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Zeitschrift

Journal of Translational Medicine

Journal of Translational Medicine 1/2019

Ausgabe 1/2019

Inhaltsverzeichnis ( 420 Artikel )

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy

Yukiko Niwa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Masamichi Hayashi, Mitsuru Tashiro, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prediction of postoperative complications of pediatric cataract patients using data mining

Kai Zhang, Xiyang Liu, Jiewei Jiang, Wangting Li, Shuai Wang, Lin Liu, Xiaojing Zhou, Liming Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Exosomes of pasteurized milk: potential pathogens of Western diseases

Bodo C. Melnik, Gerd Schmitz

01.12.2019 | Research | Ausgabe 1/2019 Open Access

An innovative total temporomandibular joint prosthesis with customized design and 3D printing additive fabrication: a prospective clinical study

JiSi Zheng, XuZhuo Chen, WenBo Jiang, ShanYong Zhang, MinJie Chen, Chi Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Microbiome–metabolome reveals the contribution of gut–kidney axis on kidney disease

Yuan-Yuan Chen, Dan-Qian Chen, Lin Chen, Jing-Ru Liu, Nosratola D. Vaziri, Yan Guo, Ying-Yong Zhao

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

Complement factors C3a and C5a mimick a proinflammatory microenvironment and increase HBV IGRA sensitivity

Katharina Bröker, Robin Terzenbach, Frank Bentzien, Stefan Lüth, Werner Dammermann

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of potential miRNA–mRNA regulatory network contributing to pathogenesis of HBV-related HCC

Weiyang Lou, Jingxing Liu, Bisha Ding, Danni Chen, Liang Xu, Jun Ding, Donghai Jiang, Lin Zhou, Shusen Zheng, Weimin Fan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease

Giovanni Tarantino, Susan Costantini, Vincenzo Citro, Paolo Conforti, Francesca Capone, Angela Sorice, Domenico Capone

01.12.2019 | Research | Ausgabe 1/2019 Open Access

PRAME promotes epithelial-to-mesenchymal transition in triple negative breast cancer

Ghaneya Al-Khadairi, Adviti Naik, Remy Thomas, Boshra Al-Sulaiti, Shaheen Rizly, Julie Decock

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation

Michael Scarpone, Daniel Kuebler, Andrew Chambers, Carlo Maria De Filippo, Mariangela Amatuzio, Thomas E. Ichim, Amit N. Patel, Eugenio Caradonna

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Establishment of clinical diagnosis model of Graves’ disease and Hashimoto’s thyroiditis

Zhaohui Cui, Zhixiao Wang, Xiaoyun Liu, Yun Cai, Xinyu Xu, Tao Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro, Gianluigi Zaza

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinical verification of the relationship between smoking and the immune microenvironment of breast cancer

Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa, Masaichi Ohira

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A novel signature derived from immunoregulatory and hypoxia genes predicts prognosis in liver and five other cancers

Wai Hoong Chang, Donall Forde, Alvina G. Lai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Longitudinal genome-wide DNA methylation analysis uncovers persistent early-life DNA methylation changes

Raúl F. Pérez, Pablo Santamarina, Juan Ramón Tejedor, Rocío G. Urdinguio, Julio Álvarez-Pitti, Pau Redon, Agustín F. Fernández, Mario F. Fraga, Empar Lurbe

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis

Hong-Ki Min, JeongWon Choi, Seon-Yeong Lee, Hyeon-Beom Seo, KyungAh Jung, Hyun Sik Na, Jun-Geol Ryu, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Microbubble-mediated delivery of human adenoviruses does not elicit innate and adaptive immunity response in an immunocompetent mouse model of prostate cancer

Flavia De Carlo, Litty Thomas, Bell Brooke, Elliot T. Varney, Rounak Nande, Olivia Boskovic, Gailen D. Marshall, Pier Paolo Claudio, Candace M. Howard

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α

Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Characteristics of T cell receptor repertoires of patients with acute myocardial infarction through high-throughput sequencing

Zhixiong Zhong, Heming Wu, Qifeng Zhang, Wei Zhong, Pingsen Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo

Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese, Volker J. Schmidt

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture

Shutong Liu, David F. Stroncek, Yingdong Zhao, Victoria Chen, Rongye Shi, Jinguo Chen, Jiaqiang Ren, Hui Liu, Hee Joon Bae, Steven L. Highfill, Ping Jin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Regeneration of a neoartery through a completely autologous acellular conduit in a minipig model: a pilot study

Tao Wang, Nianguo Dong, Huimin Yan, Sze Yue Wong, Wen Zhao, Kang Xu, Dong Wang, Song Li, Xuefeng Qiu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating miR-3659 may be a potential biomarker of dyslipidemia in patients with obesity

Liu Miao, Rui-Xing Yin, Shang-Ling Pan, Shuo Yang, De-Zhai Yang, Wei-Xiong Lin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Hypercholesterolemia-induced increase in plasma oxidized LDL abrogated pro angiogenic response in kidney grafts

Thomas Kerforne, Frédéric Favreau, Tackwa Khalifeh, Souleymane Maiga, Geraldine Allain, Antoine Thierry, Manuel Dierick, Edouard Baulier, Clara Steichen, Thierry Hauet

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinical and genetic risk factors for Fulvestrant treatment in post-menopause ER-positive advanced breast cancer patients

Jingyu Liu, Jing Li, Hui Wang, Yikai Wang, Qiongzhi He, Xuefeng Xia, Zhe-Yu Hu, Quchang Ouyang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Serum protein signature of coronary artery disease in type 2 diabetes mellitus

