Ausgabe 1/2017
Inhalt (317 Artikel)
Role of vasopressin and terlipressin in refractory shock compared to conventional therapy in the neonatal and pediatric population: a systematic review, meta-analysis, and trial sequential analysis
Reem Masarwa, Gideon Paret, Amichai Perlman, Shimon Reif, Bruria Hirsh Raccah, Ilan Matok
Is platelet transfusion associated with hospital-acquired infections in critically ill patients?
Cécile Aubron, Andrew W. Flint, Michael Bailey, David Pilcher, Allen C. Cheng, Colin Hegarty, Antony Martinelli, Michael C. Reade, Rinaldo Bellomo, Zoe McQuilten
Effect of perioperative sodium bicarbonate administration on renal function following cardiac surgery for infective endocarditis: a randomized, placebo-controlled trial
Jin Sun Cho, Sarah Soh, Jae-Kwang Shim, Sanghwa Kang, Haegi Choi, Young-Lan Kwak
Use of noninvasive ventilation in immunocompromised patients with acute respiratory failure: a systematic review and meta-analysis
Hui-Bin Huang, Biao Xu, Guang-Yun Liu, Jian-Dong Lin, Bin Du
Normal saline versus heparin for patency of central venous catheters in adult patients - a systematic review and meta-analysis
Lei Zhong, Hai-Li Wang, Bo Xu, Yao Yuan, Xin Wang, Ying-ying Zhang, Li Ji, Zi-mu Pan, Zhan-Sheng Hu
Communicating with conscious mechanically ventilated critically ill patients: let them speak with deflated cuff and an in-line speaking valve!
Peter H. Egbers, E. Christiaan Boerma
Should we assume that hypothermia is a dysfunction in sepsis?
Alexandre A. Steiner, Monique T. Fonseca, Francisco G. Soriano
Whole-body vibration to prevent intensive care unit-acquired weakness: safety, feasibility, and metabolic response
Tobias Wollersheim, Kurt Haas, Stefan Wolf, Knut Mai, Claudia Spies, Elisabeth Steinhagen-Thiessen, Klaus-D. Wernecke, Joachim Spranger, Steffen Weber-Carstens
Promoting early identification of sepsis in hospitalized patients with nurse-led protocols
Ruth Kleinpell
Does training improve diagnostic accuracy and inter-rater agreement in applying the Berlin radiographic definition of acute respiratory distress syndrome? A multicenter prospective study
Jin-Min Peng, Chuan-Yun Qian, Xiang-You Yu, Ming-Yan Zhao, Shu-Sheng Li, Xiao-Chun Ma, Yan Kang, Fa-Chun Zhou, Zhen-Yang He, Tie-He Qin, Yong-Jie Yin, Li Jiang, Zhen-Jie Hu, Ren-Hua Sun, Jian-Dong Lin, Tong Li, Da-Wei Wu, You-Zhong An, Yu-Hang Ai, Li-Hua Zhou, Xiang-Yuan Cao, Xi-Jing Zhang, Rong-Qing Sun, Er-Zhen Chen, Bin Du
Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?
Taku Oshima, Séverine Graf, Claudia-Paula Heidegger, Laurence Genton, Jérôme Pugin, Claude Pichard
The role of total cell-free DNA in predicting outcomes among trauma patients in the intensive care unit: a systematic review
Mikail Gögenur, Jakob Burcharth, Ismail Gögenur
The association of findings on brain computed tomography with neurologic outcomes following extracorporeal cardiopulmonary resuscitation
Jeong-Am Ryu, Chi Ryang Chung, Yang Hyun Cho, Kiick Sung, Gee Young Suh, Taek Kyu Park, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Hyeon-Cheol Gwon, Seung-Hyuk Choi, Jeong Hoon Yang
Erratum to: Volume and its relationship to cardiac output and venous return
S. Magder
Optimal doses of caspofungin during continuous venovenous hemodiafiltration in critically ill patients
Gerardo Aguilar, Rafael Ferriols, Angels Lozano, Carlos Ezquer, José A. Carbonell, Ana Jurado, Juan Carrizo, Ferran Serralta, Jaume Puig, David Navarro, Manuel Alos, F. Javier Belda
Immunotherapy improves the prognosis of lung cancer: do we have to change intensive care unit admission and triage guidelines?
Antoine Guillon, Karen L. Reckamp, Nathalie Heuzé-Vourc’h
Viral and bacterial co-infection in pneumonia: do we know enough to improve clinical care?
Kelly A. Cawcutt, Andre C. Kalil
Predicting critical illness mortality and personalizing therapy: moving to multi-dimensional data
Zudin A. Puthucheary, Paul Wischmeyer
A diaphragmatic electrical activity-based optimization strategy during pressure support ventilation improves synchronization but does not impact work of breathing
Francois Beloncle, Lise Piquilloud, Nuttapol Rittayamai, Christer Sinderby, Hadrien Rozé, Laurent Brochard
A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients
Jordi Rello, Claus-Georg Krenn, Gottfried Locker, Ernst Pilger, Christian Madl, Laura Balica, Thierry Dugernier, Pierre-Francois Laterre, Herbert Spapen, Pieter Depuydt, Jean-Louis Vincent, Lajos Bogár, Zsuzsanna Szabó, Barbara Völgyes, Rafael Máñez, Nahit Cakar, Atilla Ramazanoglu, Arzu Topeli, Maria A. Mastruzzo, Abel Jasovich, Christian G. Remolif, Liliana del Carmen Soria, Max A. Andresen Hernandez, Carolina Ruiz Balart, Ildikó Krémer, Zsolt Molnár, Frank von Sonnenburg, Arthur Lyons, Michael Joannidis, Heinz Burgmann, Tobias Welte, Anton Klingler, Romana Hochreiter, Kerstin Westritschnig
The effects of low tidal ventilation on lung strain correlate with respiratory system compliance
Jianfeng Xie, Fang Jin, Chun Pan, Songqiao Liu, Ling Liu, Jingyuan Xu, Yi Yang, Haibo Qiu
Skin autofluorescence in acute kidney injury
Aurelie Lavielle, Sebastien Rubin, Alexandre Boyer, Karine Moreau, Kalina Rajaobelina, Christian Combe, Vincent Rigalleau
Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism
PärIngemar Johansson, Jakob Stensballe, SisseRye Ostrowski
Could type 2 diabetes be a component of the post-intensive care syndrome?
Jean-Charles Preiser, Caroline de Longueville
Freedom of speech for all critically ill patients: work in progress
P. R. Tuinman, S. ten Hoorn
Blood pressure and acute kidney injury
Ryota Sato, Sarah Kyuragi Luthe, Michitaka Nasu
The importance of diastolic dysfunction in the development of weaning-induced pulmonary oedema
Filippo Sanfilippo, Cristina Santonocito, Gaetano Burgio, Antonio Arcadipane
A response to “Response to a Trial on Reversal of Death by Neurologic Criteria”
Ira S. Pastor
The success of pre-hospital tracheal intubation by different pre-hospital providers: a systematic literature review and meta-analysis
K. Crewdson, D. J. Lockey, J. Røislien, H. M. Lossius, M. Rehn
Point-of-care testing for emergency assessment of coagulation in patients treated with direct oral anticoagulants
Matthias Ebner, Ingvild Birschmann, Andreas Peter, Charlotte Spencer, Florian Härtig, Joachim Kuhn, Gunnar Blumenstock, Christine S. Zuern, Ulf Ziemann, Sven Poli
Use of stepwise lactate kinetics-oriented hemodynamic therapy could improve the clinical outcomes of patients with sepsis-associated hyperlactatemia
Xiang Zhou, Dawei Liu, Longxiang Su, Bo Yao, Yun Long, Xiaoting Wang, Wenzhao Chai, Na Cui, Hao Wang, Xi Rui
The impact of post-operative sepsis on mortality after hospital discharge among elective surgical patients: a population-based cohort study
Lixin Ou, Jack Chen, Ken Hillman, Arthas Flabouris, Michael Parr, Hassan Assareh, Rinaldo Bellomo
Noninvasive detection of alarming intracranial pressure changes by auditory monitoring in early management of brain injury: a prospective invasive versus noninvasive study
Fabrice Giraudet, François Longeras, Aurélien Mulliez, Aurélie Thalamy, Bruno Pereira, Paul Avan, Laurent Sakka
Can body mass index predict clinical outcomes for patients with acute lung injury/acute respiratory distress syndrome? A meta-analysis
Yue-Nan Ni, Jian Luo, He Yu, Yi-Wei Wang, Yue-Hong Hu, Dan Liu, Bin-Miao Liang, Zong-An Liang
Catecholamines as outcome markers in isolated traumatic brain injury: the COMA-TBI study
Sandro B. Rizoli, Blessing N. R. Jaja, Alex P. Di Battista, Shawn G. Rhind, Antonio Capone Neto, Leodante da Costa, Kenji Inaba, Luis Teodoro da Luz, Bartolomeu Nascimento, Adic Perez, Andrew J. Baker, Airton Leonardo de Oliveira Manoel
SOFA and mortality endpoints in randomized controlled trials: a systematic review and meta-regression analysis
Harm-Jan de Grooth, Irma L. Geenen, Armand R. Girbes, Jean-Louis Vincent, Jean-Jacques Parienti, Heleen M. Oudemans-van Straaten
Optimal energy delivery and measured energy expenditure—impact of length of stay
Mette M. Berger, Claude Pichard, Eric Fontaine
Erratum to: Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside
Antoine Kimmoun, Emmanuel Novy, Thomas Auchet, Nicolas Ducrocq, Bruno Levy
Erratum to: Resuscitative endovascular balloon occlusion of the aorta versus aortic cross clamping among patients with critical trauma: a nationwide cohort study in Japan
Toshikazu Abe, Masatoshi Uchida, Isao Nagata, Daizoh Saitoh, Nanako Tamiya
Erratum to: Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis
William Manzanares, Paul E. Wischmeyer
Response to “Reassessing the death risk related to probiotics in critically ill patients”
William Manzanares, Paul E. Wischmeyer
The accuracy of transcranial Doppler in excluding intracranial hypertension following acute brain injury: a multicenter prospective pilot study
Frank A. Rasulo, Rita Bertuetti, Chiara Robba, Francesco Lusenti, Alfredo Cantoni, Marta Bernini, Alan Girardini, Stefano Calza, Simone Piva, Nazzareno Fagoni, Nicola Latronico
Duration of veno-arterial extracorporeal life support (VA ECMO) and outcome: an analysis of the Extracorporeal Life Support Organization (ELSO) registry
Myles Smith, Alexander Vukomanovic, Daniel Brodie, Ravi Thiagarajan, Peter Rycus, Hergen Buscher
Evaluation of clinically available renal biomarkers in critically ill adults: a prospective multicenter observational study
Yujun Deng, Ruibin Chi, Shenglong Chen, Heng Ye, Jie Yuan, Lin Wang, Yiling Zhai, Lu Gao, Danqing Zhang, Linhui Hu, Bo Lv, Yi Long, Cheng Sun, Xiaobing Yang, Xia Zou, Chunbo Chen
Genetic variants in SERPINA4 and SERPINA5, but not BCL2 and SIK3 are associated with acute kidney injury in critically ill patients with septic shock
