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Zeitschrift

Journal of Hematology & Oncology

Journal of Hematology & Oncology 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 175 Artikel )

01.12.2017 | Review | Ausgabe 1/2017 Open Access

A new insight in chimeric antigen receptor-engineered T cells for cancer immunotherapy

Erhao Zhang, Hanmei Xu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Circular RNAs in cancer: an emerging key player

Yeping Dong, Dan He, Zhenzi Peng, Wei Peng, Wenwen Shi, Jun Wang, Bin Li, Chunfang Zhang, Chaojun Duan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients

Adil Daud, Japinder Gill, Sheily Kamra, Lei Chen, Amit Ahuja

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Cocktail treatment with EGFR-specific and CD133-specific chimeric antigen receptor-modified T cells in a patient with advanced cholangiocarcinoma

Kai-chao Feng, Ye-lei Guo, Yang Liu, Han-ren Dai, Yao Wang, Hai-yan Lv, Jian-hua Huang, Qing-ming Yang, Wei-dong Han

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma

Giovanni Luca Gravina, Andrea Mancini, Francesco Marampon, Alessandro Colapietro, Simona Delle Monache, Roberta Sferra, Flora Vitale, Peter J. Richardson, Lee Patient, Stephen Burbidge, Claudio Festuccia

01.12.2017 | Research | Ausgabe 1/2017 Open Access

XIAP BIR domain suppresses miR-200a expression and subsequently promotes EGFR protein translation and anchorage-independent growth of bladder cancer cell

Chao Huang, Xingruo Zeng, Guosong Jiang, Xin Liao, Claire Liu, Jingxia Li, Honglei Jin, Junlan Zhu, Hong Sun, Xue-Ru Wu, Chuanshu Huang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Different clinical characteristics and treatment strategies for patients with localized sinonasal diffuse large B cell lymphoma and extranodal NK/T cell lymphoma

Yu Huang, Bo Jia, Shiyu Jiang, Shengyu Zhou, Jianliang Yang, Peng Liu, Lin Gui, Xiaohui He, Yan Qin, Yan Sun, Yuankai Shi

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Nuclear microRNAs in normal hemopoiesis and cancer

John E.J. Rasko, Justin J.-L. Wong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer

Daniela Massihnia, Amir Avan, Niccola Funel, Mina Maftouh, Anne van Krieken, Carlotta Granchi, Rajiv Raktoe, Ugo Boggi, Babette Aicher, Filippo Minutolo, Antonio Russo, Leticia G. Leon, Godefridus J. Peters, Elisa Giovannetti

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy

Pablo Angulo, Gaurav Kaushik, Dharmalingam Subramaniam, Prasad Dandawate, Kathleen Neville, Katherine Chastain, Shrikant Anant

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis

Yu-Chan Chang, Li-Hsing Chi, Wei-Ming Chang, Chia-Yi Su, Yuang-Feng Lin, Chi-Long Chen, Ming-Huang Chen, Peter Mu-Hsin Chang, Alex T. H. Wu, Michael Hsiao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Is CD47 an innate immune checkpoint for tumor evasion?

Xiaojuan Liu, Hyunwoo Kwon, Zihai Li, Yang-xin Fu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Indatuximab ravtansine (BT062) combination treatment in multiple myeloma: pre-clinical studies

Kurt Schönfeld, Chantal Zuber, Jan Pinkas, Thomas Häder, Katrin Bernöster, Christoph Uherek

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue

Gang Liu, Jinyu Zhang, Lewis Frey, Xiao Gang, Kongming Wu, Qian Liu, Michael Lilly, Jennifer Wu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Can pegylated interferon improve the outcome of polycythemia vera patients?

Elena Crisà, Marco Cerrano, Eloise Beggiato, Giulia Benevolo, Giuseppe Lanzarone, Paola Maria Manzini, Alessandra Borchiellini, Ludovica Riera, Mario Boccadoro, Dario Ferrero

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis

Moitza Principe, Simone Borgoni, Mariafrancesca Cascione, Michelle Samuel Chattaragada, Sammy Ferri-Borgogno, Michela Capello, Sara Bulfamante, Jennifer Chapelle, Francesca Di Modugno, Paola Defilippi, Paola Nisticò, Paola Cappello, Chiara Riganti, Stefano Leporatti, Francesco Novelli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase

Zhimin Gu, Jiliang Xia, Hongwei Xu, Ivana Frech, Guido Tricot, Fenghuang Zhan

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

5’UTR point substitutions and N-terminal truncating mutations of ANKRD26 in acute myeloid leukemia

Caterina Marconi, Ilaria Canobbio, Valeria Bozzi, Tommaso Pippucci, Giorgia Simonetti, Federica Melazzini, Silvia Angori, Giovanni Martinelli, Giuseppe Saglio, Mauro Torti, Ira Pastan, Marco Seri, Alessandro Pecci

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism

Rihan El Bezawy, Michelandrea De Cesare, Marzia Pennati, Marcello Deraco, Paolo Gandellini, Valentina Zuco, Nadia Zaffaroni

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Allogeneic stem cell transplantation in adult patients with acute myeloid leukaemia and 17p abnormalities in first complete remission: a study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Xavier Poiré, Myriam Labopin, Johan Maertens, Ibrahim Yakoub-Agha, Didier Blaise, Norbert Ifrah, Gérard Socié, Tobias Gedde-Dhal, Nicolaas Schaap, Jan J. Cornelissen, Stéphane Vigouroux, Jaime Sanz, Lucienne Michaux, Jordi Esteve, Mohamad Mohty, Arnon Nagler

01.12.2017 | Rapid communication | Ausgabe 1/2017 Open Access

Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients

Dominique Farge, Lucas C. M. Arruda, Fanny Brigant, Emmanuel Clave, Corinne Douay, Zora Marjanovic, Christophe Deligny, Guitta Maki, Eliane Gluckman, Antoine Toubert, Helene Moins-Teisserenc

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Safety and efficacy of fruquintinib in patients with previously treated metastatic colorectal cancer: a phase Ib study and a randomized double-blind phase II study

Rui-Hua Xu, Jin Li, Yuxian Bai, Jianming Xu, Tianshu Liu, Lin Shen, Liwei Wang, Hongming Pan, Junning Cao, Dongsheng Zhang, Songhua Fan, Ye Hua, Weiguo Su

