Ausgabe 1/2017
Inhalt (194 Artikel)
Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
Makoto Isono, Michèle J. Hoffmann, Maria Pinkerneil, Akinori Sato, Martin Michaelis, Jindrich Cinatl Jr., Günter Niegisch, Wolfgang A. Schulz
RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer
Houbao Zhu, Wang-Yang Xu, Zhiqiang Hu, Hongxin Zhang, Yan Shen, Shunyuan Lu, Chaochun Wei, Zhu-Gang Wang
Oleuropein enhances radiation sensitivity of nasopharyngeal carcinoma by downregulating PDRG1 through HIF1α-repressed microRNA-519d
Ting Xu, Dajiang Xiao
Nomogram integrating gene expression signatures with clinicopathological features to predict survival in operable NSCLC: a pooled analysis of 2164 patients
Jian Wu, Lizhi Zhou, Lixia Huang, Jincui Gu, Shaoli Li, Baomo Liu, Jinlun Feng, Yanbin Zhou
Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer
Jun Zhang, Zhongqiu Lin, Yali Gao, Tingting Yao
Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice
Zhikun Ma, Amanda B. Parris, Zhengzheng Xiao, Erin W. Howard, Stanley D. Kosanke, Xiaoshan Feng, Xiaohe Yang
Blockage of glycolysis by targeting PFKFB3 suppresses tumor growth and metastasis in head and neck squamous cell carcinoma
Hui-Min Li, Jie-Gang Yang, Zhuo-Jue Liu, Wei-Ming Wang, Zi-Li Yu, Jian-Gang Ren, Gang Chen, Wei Zhang, Jun Jia
FGF19/FGFR4 signaling contributes to the resistance of hepatocellular carcinoma to sorafenib
Lixia Gao, Xuli Wang, Yaoliang Tang, Shuang Huang, Chien-An Andy Hu, Yong Teng
Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness
Irene Ylivinkka, Harri Sihto, Olli Tynninen, Yizhou Hu, Aki Laakso, Riku Kivisaari, Pirjo Laakkonen, Jorma Keski-Oja, Marko Hyytiäinen
Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation
Su Yao, Fangping Xu, Yu Chen, Yan Ge, Fen Zhang, Huijie Huang, Li Li, Danyi Lin, Xinlan Luo, Jie Xu, Donglan Luo, Xiaolan Zhu, Yanhui Liu
Long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) promotes tumorigenesis and metastasis by targeting miR-199a/b-5p in hepatocellular carcinoma
Tian Lan, Weijie Ma, Zhenfei Hong, Long Wu, Xi Chen, Yufeng Yuan
CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma
Deng Huang, Li Cao, Shuguo Zheng
The Targeted SMAC Mimetic SW IV-134 is a strong enhancer of standard chemotherapy in pancreatic cancer
Yassar M. Hashim, Suwanna Vangveravong, Narendra V. Sankpal, Pratibha S. Binder, Jingxia Liu, S. Peter Goedegebuure, Robert H. Mach, Dirk Spitzer, William G. Hawkins
Pro-inflammation NF-κB signaling triggers a positive feedback via enhancing cholesterol accumulation in liver cancer cells
Mingyan He, Wenhui Zhang, Yinying Dong, Lishun Wang, Tingting Fang, Wenqing Tang, Bei Lv, Guanglang Chen, Biwei Yang, Peixin Huang, Jinglin Xia
MIF/CD74 axis is a target for novel therapies in colon carcinomatosis
Fabio Bozzi, Angela Mogavero, Luca Varinelli, Antonino Belfiore, Giacomo Manenti, Claudio Caccia, Chiara C. Volpi, Galina V. Beznoussenko, Massimo Milione, Valerio Leoni, Annunziata Gloghini, Alexandre A. Mironov, Ermanno Leo, Silvana Pilotti, Marco A. Pierotti, Italia Bongarzone, Manuela Gariboldi
Regulation of TRIM24 by miR-511 modulates cell proliferation in gastric cancer
Ziling Fang, Ling Zhang, Quan Liao, Yi Wang, Feng Yu, Miao Feng, Xiaojun Xiang, Jianping Xiong
Erratum to: A panel of four genes accurately differentiates benign from malignant thyroid nodules
Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Quan Li, Yi-Xiang Jin, Wen-Xu Jin, Ying-Hao Wang, Zhou-Ci Zheng, Lu Xue, Ou-Chen Wang, Xiao-Hua Zhang
Resveratrol reverses Doxorubicin resistance by inhibiting epithelial-mesenchymal transition (EMT) through modulating PTEN/Akt signaling pathway in gastric cancer
Jiahui Xu, Deying Liu, Huilin Niu, Guifang Zhu, Yangwei Xu, Danli Ye, Jian Li, Qingling Zhang
HERV-K activation is strictly required to sustain CD133+ melanoma cells with stemness features
Ayele Argaw-Denboba, Emanuela Balestrieri, Annalucia Serafino, Chiara Cipriani, Ilaria Bucci, Roberta Sorrentino, Ilaria Sciamanna, Alessandra Gambacurta, Paola Sinibaldi-Vallebona, Claudia Matteucci
CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling
Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang, Yan Mei, Yuan-Yuan Qiang, Zi-Meng Zhang, Jing-Ping Yun, Bi-Jun Huang, Chao-Nan Qian
Disulfiram overcomes bortezomib and cytarabine resistance in Down-syndrome-associated acute myeloid leukemia cells
Ranjan Bista, David W. Lee, Oliver B. Pepper, David O. Azorsa, Robert J. Arceci, Eiman Aleem
Aberrant activation of hedgehog signaling promotes cell proliferation via the transcriptional activation of forkhead Box M1 in colorectal cancer cells
DeJie Wang, Guohui Hu, Ying Du, Cheng Zhang, Quqin Lu, Nonghua Lv, Shiwen Luo
Intracellular pH-responsive and rituximab-conjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells
Shoubing Zhou, Dan Wu, Xiaodong Yin, Xiaoxiao Jin, Xiu Zhang, Shiya Zheng, Cailian Wang, Yanwen Liu
Regulation of submaxillary gland androgen-regulated protein 3A via estrogen receptor 2 in radioresistant head and neck squamous cell carcinoma cells
Jennifer Grünow, Chao Rong, Jan Hischmann, Karim Zaoui, Christa Flechtenmacher, Klaus-Josef Weber, Peter Plinkert, Jochen Hess
Human breast adipose tissue: characterization of factors that change during tumor progression in human breast cancer
