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Investigational New Drugs

Ausgabe 6/2010

Inhalt (22 Artikel)

PRECLINICAL STUDIES

MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules

Zhixiang Zhang, Tao Meng, Jingxue He, Ming Li, Lin-Jiang Tong, Bing Xiong, Liping Lin, Jingkang Shen, Ze-Hong Miao, Jian Ding

PRECLINICAL STUDIES

NBBS isolated from Pygeum africanum bark exhibits androgen antagonistic activity, inhibits AR nuclear translocation and prostate cancer cell growth

Maria Papaioannou, Sonja Schleich, Daniela Roell, Undine Schubert, Tamzin Tanner, Frank Claessens, Rudolf Matusch, Aria Baniahmad

PRECLINICAL STUDIES

Scaling the time-course of myelosuppression from rats to patients with a semi-physiological model

Lena E. Friberg, Marie Sandström, Mats O. Karlsson

PRECLINICAL STUDIES

Synthesis, characterization and in vitro anti-tumor activities of novel 9-ethyl-9H-purine derivatives

Raghu Ningegowda, Amit Grover, Basappa, S. Ranjith, Kanchugarakoppal S. Rangappa, B. S. Priya, S. Nanjunda Swamy

PRECLINICAL STUDIES

Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells

Pay-Chin Leow, Quan Tian, Zhan-Yuin Ong, Zheng Yang, Pui-Lai Rachel Ee

PRECLINICAL STUDIES

DH9, a novel PPARγ agonist suppresses the proliferation of ADPKD epithelial cells: An association with an inhibition of β-catenin signaling

Moyan Liu, Lili Fu, Chunyan Liu, Xishan Xiong, Xiang Gao, Min Xiao, Houan Cai, Huimin Hu, Xueqi Wang, Changlin Mei

PRECLINICAL STUDIES

Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations

In Hae Park, Jin Young Kim, Jae In Jung, Ji-Youn Han

PRECLINICAL STUDIES

Antimetastatic activity of MONCPT in preclinical melanoma mice model

Xiao-Chun Yang, Chong-Xing Tu, Pei-Hua Luo, Hong Zhu, Di-Feng Zhu, Hong-Hai Wu, Xing-Lu Zhou, Wei Lu, Qiao-Jun He, Bo Yang

PRECLINICAL STUDIES

TAE226-mediated inhibition of focal adhesion kinase interferes with tumor angiogenesis and vasculogenesis

Alexander Schultze, Sebastian Decker, Jasmin Otten, Andrea Kristina Horst, Gabi Vohwinkel, Gunter Schuch, Carsten Bokemeyer, Sonja Loges, Walter Fiedler

PHASE I STUDIES

Phase I study of non-pegylated liposomal doxorubicin in combination with ifosfamide in adult patients with metastatic soft tissue sarcomas

Elisa Stroppa, Alexia Bertuzzi, Gabriele Di Comite, Chiara Mussi, Romano Fabio Lutman, Alfredo Barbato, Armando Santoro

PHASE I STUDIES

Justification of the starting dose as the main determinant of accrual time in dose-seeking oncology phase 1 trials

Nicolas Penel, Pierre Leblond, Amélie Lansiaux, Stéphanie Clisant, Eric Dansin, Antoine Adenis, Jacques Bonneterre

Open Access PHASE I STUDIES

Phase I clinical and pharmacokinetic study of sorafenib in combination with carboplatin and paclitaxel in patients with advanced non–small cell lung cancer

Isamu Okamoto, Masaki Miyazaki, Ryotaro Morinaga, Hiroyasu Kaneda, Shinya Ueda, Yoshikazu Hasegawa, Taroh Satoh, Akira Kawada, Masahiro Fukuoka, Koichi Fukino, Takahiko Tanigawa, Kazuhiko Nakagawa

PHASE II STUDIES

The epothilone B analogue ixabepilone in patients with advanced hepatobiliary cancers: a trial of the University of Chicago Phase II Consortium

Halla S. Nimeiri, Deepti A. Singh, Kristen Kasza, David A. Taber, Rafat H. Ansari, Everett E. Vokes, Hedy L. Kindler

PHASE II STUDIES

Phase II study of gemcitabine and carboplatin in metastatic breast cancers with prior exposure to anthracyclines and taxanes

Daniel Chan, Wee-Lee Yeo, Maricel Tiemsim Cordero, Chiung-Ing Wong, Benjamin Chuah, Ross Soo, Sing-Huang Tan, Siew-Eng Lim, Boon-Cher Goh, Soo-Chin Lee

PHASE II STUDIES

Phase I/II study of sunitinib malate in Japanese patients with gastrointestinal stromal tumor after failure of prior treatment with imatinib mesylate

Kuniaki Shirao, Toshirou Nishida, Toshihiko Doi, Yoshito Komatsu, Kei Muro, Yinhua Li, Eiji Ueda, Atsushi Ohtsu

SHORT REPORT

New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34+ cells

Maria Alessandra Santucci, Manuela Mancini, Valentina Corradi, Ilaria lacobucci, Giovanni Martinelli, Maurizio Botta, Silvia Schenone

SHORT REPORT

Reflex sympathetic dystrophy in patients with metastatic renal cell carcinoma treated with Everolimus

Christophe Massard, Karim Fizazi, Marine Gross-Goupil, Bernard Escudier

SHORT REPORT

Painful cervical esophageal erosion in a patient with advanced colorectal cancer treated with bevacizumab

Carlos Eduardo Paiva, Yara Cristina de Paiva Maia, Bianca Sakamoto Ribeiro Paiva, Mauro Masson Lerco

SHORT REPORT

Dysphonia induced by vascular endothelium growth factor/vascular endothelium growth factor receptor inhibitors

Dana M. Hartl, Charles Ferté, Yohann Loriot, Carlos Gomez Roca, Rastislav Bahleda, Cristian Moldovan, Olivier Mir, Jean-Charles Soria

SHORT REPORT

Complete remission of ovarian cancer induced intractable malignant ascites with intraperitoneal bevacizumab. Immunological observations and a literature review

Filippo Bellati, Chiara Napoletano, Ilary Ruscito, Maria Pastore, Milena Pernice, Morena Antonilli, Marianna Nuti, Pierluigi Benedetti Panici

Erratum

Erratum to: Antimetastatic activity of MONCPT in preclinical melanoma mice model

Xiao-Chun Yang, Chong-Xing Tu, Pei-Hua Luo, Hong Zhu, Di-Feng Zhu, Hong-Hai Wu, Xing-Lu Zhou, Wei Lu, Qiao-Jun He, Bo Yang

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