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Zeitschrift

Journal of Translational Medicine

Journal of Translational Medicine 1/2011

Ausgabe 1/2011

Inhaltsverzeichnis ( 223 Artikel )

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Optical Nerve Detection by Diffuse Reflectance Spectroscopy for Feedback Controlled Oral and Maxillofacial Laser Surgery

Florian Stelzle, Azhar Zam, Werner Adler, Katja Tangermann-Gerk, Alexandre Douplik, Emeka Nkenke, Michael Schmidt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil

María Sánchez-Aragó, José M Cuezva

01.12.2011 | Research | Ausgabe 1/2011 Open Access

CXC receptor-4 mRNA silencing abrogates CXCL12-induced migration of colorectal cancer cells

Claudia Rubie, Vilma O Frick, Pirus Ghadjar, Mathias Wagner, Christoph Justinger, Sabrina K Faust, Benjamin Vicinus, Stefan Gräber, Otto Kollmar, Martin K Schilling

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Time-course of sFlt-1 and VEGF-A release in neutropenic patients with sepsis and septic shock: a prospective study

Brunna E Alves, Silmara AL Montalvao, Francisco JP Aranha, Irene Lorand-Metze, Carmino A De Souza, Joyce M Annichino-Bizzacchi, Erich V De Paula

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Increase of plasma IL-9 and decrease of plasma IL-5, IL-7, and IFN-γ in patients with chronic heart failure

Claudia Cappuzzello, Luca Di Vito, Roberta Melchionna, Guido Melillo, Lorena Silvestri, Eleonora Cesareo, Filippo Crea, Giovanna Liuzzo, Antonio Facchiano, Maurizio C Capogrossi, Monica Napolitano

01.12.2011 | Research | Ausgabe 1/2011 Open Access

MiRNA-205 modulates cellular invasion and migration via regulating zinc finger E-box binding homeobox 2 expression in esophageal squamous cell carcinoma cells

Kayoko Matsushima, Hajime Isomoto, Naoyuki Yamaguchi, Naoki Inoue, Haruhisa Machida, Toshiyuki Nakayama, Tomayoshi Hayashi, Masaki Kunizaki, Shigekazu Hidaka, Takeshi Nagayasu, Masahiro Nakashima, Kenta Ujifuku, Norisato Mitsutake, Akira Ohtsuru, Shunichi Yamashita, Manav Korpal, Yibin Kang, Philip A Gregory, Gregory J Goodall, Shigeru Kohno, Kazuhiko Nakao

01.12.2011 | Research | Ausgabe 1/2011 Open Access

High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area

Tai-Jan Chiu, Chang-Han Chen, Chih-Yen Chien, Shau-Hsuan Li, Hsin-Ting Tsai, Yi-Ju Chen

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Future perspectives in melanoma research. Meeting report from the "Melanoma Research: a bridge Naples-USA. Naples, December 6 th -7 th 2010"

Paolo A Ascierto, Eleonora De Maio, Stefano Bertuzzi, Giuseppe Palmieri, Ruth Halaban, Mary Hendrix, Mohamed Kashani-sabet, Soldano Ferrone, Ena Wang, Alistair Cochran, Licia Rivoltini, Peter P Lee, Bernard A Fox, John M Kirkwood, Claudio Dansky Ullmann, Frederic F Lehmann, Mario Sznol, Douglas J Schwartzentruber, Michele Maio, Keith Flaherty, Jerome Galon, Antoni Ribas, James Yang, David F Stroncek, Nicola Mozzillo, Franco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

In vitro migration of cytotoxic T lymphocyte derived from a colon carcinoma patient is dependent on CCL2 and CCR2

Klara Berencsi, Pyapalli Rani, Tianqian Zhang, Laura Gross, Michael Mastrangelo, Neal J Meropol, Dorothee Herlyn, Rajasekharan Somasundaram

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Tumor escape and progression of HER-2/neu negative breast cancer under immune pressure

Maciej Kmieciak, Kyle K Payne, Michael O Idowu, Margaret M Grimes, Laura Graham, Maria-Libera Ascierto, Ena Wang, Xiang-Yang Wang, Harry D Bear, Masoud H Manjili

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy

Wenxue Ma, Trevor Smith, Vladimir Bogin, Yu Zhang, Cengiz Ozkan, Mihri Ozkan, Melanie Hayden, Stephanie Schroter, Ewa Carrier, Davorka Messmer, Vipin Kumar, Boris Minev

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Insertion of the human sodium iodide symporter to facilitate deep tissue imaging does not alter oncolytic or replication capability of a novel vaccinia virus

Dana Haddad, Nanhai G Chen, Qian Zhang, Chun-Hao Chen, Yong A Yu, Lorena Gonzalez, Susanne G Carpenter, Joshua Carson, Joyce Au, Arjun Mittra, Mithat Gonen, Pat B Zanzonico, Yuman Fong, Aladar A Szalay

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Rational design of HIV vaccines and microbicides: report of the EUROPRISE network annual conference 2010

Sarah Brinckmann, Kelly da Costa, Marit J van Gils, David Hallengärd, Katja Klein, Luisa Madeira, Lara Mainetti, Paolo Palma, Katharina Raue, David Reinhart, Marc Reudelsterz, Nicolas Ruffin, Janna Seifried, Katrein Schäfer, Enas Sheik-Khalil, Annette Sköld, Hannes Uchtenhagen, Nicolas Vabret, Serena Ziglio, Gabriella Scarlatti, Robin Shattock, Britta Wahren, Frances Gotch

01.12.2011 | Research | Ausgabe 1/2011 Open Access

15 kDa Granulysin versus GM-CSF for monocytes differentiation: analogies and differences at the transcriptome level

Luciano Castiello, David F Stroncek, Michael W Finn, Ena Wang, Francesco M Marincola, Carol Clayberger, Alan M Krensky, Marianna Sabatino

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Elevated expression of CDK4 in lung cancer

Aibing Wu, Bin Wu, Jinsong Guo, Weiren Luo, Dong Wu, Huiling Yang, Yan Zhen, Xiaoli Yu, Hao Wang, Ying Zhou, Zhen Liu, Weiyi Fang, Zhixiong Yang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Gene therapy with tumor-specific promoter mediated suicide gene plus IL-12 gene enhanced tumor inhibition and prolonged host survival in a murine model of Lewis lung carcinoma

Yu Xu, Jinxuan Hou, Zhengchun Liu, Haijun Yu, Wenjie Sun, Jie Xiong, Zhengkai Liao, Fuxiang Zhou, Conghua Xie, Yunfeng Zhou

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Histone modification enhances the effectiveness of IL-13 receptor targeted immunotoxin in murine models of human pancreatic cancer

Toshio Fujisawa, Bharat H Joshi, Raj K Puri

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Cancer stem cell subsets and their relationships

Hai-Guang Liu, Chong Chen, Han Yang, Yi-Fei Pan, Xiao-Hua Zhang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Differentiation associated regulation of microRNA expression in vivo in human CD8+ T cell subsets

Bruno Salaun, Takuya Yamamoto, Bassam Badran, Yasuko Tsunetsugu-Yokota, Antoine Roux, Lukas Baitsch, Redouane Rouas, Hussein Fayyad-Kazan, Petra Baumgaertner, Estelle Devevre, Anirudh Ramesh, Marion Braun, Daniel Speiser, Brigitte Autran, Philippe Martiat, Victor Appay, Pedro Romero

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an experimental study

Li Tang, Lie-Jun Mei, Xiao-Jun Yang, Chao-Qun Huang, Yun-Feng Zhou, Yutaka Yonemura, Yan Li

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Tian Sheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Boon Hwa Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique PV de Kleijn, Sai Kiang Lim

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Detection and characterization of translational research in cancer and cardiovascular medicine

David S Jones, Alberto Cambrosio, Andrei Mogoutov

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

Valentina Durastanti, Alessandra Lugaresi, Placido Bramanti, Mariapia Amato, Paolo Bellantonio, Giovanna De Luca, Orietta Picconi, Roberta Fantozzi, Laura Locatelli, Annalisa Solda', Edoardo Sessa, Rocco Totaro, Silvia Marino, Valentina Zipoli, Marino Zorzon, Enrico Millefiorini