Laura M. Vilander, Mari A. Kaunisto, Suvi T. Vaara, Ville Pettilä, Raili Laru-Sompa, Anni Pulkkinen, Minna Saarelainen, Mikko Reilama, Sinikka Tolmunen, Ulla Rantalainen, Marja Miettinen, Markku Suvela, Katrine Pesola, Pekka Saastamoinen, Sirpa Kauppinen, Ville Pettilä, Kirsi-Maija Kaukonen, Anna-Maija Korhonen, Sara Nisula, Suvi Vaara, Raili Suojaranta-Ylinen, Leena Mildh, Mikko Haapio, Laura Nurminen, Sari Sutinen, Leena Pettilä, Helinä Laitinen, Heidi Syrjä, Kirsi Henttonen, Elina Lappi, Hillevi Boman, Tero Varpula, Päivi Porkka, Mirka Sivula, Mira Rahkonen, Anne Tsurkka, Taina Nieminen, Niina Prittinen, Ari Alaspää, Ville Salanto, Hanna Juntunen, Teija Sanisalo, Ilkka Parviainen, Ari Uusaro, Esko Ruokonen, Stepani Bendel, Niina Rissanen, Maarit Lång, Sari Rahikainen, Saija Rissanen, Merja Ahonen, Elina Halonen, Eija Vaskelainen, Meri Poukkanen, Esa Lintula, Sirpa Suominen, Jorma Heikkinen, Timo Lavander, Kirsi Heinonen, Anne-Mari Juopperi, Tadeusz Kaminski, Fiia Gäddnäs, Tuija Kuusela, Jane Roiko, Sari Karlsson, Matti Reinikainen, Tero Surakka, Helena Jyrkönen, Tanja Eiserbeck, Jaana Kallinen, Vesa Lund, Päivi Tuominen, Pauliina Perkola, Riikka Tuominen, Marika Hietaranta, Satu Johansson, Seppo Hovilehto, Anne Kirsi, Pekka Tiainen, Tuija Myllärinen, Pirjo Leino, Anne Toropainen, Anne Kuitunen, Ilona Leppänen, Markus Levoranta, Sanna Hoppu, Jukka Sauranen, Jyrki Tenhunen, Atte Kukkurainen, Samuli Kortelainen, Simo Varila, Outi Inkinen, Niina Koivuviita, Jutta Kotamäki, Anu Laine, Tero Ala-Kokko, Jouko Laurila, Sinikka Sälkiö, Simo-Pekka Koivisto, Raku Hautamäki, Maria Skinnar
Decreased cytokine production by mononuclear cells after severe gram-negative infections: early clinical signs and association with final outcome
Nikolaos Antonakos, Thomas Tsaganos, Volker Oberle, Iraklis Tsangaris, Malvina Lada, Aikaterini Pistiki, Nikolaos Machairas, Maria Souli, Michael Bauer, Evangelos J. Giamarellos-Bourboulis
Blood components are essential to regulate microcirculatory blood flow
Nicolas Morel, Marie Moisan
Erratum to: Cardiac dysfunction induced by weaning from mechanical ventilation: incidence, risk factors, and effects of fluid removal
Jinglun Liu, Feng Shen, Jean-Louis Teboul, Nadia Anguel, Alexandra Beurton, Nadia Bezaz, Christian Richard, Xavier Monnet
Dual inhibition of thrombin and activated factor X attenuates disseminated intravascular coagulation and protects organ function in a baboon model of severe Gram-negative sepsis
Herbert Schöchl, Martijn van Griensven, Stefan Heitmeier, Volker Laux, Ulrike Kipman, Jan Roodt, Soheyl Bahrami, Heinz Redl
Effect of an automated notification system for deteriorating ward patients on clinical outcomes
Christian P. Subbe, Bernd Duller, Rinaldo Bellomo
Assessing preoperative plasma growth-differentiation factor-15 for prediction of acute kidney injury in patients undergoing cardiac surgery
Wei Zhang, Hai Chen Chu, Feng Xue
Point-of-care ultrasonography and liberation from mechanical ventilation
Gentle Sunder Shrestha
What is the risk of acquiring bacteria from prior intensive care unit bed occupants?
Vincenzo Russotto, Andrea Cortegiani, Santi Maurizio Raineri, Pasquale Iozzo, Cesare Gregoretti, Antonino Giarratano
Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation
Takashi Tagami, Hideo Yasunaga, Hiroyuki Yokota
Use of ‘tidal volume challenge’ to improve the reliability of pulse pressure variation
Sheila Nainan Myatra, Xavier Monnet, Jean-Louis Teboul
Anemia and blood transfusion in the critically ill patient with cardiovascular disease
Annemarie B. Docherty, Timothy S. Walsh
High-flow nasal cannula support therapy: new insights and improving performance
Gonzalo Hernández, Oriol Roca, Laura Colinas
Mechanical ventilation in obese ICU patients: from intubation to extubation
Audrey De Jong, Gerald Chanques, Samir Jaber
Novel insights in ICU-acquired respiratory muscle dysfunction: implications for clinical care
Annemijn H. Jonkman, Diana Jansen, Leo M. A. Heunks
Neuroanatomy of sepsis-associated encephalopathy
Nicholas Heming, Aurelien Mazeraud, Franck Verdonk, Fernando A. Bozza, Fabrice Chrétien, Tarek Sharshar
Medicating patients during extracorporeal membrane oxygenation: the evidence is building
Amy L. Dzierba, Darryl Abrams, Daniel Brodie
Anti-inflammatory properties of anesthetic agents
Fernanda Ferreira Cruz, Patricia Rieken Macedo Rocco, Paolo Pelosi
Facing the ongoing challenge of the febrile young infant
Adrienne G. DePorre, Paul L. Aronson, Russell J. McCulloh
The association of time and medications with changes in bone mineral density in the 2 years after critical illness
Neil R. Orford, Michael Bailey, Rinaldo Bellomo, Julie A. Pasco, Claire Cattigan, Tania Elderkin, Sharon L. Brennan-Olsen, David J. Cooper, Mark A. Kotowicz
Intestinal T lymphocyte homing is associated with gastric emptying and epithelial barrier function in critically ill: a prospective observational study
Christian Greis, Zohal Rasuly, Rolf A. Janosi, Lambros Kordelas, Dietrich W. Beelen, Tobias Liebregts
Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study
Anne-Mari Kantanen, Reetta Kälviäinen, Ilkka Parviainen, Marika Ala-Peijari, Tom Bäcklund, Juha Koskenkari, Ruut Laitio, Matti Reinikainen
Time-dependent association of glucocorticoids with adverse outcome in community-acquired pneumonia: a 6-year prospective cohort study
Manuela Nickler, Manuel Ottiger, Christian Steuer, Alexander Kutz, Mirjam Christ-Crain, Werner Zimmerli, Robert Thomann, Claus Hoess, Christoph Henzen, Luca Bernasconi, Andreas Huber, Beat Mueller, Philipp Schuetz, Ursula Schild, Katharina Regez, Rita Bossart, Robert Thomann, Claudine Falconnier, Marcel Wolbers, Stefanie Neidert, Thomas Fricker, Claudine Blum, Thomas Bregenzer, Claus Hoess, Heiner C. Bucher, Fabian Mueller, Jeannine Haeuptle, Roya Zarbosky, Rico Fiumefreddo, Melanie Wieland, Charly Nusbaumer, Andres Christ, Roland Bingisser, Kristian Schneider, Brigitte Walz, Verena Briner, Dieter Conen, Andreas Huber, Jody Staehelin, Chantal Bruehlhardt, Ruth Luginbuehl, Agnes Muehlemann, Ineke Lambinon, Werner Zimmerli, Max Zueger
Comparison of qSOFA and SIRS for predicting adverse outcomes of patients with suspicion of sepsis outside the intensive care unit
Eli J. Finkelsztein, Daniel S. Jones, Kevin C. Ma, Maria A. Pabón, Tatiana Delgado, Kiichi Nakahira, John E. Arbo, David A. Berlin, Edward J. Schenck, Augustine M. K. Choi, Ilias I. Siempos
Hemoadsorption by CytoSorb in septic patients: a case series
Klaus Kogelmann, Dominik Jarczak, Morten Scheller, Matthias Drüner
Clonidine for sedation in the critically ill: a systematic review and meta-analysis
Jing Gennie Wang, Emilie Belley-Coté, Lisa Burry, Mark Duffett, Timothy Karachi, Dan Perri, Waleed Alhazzani, Frederick D’Aragon, Hannah Wunsch, Bram Rochwerg
Life-threatening massive pulmonary embolism rescued by venoarterial-extracorporeal membrane oxygenation
Fillipo Corsi, Guillaume Lebreton, Nicolas Bréchot, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Charles-Edouard Luyt, Pascal Leprince, Jean Chastre, Alain Combes, Matthieu Schmidt
Diagnostic value of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein 7 for acute kidney injury: a meta-analysis
Hui-Miao Jia, Li-Feng Huang, Yue Zheng, Wen-Xiong Li
Corticosteroids in septic shock: a systematic review and network meta-analysis
Ben Gibbison, José A. López-López, Julian P. T. Higgins, Tom Miller, Gianni D. Angelini, Stafford L. Lightman, Djillali Annane
A path to precision in the ICU
David M. Maslove, Francois Lamontagne, John C. Marshall, Daren K. Heyland
Anatomic changes after repair of traumatic bilateral diaphragmatic rupture impede bi-caval dual lumen catheter insertion for veno-venous extracorporeal membrane oxygenation treatment
Alexa Hollinger, Daniel Tuchscherer, Jens Bremerich, Martin Siegemund
Lice, rodents, and many hopes: a rare disease in a young refugee
Salvatore L. Cutuli, Gennaro De Pascale, Teresa Spanu, Antonio M. Dell’Anna, Maria G. Bocci, Federico Pallavicini, Fabiola Mancini, Alessandra Ciervo, Massimo Antonelli
VCO2-derived energy expenditure: do not throw the baby out with the bath water!
Sandra N. Stapel, Paul W. G. Elbers, Heleen M. Oudemans-van Straaten
Inhaled nitric oxide and acute kidney injury: new insights from observational data
Laveena Munshi, Neill K. J. Adhikari
Implementing a bedside assessment of respiratory mechanics in patients with acute respiratory distress syndrome
Lu Chen, Guang-Qiang Chen, Kevin Shore, Orest Shklar, Concetta Martins, Brian Devenyi, Paul Lindsay, Heather McPhail, Ashley Lanys, Ibrahim Soliman, Mazin Tuma, Michael Kim, Kerri Porretta, Pamela Greco, Hilary Every, Chris Hayes, Andrew Baker, Jan O. Friedrich, Laurent Brochard
Determinants of the calibration of SAPS II and SAPS 3 mortality scores in intensive care: a European multicenter study
Antoine Poncet, Thomas V. Perneger, Paolo Merlani, Maurizia Capuzzo, Christophe Combescure
Retinal arterial blood flow and retinal changes in patients with sepsis: preliminary study using fluorescein angiography
Kristo Erikson, Janne Henrik Liisanantti, Nina Hautala, Juha Koskenkari, Remi Kamakura, Karl Heinz Herzig, Hannu Syrjälä, Tero Ilmari Ala-Kokko
Renal function and oxygenation are impaired early after liver transplantation despite hyperdynamic systemic circulation
Jenny Skytte Larsson, Gudrun Bragadottir, Bengt Redfors, Sven-Erik Ricksten
Cardiac biomarkers are associated with maximum stage of acute kidney injury in critically ill patients: a prospective analysis
Ryan Haines, Siobhan Crichton, Jessica Wilson, David Treacher, Marlies Ostermann
New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management
Frank Kroschinsky, Friedrich Stölzel, Simone von Bonin, Gernot Beutel, Matthias Kochanek, Michael Kiehl, Peter Schellongowski
Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a “two-hit” model
Mypinder S. Sekhon, Philip N. Ainslie, Donald E. Griesdale
Feasibility and safety of whole-body vibration therapy in intensive care patients
Peter Alter, Tobias Boeselt, Christoph Nell, Marc Spielmanns, Klaus Kenn, A. Rembert Koczulla
The future of critical care: renal support in 2027
William R. Clark, Mauro Neri, Francesco Garzotto, Zaccaria Ricci, Stuart L. Goldstein, Xiaoqiang Ding, Jiarui Xu, Claudio Ronco
Erratum to: Pre-hospital management of mass casualty civilian shootings: a systematic literature review
Conor D. A. Turner, David J. Lockey, Marius Rehn
Erratum to: Can calculation of energy expenditure based on CO2 measurements replace indirect calorimetry?
