Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
European Child & Adolescent Psychiatry
Erschienen in: European Child & Adolescent Psychiatry 4/2013

01.04.2013 | Review

How effective are drug treatments for children with ADHD at improving on-task behaviour and academic achievement in the school classroom? A systematic review and meta-analysis

verfasst von: Vibhore Prasad, Ellen Brogan, Caroline Mulvaney, Matthew Grainge, Wendy Stanton, Kapil Sayal

Erschienen in: European Child & Adolescent Psychiatry | Ausgabe 4/2013

Einloggen, um Zugang zu erhalten

Abstract

Attention-deficit hyperactivity disorder (ADHD) has a significant impact on children’s classroom behaviour, daily functioning and experience of school life. However, the effects of drug treatment for ADHD on learning and academic achievement are not fully understood. This review was undertaken to describe the effects of methylphenidate, dexamfetamine, mixed amfetamine salts and atomoxetine on children’s on-task behaviour and their academic performance, and to perform a meta-analysis to quantify these effects. Nine electronic databases were systematically searched for randomized controlled trials comparing drug treatment for ADHD against (i) no drug treatment, (ii) baseline (in crossover trials), or (iii) placebo; reporting outcomes encompassing measures of educational achievement within the classroom environment. Forty-three studies involving a pooled total of 2,110 participants were identified for inclusion. Drug treatment benefited children in the amount of school work that they completed, by up to 15 %, and less consistently improved children’s accuracy in specific types of academic assignments, such as arithmetic. Similar improvements were seen in classroom behaviour, with up to 14 % more of children’s time spent “on task”. Methylphenidate, dexamfetamine and mixed amfetamine formulations all showed beneficial effects on children’s on-task behaviour and academic work completion. Atomoxetine was examined in two studies, and was found to have no significant effect. These review findings suggest that medication for ADHD has the potential to improve children’s learning and academic achievement.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
The MTA Cooperative Group (1999) A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry 56(12):1073–1086CrossRef
2.
Polanczyk G, Silva de Lima M, Horta BL, Biederman J, Rohde LA (2007) The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 164(6):942–948PubMedCrossRef
3.
Taylor E et al (2004) European clinical guidelines for hyperkinetic disorder—first upgrade. Eur Child Adolesc Psychiatry 13(Suppl 1):I7–I30PubMed
4.
American Psychiatric Association (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC
5.
DuPaul GJ, Stoner G (2003) ADHD in the schools: assessment and intervention strategies, 2nd edn. Guilford Press, New York
6.
Fergusson DM et al (1997) Attentional difficulties in middle childhood and psychosocial outcomes in young adulthood. J Child Psychol Psychiatry 38(6):633–644PubMedCrossRef
7.
Klassen AF et al (2004) Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder. Pediatrics 114:e541PubMedCrossRef
8.
Harpin VA (2005) The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 90(Suppl I):i2–i7PubMedCrossRef
9.
Barkley RA (2002) Major life activity and health outcomes associated with attention-deficit/hyperactivity disorder. J Clin Psychiatry 63(Suppl 12):10–15PubMed
10.
Manuzza S et al (1998) Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry 155:4
11.
Frazier TW et al (2007) ADHD and achievement : meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil 40:49PubMedCrossRef
12.
Biederman J et al (2012) An examination of the impact of ADHD on IQ: a large, controlled, family based analysis. Biol Psychiatry 71:1S–316S Abstract no. 773CrossRef
13.
Duric NS, Elgen IB (2011) Norwegian children and adolescents with ADHD—a retrospective clinical study: subtypes and comorbid conditions and aspects of cognitive performance and social skills. Adolesc Psychiatry 1:349–354
14.
Bridgett DJ, Walker ME (2006) Intellectual functioning in adults with ADHD: a meta-analytic examination of full scale IQ differences between adults with and without ADHD. Psychol Assess 18(1):1–14PubMedCrossRef
15.
Barry TD, Lyman RD, Klinger LG (2002) Academic underachievement and attention-deficit/hyperactivity disorder: the negative impact of symptom severity on school performance. J Sch Psychol 40(3):259–283CrossRef
16.
Loe IM, Feldman HM (2007) Academic and educational outcomes of children with ADHD. Ambul Pediatr 7(1):82–90PubMedCrossRef
