Skip to main content
Erschienen in: Gastro-News 1/2017

12.10.2017 | Cisaprid | journal club

Beschwerden des oberen Gastrointestinaltrakts

Pathophysiologie, Diagnostik und Therapie bei funktioneller Dyspepsie

verfasst von: Prof. Dr. med. Martin Storr, MHBA, PD Dr. med. Constanze H. Waggershauser

Erschienen in: Gastro-News | Ausgabe 1/2017

Einloggen, um Zugang zu erhalten

Zusammenfassung

Funktionelle Beschwerden des oberen Gastrointestinaltraktes treten häufig auf und stellen für den Arzt eine Herausforderung dar. Die medikamentösen Maßnahmen sind durch die Indikationsbeschränkungen wichtiger Arzneimittel limitiert worden. Es besteht aber kein Grund für therapeutischen Nihilismus. Aufgrund des hohen Beratungsbedarfs und des Leidensdrucks der Patienten ist die Therapie zeitaufwendig, interdisziplinär, und erfordert viel Empathie.
Literatur
1.
Zurück zum Zitat Lacy BE, Weiser KT, Kennedy AT, Crowell MD, Talley NJ. Functional dyspepsia: the economic impact to patients. Alimentary pharmacology & therapeutics. 2013;38(2):170–7. Epub 2013/06/04.CrossRef Lacy BE, Weiser KT, Kennedy AT, Crowell MD, Talley NJ. Functional dyspepsia: the economic impact to patients. Alimentary pharmacology & therapeutics. 2013;38(2):170–7. Epub 2013/06/04.CrossRef
2.
Zurück zum Zitat Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5):1466–79. Epub 2006/05/09.CrossRefPubMed Tack J, Talley NJ, Camilleri M, Holtmann G, Hu P, Malagelada JR, et al. Functional gastroduodenal disorders. Gastroenterology. 2006;130(5):1466–79. Epub 2006/05/09.CrossRefPubMed
3.
Zurück zum Zitat Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal Disorders. Gastroenterology. 2016;150(6):1380–92. Epub 2016/05/06.CrossRefPubMed Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, et al. Gastroduodenal Disorders. Gastroenterology. 2016;150(6):1380–92. Epub 2016/05/06.CrossRefPubMed
4.
Zurück zum Zitat Zagari RM, Law GR, Fuccio L, Cennamo V, Gilthorpe MS, Forman D, et al. Epidemiology of functional dyspepsia and subgroups in the Italian general population: an endoscopic study. Gastroenterology. 2010;138(4):1302–11. Epub 2010/01/16.CrossRefPubMed Zagari RM, Law GR, Fuccio L, Cennamo V, Gilthorpe MS, Forman D, et al. Epidemiology of functional dyspepsia and subgroups in the Italian general population: an endoscopic study. Gastroenterology. 2010;138(4):1302–11. Epub 2010/01/16.CrossRefPubMed
5.
Zurück zum Zitat Min BH, Huh KC, Jung HK, Yoon YH, Choi KD, Song KH, et al. Prevalence of uninvestigated dyspepsia and gastroesophageal reflux disease in Korea: a population-based study using the Rome III criteria. Digestive diseases and sciences. 2014;59(11):2721–9. Epub 2014/06/14.CrossRefPubMed Min BH, Huh KC, Jung HK, Yoon YH, Choi KD, Song KH, et al. Prevalence of uninvestigated dyspepsia and gastroesophageal reflux disease in Korea: a population-based study using the Rome III criteria. Digestive diseases and sciences. 2014;59(11):2721–9. Epub 2014/06/14.CrossRefPubMed
6.
Zurück zum Zitat Tack J, Carbone F, Holvoet L, Vanheel H, Vanuytsel T, Vandenberghe A. The use of pictograms improves symptom evaluation by patients with functional dyspepsia. Alimentary pharmacology & therapeutics. 2014;40(5):523–30. Epub 2014/07/24. Tack J, Carbone F, Holvoet L, Vanheel H, Vanuytsel T, Vandenberghe A. The use of pictograms improves symptom evaluation by patients with functional dyspepsia. Alimentary pharmacology & therapeutics. 2014;40(5):523–30. Epub 2014/07/24.
7.