Taku Oshima, Séverine Graf, Claudia-Paula Heidegger, Laurence Genton, Jérôme Pugin, Claude Pichard
Early predictors of poor outcome after out-of-hospital cardiac arrest
Louise Martinell, Niklas Nielsen, Johan Herlitz, Thomas Karlsson, Janneke Horn, Matt P. Wise, Johan Undén, Christian Rylander
Plasma metabolomics for the diagnosis and prognosis of H1N1 influenza pneumonia
Mohammad M. Banoei, Hans J. Vogel, Aalim M. Weljie, Anand Kumar, Sachin Yende, Derek C. Angus, Brent W. Winston
Erratum to: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine
Sangeeta Mehta, John Granton, Anthony C. Gordon, Deborah J. Cook, Stephen Lapinsky, Gary Newton, Kris Bandayrel, Anjuli Little, Chuin Siau, Dieter Ayers, Joel Singer, Terry C. K. Lee, Keith R. Walley, Michelle Storms, D. James Cooper, Cheryl L. Holmes, Paul Hebert, Jeffrey Presneill, James A. Russell
A brief comment on vaccinations for opportunistic microorganisms
Ferhat Arslan, Haluk Vahaboğlu
Blood pressure deficits in acute kidney injury: not all about the mean arterial pressure?
Lui G. Forni, Michael Joannidis
Myocardial and haemodynamic responses to two fluid regimens in African children with severe malnutrition and hypovolaemic shock (AFRIM study)
Nchafatso Obonyo, Bernadette Brent, Peter Olupot-Olupot, Michael Boele van Hensbroek, Irene Kuipers, Sidney Wong, Kenji Shiino, Jonathan Chan, John Fraser, Job B. M. van Woensel, Kathryn Maitland
Association between fluid intake and mortality in critically ill patients with negative fluid balance: a retrospective cohort study
Yanfei Shen, Xinmei Huang, Weimin Zhang
Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis
Thiago Domingos Corrêa, Adriano José Pereira, Sebastian Brandt, Madhusudanarao Vuda, Siamak Djafarzadeh, Jukka Takala, Stephan Mathias Jakob
High protein intake without concerns?
Olav Rooyackers, Martin Sundström Rehal, Felix Liebau, Åke Norberg, Jan Wernerman
Erratum to: Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions
Cristóbal León, Sergio Ruiz-Santana, Pedro Saavedra, Carmen Castro, Ana Loza, Ismail Zakariya, Alejandro Úbeda, Manuel Parra, Desirée Macías, José Ignacio Tomás, Antonio Rezusta, Alejandro Rodríguez, Frederic Gómez, Estrella Martín-Mazuelos
Simvastatin for patients with acute respiratory distress syndrome: long-term outcomes and cost-effectiveness from a randomised controlled trial
A. Agus, C. Hulme, R. M. Verghis, C. McDowell, C. Jackson, C. M. O’Kane, J. G. Laffey, D. F. McAuley
Cost analysis of the very elderly admitted to intensive care units
Nicolas Chin-Yee, Gianni D’Egidio, Kednapa Thavorn, Daren Heyland, Kwadwo Kyeremanteng
Pre-admission functional status impacts the performance of the APACHE IV model of mortality prediction in critically ill patients
James S. Krinsley, Thomas Wasser, Gina Kang, Sean M. Bagshaw
Early EEG for outcome prediction of postanoxic coma: prospective cohort study with cost-minimization analysis
Lotte Sondag, Barry J. Ruijter, Marleen C. Tjepkema-Cloostermans, Albertus Beishuizen, Frank H. Bosch, Janine A. van Til, Michel J. A. M. van Putten, Jeannette Hofmeijer
Video vs direct laryngoscopy in the ICU: are we asking the right question?
Michael Chaim Sklar, Stephen Lapinsky
Comparison of fluid balance and hemodynamic and metabolic effects of sodium lactate versus sodium bicarbonate versus 0.9% NaCl in porcine endotoxic shock: a randomized, open-label, controlled study
Thibault Duburcq, Arthur Durand, Anne-Frédérique Dessein, Joseph Vamecq, Jean-Claude Vienne, Dries Dobbelaere, Karine Mention, Claire Douillard, Patrice Maboudou, Valery Gmyr, François Pattou, Mercé Jourdain, Fabienne Tamion, Julien Poissy, Daniel Mathieu, Raphaël Favory
Obesity and survival in critically ill patients with acute respiratory distress syndrome: a paradox within the paradox
Lorenzo Ball, Ary Serpa Neto, Paolo Pelosi
Echocardiography accurately predicts pulmonary hypertension in patients with advanced lung disease
Silvia Cottini, Christian Benden, Lars C. Huber, Mattia Arrigo
Diaphragm electrical activity monitoring as a breakpoint in the management of a tetraplegic child
Guillaume Mortamet, François Proulx, Benjamin Crulli, Nadia Savy, Philippe Jouvet, Guillaume Emeriaud
No-touch methods of terminal cleaning in the intensive care unit: results from the first large randomized trial with patient-centred outcomes
Vincenzo Russotto, Andrea Cortegiani, Pasquale Iozzo, Santi Maurizio Raineri, Cesare Gregoretti, Antonino Giarratano
Efficient organisation of intensive care units with a focus on quality: the non-physician provider
Herman Gerhard Kreeftenberg, Sjaak Pouwels, Peter Henricus Johannes van der Voort
Timing of appropriate empirical antimicrobial administration and outcome of adults with community-onset bacteremia
Ching-Chi Lee, Chung-Hsun Lee, Ming-Yuan Hong, Hung-Jen Tang, Wen-Chien Ko
Circulating microparticle levels are reduced in patients with ARDS
Ciara M. Shaver, Justin Woods, Jennifer K. Clune, Brandon S. Grove, Nancy E. Wickersham, J. Brennan McNeil, Gregory Shemancik, Lorraine B. Ware, Julie A. Bastarache
A critical age: can we reliably measure frailty in critical care?
Richard J. Pugh, Chris M. Thorpe, Christian P. Subbe
Outcome of acute respiratory distress syndrome in university and non-university hospitals in Germany
Konstantinos Raymondos, Tamme Dirks, Michael Quintel, Ulrich Molitoris, Jörg Ahrens, Thorben Dieck, Kai Johanning, Dietrich Henzler, Rolf Rossaint, Christian Putensen, Hermann Wrigge, Ralph Wittich, Maximilian Ragaller, Thomas Bein, Martin Beiderlinden, Maxi Sanmann, Christian Rabe, Jörn Schlechtweg, Monika Holler, Fernando Frutos-Vivar, Andres Esteban, Hartmut Hecker, Simone Rosseau, Vera von Dossow, Claudia Spies, Tobias Welte, Siegfried Piepenbrock, Steffen Weber-Carstens
Heat and moisture exchangers (HMEs) and heated humidifiers (HHs) in adult critically ill patients: a systematic review, meta-analysis and meta-regression of randomized controlled trials
Maria Vargas, Davide Chiumello, Yuda Sutherasan, Lorenzo Ball, Antonio M. Esquinas, Paolo Pelosi, Giuseppe Servillo
Critical care at the end of life: a population-level cohort study of cost and outcomes
Dipayan Chaudhuri, Peter Tanuseputro, Brent Herritt, Gianni D’Egidio, Mathieu Chalifoux, Kwadwo Kyeremanteng
How could we enhance translation of sepsis immunology to inform immunomodulation trials in sepsis?
M. Shankar-Hari
Effects of neurally adjusted ventilatory assist on air distribution and dead space in patients with acute exacerbation of chronic obstructive pulmonary disease
Qin Sun, Ling Liu, Chun Pan, Zhanqi Zhao, Jingyuan Xu, Airan Liu, Haibo Qiu
Trials directly comparing alternative spontaneous breathing trial techniques: a systematic review and meta-analysis
Karen E. A. Burns, Ibrahim Soliman, Neill K. J. Adhikari, Amer Zwein, Jessica T. Y. Wong, Carolina Gomez-Builes, Jose Augusto Pellegrini, Lu Chen, Nuttapol Rittayamai, Michael Sklar, Laurent J. Brochard, Jan O. Friedrich
Resting energy expenditure and optimal nutrition in critical care: how to guide our calorie prescriptions
Oren Zusman, Pierre Singer
Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury—a case report
Serge Jennes, Maia Merabishvili, Patrick Soentjens, Kim Win Pang, Thomas Rose, Elkana Keersebilck, Olivier Soete, Pierre-Michel François, Simona Teodorescu, Gunther Verween, Gilbert Verbeken, Daniel De Vos, Jean-Paul Pirnay
Daily cost of delay to adequate antibiotic treatment among patients surviving a hospitalization with community-onset Acinetobacter baumannii pneumonia or sepsis
Marya D. Zilberberg, Brian H. Nathanson, Kate Sulham, Weihong Fan, Andrew F. Shorr
Role of nutrition support in adult cardiac surgery: a consensus statement from an International Multidisciplinary Expert Group on Nutrition in Cardiac Surgery
Christian Stoppe, Andreas Goetzenich, Glenn Whitman, Rika Ohkuma, Trish Brown, Roupen Hatzakorzian, Arnold Kristof, Patrick Meybohm, Jefferey Mechanick, Adam Evans, Daniel Yeh, Bernard McDonald, Michael Chourdakis, Philip Jones, Richard Barton, Ravi Tripathi, Gunnar Elke, Oliver Liakopoulos, Ravi Agarwala, Vladimir Lomivorotov, Ekaterina Nesterova, Gernot Marx, Carina Benstoem, Margot Lemieux, Daren K. Heyland
Effect sizes in ongoing randomized controlled critical care trials
Elliott E. Ridgeon, Rinaldo Bellomo, Scott K. Aberegg, Rob Mac Sweeney, Rachel S. Varughese, Giovanni Landoni, Paul J. Young
Fourth Surviving Sepsis Campaign’s hemodynamic recommendations: a step forward or a return to chaos?