Sabrina Johanna Fletcher, Paula Alejandra Sacca, Mercedes Pistone-Creydt, Federico Andrés Coló, María Florencia Serra, Flavia Eliana Santino, Corina Verónica Sasso, Constanza Matilde Lopez-Fontana, Rubén Walter Carón, Juan Carlos Calvo, Virginia Pistone-Creydt
Cancer cells increase endothelial cell tube formation and survival by activating the PI3K/Akt signalling pathway
Hao-Wei Cheng, Yi-Fang Chen, Jau-Min Wong, Chia-Wei Weng, Hsuan-Yu Chen, Sung-Liang Yu, Huei-Wen Chen, Ang Yuan, Jeremy J.W. Chen
Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice
Amanda B. Parris, Qingxia Zhao, Erin W. Howard, Ming Zhao, Zhikun Ma, Xiaohe Yang
MicroRNA-381 inhibits the metastasis of gastric cancer by targeting TMEM16A expression
Qinghua Cao, Fang Liu, Kaiyuan Ji, Ni Liu, Yuan He, Wenhui Zhang, Liantang Wang
PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer
Yun-Peng Peng, Yi Zhu, Ling-Di Yin, Jing-Jing Zhang, Ji-Shu Wei, Xian Liu, Xin-Chun Liu, Wen-Tao Gao, Kui-Rong Jiang, Yi Miao
Erratum to: Pathologically decreased expression of miR-193a contributes to metastasis by targeting WT1-E-cadherin axis in non-small cell lung cancers
Junjie Chen, Shenmeng Gao, Chunjing Wang, Zhonggai Wang, Huxiang Zhang, Kate Huang, Bin Zhou, Haiying Li, Zhijie Yu, Jianbo Wu, Chengshui Chen
Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization
Tiziana Bruno, Mariacristina Valerio, Luca Casadei, Francesca De Nicola, Frauke Goeman, Matteo Pallocca, Valeria Catena, Simona Iezzi, Cristina Sorino, Agata Desantis, Cesare Manetti, Giovanni Blandino, Aristide Floridi, Maurizio Fanciulli
Erratum to: CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling
Dong-Fang Meng, Ping Xie, Li-Xia Peng, Rui Sun, Dong-Hua Luo, Qiu-Yan Chen, Xing Lv, Lin Wang, Ming-Yuan Chen, Hai-Qiang Mai, Ling Guo, Xiang Guo, Li-Sheng Zheng, Li Cao, Jun-Ping Yang, Meng-Yao Wang, Yan Mei, Yuan-Yuan Qiang, Zi-Meng Zhang, Jing-Ping Yun, Bi-Jun Huang, Chao-Nan Qian
Erratum to: The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer
Jie Tang, Yi Zhu, Kunling Xie, Xiaoyu Zhang, Xiaofei Zhi, Weizhi Wang, Zheng Li, Qun Zhang, Linjun Wang, Jiwei Wang, Zekuan Xu
Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6
Yonghao Qi, Ambara R. Pradipta, Miao Li, Xuan Zhao, Lulu Lu, Xuegang Fu, Jing Wei, Richard P. Hsung, Katsunori Tanaka, Lijun Zhou
Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer
Yoshitaro Shindo, Shoichi Hazama, Nobuaki Suzuki, Haruo Iguchi, Kazuhiro Uesugi, Hiroaki Tanaka, Atsushi Aruga, Takashi Hatori, Hidenobu Ishizaki, Yuzo Umeda, Toshiyoshi Fujiwara, Tetsuya Ikemoto, Mitsuo Shimada, Kazuhiko Yoshimatsu, Hiroko Takenouchi, Hiroto Matsui, Shinsuke Kanekiyo, Michihisa Iida, Yasunobu Koki, Hideki Arima, Hiroyuki Furukawa, Tomio Ueno, Shigefumi Yoshino, Tomonobu Fujita, Yutaka Kawakami, Yusuke Nakamura, Masaaki Oka, Hiroaki Nagano
Prognostic stratification improvement by integrating ID1/ID3/IGJ gene expression signature and immunophenotypic profile in adult patients with B-ALL
Nataly Cruz-Rodriguez, Alba L. Combita, Leonardo J. Enciso, Lauren F. Raney, Paula L. Pinzon, Olga C. Lozano, Alba M. Campos, Niyireth Peñaloza, Julio Solano, Maria V. Herrera, Jovanny Zabaleta, Sandra Quijano
Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells
Yeonhwa Song, Jaewoo Jang, Tae-Hoon Shin, Sang Mun Bae, Jin-sun Kim, Kang Mo Kim, Seung-Jae Myung, Eun Kyung Choi, Haeng Ran Seo
PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients
Ming Li, Shanhu Li, Biao Liu, Meng-Meng Gu, Shitao Zou, Bei-Bei Xiao, Lan Yu, Wei-Qun Ding, Ping-Kun Zhou, Jundong Zhou, Zeng-Fu Shang
E2F8, a direct target of miR-144, promotes papillary thyroid cancer progression via regulating cell cycle
Jing Sun, Run Shi, Sha Zhao, Xiaona Li, Shan Lu, Hemei Bu, Xianghua Ma, Chuan Su
Notch signaling plays a crucial role in cancer stem-like cells maintaining stemness and mediating chemotaxis in renal cell carcinoma
Wei Xiao, Zhiyong Gao, Yixing Duan, Wuxiong Yuan, Yang Ke
Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation
Yali Zhou, Yan Zhao, Yaoying Gao, Wenjun Hu, Yan Qu, Ning Lou, Ying Zhu, Xiaoping Zhang, Hongmei Yang
Inhibition of autophagy enhances the selective anti-cancer activity of tigecycline to overcome drug resistance in the treatment of chronic myeloid leukemia
Ziyuan Lu, Na Xu, Bolin He, Chengyun Pan, Yangqing Lan, Hongsheng Zhou, Xiaoli Liu
Chrysin inhibited tumor glycolysis and induced apoptosis in hepatocellular carcinoma by targeting hexokinase-2
Dong Xu, Junzhe Jin, Hao Yu, Zheming Zhao, Dongyan Ma, Chundong Zhang, Honglei Jiang
MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2
Lei Ding, Shanyong Zhang, Mu Xu, Renwen Zhang, Pengcheng Sui, Qing Yang
Sex-determining region Y-box protein 3 induces epithelial-mesenchymal transition in osteosarcoma cells via transcriptional activation of Snail1
Manle Qiu, Daoyun Chen, Chaoyong Shen, Ji Shen, Huakun Zhao, Yaohua He
Curcumin suppresses gastric tumor cell growth via ROS-mediated DNA polymerase γ depletion disrupting cellular bioenergetics
Lihua Wang, Xiwen Chen, Zhuanyun Du, Gefei Li, Mayun Chen, Xi Chen, Guang Liang, Tongke Chen
iASPP induces EMT and cisplatin resistance in human cervical cancer through miR-20a-FBXL5/BTG3 signaling
Ying Xiong, Fei Sun, Peixin Dong, Hidemichi Watari, Junming Yue, Min-fei Yu, Chun-yan Lan, Yin Wang, Ze-biao Ma