01.12.2017 | Research | Ausgabe 1/2017 Open Access

EPCR promotes breast cancer progression by altering SPOCK1/testican 1-mediated 3D growth

Naiara Perurena, Carolina Zandueta, Susana Martínez-Canarias, Haritz Moreno, Silvestre Vicent, Ana S. Almeida, Elisabet Guruceaga, Roger R. Gomis, Marta Santisteban, Mikala Egeblad, José Hermida, Fernando Lecanda

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A comparison between allogeneic stem cell transplantation from unmanipulated haploidentical and unrelated donors in acute leukemia

Simona Piemontese, F. Ciceri, M. Labopin, W. Arcese, S. Kyrcz-Krzemien, S. Santarone, H. Huang, D. Beelen, N. C. Gorin, C. Craddock, Z. Gulbas, A. Bacigalupo, M. Mohty, A. Nagler, on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant

Lan-Ping Xu, Song Jin, Shun-Qing Wang, Ling-Hui Xia, Hai Bai, Su-Jun Gao, Qi-Fa Liu, Jian-Min Wang, Xin Wang, Ming Jiang, Xi Zhang, De-Pei Wu, Xiao-Jun Huang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene

Riccardo Masetti, Salvatore Nicola Bertuccio, Annalisa Astolfi, Francesca Chiarini, Annalisa Lonetti, Valentina Indio, Matilde De Luca, Jessica Bandini, Salvatore Serravalle, Monica Franzoni, Martina Pigazzi, Alberto Maria Martelli, Giuseppe Basso, Franco Locatelli, Andrea Pession

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Studying hematopoiesis using single-cell technologies

Fang Ye, Wentao Huang, Guoji Guo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis

Heya Na, Xiaoli Liu, Xiaomeng Li, Xinsheng Zhang, Yu Wang, Zhaohui Wang, Menglang Yuan, Yu Zhang, Shuangyi Ren, Yunfei Zuo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer

Xiaoxue Zhang, Dan Liu, Mengchen Li, Canhui Cao, Dongyi Wan, Bixin Xi, Wenqian Li, Jiahong Tan, Ji Wang, Zhongcai Wu, Ding Ma, Qinglei Gao

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

High WT1 expression is an early predictor for relapse in patients with acute promyelocytic leukemia in first remission with negative PML-RARa after anthracycline-based chemotherapy: a single-center cohort study

Jae-Ho Yoon, Hee-Je Kim, Dae-Hun Kwak, Sung-Soo Park, Young-Woo Jeon, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong Wook Lee, Woo-Sung Min

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Impact of in vivo T cell depletion in HLA-identical allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission conditioned with a fludarabine iv-busulfan myeloablative regimen: a report from the EBMT Acute Leukemia Working Party

Marie Thérèse Rubio, Maud D’Aveni-Piney, Myriam Labopin, Rose-Marie Hamladji, Miguel A. Sanz, Didier Blaise, Hakan Ozdogu, Etienne Daguindeau, Carlos Richard, Stella Santarone, Giuseppe Irrera, Ibrahim Yakoub-Agha, Moshe Yeshurun, Jose L. Diez-Martin, Mohamad Mohty, Bipin N Savani, Arnon Nagler

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

MiR-194 functions as a tumor suppressor in laryngeal squamous cell carcinoma by targeting Wee1

Pei Li, Yang Yang, Hui Liu, An-Kui Yang, Jin-Ming Di, Guang-Mou Tan, Hai-Feng Wang, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei, Jia-Rong Huang, Kun Wang, Zhi Shi, Jin Ye

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression

Po-Chun Chen, Chih-Hsin Tang, Liang-Wei Lin, Chun-Hao Tsai, Cheng-Ying Chu, Tien-Huang Lin, Yuan-Li Huang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

PD-1, PD-L1 (B7-H1) and Tumor-Site Immune Modulation Therapy: The Historical Perspective

Jun Wang, Ruirong Yuan, Wenru Song, Jingwei Sun, Delong Liu, Zihai Li

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Allogeneic CD19-CAR-T cell infusion after allogeneic hematopoietic stem cell transplantation in B cell malignancies

Jun Liu, Jiang F. Zhong, Xi Zhang, Cheng Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

Yulei Chen, Siyuan Zhang, Qizhi Wang, Xiaobo Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Klotho, an anti-aging gene, acts as a tumor suppressor and inhibitor of IGF-1R signaling in diffuse large B cell lymphoma

Xiangxiang Zhou, Xiaosheng Fang, Yujie Jiang, Lingyun Geng, Xinyu Li, Ying Li, Kang Lu, Peipei Li, Xiao Lv, Xin Wang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

New treatment options for metastatic renal cell carcinoma with prior anti-angiogenesis therapy

Kevin Zarrabi, Chunhui Fang, Shenhong Wu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

Chau-To Kwok, Amy D. Marshall, John E. J. Rasko, Justin J. L. Wong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways

Ya-feng Li, Gayani Nanayakkara, Yu Sun, Xinyuan Li, Luqiao Wang, Ramon Cueto, Ying Shao, Hangfei Fu, Candice Johnson, Jiali Cheng, Xiongwen Chen, Wenhui Hu, Jun Yu, Eric T. Choi, Hong Wang, Xiao-feng Yang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Clinical implications of genome-wide DNA methylation studies in acute myeloid leukemia

Yan Li, Qingyu Xu, Na Lv, Lili Wang, Hongmei Zhao, Xiuli Wang, Jing Guo, Chongjian Chen, Yonghui Li, Li Yu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

A novel monoclonal antibody against the von Willebrand Factor A2 domain reduces its cleavage by ADAMTS13

Lulu Zhang, Jian Su, Fei Shen, Zhenni Ma, Yiming Zhao, Lijun Xia, Changgeng Ruan

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

João Ramalho-Carvalho, Inês Graça, Antonio Gomez, Jorge Oliveira, Rui Henrique, Manel Esteller, Carmen Jerónimo

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The dynamics of RUNX1-RUNX1T1 transcript levels after allogeneic hematopoietic stem cell transplantation predict relapse in patients with t(8;21) acute myeloid leukemia

Ya-Zhen Qin, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yao Chen, Xiao-Dong Mo, Xiao-Su Zhao, Ying-Jun Chang, Kai-Yan Liu, Xiao-Jun Huang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Clinical impact of extensive molecular profiling in advanced cancer patients