Glenn Hernández, Jean-Louis Teboul
Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study
Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma, Hiroyasu Ishikura, Shinjiro Saito, Shigehiko Uchino, Daisuke Kudo, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Hayakawa Katsura, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda, Yoshihiko Nakamura, Ryosuke Sekine, Kazuma Yamakawa, Yoshiaki Yoshikawa, Motohiro Sekino, Keiko Ueno, Yuko Okuda, Masayuki Watanabe, Akihito Tampo, Nobuyuki Saito, Yuya Kitai, Kohei Takimoto, Hiroki Takahashi, Iwao Kobayashi, Yutaka Kondo, Masamitsu Sanui, Yusuke Iizuka, Wataru Matsunaga, Sho Nachi, Toru Miike, Hiroshi Takahashi, Shuhei Takauji, Kensuke Umakoshi, Takafumi Todaka, Hiroshi Kodaira, Kohkichi Andoh, Takehiko Kasai, Yoshiaki Iwashita, Hideaki Arai, Masato Murata, Masahiro Yamane, Kazuhiro Shiga, Naoto Hori
The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: a retrospective propensity matched cohort study
Makoto Takaki, Kazuya Ichikado, Kodai Kawamura, Yasuhiro Gushima, Moritaka Suga
Transthoracic echocardiography: an accurate and precise method for estimating cardiac output in the critically ill patient
Pablo Mercado, Julien Maizel, Christophe Beyls, Dimitri Titeca-Beauport, Magalie Joris, Loay Kontar, Antoine Riviere, Olivier Bonef, Thierry Soupison, Christophe Tribouilloy, Bertrand de Cagny, Michel Slama
Severe varicella-zoster virus pneumonia: a multicenter cohort study
Adrien Mirouse, Philippe Vignon, Prescillia Piron, René Robert, Laurent Papazian, Guillaume Géri, Pascal Blanc, Christophe Guitton, Claude Guérin, Naïke Bigé, Antoine Rabbat, Aurélie Lefebvre, Keyvan Razazi, Muriel Fartoukh, Eric Mariotte, Lila Bouadma, Jean-Damien Ricard, Amélie Seguin, Bertrand Souweine, Anne-Sophie Moreau, Stanislas Faguer, Arnaud Mari, Julien Mayaux, Francis Schneider, Annabelle Stoclin, Pierre Perez, Julien Maizel, Charles Lafon, Frédérique Ganster, Laurent Argaud, Christophe Girault, François Barbier, Lucien Lecuyer, Jérôme Lambert, Emmanuel Canet
Between chromatin and SNPs: genetic variability and the susceptibility to acute kidney injury
Hernando Gómez
A randomized controlled pilot study to evaluate the effect of an enteral formulation designed to improve gastrointestinal tolerance in the critically ill patient—the SPIRIT trial
Stephan M. Jakob, Lukas Bütikofer, David Berger, Michael Coslovsky, Jukka Takala
Effect of perioperative goal-directed hemodynamic therapy on postoperative recovery following major abdominal surgery—a systematic review and meta-analysis of randomized controlled trials
Yanxia Sun, Fang Chai, Chuxiong Pan, Jamie Lee Romeiser, Tong J. Gan
A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial
Paul E. Wischmeyer, Michel Hasselmann, Christine Kummerlen, Rosemary Kozar, Demetrios James Kutsogiannis, Constantine J. Karvellas, Beth Besecker, David K. Evans, Jean-Charles Preiser, Leah Gramlich, Khursheed Jeejeebhoy, Rupinder Dhaliwal, Xuran Jiang, Andrew G. Day, Daren K. Heyland
Systematic assessment of advanced respiratory physiology: precision medicine entering real-life ICU?
Tommaso Mauri, Giacomo Grasselli, Antonio Pesenti
Antiarrhythmic drugs in out-of-hospital cardiac arrest: is there a place for potassium chloride?
Romain Jouffroy, Benoît Vivien
Assessment of pulmonary mechanics in mechanical ventilation
Federico Gordo, Beatriz Lobo-Valbuena
Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?
Chih-Chung Shiao, Tao-Min Huang, Herbert D. Spapen, Patrick M. Honore, Vin-Cent Wu
Transpulmonary thermodilution: advantages and limits
Xavier Monnet, Jean-Louis Teboul
Retinal involvement in sepsis: from the eye of the patient to the eye of the beholder
E. Christiaan Boerma
Human leukocyte antigen-DR expression might predict outcomes in severe sepsis, but diabetes mellitus cannot be ignored
Jun Li, Xianshi Zhou, Ye Ye, Guanghua Guanghua
Early versus late initiation of renal replacement therapy impacts mortality in patients with acute kidney injury post cardiac surgery: a meta-analysis
Honghong Zou, Qianwen Hong, Gaosi XU
On-line plasma lactate concentration monitoring in critically ill patients
Christian De Tymowski, Sabri Soussi, François Depret, Matthieu Legrand
Untangling glycaemia and mortality in critical care
Vincent Uyttendaele, Jennifer L. Dickson, Geoffrey M. Shaw, Thomas Desaive, J. Geoffrey Chase
Protein S100 as outcome predictor after out-of-hospital cardiac arrest and targeted temperature management at 33 °C and 36 °C
Pascal Stammet, Josef Dankiewicz, Niklas Nielsen, François Fays, Olivier Collignon, Christian Hassager, Michael Wanscher, Johan Undèn, Jorn Wetterslev, Tommaso Pellis, Anders Aneman, Jan Hovdenes, Matt P. Wise, Georges Gilson, David Erlinge, Janneke Horn, Tobias Cronberg, Michael Kuiper, Jesper Kjaergaard, Yvan Gasche, Yvan Devaux, Hans Friberg
Nucleated red blood cells, critical illness survivors and postdischarge outcomes: a cohort study
Steven W. Purtle, Clare M. Horkan, Takuhiro Moromizato, Fiona K. Gibbons, Kenneth B. Christopher
Marked regional endothelial dysfunction in mottled skin area in patients with severe infections
Simon Bourcier, Jérémie Joffre, Vincent Dubée, Gabriel Preda, Jean-Luc Baudel, Naïke Bigé, Guillaume Leblanc, Bernard I. Levy, Bertrand Guidet, Eric Maury, Hafid Ait-Oufella
Impact of Gram stain results on initial treatment selection in patients with ventilator-associated pneumonia: a retrospective analysis of two treatment algorithms
Jumpei Yoshimura, Takahiro Kinoshita, Kazuma Yamakawa, Asako Matsushima, Naoki Nakamoto, Toshimitsu Hamasaki, Satoshi Fujimi
Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR)
Tobias Wengenmayer, Stephan Rombach, Florian Ramshorn, Paul Biever, Christoph Bode, Daniel Duerschmied, Dawid L. Staudacher
Transcriptome modulation by hydrocortisone in severe burn shock: ancillary analysis of a prospective randomized trial
Jonathan Plassais, Fabienne Venet, Marie-Angélique Cazalis, Diane Le Quang, Alexandre Pachot, Guillaume Monneret, Sylvie Tissot, Julien Textoris
Hemoglobin concentrations and RBC transfusion thresholds in patients with acute brain injury: an international survey
Rafael Badenes, Mauro Oddo, José I. Suarez, Massimo Antonelli, Jeffrey Lipman, Giuseppe Citerio, Fabio Silvio Taccone
Low-volume resuscitation with normal saline is associated with microvascular endothelial dysfunction after hemorrhage in rats, compared to colloids and balanced crystalloids
Luciana N. Torres, Kevin K. Chung, Christi L. Salgado, Michael A. Dubick, Ivo P. Torres Filho
Evaluation of early antimicrobial therapy adaptation guided by the BetaLACTA® test: a case-control study
Marc Garnier, Sacha Rozencwajg, Tài Pham, Sophie Vimont, Clarisse Blayau, Mehdi Hafiani, Jean-Pierre Fulgencio, Francis Bonnet, Jean-Luc Mainardi, Guillaume Arlet, Muriel Fartoukh, Salah Gallah, Christophe Quesnel
Treatment of severe hospital-acquired and ventilator-associated pneumonia: a systematic review of inclusion and judgment criteria used in randomized controlled trials
Emmanuel Weiss, Wafa Essaied, Christophe Adrie, Jean-Ralph Zahar, Jean-François Timsit
Does anti-VEGF bevacizumab improve survival in experimental sepsis?
Emmanuel Besnier, Ebba Brakenhielm, Vincent Richard, Fabienne Tamion
The usability of ventilators: a comparative evaluation of use safety and user experience—an editorial response
Edwin Coombs
How to remove the grey area between ventilator-associated pneumonia and ventilator-associated tracheobronchitis?
Yuetian Yu, Cheng Zhu, Chunyan Liu, Yuan Gao
Is it time to consider visual feedback systems the gold standard for chest compression skill acquisition?
Andrea Cortegiani, Vincenzo Russotto, Enrico Baldi, Enrico Contri, Santi Maurizio Raineri, Antonino Giarratano
Limited evidence to recommend lactate kinetics-guided therapy
Daniel O. Thomas-Rüddel, Michael Bauer
Do we need another prognostic score for cardiogenic shock patients with ECMO?
