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Journal of Natural Medicines

Erschienen in:

01.10.2009 | Note

Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells

verfasst von: Yun Jung Lee, Sun Mi Hwang, Dae Gill Kang, Jin Sook Kim, Ho Sub Lee

Erschienen in: Journal of Natural Medicines | Ausgabe 4/2009

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Abstract

The aim of the present study was to investigate whether an ethanol extract of Gastrodia elata (EGE) rhizome, a traditional Korean herbal medical food, suppresses the endothelial extracellular matrix degradation induced by tumor necrosis factor (TNF)-α. Gelatin zymography results showed that pretreatment with EGE to human umbilical vein endothelial cells (HUVEC) decreased TNF-α-induced increase of matrix metalloproteinase (MMP)-2/-9 activities in the range of 1–50 μg/ml. Real-time qRT-PCR results also revealed that TNF-α-induced MMP-2/-9 mRNA expression levels were attenuated by pretreatment with EGE. These results provide new insights into the pathophysiological mechanisms for the anti-atherosclerotic properties of EGE in vascular diseases.

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Titel: Effect of Gastrodia elata on tumor necrosis factor-alpha-induced matrix metalloproteinase activity in endothelial cells
verfasst von: Yun Jung Lee
Sun Mi Hwang
Dae Gill Kang
Jin Sook Kim
Ho Sub Lee
Publikationsdatum: 01.10.2009
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 4/2009
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-009-0352-6

Springer Medizin

Abstract

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