Sophie Cousin, Thomas Grellety, Maud Toulmonde, Céline Auzanneau, Emmanuel Khalifa, Yec’han Laizet, Kevin Tran, Sylvestre Le Moulec, Anne Floquet, Delphine Garbay, Jacques Robert, Isabelle Hostein, Isabelle Soubeyran, Antoine Italiano

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia

Lili Tao, Qingshu Zeng, June Li, Miao Xu, Jiajia Wang, Ying Pan, Huiping Wang, Qianshan Tao, Yang Chen, Jun Peng, Ming Hou, Arend Jan Gerard Jansen, Heyu Ni, Zhimin Zhai

01.12.2017 | Review | Ausgabe 1/2017 Open Access

XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy

Vincent Camus, Hadjer Miloudi, Antoine Taly, Brigitte Sola, Fabrice Jardin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer

Fuzhen Qi, Xianghua Liu, Hao Wu, Xiang Yu, Chenchen Wei, Xiaodan Huang, Guozhong Ji, Fengqi Nie, Keming Wang

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Genetic alterations of m6A regulators predict poorer survival in acute myeloid leukemia

Chau-To Kwok, Amy D. Marshall, John E. J. Rasko, Justin J. L. Wong

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Paxillin: a crossroad in pathological cell migration

Ana María López-Colomé, Irene Lee-Rivera, Regina Benavides-Hidalgo, Edith López

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Molecular and genetic alterations associated with therapy resistance and relapse of acute myeloid leukemia

Hubert Hackl, Ksenia Astanina, Rotraud Wieser

01.12.2017 | Research | Ausgabe 1/2017 Open Access

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

Jian Zheng, Xiaobai Liu, Yixue Xue, Wei Gong, Jun Ma, Zhuo Xi, Zhongyou Que, Yunhui Liu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

New development in CAR-T cell therapy

Zhenguang Wang, Zhiqiang Wu, Yang Liu, Weidong Han

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera

Federico Lussana, Alessandra Carobbio, Silvia Salmoiraghi, Paola Guglielmelli, Alessandro Maria Vannucchi, Barbara Bottazzi, Roberto Leone, Alberto Mantovani, Tiziano Barbui, Alessandro Rambaldi

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long-term treatment with ruxolitinib for patients with myelofibrosis: 5-year update from the randomized, double-blind, placebo-controlled, phase 3 COMFORT-I trial

Srdan Verstovsek, Ruben A. Mesa, Jason Gotlib, Vikas Gupta, John F. DiPersio, John V. Catalano, Michael W. N. Deininger, Carole B. Miller, Richard T. Silver, Moshe Talpaz, Elliott F. Winton, Jimmie H. Harvey Jr., Murat O. Arcasoy, Elizabeth O. Hexner, Roger M. Lyons, Ronald Paquette, Azra Raza, Mark Jones, Deanna Kornacki, Kang Sun, Hagop Kantarjian, for the COMFORT-I investigators

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Mesenchymal stromal cells as vehicles of tetravalent bispecific Tandab (CD3/CD19) for the treatment of B cell lymphoma combined with IDO pathway inhibitor d-1-methyl-tryptophan

Xiaolong Zhang, Yuanyuan Yang, Leisheng Zhang, Yang Lu, Qing Zhang, Dongmei Fan, Yizhi Zhang, Yanjun Zhang, Zhou Ye, Dongsheng Xiong

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Extracellular vesicles-mediated noncoding RNAs transfer in cancer

Pei Ma, Yutian Pan, Wei Li, Chongqi Sun, Jie Liu, Tongpeng Xu, Yongqian Shu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Tumor-associated macrophages: from basic research to clinical application

Li Yang, Yi Zhang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Metformin potentiates the effect of arsenic trioxide suppressing intrahepatic cholangiocarcinoma: roles of p38 MAPK, ERK3, and mTORC1

Sunbin Ling, Haiyang Xie, Fan Yang, Qiaonan Shan, Haojiang Dai, Jianyong Zhuo, Xuyong Wei, Penghong Song, Lin Zhou, Xiao Xu, Shusen Zheng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Ovatodiolide suppresses colon tumorigenesis and prevents polarization of M2 tumor-associated macrophages through YAP oncogenic pathways

Yan-Jiun Huang, Ching-Kuo Yang, Po-Li Wei, Thanh-Tuan Huynh, Jacqueline Whang-Peng, Tzu-Ching Meng, Michael Hsiao, Yew-Ming Tzeng, Alexander TH Wu, Yun Yen

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Spectrum of somatic mutations detected by targeted next-generation sequencing and their prognostic significance in adult patients with acute lymphoblastic leukemia

Juan Feng, Yan Li, Yujiao Jia, Qiuyun Fang, Xiaoyuan Gong, Xiaobao Dong, Kun Ru, Qinghua Li, Xingli Zhao, Kaiqi Liu, Min Wang, Zheng Tian, Yannan Jia, Ying Wang, Dong Lin, Hui Wei, Kejing Tang, Yingchang Mi, Jianxiang Wang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Uncovering the roles of long non-coding RNAs in cancer stem cells

Xiaoxing Huang, Ruijing Xiao, Shan Pan, Xiangyong Yang, Wen Yuan, Zhenbo Tu, Ming Xu, Yufan Zhu, Qian Yin, Yingjie Wu, Weidong Hu, Liang Shao, Jie Xiong, Qiuping Zhang

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

A hybrid of B and T lymphoblastic cell line could potentially substitute dendritic cells to efficiently expand out Her-2/neu-specific cytotoxic T lymphocytes from advanced breast cancer patients in vitro

Sheng Chen, Feifei Gu, Kang Li, Kai Zhang, Yangyang Liu, Jinyan Liang, Wei Gao, Gang Wu, Li Liu

01.12.2017 | Case report | Ausgabe 1/2017 Open Access

Severe nivolumab-induced pneumonitis preceding durable clinical remission in a patient with refractory, metastatic lung squamous cell cancer: a case report

Hong Li, Weijie Ma, Ken Y. Yoneda, Elizabeth H. Moore, Yanhong Zhang, Lee L. Q. Pu, Garrett M. Frampton, Michael Molmen, Philip J. Stephens, Tianhong Li

