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Zeitschrift

Journal of Translational Medicine

Journal of Translational Medicine 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 371 Artikel )

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparison of membrane affinity-based method with size-exclusion chromatography for isolation of exosome-like vesicles from human plasma

Ruzena Stranska, Laurens Gysbrechts, Jens Wouters, Pieter Vermeersch, Katarzyna Bloch, Daan Dierickx, Graciela Andrei, Robert Snoeck

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Placental hypoxia-regulating network in relation to birth weight and ponderal index: the ENVIRONAGE Birth Cohort Study

Karen Vrijens, Maria Tsamou, Narjes Madhloum, Wilfried Gyselaers, Tim S. Nawrot

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Gamma-delta (γδ) T cells: friend or foe in cancer development?

Yijing Zhao, Chao Niu, Jiuwei Cui

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Accuracy of four mononucleotide-repeat markers for the identification of DNA mismatch-repair deficiency in solid tumors

Yuko Takehara, Takeshi Nagasaka, Akihiro Nyuya, Tomoko Haruma, Junko Haraga, Yoshiko Mori, Keiichiro Nakamura, Toshiyoshi Fujiwara, C. Richard Boland, Ajay Goel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial hypercholesterolemia

Lucía Baila-Rueda, Itziar Lamiquiz-Moneo, Estíbaliz Jarauta, Rocío Mateo-Gallego, Sofía Perez-Calahorra, Victoria Marco-Benedí, Ana M. Bea, Ana Cenarro, Fernando Civeira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway

Linan Zhu, Xudong Zhang, Xiaorui Fu, Zhaoming Li, Zhenchang Sun, Jingjing Wu, Xinhua Wang, Feng Wang, Xiangke Li, Songtao Niu, Mengjie Ding, Zhenzhen Yang, Wanqiu Yang, Meifeng Yin, Lei Zhang, Mingzhi Zhang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Effects of surgery and anesthetic choice on immunosuppression and cancer recurrence

Ryungsa Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer

Zhen-Fei Zhang, Han-Rong Zhang, Qing-Yan Zhang, Shu-Yu Lai, Yu-Zhen Feng, Yi Zhou, Si-Rong Zheng, Rong Shi, Jue-Yu Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of the replacement of dietary vegetable oils with a low dose of extravirgin olive oil in the Mediterranean Diet on cognitive functions in the elderly

Elisa Mazza, Antonietta Fava, Yvelise Ferro, Stefania Rotundo, Stefano Romeo, Domenico Bosco, Arturo Pujia, Tiziana Montalcini

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparative salivary proteomics analysis of children with and without dental caries using the iTRAQ/MRM approach

Kun Wang, Yufei Wang, Xiuqing Wang, Qian Ren, Sili Han, Longjiang Ding, Zhongcheng Li, Xuedong Zhou, Wei Li, Linglin Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The prognostic value of preoperative prognostic nutritional index in patients with hypopharyngeal squamous cell carcinoma: a retrospective study

Lu-Lu Ye, Ronald Wihal Oei, Fang-Fang Kong, Cheng-Run Du, Rui-Ping Zhai, Qing-Hai Ji, Chao-Su Hu, Hong-Mei Ying

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Enhanced clinical-scale manufacturing of TCR transduced T-cells using closed culture system modules

Jianjian Jin, Nikolaos Gkitsas, Vicki S. Fellowes, Jiaqiang Ren, Steven A. Feldman, Christian S. Hinrichs, David F. Stroncek, Steven L. Highfill

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Chronic diseases, inflammation, and spices: how are they linked?

Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti, Bharat B. Aggarwal

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Establishment and genomic characterizations of patient-derived esophageal squamous cell carcinoma xenograft models using biopsies for treatment optimization

Jianling Zou, Ying Liu, Jingyuan Wang, Zhentao Liu, Zhihao Lu, Zuhua Chen, Zhongwu Li, Bin Dong, Wenwen Huang, Yanyan Li, Jing Gao, Lin Shen

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Toolbox for Research, or how to facilitate a central data management in small-scale research projects

Martin Bialke, Henriette Rau, Oliver C. Thamm, Ronny Schuldt, Peter Penndorf, Arne Blumentritt, Robert Gött, Jens Piegsa, Thomas Bahls, Wolfgang Hoffmann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Voltammetric analysis for fast and inexpensive diagnosis of urinary tract infection: a diagnostic study

Diana Lelli, Claudio Pedone, Pamela Alemanno, Alessandra Bertini, Claudia Di Gioia, Sara Fazzina, Giorgio Pennazza, Marco Santonico, Simone Grasso, Alessandro Zompanti, Silvia Angeletti, Raffaele Antonelli Incalzi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Chromosome conformation signatures define predictive markers of inadequate response to methotrexate in early rheumatoid arthritis

Claudio Carini, Ewan Hunter, Aroul S. Ramadass, Jayne Green, Alexandre Akoulitchev, Iain B. McInnes, Carl S. Goodyear, Scottish Early Rheumatoid Arthritis Inception cohort Investigators

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Myeloid-derived suppressor cells in transplantation: the dawn of cell therapy

Weitao Zhang, Jiawei Li, Guisheng Qi, Guowei Tu, Cheng Yang, Ming Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Investigation of genetic variation and lifestyle determinants in vitamin D levels in Arab individuals

Massimo Mezzavilla, Sara Tomei, Fadi Alkayal, Motasem Melhem, Maisa M. Ali, Monira Al-Arouj, Abdullah Bennakhi, Osama Alsmadi, Naser Elkum

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Improvement of severe myalgic encephalomyelitis/chronic fatigue syndrome symptoms following surgical treatment of cervical spinal stenosis

Peter C. Rowe, Colleen L. Marden, Scott Heinlein, Charles C. Edwards II

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Expression of the Hippo transducer TAZ in association with WNT pathway mutations impacts survival outcomes in advanced gastric cancer patients treated with first-line chemotherapy

Elisa Melucci, Beatrice Casini, Livia Ronchetti, Laura Pizzuti, Francesca Sperati, Matteo Pallocca, Francesca De Nicola, Frauke Goeman, Enzo Gallo, Carla Azzurra Amoreo, Domenico Sergi, Irene Terrenato, Patrizia Vici, Luigi Di Lauro, Maria Grazia Diodoro, Edoardo Pescarmona, Maddalena Barba, Marco Mazzotta, Marcella Mottolese, Maurizio Fanciulli, Gennaro Ciliberto, Ruggero De Maria, Simonetta Buglioni, Marcello Maugeri-Saccà

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report

Katja Sonntag, Hisayoshi Hashimoto, Matthias Eyrich, Moritz Menzel, Max Schubach, Dennis Döcker, Florian Battke, Carolina Courage, Helmut Lambertz, Rupert Handgretinger, Saskia Biskup, Karin Schilbach

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons

Amy Wallis, Michelle Ball, Henry Butt, Donald P. Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa-Kwee, Dorothy Bruck

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Hepcidin, an emerging and important player in brain iron homeostasis

Driton Vela

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Turning the tables on cytomegalovirus: targeting viral Fc receptors by CARs containing mutated CH2–CH3 IgG spacer domains

Julia Proff, Charlotte U. Brey, Armin Ensser, Wolfgang Holter, Manfred Lehner

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Facial nerve stimulation in normal pigs and healthy human volunteers: transitional development of a medical device for the emergency treatment of ischemic stroke

Olivia Sanchez, Andrea García, Fernando Castro-Prado, Miriam Perez, Rafael Lara-Estrada, Martin Ramirez-Meza, Montserrat Godinez, Michael L. Coco, Joaquín Azpiroz, Mark K. Borsody, Emilio Sacristán

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Academic medical centers as innovation ecosystems to address population –omics challenges in precision medicine

Patrick J. Silva, Valerie M. Schaibley, Kenneth S. Ramos

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Non-viral gene delivery systems for tissue repair and regeneration

Pan Wu, Haojiao Chen, Ronghua Jin, Tingting Weng, Jon Kee Ho, Chuangang You, Liping Zhang, Xingang Wang, Chunmao Han

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Double-negative (CD27−IgD−) B cells are expanded in NSCLC and inversely correlate with affinity-matured B cell populations

Sara M. Centuori, Cecil J. Gomes, Samuel S. Kim, Charles W. Putnam, Brandon T. Larsen, Linda L. Garland, David W. Mount, Jesse D. Martinez

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Immunomodulatory plasticity of mesenchymal stem cells: a potential key to successful solid organ transplantation

Urvashi Kaundal, Upma Bagai, Aruna Rakha

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Computational analysis identifies putative prognostic biomarkers of pathological scarring in skin wounds

Sridevi Nagaraja, Lin Chen, Luisa A. DiPietro, Jaques Reifman, Alexander Y. Mitrophanov

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases

Maria A. Pizzichetta, Daniela Massi, Mario Mandalà, Paola Queirolo, Ignazio Stanganelli, Vincenzo De Giorgi, Giovanni Ghigliotti, Stefano Cavicchini, Pietro Quaglino, Maria T. Corradin, Pietro Rubegni, Mauro Alaibac, Stefano Astorino, Fabrizio Ayala, Serena Magi, Laura Mazzoni, Maria Ausilia Manganoni, Renato Talamini, Diego Serraino, Giuseppe Palmieri, on behalf of the Italian Melanoma Intergroup (IMI)

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Network modules uncover mechanisms of skeletal muscle dysfunction in COPD patients

Ákos Tényi, Isaac Cano, Francesco Marabita, Narsis Kiani, Susana G. Kalko, Esther Barreiro, Pedro de Atauri, Marta Cascante, David Gomez-Cabrero, Josep Roca

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Telomere attrition in heart failure: a flow-FISH longitudinal analysis of circulating monocytes

Iris Teubel, Elena Elchinova, Santiago Roura, Marco A. Fernández, Carolina Gálvez-Montón, Pedro Moliner, Marta de Antonio, Josep Lupón, Antoni Bayés-Genís

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies

Nicola Principi, Giada Maria Di Pietro, Susanna Esposito

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model

Jin-Sil Park, JeongWon Choi, Ji Ye Kwon, Kyung-Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tumor-promoting properties of miR-8084 in breast cancer through enhancing proliferation, suppressing apoptosis and inducing epithelial–mesenchymal transition

Yujing Gao, Hongning Ma, Chanchan Gao, Ye Lv, XueHua Chen, Rongrong Xu, Miao Sun, Xinrui Liu, Xiaohong Lu, Xiuying Pei, Pu Li

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons

Amy Wallis, Michelle Ball, Henry Butt, Donald P. Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa‑Kwee, Dorothy Bruck

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

Alexander W. Eckert, Claudia Wickenhauser, Paul C. Salins, Matthias Kappler, Juergen Bukur, Barbara Seliger

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer

Honghao Yu, Weihu Long, Xuezeng Zhang, Kaixiang Xu, Jianxiong Guo, Heng Zhao, Honghui Li, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang, Hong-Jiang Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children

Yong Song, Hilda Higgins, Jing Guo, Katrina Harrison, En Nee Schultz, Belinda J. Hales, Eric K. Moses, Jack Goldblatt, Nicholas Pachter, Guicheng Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project

Fernando Estévez-López, Daniel Camiletti-Moirón, Virginia A. Aparicio, Víctor Segura-Jiménez, Inmaculada C. Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Pedro Acosta-Manzano, Rinie Geenen, Manuel Delgado-Fernández, Luis J. Martínez-González, Jonatan R. Ruiz, María J. Álvarez-Cubero

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of chronic fatigue syndrome with premature telomere attrition

Mangalathu S. Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S. Lin, Elizabeth R. Unger

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel DNA methylation panel accurately detects colorectal cancer independently of molecular pathway

Micaela Freitas, Fábio Ferreira, Sónia Carvalho, Fernanda Silva, Paula Lopes, Luís Antunes, Sofia Salta, Francisca Diniz, Lúcio Lara Santos, José Flávio Videira, Rui Henrique, Carmen Jerónimo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification and validation a TGF-β-associated long non-coding RNA of head and neck squamous cell carcinoma by bioinformatics method

Teng Huang, Wei Huang, Hong Lu, Bi-yun Zhang, Jun Ma, Di Zhao, Yi-jun Wang, Da-hai Yu, Xia He

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Apatinib exhibits anti-leukemia activity in preclinical models of acute lymphoblastic leukemia

Manman Deng, Jie Zha, Zhiwu Jiang, Xian Jia, Yuanfei Shi, Peng Li, Xiao Lei Chen, Zhihong Fang, Zhiqiang Du, Bing Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Distinct alterations of CD68+CD163+ M2-like macrophages and myeloid-derived suppressor cells in newly diagnosed primary immune thrombocytopenia with or without CR after high-dose dexamethasone treatment

Xia Shao, Boting Wu, Luya Cheng, Feng Li, Yanxia Zhan, Chanjuan Liu, Lili Ji, Zhihui Min, Yang Ke, Lihua Sun, Hao Chen, Yunfeng Cheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Safety, tolerability and efficacy of intra-articular Progenza in knee osteoarthritis: a randomized double-blind placebo-controlled single ascending dose study

D. Kuah, S. Sivell, T. Longworth, K. James, A. Guermazi, F. Cicuttini, Y. Wang, S. Craig, G. Comin, D. Robinson, J. Wilson