Zurück zum Zitat Ahlawat SK, Richard Locke G, Weaver AL, Farmer SA, Yawn BP, Talley NJ. Dyspepsia consulters and patterns of management: a population-based study. Alimentary pharmacology & therapeutics. 2005;22(3):251–9. Epub 2005/08/11.CrossRef Ahlawat SK, Richard Locke G, Weaver AL, Farmer SA, Yawn BP, Talley NJ. Dyspepsia consulters and patterns of management: a population-based study. Alimentary pharmacology & therapeutics. 2005;22(3):251–9. Epub 2005/08/11.CrossRef
8.
Zurück zum Zitat Fang YJ, Liou JM, Chen CC, Lee JY, Hsu YC, Chen MJ, et al. Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria. Gut. 2015;64(10):1517–28. Epub 2014/11/20.CrossRefPubMed Fang YJ, Liou JM, Chen CC, Lee JY, Hsu YC, Chen MJ, et al. Distinct aetiopathogenesis in subgroups of functional dyspepsia according to the Rome III criteria. Gut. 2015;64(10):1517–28. Epub 2014/11/20.CrossRefPubMed
9.
Zurück zum Zitat Pilichiewicz AN, Horowitz M, Holtmann GJ, Talley NJ, Feinle-Bisset C. Relationship between symptoms and dietary patterns in patients with functional dyspepsia. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2009;7(3):317–22. Epub 2008/10/22.CrossRef Pilichiewicz AN, Horowitz M, Holtmann GJ, Talley NJ, Feinle-Bisset C. Relationship between symptoms and dietary patterns in patients with functional dyspepsia. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2009;7(3):317–22. Epub 2008/10/22.CrossRef
10.
Zurück zum Zitat Keshteli AH, Feizi A, Esmaillzadeh A, Zaribaf F, Feinle-Bisset C, Talley NJ, et al. Patterns of dietary behaviours identified by latent class analysis are associated with chronic uninvestigated dyspepsia. The British journal of nutrition. 2015;113(5):803–12. Epub 2015/02/18.CrossRefPubMed Keshteli AH, Feizi A, Esmaillzadeh A, Zaribaf F, Feinle-Bisset C, Talley NJ, et al. Patterns of dietary behaviours identified by latent class analysis are associated with chronic uninvestigated dyspepsia. The British journal of nutrition. 2015;113(5):803–12. Epub 2015/02/18.CrossRefPubMed
11.
Zurück zum Zitat Tack J, Talley NJ. Functional dyspepsia—symptoms, definitions and validity of the Rome III criteria. Nature reviews Gastroenterology & hepatology. 2013;10(3):134–41. Epub 2013/02/13.CrossRef Tack J, Talley NJ. Functional dyspepsia—symptoms, definitions and validity of the Rome III criteria. Nature reviews Gastroenterology & hepatology. 2013;10(3):134–41. Epub 2013/02/13.CrossRef
12.
Zurück zum Zitat Rhee PL, Kim YH, Son HJ, Kim JJ, Koh KC, Paik SW, et al. The etiologic role of gastric hypersensitivity in functional dyspepsia in Korea. Journal of clinical gastroenterology. 1999;29(4):332–5. Epub 1999/12/22.CrossRefPubMed Rhee PL, Kim YH, Son HJ, Kim JJ, Koh KC, Paik SW, et al. The etiologic role of gastric hypersensitivity in functional dyspepsia in Korea. Journal of clinical gastroenterology. 1999;29(4):332–5. Epub 1999/12/22.CrossRefPubMed
13.
Zurück zum Zitat Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA, et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2007;5(10):1175–83. Epub 2007/08/10.CrossRef Talley NJ, Walker MM, Aro P, Ronkainen J, Storskrubb T, Hindley LA, et al. Non-ulcer dyspepsia and duodenal eosinophilia: an adult endoscopic population-based case-control study. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2007;5(10):1175–83. Epub 2007/08/10.CrossRef
14.
Zurück zum Zitat Mazzoleni LE, Sander GB, Francesconi CF, Mazzoleni F, Uchoa DM, De Bona LR, et al. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Archives of internal medicine. 2011;171(21):1929–36. Epub 2011/11/30.CrossRefPubMed Mazzoleni LE, Sander GB, Francesconi CF, Mazzoleni F, Uchoa DM, De Bona LR, et al. Helicobacter pylori eradication in functional dyspepsia: HEROES trial. Archives of internal medicine. 2011;171(21):1929–36. Epub 2011/11/30.CrossRefPubMed
15.