The role of c-Myc-RBM38 loop in the growth suppression in breast cancer
Xiao-Xia Li, Liang Shi, Xu-Jie Zhou, Jing Wu, Tian-Song Xia, Wen-Bin Zhou, Xi Sun, Lei Zhu, Ji-Fu Wei, Qiang Ding
Itraconazole induces apoptosis and cell cycle arrest via inhibiting Hedgehog signaling in gastric cancer cells
Qiang Hu, Yi-Chao Hou, Jiao Huang, Jing-Yuan Fang, Hua Xiong
The long non-coding RNA TP73-AS1 modulates HCC cell proliferation through miR-200a-dependent HMGB1/RAGE regulation
Shaling Li, Yan Huang, Yun Huang, Yongming Fu, Daolin Tang, Rui Kang, Rongrong Zhou, Xue-gong Fan
Distinct activity of the bone-targeted gallium compound KP46 against osteosarcoma cells - synergism with autophagy inhibition
Bernd Kubista, Thomas Schoefl, Lisa Mayr, Sushilla van Schoonhoven, Petra Heffeter, Reinhard Windhager, Bernhard K. Keppler, Walter Berger
Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma, Lisong Shen
Long non-coding RNA NKILA inhibits migration and invasion of non-small cell lung cancer via NF-κB/Snail pathway
Zhiliang Lu, Yuan Li, Jingnan Wang, Yun Che, Shouguo Sun, Jianbing Huang, Zhaoli Chen, Jie He
Genotypes of SLC22A4 and SLC22A5 regulatory loci are predictive of the response of chronic myeloid leukemia patients to imatinib treatment
Monika Jaruskova, Nikola Curik, Rajna Hercog, Vaclava Polivkova, Eliska Motlova, Vladimir Benes, Hana Klamova, Pavla Pecherkova, Petra Belohlavkova, Filip Vrbacky, Katerina Machova Polakova
Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels
Chenbo Ding, Junmin Luo, Xiaobo Fan, Longmei Li, Shanshan Li, Kunming Wen, Jihong Feng, Guoqiu Wu
Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
Sabine Heublein, Doris Mayr, Alfons Meindl, Alexandra Kircher, Udo Jeschke, Nina Ditsch
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Wei Li, Mengzhu Zheng, Shuangping Wu, Suyu Gao, Mei Yang, Zhimei Li, Qiuxia Min, Weiguang Sun, Lixia Chen, Guangya Xiang, Hua Li
Overexpression of miR-584-5p inhibits proliferation and induces apoptosis by targeting WW domain-containing E3 ubiquitin protein ligase 1 in gastric cancer
Qing Li, Zheng Li, Song Wei, Weizhi Wang, Zheng Chen, Lei Zhang, Liang Chen, Bowen Li, Guangli Sun, Jianghao Xu, Qiang Li, Lu Wang, Zhipeng Xu, Yiwen Xia, Diancai Zhang, Hao Xu, Zekuan Xu
HIF-1α promoted vasculogenic mimicry formation in hepatocellular carcinoma through LOXL2 up-regulation in hypoxic tumor microenvironment
Meili Wang, Xiulan Zhao, Dongwang Zhu, Tieju Liu, Xiaohui Liang, Fang Liu, Yanhui Zhang, Xueyi Dong, Baocun Sun
Retraction Note: MicroRNA-203 suppresses gastric cancer growth by targeting PIBF1/Akt signaling
Shao-Jun Chu, Ge Wang, Peng-Fei Zhang, Rui Zhang, Yan-Xia Huang, Yun-Min Lu, Wei Da, Qun Sun, Jing Zhang, Jin-Shui Zhu
Overexpression of RKIP and its cross-talk with several regulatory gene products in multiple myeloma
Anna Shvartsur, Kevin B. Givechian, Hermes Garban, Benjamin Bonavida
FOXM1 expression is significantly associated with chemotherapy resistance and adverse prognosis in non-serous epithelial ovarian cancer patients
Renata A. Tassi, Paola Todeschini, Eric R. Siegel, Stefano Calza, Paolo Cappella, Laura Ardighieri, Moris Cadei, Mattia Bugatti, Chiara Romani, Elisabetta Bandiera, Laura Zanotti, Laura Tassone, Donatella Guarino, Concetta Santonocito, Ettore D. Capoluongo, Luca Beltrame, Eugenio Erba, Sergio Marchini, Maurizio D’Incalci, Carla Donzelli, Alessandro D. Santin, Sergio Pecorelli, Enrico Sartori, Eliana Bignotti, Franco Odicino, Antonella Ravaggi
Heat shock factor 1 inhibits the mitochondrial apoptosis pathway by regulating second mitochondria-derived activator of caspase to promote pancreatic tumorigenesis
Wenjin Liang, Yong Liao, Jing Zhang, Qi Huang, Wei Luo, Jidong Yu, Jianhua Gong, Yi Zhou, Xuan Li, Bo Tang, Songqing He, Jinghong Yang
AHNAK suppresses tumour proliferation and invasion by targeting multiple pathways in triple-negative breast cancer
Bo Chen, Jin Wang, Danian Dai, Qingyu Zhou, Xiaofang Guo, Zhi Tian, Xiaojia Huang, Lu Yang, Hailin Tang, Xiaoming Xie
Lysophosphatidylcholine acyltransferase 1 upregulation and concomitant phospholipid alterations in clear cell renal cell carcinoma
Yiqing Du, Qiang Wang, Xingzhong Zhang, Xiaofeng Wang, Caipeng Qin, Zhengzuo Sheng, Huaqi Yin, Changtao Jiang, Jing Li, Tao Xu
Novel glycolipid agents for killing cisplatin-resistant human epithelial ovarian cancer cells
Amani I. Moraya, Jennifer L. Ali, Pranati Samadder, Lisa Liang, Ludivine Coudière Morrison, Tamra E. Werbowetski-Ogilvie, Makanjuola Ogunsina, Frank Schweizer, Gilbert Arthur, Mark W. Nachtigal
Dihydroartemisinin inhibits TCTP-dependent metastasis in gallbladder cancer
Fei Zhang, Qiang Ma, Zihang Xu, Haibin Liang, Huaifeng Li, Yuanyuan Ye, Shanshan Xiang, Yijian Zhang, Lin Jiang, Yunping Hu, Zheng Wang, Xuefeng Wang, Yong Zhang, Wei Gong, Yingbin Liu
Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase
Franco Di Filippo, Simona Di Filippo, Anna Maria Ferrari, Raffaele Antonetti, Alessandro Battaglia, Francesca Becherini, Laia Bernet, Renzo Boldorini, Catherine Bouteille, Simonetta Buglioni, Paolo Burelli, Rafael Cano, Vincenzo Canzonieri, Pierluigi Chiodera, Alfredo Cirilli, Luigi Coppola, Stefano Drago, Luca Di Tommaso, Privato Fenaroli, Roberto Franchini, Andrea Gianatti, Diana Giannarelli, Carmela Giardina, Florence Godey, Massimo M. Grassi, Giuseppe B. Grassi, Siobhan Laws, Samuele Massarut, Giuseppe Naccarato, Maria Iole Natalicchio, Sergio Orefice, Fabrizio Palmieri, Tiziana Perin, Manuela Roncella, Massimo G. Roncalli, Antonio Rulli, Angelo Sidoni, Corrado Tinterri, Maria C. Truglia, Isabella Sperduti