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma

Xiaobo Cai, Jun Li, Xiaodong Yuan, Jingbo Xiao, Steven Dooley, Xinjian Wan, Honglei Weng, Lungen Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Physiological and molecular effects of interleukin-18 administration on the mouse kidney

Kyosuke Yamanishi, Keiichiro Mukai, Takuya Hashimoto, Kaoru Ikubo, Keiji Nakasho, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Tetsu Hayakawa, Hiroshi Nojima, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Allogeneic mesenchymal stem cells as induction therapy are safe and feasible in renal allografts: pilot results of a multicenter randomized controlled trial

Qipeng Sun, Zhengyu Huang, Fei Han, Ming Zhao, Ronghua Cao, Daqiang Zhao, Liangqing Hong, Ning Na, Heng Li, Bin Miao, Jianmin Hu, Fanhang Meng, Yanwen Peng, Qiquan Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The role of atorvastatin in suppressing tumor growth of uterine fibroids

Zhaojun Shen, Saisai Li, Bo Sheng, Qi Shen, Lu-Zhe Sun, Haiyan Zhu, Xueqiong Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Study on the progression types of cancer in patients with breast cancer undergoing eribulin chemotherapy and tumor microenvironment

Shinichiro Kashiwagi, Gen Tsujio, Yuka Asano, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Low dose Naltrexone for induction of remission in inflammatory bowel disease patients

Mitchell R. K. L. Lie, Janine van der Giessen, Gwenny M. Fuhler, Alison de Lima, Maikel P. Peppelenbosch, Cokkie van der Ent, C. Janneke van der Woude

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

Erik Lindström, Biljana Rizoska, Karin Tunblad, Charlotte Edenius, Alison M. Bendele, Don Maul, Michael Larson, Neha Shah, Valerie Yoder Otto, Chris Jerome, Urszula Grabowska

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis

Neil H. Riordan, Isabela Morales, Giselle Fernández, Nicole Allen, Neal E. Fearnot, Michael E. Leckrone, Dedra Jones Markovich, Darla Mansfield, Dorita Avila, Amit N. Patel, Santosh Kesari, Jorge Paz Rodriguez

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome

Jill K. Badin, Ayeeshik Kole, Benjamin Stivers, Victor Progar, Anisha Pareddy, Mouhamad Alloosh, Michael Sturek

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of γ-secretase inhibitor on Th17 cell differentiation and function of mouse psoriasis-like skin inflammation

Lei Ma, Haibo Xue, Ruiqun Qi, Yanqin Wang, Libing Yuan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Deregulated microRNA and mRNA expression profiles in the peripheral blood of patients with Marfan syndrome

Masood Abu-Halima, Mustafa Kahraman, Dominic Henn, Tanja Rädle-Hurst, Andreas Keller, Hashim Abdul-Khaliq, Eckart Meese

01.12.2018 | Research | Ausgabe 1/2018 Open Access

T cell mediated immunity induced by the live-attenuated Shigella flexneri 2a vaccine candidate CVD 1208S in humans

Franklin R. Toapanta, Paula J. Bernal, Karen L. Kotloff, Myron M. Levine, Marcelo B. Sztein

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of the cellular components involved in de novo immune hepatitis: a quantitative immunohistochemical analysis

Elena Aguado-Domínguez, Lourdes Gómez, José Manuel Sousa, Miguel Ángel Gómez-Bravo, Antonio Núñez-Roldán, Isabel Aguilera

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells

George Inana, Christopher Murat, Weijun An, Xiang Yao, Ian R. Harris, Jing Cao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells

Tiziana Alberio, Greta Forlani, Marta Lualdi, Giovanna Tosi, Roberto S. Accolla, Mauro Fasano

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparison of human bone marrow stromal cells cultured in human platelet growth factors and fetal bovine serum

Jiaqiang Ren, Dawn Ward, Steven Chen, Katherine Tran, Ping Jin, Marianna Sabatino, Pamela G. Robey, David F. Stroncek

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma

Margareta Heby, Sebastian Lundgren, Björn Nodin, Jacob Elebro, Jakob Eberhard, Karin Jirström

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HNA-3a and HNA-3b antigens among 9 ethnic populations and the Han population in Southwest China

Guo-Jin Ou, Pin-Can Su, Hao Yu, Xin Ji, Fan Liu, Sheng-Lan Wang, Yu-Jie Kong, Ling Li, Jue Wang, Zhong Liu, Willy Albert Flegel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia

Qiu-Ling Ma, Jing-Han Wang, Min Yang, Huan-ping Wang, Jie Jin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen, Hung-Chen Chen, Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Intermittent PTH administration improves alveolar bone formation in type 1 diabetic rats with periodontitis

Ji-Hye Kim, Ae Ri Kim, Yun Hui Choi, Aeryun Kim, Yongsung Sohn, Gye-Hyeong Woo, Jeong-Heon Cha, Eun-Jung Bak, Yun-Jung Yoo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Oral Escherichia coli expressing IL-35 meliorates experimental colitis in mice

Baoren Zhang, Yi Liu, Xu Lan, Xiaoxi Xu, Xiaoning Zhang, Xiang Li, Yiming Zhao, Guang Li, Caigan Du, Shanzheng Lu, Hao Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Bushenhuoxue formula attenuates cartilage degeneration in an osteoarthritic mouse model through TGF-β/MMP13 signaling

Ping-er Wang, Lei Zhang, Jun Ying, Xing Jin, Cheng Luo, Shibing Xu, Rui Dong, Luwei Xiao, Peijian Tong, Hongting Jin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Improving cancer detection through combinations of cancer and immune biomarkers: a modelling approach

Raluca Eftimie, Esraa Hassanein

01.12.2018 | Research | Ausgabe 1/2018 Open Access

OX40L induces helper T cell differentiation during cell immunity of asthma through PI3K/AKT and P38 MAPK signaling pathway

Li Huang, Meijuan Wang, Yongdong Yan, Wenjing Gu, Xinxing Zhang, Jiahong Tan, Huiming Sun, Wei Ji, Zhengrong Chen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The influence of diet on anti-cancer immune responsiveness

Laura Soldati, Laura Di Renzo, Emilio Jirillo, Paolo A. Ascierto, Francesco M. Marincola, Antonino De Lorenzo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of adiponectin gene variants with idiopathic recurrent miscarriage according to obesity status: a case–control study

Maryam Dendana, Wael Bahia, Ramzi R. Finan, Mariam Al-Mutawa, Wassim Y. Almawi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α2AR/PI3K/Akt pathway

Juanjuan Li, Qian Chen, Xinhai He, Azeem Alam, Jiaolin Ning, Bin Yi, Kaizhi Lu, Jianteng Gu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

YM155 decreases radiation-induced invasion and reverses epithelial–mesenchymal transition by targeting STAT3 in glioblastoma

Xin Zhang, Xuehai Wang, Ran Xu, Jianxiong Ji, Yangyang Xu, Mingzhi Han, Yuzhen Wei, Bin Huang, Anjing Chen, Qing Zhang, Wenjie Li, Jian Wang, Xingang Li, Chen Qiu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HLA alleles modulate EBV viral load in multiple sclerosis

Simone Agostini, Roberta Mancuso, Franca R. Guerini, Sandra D’Alfonso, Cristina Agliardi, Ambra Hernis, Milena Zanzottera, Nadia Barizzone, Maurizio A. Leone, Domenico Caputo, Marco Rovaris, Mario Clerici

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Distinctive features of immunostaining and mutational load in primary pulmonary enteric adenocarcinoma: implications for differential diagnosis and immunotherapy

Ming Chen, Pu Liu, Feifei Yan, Suzhen Xu, Qi Jiang, Jingying Pan, Mengye He, Peng Shen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors

Michael F. Gowen, Keith M. Giles, Danny Simpson, Jeremy Tchack, Hua Zhou, Una Moran, Zarmeena Dawood, Anna C. Pavlick, Shaohui Hu, Melissa A. Wilson, Hua Zhong, Michelle Krogsgaard, Tomas Kirchhoff, Iman Osman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association between serum S100A9 levels and liver necroinflammation in chronic hepatitis B

Rui Wu, Yuhong Zhang, Yu Xiang, Yishu Tang, Fang Cui, Ju Cao, Lan Zhou, Yan You, Liang Duan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Adolescent mental health education InSciEd Out: a case study of an alternative middle school population

Joanna Yang, Roberto Lopez Cervera, Susannah J. Tye, Stephen C. Ekker, Chris Pierret

01.12.2018 | Research | Ausgabe 1/2018 Open Access

An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis

Xiao-Juan Jiang, Dragos Cretoiu, Zong-Ji Shen, Xiao-Jun Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Use of the tumor-infiltrating CD8 to FOXP3 lymphocyte ratio in predicting treatment responses to combination therapy with pertuzumab, trastuzumab, and docetaxel for advanced HER2-positive breast cancer

Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prediction of treatment responses to neoadjuvant chemotherapy in triple-negative breast cancer by analysis of immune checkpoint protein expression

Yuka Asano, Shinichiro Kashiwagi, Wataru Goto, Koji Takada, Katsuyuki Takahashi, Tamami Morisaki, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Masahiko Ohsawa, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Review | Ausgabe 1/2018 Open Access

CD109 and squamous cell carcinoma

Ruixia Qi, Fengyun Dong, Qiang Liu, Yoshiki Murakumo, Ju Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Stromal TRIM28-associated signaling pathway modulation within the colorectal cancer microenvironment

Seán Fitzgerald, Virginia Espina, Lance Liotta, Katherine M. Sheehan, Anthony O’Grady, Robert Cummins, Richard O’Kennedy, Elaine W. Kay, Gregor S. Kijanka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML)

Ke-Wei Zhu, Peng Chen, Dao-Yu Zhang, Han Yan, Han Liu, Li-Na Cen, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Xiao-Ping Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Urinary miR-196a predicts disease progression in patients with chronic kidney disease

Changming Zhang, Shaoshan Liang, Shuiqin Cheng, Wei Li, Xia Wang, Chunxia Zheng, Caihong Zeng, Shaolin Shi, Lu Xie, Ke Zen, Zhihong Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention

Larisa H. Cavallari, Francesco Franchi, Fabiana Rollini, Latonya Been, Andrea Rivas, Malhar Agarwal, D. Max Smith, Kimberly Newsom, Yan Gong, Amanda R. Elsey, Petr Starostik, Julie A. Johnson, Dominick J. Angiolillo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Simultaneous VENTANA IHC and RT-PCR testing of ALK status in Chinese non-small cell lung cancer patients and response to crizotinib

Chun-wei Xu, Wen-xian Wang, Yan-ping Chen, Yu Chen, Wei Liu, Li-hua Zhong, Fang-fang Chen, Wu Zhuang, Zheng-bo Song, Xiao-hui Chen, Yun-jian Huang, Yan-fang Guan, Xin Yi, Tang-feng Lv, Wei-feng Zhu, Jian-ping Lu, Xiao-jiang Wang, Yi Shi, Xian-dong Lin, Gang Chen, Yong Song

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sex and interleukin-6 are prognostic factors for autoimmune toxicity following treatment with anti-CTLA4 blockade

Sara Valpione, Sandro Pasquali, Luca Giovanni Campana, Luisa Piccin, Simone Mocellin, Jacopo Pigozzo, Vanna Chiarion-Sileni

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis

Yoshinobu Ikeno, Satoru Seo, Keiko Iwaisako, Tomoaki Yoh, Yuji Nakamoto, Hiroaki Fuji, Kojiro Taura, Hideaki Okajima, Toshimi Kaido, Shimon Sakaguchi, Shinji Uemoto

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Cisplatin based therapy: the role of the mitogen activated protein kinase signaling pathway

Iman W. Achkar, Nabeel Abdulrahman, Hend Al-Sulaiti, Jensa Mariam Joseph, Shahab Uddin, Fatima Mraiche

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Weighting of orthostatic intolerance time measurements with standing difficulty score stratifies ME/CFS symptom severity and analyte detection

Alice M. Richardson, Don P. Lewis, Badia Kita, Helen Ludlow, Nigel P. Groome, Mark P. Hedger, David M. de Kretser, Brett A. Lidbury

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The physiological role of Motin family and its dysregulation in tumorigenesis

Tingting Huang, Yuhang Zhou, Jinglin Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project

Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima Moustaid-Moussa, Adeel A. Butt, Halima Bensmail

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The positive role of vitronectin in radiation induced lung toxicity: the in vitro and in vivo mechanism study

Tian-Le Shen, Mi-Na Liu, Qin Zhang, Wen Feng, Wen Yu, Xiao-Long Fu, Xu-Wei Cai

01.12.2018 | Meeting report | Ausgabe 1/2018 Open Access

The Great Debate at “Melanoma Bridge”, Napoli, December 2nd, 2017

Paolo A. Ascierto, Corrado Caracò, Jeffrey E. Gershenwald, Omid Hamid, Merrick Ross, Ryan J. Sullivan, Igor Puzanov

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?