Sébastien Champion
Open-chest versus closed-chest cardiopulmonary resuscitation in blunt trauma: analysis of a nationwide trauma registry
Akira Endo, Atsushi Shiraishi, Yasuhiro Otomo, Makoto Tomita, Hiroki Matsui, Kiyoshi Murata
New setting of neurally adjusted ventilatory assist for noninvasive ventilation by facial mask: a physiologic study
Federico Longhini, Chun Pan, Jianfeng Xie, Gianmaria Cammarota, Andrea Bruni, Eugenio Garofalo, Yi Yang, Paolo Navalesi, Haibo Qiu
The common promoter polymorphism rs11666254 downregulates FPR2/ALX expression and increases risk of sepsis in patients with severe trauma
Han Zhang, Yao Lu, Guixiang Sun, Fang Teng, Nian Luo, Jianxin Jiang, Aiqing Wen
Association of neuron-specific enolase values with outcomes in cardiac arrest survivors is dependent on the time of sample collection
Dagmar Vondrakova, Andreas Kruger, Marek Janotka, Filip Malek, Vlasta Dudkova, Petr Neuzil, Petr Ostadal
Double carbapenem as a rescue strategy for the treatment of severe carbapenemase-producing Klebsiella pneumoniae infections: a two-center, matched case–control study
Gennaro De Pascale, Gennaro Martucci, Luca Montini, Giovanna Panarello, Salvatore Lucio Cutuli, Daniele Di Carlo, Valentina Di Gravio, Roberta Di Stefano, Guido Capitanio, Maria Sole Vallecoccia, Piera Polidori, Teresa Spanu, Antonio Arcadipane, Massimo Antonelli
Decisions regarding admission to the ICU and international initiatives to improve the decision-making process
Christopher Bassford
Detecting impaired myocardial relaxation in sepsis with a novel tissue Doppler parameter (septal e′/s′)
David J. Clancy, Michel Slama, Stephen Huang, Timothy Scully, Anthony S. McLean, Sam R. Orde
Combined use of serum (1,3)-β-d-glucan and procalcitonin for the early differential diagnosis between candidaemia and bacteraemia in intensive care units
Daniele Roberto Giacobbe, Malgorzata Mikulska, Mario Tumbarello, Elisa Furfaro, Marzia Spadaro, Angela Raffaella Losito, Alessio Mesini, Gennaro De Pascale, Anna Marchese, Marco Bruzzone, Paolo Pelosi, Michele Mussap, Alexandre Molin, Massimo Antonelli, Brunella Posteraro, Maurizio Sanguinetti, Claudio Viscoli, Valerio Del Bono
Electrical impedance tomography for predicting failure of spontaneous breathing trials in patients with prolonged weaning
Johannes Bickenbach, Michael Czaplik, Mareike Polier, Gernot Marx, Nikolaus Marx, Michael Dreher
Protocol based invasive intracranial pressure monitoring in acute liver failure: feasibility, safety and impact on management
Venkatakrishna Rajajee, Robert J. Fontana, Anthony J. Courey, Parag G. Patil
Outcomes of subsyndromal delirium in ICU: a systematic review and meta-analysis
Rodrigo B. Serafim, Marcio Soares, Fernando A. Bozza, José R. Lapa e Silva, Felipe Dal-Pizzol, Maria Carolina Paulino, Pedro Povoa, Jorge I. F. Salluh
Enhanced antimicrobial de-escalation for pneumonia in mechanically ventilated patients: a cross-over study
Tracy Trupka, Kristen Fisher, Scott T. Micek, Paul Juang, Marin H. Kollef
Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock
Yusuke Iizuka, Masamitsu Sanui, Yusuke Sasabuchi, Alan Kawarai Lefor, Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Kazuma Yamakawa, Daisuke Kudo, Kohei Takimoto, Toshihiko Mayumi, Takeo Azuhata, Fumihito Ito, Shodai Yoshihiro, Katsura Hayakawa, Tsuyoshi Nakashima, Takayuki Ogura, Eiichiro Noda, Yoshihiko Nakamura, Ryosuke Sekine, Yoshiaki Yoshikawa, Motohiro Sekino, Keiko Ueno, Yuko Okuda, Masayuki Watanabe, Akihito Tampo, Nobuyuki Saito, Yuya Kitai, Hiroki Takahashi, Iwao Kobayashi, Yutaka Kondo, Wataru Matsunaga, Sho Nachi, Toru Miike, Hiroshi Takahashi, Shuhei Takauji, Kensuke Umakoshi, Takafumi Todaka, Hiroshi Kodaira, Kohkichi Andoh, Takehiko Kasai, Yoshiaki Iwashita, Hideaki Arai, Masato Murata, Masahiro Yamane, Kazuhiro Shiga, Naoto Hori
Erratum to: P95 B-lines on chest ultrasound predicts elevated left ventricular diastolic pressures
Z. Bitar, O. Maadarani, R. Al Hamdan
The future of mechanical ventilation: lessons from the present and the past
Luciano Gattinoni, John J. Marini, Francesca Collino, Giorgia Maiolo, Francesca Rapetti, Tommaso Tonetti, Francesco Vasques, Michael Quintel
High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis
Huiying Zhao, Huixia Wang, Feng Sun, Shan Lyu, Youzhong An
Association of baseline steroid use with long-term rates of infection and sepsis in the REGARDS cohort
Ninad S. Chaudhary, John P. Donnelly, Justin X. Moore, John W. Baddley, Monika M. Safford, Henry E. Wang
Monocyte programmed death ligand-1 expression is an early marker for predicting infectious complications in acute pancreatitis
Tingting Pan, Tianyun Zhou, Lei Li, Zhaojun Liu, Ying Chen, Enqiang Mao, Meiling Li, Hongping Qu, Jialin Liu
Erratum to: Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism
Pär Ingemar Johansson, Jakob Stensballe, Sisse Rye Ostrowski
Severity of acute gastrointestinal injury grade is a predictor of all-cause mortality in critically ill patients: a multicenter, prospective, observational study
Bangchuan Hu, Renhua Sun, Aiping Wu, Yin Ni, Jingquan Liu, Feng Guo, Lijun Ying, Guoping Ge, Aijun Ding, Yunchao Shi, Changwen Liu, Lei Xu, Ronglin Jiang, Jun Lu, Ronghai Lin, Yannan Zhu, Weidong Wu, Bo Xie
Markers of nitric oxide are associated with sepsis severity: an observational study
Martin Sebastian Winkler, Stefan Kluge, Maximilian Holzmann, Eileen Moritz, Linda Robbe, Antonia Bauer, Corinne Zahrte, Marion Priefler, Edzard Schwedhelm, Rainer H. Böger, Alwin E. Goetz, Axel Nierhaus, Christian Zoellner
Prolonged acute care and post-acute care admission and recovery of physical function in survivors of acute respiratory failure: a secondary analysis of a randomized controlled trial
Anna Neumeier, Amy Nordon-Craft, Dan Malone, Margaret Schenkman, Brendan Clark, Marc Moss
Evidence of altered haemostasis in an ovine model of venovenous extracorporeal membrane oxygenation support
Margaret R. Passmore, Yoke L. Fung, Gabriela Simonova, Samuel R. Foley, Sara D. Diab, Kimble R. Dunster, Michelle M. Spanevello, Charles I. McDonald, John-Paul Tung, Natalie M. Pecheniuk, Karen Hay, Kiran Shekar, John F. Fraser
A systematic review and meta-analysis comparing mortality in pre-hospital tracheal intubation to emergency department intubation in trauma patients
Espen Fevang, Zane Perkins, David Lockey, Elisabeth Jeppesen, Hans Morten Lossius
Metabolome alterations in severe critical illness and vitamin D status
Jessica Lasky-Su, Amber Dahlin, Augusto A. Litonjua, Angela J. Rogers, Michael J. McGeachie, Rebecca M. Baron, Lee Gazourian, Diana Barragan-Bradford, Laura E. Fredenburgh, Augustine M. K. Choi, Kris M. Mogensen, Sadeq A. Quraishi, Karin Amrein, Kenneth B. Christopher
Inhaled AP301 for treatment of pulmonary edema in mechanically ventilated patients with acute respiratory distress syndrome: a phase IIa randomized placebo-controlled trial
Katharina Krenn, Rudolf Lucas, Adrien Croizé, Stefan Boehme, Klaus Ulrich Klein, Robert Hermann, Klaus Markstaller, Roman Ullrich
Care at a non-university hospital: an independent risk factor for mortality in ARDS?
Bourke Tillmann, Hannah Wunsch
Targeted therapeutic mild hypercapnia after cardiac arrest
Glenn M. Eastwood, Alistair Nichol, Matt P. Wise
Continuous glucose monitoring in the ICU: clinical considerations and consensus
James S. Krinsley, J. Geoffrey Chase, Jan Gunst, Johan Martensson, Marcus J. Schultz, Fabio S. Taccone, Jan Wernerman, Julien Bohe, Christophe De Block, Thomas Desaive, Pierre Kalfon, Jean-Charles Preiser
Dexmedetomidine as a promising prevention strategy for cardiac surgery-associated acute kidney injury: a meta-analysis
Rui Shi, Hong-Tao Tie
Driving pressure: a marker of severity, a safety limit, or a goal for mechanical ventilation?
Guillermo Bugedo, Jaime Retamal, Alejandro Bruhn
Plasma concentrations of caspofungin in a critically ill patient with morbid obesity
Rafael Ferriols-Lisart, Gerardo Aguilar, Alejandro Pérez-Pitarch, Jaume Puig, Carlos Ezquer-Garín, Manuel Alós
Response to: Understanding the null hypothesis (H0) in non-inferiority trials
Xiang Zhou, Dawei Liu, Longxiang Su
Hyperglycaemia in critically ill patients: the immune system’s sweet tooth
Gustav van Niekerk, Tanja Davis, Anna-Mart Engelbrecht
Confounding variables impacting the association between duration of veno-arterial extracorporeal life support and mortality
Jesse Kiefer, Robert E. Freundlich
Understanding fluid administration approaches in children with co-morbidities and septic shock
Niranjan Kissoon
Relapsing fever in young refugees from East Africa
Spinello Antinori, Valeria Colombo, Mario Corbellino
Could remifentanil reduce duration of mechanical ventilation in comparison with other opioids for mechanically ventilated patients? A systematic review and meta-analysis
Yibing Zhu, Yinhua Wang, Bin Du, Xiuming Xi
What is the impact of the fluid challenge technique on diagnosis of fluid responsiveness? A systematic review and meta-analysis
Laura Toscani, Hollmann D. Aya, Dimitra Antonakaki, Davide Bastoni, Ximena Watson, Nish Arulkumaran, Andrew Rhodes, Maurizio Cecconi
Rapid identification of antimicrobial resistance patterns allows a faster antibiotic adequacy
Adrian Ceccato, Otavio T. Ranzani, Antoni Torres
Recovery from critical illness-induced organ failure: the role of autophagy
Jan Gunst
Voluntary running exercise protects against sepsis-induced early inflammatory and pro-coagulant responses in aged mice
Karel Tyml, Scott Swarbreck, Cynthia Pape, Dan Secor, James Koropatnick, Qingping Feng, Ruud A. W. Veldhuizen, Sean E. Gill
Incidence, prevalence, and management of MRSA bacteremia across patient populations—a review of recent developments in MRSA management and treatment
Ali Hassoun, Peter K. Linden, Bruce Friedman
Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial
Jasperina Dubois, Tom Van Herpe, Roosmarijn T. van Hooijdonk, Ruben Wouters, Domien Coart, Pieter Wouters, Aimé Van Assche, Guy Veraghtert, Bart De Moor, Joost Wauters, Alexander Wilmer, Marcus J. Schultz, Greet Van den Berghe, Dieter Mesotten
Selepressin, a novel selective vasopressin V1A agonist, is an effective substitute for norepinephrine in a phase IIa randomized, placebo-controlled trial in septic shock patients
James A. Russell, Jean-Louis Vincent, Anne Louise Kjølbye, Håkan Olsson, Allan Blemings, Herbert Spapen, Peder Carl, Pierre-Francois Laterre, Lars Grundemar
Dehydroepiandrosterone sulfate and dehydroepiandrosterone sulfate/cortisol ratio in cirrhotic patients with septic shock: another sign of hepatoadrenal syndrome?
