Diabetologia

Up front May 2016

Adipose tissue macrophages: going off track during obesity

Lily Boutens, Rinke Stienstra

Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle

Taylor K. Soderborg, Sarah J. Borengasser, Linda A. Barbour, Jacob E. Friedman

Improved glucose regulation in type 2 diabetic patients with DPP-4 inhibitors: focus on alpha and beta cell function and lipid metabolism

Bo Ahrén, James E. Foley

Is leptin coming back? A short introduction to the presentations in this symposium session at the 2015 annual meeting of the EASD

Ulf Smith

Renaissance of leptin for obesity therapy

Carmelo Quarta, Miguel A. Sánchez-Garrido, Matthias H. Tschöp, Christoffer Clemmensen

The role of leptin in diabetes: metabolic effects

Thomas H. Meek, Gregory J. Morton

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis

Rachel J. Perry, Kitt Falk Petersen, Gerald I. Shulman

Insights into metabolic disease from studying genetics in isolated populations: stories from Greece to Greenland

Eleftheria Zeggini, Anna L. Gloyn, Torben Hansen

Bariatric surgery: traversing the CROSSROADS into mainstream diabetes care

Karl J. Neff, Carel W. le Roux

Gastric bypass surgery vs intensive lifestyle and medical intervention for type 2 diabetes: the CROSSROADS randomised controlled trial

David E. Cummings, David E. Arterburn, Emily O. Westbrook, Jessica N. Kuzma, Skye D. Stewart, Chun P. Chan, Steven N. Bock, Jeffrey T. Landers, Mario Kratz, Karen E. Foster-Schubert, David R. Flum

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial

Olivia M. Farr, Michail Sofopoulos, Michael A. Tsoukas, Fadime Dincer, Bindiya Thakkar, Ayse Sahin-Efe, Andreas Filippaios, Jennifer Bowers, Alexandra Srnka, Anna Gavrieli, Byung-Joon Ko, Chrysoula Liakou, Nickole Kanyuch, Sofia Tseleni-Balafouta, Christos S. Mantzoros

The insulinotropic effect of pulsatile compared with continuous intravenous delivery of GLP-1

Mark P. Plummer, Palash Kar, Caroline E. Cousins, Kylie Lange, Marianne J. Chapman, Michael A. Nauck, Michael Horowitz, Juris J. Meier, Adam M. Deane

First-trimester multimarker prediction of gestational diabetes mellitus using targeted mass spectrometry

Tina Ravnsborg, Lise Lotte T. Andersen, Natacha D. Trabjerg, Lars M. Rasmussen, Dorte M. Jensen, Martin Overgaard

Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals

Bendix Carstensen, Stephanie H Read, Søren Friis, Reijo Sund, Ilmo Keskimäki, Ann-Marie Svensson, Rickard Ljung, Sarah H Wild, Joannes J Kerssens, Jessica L Harding, Dianna J Magliano, Soffia Gudbjörnsdottir

Incidence of register-based diabetes 10 years after a stepwise diabetes screening programme: the ADDITION-Denmark study

Signe S. Rasmussen, Nanna B. Johansen, Daniel R. Witte, Knut Borch-Johnsen, Annelli Sandbaek, Torsten Lauritzen, Marit E. Jørgensen

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

Symen Ligthart, Rebecca V. Steenaard, Marjolein J. Peters, Joyce B. J. van Meurs, Eric J. G. Sijbrands, André G. Uitterlinden, Marc J. Bonder, Albert Hofman, Oscar H. Franco, Abbas Dehghan

The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice

Yusuf Ali, Juan Diez, Lars Selander, Xiaofeng Zheng, Helena Edlund, Per-Olof Berggren

Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis

Joan Mir-Coll, Jordi Duran, Felipe Slebe, Mar García-Rocha, Ramon Gomis, Rosa Gasa, Joan J. Guinovart

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice

Jinxiu Rui, Songyan Deng, Jasmin Lebastchi, Pamela L. Clark, Sahar Usmani-Brown, Kevan C. Herold

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity

Lauren M. Sparks, Anne Gemmink, Esther Phielix, Madeleen Bosma, Gert Schaart, Esther Moonen-Kornips, Johanna A. Jörgensen, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Patrick Schrauwen, Joris Hoeks

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans

Anne Gemmink, Madeleen Bosma, Helma J. H. Kuijpers, Joris Hoeks, Gert Schaart, Marc A. M. J. van Zandvoort, Patrick Schrauwen, Matthijs K. C. Hesselink

Exosome-like vesicles released from lipid-induced insulin-resistant muscles modulate gene expression and proliferation of beta recipient cells in mice

Audrey Jalabert, Guillaume Vial, Claudiane Guay, Oscar P. B. Wiklander, Joel Z. Nordin, Hala Aswad, Alexis Forterre, Emmanuelle Meugnier, Sandra Pesenti, Romano Regazzi, Emmanuelle Danty-Berger, Sylvie Ducreux, Hubert Vidal, Samir El-Andaloussi, Jennifer Rieusset, Sophie Rome

GLP-1 receptor agonist promotes brown remodelling in mouse white adipose tissue through SIRT1

Fen Xu, Beisi Lin, Xiaobin Zheng, Zonglan Chen, Huanyi Cao, Haixia Xu, Hua Liang, Jianping Weng

Insomnia does not mediate or modify the association between MTNR1B risk variant rs10830963 and glucose levels

Hanna M Ollila, Erkki Kronholm, Johannes Kettunen, Kaisa Silander, Markus Perola, Tarja Porkka-Heiskanen, Veikko Salomaa, Tiina Paunio