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Mutational profiling of acute lymphoblastic leukemia with testicular relapse

Ling-Wen Ding, Qiao-Yang Sun, Anand Mayakonda, Kar-Tong Tan, Wenwen Chien, De-Chen Lin, Yan-Yi Jiang, Liang Xu, Manoj Garg, Zhen-Tang Lao, Michael Lill, Henry Yang, Allen Eng Juh Yeoh, H. Phillip Koeffler

01.12.2017 | Review | Ausgabe 1/2017 Open Access

T-ALL and thymocytes: a message of noncoding RNAs

Annelynn Wallaert, Kaat Durinck, Tom Taghon, Pieter Van Vlierberghe, Frank Speleman

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

Go J. Yoshida

01.12.2017 | Rapid communication | Ausgabe 1/2017 Open Access

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

Le Qin, Yunxin Lai, Ruocong Zhao, Xinru Wei, Jianyu Weng, Peilong Lai, Baiheng Li, Simiao Lin, Suna Wang, Qiting Wu, Qiubin Liang, Yangqiu Li, Xuchao Zhang, Yilong Wu, Pentao Liu, Yao Yao, Duanqing Pei, Xin Du, Peng Li

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Chidamide in relapsed or refractory peripheral T cell lymphoma: a multicenter real-world study in China

Yuankai Shi, Bo Jia, Wei Xu, Wenyu Li, Ting Liu, Peng Liu, Weili Zhao, Huilai Zhang, Xiuhua Sun, Haiyan Yang, Xi Zhang, Jie Jin, Zhengming Jin, Zhiming Li, Lugui Qiu, Mei Dong, Xiaobing Huang, Yi Luo, Xiaodong Wang, Xin Wang, Jianqiu Wu, Jingyan Xu, Pingyong Yi, Jianfeng Zhou, Hongming He, Lin Liu, Jianzhen Shen, Xiaoqiong Tang, Jinghua Wang, Jianmin Yang, Qingshu Zeng, Zhihui Zhang, Zhen Cai, Xiequn Chen, Kaiyang Ding, Ming Hou, Huiqiang Huang, Xiaoling Li, Rong Liang, Qifa Liu, Yuqin Song, Hang Su, Yuhuan Gao, Lihong Liu, Jianmin Luo, Liping Su, Zimin Sun, Huo Tan, Huaqing Wang, Jingwen Wang, Shuye Wang, Hongyu Zhang, Xiaohong Zhang, Daobin Zhou, Ou Bai, Gang Wu, Liling Zhang, Yizhuo Zhang

01.12.2017 | Rapid communication | Ausgabe 1/2017 Open Access

Mutations of CREBBP and SOCS1 are independent prognostic factors in diffuse large B cell lymphoma: mutational analysis of the SAKK 38/07 prospective clinical trial cohort

Darius Juskevicius, David Jucker, Dirk Klingbiel, Christoph Mamot, Stephan Dirnhofer, Alexandar Tzankov

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

A novel melittin nano-liposome exerted excellent anti-hepatocellular carcinoma efficacy with better biological safety

Jie Mao, Shujun Liu, Min Ai, Zhuo Wang, Duowei Wang, Xianjing Li, Kaiyong Hu, Xinghua Gao, Yong Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Pterostilbene prevents AKT-ERK axis-mediated polymerization of surface fibronectin on suspended lung cancer cells independently of apoptosis and suppresses metastasis

Ying-Jan Wang, Jing-Fang Lin, Li-Hsin Cheng, Wen-Tsan Chang, Ying-Hsien Kao, Ming-Min Chang, Bour-Jr Wang, Hung-Chi Cheng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia

Saroj Vadhan-Raj, Rafat Abonour, Jonathan W. Goldman, David A. Smith, Christopher A. Slapak, Robert L. Ilaria Jr, Ramon V. Tiu, Xuejing Wang, Sophie Callies, Joanne Cox, Jay L. Tuttle, Yiu-Keung Lau, Eric J. Roeland

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study

Hangfei Fu, Nish Vadalia, Eric R. Xue, Candice Johnson, Luqiao Wang, William Y. Yang, Claudette Sanchez, Jun Nelson, Qian Chen, Eric T. Choi, Jian-Xing Ma, Jun Yu, Hong Wang, Xiaofeng Yang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The antiproliferative ELF2 isoform, ELF2B, induces apoptosis in vitro and perturbs early lymphocytic development in vivo

Fiona H. X. Guan, Charles G. Bailey, Cynthia Metierre, Patrick O’Young, Dadi Gao, Teh Liane Khoo, Jeff Holst, John E. J. Rasko

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The role of stromal cancer-associated fibroblasts in pancreatic cancer

Dagny von Ahrens, Tushar D. Bhagat, Deepak Nagrath, Anirban Maitra, Amit Verma

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The cell cycle checkpoint inhibitors in the treatment of leukemias

A. Ghelli Luserna di Rora’, I. Iacobucci, G. Martinelli

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Chimeric antigen receptor T cells: a novel therapy for solid tumors

Shengnan Yu, Anping Li, Qian Liu, Tengfei Li, Xun Yuan, Xinwei Han, Kongming Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Integrated analysis identifies microRNA-195 as a suppressor of Hippo-YAP pathway in colorectal cancer

Min Sun, Haibin Song, Shuyi Wang, Chunxiao Zhang, Liang Zheng, Fangfang Chen, Dongdong Shi, Yuanyuan Chen, Chaogang Yang, Zhenxian Xiang, Qing Liu, Chen Wei, Bin Xiong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Activity of the novel BCR kinase inhibitor IQS019 in preclinical models of B-cell non-Hodgkin lymphoma

P. Balsas, A. Esteve-Arenys, J. Roldán, L. Jiménez, V. Rodríguez, J. G. Valero, A. Chamorro-Jorganes, R. Puig de la Bellacasa, J. Teixidó, A. Matas-Céspedes, A. Moros, A. Martínez, E. Campo, A. Sáez-Borderías, J. I. Borrell, P. Pérez-Galán, D. Colomer, G. Roué

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Blocking the PD-1/PD-L1 pathway in glioma: a potential new treatment strategy

Song Xue, Man Hu, Veena Iyer, Jinming Yu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

Shikhar Mehrotra, Carolyn D. Britten, Steve Chin, Elizabeth Garrett-Mayer, Colleen A. Cloud, Mingli Li, Gina Scurti, Mohamed L. Salem, Michelle H. Nelson, Melanie B. Thomas, Chrystal M. Paulos, Andres M. Salazar, Michael I. Nishimura, Mark P. Rubinstein, Zihai Li, David J. Cole

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Next-generation sequencing and FISH studies reveal the appearance of gene mutations and chromosomal abnormalities in hematopoietic progenitors in chronic lymphocytic leukemia

Miguel Quijada-Álamo, María Hernández-Sánchez, Cristina Robledo, Jesús-María Hernández-Sánchez, Rocío Benito, Adrián Montaño, Ana E. Rodríguez-Vicente, Dalia Quwaider, Ana-África Martín, María García-Álvarez, María Jesús Vidal-Manceñido, Gonzalo Ferrer-Garrido, María-Pilar Delgado-Beltrán, Josefina Galende, Juan-Nicolás Rodríguez, Guillermo Martín-Núñez, José-María Alonso, Alfonso García de Coca, José A. Queizán, Magdalena Sierra, Carlos Aguilar, Alexander Kohlmann, José-Ángel Hernández, Marcos González, Jesús-María Hernández-Rivas

01.12.2017 | Rapid communication | Ausgabe 1/2017 Open Access

Activity of trabectedin and the PARP inhibitor rucaparib in soft-tissue sarcomas

Audrey Laroche, Vanessa Chaire, François Le Loarer, Marie-Paule Algéo, Christophe Rey, Kevin Tran, Carlo Lucchesi, Antoine Italiano

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The diagnosis and management of NK/T-cell lymphomas

Eric Tse, Yok-Lam Kwong

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of modern immunotherapy in gastrointestinal malignancies: a review of current clinical progress

Zin W. Myint, Gaurav Goel

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The next generation of immunotherapy: keeping lung cancer in check

Ashwin Somasundaram, Timothy F. Burns

01.12.2017 | Review | Ausgabe 1/2017 Open Access

The use of immunotherapy in the treatment of melanoma

Tala Achkar, Ahmad A. Tarhini

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Posttranslationally modified progesterone receptors direct ligand-specific expression of breast cancer stem cell-associated gene programs

Todd P. Knutson, Thu H. Truong, Shihong Ma, Nicholas J. Brady, Megan E. Sullivan, Ganesh Raj, Kathryn L. Schwertfeger, Carol A. Lange

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Characterization and risk estimate of cancer in patients with primary Sjögren syndrome

Pilar Brito-Zerón, Belchin Kostov, Guadalupe Fraile, Daniel Caravia-Durán, Brenda Maure, Francisco-Javier Rascón, Mónica Zamora, Arnau Casanovas, Miguel Lopez-Dupla, Mar Ripoll, Blanca Pinilla, Eva Fonseca, Miriam Akasbi, Gloria de la Red, Miguel-Angel Duarte-Millán, Patricia Fanlo, Pablo Guisado-Vasco, Roberto Pérez-Alvarez, Antonio J. Chamorro, César Morcillo, Iratxe Jiménez-Heredia, Isabel Sánchez-Berná, Armando López-Guillermo, Manuel Ramos-Casals, on behalf of the SS Study Group GEAS-SEMI

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A novel lncRNA uc.134 represses hepatocellular carcinoma progression by inhibiting CUL4A-mediated ubiquitination of LATS1

Wen Ni, Yuqin Zhang, Zetao Zhan, Feng Ye, Yonghao Liang, Jing Huang, Keli Chen, Longhua Chen, Yi Ding

01.12.2017 | Research | Ausgabe 1/2017 Open Access

DEPTOR maintains plasma cell differentiation and favorably affects prognosis in multiple myeloma

Dalia Quwaider, Luis A. Corchete, Irena Misiewicz-Krzeminska, María E. Sarasquete, José J. Pérez, Patryk Krzeminski, Noemí Puig, María Victoria Mateos, Ramón García-Sanz, Ana B. Herrero, Norma C. Gutiérrez

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Emerging therapies for acute myeloid leukemia

Caner Saygin, Hetty E. Carraway

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Immunotherapy in hematologic malignancies: past, present, and future

Annie Im, Steven Z. Pavletic

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Immunotherapy in genitourinary malignancies

Kathan Mehta, Keyur Patel, Rahul A. Parikh

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

Recent advances in cancer immunotherapy

Weijing Sun

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Recent advances of highly selective CDK4/6 inhibitors in breast cancer

Hanxiao Xu, Shengnan Yu, Qian Liu, Xun Yuan, Sridhar Mani, Richard G. Pestell, Kongming Wu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Emerging therapies for breast cancer

Xichun Hu, Wei Huang, Minhao Fan

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

Meng Yang, Umit Topaloglu, W. Jeffrey Petty, Matthew Pagni, Kristie L. Foley, Stefan C. Grant, Mac Robinson, Rhonda L. Bitting, Alexandra Thomas, Angela T. Alistar, Rodwige J. Desnoyers, Michael Goodman, Carol Albright, Mercedes Porosnicu, Mihaela Vatca, Shadi A. Qasem, Barry DeYoung, Ville Kytola, Matti Nykter, Kexin Chen, Edward A. Levine, Edgar D. Staren, Ralph B. D’Agostino Jr, Robin M. Petro, William Blackstock, Bayard L. Powell, Edward Abraham, Boris Pasche, Wei Zhang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Wnt/beta-catenin pathway: modulating anticancer immune response

Sachin Gopalkrishna Pai, Benedito A. Carneiro, Jose Mauricio Mota, Ricardo Costa, Caio Abner Leite, Romualdo Barroso-Sousa, Jason Benjamin Kaplan, Young Kwang Chae, Francis Joseph Giles

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Curative or pre-emptive adenovirus-specific T cell transfer from matched unrelated or third party haploidentical donors after HSCT, including UCB transplantations: a successful phase I/II multicenter clinical trial

Chongsheng Qian, Arnaud Campidelli, Yingying Wang, Huili Cai, Véronique Venard, Hélène Jeulin, Jean Hugues Dalle, Cécile Pochon, Maud D’aveni, Benedicte Bruno, Catherine Paillard, Stéphane Vigouroux, Charlotte Jubert, Patrice Ceballos, Aude Marie-Cardine, Claire Galambrun, Clément Cholle, Isabelle Clerc Urmes, Nadine Petitpain, Marcelo De Carvalho Bittencourt, Véronique Decot, Loïc Reppel, Alexandra Salmon, Laurence Clement, Danièle Bensoussan

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Checkpoint inhibitors in hematological malignancies

Chi Young Ok, Ken H. Young

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial

Mei-feng Li, Xiao-li Li, Kai-liang Fan, Ying-yi Yu, Jing Gong, Shu-ying Geng, Ya-feng Liang, Ling Huang, Ji-hua Qiu, Xing-han Tian, Wen-ting Wang, Xiao-lu Zhang, Qing-xia Yu, Yuan-feng Zhang, Peng Lin, Li-na Wang, Xin Li, Ming Hou, Lu-yi Liu, Jun Peng

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Anti-claudin 18.2 antibody as new targeted therapy for advanced gastric cancer

Prabhsimranjot Singh, Sudhamshi Toom, Yiwu Huang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Current status and perspectives of patient-derived xenograft models in cancer research

Yunxin Lai, Xinru Wei, Shouheng Lin, Le Qin, Lin Cheng, Peng Li

01.12.2017 | Research | Ausgabe 1/2017 Open Access

An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets

Katherine E. Hill, Andrew D. Kelly, Marieke L. Kuijjer, William Barry, Ahmed Rattani, Cassandra C. Garbutt, Haydn Kissick, Katherine Janeway, Antonio Perez-Atayde, Jeffrey Goldsmith, Mark C. Gebhardt, Mohamed S. Arredouani, Greg Cote, Francis Hornicek, Edwin Choy, Zhenfeng Duan, John Quackenbush, Benjamin Haibe-Kains, Dimitrios Spentzos

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Incorporation of high-dose 131I-metaiodobenzylguanidine treatment into tandem high-dose chemotherapy and autologous stem cell transplantation for high-risk neuroblastoma: results of the SMC NB-2009 study

Ji Won Lee, Sanghoon Lee, Hee Won Cho, Youngeun Ma, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo, Eun Joo Cho, Suk-Koo Lee, Do Hoon Lim

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Intrathymic injection of hematopoietic progenitor cells establishes functional T cell development in a mouse model of severe combined immunodeficiency

Andrea Z. Tuckett, Raymond H. Thornton, Richard J. O’Reilly, Marcel R. M. van den Brink, Johannes L. Zakrzewski

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Clinical applications of PD-L1 bioassays for cancer immunotherapy

Delong Liu, Shuhang Wang, Wendy Bindeman

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The chimeric monoclonal antibody MHCSZ-123 against human von Willebrand factor A3 domain inhibits high-shear arterial thrombosis in a Rhesus monkey model

Shundong Ji, Miao Jiang, Bin Yan, Fei Shen, Yang He, Aini Wan, Lijun Xia, Changgeng Ruan, Yiming Zhao

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia

Manoj K. Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin Lindquist, Rolla Yafawi, Michael Y. Choi, Ale-Ali Amine, Laura Z. Rassenti, Cathy Zhang, Shu-Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Nicole Santoro, Annalisa Ruggeri, Myriam Labopin, Andrea Bacigalupo, Fabio Ciceri, Zafer Gülbaş, He Huang, Boris Afanasyev, William Arcese, Depei Wu, Yener Koc, Johanna Tischer, Stella Santarone, Sebastian Giebel, Mohamad Mohty, Arnon Nagler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The Gαh-PLCδ1 signaling axis drives metastatic progression in triple-negative breast cancer

Shang-Pen Huang, Pei-Yao Liu, Chih-Jung Kuo, Chi-Long Chen, Wei-Jiunn Lee, Yu-Hui Tsai, Yuan-Feng Lin

01.12.2017 | Research | Ausgabe 1/2017 Open Access

SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B

Zhibin Yu, Yingnan Sun, Xiaoling She, Zeyou Wang, Shuai Chen, Zhiyong Deng, Yan Zhang, Qiang Liu, Qing Liu, Chunhua Zhao, Peiyao Li, Changhong Liu, Jianbo Feng, Haijuan Fu, Guiyuan Li, Minghua Wu

01.12.2017 | Letter to the Editor | Ausgabe 1/2017 Open Access

T cells bearing anti-CD19 and/or anti-CD38 chimeric antigen receptors effectively abrogate primary double-hit lymphoma cells

Keichiro Mihara, Tetsumi Yoshida, Yoshifumi Takei, Naomi Sasaki, Yoshihiro Takihara, Junya Kuroda, Tatsuo Ichinohe

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Rituximab-containing reduced-intensity conditioning improves progression-free survival following allogeneic transplantation in B cell non-Hodgkin lymphoma

Narendranath Epperla, Kwang Woo Ahn, Sairah Ahmed, Madan Jagasia, Alyssa DiGilio, Steven M. Devine, Samantha Jaglowski, Vanessa Kennedy, Andrew R. Rezvani, Sonali M. Smith, Anna Sureda, Timothy S. Fenske, Mohamed A. Kharfan-Dabaja, Phillipe Armand, Mehdi Hamadani

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Augmentation of the anticancer activity of CYT997 in human prostate cancer by inhibiting Src activity

Yong Teng, Yafei Cai, Wenhu Pi, Lixia Gao, Chloe Shay

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Cellular function reinstitution of offspring red blood cells cloned from the sickle cell disease patient blood post CRISPR genome editing

Jianguo Wen, Wenjing Tao, Suyang Hao, Youli Zu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interleukin-21 promotes thymopoiesis recovery following hematopoietic stem cell transplantation

Aurélie Tormo, Fatemeh Khodayarian, Yun Cui, Edouard Al-Chami, Reem Kanjarawi, Beatriz Noé, Huijie Wang, Moutih Rafei

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of epigenetics-microRNA axis in drug resistance of multiple myeloma

Nasrin Rastgoo, Jahangir Abdi, Jian Hou, Hong Chang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases

Melissa García-Caballero, Jenny Paupert, Silvia Blacher, Maureen Van de Velde, Ana Rodríguez Quesada, Miguel Angel Medina, Agnès Noël

01.12.2017 | Rapid communication | Ausgabe 1/2017 Open Access

Combined targeting of MDM2 and CDK4 is synergistic in dedifferentiated liposarcomas

Audrey Laroche-Clary, Vanessa Chaire, Marie-Paule Algeo, Marie-Alix Derieppe, François L. Loarer, Antoine Italiano

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Blimp-1 impairs T cell function via upregulation of TIGIT and PD-1 in patients with acute myeloid leukemia

Liuluan Zhu, Yaxian Kong, Jianhong Zhang, David F. Claxton, W. Christopher Ehmann, Witold B. Rybka, Neil D. Palmisiano, Ming Wang, Bei Jia, Michael Bayerl, Todd D. Schell, Raymond J. Hohl, Hui Zeng, Hong Zheng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway

Chun-Hua Wei, Gang Wu, Qian Cai, Xi-Can Gao, Fan Tong, Rui Zhou, Rui-Guang Zhang, Ji-Hua Dong, Yu Hu, Xiao-Rong Dong

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes

Michela Sica, Tommaso Rondelli, Patrizia Ricci, Maria De Angioletti, Antonio M. Risitano, Rosario Notaro

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Single- or double-unit UCBT following RIC in adults with AL: a report from Eurocord, the ALWP and the CTIWP of the EBMT

Frédéric Baron, Annalisa Ruggeri, Eric Beohou, Myriam Labopin, Mohamad Mohty, Didier Blaise, Jan J Cornelissen, Patrice Chevallier, Guillermo Sanz, Eefke Petersen, Bipin N Savani, Eliane Gluckman, Arnon Nagler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients

Marzia Vezzalini, Andrea Mafficini, Luisa Tomasello, Erika Lorenzetto, Elisabetta Moratti, Zeno Fiorini, Tessa L. Holyoake, Francesca Pellicano, Mauro Krampera, Cristina Tecchio, Mohamed Yassin, Nader Al-Dewik, Mohamed A. Ismail, Ali Al Sayab, Maria Monne, Claudio Sorio

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Comparison of matched sibling donors versus unrelated donors in allogeneic stem cell transplantation for primary refractory acute myeloid leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT

Eolia Brissot, Myriam Labopin, Matthias Stelljes, Gerhard Ehninger, Rainer Schwerdtfeger, Jürgen Finke, Hans-Jochem Kolb, Arnold Ganser, Kerstin Schäfer-Eckart, Axel R. Zander, Donald Bunjes, Stephan Mielke, Wolfgang A. Bethge, Noël Milpied, Peter Kalhs, Igor-Woflgang Blau, Nicolaus Kröger, Antonin Vitek, Martin Gramatzki, Ernst Holler, Christoph Schmid, Jordi Esteve, Mohamad Mohty, Arnon Nagler

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Clinical characteristics and outcomes according to age in lenalidomide-treated patients with RBC transfusion-dependent lower-risk MDS and del(5q)

Pierre Fenaux, Aristoteles Giagounidis, Dominik Selleslag, Odile Beyne-Rauzy, Moshe Mittelman, Petra Muus, Stephen D. Nimer, Eva Hellström-Lindberg, Bayard L. Powell, Agnes Guerci-Bresler, Mikkael A. Sekeres, H. Joachim Deeg, Consuelo del Cañizo, Peter L. Greenberg, Jamile M. Shammo, Barry Skikne, Xujie Yu, Alan F. List

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

Yujia Xu, Zubin Zhang, Jie Li, Jiefei Tong, Biyin Cao, Paul Taylor, Xiaowen Tang, Depei Wu, Michael F. Moran, Yuanying Zeng, Xinliang Mao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

MDM2/X inhibitors under clinical evaluation: perspectives for the management of hematological malignancies and pediatric cancer

Veronica Tisato, Rebecca Voltan, Arianna Gonelli, Paola Secchiero, Giorgio Zauli

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Haploidentical allograft is superior to matched sibling donor allograft in eradicating pre-transplantation minimal residual disease of AML patients as determined by multiparameter flow cytometry: a retrospective and prospective analysis

Ying-Jun Chang, Yu Wang, Yan-Rong Liu, Lan-Ping Xu, Xiao-Hui Zhang, Huan Chen, Yu-Hong Chen, Feng-Rong Wang, Wei Han, Yu-Qian Sun, Chen-Hua Yan, Fei-Fei Tang, Xiao-Dong Mo, Kai-Yan Liu, Xiao-Jun Huang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Superior GVHD-free, relapse-free survival for G-BM to G-PBSC grafts is associated with higher MDSCs content in allografting for patients with acute leukemia

Qian Fan, Hui Liu, Xinquan Liang, Ting Yang, Zhiping Fan, Fen Huang, Yiwen Ling, Xin Liao, Li Xuan, Na Xu, Xiaojun Xu, Jieyu Ye, Qifa Liu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Ongoing clinical trials of PD-1 and PD-L1 inhibitors for lung cancer in China

Si-Yang Liu, Yi-Long Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Randomized, double-blind, placebo-controlled phase III study of ixazomib plus lenalidomide-dexamethasone in patients with relapsed/refractory multiple myeloma: China Continuation study

Jian Hou, Jie Jin, Yan Xu, Depei Wu, Xiaoyan Ke, Daobin Zhou, Jin Lu, Xin Du, Xiequn Chen, Junmin Li, Jing Liu, Neeraj Gupta, Michael J. Hanley, Hongmei Li, Zhaowei Hua, Bingxia Wang, Xiaoquan Zhang, Hui Wang, Helgi van de Velde, Paul G. Richardson, Philippe Moreau

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

Jianbiao Zhou, Chonglei Bi, Ying Qing Ching, Jing-Yuan Chooi, Xiao Lu, Jessie Yiying Quah, Sabrina Hui-Min Toh, Zit-Liang Chan, Tuan Zea Tan, Phyllis SY Chong, Wee-Joo Chng

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The distinct biological implications of Asxl1 mutation and its roles in leukemogenesis revealed by a knock-in mouse model

Yueh-Chwen Hsu, Yu-Chiao Chiu, Chien-Chin Lin, Yuan-Yeh Kuo, Hsin-An Hou, Yi-Shiuan Tzeng, Chein-Jun Kao, Po-Han Chuang, Mei-Hsuan Tseng, Tzu-Hung Hsiao, Wen-Chien Chou, Hwei-Fang Tien

01.12.2017 | Research | Ausgabe 1/2017 Open Access

miR-380-5p-mediated repression of TEP1 and TSPYL5 interferes with telomerase activity and favours the emergence of an “ALT-like” phenotype in diffuse malignant peritoneal mesothelioma cells

Graziella Cimino-Reale, Paolo Gandellini, Francesca Santambrogio, Marta Recagni, Nadia Zaffaroni, Marco Folini

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Metabolism-associated danger signal-induced immune response and reverse immune checkpoint-activated CD40+ monocyte differentiation

Jin Dai, Pu Fang, Jason Saredy, Hang Xi, Cueto Ramon, William Yang, Eric T. Choi, Yong Ji, Wei Mao, Xiaofeng Yang, Hong Wang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Recent developments in immunotherapy of acute myeloid leukemia

Felix S. Lichtenegger, Christina Krupka, Sascha Haubner, Thomas Köhnke, Marion Subklewe

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2

Ming-de Huang, Wen-ming Chen, Fu-zhen Qi, Rui Xia, Ming Sun, Tong-peng Xu, Li Yin, Er-bao Zhang, Wei De, Yong-qian Shu

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Drug-induced amino acid deprivation as strategy for cancer therapy

Marcus Kwong Lam Fung, Godfrey Chi-Fung Chan

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Syk inhibitors in clinical development for hematological malignancies

Delong Liu, Aleksandra Mamorska-Dyga

01.12.2017 | Review | Ausgabe 1/2017 Open Access

PD-1/PD-L blockade in gastrointestinal cancers: lessons learned and the road toward precision immunotherapy

Junyu Long, Jianzhen Lin, Anqiang Wang, Liangcai Wu, Yongchang Zheng, Xiaobo Yang, Xueshuai Wan, Haifeng Xu, Shuguang Chen, Haitao Zhao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Clinical trials of tyrosine kinase inhibitors for lung cancer in China: a review

Shan Su, Yi-Long Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Transcriptome sequencing in pediatric acute lymphoblastic leukemia identifies fusion genes associated with distinct DNA methylation profiles

Yanara Marincevic-Zuniga, Johan Dahlberg, Sara Nilsson, Amanda Raine, Sara Nystedt, Carl Mårten Lindqvist, Eva C. Berglund, Jonas Abrahamsson, Lucia Cavelier, Erik Forestier, Mats Heyman, Gudmar Lönnerholm, Jessica Nordlund, Ann-Christine Syvänen

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Treatment of localized gastric and gastroesophageal adenocarcinoma: the role of accurate staging and preoperative therapy

Brian Badgwell, Prajnan Das, Jaffer Ajani

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Novel immunotherapies for adult patients with B-lineage acute lymphoblastic leukemia

Guoqing Wei, Jiasheng Wang, He Huang, Yanmin Zhao

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia

Mingxue Fan, Minghao Li, Lipeng Gao, Sicong Geng, Jing Wang, Yiting Wang, Zhiqiang Yan, Lei Yu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

Eddy C. Hsueh, James R. DeBloom, Jonathan Lee, Jeffrey J. Sussman, Kyle R. Covington, Brooke Middlebrook, Clare Johnson, Robert W. Cook, Craig L. Slingluff Jr, Kelly M. McMasters

01.12.2017 | Short report | Ausgabe 1/2017 Open Access

Early presence of anti-angiogenesis-related adverse events as a potential biomarker of antitumor efficacy in metastatic gastric cancer patients treated with apatinib: a cohort study

Xinyang Liu, Shukui Qin, Zhichao Wang, Jianming Xu, Jianping Xiong, Yuxian Bai, Zhehai Wang, Yan Yang, Guoping Sun, Liwei Wang, Leizhen Zheng, Nong Xu, Ying Cheng, Weijian Guo, Hao Yu, Tianshu Liu, Pagona Lagiou, Jin Li

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Romidepsin for the treatment of relapsed/refractory peripheral T cell lymphoma: prolonged stable disease provides clinical benefits for patients in the pivotal trial

Francine Foss, Steven Horwitz, Barbara Pro, H. Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson, Bertrand Coiffier

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Recent advances of bispecific antibodies in solid tumors

Shengnan Yu, Anping Li, Qian Liu, Xun Yuan, Hanxiao Xu, Dechao Jiao, Richard G. Pestell, Xinwei Han, Kongming Wu

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Long-term survival in patients treated with ruxolitinib for myelofibrosis: COMFORT-I and -II pooled analyses

Srdan Verstovsek, Jason Gotlib, Ruben A. Mesa, Alessandro M. Vannucchi, Jean-Jacques Kiladjian, Francisco Cervantes, Claire N. Harrison, Ronald Paquette, William Sun, Ahmad Naim, Peter Langmuir, Tuochuan Dong, Prashanth Gopalakrishna, Vikas Gupta

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways

Sabrina Manni, Marilena Carrino, Francesco Piazza

01.12.2017 | Research | Ausgabe 1/2017 Open Access

Association of a novel point mutation in MSH2 gene with familial multiple primary cancers

Hai Hu, Hong Li, Feng Jiao, Ting Han, Meng Zhuo, Jiujie Cui, Yixue Li, Liwei Wang

01.12.2017 | Research | Ausgabe 1/2017 Open Access

The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis

Lina Yang, Li Liu, Hong Gao, Jaya Pratap Pinnamaneni, Deepthi Sanagasetti, Vivek P. Singh, Kai Wang, Megumi Mathison, Qianzi Zhang, Fengju Chen, Qianxing Mo, Todd Rosengart, Jianchang Yang

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Interim analysis of survival in a prospective, multi-center registry cohort of cutaneous melanoma tested with a prognostic 31-gene expression profile test

Eddy C. Hsueh, James R. DeBloom, Jonathan Lee, Jeffrey J. Sussman, Kyle R. Covington, Brooke Middlebrook, Clare Johnson, Robert W. Cook, Craig L. Slingluff Jr, Kelly M. McMasters

01.12.2017 | Research | Ausgabe 1/2017 Open Access

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01.12.2017 | Research | Ausgabe 1/2017 Open Access

An improved pre-clinical patient-derived liquid xenograft mouse model for acute myeloid leukemia

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Erratum to: MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis

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01.12.2017 | Review | Ausgabe 1/2017 Open Access

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01.12.2017 | Review | Ausgabe 1/2017 Open Access

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01.12.2017 | Research | Ausgabe 1/2017 Open Access

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