CIP2A mediates fibronectin-induced bladder cancer cell proliferation by stabilizing β-catenin
Fengbin Gao, Tianyuan Xu, Xianjin Wang, Shan Zhong, Shanwen Chen, Minguang Zhang, Xiaohua Zhang, Yifan Shen, Xiaojing Wang, Chen Xu, Zhoujun Shen
hrHPV E5 oncoprotein: immune evasion and related immunotherapies
Antonio Carlos de Freitas, Talita Helena Araújo de Oliveira, Marconi Rego Barros Jr., Aldo Venuti
FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells
Hong Yuan, Zi-Ming Li, Jiaxiang Shao, Wen-Xiang Ji, Weiliang Xia, Shun Lu
Intake of Boron, Cadmium, and Molybdenum enhances rat thyroid cell transformation
Emilia Luca, Laura Fici, Anna Ronchi, Ferdinando Marandino, Esther Diana Rossi, Maria Emiliana Caristo, Pasqualino Malandrino, Marco Russo, Alfredo Pontecorvi, Riccardo Vigneri, Fabiola Moretti
Rapamycin (mTORC1 inhibitor) reduces the production of lactate and 2-hydroxyglutarate oncometabolites in IDH1 mutant fibrosarcoma cells
Zoltán Hujber, Gábor Petővári, Norbert Szoboszlai, Titanilla Dankó, Noémi Nagy, Csilla Kriston, Ildikó Krencz, Sándor Paku, Olivér Ozohanics, László Drahos, András Jeney, Anna Sebestyén
ERβ1 inhibits metastasis of androgen receptor-positive triple-negative breast cancer by suppressing ZEB1
Wei Song, Lin Tang, Yumei Xu, Qian Sun, Fang Yang, Xiaoxiang Guan
In vitro antineoplastic effects of brivaracetam and lacosamide on human glioma cells
Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio, Emilio Ciusani
Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer
Nana Pei, Yingying Mao, Pengfei Wan, Xinglu Chen, Andrew Li, Huiying Chen, Jinlong Li, Renqiang Wan, Yanling Zhang, Hongyan Du, Baihong Chen, Guangyu Jiang, Minghan Xia, Colin Sumners, Guixue Hu, Dongsheng Gu, Hongwei Li
ANGPTL1 attenuates colorectal cancer metastasis by up-regulating microRNA-138
Haiyan Chen, Qian Xiao, Yeting Hu, Liubo Chen, Kai Jiang, Yang Tang, Yinuo Tan, Wangxiong Hu, Zhanhuai Wang, Jinjie He, Yue Liu, Yibo Cai, Qi Yang, Kefeng Ding
Platinum-containing compound platinum pyrithione suppresses ovarian tumor proliferation through proteasome inhibition
Hongbiao Huang, Ni Liu, Yuning Liao, Ningning Liu, Jianyu Cai, Xiaohong Xia, Zhiqiang Guo, Yanling Li, Qirong Wen, Qi Yin, Yan Liu, Qingxia Wu, Dhivya Rajakumar, Xiujie Sheng, Jinbao Liu
Type II CRISPR/Cas9 approach in the oncological therapy
A. Biagioni, A. Chillà, E. Andreucci, A. Laurenzana, F. Margheri, S. Peppicelli, M. Del Rosso, G. Fibbi
The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma
Xiaodong Feng, Qingqiong Luo, Han Zhang, Han Wang, Wantao Chen, Guangxun Meng, Fuxiang Chen
MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells
Zhong Zheng, Peng-Peng Xu, Li Wang, Hui-Jin Zhao, Xiang-Qin Weng, Hui-Juan Zhong, Bin Qu, Jie Xiong, Yan Zhao, Xue-Feng Wang, Anne Janin, Wei-Li Zhao
LPS alters the immuno-phenotype of glioma and glioma stem-like cells and induces in vivo antitumor immunity via TLR4
Sheng Han, Chao Wang, Xiaofei Qin, Junzhe Xia, Anhua Wu
High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation
Chunni Wang, Zitong Li, Fei Shao, Xueying Yang, Xiaoli Feng, Susheng Shi, Yibo Gao, Jie He
PHF21B overexpression promotes cancer stem cell-like traits in prostate cancer cells by activating the Wnt/β-catenin signaling pathway
Qiji Li, Liping Ye, Wei Guo, Min Wang, Shuai Huang, Xinsheng Peng
HOXB7 accelerates the malignant progression of hepatocellular carcinoma by promoting stemness and epithelial-mesenchymal transition
Hong-bo Huan, Da-peng Yang, Xu-dong Wen, Xue-jiao Chen, Liang Zhang, Li-li Wu, Ping Bie, Feng Xia
Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation
Lamia Aït Ghezali, Atousa Arbabian, Hervé Roudot, Jean-Philippe Brouland, Fanny Baran-Marszak, Evelyn Salvaris, Andrew Boyd, Hans G. Drexler, Agnes Enyedi, Remi Letestu, Nadine Varin-Blank, Bela Papp
RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma
Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Kazuhiko Takeuchi
Antibody targeting of claudin-1 as a potential colorectal cancer therapy
S. Cherradi, A. Ayrolles-Torro, N. Vezzo-Vié, N. Gueguinou, V. Denis, E. Combes, F. Boissière, M. Busson, L. Canterel-Thouennon, C. Mollevi, M. Pugnière, F. Bibeau, M. Ychou, P. Martineau, C. Gongora, M. Del Rio
CRISPR/Cas9 targeting of GPRC6A suppresses prostate cancer tumorigenesis in a human xenograft model
Ruisong Ye, Min Pi, John V. Cox, Satoru K. Nishimoto, L. Darryl Quarles
In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer
Megumi Fujita, Ai Hasegawa, Motohiro Yamamori, Noboru Okamura
Collagen triple helix repeat containing-1 negatively regulated by microRNA-30c promotes cell proliferation and metastasis and indicates poor prognosis in breast cancer
Yuan-hui Lai, Jian Chen, Xiao-ping Wang, Yan-qing Wu, Hai-tao Peng, Xiao-hong Lin, Wen-jian Wang
Alantolactone, a natural sesquiterpene lactone, has potent antitumor activity against glioblastoma by targeting IKKβ kinase activity and interrupting NF-κB/COX-2-mediated signaling cascades