C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia, N. Di Simone

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Recombinant mouse periostin ameliorates coronal sutures fusion in Twist1+/− mice

Shanshan Bai, Dong Li, Liang Xu, Huichuan Duan, Jie Yuan, Min Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease

Vasiliki Lygirou, Agnieszka Latosinska, Manousos Makridakis, William Mullen, Christian Delles, Joost P. Schanstra, Jerome Zoidakis, Burkert Pieske, Harald Mischak, Antonia Vlahou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Endoplasmic reticulum stress in perivascular adipose tissue promotes destabilization of atherosclerotic plaque by regulating GM-CSF paracrine

Ru Ying, Sheng-Wei Li, Jia-Yuan Chen, Hai-Feng Zhang, Ying Yang, Zhen-Jie Gu, Yang-Xin Chen, Jing-Feng Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Contribution of TLR4 signaling in intermittent hypoxia-mediated atherosclerosis progression

Xianqin Zeng, Rong Guo, Mei Dong, Julia Zheng, Huili Lin, Huixia Lu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Patient-derived xenograft models in musculoskeletal malignancies

Wan Lu, Tu Chao, Chen Ruiqi, Su Juan, Li Zhihong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading

Xin Chu, Qunyan Jin, Hui Chen, G. Craig Wood, Anthony Petrick, William Strodel, Jon Gabrielsen, Peter Benotti, Tooraj Mirshahi, David J. Carey, Christopher D. Still, Johanna K. DiStefano, Glenn S. Gerhard

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus

Julia Slotta-Huspenina, Enken Drecoll, Marcus Feith, Daniel Habermehl, Stephanie Combs, Wilko Weichert, Marcus Bettstetter, Karen Becker, Rupert Langer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel oncolytic chimeric orthopoxvirus causes regression of pancreatic cancer xenografts and exhibits abscopal effect at a single low dose

Michael P. O’Leary, Audrey H. Choi, Sang-In Kim, Shyambabu Chaurasiya, Jianming Lu, Anthony K. Park, Yanghee Woo, Susanne G. Warner, Yuman Fong, Nanhai G. Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cardiopulmonary bypass reduces myocardial oxidative stress, inflammation and increases c-kit+CD45− cell population in newborns

Johannes Petersen, Andrey Kazakov, Michael Böhm, Hans-Joachim Schäfers, Ulrich Laufs, Hashim Abdul-Khaliq

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The release of cardioprotective humoral factors after remote ischemic preconditioning in humans is age- and sex-dependent

André Heinen, Friederike Behmenburg, Aykut Aytulun, Maximilian Dierkes, Lea Zerbin, Wolfgang Kaisers, Maximilian Schaefer, Tanja Meyer-Treschan, Susanne Feit, Inge Bauer, Markus W. Hollmann, Ragnar Huhn

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Effects of mesenchymal stem cells on solid tumor metastasis in experimental cancer models: a systematic review and meta-analysis

Jing-Huan Li, Wen-Shuai Fan, Mi-Mi Wang, Yan-Hong Wang, Zheng-Gang Ren

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer

Zhuowei Gu, Yifeng He, Yue Zhang, Mo Chen, Keqi Song, Yuting Huang, Qing Li, Wen Di

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A validation study of crescents in predicting ESRD in patients with IgA nephropathy

Xiaoyan Zhang, Sufang Shi, Yan Ouyang, Meng Yang, Manman Shi, Xiaoxia Pan, Jicheng Lv, Zhaohui Wang, Hong Ren, Pingyan Shen, Weiming Wang, Hong Zhang, Jingyuan Xie, Nan Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Establishment and validation of a predictive nomogram model for non-small cell lung cancer patients with chronic hepatitis B viral infection

Shulin Chen, Yanzhen Lai, Zhengqiang He, Jianpei Li, Xia He, Rui Shen, Qiuying Ding, Hao Chen, Songguo Peng, Wanli Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury

Yu Gu, Fei Huang, Yanling Wang, Chaojin Chen, Shan Wu, Shaoli Zhou, Ziqing Hei, Dongdong Yuan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer

Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz, Zsuzsanna Varga

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Open innovation and external sources of innovation. An opportunity to fuel the R&D pipeline and enhance decision making?

Alexander Schuhmacher, Oliver Gassmann, Nigel McCracken, Markus Hinder

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Gastric cancer vaccines synthesized using a TLR7 agonist and their synergistic antitumor effects with 5-fluorouracil

Xiaodong Wang, Yu Liu, Yuwen Diao, Ningning Gao, Yanyan Wan, Jingjing Zhong, Huali Zheng, Zhulin Wang, Guangyi Jin

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The role of HIV Tat protein in HIV-related cardiovascular diseases

Yanan Jiang, Lu Chai, Moyondafoluwa Blessing Fasae, Yunlong Bai

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Gamma-delta (γδ) T cells: friend or foe in cancer development?

Yijing Zhao, Chao Niu, Jiuwei Cui

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Repair of articular cartilage defects with intra-articular injection of autologous rabbit synovial fluid-derived mesenchymal stem cells

Zhaofeng Jia, Qisong Liu, Yujie Liang, Xingfu Li, Xiao Xu, Kan Ouyang, Jianyi Xiong, Daping Wang, Li Duan

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Clinical-grade generation of peptide-stimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts

Regina Gary, Michael Aigner, Stephanie Moi, Stefanie Schaffer, Anja Gottmann, Stefanie Maas, Robert Zimmermann, Jürgen Zingsem, Julian Strobel, Andreas Mackensen, Josef Mautner, Andreas Moosmann, Armin Gerbitz

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

Erik Lindström, Biljana Rizoska, Ian Henderson, Ylva Terelius, Markus Jerling, Charlotte Edenius, Urszula Grabowska

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis

Ran Xue, Qinghua Meng, Jinling Dong, Juan Li, Qinwei Yao, Yueke Zhu, Hongwei Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comprehensive and integrative analysis identifies microRNA-106 as a novel non-invasive biomarker for detection of gastric cancer

Qiliang Peng, Yi Shen, Kaisu Lin, Li Zou, Yuntian Shen, Yaqun Zhu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: MicroRNA expression profiling for the prediction of resistance to neoadjuvant radiochemotherapy in squamous cell carcinoma of the esophagus

Julia Slotta-Huspenina, Enken Drecoll, Marcus Feith, Daniel Habermehl, Stephanie E. Combs, Wilko Weichert, Marcus Bettstetter, Karen Becker, Rupert Langer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Observational study of coagulation activation in early breast cancer: development of a prognostic model based on data from the real world setting

Chiara Mandoj, Laura Pizzuti, Domenico Sergi, Isabella Sperduti, Marco Mazzotta, Luigi Di Lauro, Antonella Amodio, Silvia Carpano, Anna Di Benedetto, Claudio Botti, Francesca Ferranti, Anna Antenucci, Maria Gabriella D’Alessandro, Paolo Marchetti, Silverio Tomao, Giuseppe Sanguineti, Antonio Giordano, Marcello Maugeri-Saccà, Gennaro Ciliberto, Laura Conti, Patrizia Vici, Maddalena Barba

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Evidence for a hyper-reductive redox in a sub-set of heart failure patients

Thiagarajan Sairam, Amit N. Patel, Meenu Subrahmanian, Rajendiran Gopalan, Steven M. Pogwizd, Sudha Ramalingam, Ramalingam Sankaran, Namakkal Soorapan Rajasekaran

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of micro-RNA expression profile related to recurrence in women with ESMO low-risk endometrial cancer

Tiphaine de Foucher, Maria Sbeih, Jenifer Uzan, Sofiane Bendifallah, Marine Lefevre, Nathalie Chabbert-Buffet, Selim Aractingi, Catherine Uzan, Issam Abd Alsalam, Rana Mitri, Romain H. Fontaine, Emile Daraï, Bassam Haddad, Céline Méhats, Marcos Ballester, Geoffroy Canlorbe, Cyril Touboul

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma

Chun Xu, Xian Lu, Wei Liu, Anxian Chen, Gang Meng, Hailin Zhang, Binghua Li, Yonghui Zhang, Junhua Wu, Jiwu Wei

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The homing of bone marrow stem cells is differentially activated in ischemic and valvular heart diseases and influenced by beta-blockers

Melissa Kristocheck, Lucinara D. Dias, Carine Ghem, Bruna Eibel, Renato A. K. Kalil, Melissa M. Markoski

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Biomarker microRNAs for prostate cancer metastasis: screened with a network vulnerability analysis model

Yuxin Lin, Feifei Chen, Li Shen, Xiaoyu Tang, Cui Du, Zhandong Sun, Huijie Ding, Jiajia Chen, Bairong Shen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dysregulation of miR-200s clusters as potential prognostic biomarkers in acute myeloid leukemia

Jing-dong Zhou, Liu-chao Zhang, Ting-juan Zhang, Yu Gu, De-hong Wu, Wei Zhang, Ji-chun Ma, Xiang-mei Wen, Hong Guo, Jiang Lin, Jun Qian

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Biobanks and scientists: supply and demand

Angelo Virgilio Paradiso, Maria Grazia Daidone, Vincenzo Canzonieri, Alfredo Zito

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Endothelial progenitor cells improve the therapeutic effect of mesenchymal stem cell sheets on irradiated bone defect repair in a rat model

Huan Liu, Yang Jiao, Wei Zhou, Shizhu Bai, Zhihong Feng, Yan Dong, Qian Liu, Xiaoke Feng, Yimin Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study

Yanan Jiang, Jimin Zhao, Yi Zhang, Ke Li, Tiepeng Li, Xinhuan Chen, Simin Zhao, Song Zhao, Kangdong Liu, Ziming Dong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Wedge-shaped microfluidic chip for circulating tumor cells isolation and its clinical significance in gastric cancer

Chaogang Yang, Nangang Zhang, Shuyi Wang, Dongdong Shi, Chunxiao Zhang, Kan Liu, Bin Xiong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nanoparticle delivery of grape seed-derived proanthocyanidins to airway epithelial cells dampens oxidative stress and inflammation

S. Castellani, A. Trapani, A. Spagnoletta, L. di Toma, T. Magrone, S. Di Gioia, D. Mandracchia, G. Trapani, E. Jirillo, M. Conese

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice

Yu-Min Liu, Wei Liu, Jun-Shuang Jia, Bang-Zhu Chen, Heng-Wei Chen, Yu Liu, Ya-Nan Bie, Peng Gu, Yan Sun, Dong Xiao, Wei-Wang Gu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A. Goldlust, Daniela A. Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A. Toms, Kevin O. Lillehei, Tom Mikkelsen, Tobias Walbert, Steven R. Abram, Andrew J. Brenner, Steven Brem, Matthew G. Ewend, Simon Khagi, Jana Portnow, Lyndon J. Kim, William G. Loudon, Reid C. Thompson, David E. Avigan, Karen L. Fink, Francois J. Geoffroy, Scott Lindhorst, Jose Lutzky, Andrew E. Sloan, Gabriele Schackert, Dietmar Krex, Hans-Jorg Meisel, Julian Wu, Raphael P. Davis, Christopher Duma, Arnold B. Etame, David Mathieu, Santosh Kesari, David Piccioni, Manfred Westphal, David S. Baskin, Pamela Z. New, Michel Lacroix, Sven-Axel May, Timothy J. Pluard, Victor Tse, Richard M. Green, John L. Villano, Michael Pearlman, Kevin Petrecca, Michael Schulder, Lynne P. Taylor, Anthony E. Maida, Robert M. Prins, Timothy F. Cloughesy, Paul Mulholland, Marnix L. Bosch

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acquired immunological imbalance after surgery with cardiopulmonary bypass due to epigenetic over-activation of PU.1/M-CSF

Krzysztof Laudanski, Mateusz Zawadka, Jacek Polosak, Jaymin Modi, Matthew DiMeglio, Jacob Gutsche, Wilson Y. Szeto, Monika Puzianowska-Kuznicka

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulatory γδ T cells induced by G-CSF participate in acute graft-versus-host disease regulation in G-CSF-mobilized allogeneic peripheral blood stem cell transplantation

Li Xuan, Xiuli Wu, Dan Qiu, Li Gao, Hui Liu, Zhiping Fan, Fen Huang, Zhenyi Jin, Jing Sun, Yangqiu Li, Qifa Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Distinct mutations with different inheritance mode caused similar retinal dystrophies in one family: a demonstration of the importance of genetic annotations in complicated pedigrees

Xue Chen, Xunlun Sheng, Yani Liu, Zili Li, Xiantao Sun, Chao Jiang, Rui Qi, Shiqin Yuan, Xuhui Wang, Ge Zhou, Yanyan Zhen, Ping Xie, Qinghuai Liu, Biao Yan, Chen Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

Yue Wang, Zong-ji Zheng, Yi-jie Jia, Yan-lin Yang, Yao-ming Xue

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Immunotherapeutic interventions of Triple Negative Breast Cancer

Zehuan Li, Yiran Qiu, Weiqi Lu, Ying Jiang, Jin Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Selective pharmacological inhibition of DDR1 prevents experimentally-induced glomerulonephritis in prevention and therapeutic regime

Solange Moll, Yukari Yasui, Ahmed Abed, Takeshi Murata, Hideaki Shimada, Akira Maeda, Naoshi Fukushima, Masakazu Kanamori, Sabine Uhles, Laura Badi, Thomas Cagarelli, Ivan Formentini, Faye Drawnel, Guy Georges, Tobias Bergauer, Rodolfo Gasser, R. Daniel Bonfil, Rafael Fridman, Hans Richter, Juergen Funk, Marcus J. Moeller, Christos Chatziantoniou, Marco Prunotto

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Expected advances in human fertility treatments and their likely translational consequences

Norbert Gleicher

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Granulin epithelin precursor promotes colorectal carcinogenesis by activating MARK/ERK pathway

Yi Pan, Siu Tim Cheung, Joanna Hung Man Tong, Ka Yee Tin, Wei Kang, Raymond Wai Ming Lung, Feng Wu, Hui Li, Simon Siu Man Ng, Tony Wing Chung Mak, Ka Fai To, Anthony Wing Hung Chan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework

Sujoy Ghosh Hajra, Careesa C. Liu, Xiaowei Song, Shaun D. Fickling, Teresa P. L. Cheung, Ryan C. N. D’Arcy

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Decrease of the DNA methylation levels of the ADRB3 gene in leukocytes is related with serum folate in eutrophic adults

Yohanna de Oliveira, Raquel Patrícia Ataíde Lima, Rafaella Cristhine Pordeus Luna, Mussara Gomes Cavalcanti Alves Monteiro, Cássia Surama Oliveira da Silva, Rayner Anderson Ferreira do Nascimento, Keylha Querino de Farias Lima, Ana Hermínia Andrade e Silva, Flávia Emília Leite de Lima Ferreira, Rodrigo Pinheiro de Toledo Vianna, Ronei Marcos de Moraes, Naila Francis Paulo de Oliveira, Aléssio Tony Cavalcanti de Almeida, Alexandre Sérgio Silva, Alcides da Silva Diniz, Maria José de Carvalho Costa, Maria da Conceição Rodrigues Gonçalves

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults

Christine M. D. Lingblom, Sangeeta Kowli, Nithya Swaminathan, Holden T. Maecker, Stacie L. Lambert

01.12.2018 | Research | Ausgabe 1/2018 Open Access

In silico identification of drug target pathways in breast cancer subtypes using pathway cross-talk inhibition

Claudia Cava, Gloria Bertoli, Isabella Castiglioni

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protein markers of dysfunctional HDL in scavenger receptor class B type I deficient mice

Jia Cao, Yanyong Xu, Feifei Li, Liang Shang, Daping Fan, Hong Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate

Alison O’Mahony, Markus R. John, Hannah Cho, Misato Hashizume, Ernest H. Choy

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A strategy for designing voriconazole dosage regimens to prevent invasive pulmonary aspergillosis based on a cellular pharmacokinetics/pharmacodynamics model

Taotao Wang, Tao Zhang, Ti Meng, Ying Li, Lu Chen, Qianting Yang, Haiyan Dong, Jin’e Lei, Limei Chen, Yalin Dong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Family specific genetic predisposition to breast cancer: results from Tunisian whole exome sequenced breast cancer cases

Yosr Hamdi, Maroua Boujemaa, Mariem Ben Rekaya, Cherif Ben Hamda, Najah Mighri, Houda El Benna, Nesrine Mejri, Soumaya Labidi, Nouha Daoud, Chokri Naouali, Olfa Messaoud, Mariem Chargui, Kais Ghedira, Mohamed Samir Boubaker, Ridha Mrad, Hamouda Boussen, Sonia Abdelhak, the PEC Consortium

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Microfibrillar-associated protein 4 variation in symptomatic peripheral artery disease

Line Ea Hemstra, Anders Schlosser, Jes Sanddal Lindholt, Grith L. Sorensen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2 G2019S -Parkinson’s disease

Diana Luz Juárez-Flores, Ingrid González-Casacuberta, Mario Ezquerra, María Bañó, Francesc Carmona-Pontaque, Marc Catalán-García, Mariona Guitart-Mampel, Juan José Rivero, Ester Tobias, Jose Cesar Milisenda, Eduard Tolosa, Maria Jose Marti, Ruben Fernández-Santiago, Francesc Cardellach, Constanza Morén, Glòria Garrabou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-1-3p that correlates with left ventricular function of HCM can serve as a potential target and differentiate HCM from DCM

Mengmeng Li, Xiao Chen, Liang Chen, Kai Chen, Jianye Zhou, Jiangping Song

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinicopathologic implication of microRNA-197 in diffuse large B cell lymphoma

Jeong Mi Yang, Ji-Young Jang, Yoon Kyung Jeon, Jin Ho Paik

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of a low risk population for parametrial invasion in patients with early-stage cervical cancer

Yohann Dabi, Claire Willecocq, Marcos Ballester, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Cyrille Huchon, Emile Daraï, Bassam Haddad, Cyril Touboul, For the Groupe de Recherche FRANCOGYN

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Knockdown of KLF5 suppresses hypoxia-induced resistance to cisplatin in NSCLC cells by regulating HIF-1α-dependent glycolysis through inactivation of the PI3K/Akt/mTOR pathway

Tianxiao Gong, Liuqing Cui, Haili Wang, Haoxun Wang, Na Han

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum IFN-γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis

Yi Yang, Xiao He, Rongseng Zhao, Wei Guo, Ming Zhu, Wei Xing, Dongpo Jiang, Chongyang Liu, Xiang Xu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prediction of hepatic necroinflammatory activity in patients with chronic hepatitis B by a simple noninvasive model

Fei-Fei Shen, Yan Wang, Yi-Fei Wang, Rui-Dan Zheng, Jian-Chun Xian, Jun-Ping Shi, Ying Qu, Yu-Wei Dong, Ming-Yi Xu, Lun-Gen Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

3D printing individualized heel cup for improving the self-reported pain of plantar fasciitis

Lan Li, Longfei Yang, Fei Yu, Jianping Shi, Liya Zhu, Xianfeng Yang, Huajian Teng, Xingsong Wang, Qing Jiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo

Siao-Syun Guan, Cheng-Tien Wu, Chen-Yuan Chiu, Tsai-Yueh Luo, Jeng-Yih Wu, Tse-Zung Liao, Shing-Hwa Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CHIP functions as an oncogene by promoting colorectal cancer metastasis via activation of MAPK and AKT signaling and suppression of E-cadherin

Jingjing Xu, Jun Zhou, Hanjue Dai, Fei Liu, Wenjing Li, Wenjuan Wang, Feng Guo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia

Sharon Wu, Yang Du, John Beckford, Houda Alachkar

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A prospective study on the changes and clinical significance of pre-operative and post-operative circulating tumor cells in resectable gastric cancer

Qiyue Zhang, Fei Shan, Ziyu Li, Jing Gao, Yilin Li, Lin Shen, Jiafu Ji, Ming Lu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients

Serena De Matteis, Chiara Molinari, Giulia Abbati, Tania Rossi, Roberta Napolitano, Martina Ghetti, Andrea Ghelli Luserna Di Rorà, Gerardo Musuraca, Alessandro Lucchesi, Gian Matteo Rigolin, Antonio Cuneo, Daniele Calistri, Pier Paolo Fattori, Massimiliano Bonafè, Giovanni Martinelli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of viral hepatitis and bipolar disorder: a nationwide population-based study

Lee-Won Chong, Chih-Chao Hsu, Chang-Yin Lee, Ruey-Hwang Chou, Cheng-Li Lin, Kuang-Hsi Chang, Yi-Chao Hsu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lapine periodontal ligament stem cells for musculoskeletal research in preclinical animal trials

H. Chopra, C. Liao, C. F. Zhang, E. H. N. Pow

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Triglyceride profiling in adipose tissues from obese insulin sensitive, insulin resistant and type 2 diabetes mellitus individuals

Haya Al-Sulaiti, Ilhame Diboun, Sameem Banu, Mohamed Al-Emadi, Parvaneh Amani, Thomas M. Harvey, Alex S. Dömling, Aishah Latiff, Mohamed A. Elrayess

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Efficacy and safety of the artificial pancreas in the paediatric population with type 1 diabetes

Susanna Esposito, Elisa Santi, Giulia Mancini, Francesco Rogari, Giorgia Tascini, Giada Toni, Alberto Argentiero, Maria Giulia Berioli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of anti-SF3B1 autoantibody as a diagnostic marker in patients with hepatocellular carcinoma

Hai-Min Hwang, Chang-Kyu Heo, Hye Jung Lee, Sang-Seob Kwak, Won-Hee Lim, Jong-Shin Yoo, Dae-Yuel Yu, Kook Jin Lim, Jeong-Yoon Kim, Eun-Wie Cho

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Obstacles to successful treatment of hepatitis C in uninsured patients from a minority population

Alexandra DeBose-Scarlett, Raymond Balise, Deukwoo Kwon, Susan Vadaparampil, Steven Xi Chen, Eugene R. Schiff, Gladys Patricia Ayala, Emmanuel Thomas

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Linda M. Liau, Keyoumars Ashkan, David D. Tran, Jian L. Campian, John E. Trusheim, Charles S. Cobbs, Jason A. Heth, Michael Salacz, Sarah Taylor, Stacy D. D’Andre, Fabio M. Iwamoto, Edward J. Dropcho, Yaron A. Moshel, Kevin A. Walter, Clement P. Pillainayagam, Robert Aiken, Rekha Chaudhary, Samuel A. Goldlust, Daniela A. Bota, Paul Duic, Jai Grewal, Heinrich Elinzano, Steven A. Toms, Kevin O. Lillehei, Tom Mikkelsen, Tobias Walbert, Steven R. Abram, Andrew J. Brenner, Steven Brem, Matthew G. Ewend, Simon Khagi, Jana Portnow, Lyndon J. Kim, William G. Loudon, Reid C. Thompson, David E. Avigan, Karen L. Fink, Francois J. Geoffroy, Scott Lindhorst, Jose Lutzky, Andrew E. Sloan, Gabriele Schackert, Dietmar Krex, Hans-Jorg Meisel, Julian Wu, Raphael P. Davis, Christopher Duma, Arnold B. Etame, David Mathieu, Santosh Kesari, David Piccioni, Manfred Westphal, David S. Baskin, Pamela Z. New, Michel Lacroix, Sven-Axel May, Timothy J. Pluard, Victor Tse, Richard M. Green, John L. Villano, Michael Pearlman, Kevin Petrecca, Michael Schulder, Lynne P. Taylor, Anthony E. Maida, Robert M. Prins, Timothy F. Cloughesy, Paul Mulholland, Marnix L. Bosch

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Limited utility of tissue micro-arrays in detecting intra-tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer

Pascale Kündig, Charlotte Giesen, Hartland Jackson, Bernd Bodenmiller, Bärbel Papassotirolopus, Sandra Nicole Freiberger, Catharine Aquino, Lennart Opitz, Zsuzsanna Varga

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Computer-aided prediction of antigen presenting cell modulators for designing peptide-based vaccine adjuvants

Gandharva Nagpal, Kumardeep Chaudhary, Piyush Agrawal, Gajendra P. S. Raghava

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Epstein–Barr virus- and cytomegalovirus-specific immune response in patients with brain cancer

Zhenjiang Liu, Thomas Poiret, Qingda Meng, Martin Rao, Anna von Landenberg, Esther Schoutrop, Davide Valentini, Ernest Dodoo, Inti Peredo-Harvey, Markus Maeurer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma

Xiqing Li, Zunlan Zhao, Shijiang Yi, Lei Ma, Ming Li, Mingyue Liu, Yaping Zhang, Guangzhi Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma

Janet Retseck, Alexis Nasr, Yan Lin, Huang Lin, Prateek Mendiratta, Lisa H. Butterfield, Ahmad A. Tarhini

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Genetic characterisation of molecular targets in carcinoma of unknown primary

B. Clynick, B. Dessauvagie, G. Sterrett, N. T. Harvey, R. J. N. Allcock, C. Saunders, W. Erber, K. Meehan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of the peripheral blood levels of circulating microRNAs with both recurrent miscarriage and the outcomes of embryo transfer in an in vitro fertilization process

Qian Yang, Wen-Wen Gu, Yan Gu, Na-Na Yan, Yan-Yan Mao, Xing-Xing Zhen, Jian-Mei Wang, Jing Yang, Hui-Juan Shi, Xuan Zhang, Jian Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel gene-expression-signature-based model for prediction of response to Tripterysium glycosides tablet for rheumatoid arthritis patients

Yanqiong Zhang, Hailong Wang, Xia Mao, Qiuyan Guo, Weijie Li, Xiaoyue Wang, Guangyao Li, Na Lin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves’ disease

Xinxin Chen, Fengjiao Huang, Yicheng Qi, Mengxi Zhou, Qinglei Yin, Ying Peng, Yulin Zhou, Guang Ning, Shu Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Gene expression pattern of TCR repertoire and alteration expression of IL-17A gene of γδ T cells in patients with acute myocardial infarction

Xiao-ming Chen, Tao Zhang, Dan Qiu, Jian-yi Feng, Zhen-yi Jin, Qiang Luo, Xin-yu Wang, Xiu-li Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Inhibition of endoplasmic-reticulum-stress-mediated autophagy enhances the effectiveness of chemotherapeutics on pancreatic cancer

Prakash C. Thakur, Jennifer L. Miller-Ocuin, Khanh Nguyen, Rina Matsuda, Aatur D. Singhi, Herbert J. Zeh, Nathan Bahary

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs

Andrew J. Pellatt, Lila E. Mullany, Jennifer S. Herrick, Lori C. Sakoda, Roger K. Wolff, Wade S. Samowitz, Martha L. Slattery

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The dimensionality of fatigue in Parkinson’s disease

Raymond Chong, Lauren Albor, Chandramohan Wakade, John Morgan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tanshinone IIA promotes the differentiation of bone marrow mesenchymal stem cells into neuronal-like cells in a spinal cord injury model

Xue-Mei Zhang, Jiao Ma, Yang Sun, Bing-Qian Yu, Zhuo-Min Jiao, Duo Wang, Mei-Yu Yu, Jin-Yue Li, Jin Fu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Detecting germline BAP1 mutations in patients with peritoneal mesothelioma: benefits to patient and family members

Muaiad Kittaneh, Charles Berkelhammer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparison of immunological characteristics between paired mismatch repair-proficient and -deficient colorectal cancer patients

Shou-Sheng Liu, Yuan-Zhong Yang, Chang Jiang, Qi Quan, Qian-Kun Xie, Xiao-Pai Wang, Wen-Zhuo He, Yu-Ming Rong, Ping Chen, Qiong Yang, Lin Yang, Bei Zhang, Xiao-Jun Xia, Peng-Fei Kong, Liang-Ping Xia

01.12.2018 | Protocol | Ausgabe 1/2018 Open Access

A Phase 1 trial of autologous monocytes stimulated ex vivo with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for intra-peritoneal administration in recurrent ovarian cancer

Daniel S. Green, Ana T. Nunes, Virginia David-Ocampo, Irene B. Ekwede, Nicole D. Houston, Steven L. Highfill, Hanh Khuu, David F. Stroncek, Seth M. Steinberg, Kathryn C. Zoon, Christina M. Annunziata

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens

Peng Chen, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Xiao-Ping Chen

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

PBMC fixation and processing for Chromium single-cell RNA sequencing

Jinguo Chen, Foo Cheung, Rongye Shi, Huizhi Zhou, Wenrui Lu, CHI Consortium

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Platelet storage induces accelerated desialylation of platelets and increases hepatic thrombopoietin production

Jooyoung Cho, Hyunkyung Kim, Jaewoo Song, June-Won Cheong, Jeong Won Shin, Woo Ick Yang, Hyun Ok Kim

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

A clarion call to the community of current and potential journal reviewers

Michael N. Liebman, Franco Marincola

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Resibufogenin suppresses colorectal cancer growth and metastasis through RIP3-mediated necroptosis

Qinrui Han, Ye Ma, Hao Wang, Yu Dai, Chunhui Chen, Yawei Liu, Linlin Jing, Xuegang Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection

Long Zheng, Jina Wang, Wenjun Gao, Chao Hu, Shuo Wang, Ruiming Rong, Yinlong Guo, Tongyu Zhu, Dong Zhu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Novel distance-progesterone-combined selection approach improves human sperm quality

Kun Li, Rui Li, Ya Ni, Peibei Sun, Ye Liu, Dan Zhang, Hefeng Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

In vivo evidence of ascorbate involvement in the generation of epigenetic DNA modifications in leukocytes from patients with colorectal carcinoma, benign adenoma and inflammatory bowel disease

Marta Starczak, Ewelina Zarakowska, Martyna Modrzejewska, Tomasz Dziaman, Anna Szpila, Kinga Linowiecka, Jolanta Guz, Justyna Szpotan, Maciej Gawronski, Anna Labejszo, Ariel Liebert, Zbigniew Banaszkiewicz, Maria Klopocka, Marek Foksinski, Daniel Gackowski, Ryszard Olinski

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of an early diagnostic biomarker of lung adenocarcinoma based on co-expression similarity and construction of a diagnostic model

Zhirui Fan, Wenhua Xue, Lifeng Li, Chaoqi Zhang, Jingli Lu, Yunkai Zhai, Zhenhe Suo, Jie Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Screening and identification of a six-cytokine biosignature for detecting TB infection and discriminating active from latent TB

Sen Wang, Yang Li, Yaojie Shen, Jing Wu, Yan Gao, Shu Zhang, Lingyun Shao, Jialin Jin, Ying Zhang, Wenhong Zhang

01.12.2018 | Meeting report | Ausgabe 1/2018 Open Access

Perspectives in melanoma: Meeting report from the Melanoma Bridge (30 November–2 December, 2017, Naples, Italy)

Paolo A. Ascierto, Igor Puzanov, Sanjiv S. Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A. Davies, Reinhard Dummer, Soldano Ferrone, Thomas F. Gajewski, Claus Garbe, Jason J. Luke, Francesco M. Marincola, Giuseppe Masucci, Janice M. Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A. Postow, Stephen P. Schoenberger, Ena Wang, Magdalena Thurin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Numerical simulation of patient-specific endovascular stenting and coiling for intracranial aneurysm surgical planning

Xiaochang Leng, Yang Wang, Jing Xu, Yeqing Jiang, Xiaolong Zhang, Jianping Xiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dexmedetomidine attenuates spinal cord ischemia–reperfusion injury through both anti-inflammation and anti-apoptosis mechanisms in rabbits

Zhixiang Sun, Tianyun Zhao, Shaojun Lv, Ying Gao, Joe Masters, Hao Weng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comprehensive identification of immune-associated biomarkers based on network and mRNA expression patterns in membranous glomerulonephritis

Chengwei Zhang, Lei Leng, Xiaoming Zhang, Yao Zhao, Zhaozheng Li

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

The new era of precision population health: insights for the All of Us Research Program and beyond

Courtney R. Lyles, Mitchell R. Lunn, Juno Obedin-Maliver, Kirsten Bibbins-Domingo

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Fibroblasts as a practical alternative to mesenchymal stem cells

Thomas E. Ichim, Pete O’Heeron, Santosh Kesari

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: long-term follow up of a multicenter randomized controlled clinical trial (phase I/II)

José María Lamo-Espinosa, Gonzalo Mora, Juan F. Blanco, Froilán Granero-Moltó, Jorge María Núñez-Córdoba, Silvia López-Elío, Enrique Andreu, Fermín Sánchez-Guijo, José Dámaso Aquerreta, José María Bondía, Andrés Valentí-Azcárate, María del Consuelo del Cañizo, Eva María Villarón, Juan Ramón Valentí-Nin, Felipe Prósper

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis

Marianne Engström, Kaja Eriksson, Linkiat Lee, Monika Hermansson, Anders Johansson, Anthony P. Nicholas, Natalija Gerasimcik, Karin Lundberg, Lars Klareskog, Anca Irinel Catrina, Tülay Yucel-Lindberg

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MRI of atherosclerosis and fatty liver disease in cholesterol fed rabbits

Erik Taylor, Nasi Huang, Jacob Bodde, Andrew Ellison, Ronald Killiany, Markus Michael Bachschmid, James Hamilton

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer

Jia Cheng, Huiqin Zhuo, Mao Xu, Linpei Wang, Hao Xu, Jigui Peng, Jingjing Hou, Lingyun Lin, Jianchun Cai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Improving knowledge on the activation of bone marrow fibroblasts in MGUS and MM disease through the automatic extraction of genes via a nonnegative matrix factorization approach on gene expression profiles

Angelina Boccarelli, Flavia Esposito, Mauro Coluccia, Maria Antonia Frassanito, Angelo Vacca, Nicoletta Del Buono

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The role of miR-29c/B7-H3 axis in children with allergic asthma

Xinxing Zhang, Xin Zhao, Huiming Sun, Yongdong Yan, Li Huang, Wenjin Gu, Wujun Jiang, Yuqing Wang, Canhong Zhu, Wei Ji, Chuangli Hao, Zhengrong Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?

Andrea Botticelli, Bruna Cerbelli, Luana Lionetto, Ilaria Zizzari, Massimiliano Salati, Annalinda Pisano, Mazzuca Federica, Maurizio Simmaco, Marianna Nuti, Paolo Marchetti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A circRNA–miRNA–mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma

Dan-dan Xiong, Yi-wu Dang, Peng Lin, Dong-yue Wen, Rong-quan He, Dian-zhong Luo, Zhen-bo Feng, Gang Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

HBV infection increases the risk of macular degeneration: the roles of HBx-mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation

Ruey-Hwang Chou, Chang-Yin Lee, Lee-Won Chong, Kuang-Hsi Chang, Cheng-Li Lin, Ke-Sin Yan, Chingfu Tsou, Yi-Chao Hsu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Comparing atmospheric and hypoxic cultured mesenchymal stem cell transcriptome: implication for stem cell therapies targeting intervertebral discs

C. Elabd, T. E. Ichim, K. Miller, A. Anneling, V. Grinstein, V. Vargas, F. J. Silva

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Protocol for serum exosomal miRNAs analysis in prostate cancer patients treated with radiotherapy

Bijaya Malla, Daniel M. Aebersold, Alan Dal Pra

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cord blood leptin and insulin levels in association with mitochondrial DNA content

Annette Vriens, Michelle Plusquin, Willy Baeyens, Liesbeth Bruckers, Elly Den Hond, Ilse Loots, Vera Nelen, Greet Schoeters, Bram G. Janssen, Tim S. Nawrot

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Lactobacillus salivarius reverse antibiotic-induced lung defense impairment in a ventilator model

Tzyy-Bin Tsay, Ming-Chieh Yang, Wan-Hsuan Chang, Pei-Hsuan Chen, Lee-Wei Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Enhanced effect of checkpoint inhibitors when given after or together with IMM-101: significant responses in four advanced melanoma patients with no additional major toxicity

Angus G. Dalgleish, Satvinder Mudan, Alberto Fusi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Urinary exosome miR-146a is a potential marker of albuminuria in essential hypertension

Javier Perez-Hernandez, Dolores Olivares, Maria J. Forner, Ana Ortega, Elena Solaz, Fernando Martinez, Felipe J. Chaves, Josep Redon, Raquel Cortes

01.12.2018 | Research | Ausgabe 1/2018 Open Access

YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis

Qing Wang, Hua Shen, Jie Min, Yang Gao, Kai Liu, Wang Xi, Jie Yang, Liang Yin, Jibin Xu, Jian Xiao, Zhinong Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Blood pressure components and incident cardiovascular disease and mortality events among Iranian adults with chronic kidney disease during over a decade long follow-up: a prospective cohort study

Ashkan Hashemi, Sormeh Nourbakhsh, Samaneh Asgari, Mohammadhassan Mirbolouk, Fereidoun Azizi, Farzad Hadaegh

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The expression signature of very long non-coding RNA in myalgic encephalomyelitis/chronic fatigue syndrome

Chin-An Yang, Sandra Bauer, Yu-Chen Ho, Franziska Sotzny, Jan-Gowth Chang, Carmen Scheibenbogen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NPM1 alternative transcripts are upregulated in acute myeloid and lymphoblastic leukemia and their expression level affects patient outcome

Luiza Handschuh, Pawel Wojciechowski, Maciej Kazmierczak, Malgorzata Marcinkowska-Swojak, Magdalena Luczak, Krzysztof Lewandowski, Mieczyslaw Komarnicki, Jacek Blazewicz, Marek Figlerowicz, Piotr Kozlowski

01.12.2018 | Research | Ausgabe 1/2018 Open Access

RIP3 dependent NLRP3 inflammasome activation is implicated in acute lung injury in mice

Jingxian Chen, Shuang Wang, Rong Fu, Mianjing Zhou, Tengyue Zhang, Wenxu Pan, Niansheng Yang, Yuefang Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical significance of hyaluronan levels and its pro-osteogenic effect on mesenchymal stromal cells in myelodysplastic syndromes

Cheng-Ming Fei, Juan Guo, You-Shan Zhao, Si-Da Zhao, Qing-Qing Zhen, Lei Shi, Xiao Li, Chun-Kang Chang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The changes of immunoglobulin G N-glycosylation in blood lipids and dyslipidaemia

Di Liu, Xi Chu, Hao Wang, Jing Dong, Si-Qi Ge, Zhong-Yao Zhao, Hong-Li Peng, Ming Sun, Li-Juan Wu, Man-Shu Song, Xiu-Hua Guo, Qun Meng, You-Xin Wang, Gordan Lauc, Wei Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Large-scale in silico identification of drugs exerting sex-specific effects in the heart

Changting Cui, Chuanbo Huang, Kejia Liu, Guoheng Xu, Jichun Yang, Yong Zhou, Yingmei Feng, Georgios Kararigas, Bin Geng, Qinghua Cui

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Cytokines induced killer cells produced in good manufacturing practices conditions: identification of the most advantageous and safest expansion method in terms of viability, cellular growth and identity

Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Laura Castello, Katia Mareschi, Giuseppe Pinnetta, Marco Leone, Alessandra Mandese, Ivana Ferrero, Giulia Mesiano, Franca Fagioli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Improved CD4 T cell profile in HIV-infected subjects on maraviroc-containing therapy is associated with better responsiveness to HBV vaccination

Inés Herrero-Fernández, Isaac Rosado-Sánchez, Miguel Genebat, Laura Tarancón-Díez, María Mar Rodríguez-Méndez, María Mar Pozo-Balado, Carmen Lozano, Ezequiel Ruiz-Mateos, Manuel Leal, Yolanda M. Pacheco

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Invasive non-typhoidal Salmonella in sickle cell disease in Africa: is increased gut permeability the missing link?

Seah H. Lim, Barbara A. Methé, Bettina M. Knoll, Alison Morris, Stephen K. Obaro

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Acute effects of different resistance training loads on cardiac autonomic modulation in hypertensive postmenopausal women

Arthur F. Vale, Juliana A. Carneiro, Paulo C. V. Jardim, Thiago V. Jardim, James Steele, James P. Fisher, Paulo Gentil

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Molecular analysis of inherited cardiomyopathy using next generation semiconductor sequencing technologies

Chaoxia Lu, Wei Wu, Fang Liu, Kunqi Yang, Jiacheng Li, Yaping Liu, Rongrong Wang, Nuo Si, Peng Gao, Yongtai Liu, Shuyang Zhang, Xue Zhang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Unleashing endogenous TNF-alpha as a cancer immunotherapeutic

Steven F. Josephs, Thomas E. Ichim, Stephen M. Prince, Santosh Kesari, Francesco M. Marincola, Anton Rolando Escobedo, Amir Jafri

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway

Mohamed A. Ghonim, Jeffrey Wang, Salome V. Ibba, Hanh H. Luu, Kusma Pyakurel, Ilyes Benslimane, Shaker Mousa, A. Hamid Boulares

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women

José O. Alemán, Nicholas A. Bokulich, Jonathan R. Swann, Jeanne M. Walker, Joel Correa De Rosa, Thomas Battaglia, Adele Costabile, Alexandros Pechlivanis, Yupu Liang, Jan L. Breslow, Martin J. Blaser, Peter R. Holt

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene

Christian Ramos-Peñafiel, Irma Olarte-Carrillo, Rafael Cerón-Maldonado, Etta Rozen-Fuller, Juan Julio Kassack-Ipiña, Guillermo Meléndez-Mier, Juan Collazo-Jaloma, Adolfo Martínez-Tovar

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Symptomatic anterior cruciate ligament tears treated with percutaneous injection of autologous bone marrow concentrate and platelet products: a non-controlled registry study

Christopher Centeno, Jason Markle, Ehren Dodson, Ian Stemper, Christopher Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Coexisting YAP expression and TP53 missense mutations delineates a molecular scenario unexpectedly associated with better survival outcomes in advanced gastric cancer

Matteo Pallocca, Frauke Goeman, Francesca De Nicola, Elisa Melucci, Francesca Sperati, Irene Terrenato, Laura Pizzuti, Beatrice Casini, Enzo Gallo, Carla Azzurra Amoreo, Patrizia Vici, Luigi Di Lauro, Simonetta Buglioni, Maria Grazia Diodoro, Edoardo Pescarmona, Marco Mazzotta, Maddalena Barba, Maurizio Fanciulli, Ruggero De Maria, Gennaro Ciliberto, Marcello Maugeri-Saccà

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unveiling metabolic remodeling in mucopolysaccharidosis type III through integrative metabolomics and pathway analysis

Abdellah Tebani, Lenaig Abily-Donval, Isabelle Schmitz-Afonso, Bénédicte Héron, Monique Piraud, Jérôme Ausseil, Farid Zerimech, Bruno Gonzalez, Stéphane Marret, Carlos Afonso, Soumeya Bekri

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CCR5del32 genotype in human enteroviral cardiomyopathy leads to spontaneous virus clearance and improved outcome compared to wildtype CCR5

Dirk Lassner, Christine S. Siegismund, Uwe Kühl, Maria Rohde, Andrea Stroux, Felicitas Escher, Heinz-Peter Schultheiss

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Multi-focused psychosocial residential rehabilitation interventions improve quality of life among cancer survivors: a community-based controlled trial

Xuefen Chen, Xiaohuan Gong, Changhong Shi, Li Sun, Zheng Tang, Zhengping Yuan, Jiwei Wang, Jinming Yu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circulating tumor cells criteria (CyCAR) versus standard RECIST criteria for treatment response assessment in metastatic colorectal cancer patients

Mayte Delgado-Ureña, Francisco G. Ortega, Diego de Miguel-Pérez, Alba Rodriguez-Martínez, Jose L. García-Puche, Hugh Ilyine, Jose A. Lorente, Jose Exposito-Hernandez, M. Carmen Garrido-Navas, Miguel Delgado-Ramirez, M. José Serrano

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

The triennial International Pigment Cell Conference (IPCC)

Neil F. Box, Lionel Larue, Prashiela Manga, Lluis Montoliu, Richard A. Spritz, Fabian V. Filipp

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Differential responses of MET activations to MET kinase inhibitor and neutralizing antibody

Jianqun Kou, Phillip R. Musich, Ben Staal, Liang Kang, Yuan Qin, Zhi Q. Yao, Boheng Zhang, Weizhong Wu, Angela Tam, Alan Huang, Huai-Xiang Hao, George F. Vande Woude, Qian Xie

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sex-specific associations between telomere length and candidate miRNA expression in placenta

Maria Tsamou, Dries S. Martens, Bianca Cox, Narjes Madhloum, Karen Vrijens, Tim S. Nawrot

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased circulating endothelial progenitor cells and improved short-term outcomes in acute non-cardioembolic stroke after hyperbaric oxygen therapy

Chen-Yu Chen, Re-Wen Wu, Nai-Wen Tsai, Mel S. Lee, Wei-Che Lin, Mei-Chi Hsu, Chih-Cheng Huang, Yun-Ru Lai, Chia-Te Kung, Hung-Chen Wang, Yu-Jih Su, Chih-Min Su, Sheng-Yuan Hsiao, Ben-Chung Cheng, Yi-Fang Chiang, Cheng-Hsien Lu

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

MAGIC: once upon a time in consent management—a FHIR® tale

Martin Bialke, Thomas Bahls, Lars Geidel, Henriette Rau, Arne Blumentritt, Sandra Pasewald, Robert Wolff, Jonas Steinmann, Tobias Bronsch, Björn Bergh, Galina Tremper, Martin Lablans, Frank Ückert, Stefan Lang, Tarik Idris, Wolfgang Hoffmann

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The diagnostic value of [18F]-FDG-PET/CT in assessment of radiation renal injury in Tibet minipigs model

Yu-Guang Tian, Min Yue, Bayaer Nashun, Shao-Jie Wu, Wei-Wang Gu, Yu-Jue Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The role of diffusion tensor imaging as an objective tool for the assessment of motor function recovery after paraplegia in a naturally-occurring large animal model of spinal cord injury

Adriano Wang-Leandro, Marc K. Hobert, Sabine Kramer, Karl Rohn, Veronika M. Stein, Andrea Tipold

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas

Nicolas Jonckheere, Isabelle Van Seuningen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A loss-of-function mutation p.T52S in RIPPLY3 is a potential predisposing genetic risk factor for Chinese Han conotruncal heart defect patients without the 22q11.2 deletion/duplication

Nanchao Hong, Erge Zhang, Qingjie Wang, Xiaoqing Zhang, Fen Li, Qihua Fu, Rang Xu, Yu Yu, Sun Chen, Yuejuan Xu, Kun Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer

Weiheng Wen, Peili Wu, Jitong Li, He Wang, Jia Sun, Hong Chen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Roles of airway smooth muscle dysfunction in chronic obstructive pulmonary disease

Furong Yan, Hongzhi Gao, Hong Zhao, Madhav Bhatia, Yiming Zeng

01.12.2018 | Protocol | Ausgabe 1/2018 Open Access

China Intracranial Aneurysm Project (CIAP): protocol for a registry study on a multidimensional prediction model for rupture risk of unruptured intracranial aneurysms

Junfan Chen, Jian Liu, Yisen Zhang, Zhongbin Tian, Kun Wang, Ying Zhang, Shiqing Mu, Ming Lv, Peng Jiang, ChuanZhi Duan, Hongqi Zhang, Yan Qu, Min He, Xinjian Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Systematic analysis of lncRNA–miRNA–mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer

Chun-Ni Fan, Lei Ma, Ning Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of serum β-catenin as a biomarker in patients with HBV-related liver diseases

Liang Duan, Qianfan Yang, Jun Yang, Qin Hu, Bo Wang, Pu Li, Weixian Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation

Weiyang Lou, Jing Chen, Bisha Ding, Danni Chen, Huilin Zheng, Donghai Jiang, Liang Xu, Chang Bao, Guoqiang Cao, Weimin Fan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

MiR-425 expression profiling in acute myeloid leukemia might guide the treatment choice between allogeneic transplantation and chemotherapy

Chen Yang, Tingting Shao, Huihui Zhang, Ninghan Zhang, Xiaoying Shi, Xuejiao Liu, Yao Yao, Linyan Xu, Shengyun Zhu, Jiang Cao, Hai Cheng, Zhiling Yan, Zhenyu Li, Mingshan Niu, Kailin Xu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Santa Rasa, Zaiga Nora-Krukle, Nina Henning, Eva Eliassen, Evelina Shikova, Thomas Harrer, Carmen Scheibenbogen, Modra Murovska, Bhupesh K. Prusty, the European Network on ME/CFS (EUROMENE)

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Cell adhesion-related gene somatic mutations are enriched in aggressive papillary thyroid microcarcinomas

Jianlu Song, Shouxin Wu, Xiaotian Xia, Yu Wang, Youben Fan, Zhili Yang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Subtype-specific associations between breast cancer risk polymorphisms and the survival of early-stage breast cancer

Fangmeng Fu, Wenhui Guo, Yuxiang Lin, Bangwei Zeng, Wei Qiu, Meng Huang, Chuan Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Surgical peritoneal stress creates a pro-metastatic niche promoting resistance to apoptosis via IL-8

Jennifer Pasquier, Fabien Vidal, Jessica Hoarau-Véchot, Claire Bonneau, Emile Daraï, Cyril Touboul, Arash Rafii

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Screening and identification of potential novel biomarker for diagnosis of complicated Plasmodium vivax malaria

Hargobinder Kaur, Rakesh Sehgal, Archit Kumar, Alka Sehgal, Devendra Bansal, Ali A. Sultan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The systemic immune-inflammation index is an independent predictor of survival for metastatic colorectal cancer and its association with the lymphocytic response to the tumor

Qian-Kun Xie, Ping Chen, Wan-Ming Hu, Peng Sun, Wen-Zhuo He, Chang Jiang, Peng-Fei Kong, Shou-Sheng Liu, Hai-Tian Chen, Yuan-Zhong Yang, Dan Wang, Lin Yang, Liang-Ping Xia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Molecular network-based identification of competing endogenous RNAs and mRNA signatures that predict survival in prostate cancer

Ning Xu, Yu-Peng Wu, Hu-Bin Yin, Xue-Yi Xue, Xin Gou

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Cytokines induced killer cells produced in good manufacturing practices conditions: identification of the most advantageous and safest expansion method in terms of viability, cellular growth and identity

Sara Castiglia, Aloe Adamini, Deborah Rustichelli, Laura Castello, Katia Mareschi, Giuseppe Pinnetta, Marco Leone, Alessandra Mandese, Ivana Ferrero, Giulia Mesiano, Franca Fagioli

01.12.2018 | Meeting report | Ausgabe 1/2018 Open Access

Tailoring cells for clinical needs: Meeting report from the Advanced Therapy in Healthcare symposium (October 28–29 2017, Doha, Qatar)

Sara Deola, Bella S. Guerrouahen, Heba Sidahmed, Anjud Al-Mohannadi, Muhammad Elnaggar, Ramaz Elsadig, Essam M. Abdelalim, Goran Petrovski, Massimo Gadina, Adrian Thrasher, Winfried S. Wels, Stephen P. Hunger, Ena Wang, Francesco M. Marincola, Cristina Maccalli, Chiara Cugno, ATH Consortium

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Plasma interleukin-37 is increased and inhibits the production of inflammatory cytokines in peripheral blood mononuclear cells in systemic juvenile idiopathic arthritis patients

Miao Feng, Min Kang, Feng He, Zonghui Xiao, Zhewei Liu, Hailan Yao, Jianxin Wu

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Establishment of urinary exosome-like vesicles isolation protocol for FHHNC patients and evaluation of different exosomal RNA extraction methods

M. Vall-Palomar, J. Arévalo, G. Ariceta, A. Meseguer

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A lipidated bi-epitope vaccine comprising of MHC-I and MHC-II binder peptides elicits protective CD4 T cell and CD8 T cell immunity against Mycobacterium tuberculosis

Pradeep K. Rai, Sathi Babu Chodisetti, Sudeep K. Maurya, Sajid Nadeem, Weiguang Zeng, Ashok K. Janmeja, David C. Jackson, Javed N. Agrewala

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The development of a Biobank of cancer tissue samples from World Trade Center responders

Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, Michael Donovan, Emanuela Taioli

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Boswellia frereana suppresses HGF-mediated breast cancer cell invasion and migration through inhibition of c-Met signalling

Christian Parr, Ahmed Y. Ali

01.12.2018 | Research | Ausgabe 1/2018 Open Access

p53 modeling as a route to mesothelioma patients stratification and novel therapeutic identification

Kun Tian, Emyr Bakker, Michelle Hussain, Alice Guazzelli, Hasen Alhebshi, Parisa Meysami, Constantinos Demonacos, Jean-Marc Schwartz, Luciano Mutti, Marija Krstic-Demonacos

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Harnessing Qatar Biobank to understand type 2 diabetes and obesity in adult Qataris from the First Qatar Biobank Project

Ehsan Ullah, Raghvendra Mall, Reda Rawi, Naima Moustaid-Moussa, Adeel A. Butt, Halima Bensmail

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Upregulation of miR-196b-5p attenuates BCG uptake via targeting SOCS3 and activating STAT3 in macrophages from patients with long-term cigarette smoking-related active pulmonary tuberculosis

Yaoqin Yuan, Dongzi Lin, Long Feng, Mingyuan Huang, Huimin Yan, Yumei Li, Yinwen Chen, Bihua Lin, Yan Ma, Ziyu Ye, Yuezhi Mei, Xiaolin Yu, Keyuan Zhou, Qunzhou Zhang, Tao Chen, Jincheng Zeng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Joint associations of serum uric acid and ALT with NAFLD in elderly men and women: a Chinese cross-sectional study

Huanhuan Yang, Deming Li, Xiaochao Song, Fang Liu, Xinjing Wang, Qinghua Ma, Xi Zhang, Xinli Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Unique true predicted neoantigens (TPNAs) correlates with anti-tumor immune control in HCC patients

Annacarmen Petrizzo, Maria Tagliamonte, Angela Mauriello, Valerio Costa, Marianna Aprile, Roberta Esposito, Andrea Caporale, Antonio Luciano, Claudio Arra, Maria Lina Tornesello, Franco M. Buonaguro, Luigi Buonaguro

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study

Yoshiya Horimoto, Emi Tokuda, Fumi Murakami, Toshitaka Uomori, Takanori Himuro, Katsuya Nakai, Gotaro Orihata, Kotaro Iijima, Shinsaku Togo, Hideo Shimizu, Mitsue Saito

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

A modified method for isolation of human cardiomyocytes to model cardiac diseases

Guang-ran Guo, Liang Chen, Man Rao, Kai Chen, Jiang-ping Song, Sheng-shou Hu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Heterogeneity of insulin resistance and beta cell dysfunction in gestational diabetes mellitus: a prospective cohort study of perinatal outcomes

Yingfeng Liu, Wolin Hou, Xiyan Meng, Weijing Zhao, Jiemin Pan, Junling Tang, Yajuan Huang, Minfang Tao, Fang Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Podocalyxin-like protein as a predictive biomarker for benefit of neoadjuvant chemotherapy in resectable gastric and esophageal adenocarcinoma

David Borg, Anna H. Larsson, Charlotta Hedner, Björn Nodin, Anders Johnsson, Karin Jirström

01.12.2018 | Methodology | Ausgabe 1/2018 Open Access

Stability enhancement of clinical grade multipotent mesenchymal stromal cell-based products

Clémentine Mirabel, Eduard Puente-Massaguer, Anna del Mazo-Barbara, Blanca Reyes, Philip Morton, Francesc Gòdia, Joaquim Vives

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Genomic approaches in the search for molecular biomarkers in chronic kidney disease

M. Cañadas-Garre, K. Anderson, J. McGoldrick, A. P. Maxwell, A. J. McKnight

01.12.2018 | Research | Ausgabe 1/2018 Open Access

iTRAQ-based quantitative analysis of age-specific variations in salivary proteome of caries-susceptible individuals

Kun Wang, Xiuqing Wang, Sainan Zheng, Yumei Niu, Wenyue Zheng, Xi Qin, Zhongcheng Li, Junyuan Luo, Wentao Jiang, Xuedong Zhou, Wei Li, Linglin Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

CD25 and TGF-β blockade based on predictive integrated immune ratio inhibits tumor growth in pancreatic cancer

Ning Pu, Guochao Zhao, Hanlin Yin, Jian-ang Li, Abulimiti Nuerxiati, Dansong Wang, Xuefeng Xu, Tiantao Kuang, Dayong Jin, Wenhui Lou, Wenchuan Wu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

An increase in myocardial 18-fluorodeoxyglucose uptake is associated with left ventricular ejection fraction decline in Hodgkin lymphoma patients treated with anthracycline

Matteo Sarocchi, Matteo Bauckneht, Eleonora Arboscello, Selene Capitanio, Cecilia Marini, Silvia Morbelli, Maurizio Miglino, Angela Giovanna Congiu, Giorgio Ghigliotti, Manrico Balbi, Claudio Brunelli, Gianmario Sambuceti, Pietro Ameri, Paolo Spallarossa

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The immune response to sub-clinical mastitis is impaired in HIV-infected women

Roxane Schaub, Stéphanie Badiou, Johannes Viljoen, Pierre Dujols, Karine Bolloré, Philippe Van de Perre, Marie-Louise Newell, Ruth Bland, Nicolas Nagot, Edouard Tuaillon

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Targeted deletion of Insm2 in mice result in reduced insulin secretion and glucose intolerance

Lin Wang, Zhong Sheng Sun, Bingwu Xiang, Chi-ju Wei, Yan Wang, Kevin Sun, Guanjie Chen, Michael S. Lan, Gilberto N. Carmona, Abner L. Notkins, Tao Cai

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Peptide vaccine against chikungunya virus: immuno-informatics combined with molecular docking approach

Muhammad Tahir ul Qamar, Amna Bari, Muhammad Muzammal Adeel, Arooma Maryam, Usman Ali Ashfaq, Xiaoyong Du, Iqra Muneer, Hafiz Ishfaq Ahmad, Jia Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Galectin-3 predicts response and outcomes after cardiac resynchronization therapy

Clémentine Andre, Eric Piver, Romain Perault, Arnaud Bisson, Julien Pucheux, Emmanuelle Vermes, Bertrand Pierre, Laurent Fauchier, Dominique Babuty, Nicolas Clementy

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Fragment size and level of cell-free DNA provide prognostic information in patients with advanced pancreatic cancer

Morten Lapin, Satu Oltedal, Kjersti Tjensvoll, Tove Buhl, Rune Smaaland, Herish Garresori, Milind Javle, Nils Idar Glenjen, Bente Kristin Abelseth, Bjørnar Gilje, Oddmund Nordgård

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Analysis of longitudinal semicontinuous data using marginalized two-part model

Miran A. Jaffa, Mulugeta Gebregziabher, Sara M. Garrett, Deirdre K. Luttrell, Kenneth E. Lipson, Louis M. Luttrell, Ayad A. Jaffa

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Periostin involved in the activated hepatic stellate cells-induced progression of residual hepatocellular carcinoma after sublethal heat treatment: its role and potential for therapeutic inhibition

Rui Zhang, Xia-Hui Lin, Min Ma, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Rong-Xin Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Status of programmed death-ligand 1 expression in sarcomas

Hyung Kyu Park, Mingi Kim, Minjung Sung, Seung Eun Lee, Yu Jin Kim, Yoon-La Choi

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Is it possible to overcome issues of external validity in preclinical animal research? Why most animal models are bound to fail

Pandora Pound, Merel Ritskes-Hoitinga

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Simvastatin attenuates tibial bone loss in rats with type 1 diabetes and periodontitis

Ae Ri Kim, Ji-Hye Kim, Aeryun Kim, Yongsung Sohn, Jeong-Heon Cha, Eun-Jung Bak, Yun-Jung Yoo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Significance of intrinsic breast cancer subtypes on the long-term prognosis after neoadjuvant chemotherapy

Wataru Goto, Shinichiro Kashiwagi, Koji Takada, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influence of FTO rs9939609 and Mediterranean diet on body composition and weight loss: a randomized clinical trial

Laura Di Renzo, Giorgia Cioccoloni, Simone Falco, Ludovico Abenavoli, Alessandra Moia, Paola Sinibaldi Salimei, Antonino De Lorenzo

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

High density lipoprotein cholesterol and proteome in SR-B1 KO mice: lost in precipitation

Susana Contreras-Duarte, Nicolás Santander, Ruth Birner-Gruenberger, Christian Wadsack, Attilio Rigotti, Dolores Busso

01.12.2018 | Research | Ausgabe 1/2018 Open Access

GAP43, a novel metastasis promoter in non-small cell lung cancer

Fanrong Zhang, Lisha Ying, Jiaoyue Jin, Jianguo Feng, Kaiyan Chen, Minran Huang, Yingxue Wu, Herbert Yu, Dan Su

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Platycodin D inhibits platelet function and thrombus formation through inducing internalization of platelet glycoprotein receptors

Qi Luo, Guangyu Wei, Xiaoqing Wu, Kai Tang, Mengdi Xu, Yulu Wu, Yun Liu, Xiaoqian Li, Zengtian Sun, Wen Ju, Kunming Qi, Chong Chen, Zhiling Yan, Hai Cheng, Feng Zhu, Zhenyu Li, Lingyu Zeng, Kailin Xu, Jianlin Qiao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Association of serum angiopoietin-2 with malnutrition, inflammation, atherosclerosis and valvular calcification syndrome and outcome in peritoneal dialysis patients: a prospective cohort study

Xiaoxiao Yang, He Zhang, Yuanyuan Shi, Zanzhe Yu, Hao Yan, Zhaohui Ni, Jiaqi Qian, Wei Fang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury

Qinghai Zhang, Xun Liu, Na li, Jihong Zhang, Jianmin Yang, Peili Bu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Deficiency in interleukin-18 promotes differentiation of brown adipose tissue resulting in fat accumulation despite dyslipidemia

Kyosuke Yamanishi, Seishi Maeda, Sachi Kuwahara-Otani, Takuya Hashimoto, Kaoru Ikubo, Keiichiro Mukai, Keiji Nakasho, Naomi Gamachi, Yosif El-Darawish, Wen Li, Daisuke Okuzaki, Yuko Watanabe, Hiromichi Yamanishi, Haruki Okamura, Hisato Matsunaga

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Associations of immunological factors with metabolic syndrome and its characteristic elements in Chinese centenarians

Shihui Fu, Yao Yao, Faqin Lv, Fu Zhang, Yali Zhao, Fuxin Luan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Serum uromodulin and progression of kidney disease in patients with chronic kidney disease

Li Lv, Jinwei Wang, Bixia Gao, Liang Wu, Fang Wang, Zhao Cui, Kevin He, Luxia Zhang, Min Chen, Ming-Hui Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NLRC5: potential novel non-invasive biomarker for predicting and reflecting the progression of IgA nephritis

Yusa Chen, Huihui Li, Chenggen Xiao, Xiangli Zeng, Xiangcheng Xiao, Qiaoling Zhou, Ping Xiao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Possibility of avoiding axillary lymph node dissection by immune microenvironment monitoring in preoperative chemotherapy for breast cancer

Koji Takada, Shinichiro Kashiwagi, Wataru Goto, Yuka Asano, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi, Yan Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinicopathologic implication of PD-L1 and phosphorylated STAT3 expression in diffuse large B cell lymphoma

Hyun Jung Kwon, Jeong Mi Yang, Jeong-Ok Lee, Jong Seok Lee, Jin Ho Paik

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Optimizing bone wound healing using BMP2 with absorbable collagen sponge and Talymed nanofiber scaffold

Emily L. Durham, R. Nicole Howie, SarahRose Hall, Nicholas Larson, Brayden Oakes, Reed Houck, Zachary Grey, Martin Steed, Amanda C. LaRue, Robin Muise-Helmericks, James Cray

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Evaluation of four clinical laboratory parameters for the diagnosis of myalgic encephalomyelitis

Kenny L. De Meirleir, Tatjana Mijatovic, Krishnamurthy Subramanian, Karen A. Schlauch, Vincent C. Lombardi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

N-glycosylation patterns of plasma proteins and immunoglobulin G in chronic obstructive pulmonary disease

Tamara Pavić, Dario Dilber, Domagoj Kifer, Najda Selak, Toma Keser, Đivo Ljubičić, Andrea Vukić Dugac, Gordan Lauc, Lada Rumora, Olga Gornik

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Effects of physiological aging factor on bone tissue engineering repair based on fetal BMSCs

Dingyu Wu, Zhenxing Wang, Zhiwei Zheng, Yingnan Geng, Zhanzhao Zhang, Qiannan Li, Quan Zhou, Yilin Cao, Zhi-Yong Zhang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Feasibility study of dual parametric 2D histogram analysis of breast lesions with dynamic contrast-enhanced and diffusion-weighted MRI

Yanqiong Chen, Bin Wu, Hui Liu, Dan Wang, Yajia Gu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Therapeutic value of surgical paraaortic staging in locally advanced cervical cancer: a multicenter cohort analysis from the FRANCOGYN study group

Yohann Dabi, Vanille Simon, Xavier Carcopino, Sofiane Bendifallah, Lobna Ouldamer, Vincent Lavoue, Geoffroy Canlorbe, Emilie Raimond, Charles Coutant, Olivier Graesslin, Pierre Collinet, Alexandre Bricou, Emile Daraï, Cyrille Huchon, Marcos Ballester, Bassam Haddad, Cyril Touboul, For the Groupe de Recherche FRANCOGYN

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Evaluation of the prognostic value of paraoxonase 1 in the recurrence and metastasis of hepatocellular carcinoma and establishment of a liver-specific predictive model of survival

Zheng Yu, Qifeng Ou, Fan Chen, Jiong Bi, Wen Li, Jieyi Ma, Rongchang Wang, Xiaohui Huang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

Xingxiang Pu, Ran Zhang, Li Wang, Yungchang Chen, Yi Xu, Apar Pataer, Ismail M. Meraz, Xiaoshan Zhang, Shuhong Wu, Lin Wu, Dan Su, Weimin Mao, John V. Heymach, Jack A. Roth, Stephen G. Swisher, Bingliang Fang

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Epicutaneous immunotherapy in rhino-conjunctivitis and food allergies: a review of the literature

Susanna Esposito, Chiara Isidori, Alessandra Pacitto, Cristina Salvatori, Laura Sensi, Franco Frati, Giuseppe Di Cara, Francesco Marcucci

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mutational and phenotypic spectrum of OTOF-related auditory neuropathy in Koreans: eliciting reciprocal interaction between bench and clinics

Bong Jik Kim, Jeong Hun Jang, Jin Hee Han, Hye-Rim Park, Doo Yi Oh, Seungmin Lee, Min Young Kim, Ah Reum Kim, Chung Lee, Nayoung K. D. Kim, Woong-Yang Park, Yun-Hoon Choung, Byung Yoon Choi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Early goal-directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials

Xian-Fei Ding, Zi-Yue Yang, Zhen-Tao Xu, Li-Feng Li, Bo Yuan, Li-Na Guo, Le-Xin Wang, Xi Zhu, Tong-Wen Sun

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection

Yue Zhang, Hui Zhang, Minghui An, Bin Zhao, Haibo Ding, Zining Zhang, Youwen He, Hong Shang, Xiaoxu Han

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Scrub typhus and depression: a nationwide cohort analysis

Ying-Chuan Wang, Chun-Hsiang Chiu, Cheng-Li Lin, Feng-You Lee, Kuang-Hsi Chang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Machine-learned models using hematological inflammation markers in the prediction of short-term acute coronary syndrome outcomes

Konrad Pieszko, Jarosław Hiczkiewicz, Paweł Budzianowski, Janusz Rzeźniczak, Jan Budzianowski, Jerzy Błaszczyński, Roman Słowiński, Paweł Burchardt

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Autoimmune disorders but not heparin are associated with cell-free fetal DNA test failure

Yohann Dabi, Sarah Guterman, Jacques C. Jani, Alexandra Letourneau, Adèle Demain, Pascale Kleinfinger, Laurence Lohmann, Jean-Marc Costa, Alexandra Benachi

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Reviewing the role of healthy volunteer studies in drug development

Joyson J. Karakunnel, Nam Bui, Latha Palaniappan, Keith T. Schmidt, Kenneth W. Mahaffey, Briggs Morrison, William D. Figg, Shivaani Kummar

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The treatment value of IL-1β monoclonal antibody under the targeting location of alpha-methyl-l-tryptophan and superparamagnetic iron oxide nanoparticles in an acute temporal lobe epilepsy model

Yanli Wang, Yanling Wang, Ran Sun, Xingrao Wu, Xu Chu, Shuhu Zhou, Xibin Hu, Lingyun Gao, Qingxia Kong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis

Clara Benna, Senthilkumar Rajendran, Giovanna Spiro, Saveria Tropea, Paolo Del Fiore, Carlo Riccardo Rossi, Simone Mocellin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Immunological effects of the intraparenchymal administration of allogeneic and autologous adipose-derived mesenchymal stem cells after the acute phase of middle cerebral artery occlusion in rats

Zhang Yu, Tang Wenyan, Su Xuewen, Dong Baixiang, Wang Qian, Wang Zhaoyan, Yang Yinxiang, Qu Suqing, Luan Zuo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Diffusion-weighted imaging and diffusion kurtosis imaging for early evaluation of the response to docetaxel in rat epithelial ovarian cancer

Su-juan Yuan, Tian-kui Qiao, Jin-Wei Qiang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

microRNA expression pattern as an ancillary prognostic signature for radiotherapy

An-Lun Li, Tao-Sang Chung, Yao-Ning Chan, Chien-Lung Chen, Shih-Chieh Lin, Yun-Ru Chiang, Chen-Huan Lin, Chi-Ching Chen, Nianhan Ma

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Increased risk of chronic fatigue syndrome following burn injuries

Shin-Yi Tsai, Cheng-Li Lin, Shou-Chuan Shih, Cheng-Wei Hsu, Kam-Hang Leong, Chien-Feng Kuo, Chon-Fu Lio, Yu-Tien Chen, Yan-Jiun Hung, Leiyu Shi

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Mitochondrial haplogroup H is related to CD4+ T cell recovery in HIV infected patients starting combination antiretroviral therapy

Luz M. Medrano, Mónica Gutiérrez-Rivas, Julià Blanco, Marcial García, María A. Jiménez-Sousa, Yolanda M. Pacheco, Marta Montero, José Antonio Iribarren, Enrique Bernal, Onofre Juan Martínez, José M. Benito, Norma Rallón, Salvador Resino, CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS/EPICLIN 10_2015

01.12.2018 | Research | Ausgabe 1/2018 Open Access

l-Fucose ameliorates high-fat diet-induced obesity and hepatic steatosis in mice

Guangyan Wu, Mengwei Niu, Wenli Tang, Jingjuan Hu, Guoquan Wei, Zhanke He, Yangping Chen, Yong Jiang, Peng Chen

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Application of expanded genetic analysis in the diagnosis of familial hypercholesterolemia in patients with very early-onset coronary artery disease

Ye-Xuan Cao, Na-Qiong Wu, Di Sun, Hui-Hui Liu, Jing-Lu Jin, Sha Li, Yuan-Lin Guo, Cheng-Gang Zhu, Ying Gao, Qiu-Ting Dong, Geng Liu, Qian Dong, Jian-Jun Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Real-world use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/β-blocks in Chinese patients before acute myocardial infarction occurs: patient characteristics and hospital follow-up

Xuhe Gong, Xiaosong Ding, Hui Chen, Hongwei Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Dexmedetomidine expands monocytic myeloid-derived suppressor cells and promotes tumour metastasis after lung cancer surgery

Xiaosan Su, Yaodong Fan, Liu Yang, Jie Huang, Fei Qiao, Yu Fang, Jun Wang

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A heterogeneous label propagation approach to explore the potential associations between miRNA and disease

Xing Chen, De-Hong Zhang, Zhu-Hong You

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Tel-eVax: a genetic vaccine targeting telomerase for treatment of canine lymphoma

Joseph A. Impellizeri, Alessandra Gavazza, Eliana Greissworth, Anna Crispo, Maurizio Montella, Gennaro Ciliberto, George Lubas, Luigi Aurisicchio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Posterior HOX genes and HOTAIR expression in the proximal and distal colon cancer pathogenesis

Fabiana Tatangelo, Annabella Di Mauro, Giosuè Scognamiglio, Gabriella Aquino, Antonio Lettiero, Paolo Delrio, Antonio Avallone, Monica Cantile, Gerardo Botti

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Measurement of hepatitis B virus DNA in fresh versus processed dentin from chronically infected patients

Inwoong Um, Sungweon Choi, Youngkyun Kim, Kangmi Pang, Jongho Lee, Minsun Lee, Bongju Kim

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrin ανβ5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats

Gianluca Lorenzo Perrucci, Veronica Antonietta Barbagallo, Maria Corlianò, Delfina Tosi, Rosaria Santoro, Patrizia Nigro, Paolo Poggio, Gaetano Bulfamante, Federico Lombardi, Giulio Pompilio

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Gut microbiota dysbiosis in male patients with chronic traumatic complete spinal cord injury

Chao Zhang, Wenhao Zhang, Jie Zhang, Yingli Jing, Mingliang Yang, Liangjie Du, Feng Gao, Huiming Gong, Liang Chen, Jun Li, Hongwei Liu, Chuan Qin, Yanmei Jia, Jiali Qiao, Bo Wei, Yan Yu, Hongjun Zhou, Zhizhong Liu, Degang Yang, Jianjun Li

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Diverse roles of macrophage polarization in aortic aneurysm: destruction and repair

Zhao Cheng, Yang-zhao Zhou, Yin Wu, Qi-ying Wu, Xiao-bo Liao, Xian-ming Fu, Xin-min Zhou

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up

Christopher Centeno, Mitchell Sheinkop, Ehren Dodson, Ian Stemper, Christopher Williams, Matthew Hyzy, Thomas Ichim, Michael Freeman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer

Monika Pizon, Daniel Lux, Ulrich Pachmann, Katharina Pachmann, Dorothea Schott

01.12.2018 | Research | Ausgabe 1/2018 Open Access

A novel semi-supervised model for miRNA-disease association prediction based on -norm graph

Cheng Liang, Shengpeng Yu, Ka-Chun Wong, Jiawei Luo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Implementing a comprehensive translational oncology platform: from molecular testing to actionability

Zahi I. Mitri, Swapnil Parmar, Brett Johnson, Annette Kolodzie, Jamie M. Keck, Max Morris, Alexander R. Guimaraes, Brooke R. Beckett, Uma Borate, Charles D. Lopez, Kathleen A. Kemmer, Joshi J. Alumkal, Tomasz M. Beer, Christopher L. Corless, Gordon B. Mills, Joe W. Gray, Raymond C. Bergan

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Clinical significance of soluble immunoglobulins A and G and their coated bacteria in feces of patients with inflammatory bowel disease

Ritian Lin, Hongwei Chen, Weigang Shu, Mingming Sun, Leilei Fang, Yanhong Shi, Zhi Pang, Wei Wu, Zhanju Liu

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The ruxolitinib effect: understanding how molecular pathogenesis and epigenetic dysregulation impact therapeutic efficacy in myeloproliferative neoplasms

Graeme Greenfield, Suzanne McPherson, Ken Mills, Mary Frances McMullin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Circular RNA regulatory network reveals cell–cell crosstalk in acute myeloid leukemia extramedullary infiltration

Chengfang Lv, Lili Sun, Zhibo Guo, Huibo Li, Desheng Kong, Bingqi Xu, Leilei Lin, Tianjiao Liu, Dan Guo, Jin Zhou, Yinghua Li

01.12.2018 | Research | Ausgabe 1/2018 Open Access

The roles of HLA-DQB1 gene polymorphisms in hepatitis B virus infection

Guojin Ou, Haixia Xu, Hao Yu, Xiao Liu, Liu Yang, Xin Ji, Jue Wang, Zhong Liu

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prediction and prognostic significance of BCAR3 expression in patients with multiple myeloma

Weilong Zhang, Yuansheng Lin, Xiaoni Liu, Xue He, Ye Zhang, Wei Fu, Zuozhen Yang, Ping Yang, Jing Wang, Kai Hu, Xiuru Zhang, Weiyou Liu, Xiaoliang Yuan, Hongmei Jing

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Pro-atherosclerotic disturbed flow disrupts caveolin-1 expression, localization, and function via glycocalyx degradation

Ian C. Harding, Ronodeep Mitra, Solomon A. Mensah, Ira M. Herman, Eno E. Ebong

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Preoperative systemic immune-inflammation index predicts prognosis of patients with oral squamous cell carcinoma after curative resection

Pengfei Diao, Yaping Wu, Jin Li, Wei Zhang, Rong Huang, Chen Zhou, Yanling Wang, Jie Cheng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer

Yoshinaga Okugawa, Yuji Toiyama, Kunitoshi Shigeyasu, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Takashi Ichikawa, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junichiro Hiro, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki, Ajay Goel

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Towards the use of diffuse reflectance spectroscopy for real-time in vivo detection of breast cancer during surgery

Lisanne L. de Boer, Torre M. Bydlon, Frederieke van Duijnhoven, Marie-Jeanne T. F. D. Vranken Peeters, Claudette E. Loo, Gonneke A. O. Winter-Warnars, Joyce Sanders, Henricus J. C. M. Sterenborg, Benno H. W. Hendriks, Theo J. M. Ruers

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of a multidimensional transcriptome signature for survival prediction of postoperative glioblastoma multiforme patients

Wei-Zhen Gao, Lie-Mei Guo, Tian-Qi Xu, Yu-Hua Yin, Feng Jia

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Identification of a novel role of IL-13Rα2 in human Glioblastoma multiforme: interleukin-13 mediates signal transduction through AP-1 pathway

Rukmini Bhardwaj, Akiko Suzuki, Pamela Leland, Bharat H. Joshi, Raj K. Puri

01.12.2018 | Research | Ausgabe 1/2018 Open Access

NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker

Gangqiang Guo, Huijing Wang, Xinyu Shi, Lele Ye, Kai Wu, Kangmin Lin, Sisi Ye, Baoqing Li, Huidi Zhang, Qiaoai Lin, Shuang Ye, Xiangyang Xue, Chaosheng Chen

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Intermittent versus continuous energy restriction on weight loss and cardiometabolic outcomes: a systematic review and meta-analysis of randomized controlled trials

Iolanda Cioffi, Andrea Evangelista, Valentina Ponzo, Giovannino Ciccone, Laura Soldati, Lidia Santarpia, Franco Contaldo, Fabrizio Pasanisi, Ezio Ghigo, Simona Bo

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Integrated analysis of dysregulated long non-coding RNAs/microRNAs/mRNAs in metastasis of lung adenocarcinoma

Lifeng Li, Mengle Peng, Wenhua Xue, Zhirui Fan, Tian Wang, Jingyao Lian, Yunkai Zhai, Wenping Lian, Dongchun Qin, Jie Zhao

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Biomarkers from circulating neutrophil transcriptomes have potential to detect unruptured intracranial aneurysms

Vincent M. Tutino, Kerry E. Poppenberg, Lu Li, Hussain Shallwani, Kaiyu Jiang, James N. Jarvis, Yijun Sun, Kenneth V. Snyder, Elad I. Levy, Adnan H. Siddiqui, John Kolega, Hui Meng

01.12.2018 | Research | Ausgabe 1/2018 Open Access

FGFR1 expression defines clinically distinct subtypes in pancreatic cancer

Farhan Haq, You-Na Sung, Inkeun Park, Mahmood Akhtar Kayani, Faizah Yousuf, Seung-Mo Hong, Sung-Min Ahn

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