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Zeitschrift

Journal of Neuroinflammation

Journal of Neuroinflammation 1/2016

Ausgabe 1/2016

Inhaltsverzeichnis ( 307 Artikel )

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model

Do-Geun Kim, Antje Krenz, Leon E. Toussaint, Kirk J. Maurer, Sudie-Ann Robinson, Angela Yan, Luisa Torres, Margaret S. Bynoe

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interleukin-18 modulation in autism spectrum disorders

Rita Businaro, Mariangela Corsi, Gabriella Azzara, Tania Di Raimo, Giovanni Laviola, Emilia Romano, Lidia Ricci, Mauro Maccarrone, Eleonora Aronica, Andrea Fuso, Serafino Ricci

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Modeling leukocyte trafficking at the human blood-nerve barrier in vitro and in vivo geared towards targeted molecular therapies for peripheral neuroinflammation

Kelsey M. Greathouse, Steven P. Palladino, Chaoling Dong, Eric S. Helton, Eroboghene E. Ubogu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

Andrea F. N. Rosenberger, Tjado H. J. Morrema, Wouter H. Gerritsen, Elise S. van Haastert, Hripsime Snkhchyan, Riet Hilhorst, Annemieke J. M. Rozemuller, Philip Scheltens, Saskia M. van der Vies, Jeroen J. M. Hoozemans

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Depressive symptoms are associated with tumor necrosis factor alpha in systemic lupus erythematosus

Mariana Postal, Aline Tamires Lapa, Nailú Angélica Sinicato, Karina de Oliveira Peliçari, Fernando Augusto Peres, Lilian Tereza Lavras Costallat, Paula Teixeira Fernandes, Roberto Marini, Simone Appenzeller

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CXCL5 signaling is a shared pathway of neuroinflammation and blood–brain barrier injury contributing to white matter injury in the immature brain

Lin-Yu Wang, Yi-Fang Tu, Yung-Chieh Lin, Chao-Ching Huang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Post-CNS-inflammation expression of CXCL12 promotes the endogenous myelin/neuronal repair capacity following spontaneous recovery from multiple sclerosis-like disease

Rina Zilkha-Falb, Nathali Kaushansky, Naoto Kawakami, Avraham Ben-Nun

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway

Xiao-Li Li, Heng Li, Min Zhang, Hua Xu, Long-Tao Yue, Xin-Xin Zhang, Shan Wang, Cong-Cong Wang, Yan-Bin Li, Ying-Chun Dou, Rui-Sheng Duan

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

Mousumi Ghosh, Yong Xu, Damien D. Pearse

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuroprotective effects of bee venom phospholipase A2 in the 3xTg AD mouse model of Alzheimer’s disease

Minsook Ye, Hwan-Suck Chung, Chanju Lee, Moon Sik Yoon, A. Ram Yu, Jin Su Kim, Deok-Sang Hwang, Insop Shim, Hyunsu Bae

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Poly(I:C) increases the expression of mPGES-1 and COX-2 in rat primary microglia

Antonio Carlos Pinheiro de Oliveira, Nizar M. Yousif, Harsharan Singh Bhatia, Julia Hermanek, Michael Huell, Bernd L. Fiebich

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK

Duy-Khanh Dang, Eun-Joo Shin, Yunsung Nam, Sungwoo Ryoo, Ji Hoon Jeong, Choon-Gon Jang, Toshitaka Nabeshima, Jau-Shyong Hong, Hyoung-Chun Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Endogenous adaptation to low oxygen modulates T-cell regulatory pathways in EAE

Nilufer Esen, Vladimir Katyshev, Zakhar Serkin, Svetlana Katysheva, Paula Dore-Duffy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Acute versus chronic phase mechanisms in a rat model of CRPS

Tzuping Wei, Tian-Zhi Guo, Wen-Wu Li, Wade S. Kingery, John David Clark

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Tauopathy in transgenic (SHR72) rats impairs function of central noradrenergic system and promotes neuroinflammation

Boris Mravec, Katarina Lejavova, Peter Vargovic, Katarina Ondicova, Lubica Horvathova, Petr Novak, Georg Manz, Peter Filipcik, Michal Novak, Richard Kvetnansky

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

R. Zangari, E. R. Zanier, G. Torgano, A. Bersano, S. Beretta, E. Beghi, B. Casolla, N. Checcarelli, S. Lanfranconi, A. Maino, C. Mandelli, G. Micieli, F. Orzi, E. Picetti, M. Silvestrini, N. Stocchetti, B. Zecca, P. Garred, M. G. De Simoni, the LEPAS group

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)

Konstantin Glebov, Patrick Wunderlich, Ilker Karaca, Jochen Walter

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Myeloid dendritic cells are decreased in peripheral blood of Alzheimer’s disease patients in association with disease progression and severity of depressive symptoms

Antonio Ciaramella, Francesca Salani, Federica Bizzoni, Maria Donata Orfei, Carlo Caltagirone, Gianfranco Spalletta, Paola Bossù

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

Hank Cheng, David A. Davis, Sina Hasheminassab, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

Julien Couturier, Ilie-Cosmin Stancu, Olivier Schakman, Nathalie Pierrot, François Huaux, Pascal Kienlen-Campard, Ilse Dewachter, Jean-Noël Octave

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta

Ryan C. McCarthy, Dah-Yuu Lu, Ahmed Alkhateeb, Andrew M. Gardeck, Chih-Hao Lee, Marianne Wessling-Resnick

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1

Chaitanya Kurhade, Loreen Zegenhagen, Elvira Weber, Sharmila Nair, Kristin Michaelsen-Preusse, Julia Spanier, Nelson O Gekara, Andrea Kröger, Anna K Överby

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

Fengjiao Wu, Qiang Zou, Xiaodan Ding, Dongyan Shi, Xingxing Zhu, Weiguo Hu, Lixin Liu, Hong Zhou

01.12.2016 | Research | Ausgabe 1/2016 Open Access

RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalomyelitis

Jae-Kyung Lee, George T. Kannarkat, Jaegwon Chung, Hyun Joon Lee, Kareem L. Graham, Malú G. Tansey

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The extracellular matrix protein laminin-10 promotes blood–brain barrier repair after hypoxia and inflammation in vitro

Korakoch Kangwantas, Emmanuel Pinteaux, Jeffrey Penny

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage

Bo Ma, Jason Patrick Day, Harrison Phillips, Bryan Slootsky, Emanuela Tolosano, Sylvain Doré

01.12.2016 | Research | Ausgabe 1/2016 Open Access

HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis

Shalini Swaroop, Nabonita Sengupta, Amol Ratnakar Suryawanshi, Yogita K Adlakha, Anirban Basu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Suppression of LPS-induced tau hyperphosphorylation by serum amyloid A

Jin Liu, Ding Wang, Shu-Qin Li, Yang Yu, Richard D. Ye

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure

Daan R. M. G. Ophelders, Ruth Gussenhoven, Martin Lammens, Benno Küsters, Matthew W. Kemp, John P. Newnham, Matthew S. Payne, Suhas G. Kallapur, Allan H. Jobe, Luc J. Zimmermann, Boris W. Kramer, Tim G. A. M. Wolfs

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling

Michael J. Moravan, John A. Olschowka, Jacqueline P. Williams, M. Kerry O’Banion

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures

Catherine O’Sullivan, Anna Schubart, Anis K. Mir, Kumlesh K. Dev

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases

Moonhee Lee, Edith G. McGeer, Patrick L. McGeer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis

Ke Liao, Minglei Guo, Fang Niu, Lu Yang, Shannon E. Callen, Shilpa Buch

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes

Siew Ying Wong, Michelle G.K. Tan, William A. Banks, W.S. Fred Wong, Peter T.-H. Wong, Mitchell K.P. Lai

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-κB pathways in human retinal pigment epithelium

Lifei Tao, Yiguo Qiu, Xinyu Fu, Ru Lin, Chunyan Lei, Jiaming Wang, Bo Lei

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression

Maria Albanese, Sara Zagaglia, Doriana Landi, Laura Boffa, Carolina G. Nicoletti, Maria Grazia Marciani, Georgia Mandolesi, Girolama A. Marfia, Fabio Buttari, Francesco Mori, Diego Centonze

01.12.2016 | Research | Ausgabe 1/2016 Open Access

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function

Justin Rustenhoven, Miranda Aalderink, Emma L. Scotter, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, E. Scott Graham, Richard L. M. Faull, Maurice A. Curtis, Thomas I-H. Park, Mike Dragunow

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Macrophage depletion reduced brain injury following middle cerebral artery occlusion in mice

Yuanyuan Ma, Yaning Li, Lu Jiang, Liping Wang, Zhen Jiang, Yongting Wang, Zhijun Zhang, Guo-Yuan Yang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress

Jessica Hines-Beard, Wesley S. Bond, Jon R. Backstrom, Tonia S. Rex

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inflammatory cytokine and chemokine profiles are associated with patient outcome and the hyperadrenergic state following acute brain injury

Alex P. Di Battista, Shawn G. Rhind, Michael G. Hutchison, Syed Hassan, Maria Y. Shiu, Kenji Inaba, Jane Topolovec-Vranic, Antonio Capone Neto, Sandro B. Rizoli, Andrew J. Baker

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

Vicente Hernández-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-González, Michele Malaguarnera, Ana Agustí, Marta Llansola, Vicente Felipo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

Isaak Quast, Christian W. Keller, Patrick Weber, Christoph Schneider, Stephan von Gunten, Jan D. Lünemann

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model

Miriam Hernangómez, Ilona Klusáková, Marek Joukal, Ivana Hradilová-Svíženská, Carmen Guaza, Petr Dubový

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Bilateral neuroinflammatory processes in visual pathways induced by unilateral ocular hypertension in the rat

Anaïs Sapienza, Anne-Laure Raveu, Elodie Reboussin, Christophe Roubeix, Céline Boucher, Julie Dégardin, David Godefroy, William Rostène, Annabelle Reaux-Le Goazigo, Christophe Baudouin, Stéphane Melik Parsadaniantz

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The expression of the chemokine receptor CCR5 in tick-borne encephalitis

Sambor Grygorczuk, Joanna Osada, Miłosz Parczewski, Anna Moniuszko, Renata Świerzbińska, Maciej Kondrusik, Piotr Czupryna, Justyna Dunaj, Milena Dąbrowska, Sławomir Pancewicz

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis

Alice Valentin-Torres, Carine Savarin, David R. Hinton, Timothy W. Phares, Cornelia C. Bergmann, Stephen A. Stohlman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina

Nilisha Fernando, Riccardo Natoli, Krisztina Valter, Jan Provis, Matt Rutar

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dual roles of the adenosine A2a receptor in autoimmune neuroinflammation

J. Ingwersen, B. Wingerath, J. Graf, K. Lepka, M. Hofrichter, F. Schröter, F. Wedekind, A. Bauer, J. Schrader, H.-P. Hartung, T. Prozorovski, O. Aktas

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes

Jeffrey R. Liddell, Sarka Lehtonen, Clare Duncan, Velta Keksa-Goldsteine, Anna-Liisa Levonen, Gundars Goldsteins, Tarja Malm, Anthony R. White, Jari Koistinaho, Katja M. Kanninen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation

Minjuan Bian, Xiaoye Du, Jingang Cui, Peiwei Wang, Wenjian Wang, Weiliang Zhu, Teng Zhang, Yu Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Electroconvulsive therapy suppresses the neurotoxic branch of the kynurenine pathway in treatment-resistant depressed patients

Lilly Schwieler, Martin Samuelsson, Mark A. Frye, Maria Bhat, Ina Schuppe-Koistinen, Oscar Jungholm, Anette G. Johansson, Mikael Landén, Carl M. Sellgren, Sophie Erhardt

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Heme oxygenase-1 promotes neuron survival through down-regulation of neuronal NLRP1 expression after spinal cord injury

Wen-Ping Lin, Gong-Peng Xiong, Qing Lin, Xuan-Wei Chen, Li-Qun Zhang, Jin-Xing Shi, Qing-Feng Ke, Jian-Hua Lin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia

Yang Cai, Hong Kong, Yin-Bing Pan, Lai Jiang, Xiu-Xiu Pan, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

Joan W. Berman, Loreto Carvallo, Clarisa M. Buckner, Aimée Luers, Lisa Prevedel, Michael V. Bennett, Eliseo A. Eugenin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Anti-N-methyl-D-aspartate receptor encephalitis: the clinical course in light of the chemokine and cytokine levels in cerebrospinal fluid

Zuzana Liba, Jana Kayserova, Martin Elisak, Petr Marusic, Hana Nohejlova, Jitka Hanzalova, Vladimir Komarek, Anna Sediva

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

Yinquan Fang, Lemeng Yao, Chenhui Li, Jing Wang, Jianing Wang, Shujian Chen, Xin-fu Zhou, Hong Liao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

Rika Sakuma, Maiko Kawahara, Akiko Nakano-Doi, Ai Takahashi, Yasue Tanaka, Aya Narita, Sachi Kuwahara-Otani, Tetsu Hayakawa, Hideshi Yagi, Tomohiro Matsuyama, Takayuki Nakagomi

01.12.2016 | Reviewer acknowledgement | Ausgabe 1/2016 Open Access

Reviewer acknowledgement

Sue T Griffin, Robert E Mrak

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Reciprocal signals between microglia and neurons regulate α-synuclein secretion by exophagy through a neuronal cJUN-N-terminal kinase-signaling axis

Dan Ploug Christensen, Patrick Ejlerskov, Izabela Rasmussen, Frederik Vilhardt

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Potential role of microRNA-7 in the anti-neuroinflammation effects of nicorandil in astrocytes induced by oxygen-glucose deprivation

Yin-Feng Dong, Zheng-Zhen Chen, Zhan Zhao, Dan-Dan Yang, Hui Yan, Juan Ji, Xiu-Lan Sun

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Role of docosahexaenoic acid in the modulation of glial cells in Alzheimer’s disease

David Heras-Sandoval, José Pedraza-Chaverri, Jazmin M. Pérez-Rojas

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage

Chun-Hu Wu, Chien-Cheng Chen, Chai-You Lai, Tai-Ho Hung, Chao-Chang Lin, Min Chao, Szu-Fu Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

Ting-Ting Song, Yan-Hua Bi, Yu-Qi Gao, Rui Huang, Ke Hao, Gang Xu, Jia-Wei Tang, Zhi-Qiang Ma, Fan-Ping Kong, John H. Coote, Xue-Qun Chen, Ji-Zeng Du

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

John F. Bowyer, Sumit Sarkar, Karen M. Tranter, Joseph P. Hanig, Diane B. Miller, James P. O’Callaghan

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Microglial migration and interactions with dendrimer nanoparticles are altered in the presence of neuroinflammation

Fan Zhang, Elizabeth Nance, Yossef Alnasser, Rangaramanujam Kannan, Sujatha Kannan

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia

Tamjeed A. Siddiqui, Starlee Lively, Lyanne C. Schlichter

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research

Avinash Parimisetty, Anne-Claire Dorsemans, Rana Awada, Palaniyandi Ravanan, Nicolas Diotel, Christian Lefebvre d’Hellencourt

01.12.2016 | Case report | Ausgabe 1/2016 Open Access

Morvan’s syndrome and myasthenia gravis related to familial Mediterranean fever gene mutations

Junpei Koge, Shintaro Hayashi, Hiroyuki Murai, Jun Yokoyama, Yuri Mizuno, Taira Uehara, Naoyasu Ueda, Osamu Watanabe, Hiroshi Takashima, Jun-ichi Kira

01.12.2016 | Meeting report | Ausgabe 1/2016 Open Access

Glial cell biology in the Great Lakes region

Douglas L. Feinstein, Robert P. Skoff

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

Isabella Russo, Giulia Berti, Nicoletta Plotegher, Greta Bernardo, Roberta Filograna, Luigi Bubacco, Elisa Greggio

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Activation of the NLRP3 inflammasome in lipopolysaccharide-induced mouse fatigue and its relevance to chronic fatigue syndrome

Zi-Teng Zhang, Xiu-Ming Du, Xiu-Juan Ma, Ying Zong, Ji-Kuai Chen, Chen-Lin Yu, Yan-Gang Liu, Yong-Chun Chen, Li-Jun Zhao, Guo-Cai Lu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement activation at the motor end-plates in amyotrophic lateral sclerosis

Nawal Bahia El Idrissi, Sanne Bosch, Valeria Ramaglia, Eleonora Aronica, Frank Baas, Dirk Troost

01.12.2016 | Research | Ausgabe 1/2016 Open Access

B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus

Jing Wen, Jessica Doerner, Samantha Chalmers, Ariel Stock, Haowei Wang, Maria Gullinello, Mark J. Shlomchik, Chaim Putterman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology

Josefine R. Christiansen, Mads N. Olesen, Daniel E. Otzen, Marina Romero-Ramos, Vanesa Sanchez-Guajardo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Alessandra Cadete Martini, Temugin Berta, Stefânia Forner, Gang Chen, Allisson Freire Bento, Ru-Rong Ji, Giles Alexander Rae

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells

Chen-Yen Chung, Fang Liao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

Lin Yuan, Song Liu, Xuemei Bai, Yan Gao, Guangheng Liu, Xueer Wang, Dexiang Liu, Tong Li, Aijun Hao, Zhen Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

6-Mercaptopurine attenuates tumor necrosis factor-α production in microglia through Nur77-mediated transrepression and PI3K/Akt/mTOR signaling-mediated translational regulation

Hsin-Yi Huang, Hui-Fen Chang, Ming-Jen Tsai, Jhih-Si Chen, Mei-Jen Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses

Seong Bum Kim, Jin Young Choi, Erdenebileg Uyangaa, Ajit Mahadev Patil, Ferdaus Mohd Altaf Hossain, Jin Hur, Sang-Youel Park, John-Hwa Lee, Koanhoi Kim, Seong Kug Eo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury

Josh M. Morganti, Lara-Kirstie Riparip, Austin Chou, Sharon Liu, Nalin Gupta, Susanna Rosi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)

Felix Grassmann, Stuart Cantsilieris, Anja-Sabrina Schulz-Kuhnt, Stefan J. White, Andrea J Richardson, Alex W Hewitt, Brendan J. Vote, Denise Schmied, Robyn H Guymer, Bernhard H.F. Weber, Paul N. Baird

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma

Oliver W. Gramlich, Julia Teister, Mareike Neumann, Xue Tao, Sabine Beck, Harald D. von Pein, Norbert Pfeiffer, Franz H. Grus

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

Vicente Hernandez-Rabaza, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Alba Gonzalez-Usano, Ana Agusti, Tiziano Balzano, Marta Llansola, Vicente Felipo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

Yan-jing Yang, Liang Hu, Ye-peng Xia, Chun-yi Jiang, Chen Miao, Chun-qing Yang, Miao Yuan, Lin Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex

Fei-Ji Sun, Chun-Qing Zhang, Xin Chen, Yu-Jia Wei, Song Li, Shi-Yong Liu, Zhen-le Zang, Jiao-Jiang He, Wei Guo, Hui Yang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation

Gyun Jee Song, Myungsu Jung, Jong-Heon Kim, Hana Park, Md Habibur Rahman, Sheng Zhang, Zhong-Yin Zhang, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury

Lucy H. Funk, Amber R. Hackett, Mary Bartlett Bunge, Jae K. Lee

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury

Sangmi Lee, Aaron Mattingly, Amity Lin, Jeffrey Sacramento, Leda Mannent, Marie-Noelle Castel, Benoit Canolle, Sandrine Delbary-Gossart, Badia Ferzaz, Josh M. Morganti, Susanna Rosi, Adam R. Ferguson, Geoffrey T. Manley, Jacqueline C. Bresnahan, Michael S. Beattie

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis

Cornelia A. Deeg, Barbara Amann, Konstantin Lutz, Sieglinde Hirmer, Karina Lutterberg, Elisabeth Kremmer, Stefanie M. Hauck

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The effect of concomitant peripheral injury on traumatic brain injury pathobiology and outcome

Stuart J. McDonald, Mujun Sun, Denes V. Agoston, Sandy R. Shultz

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Methamphetamine alters microglial immune function through P2X7R signaling

Nicole C. Fernandes, Uma Sriram, Larisa Gofman, Jonathan M. Cenna, Servio H. Ramirez, Raghava Potula

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease

Kuan-I Lee, Hsueh-Te Lee, Hui-Ching Lin, Huey-Jen Tsay, Feng-Chuan Tsai, Song-Kun Shyue, Tzong-Shyuan Lee

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Retinal glial responses to optic nerve crush are attenuated in Bax-deficient mice and modulated by purinergic signaling pathways

Caitlin E. Mac Nair, Cassandra L. Schlamp, Angela D. Montgomery, Valery I. Shestopalov, Robert W. Nickells

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

A monoclonal natural human IgM protects axons in the absence of remyelination

Bharath Wootla, Aleksandar Denic, Arthur E. Warrington, Moses Rodriguez

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

Raffaella Moretti, Pierre-Louis Leger, Valérie C. Besson, Zsolt Csaba, Julien Pansiot, Lorena Di Criscio, Andrea Gentili, Luigi Titomanlio, Philippe Bonnin, Olivier Baud, Christiane Charriaut-Marlangue

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuron-immune mechanisms contribute to pain in early stages of arthritis

Francisco R. Nieto, Anna K. Clark, John Grist, Gareth J. Hathway, Victoria Chapman, Marzia Malcangio

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages

Ranran Han, Jinting Xiao, Hui Zhai, Junwei Hao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Alexandra K. Brooks, Marcus A. Lawson, Robin A. Smith, Tiffany M. Janda, Keith W. Kelley, Robert H. McCusker

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Takuya Iizumi, Shinichi Takahashi, Kyoko Mashima, Kazushi Minami, Yoshikane Izawa, Takato Abe, Takako Hishiki, Makoto Suematsu, Mayumi Kajimura, Norihiro Suzuki

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Differential expression of P2X7 receptor and IL-1β in nociceptive and neuropathic pain

Benjamin Luchting, Jens Heyn, Tobias Woehrle, Banafscheh Rachinger-Adam, Simone Kreth, Ludwig C Hinske, Shahnaz C Azad

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Interleukin-25 is detrimental for recovery after spinal cord injury in mice

Dearbhaile Dooley, Evi Lemmens, Peter Ponsaerts, Sven Hendrix

01.12.2016 | Research | Ausgabe 1/2016 Open Access

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain

Alison McColl, Carolyn A. Thomson, Louis Nerurkar, Gerard J. Graham, Jonathan Cavanagh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?

M. G. Frasch, M. Szynkaruk, A. P. Prout, K. Nygard, M. Cao, R. Veldhuizen, R. Hammond, B. S. Richardson

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Induction of the type I interferon response in neurological forms of Gaucher disease

Einat B. Vitner, Tamar Farfel-Becker, Natalia Santos Ferreira, Dena Leshkowitz, Piyush Sharma, Karl S. Lang, Anthony H. Futerman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia

Lekshmy Srinivas, Neetha N. Vellichirammal, Ann Mary Alex, Chandrasekharan Nair, Indu V. Nair, Moinak Banerjee

01.12.2016 | Retraction Note | Ausgabe 1/2016 Open Access

Retraction Note: Alteration of astrocytes and Wnt/β-catenin signaling in the frontal cortex of autistic subjects

Fujiang Cao, Ailan Yin, Guang Wen, Ashfaq M. Sheikh, Zujaja Tauqeer, Mazhar Malik, Amenah Nagori, Michael Schirripa, Frank Schirripa, George Merz, Shiqing Feng, W. Ted Brown, Xiaohong Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain

Kristen N. Fantetti, Erica L. Gray, Priya Ganesan, Apurva Kulkarni, Lauren A. O’Donnell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

Yvonne Couch, Alexander Trofimov, Natalyia Markova, Vladimir Nikolenko, Harry W. Steinbusch, Vladimir Chekhonin, Careen Schroeter, Klaus-Peter Lesch, Daniel C. Anthony, Tatyana Strekalova

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neonatal inflammatory pain and systemic inflammatory responses as possible environmental factors in the development of autism spectrum disorder of juvenile rats

Jin Hwan Lee, Alyssa R. Espinera, Dongdong Chen, Ko-Eun Choi, Asha Yoshiko Caslin, Soonmi Won, Valentina Pecoraro, Guang-Yin Xu, Ling Wei, Shan Ping Yu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Clozapine metabolites protect dopaminergic neurons through inhibition of microglial NADPH oxidase

Lulu Jiang, Xuefei Wu, Shuo Wang, Shih-Heng Chen, Hui Zhou, Belinda Wilson, Chun-Yang Jin, Ru-Band Lu, Keqin Xie, Qingshan Wang, Jau-Shyong Hong

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid

R. Marignier, A. Ruiz, S. Cavagna, A. Nicole, C. Watrin, M. Touret, S. Parrot, G. Malleret, C. Peyron, C. Benetollo, N. Auvergnon, S. Vukusic, P. Giraudon

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Early life overfeeding impairs spatial memory performance by reducing microglial sensitivity to learning

Simone N. De Luca, Ilvana Ziko, Luba Sominsky, Jason C. D. Nguyen, Tara Dinan, Alyson A. Miller, Trisha A. Jenkins, Sarah J. Spencer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cryopreserved vitamin D3-tolerogenic dendritic cells pulsed with autoantigens as a potential therapy for multiple sclerosis patients

María José Mansilla, Raian Contreras-Cardone, Juan Navarro-Barriuso, Nathalie Cools, Zwi Berneman, Cristina Ramo-Tello, Eva María Martínez-Cáceres

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Glial cell activation, recruitment, and survival of B-lineage cells following MCMV brain infection

James R. Lokensgard, Manohar B. Mutnal, Sujata Prasad, Wen Sheng, Shuxian Hu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase

Pablo Granados-Durán, María Dolores López-Ávalos, Timothy R. Hughes, Krista Johnson, B. Paul Morgan, Paul P. Tamburini, Pedro Fernández-Llebrez, Jesús M. Grondona

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells

Marie-Eve Tremblay, Issan Zhang, Kanchan Bisht, Julie C. Savage, Cynthia Lecours, Martin Parent, Vladimir Titorenko, Dusica Maysinger

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Brain trauma elicits non-canonical macrophage activation states

Charles C. Kim, Mary C. Nakamura, Christine L. Hsieh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy

C. M. Freria, D. Bernardes, G. L. Almeida, G. F. Simões, G. O. Barbosa, A. L. R. Oliveira

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke

Guoliang Yu, Ye Liang, Ziming Huang, Deron W. Jones, Kirkwood A. Pritchard Jr., Hao Zhang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity

Jerel A. Fields, Cassia Overk, Anthony Adame, Jazmin Florio, Michael Mante, Andrea Pineda, Paula Desplats, Edward Rockenstein, Cristian Achim, Eliezer Masliah

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Intraperitoneally administered IgG from patients with amyotrophic lateral sclerosis or from an immune-mediated goat model increase the levels of TNF-α, IL-6, and IL-10 in the spinal cord and serum of mice

Izabella Obál, Gergely Klausz, Yvette Mándi, Mária Deli, László Siklós, József I. Engelhardt

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inflammatory profile in LRRK2-associated prodromal and clinical PD

Kathrin Brockmann, Anja Apel, Claudia Schulte, Nicole Schneiderhan-Marra, Claustre Pont-Sunyer, Dolores Vilas, Javier Ruiz-Martinez, Markus Langkamp, Jean-Christophe Corvol, Florence Cormier, Thomas Knorpp, Thomas O. Joos, Thomas Gasser, Birgitt Schüle, Jan O. Aasly, Tatiana Foroud, Jose Felix Marti-Masso, Alexis Brice, Eduardo Tolosa, Connie Marras, Daniela Berg, Walter Maetzler

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Chronic administration of AMD3100 increases survival and alleviates pathology in SOD1G93A mice model of ALS

Inna Rabinovich-Nikitin, Assaf Ezra, Beka Barbiro, Polina Rabinovich-Toidman, Beka Solomon

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge

Jennifer M. Parrott, Laney Redus, Jason C. O’Connor

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Chronic spinal cord injury attenuates influenza virus-specific antiviral immunity

Valerie Bracchi-Ricard, Ji Zha, Annalise Smith, Darlah M. Lopez-Rodriguez, John R. Bethea, Samita Andreansky

01.12.2016 | Research | Ausgabe 1/2016 Open Access

STIMs and Orai1 regulate cytokine production in spinal astrocytes

Xinghua Gao, Jingsheng Xia, Frances M. Munoz, Melissa T. Manners, Rong Pan, Olimpia Meucci, Yue Dai, Huijuan Hu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Activated brain mast cells contribute to postoperative cognitive dysfunction by evoking microglia activation and neuronal apoptosis

Xiang Zhang, Hongquan Dong, Nana Li, Susu Zhang, Jie Sun, Shu Zhang, Yanning Qian

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: A new co-ultramicronized composite including palmitoylethanolamide and luteolin to prevent neuroinflammation in spinal cord injury

Irene Paterniti, Daniela Impellizzeri, Rosanna Di Paola, Michele Navarra, Salvatore Cuzzocrea, Emanuela Esposito

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain

Daniela Impellizzeri, Giuseppe Bruschetta, Marika Cordaro, Rosalia Crupi, Rosalba Siracusa, Emanuela Esposito, Salvatore Cuzzocrea

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia

David B. Kurland, Volodymyr Gerzanich, Jason K. Karimy, Seung Kyoon Woo, Rudi Vennekens, Marc Freichel, Bernd Nilius, Joseph Bryan, J. Marc Simard

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Reduced levels of alpha-1-antitrypsin in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a novel approach for a potential treatment

Uri Wormser, Jessica Mandrioli, Marco Vinceti, Nicola Fini, Amnon Sintov, Berta Brodsky, Elena Proskura, Yoram Finkelstein

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Endogenous analgesia mediated by CD4+ T lymphocytes is dependent on enkephalins in mice

Lilian Basso, Jérôme Boué, Karim Mahiddine, Catherine Blanpied, Sébastien Robiou-du-Pont, Nathalie Vergnolle, Céline Deraison, Gilles Dietrich

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Transgenic expression of non-structural genes of Theiler’s virus suppresses initial viral replication and pathogenesis of demyelination

Hyun Seok Kang, Jinjong Myoung, Eui Young So, Young Yil Bahk, Byung S. Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Reduction of cytosolic phospholipase A2α upregulation delays the onset of symptoms in SOD1G93A mouse model of amyotrophic lateral sclerosis

Yulia Solomonov, Nurit Hadad, Rachel Levy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Microglial immunophenotype in dementia with Alzheimer’s pathology

Thais Minett, John Classey, Fiona E. Matthews, Marie Fahrenhold, Mariko Taga, Carol Brayne, Paul G. Ince, James A. R. Nicoll, Delphine Boche, MRC CFAS

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pathways and gene networks mediating the regulatory effects of cannabidiol, a nonpsychoactive cannabinoid, in autoimmune T cells

Ewa Kozela, Ana Juknat, Fuying Gao, Nathali Kaushansky, Giovanni Coppola, Zvi Vogel

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation

Sandra M. Rocha, Tatiana Saraiva, Ana C. Cristóvão, Raquel Ferreira, Tiago Santos, Marta Esteves, Cláudia Saraiva, Goun Je, Luísa Cortes, Jorge Valero, Gilberto Alves, Alexander Klibanov, Yoon-Seong Kim, Liliana Bernardino

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

Saskia Maria Burm, Laura Anna Norma Peferoen, Ella Alwine Zuiderwijk-Sick, Krista Geraldine Haanstra, Bert Adriaan ‘t Hart, Paul van der Valk, Sandra Amor, Jan Bauer, Jeffrey John Bajramovic

01.12.2016 | Research | Ausgabe 1/2016 Open Access

IL4 induces IL6-producing M2 macrophages associated to inhibition of neuroinflammation in vitro and in vivo

Giacomo Casella, Livia Garzetti, Alberto T. Gatta, Annamaria Finardi, Chiara Maiorino, Francesca Ruffini, Gianvito Martino, Luca Muzio, Roberto Furlan

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Combined [18F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in mice

Ina Israel, Andrea Ohsiek, Ehab Al-Momani, Christiane Albert-Weissenberger, Christian Stetter, Stine Mencl, Andreas K. Buck, Christoph Kleinschnitz, Samuel Samnick, Anna-Leena Sirén

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Interleukin-6: an emerging regulator of pathological pain

Ya-Qun Zhou, Zheng Liu, Zhi-Heng Liu, Shu-Ping Chen, Man Li, Allahverdi Shahveranov, Da-Wei Ye, Yu-Ke Tian

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Altered excitatory-inhibitory balance within somatosensory cortex is associated with enhanced plasticity and pain sensitivity in a mouse model of multiple sclerosis

Liam E. Potter, John W. Paylor, Jee Su Suh, Gustavo Tenorio, Jayalakshmi Caliaperumal, Fred Colbourne, Glen Baker, Ian Winship, Bradley J. Kerr

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Fingolimod promotes peripheral nerve regeneration via modulation of lysophospholipid signaling

Fabian Szepanowski, Angelika Derksen, Irina Steiner, Gerd Meyer zu Hörste, Thomas Daldrup, Hans-Peter Hartung, Bernd C. Kieseier

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

Shamsudheen Moidunny, Marco Matos, Evelyn Wesseling, Santanu Banerjee, David J. Volsky, Rodrigo A. Cunha, Paula Agostinho, Hendrikus W. Boddeke, Sabita Roy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

Yun Qian, Jun Yin, Juan Hong, Guoxi Li, Baofeng Zhang, George Liu, Qi Wan, Ling Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration

Carolina Pellegrini, Matteo Fornai, Rocchina Colucci, Erika Tirotta, Fabio Blandini, Giovanna Levandis, Silvia Cerri, Cristina Segnani, Chiara Ippolito, Nunzia Bernardini, Karolina Cseri, Corrado Blandizzi, György Haskó, Luca Antonioli

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Anti-inflammatory effect of cholera toxin B subunit in experimental stroke

Lei Zhang, Yanxia Huang, Yinyao Lin, Yilong Shan, Sha Tan, Wei Cai, Haiyan Li, Bingjun Zhang, Xuejiao Men, Zhengqi Lu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway

Harsharan S. Bhatia, Julian Baron, Stephanie Hagl, Gunter P. Eckert, Bernd L. Fiebich

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism

Alessia De Felice, Anita Greco, Gemma Calamandrei, Luisa Minghetti

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury

Valeria Sasso, Elisa Bisicchia, Laura Latini, Veronica Ghiglieri, Fabrizio Cacace, Valeria Carola, Marco Molinari, Maria Teresa Viscomi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation?

Frederick Bonsack IV, Cargill H. Alleyne Jr, Sangeetha Sukumari-Ramesh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Phenotypic clustering: a novel method for microglial morphology analysis

Franck Verdonk, Pascal Roux, Patricia Flamant, Laurence Fiette, Fernando A. Bozza, Sébastien Simard, Marc Lemaire, Benoit Plaud, Spencer L. Shorte, Tarek Sharshar, Fabrice Chrétien, Anne Danckaert

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial

David J. Allison, Aysha Thomas, Kayleigh Beaudry, David S. Ditor

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The immunomodulator decoy receptor 3 improves locomotor functional recovery after spinal cord injury

Chuan-Wen Chiu, Wen-Hung Huang, Shao-Ji Lin, May-Jywan Tsai, Hsu Ma, Shie-Liang Hsieh, Henrich Cheng

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Immune response in the eye following epileptic seizures

Matilda Ahl, Una Avdic, Cecilia Skoug, Idrish Ali, Deepti Chugh, Ulrica Englund Johansson, Christine T Ekdahl

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Combining systemic and stereotactic MEMRI to detect the correlation between gliosis and neuronal connective pathway at the chronic stage after stroke

Xiao-zhu Hao, Le-kang Yin, Xiao-xue Zhang, Jia-qi Tian, Chan-chan Li, Xiao-yuan Feng, Min Jiang, Yan-mei Yang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Multivariate projection method to investigate inflammation associated with secondary insults and outcome after human traumatic brain injury: a pilot study

Anna Teresa Mazzeo, Claudia Filippini, Rosalba Rosato, Vito Fanelli, Barbara Assenzio, Ian Piper, Timothy Howells, Ilaria Mastromauro, Maurizio Berardino, Alessandro Ducati, Luciana Mascia

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons

Shijun Wang, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

IL-33 signaling is essential to attenuate viral-induced encephalitis development by downregulating iNOS expression in the central nervous system

Rafael F. O. Franca, Renata S. Costa, Jaqueline R. Silva, Raphael S. Peres, Leila R. Mendonça, David F. Colón, José Carlos Alves-Filho, Fernando Q. Cunha

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Thalamocortical-auditory network alterations following cuprizone‐induced demyelination

Nikoo Ghaffarian, Masoud Mesgari, Manuela Cerina, Kerstin Göbel, Thomas Budde, Erwin-Josef Speckmann, Sven G. Meuth, Ali Gorji

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

Lewis M. Watkins, James W. Neal, Sam Loveless, Iliana Michailidou, Valeria Ramaglia, Mark I. Rees, Richard Reynolds, Neil P. Robertson, B. Paul Morgan, Owain W. Howell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

C-C motif chemokine ligand 20 regulates neuroinflammation following spinal cord injury via Th17 cell recruitment

Jianzhong Hu, Zhiming Yang, Xiaoning Li, Hongbin Lu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain

Jie Yu, Ying-Ying Tang, Ran-Ran Wang, Guo-Dong Lou, Ting-Ting Hu, Wei-Wei Hou, Jia-Xing Yue, Hiroshi Ohtsu, Li-Yun Shi, Shi-Hong Zhang, Zhong Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

New insights into the pharmacokinetics and pharmacodynamics of natalizumab treatment for patients with multiple sclerosis, obtained from clinical and in vitro studies

T. Sehr, U. Proschmann, K. Thomas, M. Marggraf, E. Straube, H. Reichmann, A. Chan, T. Ziemssen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats

Masaaki Korai, Keiko T. Kitazato, Yoshiteru Tada, Takeshi Miyamoto, Kenji Shimada, Nobuhisa Matsushita, Yasuhisa Kanematsu, Junichiro Satomi, Tomoki Hashimoto, Shinji Nagahiro

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Inhibition of myeloperoxidase oxidant production by N-acetyl lysyltyrosylcysteine amide reduces brain damage in a murine model of stroke

Guoliang Yu, Ye Liang, Ziming Huang, Deron W. Jones, Kirkwood A. Pritchard Jr, Hao Zhang

01.12.2016 | Hypothesis | Ausgabe 1/2016 Open Access

MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?

Kévin Baranger, Michel Khrestchatisky, Santiago Rivera

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

Jing-Ya Wang, Ya-Ni Huang, Chong-Chi Chiu, David Tweedie, Weiming Luo, Chaim G. Pick, Szu-Yi Chou, Yu Luo, Barry J. Hoffer, Nigel H. Greig, Jia-Yi Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage

Catalina Abad, Bhavaani Jayaram, Laurine Becquet, Yuqi Wang, M Sue O’Dorisio, James A. Waschek, Yossan-Var Tan

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture

Roanna J. Hall, Leiv Otto Watne, Ane-Victoria Idland, Johan Raeder, Frede Frihagen, Alasdair M. J. MacLullich, Anne Cathrine Staff, Torgeir Bruun Wyller, Durk Fekkes

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Adult obese mice suffer from chronic secondary brain injury after mild TBI

Matthew Sherman, Ming-Mei Liu, Shari Birnbaum, Steven E. Wolf, Joseph P. Minei, Joshua W. Gatson

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Minocycline attenuates interferon-α-induced impairments in rat fear extinction

Qiang Bi, Lijuan Shi, Pingting Yang, Jianing Wang, Ling Qin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interleukin-1β has trophic effects in microglia and its release is mediated by P2X7R pore

Mastura Monif, Christopher A. Reid, Kim L. Powell, Katherine J. Drummond, Terrence J. O’Brien, David A. Williams

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model

Annika Sommer, Tanja Fadler, Eva Dorfmeister, Anna-Carin Hoffmann, Wei Xiang, Beate Winner, Iryna Prots

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer’s disease

Yuqi Huang, Zhe Zhao, Xiaoli Wei, Yong Zheng, Jianqiang Yu, Jianquan Zheng, Liyun Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Characterization of the binding pattern of human aquaporin-4 autoantibodies in patients with neuromyelitis optica spectrum disorders

Friederike Tuller, Hannah Holzer, Kathrin Schanda, Fahmy Aboulenein-Djamshidian, Romana Höftberger, Michael Khalil, Thomas Seifert-Held, Fritz Leutmezer, Thomas Berger, Markus Reindl

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis

Emiliano Trias, Sofía Ibarburu, Romina Barreto-Núñez, Joël Babdor, Thiago T. Maciel, Matthias Guillo, Laurent Gros, Patrice Dubreuil, Pablo Díaz-Amarilla, Patricia Cassina, Laura Martínez-Palma, Ivan C. Moura, Joseph S. Beckman, Olivier Hermine, Luis Barbeito

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Antibodies to the RNA-binding protein hnRNP A1 contribute to neurodegeneration in a model of central nervous system autoimmune inflammatory disease

Joshua N. Douglas, Lidia A. Gardner, Hannah E. Salapa, Stephen J. Lalor, Sangmin Lee, Benjamin M. Segal, Paul E. Sawchenko, Michael C. Levin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Circulating microRNAs as biomarkers for rituximab therapy, in neuromyelitis optica (NMO)

Adi Vaknin-Dembinsky, Hanna Charbit, Livnat Brill, Oded Abramsky, Devorah Gur-Wahnon, Iddo Z. Ben-Dov, Iris Lavon

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models

Xiao-Long Sun, Bei-Yu Chen, Hai-Kang Zhao, Ying-Ying Cheng, Min-Hua Zheng, Li Duan, Wen Jiang, Liang-Wei Chen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Long-term exposure to PGE2 causes homologous desensitization of receptor-mediated activation of protein kinase A

Ramy Habashy Malty, Andy Hudmon, Jill C. Fehrenbacher, Michael R. Vasko

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Transcriptome sequencing reveals that LPS-triggered transcriptional responses in established microglia BV2 cell lines are poorly representative of primary microglia

Amitabh Das, Sun Hwa Kim, Sarder Arifuzzaman, Taeho Yoon, Jin Choul Chai, Young Seek Lee, Kyoung Sun Park, Kyoung Hwa Jung, Young Gyu Chai

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice

Qian Zhang, De-Li Cao, Zhi-Jun Zhang, Bao-Chun Jiang, Yong-Jing Gao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation

Weiguo Dong, Christine M. Embury, Yaman Lu, Sarah M. Whitmire, Bhagyalaxmi Dyavarshetty, Harris A. Gelbard, Howard E. Gendelman, Tomomi Kiyota

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Lymphocytes influence intracranial aneurysm formation and rupture: role of extracellular matrix remodeling and phenotypic modulation of vascular smooth muscle cells

David M. Sawyer, Lauren A. Pace, Crissey L. Pascale, Alexander C. Kutchin, Brannan E. O’Neill, Robert M. Starke, Aaron S. Dumont

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite

Liang Feng, Yizhao Chen, Rui Ding, Zhenghao Fu, Shuo Yang, Xinqing Deng, Jun Zeng

01.12.2016 | Research | Ausgabe 1/2016 Open Access

TLR2 and TLR9 modulate enteric nervous system inflammatory responses to lipopolysaccharide

Joan F. Burgueño, Albert Barba, Elena Eyre, Carolina Romero, Michel Neunlist, Ester Fernández

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model

Kin Ki Jim, JooYeon Engelen-Lee, Astrid M. van der Sar, Wilbert Bitter, Matthijs C. Brouwer, Arie van der Ende, Jan-Willem Veening, Diederik van de Beek, Christina M. J. E. Vandenbroucke-Grauls

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Sinead A. O’Sullivan, Fabrizio Gasparini, Anis K. Mir, Kumlesh K. Dev

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cuprizone demyelination induces a unique inflammatory response in the subventricular zone

James M. Hillis, Julie Davies, Mayara Vieira Mundim, Osama Al-Dalahmah, Francis G. Szele

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression

Savina Apolloni, Paola Fabbrizio, Susanna Amadio, Cinzia Volonté

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Class I PI3K inhibitor ZSTK474 mediates a shift in microglial/macrophage phenotype and inhibits inflammatory response in mice with cerebral ischemia/reperfusion injury

Po Wang, Yating He, Daojing Li, Ranran Han, Guiyou Liu, Dexin Kong, Junwei Hao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study

Muskan Gupta, Gurcharan Kaur

01.12.2016 | Research | Ausgabe 1/2016 Open Access

HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer’s disease

Barry W. Festoff, Ravi K. Sajja, Patrick van Dreden, Luca Cucullo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Decreased haemodynamic response and decoupling of cortical gamma-band activity and tissue oxygen perfusion after striatal interleukin-1 injection

Natasha Bray, Fiona E. Burrows, Myles Jones, Jason Berwick, Stuart M. Allan, Ingo Schiessl

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Type-1 angiotensin receptor signaling in central nervous system myeloid cells is pathogenic during fatal alphavirus encephalitis in mice

Pennelope K. Blakely, Amanda K. Huber, David N. Irani

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury

Tingting Dong, Liang Zhi, Brijesh Bhayana, Mei X. Wu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Fractalkine suppression during hepatic encephalopathy promotes neuroinflammation in mice

Matthew McMillin, Stephanie Grant, Gabriel Frampton, Sarah Andry, Adam Brown, Sharon DeMorrow

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke

Zhiliang Guo, Shuhong Yu, Lulu Xiao, Xin Chen, Ruidong Ye, Ping Zheng, Qiliang Dai, Wen Sun, Changsheng Zhou, Shuiping Wang, Wusheng Zhu, Xinfeng Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Red LED photobiomodulation reduces pain hypersensitivity and improves sensorimotor function following mild T10 hemicontusion spinal cord injury

Di Hu, Shuyu Zhu, Jason Robert Potas

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

α-Synuclein deficiency promotes neuroinflammation by increasing Th1 cell-mediated immune responses

Benjamin Ettle, Kristina Kuhbandner, Stefanie Jörg, Alana Hoffmann, Jürgen Winkler, Ralf A. Linker

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dysregulation of the (immuno)proteasome pathway in malformations of cortical development

J. van Scheppingen, D. W. M. Broekaart, T. Scholl, M. R. J. Zuidberg, J. J. Anink, W. G. Spliet, P. C. van Rijen, T. Czech, J. A. Hainfellner, M. Feucht, A. Mühlebner, E. A. van Vliet, E. Aronica

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Etifoxine improves sensorimotor deficits and reduces glial activation, neuronal degeneration, and neuroinflammation in a rat model of traumatic brain injury

Emmanuelle Simon-O’Brien, Delphine Gauthier, Véronique Riban, Marc Verleye

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The glucagon-like peptide-1 receptor agonist exendin-4 ameliorates warfarin-associated hemorrhagic transformation after cerebral ischemia

Fangzhe Chen, Weifeng Wang, Hongyan Ding, Qi Yang, Qiang Dong, Mei Cui

01.12.2016 | Research | Ausgabe 1/2016 Open Access

1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype

Ioanna Plastira, Eva Bernhart, Madeleine Goeritzer, Helga Reicher, Vishwanath Bhat Kumble, Nora Kogelnik, Andrea Wintersperger, Astrid Hammer, Stefanie Schlager, Katharina Jandl, Akos Heinemann, Dagmar Kratky, Ernst Malle, Wolfgang Sattler

01.12.2016 | Research | Ausgabe 1/2016 Open Access

High-fat diet feeding differentially affects the development of inflammation in the central nervous system

Owein Guillemot-Legris, Julien Masquelier, Amandine Everard, Patrice D. Cani, Mireille Alhouayek, Giulio G. Muccioli

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis

Antonietta Gentile, Alessandra Musella, Silvia Bullitta, Diego Fresegna, Francesca De Vito, Roberta Fantozzi, Eleonora Piras, Francesca Gargano, Giovanna Borsellino, Luca Battistini, Anna Schubart, Georgia Mandolesi, Diego Centonze

01.12.2016 | Research | Ausgabe 1/2016 Open Access

miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions

Susu Mao, Xiuhua Li, Jin Wang, Xin Ding, Chenyu Zhang, Liang Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Tick-borne encephalitis virus induces chemokine RANTES expression via activation of IRF-3 pathway

Xiaowei Zhang, Zhenhua Zheng, Xijuan Liu, Bo Shu, Panyong Mao, Bingke Bai, Qinxue Hu, Minhua Luo, Xiaohe Ma, Zongqiang Cui, Hanzhong Wang

01.12.2016 | Short Report | Ausgabe 1/2016 Open Access

Secreted herpes simplex virus-2 glycoprotein G alters thermal pain sensitivity by modifying NGF effects on TRPV1

Jorge Rubén Cabrera, Abel Viejo-Borbolla, Antonio Alcamí, Francisco Wandosell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

Jan Hirsch, Susana Vacas, Niccolo Terrando, Miao Yuan, Laura P. Sands, Joel Kramer, Kevin Bozic, Mervyn M. Maze, Jacqueline M. Leung

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients

Pooja-Shree Mishra, Dinesh K. Dhull, A. Nalini, K. Vijayalakshmi, T. N. Sathyaprabha, Phalguni Anand Alladi, Trichur R. Raju

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1

Franca Orsini, Elvina Chrysanthou, Thomas Dudler, W. Jason Cummings, Minoru Takahashi, Teizo Fujita, Gregory Demopulos, Maria-Grazia De Simoni, Wilhelm Schwaeble

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Bullatine A stimulates spinal microglial dynorphin A expression to produce anti-hypersensitivity in a variety of rat pain models

Qian Huang, Xiao-Fang Mao, Hai-Yun Wu, Teng-Fei Li, Ming-Li Sun, Hao Liu, Yong-Xiang Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Colony-stimulating factor 1 receptor blockade prevents fractionated whole-brain irradiation-induced memory deficits

Xi Feng, Timothy D. Jopson, Maria Serena Paladini, Sharon Liu, Brian L. West, Nalin Gupta, Susanna Rosi

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: IFN-gamma signaling in the central nervous system controls the course of experimental autoimmune encephalomyelitis independently of the localization and composition of inflammatory foci

Eunyoung Lee, Sarah Chamanara, David Pleasure, Athena M. Soulika

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Interleukin-6, MCP-1, IP-10, and MIG are sequentially expressed in cerebrospinal fluid after subarachnoid hemorrhage

Aichi Niwa, Koji Osuka, Takahiro Nakura, Naoki Matsuo, Takeya Watabe, Masakazu Takayasu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A murine model of inflammation-induced cerebral microbleeds

Rachita K. Sumbria, Mher Mahoney Grigoryan, Vitaly Vasilevko, Tatiana B. Krasieva, Miriam Scadeng, Alexandra K. Dvornikova, Annlia Paganini-Hill, Ronald Kim, David H. Cribbs, Mark J. Fisher

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system

Nese Sinmaz, Tina Nguyen, Fiona Tea, Russell C. Dale, Fabienne Brilot

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Exacerbation of blast-induced ocular trauma by an immune response

Courtney Bricker-Anthony, Jessica Hines-Beard, Lauren D’Surney, Tonia S. Rex

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Assessment of neuroinflammation in a mouse model of obesity and β-amyloidosis using PET

Anna M. Barron, Masaki Tokunaga, Ming-Rong Zhang, Bin Ji, Tetsuya Suhara, Makoto Higuchi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Modulatory effects of perforin gene dosage on pathogen-associated blood-brain barrier (BBB) disruption

Robin C. Willenbring, Fang Jin, David J. Hinton, Mike Hansen, Doo-Sup Choi, Kevin D. Pavelko, Aaron J. Johnson

20.07.2016 | Research | Ausgabe 1/2016 Open Access

CCR5 ameliorates Japanese encephalitis via dictating the equilibrium of regulatory CD4+Foxp3+ T and IL-17+CD4+ Th17 cells

Jin Hyoung Kim, Ajit Mahadev Patil, Jin Young Choi, Seong Bum Kim, Erdenebelig Uyangaa, Ferdaus Mohd Altaf Hossain, Sang-Youel Park, John Hwa Lee, Seong Kug Eo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Social defeat induces depressive-like states and microglial activation without involvement of peripheral macrophages

Michael L. Lehmann, Hannah A. Cooper, Dragan Maric, Miles Herkenham

01.12.2016 | Research | Ausgabe 1/2016 Open Access

SPARC expression by cerebral microvascular endothelial cells in vitro and its influence on blood-brain barrier properties

Samir Alkabie, Jayasree Basivireddy, Lixin Zhou, Jane Roskams, Peter Rieckmann, Jacqueline A. Quandt

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cellular investigations with human antibodies associated with the anti-IgLON5 syndrome

Lidia Sabater, Jesús Planagumà, Josep Dalmau, Francesc Graus

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of α5β1 and αVβ3 integrins

Heng Huang, Qijuan Huang, Fuxin Wang, Richard Milner, Longxuan Li

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat

Jing-Ya Wang, Ya-Ni Huang, Chong-Chi Chiu, David Tweedie, Weiming Luo, Chaim G. Pick, Szu-Yi Chou, Yu Luo, Barry J. Hoffer, Nigel H. Greig, Jia-Yi Wang

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats

Antwoine Flowers, Jea-Young Lee, Bethany Grimmig, Sandra Acosta, Charles Hudson, Brent Small, Cyndy D. Sanberg, Paula C. Bickford

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Electroconvulsive shock attenuated microgliosis and astrogliosis in the hippocampus and ameliorated schizophrenia-like behavior of Gunn rat

Erlyn Limoa, Sadayuki Hashioka, Tsuyoshi Miyaoka, Keiko Tsuchie, Ryosuke Arauchi, Ilhamuddin A. Azis, Rei Wake, Maiko Hayashida, Tomoko Araki, Motohide Furuya, Kristian Liaury, Andi J. Tanra, Jun Horiguchi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis

Antonietta Gentile, Diego Fresegna, Alessandra Musella, Helena Sepman, Silvia Bullitta, Francesca De Vito, Roberta Fantozzi, Alessandro Usiello, Mauro Maccarrone, Nicola B. Mercuri, Beat Lutz, Georgia Mandolesi, Diego Centonze

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Metabolic determinants of the immune modulatory function of neural stem cells

Denise Drago, Veronica Basso, Edoardo Gaude, Giulio Volpe, Luca Peruzzotti-Jametti, Angela Bachi, Giovanna Musco, Annapaola Andolfo, Christian Frezza, Anna Mondino, Stefano Pluchino

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models

Pongsatorn Meesawatsom, James Burston, Gareth Hathway, Andrew Bennett, Victoria Chapman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide

Miriam Ries, Rodrigo Loiola, Urvi N. Shah, Steve M. Gentleman, Egle Solito, Magdalena Sastre

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The crucial role of Erk2 in demyelinating inflammation in the central nervous system

Rentaro Okazaki, Toru Doi, Kentaro Hayakawa, Kazuhito Morioka, Osamu Imamura, Kunio Takishima, Makoto Hamanoue, Yasuhiro Sawada, Motoshi Nagao, Sakae Tanaka, Toru Ogata

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

Ian A. Clark, Bryce Vissel

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway

Lauren J. Simmons, Monique C. Surles-Zeigler, Yonggang Li, Gregory D. Ford, Gale D. Newman, Byron D. Ford

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Intra-amniotic LPS causes acute neuroinflammation in preterm rhesus macaques

Augusto F. Schmidt, Paranthaman S. Kannan, Claire A. Chougnet, Steve C. Danzer, Lisa A. Miller, Alan H. Jobe, Suhas G. Kallapur

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study

Yuri Nakamura, Takuya Matsushita, Shinya Sato, Masaaki Niino, Toshiyuki Fukazawa, Satoshi Yoshimura, Shin Hisahara, Noriko Isobe, Shun Shimohama, Mitsuru Watanabe, Kazuto Yoshida, Hideki Houzen, Yusei Miyazaki, Ryo Yamasaki, Seiji Kikuchi, Jun-ichi Kira, the Japan Multiple Sclerosis Genetics Consortium

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease

Laura L. Dickey, Colleen L. Worne, Jessica L. Glover, Thomas E. Lane, Ryan M. O’Connell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Glycyrrhizin protects against focal cerebral ischemia via inhibition of T cell activity and HMGB1-mediated mechanisms

Xiaoxing Xiong, Lijuan Gu, Yan Wang, Ying Luo, Hongfei Zhang, Jessica Lee, Sheri Krams, Shengmei Zhu, Heng Zhao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes

Victoria Lutgen, Srinivas D. Narasipura, Amit Sharma, Stephanie Min, Lena Al-Harthi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Antibody profiling identifies novel antigenic targets in spinal cord injury patients

Ilse Palmers, Elke Ydens, Eric Put, Bart Depreitere, Helma Bongers-Janssen, Peter Pickkers, Sven Hendrix, Veerle Somers

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Heme oxygenase-1-mediated neuroprotection in subarachnoid hemorrhage via intracerebroventricular deferoxamine

Robert H. LeBlanc III, Ruiya Chen, Magdy H. Selim, Khalid A. Hanafy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy

Sherry Dadsetan, Tiziano Balzano, Jerónimo Forteza, Ana Agusti, Andrea Cabrera-Pastor, Lucas Taoro-Gonzalez, Vicente Hernandez-Rabaza, Belen Gomez-Gimenez, Nisrin ElMlili, Marta Llansola, Vicente Felipo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Oxidative damage and chemokine production dominate days before immune cell infiltration and EAE disease debut

Henrik Hasseldam, Rune Skovgaard Rasmussen, Flemming Fryd Johansen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression

Pejman Rahimian, Johnny J. He

01.12.2016 | Research | Ausgabe 1/2016 Open Access

miR-124a and miR-155 enhance differentiation of regulatory T cells in patients with neuropathic pain

Jens Heyn, Benjamin Luchting, Ludwig C. Hinske, Max Hübner, Shahnaz C. Azad, Simone Kreth

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes

Deidre Jansson, Emma L. Scotter, Justin Rustenhoven, Natacha Coppieters, Leon C. D. Smyth, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, E. Scott Graham, Richard L. M. Faull, Mike Dragunow

01.12.2016 | Research | Ausgabe 1/2016 Open Access

In vitro evaluation of physiologically relevant concentrations of teriflunomide on activation and proliferation of primary rodent microglia

Tanja Wostradowski, Chittappen Kandiyil Prajeeth, Viktoria Gudi, Jessica Kronenberg, Sina Witte, Marina Brieskorn, Martin Stangel

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Andrographolide induces Nrf2 and heme oxygenase 1 in astrocytes by activating p38 MAPK and ERK

Siew Ying Wong, Michelle G. K. Tan, Peter T. H. Wong, Deron R. Herr, Mitchell K. P. Lai

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and l-type Ca2+ channels upstream of p38 MAPK

Ana B. Sanchez, Kathryn E. Medders, Ricky Maung, Paloma Sánchez-Pavón, Daniel Ojeda-Juárez, Marcus Kaul

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Reduced acute neuroinflammation and improved functional recovery after traumatic brain injury by α-linolenic acid supplementation in mice

Abhishek Desai, Taeyeop Park, Jaquel Barnes, Karl Kevala, Huazhen Chen, Hee-Yong Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier

Slava Rom, Viviana Zuluaga-Ramirez, Nancy L. Reichenbach, Holly Dykstra, Sachin Gajghate, Pal Pacher, Yuri Persidsky

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Loss of Schwann cell plasticity in chronic inflammatory demyelinating polyneuropathy (CIDP)

Abhijeet R. Joshi, Laura Holtmann, Ilja Bobylev, Christian Schneider, Christian Ritter, Joachim Weis, Helmar C. Lehmann

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Immunomodulatory effects of nicotine on interleukin 1β activated human astrocytes and the role of cyclooxygenase 2 in the underlying mechanism

Priya Revathikumar, Filip Bergqvist, Srividya Gopalakrishnan, Marina Korotkova, Per-Johan Jakobsson, Jon Lampa, Erwan Le Maître

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Brain omega-3 polyunsaturated fatty acids modulate microglia cell number and morphology in response to intracerebroventricular amyloid-β 1-40 in mice

Kathryn E. Hopperton, Marc-Olivier Trépanier, Vanessa Giuliano, Richard P. Bazinet

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Upregulation of neuronal zinc finger protein A20 expression is required for electroacupuncture to attenuate the cerebral inflammatory injury mediated by the nuclear factor-kB signaling pathway in cerebral ischemia/reperfusion rats

Jian Zhan, Wenyi Qin, Ying Zhang, Jing Jiang, Hongmei Ma, Qiongli Li, Yong Luo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes

Qiuying Zhao, Xiaohui Wu, Shuo Yan, Xiaofang Xie, Yonghua Fan, Jinqiang Zhang, Cheng Peng, Zili You

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship

Xin Sun, Zachary B. Jones, Xiao-ming Chen, Libing Zhou, Kwok-Fai So, Yi Ren

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Immune response in peripheral axons delays disease progression in SOD1G93A mice

Giovanni Nardo, Maria Chiara Trolese, Giuseppe de Vito, Roberta Cecchi, Nilo Riva, Giorgia Dina, Paul R. Heath, Angelo Quattrini, Pamela J. Shaw, Vincenzo Piazza, Caterina Bendotti

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

Maria Pannell, Dominika Labuz, Melih Ö. Celik, Jacqueline Keye, Arvind Batra, Britta Siegmund, Halina Machelska

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice

Jing Qiu, Zhongjun Yan, Kai Tao, Yansong Li, Yuqian Li, Jingchen Li, Yushu Dong, Dayun Feng, Huisheng Chen

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation

Frances Corrigan, Kimberley A. Mander, Anna V. Leonard, Robert Vink

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Nogo receptor complex expression dynamics in the inflammatory foci of central nervous system experimental autoimmune demyelination

Paschalis Theotokis, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Evangelia Kesidou, Spyridon Siafis, Theodoros Tselios, Athanasios Lourbopoulos, Dimitrios Karacostas, Nikolaos Grigoriadis, Constantina Simeonidou

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Activation of the hypothalamic-pituitary-adrenal (HPA) axis contributes to the immunosuppression of mice infected with Angiostrongylus cantonensis

Ai-ling Chen, Xi Sun, Wei Wang, Jin-feng Liu, Xin Zeng, Jing-fan Qiu, Xin-jian Liu, Yong Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication

Brenna M. Flannery, Donald A. Bruun, Douglas J. Rowland, Christopher N. Banks, Adam T. Austin, David L. Kukis, Yonggang Li, Byron D. Ford, Daniel J. Tancredi, Jill L. Silverman, Simon R. Cherry, Pamela J. Lein

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction

Yuping Li, Ke Pan, Lin Chen, Jiao-lin Ning, Xiaojun Li, Ting Yang, Niccolò Terrando, Jianteng Gu, Guocai Tao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Fumarate modulates the immune/inflammatory response and rescues nerve cells and neurological function after stroke in rats

Ruihe Lin, Jingli Cai, Eric W. Kostuk, Robert Rosenwasser, Lorraine Iacovitti

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy

Kenneth I. Strauss, Kost V. Elisevich

01.12.2016 | Research | Ausgabe 1/2016 Open Access

IL-10 plays an important role in the control of inflammation but not in the bacterial burden in S. epidermidis CNS catheter infection

Yenis M. Gutierrez-Murgas, Gwenn Skar, Danielle Ramirez, Matthew Beaver, Jessica N. Snowden

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Loss of cerebellar neurons in the progression of lentiviral disease: effects of CNS-permeant antiretroviral therapy

Christian Wächter, Lee E. Eiden, Nedye Naumann, Candan Depboylu, Eberhard Weihe

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cerebrospinal fluid cytokines in Lyme neuroborreliosis

Annukka Pietikäinen, Mikael Maksimow, Tommi Kauko, Saija Hurme, Marko Salmi, Jukka Hytönen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis

Xiao-Pei Yang, Ji-Yang Fu, Rui-Cheng Yang, Wen-Tong Liu, Tao Zhang, Bo Yang, Ling Miao, Bei-Bei Dou, Chen Tan, Huan-Chun Chen, Xiang-Ru Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement-independent retinal pathology produced by intravitreal injection of neuromyelitis optica immunoglobulin G

Christian M. Felix, Marc H. Levin, Alan S. Verkman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ

Elena Hernandez-Encinas, Diana Aguilar-Morante, Jose A. Morales-Garcia, Elena Gine, Marina Sanz-SanCristobal, Angel Santos, Ana Perez-Castillo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

Richard Lindqvist, Filip Mundt, Jonathan D. Gilthorpe, Silke Wölfel, Nelson O. Gekara, Andrea Kröger, Anna K. Överby

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy

Sven Jarius, Marius Ringelstein, Jürgen Haas, Irina I. Serysheva, Lars Komorowski, Kai Fechner, Klaus-Peter Wandinger, Philipp Albrecht, Harald Hefter, Andreas Moser, Eva Neuen-Jacob, Hans-Peter Hartung, Brigitte Wildemann, Orhan Aktas

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin

Sven Jarius, Klemens Ruprecht, Ingo Kleiter, Nadja Borisow, Nasrin Asgari, Kalliopi Pitarokoili, Florence Pache, Oliver Stich, Lena-Alexandra Beume, Martin W. Hümmert, Corinna Trebst, Marius Ringelstein, Orhan Aktas, Alexander Winkelmann, Mathias Buttmann, Alexander Schwarz, Hanna Zimmermann, Alexander U. Brandt, Diego Franciotta, Marco Capobianco, Joseph Kuchling, Jürgen Haas, Mirjam Korporal-Kuhnke, Soeren Thue Lillevang, Kai Fechner, Kathrin Schanda, Friedemann Paul, Brigitte Wildemann, Markus Reindl, in cooperation with the Neuromyelitis Optica Study Group (NEMOS)

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome

Sven Jarius, Klemens Ruprecht, Ingo Kleiter, Nadja Borisow, Nasrin Asgari, Kalliopi Pitarokoili, Florence Pache, Oliver Stich, Lena-Alexandra Beume, Martin W. Hümmert, Marius Ringelstein, Corinna Trebst, Alexander Winkelmann, Alexander Schwarz, Mathias Buttmann, Hanna Zimmermann, Joseph Kuchling, Diego Franciotta, Marco Capobianco, Eberhard Siebert, Carsten Lukas, Mirjam Korporal-Kuhnke, Jürgen Haas, Kai Fechner, Alexander U. Brandt, Kathrin Schanda, Orhan Aktas, Friedemann Paul, Markus Reindl, Brigitte Wildemann, in cooperation with the Neuromyelitis Optica Study Group (NEMOS)

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 3: Brainstem involvement - frequency, presentation and outcome

Sven Jarius, Ingo Kleiter, Klemens Ruprecht, Nasrin Asgari, Kalliopi Pitarokoili, Nadja Borisow, Martin W. Hümmert, Corinna Trebst, Florence Pache, Alexander Winkelmann, Lena-Alexandra Beume, Marius Ringelstein, Oliver Stich, Orhan Aktas, Mirjam Korporal-Kuhnke, Alexander Schwarz, Carsten Lukas, Jürgen Haas, Kai Fechner, Mathias Buttmann, Judith Bellmann-Strobl, Hanna Zimmermann, Alexander U. Brandt, Diego Franciotta, Kathrin Schanda, Friedemann Paul, Markus Reindl, Brigitte Wildemann, in cooperation with the Neuromyelitis Optica Study Group (NEMOS)

01.12.2016 | Research | Ausgabe 1/2016 Open Access

MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 4: Afferent visual system damage after optic neuritis in MOG-IgG-seropositive versus AQP4-IgG-seropositive patients

Florence Pache, Hanna Zimmermann, Janine Mikolajczak, Sophie Schumacher, Anna Lacheta, Frederike C. Oertel, Judith Bellmann-Strobl, Sven Jarius, Brigitte Wildemann, Markus Reindl, Amy Waldman, Kerstin Soelberg, Nasrin Asgari, Marius Ringelstein, Orhan Aktas, Nikolai Gross, Mathias Buttmann, Thomas Ach, Klemens Ruprecht, Friedemann Paul, Alexander U. Brandt, in cooperation with the Neuromyelitis Optica Study Group (NEMOS)

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus

Anna A. Tyrtyshnaia, Larisa V. Lysenko, Francisco Madamba, Igor V. Manzhulo, Maxim Y. Khotimchenko, Alexander M. Kleschevnikov

01.12.2016 | Research | Ausgabe 1/2016 Open Access

N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling

Taeyeop Park, Huazhen Chen, Karl Kevala, Ji-Won Lee, Hee-Yong Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Spatio-temporal profile, phenotypic diversity, and fate of recruited monocytes into the post-ischemic brain

Lidia Garcia-Bonilla, Giuseppe Faraco, Jamie Moore, Michelle Murphy, Gianfranco Racchumi, Jayashree Srinivasan, David Brea, Costantino Iadecola, Josef Anrather

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Anthocyanins abrogate glutamate-induced AMPK activation, oxidative stress, neuroinflammation, and neurodegeneration in postnatal rat brain

Shahid Ali Shah, Faiz Ul Amin, Mehtab Khan, Muhammad Noman Abid, Shafiq Ur Rehman, Tae Hyun Kim, Min Woo Kim, Myeong Ok Kim

01.12.2016 | Research | Ausgabe 1/2016 Open Access

In vivo inhibition of miR-155 significantly alters post-stroke inflammatory response

Juan Carlos Pena-Philippides, Ernesto Caballero-Garrido, Tamar Lordkipanidze, Tamara Roitbak

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Debbie Le Blon, Caroline Guglielmetti, Chloé Hoornaert, Alessandra Quarta, Jasmijn Daans, Dearbhaile Dooley, Evi Lemmens, Jelle Praet, Nathalie De Vocht, Kristien Reekmans, Eva Santermans, Niel Hens, Herman Goossens, Marleen Verhoye, Annemie Van der Linden, Zwi Berneman, Sven Hendrix, Peter Ponsaerts

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sex-specific variation in signaling pathways and gene expression patterns in human leukocytes in response to endotoxin and exercise

Asghar Abbasi, Rodolfo de Paula Vieira, Felix Bischof, Michael Walter, Masoud Movassaghi, Nicole C. Berchtold, Andreas M. Niess, Carl W. Cotman, Hinnak Northoff

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal cord-derived microvascular endothelial cells

Yves Molino, Françoise Jabès, Amandine Bonnet, Nicolas Gaudin, Anne Bernard, Philippe Benech, Michel Khrestchatisky

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cytokine and chemokine alterations in tissue, CSF, and plasma in early presymptomatic phase of experimental allergic encephalomyelitis (EAE), in a rat model of multiple sclerosis

Nozha Borjini, Mercedes Fernández, Luciana Giardino, Laura Calzà

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles

Debayon Paul, Valentina Baena, Shujun Ge, Xi Jiang, Evan R. Jellison, Timothy Kiprono, Dritan Agalliu, Joel S. Pachter

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Human class I major histocompatibility complex alleles determine central nervous system injury versus repair

Bharath Wootla, Aleksandar Denic, Jens O. Watzlawik, Arthur E. Warrington, Laurie J. Zoecklein, Louisa M. Papke-Norton, Chella David, Moses Rodriguez

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

Yinbing Pan, Xiaodi Sun, Lai Jiang, Liang Hu, Hong Kong, Yuan Han, Cheng Qian, Chao Song, Yanning Qian, Wentao Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons

Rakel López de Maturana, Valérie Lang, Amaia Zubiarrain, Amaya Sousa, Nerea Vázquez, Ana Gorostidi, Julio Águila, Adolfo López de Munain, Manuel Rodríguez, Rosario Sánchez-Pernaute

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells

Gen-Lin He, Zhen Luo, Ting-Ting Shen, Ping Li, Ju Yang, Xue Luo, Chun-Hai Chen, Peng Gao, Xue-Sen Yang

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Balancing the immune response in the brain: IL-10 and its regulation

Diogo Lobo-Silva, Guilhermina M. Carriche, A. Gil Castro, Susana Roque, Margarida Saraiva

01.12.2016 | Short report | Ausgabe 1/2016 Open Access

Brain inflammation is accompanied by peripheral inflammation in Cstb −/− mice, a model for progressive myoclonus epilepsy

Olesya Okuneva, Zhilin Li, Inken Körber, Saara Tegelberg, Tarja Joensuu, Li Tian, Anna-Elina Lehesjoki

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cell cycle inhibition reduces inflammatory responses, neuronal loss, and cognitive deficits induced by hypobaria exposure following traumatic brain injury

Jacob W. Skovira, Junfang Wu, Jessica J. Matyas, Alok Kumar, Marie Hanscom, Shruti V. Kabadi, Raymond Fang, Alan I. Faden

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The histone deacetylase inhibitor, sodium butyrate, exhibits neuroprotective effects for ischemic stroke in middle-aged female rats

Min Jung Park, Farida Sohrabji

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Variable sensitivity to complement-dependent cytotoxicity in murine models of neuromyelitis optica

Yiting Liu, Danielle E. Harlow, Katherine S. Given, Gregory P. Owens, Wendy B. Macklin, Jeffrey L. Bennett

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα

Patrick K Nuro-Gyina, Elizabeth L Rieser, Marissa C Granitto, Wei Pei, Yue Liu, Priscilla W Lee, Saba Aqel, Jian Zhang, Amy E Lovett-Racke, Michael K Racke, Yuhong Yang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Tollip, an early regulator of the acute inflammatory response in the substantia nigra

Marie Humbert-Claude, D. Duc, D. Dwir, L. Thieren, J. Sandström von Tobel, C. Begka, F. Legueux, D. Velin, M. H. Maillard, K. Q. Do, F. Monnet-Tschudi, L. Tenenbaum

01.12.2016 | Research | Ausgabe 1/2016 Open Access

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

Longyu Yang, Chia-Chen Liu, Honghua Zheng, Takahisa Kanekiyo, Yuka Atagi, Lin Jia, Daxin Wang, Aurelie N’songo, Dan Can, Huaxi Xu, Xiao-Fen Chen, Guojun Bu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

miR-15a/16 reduces retinal leukostasis through decreased pro-inflammatory signaling

Eun-Ah Ye, Li Liu, Youde Jiang, Jenny Jan, Subhash Gaddipati, Susmit Suvas, Jena J. Steinle

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

Jacquelyn A. Brown, Simona G. Codreanu, Mingjian Shi, Stacy D. Sherrod, Dmitry A. Markov, M. Diana Neely, Clayton M. Britt, Orlando S. Hoilett, Ronald S. Reiserer, Philip C. Samson, Lisa J. McCawley, Donna J. Webb, Aaron B. Bowman, John A. McLean, John P. Wikswo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pro-epileptogenic effects of viral-like inflammation in both mature and immature brains

Nina Dupuis, Andrey Mazarati, Béatrice Desnous, Vibol Chhor, Bobbi Fleiss, Tifenn Le Charpentier, Sophie Lebon, Zsolt Csaba, Pierre Gressens, Pascal Dournaud, Stéphane Auvin

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