Ming-Hung Tsai, Hui-Chun Huang, Yun-Shing Peng, Yung-Chang Chen, Ya-Chung Tian, Chih-Wei Yang, Jau-Min Lien, Ji-Tseng Fang, Cheng-Shyong Wu, Sen-Yung Hsieh, Fa-Yauh Lee
Point-of-care ultrasonography: a practical step in the path to precision in critical care
Gentle Sunder Shrestha
Early troponin I in critical illness and its association with hospital mortality: a cohort study
Annemarie B. Docherty, Malcolm Sim, Joao Oliveira, Michael Adlam, Marlies Ostermann, Timothy S. Walsh, John Kinsella, Nazir I. Lone
Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype
Pavan K. Bhatraju, Cassianne Robinson-Cohen, Carmen Mikacenic, Susanna Harju-Baker, Victoria Dmyterko, Natalie S. J. Slivinski, W. Conrad Liles, Jonathan Himmelfarb, Susan R. Heckbert, Mark M. Wurfel
The association of early combined lactate and glucose levels with subsequent renal and liver dysfunction and hospital mortality in critically ill patients
Pedro Freire Jorge, Nienke Wieringa, Eva de Felice, Iwan C. C. van der Horst, Annemieke Oude Lansink, Maarten W. Nijsten
Disseminated intravascular coagulation with increased fibrinolysis during the early phase of isolated traumatic brain injury
Takeshi Wada, Satoshi Gando, Kunihiko Maekaw, Kenichi Katabami, Hisako Sageshima, Mineji Hayakawa, Atsushi Sawamura
Costs and expected gain in lifetime health from intensive care versus general ward care of 30,712 individual patients: a distribution-weighted cost-effectiveness analysis
Frode Lindemark, Øystein A. Haaland, Reidar Kvåle, Hans Flaatten, Ole F. Norheim, Kjell A. Johansson
Recorded time periods of bispectral index values equal to zero predict neurological outcome after out-of-hospital cardiac arrest
Ward Eertmans, Cornelia Genbrugge, Gilles Haesevoets, Jo Dens, Willem Boer, Frank Jans, Cathy De Deyne
Hyperfibrinolysis in severe isolated traumatic brain injury may occur without tissue hypoperfusion: a retrospective observational multicentre study
Mineji Hayakawa, Kunihiko Maekawa, Shigeki Kushimoto, Hiroshi Kato, Junichi Sasaki, Hiroshi Ogura, Tetsuya Matsuoka, Toshifumi Uejima, Naoto Morimura, Hiroyasu Ishikura, Akiyoshi Hagiwara, Munekazu Takeda, Naoyuki Kaneko, Daizoh Saitoh, Daisuke Kudo, Takashi Kanemura, Takayuki Shibusawa, Shintaro Furugori, Yoshihiko Nakamura, Atsushi Shiraishi, Kiyoshi Murata, Gou Mayama, Arino Yaguchi, Shiei Kim, Osamu Takasu, Kazutaka Nishiyama
Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care
Paul Zajic, Peter Bauer, Andrew Rhodes, Rui Moreno, Tobias Fellinger, Barbara Metnitz, Faidra Stavropoulou, Martin Posch, Philipp G. H. Metnitz
Variability of response to the fluid bolus is again demonstrated
Ellis R. Muggleton
Ultrasound-guided central venous catheter placement: a structured review and recommendations for clinical practice
Bernd Saugel, Thomas W. L. Scheeren, Jean-Louis Teboul
The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review
Danielle E. Bear, Liesl Wandrag, Judith L. Merriweather, Bronwen Connolly, Nicholas Hart, Michael P. W. Grocott
Current clinical nutrition practices in critically ill patients in Latin America: a multinational observational study
Karin Papapietro Vallejo, Carolina Méndez Martínez, Alfredo A. Matos Adames, Vanessa Fuchs-Tarlovsky, Guillermo Carlos Contreras Nogales, Roger Enrique Riofrio Paz, Mario Ignacio Perman, Maria Isabel Toulson Davisson Correia, Dan Linetzky Waitzberg
A systematic review of diagnostic methods to differentiate acute lung injury/acute respiratory distress syndrome from cardiogenic pulmonary edema
Kosaku Komiya, Tomohiro Akaba, Yuji Kozaki, Jun-ichi Kadota, Bruce K. Rubin
Markers of acute kidney injury in patients with sepsis: the role of soluble thrombomodulin
Shinshu Katayama, Shin Nunomiya, Kansuke Koyama, Masahiko Wada, Toshitaka Koinuma, Yuya Goto, Ken Tonai, Jun Shima
Immunosuppression and herpes viral reactivation in intensive care unit patients: one size does not fit all
Julien Textoris, François Mallet
Renal replacement therapy after cardiac surgery: do not ask “When”, ask “Why”
Stéphane Gaudry, David Hajage, Didier Dreyfuss
Hydrolysed protein enteral nutrition is not superior to polymeric whole protein feeding with regard to gastrointestinal feeding tolerance and feeding adequacy
Arthur R. H. van Zanten, Gunnar Elke
Variation in monitoring and treatment policies for intracranial hypertension in traumatic brain injury: a survey in 66 neurotrauma centers participating in the CENTER-TBI study
Maryse C. Cnossen, Jilske A. Huijben, Mathieu van der Jagt, Victor Volovici, Thomas van Essen, Suzanne Polinder, David Nelson, Ari Ercole, Nino Stocchetti, Giuseppe Citerio, Wilco C. Peul, Andrew I. R. Maas, David Menon, Ewout W. Steyerberg, Hester F. Lingsma, Hadie Adams, Masala Alessandro, Judith Allanson, Krisztina Amrein, Norberto Andaluz, Nada Andelic, Nanni Andrea, Lasse Andreassen, Audny Anke, Anna Antoni, Hilko Ardon, Gérard Audibert, Kaspars Auslands, Philippe Azouvi, Camelia Baciu, Andrew Bacon, Rafael Badenes, Trevor Baglin, Ronald Bartels, Pál Barzó, Ursula Bauerfeind, Ronny Beer, Francisco Javier Belda, Bo-Michael Bellander, Antonio Belli, Rémy Bellier, Habib Benali, Thierry Benard, Maurizio Berardino, Luigi Beretta, Christopher Beynon, Federico Bilotta, Harald Binder, Erta Biqiri, Morten Blaabjerg, Lund Stine Borgen, Pierre Bouzat, Peter Bragge, Alexandra Brazinova, Felix Brehar, Camilla Brorsson, Andras Buki, Monika Bullinger, Veronika Bučková, Emiliana Calappi, Peter Cameron, Guillermo Carbayo Lozano, Elsa Carise, K. Carpenter, Ana M. Castaño-León, Francesco Causin, Giorgio Chevallard, Arturo Chieregato, Giuseppe Citerio, Maryse Cnossen, Mark Coburn, Jonathan Coles, Jamie D. Cooper, Marta Correia, Amra Covic, Nicola Curry, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, François Damas, Pierre Damas, Helen Dawes, Véronique De Keyser, Francesco Della Corte, Bart Depreitere, Shenghao Ding, Diederik Dippel, Kemal Dizdarevic, Guy-Loup Dulière, Adelaida Dzeko, George Eapen, Heiko Engemann, Ari Ercole, Patrick Esser, Erzsébet Ezer, Martin Fabricius, Valery L. Feigin, Junfeng Feng, Kelly Foks, Francesca Fossi, Gilles Francony, Janek Frantzén, Ulderico Freo, Shirin Frisvold, Alex Furmanov, Pablo Gagliardo, Damien Galanaud, Guoyi Gao, Karin Geleijns, Alexandre Ghuysen, Benoit Giraud, Ben Glocker, Pedro A. Gomez, Francesca Grossi, Russell L. Gruen, Deepak Gupta, Juanita A. Haagsma, Ermin Hadzic, Iain Haitsma, Jed A. Hartings, Raimund Helbok, Eirik Helseth, Daniel Hertle, Sean Hill, Astrid Hoedemaekers, Stefan Hoefer, Peter J. Hutchinson, Asta Kristine Håberg, Bram Jacobs, Ivan Janciak, Koen Janssens, Ji-yao Jiang, Kelly Jones, Jean-Pierre Kalala, Konstantinos Kamnitsas, Mladen Karan, Jana Karau, Ari Katila, Maija Kaukonen, David Keeling, Thomas Kerforne, Naomi Ketharanathan, Johannes Kettunen, Riku Kivisaari, Angelos G. Kolias, Bálint Kolumbán, Erwin Kompanje, Daniel Kondziella, Lars-Owe Koskinen, Noémi Kovács, Ferenc Kálovits, Alfonso Lagares, Linda Lanyon, Steven Laureys, Martin Lauritzen, Fiona Lecky, Christian Ledig, Rolf Lefering, Valerie Legrand, Jin Lei, Leon Levi, Roger Lightfoot, Hester Lingsma, Dirk Loeckx, Angels Lozano, Roger Luddington, Chantal Luijten-Arts, I. R. Maas Andrew, Stephen MacDonald, Charles MacFayden, Marc Maegele, Marek Majdan, Sebastian Major, Alex Manara, Pauline Manhes, Geoffrey Manley, Didier Martin, Costanza Martino, Armando Maruenda, Hugues Maréchal, Dagmara Mastelova, Julia Mattern, Catherine McMahon, Béla Melegh, David Menon, Tomas Menovsky, Cristina Morganti-Kossmann, Davide Mulazzi, Manuel Mutschler, Holger Mühlan, Ancuta Negru, David Nelson, Eddy Neugebauer, Virginia Newcombe, Quentin Noirhomme, József Nyirádi, Mauro Oddo, Annemarie Oldenbeuving, Matej Oresic, Fabrizio Ortolano, Aarno Palotie, Paul M. Parizel, Adriana Patruno, Jean-François Payen, Natascha Perera, Vincent Perlbarg, Paolo Persona, Wilco Peul, Nicolas Pichon, Henning Piilgaard, Anna Piippo, Sébastien Pili Floury, Matti Pirinen, Horia Ples, Suzanne Polinder, Inigo Pomposo, Marek Psota, Pim Pullens, Louis Puybasset, Arminas Ragauskas, Rahul Raj, Malinka Rambadagalla, Veronika Rehorčíková, Jonathan Rhodes, Sylvia Richardson, Samuli Ripatti, Saulius Rocka, Nicolas Rodier, Cecilie Roe, Olav Roise, Gerwin Roks, Pauline Romegoux, Jonathan Rosand, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Tim Rostalski, Daniel Rueckert, Felix Ruiz de Arcaute, Martin Rusnák, Marco Sacchi, Barbara Sahakian, Juan Sahuquillo, Oliver Sakowitz, Francesca Sala, Paola Sanchez-Pena, Renan Sanchez-Porras, Janos Sandor, Edgar Santos, Nadine Sasse, Luminita Sasu, Davide Savo, Inger Schipper, Barbara Schlößer, Silke Schmidt, Annette Schneider, Herbert Schoechl, Guus Schoonman, Rico Frederik Schou, Elisabeth Schwendenwein, Michael Schöll, Özcan Sir, Toril Skandsen, Lidwien Smakman, Dirk Smeets, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Simon Stanworth, Katrin Stegemann, Nicole Steinbüchel, Robert Stevens, William Stewart, Ewout W. Steyerberg, Nino Stocchetti, Nina Sundström, Anneliese Synnot, József Szabó, Jeannette Söderberg, Fabio Silvio Taccone, Viktória Tamás, Päivi Tanskanen, Alexandru Tascu, Mark Steven Taylor, Braden Te Ao, Olli Tenovuo, Guido Teodorani, Alice Theadom, Matt Thomas, Dick Tibboel, Christos Tolias, Jean-Flory Luaba Tshibanda, Cristina Maria Tudora, Peter Vajkoczy, Egils Valeinis, Wim Van Hecke, Dominique Van Praag, Dirk Van Roost, Eline Van Vlierberghe, Thijs Vande Vyvere, Audrey Vanhaudenhuyse, Alessia Vargiolu, Emmanuel Vega, Jan Verheyden, Paul M. Vespa, Anne Vik, Rimantas Vilcinis, Giacinta Vizzino, Carmen Vleggeert-Lankamp, Victor Volovici, Peter Vulekovic, Zoltán Vámos, Derick Wade, Kevin K. W. Wang, Lei Wang, Eno Wildschut, Guy Williams, Lisette Willumsen, Adam Wilson, Lindsay Wilson, Maren K. L. Winkler, Peter Ylén, Alexander Younsi, Menashe Zaaroor, Zhiqun Zhang, Zelong Zheng, Fabrizio Zumbo, Stefanie de Lange, Godard C. W. de Ruiter, Hugo den Boogert, Jeroen van Dijck, Thomas A. van Essen, Caroline van Heugten, Mathieu van der Jagt, Joukje van der Naalt
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome
Akram Khan, Cody Benthin, Brian Zeno, Timothy E. Albertson, John Boyd, Jason D. Christie, Richard Hall, Germain Poirier, Juan J. Ronco, Mark Tidswell, Kelly Hardes, William M. Powley, Tracey J. Wright, Sarah K. Siederer, David A. Fairman, David A. Lipson, Andrew I. Bayliffe, Aili L. Lazaar
Loxapine to control agitation during weaning from mechanical ventilation
Stéphane Gaudry, Benjamin Sztrymf, Romain Sonneville, Bruno Megarbane, Guillaume Van Der Meersch, Dominique Vodovar, Yves Cohen, Jean-Damien Ricard, David Hajage, Laurence Salomon, Didier Dreyfuss
Targeted therapeutic mild hypercapnia after cardiac arrest: a part of the bundle of care for mitigating secondary injury after cardiac arrest
Romain Jouffroy, Benoît Vivien
Traversing the valley of glycemic control despair
J. Geoffrey Chase, Jennifer L. Dickson
Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury
Chen-Fei Zheng, Wen-Yue Liu, Fang-Fang Zeng, Ming-Hua Zheng, Hong-Ying Shi, Ying Zhou, Jing-Ye Pan
Satisfaction with quality of ICU care for patients and families: the euroQ2 project
Hanne Irene Jensen, Rik T. Gerritsen, Matty Koopmans, Lois Downey, Ruth A. Engelberg, J. Randall Curtis, Peter E. Spronk, Jan G. Zijlstra, Helle Ørding
Respiratory support in patients with acute respiratory distress syndrome: an expert opinion
Davide Chiumello, Laurent Brochard, John J. Marini, Arthur S. Slutsky, Jordi Mancebo, V. Marco Ranieri, B. Taylor Thompson, Laurent Papazian, Marcus J. Schultz, Marcelo Amato, Luciano Gattinoni, Alain Mercat, Antonio Pesenti, Daniel Talmor, Jean-Louis Vincent
Accounting for single center effects in systematic reviews cannot be overlooked
Bruno Adler Maccagnan Pinheiro Besen, Marcelo Park, Antonio Paulo Nassar Jr
Main limitations of transpulmonary thermodilution: set targets
Manuel Sánchez-Sánchez, Eva Herrero, Lucia Cachafeiro, Eva Flores, Alexander Agrifoglio, Belén Civantos, Abelardo García-de-Lorenzo
Effect of extended visiting hours on physician distractions in the ICU: a before-and-after study
Kay Choong See, Xie Ying Song, Han Tun Aung
Limited evidence to recommend against open chest cardiopulmonary resuscitation in blunt trauma
Stefano Malinverni, Pierre Mols
Undetectable haptoglobin is associated with major adverse kidney events in critically ill burn patients
François Dépret, Chloé Dunyach, Christian De Tymowski, Maïté Chaussard, Aurélien Bataille, Axelle Ferry, Nabila Moreno, Alexandru Cupaciu, Sabri Soussi, Mourad Benyamina, Alexandre Mebazaa, Kevin Serror, Marc Chaouat, Jean-Pierre Garnier, Romain Pirracchio, Matthieu Legrand
Pre-emptive and therapeutic value of blocking bacterial attachment to the endothelial alphaVbeta3 integrin with cilengitide in sepsis
Carolina D. Garciarena, Tony M. McHale, Ignacio Martin-Loeches, Steve W. Kerrigan
Systemic impact on secondary brain aggravation due to ischemia/reperfusion injury in post-cardiac arrest syndrome: a prospective observational study using high-mobility group box 1 protein
Atsunori Sugita, Kosaku Kinoshita, Atsushi Sakurai, Nobutaka Chiba, Junko Yamaguchi, Tsukasa Kuwana, Nami Sawada, Satoshi Hori
Blind bedside postpyloric placement of spiral tube as rescue therapy in critically ill patients: a prospective, tricentric, observational study
Bo Lv, Linhui Hu, Lifang Chen, Bei Hu, Yanlin Zhang, Heng Ye, Cheng Sun, Xiunong Zhang, Huilan Lan, Chunbo Chen
Evaluating physical functioning in critical care: considerations for clinical practice and research
Selina M. Parry, Minxuan Huang, Dale M. Needham
Simplified prognostic model for critically ill patients in resource limited settings in South Asia
Rashan Haniffa, Mavuto Mukaka, Sithum Bandara Munasinghe, Ambepitiyawaduge Pubudu De Silva, Kosala Saroj Amarasiri Jayasinghe, Abi Beane, Nicolette de Keizer, Arjen M. Dondorp
Association between kidney intracapsular pressure and ultrasound elastography
Kianoush B. Kashani, Shennen A. Mao, Sami Safadi, Bruce P. Amiot, Jaime M. Glorioso, John C. Lieske, Scott L. Nyberg, Xiaoming Zhang
Levosimendan for patients with severely reduced left ventricular systolic function and/or low cardiac output syndrome undergoing cardiac surgery: a systematic review and meta-analysis
Filippo Sanfilippo, Joshua B. Knight, Sabino Scolletta, Cristina Santonocito, Federico Pastore, Ferdinando L. Lorini, Luigi Tritapepe, Andrea Morelli, Antonio Arcadipane
Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials
Qi-Hong Chen, Rui-Qiang Zheng, Hua Lin, Jun Shao, Jiang-quan Yu, Hua-Ling Wang
Predictors of diffuse alveolar damage in patients with acute respiratory distress syndrome: a retrospective analysis of clinical autopsies
Arnaud W. Thille, Oscar Peñuelas, José A. Lorente, Pilar Fernández-Segoviano, José-Maria Rodriguez, José-Antonio Aramburu, Julian Panizo, Andres Esteban, Fernando Frutos-Vivar
Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis
Namkje A. R. Vellinga, E. Christiaan Boerma, Matty Koopmans, Abele Donati, Arnaldo Dubin, Nathan I. Shapiro, Rupert M. Pearse, Peter H. J. van der Voort, Arjen M. Dondorp, Tony Bafi, Michael Fries, Tulin Akarsu-Ayazoglu, Andrius Pranskunas, Steven Hollenberg, Gianmarco Balestra, Mat van Iterson, Farid Sadaka, Gary Minto, Ulku Aypar, F. Javier Hurtado, Giampaolo Martinelli, Didier Payen, Frank van Haren, Anthony Holley, Hernando Gomez, Ravindra L. Mehta, Alejandro H. Rodriguez, Carolina Ruiz, Héctor S. Canales, Jacques Duranteau, Peter E. Spronk, Shaman Jhanji, Sheena Hubble, Marialuisa Chierego, Christian Jung, Daniel Martin, Carlo Sorbara, Jan Bakker, Can Ince, E. C. Boerma, M. Koopmans, N. A. R. Vellinga, M. van Iterson, P. H. J. van der Voort, J. Bakker, P. E. Spronk, C. Ruiz, A. T. Bafi, A. Dubin, V. S. Kanoore Edul, H. S. Canales, F. J. Hurtado, S. M. Hollenberg, N. I. Shapiro, H. Gomez, F. G. Sadaka, R. Mehta, C. Jung, M. Fries, R. M. Pearse, D. S. Martin, P. Meale, S. Jhanji, G. Minto, G. Martinelli, M. Lombrano, S. M. A. Hubble, A. H. Rodriguez, I. Martin-Loeches, F. M. P. van Haren, A. Pranskunas, V. Pilvinis, A. Donati, C. Sorbara, M. L. Chierego, A. Holley, J. Duranteau, A. Harrois, D. Payen, G. M. Balestra, A. M. Dondorp, U. Aypar, J. van Bommel, G. Hernandez, F. Machado, V. Kanoore Edul, G. Lacuesta, M. Baz, U. Patel, M. Pinsky, K. Krause, A. Smith, C. Thorn, A. Forti, A. Comin, T. Pellis, J. Paratz, C. Damoisel, E. Bucher, R. Pattnaik, M. T. Herdman, B. Ayhan
Erratum to: Immunomodulation after ischemic stroke: potential mechanisms and implications for therapy
Cynthia Santos Samary, Paolo Pelosi, Pedro Leme Silva, Patricia Rieken Macedo Rocco
Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness
Christopher W. Seymour, Hernando Gomez, Chung-Chou H. Chang, Gilles Clermont, John A. Kellum, Jason Kennedy, Sachin Yende, Derek C. Angus
Finding the precision to improve outcome in patients after cardiac arrest
Gentle Sunder Shrestha
Individualized perfusion targets in hypoxic ischemic brain injury after cardiac arrest
Mypinder S. Sekhon, Donald E. Griesdale
Sleeping with the enemy: Clostridium difficile infection in the intensive care unit
Florian Prechter, Katrin Katzer, Michael Bauer, Andreas Stallmach
Three-dimensional ultrastructure of capillary endothelial glycocalyx under normal and experimental endotoxemic conditions
Hideshi Okada, Genzou Takemura, Kodai Suzuki, Kazumasa Oda, Chihiro Takada, Yasuaki Hotta, Nagisa Miyazaki, Akiko Tsujimoto, Isamu Muraki, Yoshiaki Ando, Ryogen Zaikokuji, Atsumu Matsumoto, Hiroki Kitagaki, Yuto Tamaoki, Takahiro Usui, Tomoaki Doi, Takahiro Yoshida, Shozo Yoshida, Hiroaki Ushikoshi, Izumi Toyoda, Shinji Ogura
Translational evidence for two distinct patterns of neuroaxonal injury in sepsis: a longitudinal, prospective translational study
Johannes Ehler, Lucinda K. Barrett, Valerie Taylor, Michael Groves, Francesco Scaravilli, Matthias Wittstock, Stephan Kolbaske, Annette Grossmann, Jörg Henschel, Martin Gloger, Tarek Sharshar, Fabrice Chretien, Francoise Gray, Gabriele Nöldge-Schomburg, Mervyn Singer, Martin Sauer, Axel Petzold
Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study
Lisa Ehmann, Michael Zoller, Iris K. Minichmayr, Christina Scharf, Barbara Maier, Maximilian V. Schmitt, Niklas Hartung, Wilhelm Huisinga, Michael Vogeser, Lorenz Frey, Johannes Zander, Charlotte Kloft
Aerosol delivery during invasive mechanical ventilation: a systematic review
Jonathan Dugernier, Stephan Ehrmann, Thierry Sottiaux, Jean Roeseler, Xavier Wittebole, Thierry Dugernier, François Jamar, Pierre-François Laterre, Gregory Reychler
Functional evaluation of sublingual microcirculation indicates successful weaning from VA-ECMO in cardiogenic shock
Sakir Akin, Dinis dos Reis Miranda, Kadir Caliskan, Osama I. Soliman, Goksel Guven, Ard Struijs, Robert J. van Thiel, Lucia S. Jewbali, Alexandre Lima, Diederik Gommers, Felix Zijlstra, Can Ince
Noninvasive ventilation in hypercapnic chronic obstructive pulmonary disease
Silvio A. Ñamendys-Silva
Lactate and stepwise lactate kinetics can be used to guide resuscitation
Xiang Zhou, Dawei Liu, Longxiang Su
Implementation of sepsis bundles in public hospitals in Brazil: a prospective study with heterogeneous results
Flavia Ribeiro Machado, Elaine Maria Ferreira, Pierre Schippers, Ilusca Cardoso de Paula, Letícia Sandre Vendrame Saes, Francisco Ivanildo de Oliveira Jr, Paula Tuma, Wilson Nogueira Filho, Felipe Piza, Sandra Guare, Cláudia Mangini, Gustavo Ziggiatti Guth, Luciano Cesar Pontes Azevedo, Flavio Geraldo Resende Freitas, Jose Luiz Gomes do Amaral, Nacime Salomão Mansur, Reinaldo Salomão
The impact of N-acetylcysteine and ascorbic acid in contrast-induced nephropathy in critical care patients: an open-label randomized controlled study
Eleni Palli, Demosthenes Makris, John Papanikolaou, Grigorios Garoufalis, Irini Tsilioni, Paris Zygoulis, Epaminondas Zakynthinos
Does enhanced antibiotic de-escalation really have no benefit in the ICU?
Shingo Ohki, Shinichiro Ohshimo, Nobuaki Shime
Icatibant as an early rescue therapy in hypovolemic shock with converting enzyme inhibitor treatment
Hélène Charbonneau, Marie Buléon, Benoit Richard, Nicolas Mayeur
The impact of sex and age on neurological outcomes in out-of-hospital cardiac arrest patients with targeted temperature management
Sang Hoon Oh, Kyu Nam Park, Jeeyong Lim, Seung Pill Choi, Joo Suk Oh, In Soo Cho, Byung Kook Lee, Yong Hwan Kim, Young-Min Kim, Han Joon Kim, Chun Song Youn, Soo Hyun Kim
Early psychological screening of intensive care unit survivors: a prospective cohort study
Anna Milton, Emily Brück, Anna Schandl, Matteo Bottai, Peter Sackey
Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia
Birgitt Gutbier, Xiaohui Jiang, Kristina Dietert, Carolin Ehrler, Jasmin Lienau, Paul Van Slyke, Harold Kim, Van C. Hoang, Jason T. Maynes, Daniel J. Dumont, Achim D. Gruber, Norbert Weissmann, Timothy J. Mitchell, Norbert Suttorp, Martin Witzenrath
An isolated elevation in blood urea level is not ‘uraemia’ and not an indication for renal replacement therapy in the ICU
Jack Mackenzie, Bobby Chacko
Cefepime-induced neurotoxicity: a systematic review
Lauren E. Payne, David J. Gagnon, Richard R. Riker, David B. Seder, Elizabeth K. Glisic, Jane G. Morris, Gilles L. Fraser
Angiotensin II in vasodilatory shock: lights and shadows
Elio Antonucci, Sara Agosta, Yasser Sakr
Weekend effect: a great problem with a potential solution
Ana Abella, Beatriz Lobo-Valbuena, Marcela Hómez, Federico Gordo
Pearls and pitfalls in comprehensive critical care echocardiography
Sam Orde, Michel Slama, Andrew Hilton, Konstantin Yastrebov, Anthony McLean
Kinetic estimated glomerular filtration rate in critically ill patients: beyond the acute kidney injury severity classification system
Flávio de Oliveira Marques, Saulo Aires Oliveira, Priscila Ferreira de Lima e Souza, Wandervânia Gomes Nojoza, Maiara da Silva Sena, Taynara Muniz Ferreira, Bruno Gabriele Costa, Alexandre Braga Libório
Complications of regional citrate anticoagulation: accumulation or overload?
Antoine G. Schneider, Didier Journois, Thomas Rimmelé
A clinical prediction model to identify patients at high risk of hemodynamic instability in the pediatric intensive care unit
Cristhian Potes, Bryan Conroy, Minnan Xu-Wilson, Christopher Newth, David Inwald, Joseph Frassica
Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections
Mohd H. Abdul-Aziz, Jeffrey Lipman, Jason A. Roberts
Impact of earplugs and eye mask on sleep in critically ill patients: a prospective randomized study
Alexandre Demoule, Serge Carreira, Sophie Lavault, Olivier Pallanca, Elise Morawiec, Julien Mayaux, Isabelle Arnulf, Thomas Similowski
High-flow nasal cannula versus noninvasive positive pressure ventilation in acute respiratory failure: interaction between PaO2/FiO2 and tidal volume
Yanfei Shen, Weimin Zhang
Vitamin D deficiency in critically ill children: a systematic review and meta-analysis
James Dayre McNally, Nassr Nama, Katie O’Hearn, Margaret Sampson, Karin Amrein, Klevis Iliriani, Lauralyn McIntyre, Dean Fergusson, Kusum Menon
Video laryngoscopy does not improve the intubation outcomes in emergency and critical patients – a systematic review and meta-analysis of randomized controlled trials
Jia Jiang, Danxu Ma, Bo Li, Yun Yue, Fushan Xue
High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial
Kevin K. Chung, Elsa C. Coates, David J. Smith Jr, Rachel A. Karlnoski, William L. Hickerson, Angela L. Arnold-Ross, Michael J. Mosier, Marcia Halerz, Amy M. Sprague, Robert F. Mullins, Daniel M. Caruso, Marlene Albrecht, Brett D. Arnoldo, Agnes M. Burris, Sandra L. Taylor, Steven E. Wolf, Booker T. King, Julie A. Rizzo, Jeremy C. Pamplin, Ian R. Driscoll, Evan M. Renz, Jonathan B. Lundy, Leopoldo C. Cancio, Carl W. Cruse, Christopher A. McFarren, Kimberly S. Brown, Arif Showkat, Lekha George, Aneel Kumar, Barbara Birmingham, David Hill, Mary E. Bruce, Arthur P. Sanford, David J. Leehey, Robert F. Mullins, Zaheed Hassan, Joseph R. Shaver, Bruce Friedman, Kevin N. Fosters, Michael D. Peck, Herb A. Phelan, Ramesh Saxena, James Howard, Dhaval Bhavsar, Satish Ponnuru, Michelle DeSouza, Sri G. Yarlagadda
Chloral hydrate enteral infusion for sedation in ventilated children: the CHOSEN pilot study
Ari R. Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P. Duff, Gonzalo Garcia Guerra
Iatrogenic hemodilution: a possible cause for avoidable blood transfusions?
Azriel Perel
Longitudinal wall fractional shortening: an M-mode index based on mitral annular plane systolic excursion (MAPSE) that correlates and predicts left ventricular longitudinal strain (LVLS) in intensive care patients
Stephen J. Huang, Iris Ting, Andrea M. Huang, Michel Slama, Anthony S. McLean
Initial nutritional management during noninvasive ventilation and outcomes: a retrospective cohort study
Nicolas Terzi, Michael Darmon, Jean Reignier, Stéphane Ruckly, Maïté Garrouste-Orgeas, Alexandre Lautrette, Elie Azoulay, Bruno Mourvillier, Laurent Argaud, Laurent Papazian, Marc Gainnier, Dan Goldgran-Toledano, Samir Jamali, Anne-Sylvie Dumenil, Carole Schwebel, Jean-François Timsit, Jean-François Timsit, Elie Azoulay, Maïté Garrouste-Orgeas, Jean-Ralph Zahar, Christophe Adrie, Michael Darmon, Christophe Clec’h, Jean-Francois Timsit, Corinne Alberti, Stephane Ruckly, Sébastien Bailly, Lenka Styfalova, Aurélien Vannieuwenhuyze, Christophe Adrie, Bernard Allaouchiche, Laurent Argaud, Claire Ara-Somohano, Elie Azoulay, Francois Barbier, Julien Bohé, Christine Cheval, Christophe Clec’h, Michael Darmon, Anne-Sylvie Dumenil, Claire Dupuis, Jean-Marie Forel, Marc Gainier, Akim Haouache, Samir Jamali, Hatem Khallel, Alexandre Lautrette, Guillaume Marcotte, Eric Le Miere, Maxime Lugosi, Bruno Mourvillier, Benoît Misset, Delphine Moreau, Bruno Mourvillier, Laurent Papazian, Benjamin Planquette, Bertrand Souweine, Carole Schwebel, Nicolas Terzi, Gilles Troché, Marie Thuong, Guillaume Thierry, Dany Toledano, Eric Vantalon, Julien Fournier, Caroline Tournegros, Stéphanie Bagur, Mireille Adda, Vanessa Vindrieux, Loic Ferrand, Nadira Kaddour, Boris Berthe, Samir Bekkhouche, Kaouttar Mellouk, Sylvie Conrozier, Igor Theodose, Veronique Deiler, Sophie Letrou
Long-term continuous renal replacement therapy and anticoagulation with citrate in critically ill patients with severe liver dysfunction
Matthias Klingele, Theresa Stadler, Danilo Fliser, Timo Speer, Heinrich V. Groesdonk, Alexander Raddatz
Change in cardiac output during Trendelenburg maneuver is a reliable predictor of fluid responsiveness in patients with acute respiratory distress syndrome in the prone position under protective ventilation
Hodane Yonis, Laurent Bitker, Mylène Aublanc, Sophie Perinel Ragey, Zakaria Riad, Floriane Lissonde, Aurore Louf-Durier, Sophie Debord, Florent Gobert, Romain Tapponnier, Claude Guérin, Jean-Christophe Richard
Recovery after critical illness: putting the puzzle together—a consensus of 29
Elie Azoulay, Jean-Louis Vincent, Derek C. Angus, Yaseen M. Arabi, Laurent Brochard, Stephen J. Brett, Giuseppe Citerio, Deborah J. Cook, Jared Randall Curtis, Claudia C. dos Santos, E. Wesley Ely, Jesse Hall, Scott D. Halpern, Nicholas Hart, Ramona O. Hopkins, Theodore J. Iwashyna, Samir Jaber, Nicola Latronico, Sangeeta Mehta, Dale M. Needham, Judith Nelson, Kathleen Puntillo, Michael Quintel, Kathy Rowan, Gordon Rubenfeld, Greet Van den Berghe, Johannes Van der Hoeven, Hannah Wunsch, Margaret Herridge
Extracorporeal membrane oxygenation for life-threatening asthma refractory to mechanical ventilation: analysis of the Extracorporeal Life Support Organization registry
Hye Ju Yeo, Dohyung Kim, Doosoo Jeon, Yun Seong Kim, Peter Rycus, Woo Hyun Cho
A supplemental intravenous amino acid infusion sustains a positive protein balance for 24 hours in critically ill patients
Martin Sundström Rehal, Felix Liebau, Inga Tjäder, Åke Norberg, Olav Rooyackers, Jan Wernerman
A systematic approach to ultrasound-guided central venous catheter placement—desirable modifications
Ryszard Gawda, Tomasz Czarnik
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
Anitra C. Carr, Patrice C. Rosengrave, Simone Bayer, Steve Chambers, Jan Mehrtens, Geoff M. Shaw
Comparison of mortality prediction models in acute respiratory distress syndrome undergoing extracorporeal membrane oxygenation and development of a novel prediction score: the PREdiction of Survival on ECMO Therapy-Score (PRESET-Score)
Michael Hilder, Frank Herbstreit, Michael Adamzik, Martin Beiderlinden, Markus Bürschen, Jürgen Peters, Ulrich H. Frey
Microvascular effects of intravenous esmolol in patients with normal cardiac function undergoing postoperative atrial fibrillation: a prospective pilot study in cardiothoracic surgery
William Fornier, Matthias Jacquet-Lagrèze, Thomas Collenot, Priscilla Teixeira, Philippe Portran, Rémi Schweizer, Michel Ovize, Jean-Luc Fellahi
The term “supplemental parenteral nutrition” should be restricted to studies meeting specific technical criteria
Claude Pichard, Mette M. Berger
Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome
Anthony J. Esposito, Pavan K. Bhatraju, Renee D. Stapleton, Mark M. Wurfel, Carmen Mikacenic
Recombinant human ACE2: acing out angiotensin II in ARDS therapy
Haibo Zhang, Andrew Baker
The forgotten value of the clinical examination to individualize and guide fluid resuscitation in patients with sepsis
Gentle Sunder Shrestha, Martin Dünser, Mervyn Mer
Necessary additional steps in ultrasound guided central venous catheter placement: getting to the heart of the matter
Thei S. Steenvoorden, Jasper M. Smit, Mark E. Haaksma, Pieter R. Tuinman
Co-administration of vancomycin and piperacillin-tazobactam is associated with increased renal dysfunction in adult and pediatric burn patients
Gabriel Hundeshagen, David N. Herndon, Karel D. Capek, Ludwik K. Branski, Charles D. Voigt, Elizabeth A. Killion, Janos Cambiaso-Daniel, Michaela Sljivich, Andrew De Crescenzo, Ronald P. Mlcak, Michael P. Kinsky, Celeste C. Finnerty, William B. Norbury
Antimicrobials for the treatment of drug-resistant Acinetobacter baumannii pneumonia in critically ill patients: a systemic review and Bayesian network meta-analysis
Su Young Jung, Seung Hee Lee, Soo Young Lee, Seungwon Yang, Hayeon Noh, Eun Kyoung Chung, Jangik I. Lee
Comparison of the efficacy of three topical antiseptic solutions for the prevention of catheter colonization: a multicenter randomized controlled study
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