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A novel multiplex assay combining autoantibodies plus PSA has potential implications for classification of prostate cancer from non-malignant cases

Chong Xie, Hyun J Kim, Jonathan G Haw, Anusha Kalbasi, Brian K Gardner, Gang Li, Jianyu Rao, David Chia, Monty Liong, Rubio R Punzalan, Leonard S Marks, Allan J Pantuck, Alexandre de la Taille, Guomin Wang, Hideki Mukouyama, Gang Zeng

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes

Yi Li, Gang Ren, Yan-Xiang Wang, Wei-Jia Kong, Peng Yang, Yue-Ming Wang, Ying-Hong Li, Hong Yi, Zhuo-Rong Li, Dan-Qing Song, Jian-Dong Jiang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma

Zhizhong Xu, Guobo Shen, Xiangying Xia, Xinyu Zhao, Peng Zhang, Huanhuan Wu, Qingfa Guo, Zhiyong Qian, Yuquan Wei, Shufang Liang

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

High throughput RNAi assay optimization using adherent cell cytometry

Christoph S Nabzdyk, Maggie Chun, Leena Pradhan, Frank W LoGerfo

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells

Elisabetta Cavalieri, Antonella Rigo, Massimiliano Bonifacio, Alessandra Carcereri de Prati, Emanuele Guardalben, Christian Bergamini, Romana Fato, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction

Yen-Ta Chen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Yung-Lung Chen, Tzu-Hsien Tsai, Sheng-Ying Chung, Sarah Chua, Ying-Hsien Kao, Chia-Hung Yen, Pei-Lin Shao, Kuan-Cheng Chang, Steve Leu, Hon-Kan Yip

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Safety and pharmacokinetics of recombinant human hepatocyte growth factor (rh-HGF) in patients with fulminant hepatitis: a phase I/II clinical trial, following preclinical studies to ensure safety

Akio Ido, Akihiro Moriuchi, Masatsugu Numata, Toshinori Murayama, Satoshi Teramukai, Hiroyuki Marusawa, Naohisa Yamaji, Hitoshi Setoyama, Il-Deok Kim, Tsutomu Chiba, Shuji Higuchi, Masayuki Yokode, Masanori Fukushima, Akira Shimizu, Hirohito Tsubouchi

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Resveratrol prevents inflammation-dependent hepatic melanoma metastasis by inhibiting the secretion and effects of interleukin-18

Clarisa Salado, Elvira Olaso, Natalia Gallot, Maria Valcarcel, Eider Egilegor, Lorea Mendoza, Fernando Vidal-Vanaclocha

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Therapeutic effects of pyrrolidine dithiocarbamate on acute lung injury in rabbits

Meitang Wang, Tao Liu, Dian Wang, Yonghua Zheng, Xiangdong Wang, Jian He

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Human umbilical cord blood-derived mononuclear cell transplantation: case series of 30 subjects with Hereditary Ataxia

Wan-Zhang Yang, Yun Zhang, Fang Wu, Min Zhang, SC Cho, Chun-Zhen Li, Shao-Hui Li, Guo-Jian Shu, You-Xiang Sheng, Ning Zhao, Ying Tang, Shu Jiang, Shan Jiang, Matthew Gandjian, Thomas E Ichim, Xiang Hu

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Prostate transglutaminase (TGase-4) antagonizes the anti-tumour action of MDA-7/IL-24 in prostate cancer

Richard J Ablin, Howard G Kynaston, Malcolm D Mason, Wen G Jiang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke

Raquel Rodríguez-González, Tomás Sobrino, Manuel Rodríguez-Yáñez, Mónica Millán, David Brea, Elena Miranda, Octavio Moldes, Juan Pérez, David A Lomas, Rogelio Leira, Antoni Dávalos, José Castillo

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Interferon signaling patterns in peripheral blood lymphocytes may predict clinical outcome after high-dose interferon therapy in melanoma patients

Diana L Simons, Gerald Lee, John M Kirkwood, Peter P Lee

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Create a translational medicine knowledge repository - Research downsizing, mergers and increased outsourcing have reduced the depth of in-house translational medicine expertise and institutional memory at many pharmaceutical and biotech companies: how will they avoid relearning old lessons?

Bruce H Littman, Francesco M Marincola

01.12.2011 | Meeting report | Ausgabe 1/2011 Open Access

Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer

James M Balwit, Pawel Kalinski, Vernon K Sondak, Pierre G Coulie, Elizabeth M Jaffee, Thomas F Gajewski, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Concomitant detection of IFNα signature and activated monocyte/dendritic cell precursors in the peripheral blood of IFNα-treated subjects at early times after repeated local cytokine treatments

Eleonora Aricò, Luciano Castiello, Francesca Urbani, Paola Rizza, Monica C Panelli, Ena Wang, Francesco M Marincola, Filippo Belardelli

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274

Jinxuan Hou, Jixin Dong, Lijun Sun, Liying Geng, Jing Wang, Jialin Zheng, Yan Li, Julia Bridge, Steven H Hinrichs, Shi-Jian Ding

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Improvement of cardiac contractile function by peptide-based inhibition of NF-κB in the utrophin/dystrophin-deficient murine model of muscular dystrophy

Dawn A Delfín, Ying Xu, Jennifer M Peterson, Denis C Guttridge, Jill A Rafael-Fortney, Paul ML Janssen

01.12.2011 | Research | Ausgabe 1/2011 Open Access

SULFs in human neoplasia: implication as progression and prognosis factors

Caroline Bret, Jérôme Moreaux, Jean-François Schved, Dirk Hose, Bernard Klein

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells

Duo-Rong Xu, Shan Huang, Zi-Jie Long, Jia-Jie Chen, Zheng-Zhi Zou, Juan Li, Dong-Jun Lin, Quentin Liu

01.12.2011 | Review | Ausgabe 1/2011 Open Access

The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting

Alessandra Maleddu, Maria A Pantaleo, Margherita Nannini, Guido Biasco

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations

Franziska Niehr, Erika von Euw, Narsis Attar, Deliang Guo, Doug Matsunaga, Hooman Sazegar, Charles Ng, John A Glaspy, Juan A Recio, Roger S Lo, Paul S Mischel, Begonya Comin-Anduix, Antoni Ribas

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Plasma proteome changes in cardiovascular disease patients: novel isoforms of apolipoprotein A1

Pavel Májek, Zuzana Reicheltová, Jiří Suttnar, Martin Malý, Milan Oravec, Klára Pečánková, Jan E Dyr

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

An NIH intramural percubator as a model of academic-industry partnerships: from the beginning of life through the valley of death

Michael R Emmert-Buck

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells

Jia Rao, Duo-Rong Xu, Fei-Meng Zheng, Zi-Jie Long, Sheng-Shan Huang, Xing Wu, Wei-Hua Zhou, Ren-Wei Huang, Quentin Liu

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Time-dependent cytotoxic drugs selectively cooperate with IL-18 for cancer chemo-immunotherapy

Ioannis Alagkiozidis, Andrea Facciabene, Marinos Tsiatas, Carmine Carpenito, Fabian Benencia, Sarah Adams, Zdenka Jonak, Carl H June, Daniel J Powell Jr, George Coukos

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Understanding tumor heterogeneity as functional compartments - superorganisms revisited

Thomas GP Grunewald, Saskia M Herbst, Jürgen Heinze, Stefan Burdach

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Body fluid derived exosomes as a novel template for clinical diagnostics

Sascha Keller, Johannes Ridinger, Anne-Kathleen Rupp, Johannes WG Janssen, Peter Altevogt

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

Negative enrichment by immunomagnetic nanobeads for unbiased characterization of circulating tumor cells from peripheral blood of cancer patients

Zhian Liu, Alberto Fusi, Eva Klopocki, Alexander Schmittel, Ingeborg Tinhofer, Anika Nonnenmacher, Ulrich Keilholz