Xun Wang, Zhenlong Yu, Chao Wang, Wei Cheng, Xiangge Tian, Xiaokui Huo, Yan Wang, Chengpeng Sun, Lei Feng, Jinshan Xing, Yulong Lan, Dongdong Sun, Qingjuan Hou, Baojing Zhang, Xiaochi Ma, Bo Zhang
Erratum to: RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma
Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Kazuhiko Takeuchi
Can recurrences be predicted in craniopharyngiomas? β-catenin coexisting with stem cells markers and p-ATM in a clinicopathologic study of 45cases
Elia Guadagno, Oreste de Divitiis, Domenico Solari, Giorgio Borrelli, Umberto Marcello Bracale, Alberto Di Somma, Paolo Cappabianca, Marialaura Del Basso De Caro
Ibrutinib, a Bruton’s tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma
Jin Wang, Xiaoyang Liu, Yongzhi Hong, Songtao Wang, Pin Chen, Aihua Gu, Xiaoyuan Guo, Peng Zhao
RETRACTED ARTICLE: Up-regulation of CDK16 by multiple mechanisms in hepatocellular carcinoma promotes tumor progression
Yitao Wang, Xian Qin, Tao Guo, Pengpeng Liu, Ping Wu, Zhisu Liu
Curcumin: the spicy modulator of breast carcinogenesis
Urmila Banik, Subramani Parasuraman, Arun Kumar Adhikary, Nor Hayati Othman
miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma
Chunlin Jiang, Jianting Long, Baoxian Liu, Ming Xu, Wei Wang, Xiaoyan Xie, Xiaolin Wang, Ming Kuang
Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2
Jin Sun, Xinhua Tian, Junqing Zhang, Yanlin Huang, Xiaoning Lin, Luyue Chen, Shizhong Zhang
Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells
Masahiro Yoshioka, Shinya Ohashi, Tomomi Ida, Yukie Nakai, Osamu Kikuchi, Yusuke Amanuma, Junichi Matsubara, Atsushi Yamada, Shin’ichi Miyamoto, Mitsuteru Natsuizaka, Hiroshi Nakagawa, Tsutomu Chiba, Hiroshi Seno, Manabu Muto
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
Stephen Riffle, Rashmi S. Hegde
Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
Yuyuan Yao, Kai Zhao, Zhou Yu, Haochuan Ren, Li Zhao, Zhiyu Li, Qinglong Guo, Na Lu
Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis
I. Aversa, F. Zolea, C. Ieranò, S. Bulotta, A. M. Trotta, M. C. Faniello, C. De Marco, D. Malanga, F. Biamonte, G. Viglietto, G. Cuda, S. Scala, F. Costanzo
Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma
Xue Zhang, Qiao-Li LV, Yuan-Tao Huang, Li-Hua Zhang, Hong-Hao Zhou
The anti-vascular endothelial growth factor receptor-1 monoclonal antibody D16F7 inhibits invasiveness of human glioblastoma and glioblastoma stem cells
Maria Grazia Atzori, Lucio Tentori, Federica Ruffini, Claudia Ceci, Lucia Lisi, Elena Bonanno, Manuel Scimeca, Eskil Eskilsson, Thomas Daubon, Hrvoje Miletic, Lucia Ricci Vitiani, Roberto Pallini, Pierluigi Navarra, Rolf Bjerkvig, Stefania D’Atri, Pedro Miguel Lacal, Grazia Graziani
Gambogic acid sensitizes gemcitabine efficacy in pancreatic cancer by reducing the expression of ribonucleotide reductase subunit-M2 (RRM2)
Guanggai Xia, Hongcheng Wang, Ziliang Song, Qingcai Meng, Xiuyan Huang, Xinyu Huang
Current concepts in bone metastasis, contemporary therapeutic strategies and ongoing clinical trials
Andrew S. Gdowski, Amalendu Ranjan, Jamboor K. Vishwanatha
Stathmin is overexpressed and regulated by mutant p53 in oral squamous cell carcinoma
Hai-long Ma, Shu-fang Jin, Wu-tong Ju, Yong Fu, Yao-yao Tu, Li-zhen Wang, Jiang-Li, Zhi-yuan Zhang, Lai-ping Zhong
Silencing the Girdin gene enhances radio-sensitivity of hepatocellular carcinoma via suppression of glycolytic metabolism
Li Yu, Yifan Sun, Jingjing Li, Yan Wang, Yuxing Zhu, Yong Shi, Xiaojun Fan, Jianda Zhou, Ying Bao, Jie Xiao, Ke Cao, Peiguo Cao
Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma
Yi Wang, Kai Chen, Yihong Cai, Yuanxia Cai, Xiaojun Yuan, Lifeng Wang, Zhixiang Wu, Yeming Wu
Combined targeting of Arf1 and Ras potentiates anticancer activity for prostate cancer therapeutics
Liwei Lang, Chloe Shay, Xiangdong Zhao, Yong Teng
Exosomes isolated from cancer patients’ sera transfer malignant traits and confer the same phenotype of primary tumors to oncosuppressor-mutated cells
Mohamed Abdouh, Dana Hamam, Zu-Hua Gao, Vincenzo Arena, Manuel Arena, Goffredo Orazio Arena
Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1)
Yixue Gu, Zhijie Zhang, Jiang Yin, Jiahui Ye, Yin Song, Hao Liu, Yan Xiong, Minying Lu, Guopei Zheng, Zhimin He
Combination therapy of PKCζ and COX-2 inhibitors synergistically suppress melanoma metastasis
Ping Zhou, Jiaqi Qin, Yuan Li, Guoxia Li, Yinsong Wang, Ning Zhang, Peng Chen, Chunyu Li
NLRP3 inflammasome activation promotes inflammation-induced carcinogenesis in head and neck squamous cell carcinoma
Cong-Fa Huang, Lei Chen, Yi-Cun Li, Lei Wu, Guang-Tao Yu, Wen-Feng Zhang, Zhi-Jun Sun
Maintenance of stemness is associated with the interation of LRP6 and heparin-binding protein CCN2 autocrined by hepatocellular carcinoma
Qingan Jia, Yang Bu, Zhiming Wang, Bendong Chen, Qiangbo Zhang, Songning Yu, Qingguang Liu
Trifluoperazine, a novel autophagy inhibitor, increases radiosensitivity in glioblastoma by impairing homologous recombination
Xin Zhang, Ran Xu, Chao Zhang, Yangyang Xu, Mingzhi Han, Bin Huang, Anjing Chen, Chen Qiu, Frits Thorsen, Lars Prestegarden, Rolf Bjerkvig, Jian Wang, Xingang Li
Ternary cocktail nanoparticles for sequential chemo-photodynamic therapy
Li Fan, Saisai Zhao, Qian Yang, Jiali Tan, Chaojun Song, Hong Wu