Zurück zum Zitat Moayyedi P, Deeks J, Talley NJ, Delaney B, Forman D. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. The American journal of gastroenterology. 2003;98(12):2621–6. Epub 2003/12/23.CrossRefPubMed Moayyedi P, Deeks J, Talley NJ, Delaney B, Forman D. An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews. The American journal of gastroenterology. 2003;98(12):2621–6. Epub 2003/12/23.CrossRefPubMed
16.
Zurück zum Zitat Futagami S, Itoh T, Sakamoto C. Systematic review with meta-analysis: post-infectious functional dyspepsia. Alimentary pharmacology & therapeutics. 2015;41(2):177–88. Epub 2014/10/29.CrossRef Futagami S, Itoh T, Sakamoto C. Systematic review with meta-analysis: post-infectious functional dyspepsia. Alimentary pharmacology & therapeutics. 2015;41(2):177–88. Epub 2014/10/29.CrossRef
17.
Zurück zum Zitat Aro P, Talley NJ, Ronkainen J, Storskrubb T, Vieth M, Johansson SE, et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology. 2009;137(1):94–100. Epub 2009/03/31.CrossRefPubMed Aro P, Talley NJ, Ronkainen J, Storskrubb T, Vieth M, Johansson SE, et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology. 2009;137(1):94–100. Epub 2009/03/31.CrossRefPubMed
18.
Zurück zum Zitat Aro P, Talley NJ, Johansson SE, Agreus L, Ronkainen J. Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study. Gastroenterology. 2015;148(5):928–37. Epub 2015/02/04.CrossRefPubMed Aro P, Talley NJ, Johansson SE, Agreus L, Ronkainen J. Anxiety Is Linked to New-Onset Dyspepsia in the Swedish Population: A 10-Year Follow-up Study. Gastroenterology. 2015;148(5):928–37. Epub 2015/02/04.CrossRefPubMed
19.
Zurück zum Zitat Empfehlungen zur Therapie bei Funktioneller Dyspepsie und Reizdarmsyndrom. 2. Auflage 2010. Arzneiverordnung in der Praxis, Band 37. Sonderheft 1 (Therapieempfehlungen) Juli 2010 Empfehlungen zur Therapie bei Funktioneller Dyspepsie und Reizdarmsyndrom. 2. Auflage 2010. Arzneiverordnung in der Praxis, Band 37. Sonderheft 1 (Therapieempfehlungen) Juli 2010
20.
Zurück zum Zitat Sarnelli G, D’Alessandro A, Pesce M, Palumbo I, Cuomo R. Genetic contribution to motility disorders of the upper gastrointestinal tract. World journal of gastrointestinal pathophysiology. 2013;4(4):65–73. Epub 2013/11/19.CrossRefPubMedPubMedCentral Sarnelli G, D’Alessandro A, Pesce M, Palumbo I, Cuomo R. Genetic contribution to motility disorders of the upper gastrointestinal tract. World journal of gastrointestinal pathophysiology. 2013;4(4):65–73. Epub 2013/11/19.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Brawman-Mintzer O, Durkalski V, Wu Q, Romagnuolo J, Fogel E, Tarnasky P, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. The American journal of gastroenterology. 2014;109(3):436–42. Epub 2014/01/22.CrossRefPubMedPubMedCentral Brawman-Mintzer O, Durkalski V, Wu Q, Romagnuolo J, Fogel E, Tarnasky P, et al. Psychosocial characteristics and pain burden of patients with suspected sphincter of Oddi dysfunction in the EPISOD multicenter trial. The American journal of gastroenterology. 2014;109(3):436–42. Epub 2014/01/22.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Orive M, Barrio I, Orive VM, Matellanes B, Padierna JA, Cabriada J, et al. A randomized controlled trial of a 10 week group psychotherapeutic treatment added to standard medical treatment in patients with functional dyspepsia. Journal of psychosomatic research. 2015;78(6):563–8. Epub 2015/03/21.CrossRefPubMed Orive M, Barrio I, Orive VM, Matellanes B, Padierna JA, Cabriada J, et al. A randomized controlled trial of a 10 week group psychotherapeutic treatment added to standard medical treatment in patients with functional dyspepsia. Journal of psychosomatic research. 2015;78(6):563–8. Epub 2015/03/21.CrossRefPubMed
23.
Zurück zum Zitat Chang JY, Locke GR, 3rd, McNally MA, Halder SL, Schleck CD, Zinsmeister AR, et al. Impact of functional gastrointestinal disorders on survival in the community. The American journal of gastroenterology. 2010;105(4):822–32. Epub 2010/02/18.CrossRefPubMedPubMedCentral Chang JY, Locke GR, 3rd, McNally MA, Halder SL, Schleck CD, Zinsmeister AR, et al. Impact of functional gastrointestinal disorders on survival in the community. The American journal of gastroenterology. 2010;105(4):822–32. Epub 2010/02/18.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, et al. Evidence-based clinical practice guidelines for functional dyspepsia. Journal of gastroenterology. 2015;50(2):125–39. Epub 2015/01/15.CrossRefPubMed Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T, et al. Evidence-based clinical practice guidelines for functional dyspepsia. Journal of gastroenterology. 2015;50(2):125–39. Epub 2015/01/15.CrossRefPubMed
25.
Zurück zum Zitat Fischbach W, Malfertheiner P, Lynen Jansen P, Bolten W, Bornschein J, Buderus S, et al. [S2k-guideline Helicobacter pylori and gastroduodenal ulcer disease]. Zeitschrift fur Gastroenterologie. 2016;54(4):327–63. Epub 2016/08/12. S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit.CrossRefPubMed Fischbach W, Malfertheiner P, Lynen Jansen P, Bolten W, Bornschein J, Buderus S, et al. [S2k-guideline Helicobacter pylori and gastroduodenal ulcer disease]. Zeitschrift fur Gastroenterologie. 2016;54(4):327–63. Epub 2016/08/12. S2k-Leitlinie Helicobacter pylori und gastroduodenale Ulkuskrankheit.CrossRefPubMed
26.
Zurück zum Zitat Zhao B, Zhao J, Cheng WF, Shi WJ, Liu W, Pan XL, et al. Efficacy of Helicobacter pylori eradication therapy on functional dyspepsia: a meta-analysis of randomized controlled studies with 12-month follow-up. Journal of clinical gastroenterology. 2014;48(3):241–7. Epub 2013/09/05.CrossRefPubMed Zhao B, Zhao J, Cheng WF, Shi WJ, Liu W, Pan XL, et al. Efficacy of Helicobacter pylori eradication therapy on functional dyspepsia: a meta-analysis of randomized controlled studies with 12-month follow-up. Journal of clinical gastroenterology. 2014;48(3):241–7. Epub 2013/09/05.CrossRefPubMed
27.
Zurück zum Zitat Ford AC, Moayyedi P. Managing dyspepsia. Current gastroenterology reports. 2009;11(4):288–94. Epub 2009/07/21.CrossRefPubMed Ford AC, Moayyedi P. Managing dyspepsia. Current gastroenterology reports. 2009;11(4):288–94. Epub 2009/07/21.CrossRefPubMed
28.
Zurück zum Zitat Talley NJ. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology. 2005;129(5):1753–5. Epub 2005/11/16.CrossRefPubMed Talley NJ. American Gastroenterological Association medical position statement: evaluation of dyspepsia. Gastroenterology. 2005;129(5):1753–5. Epub 2005/11/16.CrossRefPubMed
29.
Zurück zum Zitat Ford AC, Moayyedi P, Jarbol DE, Logan RF, Delaney BC. Meta-analysis: Helicobacter pylori’test and treat’ compared with empirical acid suppression for managing dyspepsia. Alimentary pharmacology & therapeutics. 2008;28(5):534–44. Epub 2008/07/12.CrossRef Ford AC, Moayyedi P, Jarbol DE, Logan RF, Delaney BC. Meta-analysis: Helicobacter pylori’test and treat’ compared with empirical acid suppression for managing dyspepsia. Alimentary pharmacology & therapeutics. 2008;28(5):534–44. Epub 2008/07/12.CrossRef
30.
Zurück zum Zitat Lacy BE, Talley NJ, Locke GR, 3rd, Bouras EP, DiBaise JK, El-Serag HB, et al. Review article: current treatment options and management of functional dyspepsia. Alimentary pharmacology & therapeutics. 2012;36(1):3–15. Epub 2012/05/18.CrossRef Lacy BE, Talley NJ, Locke GR, 3rd, Bouras EP, DiBaise JK, El-Serag HB, et al. Review article: current treatment options and management of functional dyspepsia. Alimentary pharmacology & therapeutics. 2012;36(1):3–15. Epub 2012/05/18.CrossRef
31.
Zurück zum Zitat von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P. STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study. The American journal of gastroenterology. 2007;102(6):1268–75. Epub 2007/05/29.CrossRef von Arnim U, Peitz U, Vinson B, Gundermann KJ, Malfertheiner P. STW 5, a phytopharmacon for patients with functional dyspepsia: results of a multicenter, placebo-controlled double-blind study. The American journal of gastroenterology. 2007;102(6):1268–75. Epub 2007/05/29.CrossRef
32.