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Recombinant HPV16 E7 assembled into particles induces an immune response and specific tumour protection administered without adjuvant in an animal model

Linda Petrone, Maria G Ammendolia, Armando Cesolini, Stefano Caimi, Fabiana Superti, Colomba Giorgi, Paola Di Bonito

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The combined transduction of copper, zinc-superoxide dismutase and catalase mediated by cell-penetrating peptide, PEP-1, to protect myocardium from ischemia-reperfusion injury

Guang-Qing Huang, Jia-Ning Wang, Jun-Ming Tang, Lei Zhang, Fei Zheng, Jian-Ye Yang, Ling-Yun Guo, Xia Kong, Yong-Zhang Huang, Yong Liu, Shi-You Chen

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples

Catherine P Riley, Xiang Zhang, Harikrishna Nakshatri, Bryan Schneider, Fred E Regnier, Jiri Adamec, Charles Buck

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Ekua W Brenu, Mieke L van Driel, Don R Staines, Kevin J Ashton, Sandra B Ramos, James Keane, Nancy G Klimas, Sonya M Marshall-Gradisnik

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Rapid label-free identification of mixed bacterial infections by surface plasmon resonance

Jue Wang, Yang Luo, Bo Zhang, Ming Chen, Junfu Huang, Kejun Zhang, Weiyin Gao, Weiling Fu, Tianlun Jiang, Pu Liao

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Methylation levels of the "long interspersed nucleotide element-1" repetitive sequences predict survival of melanoma patients

Luca Sigalotti, Elisabetta Fratta, Ettore Bidoli, Alessia Covre, Giulia Parisi, Francesca Colizzi, Sandra Coral, Samuele Massarut, John M Kirkwood, Michele Maio

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Induction of Th1Immune responses following laser ablation in a murine model of colorectal liver metastases

Wen Xu Lin, Theodora Fifis, Caterina Malcontenti-Wilson, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Linh Nguyen, Christopher Christophi

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Codon usage in vertebrates is associated with a low risk of acquiring nonsense mutations

Pirmin Schmid, Willy A Flegel

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Value of large scale expansion of tumor infiltrating lymphocytes in a compartmentalised gas-permeable bag: interests for adoptive immunotherapy

Thomas Zuliani, Julien David, Sylvain Bercegeay, Marie-Christine Pandolfino, Isabelle Rodde-Astier, Amir Khammari, Cécile Coissac, Bruno Delorme, Soraya Saïagh, Brigitte Dréno

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Ozone acting on human blood yields a hormetic dose-response relationship

Velio A Bocci, Iacopo Zanardi, Valter Travagli

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A predicted protein, KIAA0247, is a cell cycle modulator in colorectal cancer cells under 5-FU treatment

Chi-Jung Huang, Shung-Haur Yang, Shih-Ming Huang, Chih-Ming Lin, Chih-Cheng Chien, Yan-Chu Chen, Chia-Long Lee, Hao-Han Wu, Chun-Chao Chang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

No relationship between the distribution of mast cells and the survival of stage IIIB colon cancer patients

Qing Xia, Xiao-Jun Wu, Qiang Zhou, Jing-Zeng, Jing-Hui Hou, Zhi-Zhong Pan, Xiao-Shi Zhang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

Melissa G Lechner, Carolina Megiel, Sarah M Russell, Brigid Bingham, Nicholas Arger, Tammy Woo, Alan L Epstein

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Buffy coat specimens remain viable as a DNA source for highly multiplexed genome-wide genetic tests after long term storage

Josyf C Mychaleckyj, Emily A Farber, Jessica Chmielewski, Jamie Artale, Laney S Light, Donald W Bowden, Xuanlin Hou, Santica M Marcovina

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Trauma is danger

Paul F Hwang, Nancy Porterfield, Dylan Pannell, Thomas A Davis, Eric A Elster

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The impact of Metastasis Suppressor-1, MTSS1, on oesophageal squamous cell carcinoma and its clinical significance

Fei Xie, Lin Ye, Jinfeng Chen, Nan Wu, Zhiqian Zhang, Yue Yang, Lijian Zhang, Wen G Jiang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Protein kinase CK2α is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT-related genes

Jinjin Zou, Hesan Luo, Qin Zeng, Zhongyi Dong, Dehua Wu, Li Liu

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Comparative study of clinical grade human tolerogenic dendritic cells

M Naranjo-Gómez, D Raïch-Regué, C Oñate, L Grau-López, C Ramo-Tello, R Pujol-Borrell, E Martínez-Cáceres, Francesc E Borràs

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

CD4saurus Rex &HIVelociraptor vs. development of clinically useful immunological markers: a Jurassic tale of frozen evolution

Andrea De Maria, Andrea Cossarizza

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of response to chemotherapy

Chiara Arienti, Anna Tesei, Giorgio Maria Verdecchia, Massimo Framarini, Salvatore Virzì, Antonio Grassi, Emanuela Scarpi, Livia Turci, Rosella Silvestrini, Dino Amadori, Wainer Zoli

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Spectratyping analysis of the islet-reactive T cell repertoire in diabetic NOD Igμnull mice after polyclonal B cell reconstitution

Allen M Vong, Nazila Daneshjou, Patricia Y Norori, Huiming Sheng, Todd A Braciak, Eli E Sercarz, Claudia Raja Gabaglia

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients

Thomas K Kilvaer, Andrej Valkov, Sveinung W Sorbye, Eivind Smeland, Roy M Bremnes, Lill-Tove Busund, Tom Donnem

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication

Chiara Orlandi, Greta Forlani, Giovanna Tosi, Roberto S Accolla

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Phosphoproteomic analysis of apoptotic hematopoietic stem cells from hemoglobin E/β-thalassemia

Saranyoo Ponnikorn, Tasanee Panichakul, Kitima Sresanga, Chokdee Wongborisuth, Sittiruk Roytrakul, Suradej Hongeng, Sumalee Tungpradabkul

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines

Bani M Azari, Jonathan D Marmur, Moro O Salifu, Yigal H Ehrlich, Elizabeth Kornecki, Anna Babinska

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Bisphosphonate-associated osteonecrosis of the jaw is linked to suppressed TGFβ1-signaling and increased Galectin-3 expression: A histological study on biopsies

Falk Wehrhan, Peter Hyckel, Arndt Guentsch, Emeka Nkenke, Phillip Stockmann, Karl A Schlegel, Friedrich W Neukam, Kerstin Amann

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Periostin: a promising target of therapeutical intervention for prostate cancer

Chuanyu Sun, Xiaojun Zhao, Ke Xu, Jian Gong, Weiwei Liu, Weihong Ding, Yuancheng Gou, Guowei Xia, Qiang Ding

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Effects of transplantation with bone marrow-derived mesenchymal stem cells modified by Survivin on experimental stroke in rats

Nan Liu, Yixian Zhang, Lin Fan, Mingzhou Yuan, Houwei Du, Ronghua Cheng, Deshan Liu, Feifei Lin

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer

Binbin Chen, Manu O Platt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

High Chromosome Number in hematological cancer cell lines is a Negative Predictor of Response to the inhibition of Aurora B and C by GSK1070916

Christopher Moy, Catherine A Oleykowski, Ramona Plant, Joel Greshock, Junping Jing, Kurtis Bachman, Mary Ann Hardwicke, Richard Wooster, Yan Degenhardt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays

Hyun Ok Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin, Sungha Park

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation

Marco Lo Iacono, Valentina Monica, Silvia Saviozzi, Paolo Ceppi, Enrico Bracco, Mauro Papotti, Giorgio V Scagliotti

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A critical assessment for the value of markers to gate-out undesired events in HLA-peptide multimer staining protocols

Sebastian Attig, Leah Price, Sylvia Janetzki, Michael Kalos, Michael Pride, Lisa McNeil, Tim Clay, Jianda Yuan, Kunle Odunsi, Axel Hoos, Pedro Romero, Cedrik M Britten, the CRI-CIC Assay Working Group

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

Inma Castilla-Cortázar, María García-Fernández, Gloria Delgado, Juan E Puche, Inma Sierra, Rima Barhoum, Salvador González-Barón

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

Joanna D Holbrook, Joel S Parker, Kathleen T Gallagher, Wendy S Halsey, Ashley M Hughes, Victor J Weigman, Peter F Lebowitz, Rakesh Kumar

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration

Baoying Liu, Lai Wei, Catherine Meyerle, Jingsheng Tuo, H Nida Sen, Zhiyu Li, Sagarika Chakrabarty, Elvira Agron, Chi-Chao Chan, Michael L Klein, Emily Chew, Frederick Ferris, Robert B Nussenblatt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Autologous Transplantation of Adipose-Derived Mesenchymal Stem Cells Markedly Reduced Acute Ischemia-Reperfusion Lung Injury in a Rodent Model

Cheuk-Kwan Sun, Chia-Hung Yen, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Ying-Hsien Kao, Sarah Chua, Morgan Fu, Sheung-Fat Ko, Steve Leu, Hon-Kan Yip

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study

Liv Jonsson, Julia Bergman, Björn Nodin, Jonas Manjer, Fredrik Pontén, Mathias Uhlén, Karin Jirström

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Combination therapy: the next opportunity and challenge of medicine

Paolo A Ascierto, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Cytotoxic T lymphocyte responses against melanocytes and melanoma

Gwendolen Y Chang, Holbrook E Kohrt, Tor B Stuge, Erich J Schwartz, Jeffrey S Weber, Peter P Lee

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Summit on cell therapy for cancer: The importance of the interaction of multiple disciplines to advance clinical therapy

Cornelis JM Melief, John J O'Shea, David F Stroncek

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Introducing the neurosciences section of the journal of translational medicine

Luis F Alguacil

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Biobanking after robotic-assisted radical prostatectomy: a quality assessment of providing prostate tissue for RNA studies

Harveer Dev, David Rickman, Prasanna Sooriakumaran, Abhishek Srivastava, Sonal Grover, Robert Leung, Robert Kim, Naoki Kitabayashi, Raquel Esqueva, Kyung Park, Jessica Padilla, Mark Rubin, Ashutosh Tewari

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Liver mitochondrial dysfunction is reverted by insulin-like growth factor II (IGF-II) in aging rats

Maria Garcia-Fernandez, Inma Sierra, Juan E Puche, Lucia Guerra, Inma Castilla-Cortazar

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma

Mikiko Takikita, Ran Xie, Joon-Yong Chung, Hanbyoul Cho, Kris Ylaya, Seung-Mo Hong, Christopher A Moskaluk, Stephen M Hewitt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease

Hayk Davtyan, Anahit Ghochikyan, Richard Cadagan, Dmitriy Zamarin, Irina Petrushina, Nina Movsesyan, Luis Martinez-Sobrido, Randy A Albrecht, Adolfo García-Sastre, Michael G Agadjanyan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice

Jin-Hong Shin, Brian Bostick, Yongping Yue, Roger Hajjar, Dongsheng Duan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Mechanism-related circulating proteins as biomarkers for clinical outcome in patients with unresectable hepatocellular carcinoma receiving sunitinib

Charles S Harmon, Samuel E DePrimo, Eric Raymond, Ann-Lii Cheng, Eveline Boucher, Jean-Yves Douillard, Ho Y Lim, Jun S Kim, Maria José Lechuga, Silvana Lanzalone, Xun Lin, Sandrine Faivre

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Electroporation increases antitumoral efficacy of the bcl-2 antisense G3139 and chemotherapy in a human melanoma xenograft

Enrico P Spugnini, Annamaria Biroccio, Roberta De Mori, Marco Scarsella, Carmen D'Angelo, Alfonso Baldi, Carlo Leonetti

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

Science that "knows" and science that "asks"

Pierre R Smeesters, Marie Deghorain, Andrew C Steer

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

Shaheen E Lakhan, Annette Kirchgessner

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes

Qunrui Ye, Maria Loisiou, Bruce L Levine, Megan M Suhoski, James L Riley, Carl H June, George Coukos, Daniel J Powell Jr

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Increased human defensine levels hint at an inflammatory etiology of bisphosphonate-associated osteonecrosis of the jaw: An immunohistological study

Philipp Stockmann, Falk Wehrhan, Stephan Schwarz-Furlan, Florian Stelzle, Susanne Trabert, Friedrich W Neukam, Emeka Nkenke

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Clinical translation section: accelerating the pace from bench to bedside

Lana E Kandalaft, George Coukos

01.12.2011 | Protocol | Ausgabe 1/2011 Open Access

Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I)

Felix C Popp, Barbara Fillenberg, Elke Eggenhofer, Philipp Renner, Johannes Dillmann, Volker Benseler, Andreas A Schnitzbauer, James Hutchinson, Robert Deans, Deborah Ladenheim, Cheryl A Graveen, Florian Zeman, Michael Koller, Martin J Hoogduijn, Edward K Geissler, Hans J Schlitt, Marc H Dahlke

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Glycyrrhizin as antiviral agent against Hepatitis C Virus

Usman A Ashfaq, Muhammad S Masoud, Zafar Nawaz, Sheikh Riazuddin

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Fuzzy obesity index (MAFOI) for obesity evaluation and bariatric surgery indication

Susana Abe Miyahira, João Luiz Moreira Coutinho de Azevedo, Ernesto Araújo

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Biomarkers in T cell therapy clinical trials

Michael Kalos

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas

Christoph Bergmann, Hagen S Bachmann, Agnes Bankfalvi, Ramin Lotfi, Carolin Pütter, Clarissa A Wild, Patrick J Schuler, Jens Greve, Thomas K Hoffmann, Stephan Lang, André Scherag, Götz F Lehnerdt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Combination immunotherapy and active-specific tumor cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer

Natasja K van den Engel, Dominik Rüttinger, Margareta Rusan, Robert Kammerer, Wolfgang Zimmermann, Rudolf A Hatz, Hauke Winter

01.12.2011 | Research | Ausgabe 1/2011 Open Access

An intronic SNP in the thyroid hormone receptor β gene is associated with pituitary cell-specific over-expression of a mutant thyroid hormone receptor β2 (R338W) in the index case of pituitary-selective resistance to thyroid hormone

Anna Teresa Alberobello, Valentina Congedo, Hong Liu, Craig Cochran, Monica C Skarulis, Douglas Forrest, Francesco S Celi

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

Aymen A Elfiky, Saadia A Aziz, Patricia J Conrad, Summar Siddiqui, Wolfgang Hackl, Michel Maira, Camp L Robert, Harriet M Kluger

01.12.2011 | Research | Ausgabe 1/2011 Open Access

CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances

Mirosław Andrusiewicz, Anna Szczerba, Maria Wołuń-Cholewa, Wojciech Warchoł, Ewa Nowak-Markwitz, Emilia Gąsiorowska, Krystyna Adamska, Anna Jankowska

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

Generation of high-titer viral preparations by concentration using successive rounds of ultracentrifugation

Christine V Ichim, Richard A Wells

01.12.2011 | Review | Ausgabe 1/2011 Open Access

An immunologic portrait of cancer

Maria Libera Ascierto, Valeria De Giorgi, Qiuzhen Liu, Davide Bedognetti, Tara L Spivey, Daniela Murtas, Lorenzo Uccellini, Ben D Ayotte, David F Stroncek, Lotfi Chouchane, Masoud H Manjili, Ena Wang, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer

Kirsten BJ Scholten, Annelies W Turksma, Janneke J Ruizendaal, Muriel van den Hende, Sjoerd H van der Burg, Mirjam HM Heemskerk, Chris JLM Meijer, Erik Hooijberg

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Cancer vaccines at an inflexion point: what next?

Adrian Bot, Mihail Obrocea, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Liver-spleen axis, insulin-like growth factor-(IGF)-I axis and fat mass in overweight/obese females

Silvia Savastano, Carolina Di Somma, Genoveffa Pizza, Annalba De Rosa, Valeria Nedi, Annalisa Rossi, Francesco Orio, Gaetano Lombardi, Annamaria Colao, Giovanni Tarantino

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke

Chun-Man Yuen, Cheuk-Kwan Sun, Yu-Chun Lin, Li-Teh Chang, Ying-Hsien Kao, Chia-Hung Yen, Yung-Lung Chen, Tzu-Hsien Tsai, Sarah Chua, Pei-Lin Shao, Steve Leu, Hon-Kan Yip

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

A whole blood monokine-based reporter assay provides a sensitive and robust measurement of the antigen-specific T cell response

Aron Chakera, Sophia C Bennett, Richard J Cornall

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Circulating CD133+CD34+ progenitor cells inversely correlate with soluble ICAM-1 in early ischemic stroke patients

Tanya Bogoslovsky, Maria Spatz, Aneeka Chaudhry, Dragan Maric, Marie Luby, Joseph Frank, Steven Warach

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Characteristics of Chinese patients with cough in primary care centre

Qunying Hong, Chunxue Bai, Xiangdong Wang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man

Andrew J Boyle, Yerem Yeghiazarians, Henry Shih, Joy Hwang, Jianqin Ye, Rich Sievers, Daiwei Zheng, Jath Palasubramaniam, Dharshan Palasubramaniam, Connie Karschimkus, Robert Whitbourn, Alicia Jenkins, Andrew M Wilson

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission

Barbara Beck, Daniela Dörfel, Felix S Lichtenegger, Christiane Geiger, Lysann Lindner, Martina Merk, Dolores J Schendel, Marion Subklewe

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Electrochemotherapy with cisplatin enhances local control after surgical ablation of fibrosarcoma in cats: an approach to improve the therapeutic index of highly toxic chemotherapy drugs

Enrico P Spugnini, Sylvie M Renaud, Sabrina Buglioni, Francesca Carocci, Emanuele Dragonetti, Raffaele Murace, Pierluigi Cardelli, Bruno Vincenzi, Alfonso Baldi, Gennaro Citro

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Cancer/Testis antigens as potential predictors of biochemical recurrence of prostate cancer following radical prostatectomy

Takumi Shiraishi, Naoki Terada, Yu Zeng, Takahito Suyama, Jun Luo, Bruce Trock, Prakash Kulkarni, Robert H Getzenberg

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Promoter methylation and downregulation of SLC22A18 are associated with the development and progression of human glioma

Sheng-Hua Chu, Dong-Fu Feng, Yan-Bin Ma, Hong Zhang, Zhi-An Zhu, Zhi-Qiang Li, Pu-Cha Jiang

01.12.2011 | Research | Ausgabe 1/2011 Open Access

An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma

Jian Pan, Yan-Fang Tao, Zhuan Zhou, Bang-rong Cao, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Jian Wang, Guo-Liang Lou, Zhen Li, Xing Feng, Jian Ni

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Vascular endothelial growth factor regulates melanoma cell adhesion and growth in the bone marrow microenvironment via tumor cyclooxygenase-2

María Valcárcel, Lorea Mendoza, José-Julio Hernández, Teresa Carrascal, Clarisa Salado, Olatz Crende, Fernando Vidal-Vanaclocha

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Genetic mutations in non-syndromic deafness patients of uyghur and han chinese ethnicities in xinjiang, China: a comparative study

Yu Chen, Mayila Tudi, Jie Sun, Chao He, Hong-li Lu, Qing Shang, Di Jiang, Pilidong Kuyaxi, Bin Hu, Hua Zhang

01.12.2011 | Review | Ausgabe 1/2011 Open Access

SITC/iSBTc Cancer Immunotherapy Biomarkers Resource Document: Online resources and useful tools - a compass in the land of biomarker discovery

Davide Bedognetti, James M Balwit, Ena Wang, Mary L Disis, Cedrik M Britten, Lucia G Delogu, Sara Tomei, Bernard A Fox, Thomas F Gajewski, Francesco M Marincola, Lisa H Butterfield

01.12.2011 | Research | Ausgabe 1/2011 Open Access

MicroRNA-134 as a potential plasma biomarker for the diagnosis of acute pulmonary embolism

Junjie Xiao, Zhi-Cheng Jing, Patrick T Ellinor, Dandan Liang, Hong Zhang, Ying Liu, Xiaoli Chen, Lei Pan, Robert Lyon, Yi Liu, Lu-Ying Peng, Xingqun Liang, Yunfu Sun, Laurentiu M Popescu, Gianluigi Condorelli, Yi-Han Chen

01.12.2011 | Research | Ausgabe 1/2011 Open Access

c-Jun NH2-terminal kinase activation is essential for up-regulation of LC3 during ceramide-induced autophagy in human nasopharyngeal carcinoma cells

Ting Sun, DanDan Li, LinLin Wang, LiangPing Xia, JianGuo Ma, Zhong Guan, GongKan Feng, XiaoFeng Zhu

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature

Antigone K Morou, Filippos Porichis, Elias Krambovitis, George Sourvinos, Demetrios A Spandidos, Alexandros Zafiropoulos

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer

Chantal Mengus, Clémentine Le Magnen, Emanuele Trella, Kawa Yousef, Lukas Bubendorf, Maurizio Provenzano, Alexander Bachmann, Michael Heberer, Giulio C Spagnoli, Stephen Wyler

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The role of amputation as an outcome measure in cellular therapy for critical limb ischemia: implications for clinical trial design

Eric Benoit, Thomas F O'Donnell Jr, Mark D Iafrati, Enrico Asher, Dennis F Bandyk, John W Hallett, Alan B Lumsden, Gregory J Pearl, Sean P Roddy, Krishnaswami Vijayaraghavan, Amit N Patel

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Proteomic detection of a large amount of SCGFα in the stroma of GISTs after imatinib therapy

Luca Da Riva, Fabio Bozzi, Piera Mondellini, Francesca Miccichè, Elena Fumagalli, Elena Vaghi, Eva Tarantino, Veronica Huber, Alessandro Gronchi, Elena Tamborini, Marco A Pierotti, Silvana Pilotti, Italia Bongarzone

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Replication efficiency of oncolytic vaccinia virus in cell cultures prognosticates the virulence and antitumor efficacy in mice

Nanhai G Chen, Yong A Yu, Qian Zhang, Aladar A Szalay

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma

Jiliang Qiu, Pinzhu Huang, Qian Liu, Jian Hong, Binkui Li, Canliang Lu, Li Wang, Jianping Wang, Yunfei Yuan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Distinct signatures of the immune responses in low risk versus high risk neuroblastoma

Madhu Gowda, Kamar Godder, Maciej Kmieciak, Andrea Worschech, Maria-Libera Ascierto, Ena Wang, Francesco M Marincola, Masoud H Manjili

01.12.2011 | Research | Ausgabe 1/2011 Open Access

EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma

Patrick J Schuler, Petra Boeckers, Rainer Engers, Edwin Boelke, Murat Bas, Jens Greve, Claudia A Dumitru, Goetz F Lehnerdt, Robert L Ferris, Pedro A Andrade Filho, Sven Brandau, Stephan Lang, Theresa L Whiteside, Thomas K Hoffmann

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

Multiplex serum biomarker assessments: technical and biostatistical issues

Lisa H Butterfield, Douglas M Potter, John M Kirkwood

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone

Joseph CK Leung, Loretta YY Chan, Sydney CW Tang, Man-Fai Lam, Chui-Wa Chow, Ai-Ing Lim, Kar-Neng Lai

01.12.2011 | Research | Ausgabe 1/2011 Open Access

mRNA expression levels and genetic status of genes involved in the EGFR and NF-κB pathways in metastatic non-small-cell lung cancer patients

Mariacarmela Santarpia, Ignacio Magri, Maria Sanchez-Ronco, Carlota Costa, Miguel Angel Molina-Vila, Ana Gimenez-Capitan, Jordi Bertran-Alamillo, Clara Mayo, Susana Benlloch, Santiago Viteri, Amaya Gasco, Nuria Mederos, Enric Carcereny, Miquel Taron, Rafael Rosell

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Extremely discrepant mutation spectrum of SLC26A4 between Chinese patients with isolated Mondini deformity and enlarged vestibular aqueduct

Shasha Huang, Dongyi Han, Yongyi Yuan, Guojian Wang, Dongyang Kang, Xin Zhang, Xiaofei Yan, Xiaoxiao Meng, Min Dong, Pu Dai

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Bacterial glucuronidase as general marker for oncolytic virotherapy or other biological therapies

Michael Hess, Jochen Stritzker, Barbara Härtl, Julia B Sturm, Ivaylo Gentschev, Aladar A Szalay

01.12.2011 | Protocol | Ausgabe 1/2011 Open Access

Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal

Argyris Tzouvelekis, George Koliakos, Paschalis Ntolios, Irene Baira, Evangelos Bouros, Anastasia Oikonomou, Athanassios Zissimopoulos, George Kolios, Despoina Kakagia, Vassilis Paspaliaris, Ioannis Kotsianidis, Marios Froudarakis, Demosthenes Bouros

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Molecular targets and oxidative stress biomarkers in hepatocellular carcinoma: an overview

Monica Marra, Ignazio M Sordelli, Angela Lombardi, Monica Lamberti, Luciano Tarantino, Aldo Giudice, Paola Stiuso, Alberto Abbruzzese, Rossella Sperlongano, Marina Accardo, Massimo Agresti, Michele Caraglia, Pasquale Sperlongano

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis

Tara L Spivey, Lorenzo Uccellini, Maria Libera Ascierto, Gabriele Zoppoli, Valeria De Giorgi, Lucia Gemma Delogu, Alyson M Engle, Jaime M Thomas, Ena Wang, Francesco M Marincola, Davide Bedognetti

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Combination therapy of renal cell carcinoma or breast cancer patients with dendritic cell vaccine and IL-2: results from a phase I/II trial

Soyoung Baek, Choung-Soo Kim, Sung-Bae Kim, Yong-man Kim, Seog-Woon Kwon, YongMan Kim, HyunSoo Kim, Hyunah Lee

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Tumour macrophages as potential targets of bisphosphonates

Thea L Rogers, Ingunn Holen

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Safety and feasibility of percutaneous retrograde coronary sinus delivery of autologous bone marrow mononuclear cell transplantation in patients with chronic refractory angina

Jorge Tuma, Roberto Fernández-Viña, Antonio Carrasco, Jorge Castillo, Carlos Cruz, Alvaro Carrillo, Jose Ercilla, Carlos Yarleque, Jaime Cunza, Timothy D Henry, Amit N Patel

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies

Sabine Tischer, Megan Basila, Britta Maecker-Kolhoff, Stephan Immenschuh, Mathias Oelke, Rainer Blasczyk, Britta Eiz-Vesper

01.12.2011 | Research | Ausgabe 1/2011 Open Access

High expression of HLA-E in colorectal carcinoma is associated with a favorable prognosis

Maria Benevolo, Marcella Mottolese, Elisa Tremante, Francesca Rollo, Maria Grazia Diodoro, Cristiana Ercolani, Isabella Sperduti, Elisa Lo Monaco, Maurizio Cosimelli, Patrizio Giacomini

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer

Satoshi Hayashi, Takumi Kumai, Yoshiya Matsuda, Naoko Aoki, Keisuke Sato, Shoji Kimura, Masahiro Kitada, Masatoshi Tateno, Esteban Celis, Hiroya Kobayashi

01.12.2011 | Protocol | Ausgabe 1/2011 Open Access

Chemotherapy-associated thromboembolic risk in cancer outpatients and effect of nadroparin thromboprophylaxis: results of a retrospective analysis of the PROTECHT study

Sandro Barni, Roberto Labianca, Giancarlo Agnelli, Erminio Bonizzoni, Melina Verso, Mario Mandalà, Matteo Brighenti, Fausto Petrelli, Carlo Bianchini, Tania Perrone, Giampietro Gasparini

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol

Wan-hua Yang, Hong-bin Gu, Bing Chen, Juan Li, Qiu-wei Fan, Yong-fang Yuan, Xiangdong Wang

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Stem cell treatment for patients with autoimmune disease by systemic infusion of culture-expanded autologous adipose tissue derived mesenchymal stem cells

Jeong Chan Ra, Sung Keun Kang, Il Seob Shin, Hyeong Geun Park, Sang Aun Joo, Jeong Geun Kim, Byeong-Cheol Kang, Yong Soon Lee, Ken Nakama, Min Piao, Bertram Sohl, Andras Kurtz

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism

Rena J Eudy, Vaishali Sahasrabudhe, Kevin Sweeney, Meera Tugnait, Amanda King-Ahmad, Kristen Near, Paula Loria, Mary Ellen Banker, David W Piotrowski, Carine M Boustany-Kari

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Correspondence between salivary proteomic pattern and clinical course in primary Sjögren syndrome and non-Hodgkin's lymphoma: a case report

Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesco Ferro, Sara Galimberti, Valentina Donati, Laura Bazzichi, Stefano Bombardieri, Antonio Lucacchini

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Distribution, characterization, and induction of CD8+ regulatory T cells and IL-17-producing CD8+ T cells in nasopharyngeal carcinoma

Jiang Li, Zhou-Feng Huang, Geng Xiong, Hao-Yuan Mo, Fang Qiu, Hai-Qiang Mai, Qiu-Yan Chen, Jia He, Shu-peng Chen, Li-Min Zheng, Chao-Nan Qian, Yi-Xin Zeng

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Long-term fenofibrate treatment impaired glucose-stimulated insulin secretion and up-regulated pancreatic NF-kappa B and iNOS expression in monosodium glutamate-induced obese rats: Is that a latent disadvantage?

Shuai-nan Liu, Quan Liu, Lin-yi Li, Yi Huan, Su-juan Sun, Zhu-fang Shen

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Huh-7 cell line as an alternative cultural model for the production of human like erythropoietin (EPO)

Humera Kausar, Sana Gull, Bushra Ijaz, Waqar Ahmad, Muhammad Tahir Sarwar, Zafar Iqbal, Zafar Nawaz, Sheikh Riazuddin, Sajida Hassan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Inhibition of HCV 3a genotype entry through Host CD81 and HCV E2 antibodies

Usman A Ashfaq, Muhammad Qasim, Muhammad Z Yousaf, Muhammad Tariq Awan, Shah Jahan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

MicroRNA modulation in complex regional pain syndrome

Irina A Orlova, Guillermo M Alexander, Rehman A Qureshi, Ahmet Sacan, Alessandro Graziano, James E Barrett, Robert J Schwartzman, Seena K Ajit

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas Ligand pathway

Veerauo V Konkankit, Won Kim, Richard C Koya, Ascia Eskin, Mai-Anh Dam, Stanley Nelson, Antoni Ribas, Linda M Liau, Robert M Prins

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Construction and characterisation of a recombinant fowlpox virus that expresses the human papilloma virus L1 protein

Carlo Zanotto, Eleana Pozzi, Sole Pacchioni, Massimiliano Bissa, Carlo De Giuli Morghen, Antonia Radaelli

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

How scientists use social media to communicate their research

Laura Van Eperen, Francesco M Marincola

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Gut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction

Shaheen E Lakhan, Annette Kirchgessner

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma

Omid Hamid, Henrik Schmidt, Aviram Nissan, Laura Ridolfi, Steinar Aamdal, Johan Hansson, Michele Guida, David M Hyams, Henry Gómez, Lars Bastholt, Scott D Chasalow, David Berman

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patients

Christoph Zenzmaier, Martin Heitz, Helmut Klocker, Marion Buck, Robert A Gardiner, Peter Berger

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy

Phuc V Pham, Nhan LC Phan, Nhung T Nguyen, Nhung H Truong, Thuy T Duong, Dong V Le, Kiet D Truong, Ngoc K Phan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas

Andrej Valkov, Thomas K Kilvaer, Sveinung W Sorbye, Tom Donnem, Eivind Smeland, Roy M Bremnes, Lill-Tove Busund

01.12.2011 | Research | Ausgabe 1/2011 Open Access

ATP synthase ecto-α-subunit: a novel therapeutic target for breast cancer

Jian Pan, Li-Chao Sun, Yan-Fang Tao, Zhuan Zhou, Xiao-Li Du, Liang Peng, Xing Feng, Jian Wang, Yi-Ping Li, Ling Liu, Shui-Yan Wu, Yan-Lan Zhang, Shao-Yan Hu, Wen-Li Zhao, Xue-Ming Zhu, Guo-Liang Lou, Jian Ni

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Molecular features of the complementarity determining region 3 motif of the T cell population and subsets in the blood of patients with chronic severe hepatitis B

Jiezuan Yang, Jianqin He, Haifeng Lu, Li Wei, Sujun Li, Baohong Wang, Hongyan Diao, Lanjuan Li

01.12.2011 | Research | Ausgabe 1/2011 Open Access

High dose intermittent sorafenib shows improved efficacy over conventional continuous dose in renal cell carcinoma

Xiaoen Wang, Liang Zhang, S Nahum Goldberg, Manoj Bhasin, Victoria Brown, David C Alsop, Sabina Signoretti, James W Mier, Michael B Atkins, Rupal S Bhatt

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Poly I: C-activated dendritic cells that were generated in CellGro for use in cancer immunotherapy trials

Jitka Fučíková, Daniela Rožková, Hana Ulčová, Vít Budinský, Klára Sochorová, Kateřina Pokorná, Jiřina Bartůňková, Radek Špíšek

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Granulocyte colony-stimulating factor affects the distribution and clonality of TRGV and TRDV repertoire of T cells and graft-versus-host disease

Li Xuan, Xiuli Wu, Yu Zhang, Zhiping Fan, Yiwen Ling, Fen Huang, Fuhua Zhang, Xiao Zhai, Qifa Liu

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

Anti-CTLA4 monoclonal antibodies: the past and the future in clinical application

Paolo A Ascierto, Francesco M Marincola, Antoni Ribas

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Expression of the Epigenetic factor BORIS (CTCFL) in the Human Genome

Rosalia de Necochea-Campion, Anahit Ghochikyan, Steven F Josephs, Shelly Zacharias, Erik Woods, Feridoun Karimi-Busheri, Doru T Alexandrescu, Chien-Shing Chen, Michael G Agadjanyan, Ewa Carrier

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease

Cailin M Wilke, Lin Wang, Shuang Wei, Ilona Kryczek, Emina Huang, John Kao, Yanwei Lin, Jingyuan Fang, Weiping Zou

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors

Enrico P Spugnini, Alfonso Baldi, Sabrina Buglioni, Francesca Carocci, Giulia Milesi de Bazzichini, Gianluca Betti, Ilaria Pantaleo, Francesco Menicagli, Gennaro Citro, Stefano Fais

01.12.2011 | Research | Ausgabe 1/2011 Open Access

A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions

Omer Raheem, Anna A Kulidjian, Christina Wu, Young B Jeong, Tomonori Yamaguchi, Kristen M Smith, Daniel Goff, Heather Leu, Sheldon R Morris, Nicholas A Cacalano, Koichi Masuda, Catriona HM Jamieson, Christopher J Kane, Christina AM Jamieson

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Personalized medicine: a patient - centered paradigm

Lotfi Chouchane, Ravinder Mamtani, Ashraf Dallol, Javaid I Sheikh

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Genomic sequencing in clinical trials

Karen K Mestan, Leonard Ilkhanoff, Samdeep Mouli, Simon Lin

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

The King is Dead, Long Live the King: Entering A New Era of Stem Cell Research and Clinical Development

Thomas Ichim, Neil H Riordan, David F Stroncek

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Methylation of miR-34a, miR-34b/c, miR-124-1 and miR-203 in Ph-negative myeloproliferative neoplasms

Chor Sang Chim, Thomas S Wan, Kwan Yeung Wong, Tsz Kin Fung, Hans G Drexler, Kit Fai Wong

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Optimizing parameters for clinical-scale production of high IL-12 secreting dendritic cells pulsed with oxidized whole tumor cell lysate

Cheryl L-L Chiang, Dawn A Maier, Lana E Kandalaft, Andrea L Brennan, Evripidis Lanitis, Qunrui Ye, Bruce L Levine, Brian J Czerniecki, Daniel J Powell Jr, George Coukos

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status

Bernice Lo, Austin DE Swafford, Kimberly A Shafer-Weaver, Lawrence F Jerome, Luba Rakhlin, Douglas R Mathern, Conor A Callahan, Ping Jiang, Lucy J Davison, Helen E Stevens, Carrie L Lucas, Jill White, Reid von Borstel, John A Todd, Michael J Lenardo

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Defining epitope coverage requirements for T cell-based HIV vaccines: Theoretical considerations and practical applications

Jeffrey R Currier, Merlin L Robb, Nelson L Michael, Mary A Marovich

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma

Wen-Ting Liao, Ling Guo, Yi Zhong, Yan-Heng Wu, Jun Li, Li-Bing Song

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Identification and manipulation of tumor associated macrophages in human cancers

Moniek Heusinkveld, Sjoerd H van der Burg

01.12.2011 | Research | Ausgabe 1/2011 Open Access

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

Hamid Akbarshahi, Jakob BF Axelsson, Katarzyna Said, Anders Malmström, Hans Fischer, Roland Andersson

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Calcium-sensing receptor and calcium kidney stones

Giuseppe Vezzoli, Annalisa Terranegra, Francesco Rainone, Teresa Arcidiacono, Mario Cozzolino, Andrea Aloia, Elena Dogliotti, Daniele Cusi, Laura Soldati

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Definition of the viral targets of protective HIV-1-specific T cell responses

Beatriz Mothe, Anuska Llano, Javier Ibarrondo, Marcus Daniels, Cristina Miranda, Jennifer Zamarreño, Vanessa Bach, Rosario Zuniga, Susana Pérez-Álvarez, Christoph T Berger, Maria C Puertas, Javier Martinez-Picado, Morgane Rolland, Marilu Farfan, James J Szinger, William H Hildebrand, Otto O Yang, Victor Sanchez-Merino, Chanson J Brumme, Zabrina L Brumme, David Heckerman, Todd M Allen, James I Mullins, Guadalupe Gómez, Philip J Goulder, Bruce D Walker, Jose M Gatell, Bonaventura Clotet, Bette T Korber, Jorge Sanchez, Christian Brander

01.12.2011 | Methodology | Ausgabe 1/2011 Open Access

Public health and valorization of genome-based technologies: a new model

Jonathan A Lal, Tobias Schulte in den Bäumen, Servaas A Morré, Angela Brand

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Clinical outcomes of active specific immunotherapy in advanced colorectal cancer and suspected minimal residual colorectal cancer: a meta-analysis and system review

Benqiang Rao, Minyan Han, Lei Wang, Xiaoyan Gao, Jun Huang, Meijin Huang, Huanliang Liu, Jianping Wang

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

Defining the critical hurdles in cancer immunotherapy

Bernard A Fox, Dolores J Schendel, Lisa H Butterfield, Steinar Aamdal, James P Allison, Paolo Antonio Ascierto, Michael B Atkins, Jirina Bartunkova, Lothar Bergmann, Neil Berinstein, Cristina C Bonorino, Ernest Borden, Jonathan L Bramson, Cedrik M Britten, Xuetao Cao, William E Carson, Alfred E Chang, Dainius Characiejus, A Raja Choudhury, George Coukos, Tanja de Gruijl, Robert O Dillman, Harry Dolstra, Glenn Dranoff, Lindy G Durrant, James H Finke, Jerome Galon, Jared A Gollob, Cécile Gouttefangeas, Fabio Grizzi, Michele Guida, Leif Håkansson, Kristen Hege, Ronald B Herberman, F Stephen Hodi, Axel Hoos, Christoph Huber, Patrick Hwu, Kohzoh Imai, Elizabeth M Jaffee, Sylvia Janetzki, Carl H June, Pawel Kalinski, Howard L Kaufman, Koji Kawakami, Yutaka Kawakami, Ulrich Keilholtz, Samir N Khleif, Rolf Kiessling, Beatrix Kotlan, Guido Kroemer, Rejean Lapointe, Hyam I Levitsky, Michael T Lotze, Cristina Maccalli, Michele Maio, Jens-Peter Marschner, Michael J Mastrangelo, Giuseppe Masucci, Ignacio Melero, Cornelius Melief, William J Murphy, Brad Nelson, Andrea Nicolini, Michael I Nishimura, Kunle Odunsi, Pamela S Ohashi, Jill O'Donnell-Tormey, Lloyd J Old, Christian Ottensmeier, Michael Papamichail, Giorgio Parmiani, Graham Pawelec, Enrico Proietti, Shukui Qin, Robert Rees, Antoni Ribas, Ruggero Ridolfi, Gerd Ritter, Licia Rivoltini, Pedro J Romero, Mohamed L Salem, Rik J Scheper, Barbara Seliger, Padmanee Sharma, Hiroshi Shiku, Harpreet Singh-Jasuja, Wenru Song, Per Thor Straten, Hideaki Tahara, Zhigang Tian, Sjoerd H van Der Burg, Paul von Hoegen, Ena Wang, Marij JP Welters, Hauke Winter, Tara Withington, Jedd D Wolchok, Weihua Xiao, Laurence Zitvogel, Heinz Zwierzina, Francesco M Marincola, Thomas F Gajewski, Jon M Wigginton, Mary L Disis

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Cathepsin B: a potential prognostic marker for inflammatory breast cancer

Mohamed A Nouh, Mona M Mohamed, Mohamed El-Shinawi, Mohamed A Shaalan, Dora Cavallo-Medved, Hussein M Khaled, Bonnie F Sloane

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins

Tonia Buonomo, Laura Carraresi, Mara Rossini, Rosanna Martinelli

01.12.2011 | Editorial | Ausgabe 1/2011 Open Access

Translational Medicine is developing in China: A new venue for collaboration

Xiangdong Wang, Ena Wang, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Frequency and spectrum of mitochondrial 12S rRNA variants in 440 Han Chinese hearing impaired pediatric subjects from two otology clinics

Zhisen Shen, Jing Zheng, Bobei Chen, Guanghua Peng, Ting Zhang, Shasha Gong, Yi Zhu, Chuqin Zhang, Ronghua Li, Li Yang, Jianjin Zhou, Ting Cai, Lihua Jin, Jianxin Lu, Min-Xin Guan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma

Mei Li, Rong-Zhen Luo, Jie-Wei Chen, Yun Cao, Jia-Bin Lu, Jie-Hua He, Qiu-Liang Wu, Mu-Yan Cai

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Prognostic Impact of MiR-155 in Non-Small Cell Lung Cancer Evaluated by in Situ Hybridization

Tom Donnem, Katrine Eklo, Thomas Berg, Sveinung W Sorbye, Kenneth Lonvik, Samer Al-Saad, Khalid Al-Shibli, Sigve Andersen, Helge Stenvold, Roy M Bremnes, Lill-Tove Busund

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit

Gaetano Santulli, Maria Felicia Basilicata, Mariarosaria De Simone, Carmine Del Giudice, Antonio Anastasio, Daniela Sorriento, Michele Saviano, Annarita Del Gatto, Bruno Trimarco, Carlo Pedone, Laura Zaccaro, Guido Iaccarino

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent

Tomohisa Horibe, Masayuki Kohno, Mari Haramoto, Koji Ohara, Koji Kawakami

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages

Cecilia Lässer, Vesta Seyed Alikhani, Karin Ekström, Maria Eldh, Patricia Torregrosa Paredes, Apostolos Bossios, Margareta Sjöstrand, Susanne Gabrielsson, Jan Lötvall, Hadi Valadi

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Angiogenic properties of aged adipose derived mesenchymal stem cells after hypoxic conditioning

Anastasia Efimenko, Ekaterina Starostina, Natalia Kalinina, Alexandra Stolzing

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Myocardium-derived conditioned medium improves left ventricular function in rodent acute myocardial infarction

Steve Leu, Ying-Hsien Kao, Cheuk-Kwan Sun, Yu-Chun Lin, Tzu-Hsien Tsai, Li-Teh Chang, Sarah Chua, Kuo-Ho Yeh, Chiung-Jen Wu, Morgan Fu, Hon-Kan Yip

01.12.2011 | Commentary | Ausgabe 1/2011 Open Access

Hybrid approach of ventricular assist device and autologous bone marrow stem cells implantation in end-stage ischemic heart failure enhances myocardial reperfusion

Kyriakos Anastasiadis, Polychronis Antonitsis, Helena Argiriadou, Georgios Koliakos, Argyrios Doumas, Andre Khayat, Christos Papakonstantinou, Stephen Westaby

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Etiopathology of chronic tubular, glomerular and renovascular nephropathies: Clinical implications

José M López-Novoa, Ana B Rodríguez-Peña, Alberto Ortiz, Carlos Martínez-Salgado, Francisco J López Hernández

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Replicative phenotyping adds value to genotypic resistance testing in heavily pre-treated HIV-infected individuals - the Swiss HIV Cohort Study

Jan Fehr, Tracy R Glass, Séverine Louvel, François Hamy, Hans H Hirsch, Viktor von Wyl, Jürg Böni, Sabine Yerly, Philippe Bürgisser, Matthias Cavassini, Christoph A Fux, Bernard Hirschel, Pietro Vernazza, Gladys Martinetti, Enos Bernasconi, Huldrych F Günthard, Manuel Battegay, Heiner C Bucher, Thomas Klimkait, the Swiss HIV Cohort Study

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Analysis of machine perfusion benefits in kidney grafts: a preclinical study

Nader Vaziri, Raphaël Thuillier, Frederic D Favreau, Michel Eugene, Serge Milin, Nicolas P Chatauret, Thierry Hauet, Benoit Barrou

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Medical education and research environment in Qatar: a new epoch for translational research in the Middle East

Lotfi Chouchane, Ravinder Mamtani, Mohammed H Al-Thani, Al-Anoud M Al-Thani, Marco Ameduri, Javaid I Sheikh

01.12.2011 | Review | Ausgabe 1/2011 Open Access

The iSBTc/SITC primer on tumor immunology and biological therapy of cancer: a summary of the 2010 program

James M Balwit, Patrick Hwu, Walter J Urba, Francesco M Marincola

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model

Christian Grimstein, Young-Kook Choi, Clive H Wasserfall, Minoru Satoh, Mark A Atkinson, Mark L Brantly, Martha Campbell-Thompson, Sihong Song

01.12.2011 | Erratum | Ausgabe 1/2011 Open Access

Erratum to Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression

Michaela Muth, Kais Hussein, Christoph Jacobi, Hans Kreipe, Oliver Bock

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

Thomas E Ichim, Boris Minev, Todd Braciak, Brandon Luna, Ron Hunninghake, Nina A Mikirova, James A Jackson, Michael J Gonzalez, Jorge R Miranda-Massari, Doru T Alexandrescu, Constantin A Dasanu, Vladimir Bogin, Janis Ancans, R Brian Stevens, Boris Markosian, James Koropatnick, Chien-Shing Chen, Neil H Riordan

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Shipping blood to a central laboratory in multicenter clinical trials: effect of ambient temperature on specimen temperature, and effects of temperature on mononuclear cell yield, viability and immunologic function

Walter C Olson, Mark E Smolkin, Erin M Farris, Robyn J Fink, Andrea R Czarkowski, Jonathan H Fink, Kimberly A Chianese-Bullock, Craig L Slingluff Jr

01.12.2011 | Research | Ausgabe 1/2011 Open Access

Glutamate carboxypeptidase activity in human skin biopsies as a pharmacodynamic marker for clinical studies

Camilo Rojas, Marigo Stathis, Michael Polydefkis, Michelle A Rudek, Ming Zhao, Gigi J Ebenezer, Barbara S Slusher

01.12.2011 | Review | Ausgabe 1/2011 Open Access

Risk factors in the development of stem cell therapy

Carla A Herberts, Marcel SG Kwa, Harm PH Hermsen

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