(S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1
Xuanxuan Dai, Guilong Guo, Peng Zou, Ri Cui, Weiqian Chen, Xi Chen, Changtian Yin, Wei He, Rajamanickam Vinothkumar, Fan Yang, Xiaohua Zhang, Guang Liang
High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods
Dan Su, Dadong Zhang, Kaiyan Chen, Jing Lu, Junzhou Wu, Xinkai Cao, Lisha Ying, Qihuang Jin, Yizhou Ye, Zhenghua Xie, Lei Xiong, Weimin Mao, Fugen Li
Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer
Bernhard Englinger, Sebastian Kallus, Julia Senkiv, Daniela Heilos, Lisa Gabler, Sushilla van Schoonhoven, Alessio Terenzi, Patrick Moser, Christine Pirker, Gerald Timelthaler, Walter Jäger, Christian R. Kowol, Petra Heffeter, Michael Grusch, Walter Berger
Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells
Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu, Zhimin He
Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
Zihang Xu, Fei Zhang, Chao Bai, Chao Yao, Hairong Zhong, Chunpu Zou, Xiao Chen
ICG-001 suppresses growth of gastric cancer cells and reduces chemoresistance of cancer stem cell-like population
Yi Liu, Hui Chen, Peiming Zheng, Yingxia Zheng, Qin Luo, Guohua Xie, Yanhui Ma, Lisong Shen
p53-Dependent PUMA to DRAM antagonistic interplay as a key molecular switch in cell-fate decision in normal/high glucose conditions
Alessia Garufi, Giuseppa Pistritto, Silvia Baldari, Gabriele Toietta, Mara Cirone, Gabriella D’Orazi
Nucleolar and spindle associated protein 1 promotes the aggressiveness of astrocytoma by activating the Hedgehog signaling pathway
Xianqiu Wu, Benke Xu, Chao Yang, Wentao Wang, Dequan Zhong, Zhan Zhao, Longshuang He, Yuanjun Hu, Lili Jiang, Jun Li, Libing Song, Wei Zhang
Liquid dynamic medicine and N-of-1 clinical trials: a change of perspective in oncology research
Nicola Silvestris, Gennaro Ciliberto, Paolo De Paoli, Giovanni Apolone, Maria Luisa Lavitrano, Marco A. Pierotti, Giorgio Stanta
PDL1 And LDHA act as ceRNAs in triple negative breast cancer by regulating miR-34a
Xiaojia Huang, Xinhua Xie, Hua Wang, Xiangsheng Xiao, Lu Yang, Zhi Tian, Xiaofang Guo, Lijuan Zhang, Hailin Tang, Xiaoming Xie
The acid-sensing ion channel, ASIC2, promotes invasion and metastasis of colorectal cancer under acidosis by activating the calcineurin/NFAT1 axis
Zhi-hang Zhou, Jin-wen Song, Wen Li, Xue Liu, Liu Cao, Lu-ming Wan, Ying-xia Tan, Shou-ping Ji, Yu-mei Liang, Feng Gong
miR-19b-3p promotes colon cancer proliferation and oxaliplatin-based chemoresistance by targeting SMAD4: validation by bioinformatics and experimental analyses
Tao Jiang, Ling Ye, Zhongbo Han, Yuan Liu, Yinxue Yang, Zhihai Peng, Junwei Fan
High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma
Chenglong Yue, Mingshan Niu, Qian Qian Shan, Ting Zhou, Yiming Tu, Peng Xie, Lei Hua, Rutong Yu, Xuejiao Liu
Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway
Xianxian Sui, Canjing Zhang, Jianan Zhou, Shengxuan Cao, Chen Xu, Feng Tang, Xiuling Zhi, Bobin Chen, Songmei Wang, Lianhua Yin
Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling
Jie Lin, Wansong Lin, Yunbin Ye, Liping Wang, Xiaoyan Chen, Shengbing Zang, Aimin Huang
Human mesenchymal stromal cells as cellular drug-delivery vectors for glioblastoma therapy: a good deal?
Anne Clavreul, Milad Pourbaghi-Masouleh, Emilie Roger, Nolwenn Lautram, Claudia N. Montero-Menei, Philippe Menei
β-catenin-mediated YAP signaling promotes human glioma growth
Yan Wang, Peng Pan, Zhaohao Wang, Yu Zhang, Peng Xie, Decheng Geng, Yang Jiang, Rutong Yu, Xiuping Zhou
The oncogenic Golgi phosphoprotein 3 like overexpression is associated with cisplatin resistance in ovarian carcinoma and activating the NF-κB signaling pathway
Shanyang He, Gang Niu, Jianhong Shang, Yalan Deng, Zhiyong Wan, Cai Zhang, Zeshan You, Hongwei Shen
MiR-203a-3p suppresses cell proliferation and metastasis through inhibiting LASP1 in nasopharyngeal carcinoma
Ning Jiang, Xuesong Jiang, Zhenzhang Chen, Xue Song, Lirong Wu, Dan Zong, Dan Song, Li Yin, Dejun Wang, Cheng Chen, Xiuhua Bian, Xia He
Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway
Pei-Jie Zhou, Wei Xue, Jinliang Peng, Yanqing Wang, Lianzi Wei, Ziqiang Yang, Helen He Zhu, Yu-Xiang Fang, Wei-Qiang Gao
IL-27 mediates HLA class I up-regulation, which can be inhibited by the IL-6 pathway, in HLA-deficient Small Cell Lung Cancer cells
Grazia Carbotti, Amin Reza Nikpoor, Paola Vacca, Rosaria Gangemi, Chiara Giordano, Francesco Campelli, Silvano Ferrini, Marina Fabbi
SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis
Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao, Xiuwen Wang
The α-melanocyte stimulating hormone/peroxisome proliferator activated receptor-γ pathway down-regulates proliferation in melanoma cell lines
Enrica Flori, Eleonora Rosati, Giorgia Cardinali, Daniela Kovacs, Barbara Bellei, Mauro Picardo, Vittoria Maresca
Breast carcinomas with low amplified/equivocal HER2 by Ish: potential supporting role of multiplex ligation-dependent probe amplification
Cristiana Ercolani, Caterina Marchiò, Anna Di Benedetto, Alessandra Fabi, Letizia Perracchio, Patrizia Vici, Francesca Sperati, Simonetta Buglioni, Vincenzo Arena, Edoardo Pescarmona, Anna Sapino, Irene Terrenato, Marcella Mottolese
YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer
Wei Li, Yuanyuan Cao, Jinling Xu, Ying Wang, Weijie Li, Qian Wang, Ziwei Hu, Yaping Hao, Li Hu, Yawen Sun, Guanglin Xu, Guizhen Ao
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a
Rongfang He, Peng Liu, Xiaoming Xie, Yujuan Zhou, Qianjin Liao, Wei Xiong, Xiaoling Li, Guiyuan Li, Zhaoyang Zeng, Hailin Tang
PAK5-mediated phosphorylation and nuclear translocation of NF-κB-p65 promotes breast cancer cell proliferation in vitro and in vivo
Ying-Chun Zhang, Fu-Chun Huo, Lu-Lu Wei, Chan-Chan Gong, Yao-Jie Pan, Jie Mou, Dong-Sheng Pei
Epigenetic mediated zinc finger protein 671 downregulation promotes cell proliferation and tumorigenicity in nasopharyngeal carcinoma by inhibiting cell cycle arrest
Jian Zhang, Xin Wen, Na Liu, Ying-Qin Li, Xin-Ran Tang, Ya-Qin Wang, Qing-Mei He, Xiao-Jing Yang, Pan-Pan Zhang, Jun Ma, Ying Sun
Upregulation of DARS2 by HBV promotes hepatocarcinogenesis through the miR-30e-5p/MAPK/NFAT5 pathway
Xian Qin, Changsheng Li, Tao Guo, Jing Chen, Hai-Tao Wang, Yi-Tao Wang, Yu-Sha Xiao, Jun Li, Pengpeng Liu, Zhi-Su Liu, Quan-Yan Liu
PTEN expression is upregulated by a RNA-binding protein RBM38 via enhancing its mRNA stability in breast cancer
Xu-Jie Zhou, Jing Wu, Liang Shi, Xiao-Xia Li, Lei Zhu, Xi Sun, Jia-Yi Qian, Ying Wang, Ji-Fu Wei, Qiang Ding
Musashi-2, a novel oncoprotein promoting cervical cancer cell growth and invasion, is negatively regulated by p53-induced miR-143 and miR-107 activation
Peixin Dong, Ying Xiong, Sharon J. B. Hanley, Junming Yue, Hidemichi Watari
Synthetic regulatory RNAs selectively suppress the progression of bladder cancer
Chengle Zhuang, Xinbo Huang, Changshui Zhuang, Xiaomin Luo, Xiaowei Zhang, Zhiming Cai, Yaoting Gui
Circular RNAs: emerging cancer biomarkers and targets
Yu Zhang, Wei Liang, Peng Zhang, Jingyan Chen, Hui Qian, Xu Zhang, Wenrong Xu
Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling
Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu, Jian Chen
Cooperative antitumor activities of carnosic acid and Trastuzumab in ERBB2+ breast cancer cells
Carolina D’Alesio, Grazia Bellese, Maria Cristina Gagliani, Cinzia Aiello, Elena Grasselli, Gianluca Marcocci, Angela Bisio, Sara Tavella, Tiziana Daniele, Katia Cortese, Patrizio Castagnola
TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas
Ming-Zhi Han, Ran Xu, Yang-Yang Xu, Xin Zhang, Shi-Lei Ni, Bin Huang, An-Jing Chen, Yu-Zhen Wei, Shuai Wang, Wen-Jie Li, Qing Zhang, Gang Li, Xin-Gang Li, Jian Wang
STAT3-blocked whole-cell hepatoma vaccine induces cellular and humoral immune response against HCC
Qiuju Han, Yaqun Wang, Min Pang, Jian Zhang
CLDN6 promotes chemoresistance through GSTP1 in human breast cancer
Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, Chengshi Quan
MiR-361-5p inhibits glycolytic metabolism, proliferation and invasion of breast cancer by targeting FGFR1 and MMP-1
Fei Ma, Lei Zhang, Li Ma, Yiyun Zhang, Jianguo Zhang, Baoliang Guo
Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer
Zhixin Ling, Xiaoyan Wang, Tao Tao, Lei Zhang, Han Guan, Zonghao You, Kai Lu, Guangyuan Zhang, Shuqiu Chen, Jianping Wu, Jinke Qian, Hui Liu, Bin Xu, Ming Chen
Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer
Jia-Qi Wu, Jing Zhai, Chong-Yong Li, Ai-Min Tan, Ping Wei, Li-Zong Shen, Ming-Fang He
Downregulation of MiR-31 stimulates expression of LATS2 via the hippo pathway and promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma
Yanping Gao, Jun Yi, Kai Zhang, Fan Bai, Bing Feng, Rui Wang, Xiaoyuan Chu, Longbang Chen, Haizhu Song
RETRACTED ARTICLE: TGF-β2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells’ invasion
Chao Zhang, Xin Zhang, Ran Xu, Bin Huang, An-Jing Chen, Chao Li, Jian Wang, Xin-Gang Li
Doxorubicin combined with low intensity ultrasound suppresses the growth of oral squamous cell carcinoma in culture and in xenografts
Haixia Fan, Haixia Li, Guanyao Liu, Wei Cong, Hong Zhao, Wenwu Cao, Jinhua Zheng
Cisplatin triggers cancer stem cell enrichment in platinum-resistant cells through NF-κB-TNFα-PIK3CA loop
Bhushan Thakur, Pritha Ray
Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma
H. Huebner, R. Strick, D. L. Wachter, S. Kehl, P. L. Strissel, R. Schneider-Stock, A. Hartner, W. Rascher, L. C. Horn, M. W. Beckmann, M. Ruebner, F. B. Fahlbusch
ID1 promotes hepatocellular carcinoma proliferation and confers chemoresistance to oxaliplatin by activating pentose phosphate pathway
Xin Yin, Bei Tang, Jing-Huan Li, Yan Wang, Lan Zhang, Xiao-Ying Xie, Bo-Heng Zhang, Shuang-Jian Qiu, Wei-Zhong Wu, Zheng-Gang Ren
Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
Marisa Granato, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Site-specific selection reveals selective constraints and functionality of tumor somatic mtDNA mutations
Deyang Li, Xiaohong Du, Xu Guo, Lei Zhan, Xin Li, Chun Yin, Cheng Chen, Mingkun Li, Bingshan Li, Hushan Yang, Jinliang Xing
Drug repurposing for the treatment of glioblastoma multiforme
Claudia Abbruzzese, Silvia Matteoni, Michele Signore, Luca Cardone, Kavindra Nath, Jerry D. Glickson, Marco G. Paggi
ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/β-catenin pathway
Juntang Yang, Fei Han, Wenbin Liu, Hongqiang Chen, Xianglin Hao, Xiao Jiang, Li Yin, Yongsheng Huang, Jia Cao, Huidong Zhang, Jinyi Liu
Autophagy maintains the stemness of ovarian cancer stem cells by FOXA2.