Ramu Adela, Podduturu Naveen Chander Reddy, Tarini Shankar Ghosh, Suruchi Aggarwal, Amit Kumar Yadav, Bhabatosh Das, Sanjay K. Banerjee

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The emerging role of WISP proteins in tumorigenesis and cancer therapy

Yi Liu, Yizuo Song, Miaomiao Ye, Xiaoli Hu, Z. Peter Wang, Xueqiong Zhu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Effectiveness of two different dose administration regimens of an IL-15 superagonist complex (ALT-803) in an orthotopic bladder cancer mouse model

Hideki Furuya, Owen T. M. Chan, Ian Pagano, Chengjun Zhu, Nari Kim, Rafael Peres, Kanani Hokutan, Sarah Alter, Peter Rhode, Charles J. Rosser

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Systemic immune-inflammation index predicts prognosis of patients with advanced pancreatic cancer

Ke Zhang, Yong-Qiang Hua, Dan Wang, Lian-Yu Chen, Cai-Jun Wu, Zhen Chen, Lu-Ming Liu, Hao Chen

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Revisiting IDO and its value as a predictive marker for anti-PD-1 resistance

Peter Kim Moon, Stephanie Tran, Paras Singh Minhas

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Three-dimensional nanostructured substrates enable dynamic detection of ALK-rearrangement in circulating tumor cells from treatment-naive patients with stage III/IV lung adenocarcinoma

Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang, Zun-fu Ke

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Mechanisms by which hydrogen sulfide attenuates muscle function following ischemia–reperfusion injury: effects on Akt signaling, mitochondrial function, and apoptosis

Michael D. Wetzel, Joseph C. Wenke

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden

Stephen P. Rushton, Roy A. Sanderson, Peter J. Diggle, Mark D. F. Shirley, Alasdair P. Blain, Iain Lake, James A. Maas, William D. K. Reid, Jo Hardstaff, Nicola Williams, Natalia R. Jones, Daniel Rigby, Norval J. C. Strachan, Ken J. Forbes, Paul R. Hunter, Thomas J. Humphrey, Sarah J. O’Brien

01.12.2019 | Research | Ausgabe 1/2019 Open Access

An integrative genomic analysis of transcriptional profiles identifies characteristic genes and patterns in HIV-infected long-term non-progressors and elite controllers

Jiwei Ding, Ling Ma, Jianyuan Zhao, Yongli Xie, Jinming Zhou, Xiaoyu Li, Shan Cen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Macrophages are necessary for skin regeneration during tissue expansion

Jianke Ding, Lei Lei, Shiqiang Liu, Yu Zhang, Zhou Yu, Yingjun Su, Xianjie Ma

01.12.2019 | Research | Ausgabe 1/2019 Open Access

LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production

Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang, Ying Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia

Zhidai Liu, Tingting Zhou, Xing Han, Tingyuan Lang, Shan Liu, Penghui Zhang, Haiyan Liu, Kexing Wan, Jie Yu, Liang Zhang, Liyan Chen, Roger W. Beuerman, Bin Peng, Lei Zhou, Lin Zou

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

DRAP: a toolbox for drug response analysis and visualization tailored for preclinical drug testing on patient-derived xenograft models

Quanxue Li, Wentao Dai, Jixiang Liu, Yi-Xue Li, Yuan-Yuan Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Peripheral T cell receptor beta immune repertoire is promptly reconstituted after acute myocardial infarction

Dan Li, Longgang Hu, Qing Liang, Cuijuan Zhang, Yunzhen Shi, Bin Wang, Kejia Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

New risk score for predicting progression of membranous nephropathy

Hu Xiaofan, Xu Jing, Gao Chenni, Wu Yifan, Yu Xialian, Lin Li, Ren Hong, Zhang Wen, Wang Weiming, Pan Xiaoxia, Xie Jingyuan, Chen Nan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

How stakeholder engagement influenced a randomized comparative effectiveness trial testing two Diabetes Prevention Program interventions in a Marshallese Pacific Islander Community

Pearl A. McElfish, Britni L. Ayers, Holly C. Felix, Christopher R. Long, Zoran Bursac, Joseph Keawe‘aimoku Kaholokula, Sheldon Riklon, Williamina Bing, Anita Iban, Karen Hye-cheon Kim Yeary

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The phylogeny of 48 alleles, experimentally verified at 21 kb, and its application to clinical allele detection

Kshitij Srivastava, Kurt R. Wollenberg, Willy A. Flegel

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

Data-driven clinical decision processes: it’s time

Enrico Capobianco

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Bioinformatic gene analysis for potential biomarkers and therapeutic targets of atrial fibrillation-related stroke

Rongjun Zou, Dingwen Zhang, Lei Lv, Wanting Shi, Zijiao Song, Bin Yi, Bingjia Lai, Qian Chen, Songran Yang, Ping Hua

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients: a Prevalence Study in China

Donghui Yu, Qinglong Deng, Jiwei Wang, Xing Chang, Shuxiao Wang, Renren Yang, Jinming Yu, Jing Yu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High throughput sequencing of T-cell receptor repertoire using dry blood spots

Shang-Gin Wu, Wenjing Pan, Hongna Liu, Miranda L. Byrne-Steele, Brittany Brown, Mollye Depinet, Xiaohong Hou, Jian Han, Song Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Discriminatory ability of anthropometric measurements of central fat distribution for prediction of post-prandial hyperglycaemia in patients with normal fasting glucose: the DICAMANO Study

Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck, Javier Escalada

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Generating randomness: making the most out of disordering a false order into a real one

Yaron Ilan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma

Xiao-Xia Liu, Yi-E Yang, Xiao Liu, Meng-Yu Zhang, Rui Li, Yun-Hong Yin, Yi-Qing Qu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High levels of serum soluble TWEAK are associated with neuroinflammation during multiple sclerosis