17.
Massetti GM et al (2008) Academic achievement over 8 years among children who met modified criteria for attention-deficit/hyperactivity disorder at 4–6 years of age. J Abnorm Child Psychol 36(3):399–410PubMedCrossRef
18.
Polderman TJC, Boomsma D, Bartels M, Verhulst FC, Huizink AC (2010) A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatr Scand 122(4):271–284PubMedCrossRef
19.
Wigal SB, Wigal TL (2006) The laboratory school protocol: its origin, use, and new applications. J Atten Disord 10:92PubMedCrossRef
20.
National Institute for Health and Clinical Excellence (2008) Attention deficit hyperactivity disorder: Diagnosis and management of ADHD in children, young people and adults (National Clinical Practice Guideline Number 72) National Institute for Health and Clinical Excellence: London
21.
Swanson JM et al (1993) Effect of stimulant medication on children with attention deficit disorder: a “review of reviews”. Except Child 60(2):154–162
22.
Jadad AR et al (1999) Treatment of attention-deficit/hyperactivity disorder. Evid Rep Technol Assess 11(i–viii):1–341
23.
Schachar R et al (2002) Attention-deficit hyperactivity disorder: critical appraisal of extended treatment studies. Can J Psychiatry Revue Canadienne De Psychiatrie 47(4):337–348
24.
Backman J, Firestone P (1979) A review of psychopharmacological and behavioral approaches to the treatment of hyperactive children. Am J Orthopsychiatry 49(3):500–504PubMedCrossRef
25.
Carlson JS et al (2007) Methylphenidate, atomoxetine, and caffeine: a primer for school psychologists. J Appl Sch Psychol 24(1):127–146CrossRef
26.
Murray DW et al (2011) Effects of OROS methylphenidate on academic, behavioral, and cognitive tasks in children 9 to 12 years of age with attention-deficit/hyperactivity disorder. Clin Pediatr 50:308CrossRef
27.
Scheffler RM et al (2009) Positive association between attention-deficit/hyperactivity disorder medication use and academic achievement during elementary school. Pediatrics 123:1273PubMedCrossRef
28.
Hale JB et al (2011) Executive impairment determines ADHD medication response: implications for academic achievement. J Learn Disabil 44:196PubMedCrossRef
29.
Semrud-Clikeman M et al (2008) Executive functioning in children with attention-deficit/hyperactivity disorder: combined type with and without a stimulant medication history. Neuropsychology 22(3):329–340PubMedCrossRef
30.
Barkley RA, Murphy KR, Fischer M (2008) ADHD in adults: what the science says. Guilford Press, New York
31.
Biederman J et al (2006) Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychol Med 39:167–179CrossRef
32.
Molina BSG et al (2009) MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. J Am Acad Child Adolesc Psychiatry 48:5CrossRef
33.
Biederman J, Faraone SV (2006) The effects of attention-deficit/hyperactivity disorder on employment and household income. Medscape Gen Med 8(3):12
34.
The Cochrane Collaboration (2008) Cochrane handbook for systematic reviews of interventions version 5.0.1. Higgins JPT, GS (editors). The Cochrane Collaboration
35.
The Cochrane Collaboration (2008) Review Manager Version 5.0. The Nordic Cochrane Centre, Copenhagen
36.
Biederman J et al (2007) Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study. Biol Psychiatry 62(9):970–976PubMedCrossRef
37.
McCracken JT et al (2003) Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (ADDERALL XR), in children with ADHD. J Am Acad Child Adolesc Psychiatry 42(6):673–683PubMedCrossRef
38.
Pelham WE et al (1999) A comparison of morning-only and morning/late afternoon Adderall to morning-only, twice-daily, and three times-daily methylphenidate in children with attention-deficit/hyperactivity disorder. Pediatrics 104(6):1300–1311PubMedCrossRef
39.
Pelham WE et al (1999) A comparison of Ritalin and Adderall: efficacy and time-course in children with attention-deficit/hyperactivity disorder. Pediatrics 103(4):e43PubMedCrossRef
40.
Swanson JM et al (1998) Analog classroom assessment of Adderall in children with ADHD. J Am Acad Child Adolesc Psychiatry 37(5):519–526PubMedCrossRef
41.
Ajibola O, Clement PW (1995) Differential effects of methylphenidate and self-reinforcement on attention-deficit hyperactivity disorder. Behav Modif 19(2):211–233PubMedCrossRef
42.
Balthazor MJ, Wagner RK, Pelham WE (1991) The specificity of the effects of stimulant medication on classroom learning-related measures of cognitive processing for attention-deficit disorder children. J Abnorm Child Psychol 19(1):35–52PubMedCrossRef