Qiaohua Peng, Jiale Qin, Yanan Zhang, Xiaodong Cheng, Xinyu Wang, Weiguo Lu, Xing Xie, Songfa Zhang
Direct inhibition of ACTN4 by ellagic acid limits breast cancer metastasis via regulation of β-catenin stabilization in cancer stem cells
Neng Wang, Qi Wang, Hailin Tang, Fengxue Zhang, Yifeng Zheng, Shengqi Wang, Jin Zhang, Zhiyu Wang, Xiaoming Xie
Downregulation of miR-141-3p promotes bone metastasis via activating NF-κB signaling in prostate cancer
Shuai Huang, Qingde Wa, Jincheng Pan, Xinsheng Peng, Dong Ren, Yan Huang, Xiao Chen, Yubo Tang
Trastuzumab emtansine delays and overcomes resistance to the third-generation EGFR-TKI osimertinib in NSCLC EGFR mutated cell lines
Silvia La Monica, Daniele Cretella, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Graziana Digiacomo, Lisa Flammini, Elisabetta Barocelli, Roberta Minari, Nadia Naldi, Pier Giorgio Petronini, Marcello Tiseo, Roberta Alfieri
FOXA1 inhibits hepatocellular carcinoma progression by suppressing PIK3R1 expression in male patients
Shujiao He, Junyi Zhang, Wan Zhang, Fengsheng Chen, Rongcheng Luo
Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas
Qifeng Wang, Hualei Gan, Chengshu Chen, Yifeng Sun, Jinying Chen, Midie Xu, Weiwei Weng, Liyu Cao, Qinghua Xu, Jian Wang
Synergistic antitumor interaction between valproic acid, capecitabine and radiotherapy in colorectal cancer: critical role of p53
Manuela Terranova-Barberio, Biagio Pecori, Maria Serena Roca, Serena Imbimbo, Francesca Bruzzese, Alessandra Leone, Paolo Muto, Paolo Delrio, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro
Silencing of miR-193a-5p increases the chemosensitivity of prostate cancer cells to docetaxel
Zhan Yang, Jin-Suo Chen, Jin-Kun Wen, Hai-Tao Gao, Bin Zheng, Chang-Bao Qu, Kai-Long Liu, Man-Li Zhang, Jun-Fei Gu, Jing-Dong Li, Yan-Ping Zhang, Wei Li, Xiao-Lu Wang, Yong Zhang
PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer
Song Gao, Anqi Ge, Shouping Xu, Zilong You, Shipeng Ning, Yashuang Zhao, Da Pang
Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells
Concetta Ragone, Michele Minopoli, Vincenzo Ingangi, Giovanni Botti, Federica Fratangelo, Antonello Pessi, Maria Patrizia Stoppelli, Paolo Antonio Ascierto, Gennaro Ciliberto, Maria Letizia Motti, Maria Vincenza Carriero
Lipoxin A4 reverses mesenchymal phenotypes to attenuate invasion and metastasis via the inhibition of autocrine TGF-β1 signaling in pancreatic cancer
Liang Zong, Ke Chen, Zhengdong Jiang, Xin Chen, Liankang Sun, Jiguang Ma, Cancan Zhou, Qinhong Xu, Wanxing Duan, Liang Han, Jianjun Lei, Xuqi Li, Qingyong Ma, Zheng Wang
Linc-ROR promotes esophageal squamous cell carcinoma progression through the derepression of SOX9
Lianghai Wang, Xiaodan Yu, Zhiyu Zhang, Lijuan Pang, Jiang Xu, Jinfang Jiang, Weihua Liang, Yuhang Chai, Jun Hou, Feng Li
Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4
Jihua Nie, Jingying Zhang, Lili Wang, Lunjie Lu, Qian Yuan, Fangmei An, Shuyu Zhang, Yang Jiao
Correction to: Calycosin inhibits the in vitro and in vivo growth of breast cancer cells through WDR7-7-GPR30 Signaling
Jing Tian, Yong Wang, Xing Zhang, Qianyao Ren, Rong Li, Yue Huang, Huiling Lu, Jian Chen
Smoldering mantle cell lymphoma
Haige Ye, Aakash Desai, Dongfeng Zeng, Krystle Nomie, Jorge Romaguera, Makhdum Ahmed, Michael L. Wang
Inhibition of EGR1 inhibits glioma proliferation by targeting CCND1 promoter
Dian-gang Chen, Bo Zhu, Sheng-qing Lv, Hongfan Zhu, Jinliang Tang, Changlin Huang, Qingrui Li, Pu Zhou, Dong-lin Wang, Guang-hui Li
5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin
Kaja Lund, Cathrine Elisabeth Olsen, Judith Jing Wen Wong, Petter Angell Olsen, Nina Therese Solberg, Anders Høgset, Stefan Krauss, Pål Kristian Selbo
Interaction of the epigenetic integrator UHRF1 with the MYST domain of TIP60 inside the cell
Waseem Ashraf, Christian Bronner, Liliyana Zaayter, Tanveer Ahmad, Ludovic Richert, Mahmoud Alhosin, Abdulkhaleg Ibrahim, Ali Hamiche, Yves Mely, Marc Mousli
Diagnosis and treatment of ALT tumors: is Trabectedin a new therapeutic option?
Luca Pompili, Carlo Leonetti, Annamaria Biroccio, Erica Salvati
RETRACTED ARTICLE: Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice
Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao, Jun Zhang
Short course hypofractionated whole breast irradiation after conservative surgery: a single institution phase II study
Paola Pinnarò, Carolina Giordano, Alessia Farneti, Adriana Faiella, Giuseppe Iaccarino, Valeria Landoni, Diana Giannarelli, Patrizia Vici, Lidia Strigari, Giuseppe Sanguineti
The changing face of clinical trials in the personalized medicine and immuno-oncology era: report from the international congress on clinical trials in Oncology & Hemato-Oncology (ICTO 2017)
Talia Golan, Michele Milella, Aliza Ackerstein, Ranaan Berger
PDGFA/PDGFRα-regulated GOLM1 promotes human glioma progression through activation of AKT
Ran Xu, Jianxiong Ji, Xin Zhang, Mingzhi Han, Chao Zhang, Yangyang Xu, Yuzhen Wei, Shuai Wang, Bin Huang, Anjing Chen, Di Zhang, Qing Zhang, Wenjie Li, Zheng Jiang, Jian Wang, Xingang Li
LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway
Yanxia Huang, Jing Zhang, Lidan Hou, Ge Wang, Hui Liu, Rui Zhang, Xiaoyu Chen, Jinshui Zhu