Adil Maarouf, Delphine Stephan, Marie-Pierre Ranjeva, Jean-Philippe Ranjeva, Jean Pelletier, Bertrand Audoin, Michel Khrestchatisky, Sophie Desplat-Jégo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Crizotinib with or without an EGFR-TKI in treating EGFR-mutant NSCLC patients with acquired MET amplification after failure of EGFR-TKI therapy: a multicenter retrospective study

Wenxian Wang, Hong Wang, Peihua Lu, Zongyang Yu, Chunwei Xu, Wu Zhuang, Zhengbo Song

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study

Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy, Thomas M. Kinfe

01.12.2019 | Review | Ausgabe 1/2019 Open Access

How mRNA therapeutics are entering the monoclonal antibody field

Lien Van Hoecke, Kenny Roose

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Increased risk of chronic fatigue syndrome in patients with inflammatory bowel disease: a population-based retrospective cohort study

Shin-Yi Tsai, Hsuan-Ju Chen, Chon-Fu Lio, Chien-Feng Kuo, An-Chun Kao, Wei-Shieng Wang, Wei-Cheng Yao, Chi Chen, Tse-Yen Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Jaw osteosarcoma models in mice: first description

Hélios Bertin, Romain Guilho, Régis Brion, Jérôme Amiaud, Séverine Battaglia, Anne Moreau, Anne Brouchet-Gomez, Julie Longis, Benoit Piot, Dominique Heymann, Pierre Corre, Françoise Rédini

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Early and dynamic alterations of Th2/Th1 in previously immunocompetent patients with community-acquired severe sepsis: a prospective observational study

Ming Xue, Jianfeng Xie, Ling Liu, Yingzi Huang, Fengmei Guo, Jingyuan Xu, Yi Yang, Haibo Qiu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comprehensive bioinformatics analysis of acquired progesterone resistance in endometrial cancer cell line

Wenzhi Li, Shufen Wang, Chunping Qiu, Zhiming Liu, Qing Zhou, Deshui Kong, Xiaohong Ma, Jie Jiang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Bioinformatics-based discovery of the urinary BBOX1 mRNA as a potential biomarker of diabetic kidney disease

Le-Ting Zhou, Lin-Li Lv, Shen Qiu, Qing Yin, Zuo-Lin Li, Tao-Tao Tang, Li-Hua Ni, Ye Feng, Bin Wang, Kun-Ling Ma, Bi-Cheng Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia

R. Ellis, M. Katerelos, S. W. Choy, N. Cook, M. Lee, K. Paizis, G. Pell, S. Walker, D. A. Power, P. F. Mount

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study

Fabio Grizzi, Sirio Fiorino, Dorina Qehajaj, Adele Fornelli, Carlo Russo, Dario de Biase, Michele Masetti, Laura Mastrangelo, Matteo Zanello, Raffaele Lombardi, Andrea Domanico, Esterita Accogli, Andrea Tura, Leonardo Mirandola, Maurizio Chiriva-Internati, Robert S. Bresalier, Elio Jovine, Paolo Leandri, Luca Di Tommaso

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway

Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A robust qualitative transcriptional signature for the correct pathological diagnosis of gastric cancer

Haidan Yan, Meifeng Li, Longlong Cao, Haifeng Chen, Hungming Lai, Qingzhou Guan, Huxing Chen, Wenbin Zhou, Baotong Zheng, Zheng Guo, Chaohui Zheng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Adiponectin regulates bone mass in AIS osteopenia via RANKL/OPG and IL6 pathway

Hong-qi Zhang, Long-jie Wang, Shao-hua Liu, Jiong Li, Li-ge Xiao, Guan-teng Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Evaluation of endoscopic visible light spectroscopy: comparison with microvascular oxygen tension measurements in a porcine model

Rinse Ubbink, Louisa J. D. van Dijk, Desirée van Noord, Tanja Johannes, Patricia A. C. Specht, Marco J. Bruno, Egbert G. Mik

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The biological behavior optimization of human periodontal ligament stem cells via preconditioning by the combined application of fibroblast growth factor-2 and A83-01 in in vitro culture expansion

Chunshu Zhang, Hongmei Guo, Chengzhe Yang, Qian Chen, Jiahui Huang, Lianlian Liu, Yu Zhang, Shanshan Jin, Aimei Song, Pishan Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Emerging trends and research foci in gastrointestinal microbiome

Xiaoquan Huang, Xiaowen Fan, Jun Ying, Shiyao Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Processed human amniotic fluid retains its antibacterial activity

Yong Mao, Jan Pierce, Anya Singh-Varma, Michael Boyer, Joachim Kohn, Jo-Anna Reems

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis

Falk Wehrhan, Christian Gross, Kay Creutzburg, Kerstin Amann, Jutta Ries, Marco Kesting, Carol-Immanuel Geppert, Manuel Weber

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of an immune signature predicting prognosis risk of patients in lung adenocarcinoma

Qian Song, Jun Shang, Zuyi Yang, Lanlin Zhang, Chufan Zhang, Jianing Chen, Xianghua Wu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

AntAngioCOOL: computational detection of anti-angiogenic peptides

Javad Zahiri, Babak Khorsand, Ali Akbar Yousefi, Mohammadjavad Kargar, Ramin Shirali Hossein Zade, Ghasem Mahdevar

01.12.2019 | Research | Ausgabe 1/2019 Open Access

TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway

Ya-nan Bie, Peng Gu, Yu-ting Chen, Xiao-xu Zhou, Yu-guang Tian, Qin Yang, Hai-yan Li, Xia Lin, Yan-hong Guan, Tao-yan Lin, Xun Lu, Hong-fen Shen, Ting-xiao Fang, Yu-min Liu, Dong Xiao, Wei-Wang Gu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Chromosome screening using culture medium of embryos fertilised in vitro: a pilot clinical study