Zurück zum Zitat Melzer J, Rosch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Alimentary pharmacology & therapeutics. 2004;20(11-12):1279–87. Epub 2004/12/21.CrossRef Melzer J, Rosch W, Reichling J, Brignoli R, Saller R. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Alimentary pharmacology & therapeutics. 2004;20(11-12):1279–87. Epub 2004/12/21.CrossRef
33.
Zurück zum Zitat Rosch W, Vinson B, Sassin I. A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia. Zeitschrift fur Gastroenterologie. 2002;40(6):401–8. Epub 2002/06/11.CrossRefPubMed Rosch W, Vinson B, Sassin I. A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia. Zeitschrift fur Gastroenterologie. 2002;40(6):401–8. Epub 2002/06/11.CrossRefPubMed
34.
Zurück zum Zitat Holtmann G, Gschossmann J, Mayr P, Talley NJ. A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia. Alimentary pharmacology & therapeutics. 2002;16(9):1641–8. Epub 2002/08/29.CrossRef Holtmann G, Gschossmann J, Mayr P, Talley NJ. A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia. Alimentary pharmacology & therapeutics. 2002;16(9):1641–8. Epub 2002/08/29.CrossRef
35.
Zurück zum Zitat Giacosa A, Guido D, Grassi M, Riva A, Morazzoni P, Bombardelli E, et al. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-based complementary and alternative medicine: eCAM. 2015;2015:915087. Epub 2015/05/09.CrossRef Giacosa A, Guido D, Grassi M, Riva A, Morazzoni P, Bombardelli E, et al. The Effect of Ginger (Zingiber officinalis) and Artichoke (Cynara cardunculus) Extract Supplementation on Functional Dyspepsia: A Randomised, Double-Blind, and Placebo-Controlled Clinical Trial. Evidence-based complementary and alternative medicine: eCAM. 2015;2015:915087. Epub 2015/05/09.CrossRef
36.
Zurück zum Zitat Suzuki H, Matsuzaki J, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, et al. Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia—a multicenter, double-blind, randomized, placebo-controlled study. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2014;26(7):950–61. Epub 2014/04/29.CrossRef Suzuki H, Matsuzaki J, Fukushima Y, Suzaki F, Kasugai K, Nishizawa T, et al. Randomized clinical trial: rikkunshito in the treatment of functional dyspepsia—a multicenter, double-blind, randomized, placebo-controlled study. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2014;26(7):950–61. Epub 2014/04/29.CrossRef
37.
Zurück zum Zitat Malfertheiner P, Holtmann G, Peitz U, Birkner B, Arnold R, Hotz J, et al. [Guidelines of the German Society of Digestive and Metabolic Diseases for treatment of dyspepsia]. Zeitschrift fur Gastroenterologie. 2001;39(11):937–56. Epub 2002/01/05. Leitlinien der Deutschen Gesellschaft fur Verdauungs- und Stoffwechselkrankheiten zur Behandlung der Dyspepsie.CrossRefPubMed Malfertheiner P, Holtmann G, Peitz U, Birkner B, Arnold R, Hotz J, et al. [Guidelines of the German Society of Digestive and Metabolic Diseases for treatment of dyspepsia]. Zeitschrift fur Gastroenterologie. 2001;39(11):937–56. Epub 2002/01/05. Leitlinien der Deutschen Gesellschaft fur Verdauungs- und Stoffwechselkrankheiten zur Behandlung der Dyspepsie.CrossRefPubMed
38.
Zurück zum Zitat Holtmann G, Talley NJ. Herbal medicines for the treatment of functional and inflammatory bowel disorders. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2015;13(3):422–32. Epub 2014/03/29.CrossRef Holtmann G, Talley NJ. Herbal medicines for the treatment of functional and inflammatory bowel disorders. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2015;13(3):422–32. Epub 2014/03/29.CrossRef
39.
Zurück zum Zitat Holtmann G, Gschossmann J, Karaus M, Fischer T, Becker B, Mayr P, et al. Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia. Alimentary pharmacology & therapeutics. 1999;13(11):1459–65. Epub 1999/11/26.CrossRef Holtmann G, Gschossmann J, Karaus M, Fischer T, Becker B, Mayr P, et al. Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia. Alimentary pharmacology & therapeutics. 1999;13(11):1459–65. Epub 1999/11/26.CrossRef
40.
Zurück zum Zitat Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, et al. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology. 2015;149(2):340–9 e2. Epub 2015/04/30.CrossRefPubMedPubMedCentral Talley NJ, Locke GR, Saito YA, Almazar AE, Bouras EP, Howden CW, et al. Effect of Amitriptyline and Escitalopram on Functional Dyspepsia: A Multicenter, Randomized Controlled Study. Gastroenterology. 2015;149(2):340–9 e2. Epub 2015/04/30.CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Vanheel H, Tack J. Therapeutic options for functional dyspepsia. Dig Dis. 2014;32(3):230–4. Epub 2014/04/16.CrossRefPubMed Vanheel H, Tack J. Therapeutic options for functional dyspepsia. Dig Dis. 2014;32(3):230–4. Epub 2014/04/16.CrossRefPubMed
42.
Zurück zum Zitat Tack J, Ly HG, Carbone F, Vanheel H, Vanuytsel T, Holvoet L, et al. Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2016;14(3):385–92 e4. Epub 2015/11/06.CrossRef Tack J, Ly HG, Carbone F, Vanheel H, Vanuytsel T, Holvoet L, et al. Efficacy of Mirtazapine in Patients With Functional Dyspepsia and Weight Loss. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2016;14(3):385–92 e4. Epub 2015/11/06.CrossRef
43.
Zurück zum Zitat Haag S, Senf W, Tagay S, Langkafel M, Braun-Lang U, Pietsch A, et al. Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy? Alimentary pharmacology & therapeutics. 2007;25(8):973–86. Epub 2007/04/04.CrossRef Haag S, Senf W, Tagay S, Langkafel M, Braun-Lang U, Pietsch A, et al. Is there a benefit from intensified medical and psychological interventions in patients with functional dyspepsia not responding to conventional therapy? Alimentary pharmacology & therapeutics. 2007;25(8):973–86. Epub 2007/04/04.CrossRef
44.
Zurück zum Zitat Zhou W, Su J, Zhang H. Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis. J Altern Complement Med. 2016;22(5):380–9. Epub 2016/03/31.CrossRefPubMed Zhou W, Su J, Zhang H. Efficacy and Safety of Acupuncture for the Treatment of Functional Dyspepsia: Meta-Analysis. J Altern Complement Med. 2016;22(5):380–9. Epub 2016/03/31.CrossRefPubMed
45.
Zurück zum Zitat Kusunoki H, Haruma K, Manabe N, Imamura H, Kamada T, Shiotani A, et al. Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2012;24(6):540–5, e250-1. Epub 2012/03/06.CrossRef Kusunoki H, Haruma K, Manabe N, Imamura H, Kamada T, Shiotani A, et al. Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society. 2012;24(6):540–5, e250-1. Epub 2012/03/06.CrossRef
46.
Zurück zum Zitat Tack J, Janssen P, Masaoka T, Farre R, Van Oudenhove L. Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2012;10(11):1239–45. Epub 2012/07/21.CrossRef Tack J, Janssen P, Masaoka T, Farre R, Van Oudenhove L. Efficacy of buspirone, a fundus-relaxing drug, in patients with functional dyspepsia. Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association. 2012;10(11):1239–45. Epub 2012/07/21.CrossRef
47.
Zurück zum Zitat Miwa H, Nagahara A, Tominaga K, Yokoyama T, Sawada Y, Inoue K, et al. Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. The American journal of gastroenterology. 2009;104(11):2779–87. Epub 2009/07/30.CrossRefPubMed Miwa H, Nagahara A, Tominaga K, Yokoyama T, Sawada Y, Inoue K, et al. Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial. The American journal of gastroenterology. 2009;104(11):2779–87. Epub 2009/07/30.CrossRefPubMed
Metadaten
Titel
Beschwerden des oberen Gastrointestinaltrakts
Pathophysiologie, Diagnostik und Therapie bei funktioneller Dyspepsie
verfasst von
Prof. Dr. med. Martin Storr, MHBA
PD Dr. med. Constanze H. Waggershauser
Publikationsdatum
12.10.2017
Verlag
Springer Medizin
Schlagwort
Cisaprid
Erschienen in
Gastro-News / Ausgabe 1/2017
Print ISSN: 1869-1005
Elektronische ISSN: 2520-8667
DOI
https://doi.org/10.1007/s15036-017-0234-9

Weitere Artikel der Ausgabe 1/2017

Gastro-News 1/2017 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.