Diabetologia

Up front

Promises and pitfalls of electronic health record analysis

Ruth Farmer, Rohini Mathur, Krishnan Bhaskaran, Sophie V. Eastwood, Nish Chaturvedi, Liam Smeeth

Epidemiology of diabetes and diabetic complications in China

Ronald C. W. Ma

Extracellular matrix molecules and their potential contribution to the function of transplanted pancreatic islets

L. Alberto Llacua, Marijke M. Faas, Paul de Vos

Defining outcomes for beta cell replacement therapy: a work in progress

Lorenzo Piemonti, Eelco J. P. de Koning, Thierry Berney, Jon S. Odorico, James F. Markmann, Peter G. Stock, Michael R. Rickels

Can targeting ANGPTL proteins improve glucose tolerance?

Brandon S. J. Davies

Short-term decreased physical activity with increased sedentary behaviour causes metabolic derangements and altered body composition: effects in individuals with and without a first-degree relative with type 2 diabetes

Kelly A. Bowden Davies, Victoria S. Sprung, Juliette A. Norman, Andrew Thompson, Katie L. Mitchell, Jason C. G. Halford, Jo A. Harrold, John P. H. Wilding, Graham J. Kemp, Daniel J. Cuthbertson

Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

Caroline Honsek, Stefan Kabisch, Margrit Kemper, Christiana Gerbracht, Ayman M. Arafat, Andreas L. Birkenfeld, Ulrike Dambeck, Martin A. Osterhoff, Martin O. Weickert, Andreas F. H. Pfeiffer

Effect of screening for type 2 diabetes on healthcare costs: a register-based study among 139,075 individuals diagnosed with diabetes in Denmark between 2001 and 2009

Camilla Sortsø, Anastasija Komkova, Annelli Sandbæk, Simon J. Griffin, Martha Emneus, Torsten Lauritzen, Rebecca K. Simmons

Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose

Jordi Merino, Aaron Leong, Ching-Ti Liu, Bianca Porneala, Geoffrey A. Walford, Marcin von Grotthuss, Thomas J. Wang, Jason Flannick, Josée Dupuis, Daniel Levy, Robert E. Gerszten, Jose C. Florez, James B. Meigs

Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries

Sherly X. Li, Fumiaki Imamura, Matthias B. Schulze, Jusheng Zheng, Zheng Ye, Antonio Agudo, Eva Ardanaz, Dagfinn Aune, Heiner Boeing, Miren Dorronsoro, Courtney Dow, Guy Fagherazzi, Sara Grioni, Marc J. Gunter, José María Huerta, Daniel B. Ibsen, Marianne Uhre Jakobsen, Rudolf Kaaks, Timothy J. Key, Kay-Tee Khaw, Cecilie Kyrø, Francesca Romana Mancini, Elena Molina-Portillo, Neil Murphy, Peter M. Nilsson, N. Charlotte Onland-Moret, Domenico Palli, Salvatore Panico, Alaitz Poveda, J. Ramón Quirós, Fulvio Ricceri, Ivonne Sluijs, Annemieke M. W. Spijkerman, Anne Tjonneland, Rosario Tumino, Anna Winkvist, Claudia Langenberg, Stephen J. Sharp, Elio Riboli, Robert A. Scott, Nita G. Forouhi, Nicholas J. Wareham

Overweight, obesity and the risk of LADA: results from a Swedish case–control study and the Norwegian HUNT Study

Rebecka Hjort, Emma Ahlqvist, Per-Ola Carlsson, Valdemar Grill, Leif Groop, Mats Martinell, Bahareh Rasouli, Anders Rosengren, Tiinamaija Tuomi, Bjørn Olav Åsvold, Sofia Carlsson

Lp-PLA2 activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study

Moneeza K. Siddiqui, Gwen Kennedy, Fiona Carr, Alexander S. F. Doney, Ewan R. Pearson, Andrew D. Morris, Toby Johnson, Megan M. McLaughlin, Rachel E. Williams, Colin N. A. Palmer

Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry

Stefanie Lanzinger, Joachim Rosenbauer, Dorothea Sugiri, Tamara Schikowski, Birgit Treiber, Daniela Klee, Wolfgang Rathmann, Reinhard W. Holl

Distribution of IL-1β immunoreactive cells in pancreatic biopsies from living volunteers with new-onset type 1 diabetes: comparison with donors without diabetes and with longer duration of disease

Shiva Reddy, Lars Krogvold, Charlton Martin, Rebecca Holland, Jaimin Choi, Hannah Woo, Fiona Wu, Knut Dahl-Jørgensen

The resident macrophages in murine pancreatic islets are constantly probing their local environment, capturing beta cell granules and blood particles

Bernd H. Zinselmeyer, Anthony N. Vomund, Brian T. Saunders, Michael W. Johnson, Javier A. Carrero, Emil R. Unanue

Targeted delivery of antigen to intestinal dendritic cells induces oral tolerance and prevents autoimmune diabetes in NOD mice

Yulin Chen, Jie Wu, Jiajia Wang, Wenjing Zhang, Bohui Xu, Xiaojun Xu, Li Zong

B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model

Larissa C. Da Rosa, Joanne Boldison, Evy De Leenheer, Joanne Davies, Li Wen, F. Susan Wong

Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes

Cynthia M. F. Monaco, Meghan C. Hughes, Sofhia V. Ramos, Nina E. Varah, Christian Lamberz, Fasih A. Rahman, Chris McGlory, Mark A. Tarnopolsky, Matthew P. Krause, Robert Laham, Thomas J. Hawke, Christopher G. R. Perry

Ceramide stearic to palmitic acid ratio predicts incident diabetes

Mika Hilvo, Tuire Salonurmi, Aki S. Havulinna, Dimple Kauhanen, Eva Ringdal Pedersen, Grethe S. Tell, Klaus Meyer, Anna-Maria Teeriniemi, Tiina Laatikainen, Pekka Jousilahti, Markku J. Savolainen, Ottar Nygård, Veikko Salomaa, Reijo Laaksonen

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

Daniel F. Vatner, Leigh Goedeke, Joao-Paulo G. Camporez, Kun Lyu, Ali R. Nasiri, Dongyan Zhang, Sanjay Bhanot, Susan F. Murray, Christopher D. Still, Glenn S. Gerhard, Gerald I. Shulman, Varman T. Samuel

Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota

Aafke W. F. Janssen, Saeed Katiraei, Barbara Bartosinska, Daniel Eberhard, Ko Willems van Dijk, Sander Kersten

Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes

Thomas Laeger, Teresa Castaño-Martinez, Martin W. Werno, Lukasz Japtok, Christian Baumeier, Wenke Jonas, Burkhard Kleuser, Annette Schürmann

Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets

Isabel González-Mariscal, Rodrigo A. Montoro, Máire E. Doyle, Qing-Rong Liu, Michael Rouse, Jennifer F. O’Connell, Sara Santa-Cruz Calvo, Susan M. Krzysik-Walker, Soumita Ghosh, Olga D. Carlson, Elin Lehrmann, Yongqing Zhang, Kevin G. Becker, Chee W. Chia, Paritosh Ghosh, Josephine M. Egan

Characteristics of slow progression to diabetes in multiple islet autoantibody-positive individuals from five longitudinal cohorts: the SNAIL study

Anna E. Long, Isabel V. Wilson, Dorothy J. Becker, Ingrid M. Libman, Vincent C. Arena, F. Susan Wong, Andrea K. Steck, Marian J. Rewers, Liping Yu, Peter Achenbach, Rosaura Casas, Johnny Ludvigsson, Alistair J. K. Williams, Kathleen M. Gillespie

Correction to: Epidemiology of diabetes and diabetic complications in China

Ronald C. W. Ma