43.
Barkley RA, Dupaul GJ, McMurray MB (1991) Attention-deficit disorder with and without hyperactivity—clinical response to 3 dose levels of methylphenidate. Pediatrics 87(4):519–531PubMed
44.
Brams M et al (2008) A randomized, double-blind, crossover study of once-daily dexmethylphenidate in children with attention-deficit hyperactivity disorder: rapid onset of effect. CNS Drugs 22(8):693–704PubMedCrossRef
45.
Carlson CL et al (1992) Single and combined effects of methlyphenidate and behavior—therapy on the classroom performance of children with attention-deficit hyperactivity disorder. J Abnorm Child Psychol 20(2):213–232PubMedCrossRef
46.
Chacko A et al (2005) Stimulant medication effects in a summer treatment program among young children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 44(3):249–257PubMedCrossRef
47.
Dopfner M et al (2004) Comparative efficacy of once-a-day extended-release methylphenidate, two-times-daily immediate-release methylphenidate, and placebo in a laboratory school setting. Eur Child Adolesc Psychiatry 13:I93–I101PubMed
48.
Douglas VI et al (1986) Short-term effects of methylphenidate on the cognitive, learning and academic-performance of children with attention-deficit disorder in the laboratory and the classroom. J Child Psychol Psychiatry 27(2):191–211PubMed
49.
Dupaul GJ, Rapport MD (1993) Does methylphenidate normalize the classroom performance of children with attention-deficit disorder? J Am Acad Child Adolesc Psychiatry 32(1):190–198PubMedCrossRef
50.
Elia J et al (1993) Classroom academic-performance—improvement with both methlyphendiate and dextroamphetamine in ADHD boys. J Child Psychol Psychiatry 34(5):785–804PubMedCrossRef
51.
Evans SW, Pelham WE (1991) Psychostimulant effects on academic and behavioral measures for ADHD junior-high school students in a lecture format classroom. J Abnorm Child Psychol 19(5):537–552PubMedCrossRef
52.
Evans SW et al (2001) Dose-response effects of methylphenidate on ecologically valid measures of academic performance and classroom behavior in adolescents with ADHD. Exp Clin Psychopharmacol 9(2):163–175PubMedCrossRef
53.
Fabiano GA et al (2007) The single and combined effects of multiple intensities of behavior modification and methylphenidate for children with attention deficit hyperactivity disorder in a classroom setting. Sch Psychol Rev 36(2):195–216
54.
Gorman EB et al (2006) Effects of methylphenidate on subtypes of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 45(7):808–816PubMedCrossRef
55.
James RS et al (2001) Double-blind, placebo-controlled study of single-dose amphetamine formulations in ADHD. J Am Acad Child Adolesc Psychiatry 40(11):1268–1276PubMedCrossRef
56.
McGough JJ et al (2006) A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHD. J Atten Disord 9(3):476–485PubMedCrossRef
57.
Pelham WE et al (1985) Methylphenidate and children with attention deficit disorder—dose effects on classroom academic and social behavior. Arch Gen Psychiatry 42(10):948–952PubMedCrossRef
58.
Pelham WE et al (1987) Sustained release and standard methlyphenidate effects on cognitive and social-behavior in children with attention-deficit disorder. Pediatrics 80(4):491–501PubMed
59.
Pelham WE et al (1990) Relative efficacy of long-acting stimulants on children with attention-deficit hyperactivity disorder—a comparison of standard methylphenidate, sustained-release methylphenidate, sustained-release dextroamphetamine, and pemoline. Pediatrics 86(2):226–237PubMed
60.
Pelham WE et al (1993) Separate and combined effects of methylphenidate and behavior-modification on boys with attention-deficit hyperactivity disorder in the classroom. J Consult Clin Psychol 61(3):506–515PubMedCrossRef
61.
Pelham WE Jr et al (2005) A dose-ranging study of a methylphenidate transdermal system in children with ADHD. J Am Acad Child Adolesc Psychiatry 44(6):522–529PubMedCrossRef
62.
Rapport MD et al (1985) Methylphenidate in hyperactive-children—differential effects of dose on academic, learning and social behavior. J Abnorm Child Psychol 13(2):227–243PubMedCrossRef
63.
Rapport MD et al (1994) Attention-deficit disorder and methylphenidate—normalization rates, clinical effectiveness, and response prediction in 76 children. J Am Acad Child Adolesc Psychiatry 33(6):882–893PubMedCrossRef
64.
Silva RR et al (2006) Efficacy and duration of effect of extended-release dexmethylphenidate versus placebo in schoolchildren with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 16(3):239–251PubMedCrossRef
65.