Rui Fang, Weimin Yang, Xin Zhao, Fang Xiong, Caiqing Guo, Jianping Xiao, Li Chen, Xiaoqing Song, Honghua Wang, Jie Chen, Xiao Xiao, Bing Yao, Li-Yi Cai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients

M. G. Dal Bello, R. A. Filiberti, A. Alama, A. M. Orengo, M. Mussap, S. Coco, I. Vanni, S. Boccardo, E. Rijavec, C. Genova, F. Biello, G. Barletta, G. Rossi, M. Tagliamento, C. Maggioni, F. Grossi

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

Polyethylene glycol improves current methods for circulating extracellular vesicle-derived DNA isolation

N. García-Romero, R. Madurga, G. Rackov, I. Palacín-Aliana, R. Núñez-Torres, A. Asensi-Puig, J. Carrión-Navarro, S. Esteban-Rubio, H. Peinado, A. González-Neira, V. González-Rumayor, C. Belda-Iniesta, A. Ayuso-Sacido

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway

Wen Su, Shuai Sun, Feng Wang, Yuehong Shen, Hongyu Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Pediatric sleep disturbances and treatment with melatonin

Susanna Esposito, Daniela Laino, Renato D’Alonzo, Annalisa Mencarelli, Lorenza Di Genova, Antonella Fattorusso, Alberto Argentiero, Elisabetta Mencaroni

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Chronic abdominal vagus stimulation increased brain metabolic connectivity, reduced striatal dopamine transporter and increased mid-brain serotonin transporter in obese miniature pigs

Charles-Henri Malbert, Mickael Genissel, Jean-Louis Divoux, Christine Henry

01.12.2019 | Research | Ausgabe 1/2019 Open Access

m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance

João Lobo, Ana Laura Costa, Mariana Cantante, Rita Guimarães, Paula Lopes, Luís Antunes, Isaac Braga, Jorge Oliveira, Mattia Pelizzola, Rui Henrique, Carmen Jerónimo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Diagnostic sensitivity of 2-day cardiopulmonary exercise testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Maximillian J. Nelson, Jonathan D. Buckley, Rebecca L. Thomson, Daniel Clark, Richard Kwiatek, Kade Davison

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Exosome microRNA signatures in patients with complex regional pain syndrome undergoing plasma exchange

Sujay Ramanathan, Sabrina R. Douglas, Guillermo M. Alexander, Botros B. Shenoda, James E. Barrett, Enrique Aradillas, Ahmet Sacan, Seena K. Ajit

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

Production of a cellular product consisting of monocytes stimulated with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for human use

Daniel S. Green, Ana T. Nunes, Kevin W. Tosh, Virginia David-Ocampo, Vicki S. Fellowes, Jiaqiang Ren, Jianjian Jin, Sue-Ellen Frodigh, Chauha Pham, Jolynn Procter, Celina Tran, Irene Ekwede, Hanh Khuu, David F. Stroncek, Steven L. Highfill, Kathryn C. Zoon, Christina M. Annunziata

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?

C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia, N. Di Simone

01.12.2019 | Research | Ausgabe 1/2019 Open Access

RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis

Jooyeon Jhun, Seung Hoon Lee, Se-Young Kim, Jaeyoon Ryu, Ji Ye Kwon, Hyun Sik Na, KyoungAh Jung, Su-Jin Moon, Mi-La Cho, Jun-Ki Min

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Driving the precision medicine highway: community health workers and patient navigators

Irma N. Ramos, Kristie N. Ramos, Kenneth S. Ramos

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He, Hui Xu, C-STRIDE study group

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Vitamin D and growth hormone in children: a review of the current scientific knowledge

Susanna Esposito, Alberto Leonardi, Lucia Lanciotti, Marta Cofini, Giulia Muzi, Laura Penta

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Dermal tissue remodeling and non-osmotic sodium storage in kidney patients

Ryanne S. Hijmans, Marco van Londen, Kwaku A. Sarpong, Stephan J. L. Bakker, Gerjan J. Navis, Twan T. R. Storteboom, Wilhelmina H. A. de Jong, Robert A. Pol, Jacob van den Born

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Design and biomechanical characteristics of porous meniscal implant structures using triply periodic minimal surfaces

Li-ya Zhu, Lan Li, Zong-an Li, Jian-ping Shi, Wen-lai Tang, Ji-quan Yang, Qing Jiang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis

Zibo Li, Yukun Lin, Shuhui Zhang, Lin Zhou, Guixi Yan, Yuehua Wang, Mengdi Zhang, Mengqi Wang, Haihong Lin, Qiaozhen Tong, Yongjian Duan, Gangjun Du

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Hyperoxia-induced lung structure–function relation, vessel rarefaction, and cardiac hypertrophy in an infant rat model

Francesco Greco, Susanne Wiegert, Philipp Baumann, Sven Wellmann, Giovanni Pellegrini, Vincenzo Cannizzaro

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Nuclear shape, architecture and orientation features from H&E images are able to predict recurrence in node-negative gastric adenocarcinoma

Meng-Yao Ji, Lei Yuan, Xiao-Da Jiang, Zhi Zeng, Na Zhan, Ping-Xiao Huang, Cheng Lu, Wei-Guo Dong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Altered PGE2-EP2 is associated with an excessive immune response in HBV-related acute-on-chronic liver failure

Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen, Haihong Zhu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Neural-network analysis of socio-medical data to identify predictors of undiagnosed hepatitis C virus infections in Germany (DETECT)

Markus Reiser, Bianka Wiebner, Jürgen Hirsch, the German Liver Foundation

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes

Concepción Santiago-Fernández, Luis M. Pérez-Belmonte, Mercedes Millán-Gómez, Inmaculada Moreno-Santos, Fernando Carrasco-Chinchilla, Amalio Ruiz-Salas, Luis Morcillo-Hidalgo, José M. Melero, Lourdes Garrido-Sánchez, Manuel Jiménez-Navarro

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors

Niklas Schäfer, Gerrit H. Gielen, Laurèl Rauschenbach, Sied Kebir, Andreas Till, Roman Reinartz, Matthias Simon, Pitt Niehusmann, Christoph Kleinschnitz, Ulrich Herrlinger, Torsten Pietsch, Björn Scheffler, Martin Glas

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Spray drying OZ439 nanoparticles to form stable, water-dispersible powders for oral malaria therapy

Kurt D. Ristroph, Jie Feng, Simon A. McManus, Yingyue Zhang, Kai Gong, Hanu Ramachandruni, Claire E. White, Robert K. Prud’homme

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Development and validation of a prognostic nomogram in gastric cancer with hepatitis B virus infection

Yi He, Minjie Mao, Wenjuan Shi, Zhonglian He, Lin Zhang, Xueping Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A nomogram to predict survival in non-small cell lung cancer patients treated with nivolumab

Andrea Botticelli, Massimiliano Salati, Francesca Romana Di Pietro, Lidia Strigari, Bruna Cerbelli, Ilaria Grazia Zizzari, Raffaele Giusti, Marco Mazzotta, Federica Mazzuca, Michela Roberto, Patrizia Vici, Laura Pizzuti, Marianna Nuti, Paolo Marchetti

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers

Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev, Aladar A. Szalay

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients

Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou, Shan Cao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia

Zi-jun Xu, Ji-chun Ma, Jing-dong Zhou, Xiang-mei Wen, Dong-ming Yao, Wei Zhang, Run-bi Ji, De-hong Wu, Li-juan Tang, Zhao-qun Deng, Jun Qian, Jiang Lin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Crosstalk between tumor cells and lymphocytes modulates heparanase expression

Thérèse Rachell Theodoro, Leandro Luongo Matos, Renan Pelluzzi Cavalheiro, Giselle Zenker Justo, Helena Bonciani Nader, Maria Aparecida Silva Pinhal

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Cartilage progenitor cells combined with PHBV in cartilage tissue engineering

Ke Xue, Xiaodie Zhang, Zixu Gao, Wanyao Xia, Lin Qi, Kai Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Key metabolic parameters change significantly in early breast cancer survivors: an explorative PILOT study

Stine Overvad Fredslund, Claus Højbjerg Gravholt, Britt Elmedal Laursen, Anders Bonde Jensen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High expression of miR-363 predicts poor prognosis and guides treatment selection in acute myeloid leukemia

Huihui Zhang, Ninghan Zhang, Rong Wang, Tingting Shao, Yuan Feng, Yao Yao, Qingyun Wu, Shengyun Zhu, Jiang Cao, Huanxin Zhang, Zhenyu Li, Xuejiao Liu, Mingshan Niu, Kailin Xu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

FNDC5 attenuates obesity-induced cardiac hypertrophy by inactivating JAK2/STAT3-associated inflammation and oxidative stress

Zhi Geng, Wen-Yong Fan, Bing Zhou, Chao Ye, Ying Tong, Ye-Bo Zhou, Xiao-Qing Xiong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

ZCCHC13-mediated induction of human liver cancer is associated with the modulation of DNA methylation and the AKT/ERK signaling pathway

Zhiming Li, Zhi Li, Linjun Wang, Chen Long, Zaozao Zheng, Xuan Zhuang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Somatic mutation of DNAH genes implicated higher chemotherapy response rate in gastric adenocarcinoma patients

Chunchao Zhu, Qin Yang, Jia Xu, Wenyi Zhao, Zizhen Zhang, Danhua Xu, Yeqian Zhang, Enhao Zhao, Gang Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes

Camilla Schumacher-Petersen, Berit Østergaard Christoffersen, Rikke Kaae Kirk, Trine Pagh Ludvigsen, Nora Elisabeth Zois, Henrik Duelund Pedersen, Mogens Vyberg, Lisbeth Høier Olsen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Promoting therapeutic angiogenesis of focal cerebral ischemia using thrombospondin-4 (TSP4) gene-modified bone marrow stromal cells (BMSCs) in a rat model

Qian Zhang, Meiling Zhou, Xiangfeng Wu, Zhu Li, Bing Liu, Wenbin Gao, Jin Yue, Tao Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Monoallelic expression in melanoma

Lee Silcock, Hakeem Almabrazi, Younes Mokrab, Puthen Jithesh, Muna Al-Hashmi, Nicola James, Rebecca Mathew, Valentina Mattei, Davide Bedognetti, Francesca Lessi, Ramzi Temanni, Barbara Seliger, Rashid Al-Ali, Francesco M. Marincola, Ena Wang, Sara Tomei

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Interleukin 32 expression in human melanoma

Helicia Paz, Jennifer Tsoi, Anusha Kalbasi, Catherine S. Grasso, William H. McBride, Dörthe Schaue, Lisa H. Butterfield, Deena M. Maurer, Antoni Ribas, Thomas G. Graeber, James S. Economou

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Are innovation and new technologies in precision medicine paving a new era in patients centric care?

Attila A. Seyhan, Claudio Carini

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Quantitation of progenitor cell populations and growth factors after bone marrow aspirate concentration

Richard Schäfer, Malcolm R. DeBaun, Erika Fleck, Christopher J. Centeno, Daniela Kraft, Johannes Leibacher, Karen Bieback, Erhard Seifried, Jason L. Dragoo

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Analysis of the role of the Hippo pathway in cancer

Yanyan Han

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Pretreatment risk management of a novel nomogram model for prediction of thoracoabdominal extrahepatic metastasis in primary hepatic carcinoma

Jia Hu, Ting Wang, Kun-He Zhang, Yi-Ping Jiang, Song Xu, Si-Hai Chen, Yu-Ting He, Hai-Liang Yuan, Yu-Qi Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clusterin silencing restores myoblasts viability and down modulates the inflammatory process in osteoporotic disease

S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi, U. Tarantino

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comparison and development of machine learning tools in the prediction of chronic kidney disease progression

Jing Xiao, Ruifeng Ding, Xiulin Xu, Haochen Guan, Xinhui Feng, Tao Sun, Sibo Zhu, Zhibin Ye

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Increased CD8+CD28+ T cells independently predict better early response to stereotactic ablative radiotherapy in patients with lung metastases from non-small cell lung cancer

Chao Liu, Qinyong Hu, Kai Hu, Huichao Su, Fang Shi, Li Kong, Hui Zhu, Jinming Yu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Fibroblast growth factor 23, endothelium biomarkers and acute kidney injury in critically-ill patients

Fernanda Macedo de Oliveira Neves, Camila Barbosa Araújo, Daniele Ferreira de Freitas, Bianca Fernandes Távora Arruda, Leonardo José Monteiro de Macêdo Filho, Vivian Brito Salles, Gdayllon Cavalcante Meneses, Alice Maria Costa Martins, Alexandre Braga Libório

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways

Meng Wang, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Li Li, Hui Gao, Zhi Zhao, Fan Zhu, Han Zhu, Wangqun Liang, Kun Qian, Chunxiu Zhang, Rui Zeng, Hanjing Zhou, Ying Yao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia

Wijden Mahfoudh, Inchirah Bettaieb, Randa Ghedira, Kaouther Snoussi, Nadia Bouzid, Zahra Klayech, Sallouha Gabbouj, Yassmine Remadi, Elham Hassen, Noureddine Bouaouina, Abdelfateh Zakhama

01.12.2019 | Research | Ausgabe 1/2019 Open Access

An enrichment method to increase cell-free fetal DNA fraction and significantly reduce false negatives and test failures for non-invasive prenatal screening: a feasibility study

Ping Hu, Dong Liang, Yangyi Chen, Ying Lin, Fengchang Qiao, Hang Li, Ting Wang, Chunfang Peng, Donghong Luo, Hailiang Liu, Zhengfeng Xu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer

Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong, Stanley K. Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Role of MAML1 in targeted therapy against the esophageal cancer stem cells

Meysam Moghbeli, Hooman Mosannen Mozaffari, Bahram Memar, Mohammad Mahdi Forghanifard, Mehran Gholamin, Mohammad Reza Abbaszadegan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation

Alex Ali Sayour, Sevil Korkmaz-Icöz, Sivakkanan Loganathan, Mihály Ruppert, Viktor Nabil Sayour, Attila Oláh, Kálmán Benke, Maik Brune, Rita Benkő, Eszter Mária Horváth, Matthias Karck, Béla Merkely, Tamás Radovits, Gábor Szabó

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production

Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber, Shibani Pati

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Joint bioinformatics analysis of underlying potential functions of hsa-let-7b-5p and core genes in human glioma

Xiaonan Xi, Yahui Chu, Ning Liu, Qianqian Wang, Zheng Yin, Yaxin Lu, Yue Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Effect of chemotherapy on cancer stem cells and tumor-associated macrophages in a prospective study of preoperative chemotherapy in soft tissue sarcoma

Keith M. Skubitz, Jon D. Wilson, Edward Y. Cheng, Bruce R. Lindgren, Kristin L. M. Boylan, Amy P. N. Skubitz

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy

Matteo Pallocca, Davide Angeli, Fabio Palombo, Francesca Sperati, Michele Milella, Frauke Goeman, Francesca De Nicola, Maurizio Fanciulli, Paola Nisticò, Concetta Quintarelli, Gennaro Ciliberto

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies

Wai Hoong Chang, Alvina G. Lai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The French glioblastoma biobank (FGB): a national clinicobiological database

Anne Clavreul, Gwénaëlle Soulard, Jean-Michel Lemée, Marion Rigot, Pascale Fabbro-Peray, Luc Bauchet, Dominique Figarella-Branger, Philippe Menei, FGB network

01.12.2019 | Editorial | Ausgabe 1/2019 Open Access

Journal of Translational Medicine advances in Translational Genomics and Genetics Era

Wei Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

RIPK1 suppresses apoptosis mediated by TNF and caspase-3 in intervertebral discs

Xubin Qiu, Ming Zhuang, Ziwen Lu, Zhiwei Liu, Dong Cheng, Chenlei Zhu, Jinbo Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia–reperfusion injury

Lars Hummitzsch, Karina Zitta, Rouven Berndt, Yuk Lung Wong, Rene Rusch, Katharina Hess, Thilo Wedel, Matthias Gruenewald, Jochen Cremer, Markus Steinfath, Martin Albrecht

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer

Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca, Emanuele Romairone, Gabriele Zoppoli, Alberto Ballestrero

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A 105 kb interstitial insertion in the Xq27.1 palindrome from pseudoautosomal region PAR1 causes a novel X-linked recessive compound phenotype

Nuo Si, Xiaolu Meng, Zhen Zhao, Weibo Xia, Xue Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A circulating miRNA signature for early diagnosis of acute kidney injury following acute myocardial infarction

Pei-Chun Fan, Chia-Chun Chen, Chen-Ching Peng, Chih-Hsiang Chang, Chia-Hung Yang, Chi Yang, Lichieh Julie Chu, Yung-Chang Chen, Chih-Wei Yang, Yu-Sun Chang, Pao-Hsien Chu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Serum GP73 predicts posthepatectomy outcomes in patients with hepatocellular carcinoma

Meng-yun Ke, Xiao-ning Wu, Yao Zhang, Saisai Wang, Yi Lv, Jian Dong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms

Michal Korostynski, Marcin Piechota, Rafal Morga, Dzesika Hoinkis, Slawomir Golda, Magdalena Zygmunt, Tomasz Dziedzic, Marek Moskala, Agnieszka Slowik, Joanna Pera

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Mesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury

Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang, Jianghua Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway

Jing-Qiang Huang, Fa-Kai Wei, Xiu-Li Xu, Shi-Xing Ye, Jun-Wei Song, Pei-Kun Ding, Jing Zhu, He-Feng Li, Xin-Ping Luo, Hui Gong, Li Su, Lin Yang, Li-Yun Gong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Distribution and functions of γδ T cells infiltrated in the ovarian cancer microenvironment

Xian Chen, Wenwen Shang, Rui Xu, Ming Wu, Xiaojie Zhang, Peijun Huang, Fang Wang, Shiyang Pan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Blood cell transcript levels in 5-year-old children as potential markers of breastfeeding effects in those small for gestational age at birth

Julio Alvarez-Pitti, Maria Amparo Ros-Forés, Ana Bayo-Pérez, Mariona Palou, Empar Lurbe, Andreu Palou, Catalina Picó

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Development and validation of a risk prediction score for severe acute pancreatitis

Wandong Hong, Keith D. Lillemoe, Shuang Pan, Vincent Zimmer, Evangelos Kontopantelis, Simon Stock, Maddalena Zippi, Chao Wang, Mengtao Zhou

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Interferon gamma induces inflammatory responses through the interaction of CEACAM1 and PI3K in airway epithelial cells

Yichun Zhu, Dongli Song, Yuanlin Song, Xiangdong Wang

01.12.2019 | Meeting report | Ausgabe 1/2019 Open Access

The great debate at “Melanoma Bridge 2018”, Naples, December 1st, 2018

Paolo A. Ascierto, Paolo Bruzzi, Alexander Eggermont, Omid Hamid, Hussein A. Tawbi, Alexander van Akkooi, Alessandro Testori, Corrado Caracò, Igor Puzanov, Francesco Perrone

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Low expression of ACLY associates with favorable prognosis in acute myeloid leukemia

Jinghan Wang, Wenle Ye, Xiao Yan, Qi Guo, Qiuling Ma, Fang Lin, Jiansong Huang, Jie Jin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A world map of esophagus cancer research: a critical accounting

Doris Klingelhöfer, Yun Zhu, Markus Braun, Dörthe Brüggmann, Norman Schöffel, David A. Groneberg

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Ya-Chao Tao, Meng-Lan Wang, Dong-Bo Wu, Chen Luo, Hong Tang, En-Qiang Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A robust six-gene prognostic signature for prediction of both disease-free and overall survival in non-small cell lung cancer

Shuguang Zuo, Min Wei, Hailin Zhang, Anxian Chen, Junhua Wu, Jiwu Wei, Jie Dong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

miRNA deregulation targets specific pathways in leiomyosarcoma development: an in silico analysis

Clara Benna, Senthilkumar Rajendran, Marco Rastrelli, Simone Mocellin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study

Shin-Yi Tsai, Hsuan-Ju Chen, Chi Chen, Chon-Fu Lio, Chien-Feng Kuo, Kam-Hang Leong, Yu-Ting Tina Wang, Tse-Yen Yang, Ching-Hui You, Wei-Sheng Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

-Omics biomarker identification pipeline for translational medicine

Laura Bravo-Merodio, John A. Williams, Georgios V. Gkoutos, Animesh Acharjee

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A microarray-based pathogen chip for simultaneous molecular detection of transfusion–transmitted infectious agents

Valeria De Giorgi, Huizhi Zhou, Harvey J. Alter, Robert D. Allison

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A possible role for mitochondrial-derived peptides humanin and MOTS-c in patients with Q fever fatigue syndrome and chronic fatigue syndrome

Ruud P. H. Raijmakers, Anne F. M. Jansen, Stephan P. Keijmel, Rob ter Horst, Megan E. Roerink, Boris Novakovic, Leo A. B. Joosten, Jos W. M. van der Meer, Mihai G. Netea, Chantal P. Bleeker-Rovers

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation

Dongli Song, Menglin Xu, Ruixue Qi, Ruihua Ma, Yile Zhou, Duojiao Wu, Hao Fang, Xiangdong Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Multicellular gene network analysis identifies a macrophage-related gene signature predictive of therapeutic response and prognosis of gliomas

Xiaoqiang Sun, Xiaoping Liu, Mengxue Xia, Yongzhao Shao, Xiaohua Douglas Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Hemodynamic impacts of flow diverter devices on the ophthalmic artery

Xinzhi Wu, Zhongbin Tian, Jian Liu, Wenqiang Li, Junfan Chen, Yangyang Zhou, Xinjian Yang, Shiqing Mu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

AIBP and APOA-I synergistically inhibit intestinal tumor growth and metastasis by promoting cholesterol efflux

Tao Zhang, Qilong Wang, Yeqi Wang, Junping Wang, Yongping Su, Fengchao Wang, Guixue Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Values of integration between lipidomics and clinical phenomes in patients with acute lung infection, pulmonary embolism, or acute exacerbation of chronic pulmonary diseases: a preliminary study

Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang, Xiangdong Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts, Ashok Saluja

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Predicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model

Sen Cheng, Jiaqi Wu, Chuzhong Li, Yangfang Li, Chunhui Liu, Guilin Li, Wuju Li, Shuofeng Hu, Xiaomin Ying, Yazhuo Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

TNF-α-induced Tim-3 expression marks the dysfunction of infiltrating natural killer cells in human esophageal cancer

Yujia Zheng, Yu Li, Jingyao Lian, Huiyun Yang, Feng Li, Song Zhao, Yu Qi, Yi Zhang, Lan Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia

Ying Song, Weilong Zhang, Xue He, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Hongmei Jing, Xiaoliang Yuan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Reduced eIF3d accelerates HIV disease progression by attenuating CD8+ T cell function

Ying Pan, Zi-Ning Zhang, Lin-Bo Yin, Ya-Jing Fu, Yong-Jun Jiang, Hong Shang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis

Yi Li, Shumei Yang, Zhibin Li, Huanyu Meng, Wanling Jin, Huan Yang, Weifan Yin

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Why primary obesity is a disease?

Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci, Laura Di Renzo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

ALS blood expression profiling identifies new biomarkers, patient subgroups, and evidence for neutrophilia and hypoxia

William R. Swindell, Colin P. S. Kruse, Edward O. List, Darlene E. Berryman, John J. Kopchick

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Computational models for the prediction of adverse cardiovascular drug reactions

Salma Jamal, Waseem Ali, Priya Nagpal, Sonam Grover, Abhinav Grover

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Biobanking in health care: evolution and future directions

Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli, Marco Salvatore

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy

C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He, S. K. Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Plasma therapy leads to an increase in functional IgA and IgM concentration in the blood and saliva of a patient with X-linked agammaglobulinemia

Jeroen D. Langereis, Joannes F. M. Jacobs, Marien I. de Jonge, Marcel van Deuren

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Virus-like vaccines against HIV/SIV synergize with a subdominant antigen T cell vaccine

Melanie Schwerdtfeger, Anne-Marie Carola Andersson, Lasse Neukirch, Peter Johannes Holst

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction

Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh, Mark O. Goodarzi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comprehensive characterization of immune- and inflammation-associated biomarkers based on multi-omics integration in kidney renal clear cell carcinoma

Enyang Zhao, Lihong Li, Wenfu Zhang, Wanhui Wang, Yunhui Chan, Bosen You, Xuedong Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic value of TIM-1 expression in human non-small-cell lung cancer

Xiao Zheng, Kai Xu, Lujun Chen, You Zhou, Jingting Jiang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Integrated analysis of 34 microarray datasets reveals CBX3 as a diagnostic and prognostic biomarker in glioblastoma

Siqi Wang, Fang Liu, Yuhui Wang, Wenliang Fan, Hongyang Zhao, Liying Liu, Chunyuan Cen, Xiaobin Jiang, Min Sun, Ping Han

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Time-of-day at symptom onset was not associated with infarct size and long-term prognosis in patients with ST-segment elevation myocardial infarction

Hendrik B. Sager, Oliver Husser, Sabine Steffens, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati, Gjin Ndrepepa, Thorsten Kessler

01.12.2019 | Research | Ausgabe 1/2019 Open Access

E2F1 germline copy number variations and melanoma susceptibility

Maria Santa Rocca, Clara Benna, Simone Mocellin, Carlo Riccardo Rossi, Aichi Msaki, Andrea Di Nisio, Giuseppe Opocher, Carlo Foresta

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The volumetric-tumour histogram-based analysis of intravoxel incoherent motion and non-Gaussian diffusion MRI: association with prognostic factors in HER2-positive breast cancer

Chao You, Jianwei Li, Wenxiang Zhi, Yanqiong Chen, Wentao Yang, Yajia Gu, Weijun Peng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Intestinal injury and gut permeability in sickle cell disease

Dibyendu Dutta, Barbara Methe, Salomon Amar, Alison Morris, Seah H. Lim

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinical biomarker discovery by SWATH-MS based label-free quantitative proteomics: impact of criteria for identification of differentiators and data normalization method

Mythreyi Narasimhan, Sadhana Kannan, Aakash Chawade, Atanu Bhattacharjee, Rukmini Govekar

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Orthostatic intolerance in chronic fatigue syndrome

Richard Garner, James N. Baraniuk

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of two microRNA signatures in whole blood as novel biomarkers for diagnosis of nasopharyngeal carcinoma

Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang, Ling Guo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Molecular profiling of microinvasive breast cancer microenvironment progression

F. Lessi, C. Scatena, P. Aretini, M. Menicagli, S. Franceschi, A. G. Naccarato, C. M. Mazzanti

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CEBPE expression is an independent prognostic factor for acute myeloid leukemia

Kening Li, Yuxin Du, Dong-Qing Wei, Fang Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing

Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang, Liang Shang, Shouxin Wu, Peng Meng, Ling Lin, Jiangman Zhao, Mingming Nie, Kai Yin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia

Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao, Dan Hu, Shengqing Gu, Huiyu Li, Anyuan Guo, Shiang Huang, Xiaolan Feng, Dong Hu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Regulatory T cells and M2 macrophages present diverse prognostic value in gastric cancer patients with different clinicopathologic characteristics and chemotherapy strategies

Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao, Gang Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Novel nomograms to predict lymph node metastasis and liver metastasis in patients with early colon carcinoma

Yongcong Yan, Haohan Liu, Kai Mao, