Ausgabe 1/2019
Inhalt (283 Artikel)
Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation
Huadong Ni, Yungong Wang, Kang An, Qianying Liu, Longsheng Xu, Chunyan Zhu, Housheng Deng, Qiuli He, Tingting Wang, Miao Xu, Ying Zheng, Bing Huang, Jianqiao Fang, Ming Yao
Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury
S. T. Peruzzaro, M. M. M. Andrews, A. Al-Gharaibeh, O. Pupiec, M. Resk, D. Story, P. Maiti, J. Rossignol, G. L. Dunbar
Peripheral adaptive immunity of the triple transgenic mouse model of Alzheimer’s disease
Isabelle St-Amour, Cristina R. Bosoi, Isabelle Paré, Prenitha Mercy Ignatius Arokia Doss, Manu Rangachari, Sébastien S. Hébert, Renée Bazin, Frédéric Calon
Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging
Sha Qiao, Yuan Qian, Guoqiang Xu, Qingming Luo, Zhihong Zhang
Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain
Julie A. Wixey, Kah Meng Lee, Stephanie M. Miller, Kate Goasdoue, Paul B. Colditz, S. Tracey Bjorkman, Kirat K. Chand
Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes
Wai Ping Yew, Natalia D. Djukic, Jaya S. P. Jayaseelan, Frederick R. Walker, Karl A. A. Roos, Timothy K. Chataway, Hakan Muyderman, Neil R. Sims
CSF inflammatory markers differ in gram-positive versus gram-negative shunt infections
Gwenn L. Skar, David Synhorst, Matthew Beaver, Jessica N. Snowden
Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch
Wenchao Liu, Ran Li, Jian Yin, Shenquan Guo, Yunchang Chen, Haiyan Fan, Gancheng Li, Zhenjun Li, Xifeng Li, Xin Zhang, Xuying He, Chuanzhi Duan
The phagocytic state of brain myeloid cells after ischemia revealed by superresolution structured illumination microscopy
Stefano Fumagalli, Fabio Fiordaliso, Carlo Perego, Alessandro Corbelli, Alessandro Mariani, Massimiliano De Paola, Maria-Grazia De Simoni
Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway
Qing Liu, Yanli Zhang, Shuang Liu, Yanna Liu, Xiaohan Yang, Gang Liu, Takahiro Shimizu, Kazuhiro Ikenaka, Kai Fan, Jianmei Ma
Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury
Victoria L. DiBona, Wenxin Zhu, Mihir K. Shah, Aditi Rafalia, Hajer Ben Cheikh, David P. Crockett, Huaye Zhang
Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition
Kristyna Karova, John V. Wainwright, Lucia Machova-Urdzikova, Rishikaysh V. Pisal, Meic Schmidt, Pavla Jendelova, Meena Jhanwar-Uniyal
Cerebrospinal fluid CXLC13 indicates disease course in neuroinfection: an observational study
Georg Pilz, Peter Wipfler, Ferdinand Otto, Wolfgang Hitzl, Shahrzad Afazel, Elisabeth Haschke-Becher, Eugen Trinka, Andrea Harrer
A novel neurotherapeutic for multiple sclerosis, ischemic injury, methamphetamine addiction, and traumatic brain injury
Arthur A. Vandenbark, Roberto Meza-Romero, Gil Benedek, Halina Offner
Blood-brain barrier permeability and physical exercise
Marta A. Małkiewicz, Arkadiusz Szarmach, Agnieszka Sabisz, Wiesław J. Cubała, Edyta Szurowska, Paweł J. Winklewski
Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection
Linn Hermansson, Aylin Yilmaz, Markus Axelsson, Kaj Blennow, Dietmar Fuchs, Lars Hagberg, Jan Lycke, Henrik Zetterberg, Magnus Gisslén
Evidence of a distinct peripheral inflammatory profile in sport-related concussion
Alex P. Di Battista, Nathan Churchill, Shawn G. Rhind, Doug Richards, Michael G. Hutchison
JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk
Rebecca L. Openshaw, Jaedeok Kwon, Alison McColl, Josef M. Penninger, Jonathan Cavanagh, Judith A. Pratt, Brian J. Morris
Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review
Larissa Hauer, Slaven Pikija, Eva C. Schulte, Laszlo K. Sztriha, Raffaele Nardone, Johann Sellner
The spleen may be an important target of stem cell therapy for stroke
Zhe Wang, Da He, Ya-Yue Zeng, Li Zhu, Chao Yang, Yong-Juan Lu, Jie-Qiong Huang, Xiao-Yan Cheng, Xiang-Hong Huang, Xiao-Jun Tan
The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction
Xingjuan Chen, Natalie N. Taylor-Nguyen, Ashley M. Riley, B. Paul Herring, Fletcher A. White, Alexander G. Obukhov
CSF1R antagonism limits local restimulation of antiviral CD8+ T cells during viral encephalitis
Kristen E. Funk, Robyn S. Klein
Oligodendrocyte-specific ATF4 inactivation does not influence the development of EAE
Yuan Yue, Milos Stanojlovic, Yifeng Lin, Gerard Karsenty, Wensheng Lin
Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling
Jialin Duan, Jia Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Yan Weng, Ying Yin, Yanhua Wang, Guo Wei, Boling Qiao, Aidong Wen
Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours
A. Saam Youshani, Samuel Rowlston, Claire O’Leary, Gabriella Forte, Helen Parker, Aiyin Liao, Brian Telfer, Kaye Williams, Ian D. Kamaly-Asl, Brian W. Bigger
Co-inhibition of PGF and VEGF blocks their expression in mononuclear phagocytes and limits neovascularization and leakage in the murine retina
Carsten Balser, Anne Wolf, Marc Herb, Thomas Langmann
The role of microglial inflammasome activation in pyroptotic cell death following penetrating traumatic brain injury
Stephanie W. Lee, Juan Pablo de Rivero Vaccari, Jessie S. Truettner, W. Dalton Dietrich, Robert W. Keane
Semaphorin4A causes loss of mature oligodendrocytes and demyelination in vivo
Brian Chiou, Elizabeth Neely, Asha Kallianpur, James R. Connor
TNF-α/STAT3 pathway epigenetically upregulates Nav1.6 expression in DRG and contributes to neuropathic pain induced by L5-VRT
Huan-Huan Ding, Su-Bo Zhang, You-You Lv, Chao Ma, Meng Liu, Kui-Bo Zhang, Xiang-Cai Ruan, Jia-You Wei, Wen-Jun Xin, Shao-Ling Wu
Neuroinflammation and fractalkine signaling in Alzheimer’s disease
Dylan J. Finneran, Kevin R. Nash
Correction to: The atypical RhoGTPase RhoE/Rnd3 is a key molecule to acquire a neuroprotective phenotype in microglia
Veronika E. Neubrand, Irene Forte-Lago, Marta Caro, Mario Delgado
Annexin A1-derived peptide Ac2-26 in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects
Alexandre D. Gimenes, Bruna F. D. Andrade, José Victor P. Pinotti, Sonia M. Oliani, Orfa Y. Galvis-Alonso, Cristiane D. Gil
Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples
Enshan Feng, Tingyu Liang, Xiaoyong Wang, Juan Du, Kai Tang, Xiaoxuan Wang, Fang Wang, Gan You
AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression
Hong-Chun Xiang, Li-Xue Lin, Xue-Fei Hu, He Zhu, Hong-Ping Li, Ru-Yue Zhang, Liang Hu, Wen-Tao Liu, Yi-Lin Zhao, Yang Shu, Hui-Lin Pan, Man Li
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress
Shengchun Xu, Zemin Di, Yufeng He, Runjie Wang, Yuyang Ma, Rui Sun, Jing Li, Tao Wang, Yujun Shen, Shengyun Fang, Lijie Feng, Yuxian Shen
Therapeutic hypercapnia reduces blood–brain barrier damage possibly via protein kinase Cε in rats with lateral fluid percussion injury
Wan-Chao Yang, Qi Wang, Lai-Ting Chi, Yue-Zhen Wang, Hong-Ling Cao, Wen-Zhi Li
Combined utility of white blood cell count and blood glucose for predicting in-hospital outcomes in acute ischemic stroke
Shoujiang You, Zhijie Ou, Wei Zhang, Danni Zheng, Chongke Zhong, Xiaofeng Dong, Chenhong Qiu, Taosheng Lu, Yongjun Cao, Chun-Feng Liu
More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells
Christine Silwedel, Axel Haarmann, Markus Fehrholz, Heike Claus, Christian P. Speer, Kirsten Glaser
Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance
Shoko Morita-Takemura, Kazuki Nakahara, Sanae Hasegawa-Ishii, Ayami Isonishi, Kouko Tatsumi, Hiroaki Okuda, Tatsuhide Tanaka, Masahiro Kitabatake, Toshihiro Ito, Akio Wanaka
CD200-CD200R1 inhibitory signaling prevents spontaneous bacterial infection and promotes resolution of neuroinflammation and recovery after stroke
Rodney M. Ritzel, Abdullah Al Mamun, Joshua Crapser, Rajkumar Verma, Anita R. Patel, Brittany E. Knight, Nia Harris, Nickolas Mancini, Meaghan Roy-O’Reilly, Bhanu Priya Ganesh, Fudong Liu, Louise D. McCullough
Iron accentuated reactive oxygen species release by NADPH oxidase in activated microglia contributes to oxidative stress in vitro
Young J. Yauger, Sara Bermudez, Kasey E. Moritz, Ethan Glaser, Bogdan Stoica, Kimberly R. Byrnes
Chemokines and matrix metalloproteinases in cerebrospinal fluid of patients with central nervous system complications caused by varicella-zoster virus
Liza Lind, Kristina Eriksson, Anna Grahn
The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia
Kristin Mages, Felix Grassmann, Herbert Jägle, Rainer Rupprecht, Bernhard H. F. Weber, Stefanie M. Hauck, Antje Grosche
Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer’s disease
Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, Maria F. Massenti, Marta Di Carlo, Carla Cannizzaro, Giovanni Cassata, Luca Cicero, Maria Ruscica, Natale Belluardo, Luigi M. Grimaldi
Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis
John D. Lee, Ning Liu, Samantha C. Levin, Lars Ottosson, Ulf Andersson, Helena E. Harris, Trent M. Woodruff
Glial activation and inflammation along the Alzheimer’s disease continuum
Kaja Nordengen, Bjørn-Eivind Kirsebom, Kristi Henjum, Per Selnes, Berglind Gísladóttir, Marianne Wettergreen, Silje Bøen Torsetnes, Gøril Rolfseng Grøntvedt, Knut K. Waterloo, Dag Aarsland, Lars N. G. Nilsson, Tormod Fladby
Activation of retinoid X receptor by bexarotene attenuates neuroinflammation via PPARγ/SIRT6/FoxO3a pathway after subarachnoid hemorrhage in rats
Yuchun Zuo, Lei Huang, Budbazar Enkhjargal, Weilin Xu, Ocak Umut, Zachary D. Travis, Guangyu Zhang, Jiping Tang, Fei Liu, John H. Zhang
Astrocytic ceramide as possible indicator of neuroinflammation
Nienke M. de Wit, Sandra den Hoedt, Pilar Martinez-Martinez, Annemieke J. Rozemuller, Monique T. Mulder, Helga E. de Vries
Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity
Martina Ott, Erika Avendaño-Guzmán, Evelyn Ullrich, Carolin Dreyer, Judith Strauss, Markus Harden, Margarete Schön, Michael P. Schön, Günter Bernhardt, Christine Stadelmann, Christiane Wegner, Wolfgang Brück, Stefan Nessler
Genetic variability of inflammation and oxidative stress genes does not play a major role in the occurrence of adverse events of dopaminergic treatment in Parkinson’s disease
Sara Redenšek, Dušan Flisar, Maja Kojović, Milica Gregorič Kramberger, Dejan Georgiev, Zvezdan Pirtošek, Maja Trošt, Vita Dolžan
Myelinoclastic diffuse sclerosis (Schilder’s disease) is immunologically distinct from multiple sclerosis: results from retrospective analysis of 92 lumbar punctures
S. Jarius, J. Haas, F. Paul, B. Wildemann
Amlexanox attenuates experimental autoimmune encephalomyelitis by inhibiting dendritic cell maturation and reprogramming effector and regulatory T cell responses
Mo-Yuan Quan, Xiu-Juan Song, Hui-Jia Liu, Xiao-Hong Deng, Hui-Qing Hou, Li-Ping Chen, Tian-Zhao Ma, Xu Han, Xin-Xin He, Zhen Jia, Li Guo
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis
Qianquan Ma, Changsheng Xing, Wenyong Long, Helen Y. Wang, Qing Liu, Rong-Fu Wang
FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
Laurent Kremer, Omar Taleb, Nelly Boehm, Ayikoe Guy Mensah-Nyagan, Elisabeth Trifilieff, Jérôme de Seze, Susana Brun
Murine astrocytes produce IL-24 and are susceptible to the immunosuppressive effects of this cytokine
Amanda R. Burmeister, M. Brittany Johnson, Jessica J. Yaemmongkol, Ian Marriott
Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage
Marc Durocher, Bradley P. Ander, Glen Jickling, Farah Hamade, Heather Hull, Bodie Knepp, Da Zhi Liu, Xinhua Zhan, Anh Tran, Xiyuan Cheng, Kwan Ng, Alan Yee, Frank R. Sharp, Boryana Stamova
CD55 upregulation in astrocytes by statins as potential therapy for AQP4-IgG seropositive neuromyelitis optica
Lukmanee Tradtrantip, Tianjiao Duan, Michael R. Yeaman, Alan S. Verkman
Intrathecal triamcinolone acetonide exerts anti-inflammatory effects on Lewis rat experimental autoimmune neuritis and direct anti-oxidative effects on Schwann cells
Kalliopi Pitarokoili, Melissa Sgodzai, Thomas Grüter, Hussein Bachir, Jeremias Motte, Björn Ambrosius, Xiomara Pedreiturria, Min-Suk Yoon, Ralf Gold
Cerebrospinal fluid biomarkers for predicting development of multiple sclerosis in acute optic neuritis: a population-based prospective cohort study
M. N. Olesen, K. Soelberg, B. Debrabant, A. C. Nilsson, S. T. Lillevang, J. Grauslund, I. Brandslund, J. S. Madsen, F. Paul, T. J. Smith, S. Jarius, N. Asgari
Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
Thomas Taetzsch, Savannah Benusa, Shannon Levesque, Christen L. Mumaw, Michelle L. Block
Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits
Lien Beckers, Ivana Geric, Stijn Stroobants, Sander Beel, Philip Van Damme, Rudi D’Hooge, Myriam Baes
Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice
Zhuo Gong, Jingyi Huang, Biao Xu, Zhenri Ou, Le Zhang, Xiaohong Lin, Xiujuan Ye, Xuejian Kong, Dahong Long, Xiangdong Sun, Xiaosong He, Liping Xu, Qingqing Li, Aiguo Xuan
Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome
Marc A. Russo, Nathan T. Fiore, Caryn van Vreden, Dominic Bailey, Danielle M. Santarelli, Helen M. McGuire, Barbara Fazekas de St Groth, Paul J. Austin
Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation
Laurine Becquet, Catalina Abad, Mathilde Leclercq, Camille Miel, Laetitia Jean, Gaëtan Riou, Alain Couvineau, Olivier Boyer, Yossan-Var Tan
Visualizing neuroinflammation with fluorescence and luminescent lanthanide-based in situ hybridization
Lindsay M. Parker, Nima Sayyadi, Vasiliki Staikopoulos, Ashish Shrestha, Mark R. Hutchinson, Nicolle H. Packer
Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures
Yi Sun, Jiangjun Ma, Dongfang Li, Pinggan Li, Xiaolin Zhou, Yu Li, Zhanwen He, Lijun Qin, Liyang Liang, Xiangyang Luo
Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome
Masaya Yasui, Yuki Menjyo, Kyohei Tokizane, Akiko Shiozawa, Makoto Tsuda, Kazuhide Inoue, Hiroshi Kiyama
Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study
Kimberly D. van der Willik, Lana Fani, Dimitris Rizopoulos, Silvan Licher, Jesse Fest, Sanne B. Schagen, M. Kamran Ikram, M. Arfan Ikram
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice
Matthew McMillin, Stephanie Grant, Gabriel Frampton, Anca D. Petrescu, Elaina Williams, Brandi Jefferson, Alison Thomas, Ankita Brahmaroutu, Sharon DeMorrow
Correction to: Expansion and activation of distinct central memory T lymphocyte subsets in complex regional pain syndrome
Marc A. Russo, Nathan T. Fiore, Caryn van Vreden, Dominic Bailey, Danielle M. Santarelli, Helen M. McGuire, Barbara Fazekas de St Groth, Paul J. Austin
HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways
Feng Zhou, Xiaomei Liu, Lin Gao, Xinxin Zhou, Qianwen Cao, Liping Niu, Jing Wang, Dongjiao Zuo, Xiangyang Li, Ying Yang, Minmin Hu, Yinghua Yu, Renxian Tang, Bong Ho Lee, Byoung Wook Choi, Yugang Wang, Yoshihiro Izumiya, Min Xue, Kuiyang Zheng, Dianshuai Gao
Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?
Yanan Xie, Yingzhe Wang, Hongyan Ding, Min Guo, Xun Wang, Qiang Dong, Mei Cui
Anti-CNTN1 IgG3 induces acute conduction block and motor deficits in a passive transfer rat model
Kathrin Doppler, Yasmin Schuster, Luise Appeltshauser, Lydia Biko, Carmen Villmann, Andreas Weishaupt, Christian Werner, Claudia Sommer
Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
Dawling A. Dionisio-Santos, John A. Olschowka, M. Kerry O’Banion
LncRNA-1810034E14Rik reduces microglia activation in experimental ischemic stroke
Xi Zhang, Xiao-Lei Zhu, Bi-Ying Ji, Xiang Cao, Lin-Jie Yu, Yan Zhang, Xin-Yu Bao, Yun Xu, Jia-Li Jin
The role of microglia in viral encephalitis: a review
Zhuangzhuang Chen, Di Zhong, Guozhong Li
Myosin1f-mediated neutrophil migration contributes to acute neuroinflammation and brain injury after stroke in mice
Yan Wang, Haojie Jin, Weifang Wang, Feng Wang, Heng Zhao
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model
Wei He, Ting Long, Qi Pan, Shanshan Zhang, Yixin Zhang, Dunke Zhang, Guangcheng Qin, Lixue Chen, Jiying Zhou
Transiently proliferating perivascular microglia harbor M1 type and precede cerebrovascular changes in a chronic hypertension model
Takashi Koizumi, Katsutoshi Taguchi, Ikuko Mizuta, Hiroe Toba, Makoto Ohigashi, Okihiro Onishi, Kazuya Ikoma, Seiji Miyata, Tetsuo Nakata, Masaki Tanaka, Sébastien Foulquier, Harry W. M. Steinbusch, Toshiki Mizuno
TNFα inhibitors as targets for protective therapies in MSA: a viewpoint
Alain Ndayisaba, Kurt Jellinger, Thomas Berger, Gregor K. Wenning
A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
Ram Kuwar, Andrew Rolfe, Long Di, Hongyu Xu, Liu He, Yuqi Jiang, Shijun Zhang, Dong Sun
GPR34 in spinal microglia exacerbates neuropathic pain in mice
Akira Sayo, Hiroyuki Konishi, Masaaki Kobayashi, Kuniyuki Kano, Hiroki Kobayashi, Hideharu Hibi, Junken Aoki, Hiroshi Kiyama
Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain
Danli Zhou, Siqi Zhang, Liang Hu, Yu-Feng Gu, Yimei Cai, Deqin Wu, Wen-Tao Liu, Chun-Yi Jiang, Xiangqing Kong, Guang-Qin Zhang
Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10/β-endorphin pathway
Xiao-Fang Mao, Hai-Yun Wu, Xue-Qi Tang, Usman Ali, Hao Liu, Yong-Xiang Wang
Macrophage migration inhibitory factor facilitates prostaglandin E2 production of astrocytes to tune inflammatory milieu following spinal cord injury
Yuxin Zhang, Yue Zhou, Shuxia Chen, Yuming Hu, Zhenjie Zhu, Yingjie Wang, Nan Du, Tiancheng Song, Yumin Yang, Aisong Guo, Yongjun Wang
Dysregulation of sonic hedgehog pathway and pericytes in the brain after lentiviral infection
Diana G. Bohannon, Allen Ko, Adam R. Filipowicz, Marcelo J. Kuroda, Woong-Ki Kim
Ultrastructural evidence of microglial heterogeneity in Alzheimer’s disease amyloid pathology
Hassan El Hajj, Julie C. Savage, Kanchan Bisht, Martin Parent, Luc Vallières, Serge Rivest, Marie-Ève Tremblay
HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke
Antonino Tuttolomondo, Domenico Di Raimondo, Rosaria Pecoraro, Alessandra Casuccio, Danilo Di Bona, Anna Aiello, Giulia Accardi, Valentina Arnao, Giuseppe Clemente, Vittoriano Della Corte, Carlo Maida, Irene Simonetta, Calogero Caruso, Rosario Squatrito, Antonio Pinto, Antonino Tuttolomondo, Domenico Di Raimondo, Danilo Di Bona, Calogero Caruso, Antonio Pinto
Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy
Giorgia Moschetti, Giada Amodeo, Daniela Maftei, Roberta Lattanzi, Patrizia Procacci, Patrizia Sartori, Gianfranco Balboni, Valentina Onnis, Vincenzo Conte, Alberto Panerai, Paola Sacerdote, Silvia Franchi
Role of inflammation in depression relapse
Chun-Hong Liu, Guang-Zhong Zhang, Bin Li, Meng Li, Marie Woelfer, Martin Walter, Lihong Wang
Role of NADPH oxidase-2 in the progression of the inflammatory response secondary to striatum excitotoxic damage
Diego Rolando Hernández-Espinosa, Lourdes Massieu, Teresa Montiel, Julio Morán
Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner
Bei Zhang, Guoqing Wang, Jingyi He, Qiuyu Yang, Daidi Li, Jingjie Li, Feng Zhang
Sustained interleukin-10 delivery reduces inflammation and improves motor function after spinal cord injury
Daniel J. Hellenbrand, Kaitlyn A. Reichl, Benjamin J. Travis, Mallory E. Filipp, Andrew S. Khalil, Domenic J. Pulito, Ashley V. Gavigan, Elizabeth R. Maginot, Mitchell T. Arnold, Alexander G. Adler, William L. Murphy, Amgad S. Hanna
Plasma VCAM1 levels correlate with disease severity in Parkinson’s disease
Caroline Perner, Florian Perner, Nayana Gaur, Silke Zimmermann, Otto W. Witte, Florian H. Heidel, Julian Grosskreutz, Tino Prell
Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K/AKT/FoxO1 pathway
Li-Ting Guo, Si-Qi Wang, Jing Su, Li-Xing Xu, Zhou-Ye Ji, Ru-Yi Zhang, Qin-Wen Zhao, Zhan-Qiang Ma, Xue-Yang Deng, Shi-Ping Ma
Deficiency of TREK-1 potassium channel exacerbates blood-brain barrier damage and neuroinflammation after intracerebral hemorrhage in mice
Yongkang Fang, Yeye Tian, Qibao Huang, Yue Wan, Li Xu, Wei Wang, Dengji Pan, Suiqiang Zhu, Minjie Xie
Experimental necrotizing enterocolitis induces neuroinflammation in the neonatal brain
George Biouss, Lina Antounians, Bo Li, Joshua S. O’Connell, Shogo Seo, Vincenzo D. Catania, Jennifer Guadagno, Abidur Rahman, Elke Zani-Ruttenstock, Nataliia Svergun, Agostino Pierro, Augusto Zani
Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice
Josh M. Morganti, Danielle S. Goulding, Linda J. Van Eldik
Osteopontin and its spatiotemporal relationship with glial cells in the striatum of rats treated with mitochondrial toxin 3-nitropropionic acid: possible involvement in phagocytosis
Tae-Ryong Riew, Soojin Kim, Xuyan Jin, Hong Lim Kim, Jeong-Hwa Lee, Mun-Yong Lee
Morphine immunomodulation prolongs inflammatory and postoperative pain while the novel analgesic ZH853 accelerates recovery and protects against latent sensitization
Amy K. Feehan, James E. Zadina
Meningitic Escherichia coli-induced upregulation of PDGF-B and ICAM-1 aggravates blood-brain barrier disruption and neuroinflammatory response
Rui-Cheng Yang, Xin-Yi Qu, Si-Yu Xiao, Liang Li, Bo-Jie Xu, Ji-Yang Fu, Yu-Jin Lv, Nouman Amjad, Chen Tan, Kwang Sik Kim, Huan-Chun Chen, Xiang-Ru Wang
Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
Kjetil Bårdsen, Cato Brede, Ingeborg Kvivik, Jan Terje Kvaløy, Kristin Jonsdottir, Anne Bolette Tjensvoll, Peter Ruoff, Roald Omdal
HDAC3 inhibition prevents blood-brain barrier permeability through Nrf2 activation in type 2 diabetes male mice
Qiuchen Zhao, Fang Zhang, Zhanyang Yu, Shuzhen Guo, Ning Liu, Yinghua Jiang, Eng H. Lo, Yun Xu, Xiaoying Wang
Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation
Xili Chu, Lili Cao, Zhuoya Yu, Danqing Xin, Tingting Li, Weiwei Ma, Xin Zhou, Wenqiang Chen, Dexiang Liu, Zhen Wang
Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia
Sabrina Hupp, Denis Grandgirard, Timothy J. Mitchell, Stephen L. Leib, Lucy J. Hathaway, Asparouh I. Iliev
Lipopolysaccharide-induced neuroinflammation induces presynaptic disruption through a direct action on brain tissue involving microglia-derived interleukin 1 beta
Olivia Sheppard, Michael P. Coleman, Claire S. Durrant
Proteoglycans involved in bidirectional communication between mast cells and hippocampal neurons
Juan Antonio Flores, María Pilar Ramírez-Ponce, María Ángeles Montes, Santiago Balseiro-Gómez, Jorge Acosta, Guillermo Álvarez de Toledo, Eva Alés
Antibiotics, gut microbiota, and Alzheimer’s disease
Francesco Angelucci, Katerina Cechova, Jana Amlerova, Jakub Hort
Differential neuro-immune patterns in two clinically relevant murine models of multiple sclerosis
Krista D. DiSano, Michael R. Linzey, Darlene B. Royce, Andrew R. Pachner, Francesca Gilli
Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway
Min Jian, Jason Shing-Cheong Kwan, Myriam Bunting, Roy Chun-Laam Ng, Koon Ho Chan
Contribution of LTi and TH17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis
Verena Schropp, Jörn Rohde, Damiano M. Rovituso, Samir Jabari, Richa Bharti, Stefanie Kuerten
Augmented β2-adrenergic signaling dampens the neuroinflammatory response following ischemic stroke and increases stroke size
Kendra J. Lechtenberg, Scott T. Meyer, Janelle B. Doyle, Todd C. Peterson, Marion S. Buckwalter
Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice
Sergio M. Borghi, Victor Fattori, Felipe A. Pinho-Ribeiro, Talita P. Domiciano, Milena M. Miranda-Sapla, Tiago H. Zaninelli, Rubia Casagrande, Phileno Pinge-Filho, Wander R. Pavanelli, Jose C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha, Waldiceu A. Verri Jr
TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)
Xing-Liang Yang, Xin Wang, Lin Shao, Guang-Tong Jiang, Jia-Wei Min, Xi-Yu Mei, Xiao-Hua He, Wan-Hong Liu, Wen-Xian Huang, Bi-Wen Peng
CCL20-CCR6 axis modulated traumatic brain injury-induced visual pathologies
Mahasweta Das, Xiaolan Tang, Jung Yeon Han, Karthick Mayilsamy, Elspeth Foran, Manas R. Biswal, Radouil Tzekov, Shyam S. Mohapatra, Subhra Mohapatra
Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke
Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju
The antidepressant effects of GM-CSF are mediated by the reduction of TLR4/NF-ĸB-induced IDO expression
Sara Hemmati, Mohammad Amin Sadeghi, Razieh Mohammad Jafari, Hasan Yousefi-Manesh, Ahmad Reza Dehpour
Reactive microglia and IL1β/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
Levi Todd, Isabella Palazzo, Lilianna Suarez, Xiaoyu Liu, Leo Volkov, Thanh V. Hoang, Warren A. Campbell, Seth Blackshaw, Ning Quan, Andy J. Fischer
Correction to: Exosomes derived from atorvastatin-modified bone marrow dendritic cells ameliorate experimental autoimmune myasthenia gravis by up-regulated levels of IDO/Treg and partly dependent on FasL/Fas pathway
Xiao-Li Li, Heng Li, Min Zhang, Hua Xu, Long-Tao Yue, Xin-Xin Zhang, Shan Wang, Cong-Cong Wang, Yan-Bin Li, Ying-Chun Dou, Rui-Sheng Duan
Leucine-rich repeat kinase-2 (LRRK2) modulates paraquat-induced inflammatory sickness and stress phenotype
Chris Rudyk, Zach Dwyer, Shawn Hayley, E Schurr, Earl Brown, Derrick Gibbings, Shawn Hayley, David Park, Dana C Philpott, John D Rioux, Michael Schlossmacher
NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes
Pu Hong, Ruo-Nan Gu, Feng-Xian Li, Xiao-Xing Xiong, Wen-Bin Liang, Zhi-Jian You, Hong-Fei Zhang
The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage
Olga Romantsik, Alex Adusei Agyemang, Snjolaug Sveinsdóttir, Sigurbjörg Rutardóttir, Bo Holmqvist, Magnus Cinthio, Mattias Mörgelin, Gulcin Gumus, Helena Karlsson, Stefan R. Hansson, Bo Åkerström, David Ley, Magnus Gram
Soluble epoxide hydrolase modulates immune responses in activated astrocytes involving regulation of STAT3 activity
Chia-Chi Hung, Yi-Hsuan Lee, Yi-Min Kuo, Pei-Chien Hsu, Huey-Jen Tsay, Ying-Ting Hsu, Chih-Chin Lee, Jia-Jun Liang, Feng-Shiun Shie
BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury
Judith Sánchez-Ventura, Jesús Amo-Aparicio, Xavier Navarro, Clara Penas
Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation
Mateus R. Amorim, Júnia L. de Deus, Rafael A. Cazuza, Clarissa M. D. Mota, Luiz E. V. da Silva, Gabriela S. Borges, Marcelo E. Batalhão, Evelin C. Cárnio, Luiz G. S. Branco
A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis
Gabriella Contarini, Davide Franceschini, Laura Facci, Massimo Barbierato, Pietro Giusti, Morena Zusso
Cytokine inflammatory threat, but not LPS one, shortens GABAergic synaptic currents in the mouse spinal cord organotypic cultures
Vincenzo Giacco, Giulia Panattoni, Manuela Medelin, Elena Bonechi, Alessandra Aldinucci, Clara Ballerini, Laura Ballerini
Altered gut microbiota and inflammatory cytokine responses in patients with Parkinson’s disease
Chin-Hsien Lin, Chieh-Chang Chen, Han-Lin Chiang, Jyh-Ming Liou, Chih-Min Chang, Tzu-Pin Lu, Eric Y. Chuang, Yi-Cheng Tai, Chieh Cheng, Han-Yi Lin, Ming-Shiang Wu
Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation
Juan M. Ilarregui, Gijs Kooij, Ernesto Rodríguez, Susanne M. A. van der Pol, Nathalie Koning, Hakan Kalay, Joost C. van der Horst, Sandra J. van Vliet, Juan J. García-Vallejo, Helga E. de Vries, Yvette van Kooyk
Correlation between auto/mitophagic processes and magnetic resonance imaging activity in multiple sclerosis patients
Massimiliano Castellazzi, Simone Patergnani, Mariapina Donadio, Carlotta Giorgi, Massimo Bonora, Enrico Fainardi, Ilaria Casetta, Enrico Granieri, Maura Pugliatti, Paolo Pinton
Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain
Yu-Jiao Li, Kun Zhang, Ting Sun, Jian Wang, Yan-Yan Guo, Le Yang, Qi Yang, Yan-Jiao Li, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei Wu
T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response
Heejoo Kim, Laura Dickey, Colleen Stone, Jillian L. Jafek, Thomas E. Lane, Dean Tantin
Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease
Alvaro Cobo-Calvo, María Sepúlveda, Fabien Rollot, Thais Armangué, Anne Ruiz, Elisabeth Maillart, Caroline Papeix, Bertrand Audoin, Helene Zephir, Damien Biotti, Jonathan Ciron, Francoise Durand-Dubief, Nicolas Collongues, Xavier Ayrignac, Pierre Labauge, Eric Thouvenot, Bertrand Bourre, Alexis Montcuquet, Mikael Cohen, Romain Deschamps, Nuria Solà-Valls, Sara Llufriu, Jerome De Seze, Yolanda Blanco, Sandra Vukusic, Albert Saiz, Romain Marignier
C3aR signaling and gliosis in response to neurodevelopmental damage in the cerebellum
Kevin G. Young, Keqin Yan, David J. Picketts
TLR4 participates in the transmission of ethanol-induced neuroinflammation via astrocyte-derived extracellular vesicles
Francesc Ibáñez, Jorge Montesinos, Juan R. Ureña-Peralta, Consuelo Guerri, María Pascual
New therapeutic targeting of Alzheimer’s disease with the potential use of proline-rich polypeptide complex to modulate an innate immune response - preliminary study
Marta Sochocka, Michał Ochnik, Maciej Sobczyński, Iwona Siemieniec, Beata Orzechowska, Piotr Naporowski, Jerzy Leszek
STAT3 activation in circulating myeloid-derived cells contributes to retinal microvascular dysfunction in diabetes
Mei Chen, Gideon Obasanmi, David Armstrong, Nuala-Jane Lavery, Adrien Kissenpfennig, Noemi Lois, Heping Xu
Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model
Songyun Wang, Lin Wu, Xuemeng Li, Binxun Li, Yi Zhai, Dongdong Zhao, Hong Jiang
An update on reactive astrocytes in chronic pain
Ting Li, Xuhui Chen, Chuanhan Zhang, Yue Zhang, Wenlong Yao
The effects of human immunoglobulin G on enhancing tissue protection and neurobehavioral recovery after traumatic cervical spinal cord injury are mediated through the neurovascular unit
Jonathon Chon Teng Chio, Jian Wang, Anna Badner, James Hong, Vithushan Surendran, Michael G. Fehlings
Neuroinflammation: friend and foe for ischemic stroke
Richard L. Jayaraj, Sheikh Azimullah, Rami Beiram, Fakhreya Y. Jalal, Gary A. Rosenberg
Malva parviflora extract ameliorates the deleterious effects of a high fat diet on the cognitive deficit in a mouse model of Alzheimer’s disease by restoring microglial function via a PPAR-γ-dependent mechanism
Elisa Medrano-Jiménez, Itzia Jiménez-Ferrer Carrillo, Martha Pedraza-Escalona, Cristina E. Ramírez-Serrano, Lourdes Álvarez-Arellano, Javier Cortés-Mendoza, Maribel Herrera-Ruiz, Enrique Jiménez-Ferrer, Alejandro Zamilpa, Jaime Tortoriello, Gustavo Pedraza-Alva, Leonor Pérez-Martínez
Long-term voluntary wheel running does not alter vascular amyloid burden but reduces neuroinflammation in the Tg-SwDI mouse model of cerebral amyloid angiopathy
Lisa S. Robison, Dominique L. Popescu, Maria E. Anderson, Nikita Francis, Joshua Hatfield, Joseph K. Sullivan, Steven I. Beigelman, Feng Xu, Brenda J. Anderson, William E. Van Nostrand, John K. Robinson
Plasma YKL-40 in the spectrum of neurodegenerative dementia
Anna Villar-Piqué, Matthias Schmitz, Peter Hermann, Stefan Goebel, Timothy Bunck, Daniela Varges, Isidre Ferrer, Joachim Riggert, Franc Llorens, Inga Zerr
CCAAT/enhancer-binding protein delta regulates the stemness of glioma stem-like cells through activating PDGFA expression upon inflammatory stimulation
Shao-Ming Wang, Hong-Yi Lin, Yen-Lin Chen, Tsung-I Hsu, Jian-Ying Chuang, Tzu-Jen Kao, Chiung-Yuan Ko
Neuroinvasion of Toxocara canis- and T. cati-larvae mediates dynamic changes in brain cytokine and chemokine profile
Patrick Waindok, Christina Strube
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
Morena Zusso, Valentina Lunardi, Davide Franceschini, Andrea Pagetta, Rita Lo, Stefano Stifani, Anna Chiara Frigo, Pietro Giusti, Stefano Moro
Mdivi-1, a mitochondrial fission inhibitor, modulates T helper cells and suppresses the development of experimental autoimmune encephalomyelitis
Yan-Hua Li, Fang Xu, Rodolfo Thome, Min-Fang Guo, Man-Luan Sun, Guo-Bin Song, Rui-lan Li, Zhi Chai, Bogoljub Ciric, A. M. Rostami, Mark Curtis, Cun-Gen Ma, Guang-Xian Zhang
Peripheral and central compensatory mechanisms for impaired vagus nerve function during peripheral immune activation
Anna Kobrzycka, Paweł Napora, Brandon L. Pearson, Krystyna Pierzchała-Koziec, Rafał Szewczyk, Marek Wieczorek
The retinal environment induces microglia-like properties in recruited myeloid cells
Scott W. McPherson, Neal D. Heuss, Ute Lehmann, Heidi Roehrich, Md. Abedin, Dale S. Gregerson
Differential transcriptional profiles identify microglial- and macrophage-specific gene markers expressed during virus-induced neuroinflammation
Ana Beatriz DePaula-Silva, Carlos Gorbea, Daniel J. Doty, Jane E. Libbey, John Michael S. Sanchez, Tyler J. Hanak, Demián Cazalla, Robert S. Fujinami
Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson’s disease
Penelope J. Hallett, Simone Engelender, Ole Isacson
Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study
Frederike C. Oertel, Olivier Outteryck, Benjamin Knier, Hanna Zimmermann, Nadja Borisow, Judith Bellmann-Strobl, Astrid Blaschek, Sven Jarius, Markus Reindl, Klemens Ruprecht, Edgar Meinl, Reinhard Hohlfeld, Friedemann Paul, Alexander U. Brandt, Tania Kümpfel, Joachim Havla
In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study
Sanhita Sinharay, Tsang-Wei Tu, Zsofia I. Kovacs, William Schreiber-Stainthorp, Maggie Sundby, Xiang Zhang, Georgios Z. Papadakis, William C. Reid, Joseph A. Frank, Dima A. Hammoud
Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis
Lukas Muri, Ngoc Dung Le, Jonas Zemp, Denis Grandgirard, Stephen L. Leib
Mo-derived perivascular macrophage recruitment protects against endothelial cell death in retinal vein occlusion
Christophe Roubeix, Elisa Dominguez, William Raoul, Xavier Guillonneau, Michel Paques, José-Alain Sahel, Florian Sennlaub
Systemic TLR2 tolerance enhances central nervous system remyelination
Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter, Robert B. Clark
Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner
Timothy French, Henning Peter Düsedau, Johannes Steffen, Aindrila Biswas, Norus Ahmed, Susanne Hartmann, Thomas Schüler, Björn H. Schott, Ildiko Rita Dunay
Tranexamic acid reduces heme cytotoxicity via the TLR4/TNF axis and ameliorates functional recovery after spinal cord injury
Shingo Yoshizaki, Ken Kijima, Masamitsu Hara, Takeyuki Saito, Tetsuya Tamaru, Masatake Tanaka, Dai-jiro Konno, Yasuharu Nakashima, Seiji Okada
A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
Angela S. Gupta, Debolina D. Biswas, La Shardai N. Brown, Karli Mockenhaupt, Michael Marone, Andrew Hoskins, Ulrich Siebenlist, Tomasz Kordula
Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese
Kotaro Ogawa, Tatsusada Okuno, Kazuyoshi Hosomichi, Akiko Hosokawa, Jun Hirata, Ken Suzuki, Saori Sakaue, Makoto Kinoshita, Yoshihiro Asano, Katsuichi Miyamoto, Ituro Inoue, Susumu Kusunoki, Yukinori Okada, Hideki Mochizuki
Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury
Tobias J. Krämer, Nathalia Hack, Till J. Brühl, Lutz Menzel, Regina Hummel, Eva-Verena Griemert, Matthias Klein, Serge C. Thal, Tobias Bopp, Michael K. E. Schäfer
Neuroinflammatory astrocytes generated from cord blood-derived human induced pluripotent stem cells
Qiong Zhou, Coralie Viollet, Anastasia Efthymiou, Guzal Khayrullina, Kasey E. Moritz, Matthew D. Wilkerson, Gauthaman Sukumar, Clifton L. Dalgard, Martin L. Doughty
Butyrate suppresses demyelination and enhances remyelination
Tong Chen, Daisuke Noto, Yasunobu Hoshino, Miho Mizuno, Sachiko Miyake
Beneficial effects of curtailing immune susceptibility in an Alzheimer’s disease model
Giulia Di Benedetto, Chiara Burgaletto, Anna R. Carta, Salvatore Saccone, Laurence Lempereur, Giovanna Mulas, Carla Loreto, Renato Bernardini, Giuseppina Cantarella
Clinical and immunological control of experimental autoimmune encephalomyelitis by tolerogenic dendritic cells loaded with MOG-encoding mRNA
Judith Derdelinckx, María José Mansilla, Maxime De Laere, Wai-Ping Lee, Juan Navarro-Barriuso, Inez Wens, Irene Nkansah, Jasmijn Daans, Hans De Reu, Aneta Jolanta Keliris, Johan Van Audekerke, Verdi Vanreusel, Zoë Pieters, Annemie Van der Linden, Marleen Verhoye, Geert Molenberghs, Niel Hens, Herman Goossens, Barbara Willekens, Patrick Cras, Peter Ponsaerts, Zwi N. Berneman, Eva María Martínez-Cáceres, Nathalie Cools
Lipocalin-2 may produce damaging effect after cerebral ischemia by inducing astrocytes classical activation
Nan Zhao, Xiaomeng Xu, Yongjun Jiang, Jie Gao, Fang Wang, Xiaohui Xu, Zhuoyu Wen, Yi Xie, Juanji Li, Rongrong Li, Qiushi Lv, Qian Liu, Qiliang Dai, Xinfeng Liu, Gelin Xu
Transcriptome profiling of brain myeloid cells revealed activation of Itgal, Trem1, and Spp1 in western diet-induced obesity
Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Lysophosphatidic acid receptor 1 (LPA1) plays critical roles in microglial activation and brain damage after transient focal cerebral ischemia
Bhakta Prasad Gaire, Arjun Sapkota, Mi-Ryoung Song, Ji Woong Choi
The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis
Jiangyuan Gao, Jing Z. Cui, Aikun Wang, Hao Hang Rachel Chen, Alison Fong, Joanne A. Matsubara
Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide
Sarah K. Baker, Zu-Lin Chen, Erin H. Norris, Sidney Strickland
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain
Junjun Ni, Zhou Wu, Jie Meng, Takashi Saito, Takaomi C. Saido, Hong Qing, Hiroshi Nakanishi
Viral-mediated gene delivery of TMBIM6 protects the neonatal brain via disruption of NPR-CYP complex coupled with upregulation of Nrf-2 post-HI
Desislava Doycheva, Ningbo Xu, Jiping Tang, John Zhang
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling
Wei Cai, Julie Wang, Mengyan Hu, Xiao Chen, Zhengqi Lu, Joseph A. Bellanti, Song Guo Zheng
Correction to: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury
Tobias J. Krämer, Nathalia Hack, Till J. Brühl, Lutz Menzel, Regina Hummel, Eva-Verena Griemert, Matthias Klein, Serge C. Thal, Tobias Bopp, Michael K. E. Schäfer
Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells
Emina Hayashida, Zheng Lung Ling, Thomas M. Ashhurst, Barney Viengkhou, So Ri Jung, Pattama Songkhunawej, Phillip K. West, Nicholas J. C. King, Markus J. Hofer
Neuroinflammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles
Sylwia Dabrowska, Anna Andrzejewska, Barbara Lukomska, Miroslaw Janowski
Long-term use of interferon-β in multiple sclerosis increases Vδ1−Vδ2−Vγ9− γδ T cells that are associated with a better outcome
Guzailiayi Maimaitijiang, Mitsuru Watanabe, Koji Shinoda, Noriko Isobe, Yuri Nakamura, Katsuhisa Masaki, Takuya Matsushita, Yasunobu Yoshikai, Jun-ichi Kira
Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway
Weidong Liang, Chunshui Lin, Liuqing Yuan, Li Chen, Peipei Guo, Ping Li, Wei Wang, Xin Zhang
Baricitinib reverses HIV-associated neurocognitive disorders in a SCID mouse model and reservoir seeding in vitro
Christina Gavegnano, Woldeab B. Haile, Selwyn Hurwitz, Sijia Tao, Yong Jiang, Raymond F. Schinazi, William R. Tyor
TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development
Xuebin Qu, Jingjing Han, Ying Zhang, Xingqi Wang, Hongbin Fan, Fang Hua, Ruiqin Yao
A small peptide antagonist of the Fas receptor inhibits neuroinflammation and prevents axon degeneration and retinal ganglion cell death in an inducible mouse model of glaucoma
Anitha Krishnan, Andrew J. Kocab, David N. Zacks, Ann Marshak-Rothstein, Meredith Gregory-Ksander
Nrf-2 signaling inhibits intracranial aneurysm formation and progression by modulating vascular smooth muscle cell phenotype and function
Yuan Shi, Sichen Li, Yaying Song, Peixi Liu, Zixiao Yang, Yingjun Liu, Kai Quan, Guo Yu, Zhiyuan Fan, Wei Zhu
Plasma neurofilament light chain and amyloid-β are associated with the kynurenine pathway metabolites in preclinical Alzheimer’s disease
Pratishtha Chatterjee, Henrik Zetterberg, Kathryn Goozee, Chai K. Lim, Kelly R. Jacobs, Nicholas J. Ashton, Abdul Hye, Steve Pedrini, Hamid R. Sohrabi, Tejal Shah, Prita R. Asih, Preeti Dave, Kaikai Shen, Kevin Taddei, David B. Lovejoy, Gilles J. Guillemin, Kaj Blennow, Ralph N. Martins
Aryl hydrocarbon receptor modulates stroke-induced astrogliosis and neurogenesis in the adult mouse brain
Wan-Ci Chen, Li-Hsin Chang, Shiang-Suo Huang, Yu-Jie Huang, Chun-Lien Chih, Hung-Chih Kuo, Yi-Hsuan Lee, I-Hui Lee
Dynamic response of microglia/macrophage polarization following demyelination in mice
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai
Activated spinal astrocytes contribute to the later phase of carrageenan-induced prostatitis pain
Guo-Chuang Deng, Ming Lu, Ya-Yu Zhao, Ying Yuan, Gang Chen
Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT/STAT3 signaling
Ka-Young Ryu, Hyun-ju Lee, Hanwoong Woo, Ri-Jin Kang, Kyung-Min Han, HyunHee Park, Sang Min Lee, Ju-Young Lee, Yoo Joo Jeong, Hyun-Wook Nam, Youngpyo Nam, Hyang-Sook Hoe
Effects of VEGF blockade on the dynamics of the inflammatory landscape in glioblastoma-bearing mice
Aurélie Soubéran, Sophie Brustlein, Caroline Gouarné, Lionel Chasson, Aurélie Tchoghandjian, Marie Malissen, Geneviève Rougon
NDP-MSH binding melanocortin-1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NF-κB pathway after intracerebral hemorrhage in mice
Xuan Wu, Siming Fu, Yun Liu, Hansheng Luo, Feng Li, Yiying Wang, Meng Gao, Yuan Cheng, Zongyi Xie
The broad spectrum mixed-lineage kinase 3 inhibitor URMC-099 prevents acute microgliosis and cognitive decline in a mouse model of perioperative neurocognitive disorders
Patrick Miller-Rhodes, Cuicui Kong, Gurpreet S. Baht, Priyanka Saminathan, Ramona M. Rodriguiz, William C. Wetsel, Harris A. Gelbard, Niccolò Terrando
Potential biomarkers for neuroinflammation and neurodegeneration at short and long term after neonatal hypoxic-ischemic insult in rat
Nozha Borjini, Sandra Sivilia, Alessandro Giuliani, Mercedes Fernandez, Luciana Giardino, Fabrizio Facchinetti, Laura Calzà
Estrogen-induced compensatory mechanisms protect IL-10-deficient mice from developing EAE
Hilary A. Seifert, Grant Gerstner, Gail Kent, Arthur A. Vandenbark, Halina Offner
MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology
Javier H. Jara, Mukesh Gautam, Nuran Kocak, Edward F. Xie, Qinwen Mao, Eileen H. Bigio, P. Hande Özdinler
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Chitra Rawat, Samiksha Kukal, Ujjwal Ranjan Dahiya, Ritushree Kukreti
CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia
Rong Jin, Wei Zhong, Shan Liu, Guohong Li
Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants
Maho Tsubota, Ryotaro Fukuda, Yusuke Hayashi, Takaya Miyazaki, Shin Ueda, Rika Yamashita, Nene Koike, Fumiko Sekiguchi, Hidenori Wake, Shuji Wakatsuki, Yuka Ujiie, Toshiyuki Araki, Masahiro Nishibori, Atsufumi Kawabata
Acute peripheral immune activation alters cytokine expression and glial activation in the early postnatal rat brain
Matthew Bruce, Karin M. Streifel, Casey A. Boosalis, Luke Heuer, Eduardo A. González, Shuyang Li, Danielle J. Harvey, Pamela J. Lein, Judy Van de Water
Effect of Enterococcus faecalis 2001 on colitis and depressive-like behavior in dextran sulfate sodium-treated mice: involvement of the brain–gut axis
Kohei Takahashi, Osamu Nakagawasai, Wataru Nemoto, Takayo Odaira, Wakana Sakuma, Hiroshi Onogi, Hiroaki Nishijima, Ryuji Furihata, Yukio Nemoto, Hiroyuki Iwasa, Koichi Tan-No, Takeshi Tadano
Exosomes derived from statin-modified bone marrow dendritic cells increase thymus-derived natural regulatory T cells in experimental autoimmune myasthenia gravis
Peng Zhang, Ru-Tao Liu, Tong Du, Chun-Lin Yang, Yu-Dong Liu, Meng-Ru Ge, Min Zhang, Xiao-Li Li, Heng Li, Ying-Chun Dou, Rui-Sheng Duan
Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis
Andrés Cruz-Herranz, Michael Dietrich, Alexander M. Hilla, Hao H. Yiu, Marc H. Levin, Christina Hecker, Andrea Issberner, Angelika Hallenberger, Christian Cordano, Klaus Lehmann-Horn, Lisanne J. Balk, Orhan Aktas, Jens Ingwersen, Charlotte von Gall, Hans-Peter Hartung, Scott S. Zamvil, Dietmar Fischer, Philipp Albrecht, Ari J. Green
The link between chronic pain and Alzheimer’s disease
Song Cao, Daniel W. Fisher, Tain Yu, Hongxin Dong
Changes in cytokine and chemokine profiles in mouse serum and brain, and in human neural cells, upon tick-borne encephalitis virus infection
Petra Pokorna Formanova, Martin Palus, Jiri Salat, Vaclav Hönig, Michal Stefanik, Pavel Svoboda, Daniel Ruzek
Quercetin prevents necroptosis of oligodendrocytes by inhibiting macrophages/microglia polarization to M1 phenotype after spinal cord injury in rats
Hong Fan, Hai-Bin Tang, Le-Qun Shan, Shi-Chang Liu, Da-Geng Huang, Xun Chen, Zhe Chen, Ming Yang, Xin-Hua Yin, Hao Yang, Ding-Jun Hao
Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2)
Ersilia Mirabelli, Li Ni, Lun Li, Cigdem Acioglu, Robert F. Heary, Stella Elkabes
Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
Satoru Yamagishi, Yurika Iga, Masato Nakamura, Chika Takizawa, Dai Fukumoto, Takeharu Kakiuchi, Shingo Nishiyama, Hiroyuki Ohba, Hideo Tsukada, Kohji Sato, Yasuomi Ouchi
Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1
Xiaojuan Liu, Raquel Tonello, Yuejuan Ling, Yong-Jing Gao, Temugin Berta
Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage
Elizabeth A. Kowalski, Jiang Chen, Amanda Hazy, Lauren E. Fritsch, Erwin Kristobal Gudenschwager-Basso, Michael Chen, Xia Wang, Yun Qian, Mingjun Zhou, Matthew Byerly, Alicia M. Pickrell, John B. Matson, Irving Coy Allen, Michelle H. Theus
Potential link between the RagA-mTOR-p70S6K axis and depressive-behaviors during bacterial liposaccharide challenge
Jia Zhao, Lixing Lao, Wei Cui, Jianhui Rong
Regulatory impairment in untreated Parkinson’s disease is not restricted to Tregs: other regulatory populations are also involved
Diana D. Álvarez-Luquín, Asiel Arce-Sillas, Jaquelín Leyva-Hernández, Edgar Sevilla-Reyes, Marie Catherine Boll, Esteban Montes-Moratilla, Viridiana Vivas-Almazán, Citzielli Pérez-Correa, Ulises Rodríguez-Ortiz, Raquel Espinoza-Cárdenas, Gladis Fragoso, Edda Sciutto, Laura Adalid-Peralta
Inflammation in delayed ischemia and functional outcomes after subarachnoid hemorrhage
Sung-Ho Ahn, Jude P. J. Savarraj, Kaushik Parsha, Georgene W. Hergenroeder, Tiffany R. Chang, Dong H. Kim, Ryan S. Kitagawa, Spiros L. Blackburn, H. Alex Choi
TRPV1 translocated to astrocytic membrane to promote migration and inflammatory infiltration thus promotes epilepsy after hypoxic ischemia in immature brain
Xin Wang, Xing-Liang Yang, Wei-Lin Kong, Meng-Liu Zeng, Lin Shao, Guang-Tong Jiang, Jing-Jing Cheng, Shuo Kong, Xiao-Hua He, Wan-Hong Liu, Tao-Xiang Chen, Bi-Wen Peng
Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis
Barakat Alrashdi, Bassel Dawod, Andrea Schampel, Sabine Tacke, Stefanie Kuerten, Jean S. Marshall, Patrice D. Côté
Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats
Sylwia Dabrowska, Anna Andrzejewska, Damian Strzemecki, Maurizio Muraca, Miroslaw Janowski, Barbara Lukomska
P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
Feng Jing, Yixin Zhang, Ting Long, Wei He, Guangcheng Qin, Dunke Zhang, Lixue Chen, Jiying Zhou
Tempol improves neuroinflammation and delays motor dysfunction in a mouse model (SOD1G93A) of ALS
Gabriela Bortolança Chiarotto, Luciana Politti Cartarozzi, Matheus Perez, Natalia Perussi Biscola, Aline Barroso Spejo, Fernanda Gubert, Marcondes França Junior, Rosália Mendez-Otero, Alexandre Leite Rodrigues de Oliveira
Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases
Gildas Lepennetier, Zsuzsanna Hracsko, Marina Unger, Martijn Van Griensven, Verena Grummel, Markus Krumbholz, Achim Berthele, Bernhard Hemmer, Markus C. Kowarik
Analysis of miRNA signatures in CSF identifies upregulation of miR-21 and miR-146a/b in patients with multiple sclerosis and active lesions
María Muñoz-San Martín, Gemma Reverter, Rene Robles-Cedeño, Maria Buxò, Francisco José Ortega, Imma Gómez, Jordi Tomàs-Roig, Naiara Celarain, Luisa María Villar, Hector Perkal, José Manuel Fernández-Real, Ester Quintana, Lluís Ramió-Torrentà
Cellular source of hypothalamic macrophage accumulation in diet-induced obesity
Chan Hee Lee, Sung Hoon Shin, Gil Myoung Kang, Seongjun Kim, Jiye Kim, Rina Yu, Min-Seon Kim
Interleukin 1 alpha administration is neuroprotective and neuro-restorative following experimental ischemic stroke
Kathleen E. Salmeron, Michael E. Maniskas, Danielle N. Edwards, Raymond Wong, Ivana Rajkovic, Amanda Trout, Abir A. Rahman, Samantha Hamilton, Justin F. Fraser, Emmanuel Pinteaux, Gregory J. Bix
Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE)
Timothy N. Friedman, Muhammad Saad Yousuf, Ana Catuneanu, Mansi Desai, Camille A. Juźwik, Alyson E. Fournier, Bradley J. Kerr
Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction
Mu-Hui Fu, I-Chun Chen, Chou-Hwei Lee, Chih-Wei Wu, Yu-Chi Lee, Yu Chih Kung, Chun-Ying Hung, Kay L. H. Wu
GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine
Taeyeop Park, Huazhen Chen, Hee-Yong Kim
Chemerin-induced macrophages pyroptosis in fetal brain tissue leads to cognitive disorder in offspring of diabetic dams
Zhaoxia Liang, Luyang Han, Dianjianyi Sun, Yanmin Chen, Qi Wu, Lixia Zhang, Menglin Zhou, Danqing Chen
Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2/Stat3 pathway after stroke
Xiao Cheng, Patrick K. K. Yeung, Ke Zhong, Prince L. M. Zilundu, Lihua Zhou, Sookja K. Chung
Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients
Jan W. Traub, Hannah L. Pellkofer, Katja Grondey, Ira Seeger, Christoph Rowold, Wolfgang Brück, Leila Husseini, Silke Häusser-Kinzel, Martin S. Weber
Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons
Clayton W. Winkler, Tyson A. Woods, Bradley R. Groveman, Aaron B. Carmody, Emily E. Speranza, Craig A. Martens, Sonja M. Best, Cathryn L. Haigh, Karin E. Peterson
Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice
Weixing Zhao, Zhipeng Xu, Jiangbei Cao, Qiang Fu, Yishuang Wu, Xiaoying Zhang, Yue Long, Xuan Zhang, Yitian Yang, Yunfeng Li, Weidong Mi
Immunomodulatory and anti-inflammatory effects of probiotics in multiple sclerosis: a systematic review
Mohammad Morshedi, Reza Hashemi, Sara Moazzen, Amirhossein Sahebkar, Elaheh-Sadat Hosseinifard
Distinct migratory pattern of naive and effector T cells through the blood–CSF barrier following Echovirus 30 infection
Marie Wiatr, Carolin Stump-Guthier, Daniela Latorre, Stefanie Uhlig, Christel Weiss, Jorma Ilonen, Britta Engelhardt, Hiroshi Ishikawa, Christian Schwerk, Horst Schroten, Tobias Tenenbaum, Henriette Rudolph
Midbrain microglia mediate a specific immunosuppressive response under inflammatory conditions
Miguel Angel Abellanas, Marta Zamarbide, Leyre Basurco, Esther Luquin, Marta Garcia-Granero, Pedro Clavero, Patxi San Martin-Uriz, Amaia Vilas, Elisa Mengual, Sandra Hervas-Stubbs, Maria S. Aymerich
The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage
Xiaowei Fei, Yeting He, Jia Chen, Weitao Man, Chen Chen, Kai Sun, Boyun Ding, Chongwu Wang, Ruxiang Xu
Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex
Shi-Yang Ye, Joanna E. Apple, Xiao Ren, Fu-Lei Tang, Ling-Ling Yao, Yong-Gang Wang, Lin Mei, Yuan-Guo Zhou, Wen-Cheng Xiong
Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
Divaker Choubey
The effects of n-6 polyunsaturated fatty acid deprivation on the inflammatory gene response to lipopolysaccharide in the mouse hippocampus
Shoug M. Alashmali, Lin Lin, Marc-Olivier Trépanier, Giulia Cisbani, Richard P. Bazinet
Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice
Chao Wang, Lu Zhang, Jean De La Croix Ndong, Aubryanna Hettinghouse, Guodong Sun, Changhong Chen, Chen Zhang, Ronghan Liu, Chuan-ju Liu
Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis
Ruixi Zhou, Xiaoyan Yang, Xihong Li, Yi Qu, Qun Huang, Xuemei Sun, Dezhi Mu
Monocarboxylate transporter 1 promotes classical microglial activation and pro-inflammatory effect via 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3
Liang Kong, Zehua Wang, Xiaohong Liang, Yue Wang, Lifen Gao, Chunhong Ma
Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy
Daniel S. Kikuchi, Ana Carolina P. Campos, Hongyan Qu, Steven J. Forrester, Rosana L. Pagano, Bernard Lassègue, Ruxana T. Sadikot, Kathy K. Griendling, Marina S. Hernandes
The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke
Yilong Shan, Sha Tan, Yinyao Lin, Siyuan Liao, Bingjun Zhang, Xiaodong Chen, Jihui Wang, Zhezhi Deng, Qin Zeng, Lei Zhang, Yuge Wang, Xueqiang Hu, Wei Qiu, Lisheng Peng, Zhengqi Lu
DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage
Tao Tao, Guang-Jie Liu, Xuan Shi, Yan Zhou, Yue Lu, Yong-Yue Gao, Xiang-Sheng Zhang, Han Wang, Ling-Yun Wu, Chun-Lei Chen, Zong Zhuang, Wei Li, Chun-Hua Hang
Anti-MOG autoantibodies pathogenicity in children and macaques demyelinating diseases
Che Serguera, Lev Stimmer, Claire-Maelle Fovet, Philippe Horellou, Vanessa Contreras, Nicolas Tchitchek, Julie Massonneau, Carole Leroy, Audrey Perrin, Julien Flament, Philippe Hantraye, Joanna Demilly, Romain Marignier, Pascale Chrétien, Bert‘t Hart, Jean Boutonnat, Clovis Adam, Roger Le-Grand, Kumaran Deiva
Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors
María del Mar Fernández-Arjona, Jesús M. Grondona, Pedro Fernández-Llebrez, María Dolores López-Ávalos
The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models
Yu-Young Lee, Jin-Sun Park, Yea-Hyun Leem, Jung-Eun Park, Do-Yeon Kim, Youn-Hee Choi, Eun-Mi Park, Jihee Lee Kang, Hee-Sun Kim
Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats
Weilin Xu, Tao Li, Liansheng Gao, Jingwei Zheng, Jun Yan, Jianmin Zhang, Anwen Shao
HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0
Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction
Xiao-Yu Sun, Teng Zheng, Xiu Yang, Le Liu, Shen-Shen Gao, Han-Bing Xu, Yu-Tong Song, Kun Tong, Li Yang, Ya Gao, Tong Wu, Jing-Ru Hao, Chen Lu, Tao Ma, Can Gao
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
Rachael H. Earls, Kelly B. Menees, Jaegwon Chung, James Barber, Claire-Anne Gutekunst, Manuel G. Hazim, Jae-Kyung Lee
IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
Josy Augustine, Sofia Pavlou, Imran Ali, Kevin Harkin, Ema Ozaki, Matthew Campbell, Alan W. Stitt, Heping Xu, Mei Chen
Folate receptor-targeted positron emission tomography of experimental autoimmune encephalomyelitis in rats
Petri Elo, Xiang-Guo Li, Heidi Liljenbäck, Semi Helin, Jarmo Teuho, Kalle Koskensalo, Virva Saunavaara, Päivi Marjamäki, Vesa Oikonen, Jenni Virta, Qingshou Chen, Philip S. Low, Juhani Knuuti, Sirpa Jalkanen, Laura Airas, Anne Roivainen
Innate immunity activation in the early brain injury period following subarachnoid hemorrhage
Typhaine Gris, Patrick Laplante, Paméla Thebault, Romain Cayrol, Ahmed Najjar, Benjamin Joannette-Pilon, Frédéric Brillant-Marquis, Elsa Magro, Shane W. English, Réjean Lapointe, Michel Bojanowski, Charles L. Francoeur, Jean-François Cailhier
Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment
Debjani Guha, David R. Lorenz, Vikas Misra, Sukrutha Chettimada, Susan Morgello, Dana Gabuzda
The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration
Dezhen Tu, Yun Gao, Ru Yang, Tian Guan, Jau-Shyong Hong, Hui-Ming Gao
Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke
Degang Song, Xiangjian Zhang, Junmin Chen, Xiaoxia Liu, Jing Xue, Lan Zhang, Xifa Lan
Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines
Paola Pontecorvi, Michael A. Banki, Carlotta Zampieri, Cristina Zalfa, Pardis Azmoon, Maria Z. Kounnas, Cinzia Marchese, Steven L. Gonias, Elisabetta Mantuano
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
Andro Montoya, Daniela Elgueta, Javier Campos, Ornella Chovar, Paulina Falcón, Soledad Matus, Iván Alfaro, María Rosa Bono, Rodrigo Pacheco
Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis
Roberta Magliozzi, Owain William Howell, Pascal Durrenberger, Eleonora Aricò, Rachel James, Carolina Cruciani, Cheryl Reeves, Federico Roncaroli, Richard Nicholas, Richard Reynolds
URB597 protects against NLRP3 inflammasome activation by inhibiting autophagy dysfunction in a rat model of chronic cerebral hypoperfusion
Shao-Hua Su, Yi-Fang Wu, Qi Lin, Da-Peng Wang, Jian Hai
IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
Fátima Rivera-Escalera, Jonathan J. Pinney, Laura Owlett, Hoda Ahmed, Juilee Thakar, John A. Olschowka, Michael R. Elliott, M. Kerry O’Banion
TGFβRI antagonist inhibits HIV-1 Nef-induced CC chemokine family ligand 2 (CCL2) in the brain and prevents spatial learning impairment
Gladys Chompre, Neysha Martinez-Orengo, Myrella Cruz, James T. Porter, Richard J. Noel Jr
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
Yuanyuan Li, Mengyue Niu, Aonan Zhao, Wenyan Kang, Zhichun Chen, Ningdi Luo, Liche Zhou, Xiongwei Zhu, Liming Lu, Jun Liu
Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer’s disease animal model
Mudan Cai, Jun-Hwan Lee, Eun Jin Yang
Maternal elevated salt consumption and the development of autism spectrum disorder in the offspring
Kazi Farhana Afroz, Karina Alviña
Stress-induced microglial activation occurs through β-adrenergic receptor: noradrenaline as a key neurotransmitter in microglial activation
Shuei Sugama, Takato Takenouchi, Makoto Hashimoto, Hisayuki Ohata, Yasuhiro Takenaka, Yoshihiko Kakinuma
Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer’s disease
Hsueh-Te Lee, Kuan-I Lee, Chia-Hui Chen, Tzong-Shyuan Lee
Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem
Darine Fakih, Zhanlin Zhao, Pierre Nicolle, Elodie Reboussin, Fanny Joubert, Jade Luzu, Antoine Labbé, William Rostène, Christophe Baudouin, Stéphane Mélik Parsadaniantz, Annabelle Réaux-Le Goazigo
Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C
Samuel D. Shin, Alexandra Shin, Karina Mayagoitia, Lorraine Siebold, Marsilio Rubini, Christopher G. Wilson, Denise L. Bellinger, Salvador Soriano
Association of LAG3 genetic variation with an increased risk of PD in Chinese female population
Wenyuan Guo, Miaomiao Zhou, Jiewen Qiu, Yuwan Lin, Xiang Chen, Shuxuan Huang, Mingshu Mo, Hanqun Liu, Guoyou Peng, Xiaoqin Zhu, Pingyi Xu
Intrathecal injection of bone marrow stromal cells attenuates neuropathic pain via inhibition of P2X4R in spinal cord microglia
Yongbo Teng, Yang Zhang, Shouwei Yue, Huanwen Chen, Yujuan Qu, Hui Wei, Xiaofeng Jia
Molecular biomarkers in multiple sclerosis
Tjalf Ziemssen, Katja Akgün, Wolfgang Brück
The potassium channel KCa3.1 represents a valid pharmacological target for microgliosis-induced neuronal impairment in a mouse model of Parkinson’s disease
Jia Lu, Fangfang Dou, Zhihua Yu
Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity
Stefania Petrosino, Aniello Schiano Moriello, Roberta Verde, Marco Allarà, Roberta Imperatore, Alessia Ligresti, Ali Mokhtar Mahmoud, Alessio Filippo Peritore, Fabio Arturo Iannotti, Vincenzo Di Marzo
Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site
Meenakshisundaram Balasubramaniam, Paul A. Parcon, Chhanda Bose, Ling Liu, Richard A. Jones, Martin R. Farlow, Robert E. Mrak, Steven W. Barger, W. Sue T. Griffin
Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury
Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker
KS23, a novel peptide derived from adiponectin, inhibits retinal inflammation and downregulates the proportions of Th1 and Th17 cells during experimental autoimmune uveitis
Tian Niu, Lu Cheng, Hanying Wang, Shaopin Zhu, Xiaolu Yang, Kun Liu, Huiyi Jin, Xun Xu
Complement factor H contributes to mortality in humans and mice with bacterial meningitis
E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek
The history of neuromyelitis optica. Part 2: ‘Spinal amaurosis’, or how it all began
S. Jarius, B. Wildemann
BAP31 regulates IRAK1-dependent neuroinflammation in microglia
Xia Liu, Kun Jiao, Cong-cong Jia, Guo-xun Li, Qing Yuan, Ji-kai Xu, Yue Hou, Bing Wang
CXCR5-negative natural killer cells ameliorate experimental autoimmune myasthenia gravis by suppressing follicular helper T cells
Chun-Lin Yang, Peng Zhang, Ru-Tao Liu, Na Zhang, Min Zhang, Heng Li, Tong Du, Xiao-Li Li, Ying-Chun Dou, Rui-Sheng Duan
Lentivirus-mediated downregulation of α-synuclein reduces neuroinflammation and promotes functional recovery in rats with spinal cord injury
Hong Zeng, Nan Liu, Yan-yan Yang, Hua-yi Xing, Xiao-xie Liu, Fang Li, Gao-yan La, Meng-jie Huang, Mou-wang Zhou
Time course of neuropathological events in hyperhomocysteinemic amyloid depositing mice reveals early neuroinflammatory changes that precede amyloid changes and cerebrovascular events
Erica M. Weekman, Tiffany L. Sudduth, Brittani R. Price, Abigail E. Woolums, Danielle Hawthorne, Charles E. Seaks, Donna M. Wilcock