Tannock R et al (1989) Dose-response effects of methylphenidate on academic-performance and overt behavior in hyperactive children. Pediatrics 84(4):648–657PubMed
66.
Vyse SA, Rapport MD (1989) The effects of methylphenidate on learning in children with ADDH: the stimulus equivalence paradigm. J Consult Clin Psychol 57(3):425–435PubMedCrossRef
67.
Wigal SB et al (2009) A 13-hour laboratory school study of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder. Child Adolesc Psychiatry Mental Health 3:17CrossRef
68.
Silva R et al (2005) Efficacy of two long-acting methylphenidate formulations in children with attention-deficit/hyperactivity disorder in a laboratory classroom setting. J Child Adolesc Psychopharmacol 15(4):637–654PubMedCrossRef
69.
Swanson JM et al (2004) A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit/hyperactivity disorder in the laboratory school (The Comacs Study). Pediatrics 113(3 Part 1):e206–e216PubMedCrossRef
70.
Ballinger C, Varley C, Nolen P (1984) Effects of methylphenidate on reading in children with attention deficit disorder. Am J Psychiatry 141(12):1590–1593PubMed
71.
Klein RG (1991) Effects of high methylphenidate doses on the cognitive performance of hyperactive children. Bratisl Med J 92(11):534–539
72.
Pelham WE et al (1989) Comparative effects of methylphenidate on ADD girls and ADD boys. J Am Acad Child Adolesc Psychiatry 28(5):773–776PubMedCrossRef
73.
Rapport MD et al (1986) Comparing classroom and clinic measures of attention deficit disorder: differential, idiosyncratic, and dose-response effects of methylphenidate. J Consult Clin Psychol 54(3):334–341PubMedCrossRef
74.
Rapport MD et al (1987) Attention deficit disorder and methylphenidate: group and single-subject analyses of dose effects on attention in clinic and classroom settings. J Clin Child Psychol 16(4):329–338CrossRef
75.
Richardson E et al (1988) Effects of methylphenidate dosage in hyperactive reading-disabled children: II. Reading achievement. J Am Acad Child Adolesc Psychiatry 27(1):78–87PubMedCrossRef
76.
Worrall A (1993) Evaluating the effects of methylphenidate on the cognitive, behavioural and academic performance of A.D.D. children in the classroom. S Afr J Child Adolesc Mental Health 5(2):96–101CrossRef
77.
Brown RT et al (2006) Atomoxetine in the management of children with ADHD: effects on quality of life and school functioning. Clin Pediatr 45(9):819–827CrossRef
78.
Wietecha LA et al (2009) Atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 19:6CrossRef
79.
Swanson JM (1992) School-based assessments and interventions for ADD students. K.C. Publishing, Irvine
80.
Murray DW et al (2009) Psychometric properties of teacher SKAMP ratings from a community sample. Assessment 16(2):193–208PubMedCrossRef
Metadaten
Titel
How effective are drug treatments for children with ADHD at improving on-task behaviour and academic achievement in the school classroom? A systematic review and meta-analysis
verfasst von
Vibhore Prasad
Ellen Brogan
Caroline Mulvaney
Matthew Grainge
Wendy Stanton
Kapil Sayal
Publikationsdatum
01.04.2013
Verlag
Springer-Verlag
Erschienen in
European Child & Adolescent Psychiatry / Ausgabe 4/2013
Print ISSN: 1018-8827
Elektronische ISSN: 1435-165X
DOI
https://doi.org/10.1007/s00787-012-0346-x

Weitere Artikel der Ausgabe 4/2013

European Child & Adolescent Psychiatry 4/2013 Zur Ausgabe

Book Review

Trauma-informed practices with children and adolescents

ESCAP Communications

Child and adolescent psychiatry in Belgium and the Flemish association for child and adolescent psychiatry

Original Contribution

Comorbid anxiety and neurocognitive dysfunctions in children with ADHD

Original Contribution

The relationship between Asperger’s syndrome and schizophrenia in adolescence

Brief Report

Depression with psychotic features in a child with SLE: successful therapy with psychotropic medications—case report

Brief Report

Pervasive refusal syndrome among inpatient asylum-seeking children and adolescents: a follow-up study

Neu im Fachgebiet Psychiatrie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Antihypertensiva schützen auch alte Menschen noch vor Demenz

17.04.2024 | Delir nicht substanzbedingt | Nachrichten

Delir kann Demenz begünstigen

16.04.2024 | Störungen der Geschlechtsidentität | Nachrichten

Zunahme von Geschlechtsinkongruenz und -dysphorie registriert

12.04.2024 | Vitiligo | Nachrichten

Vitiligo: Prävalenz steigt und viele Erkrankte werden spät behandelt
weitere anzeigen

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen