, Uwe Trefzer, Giuliano Elia, Dario Neri, Claus Garbe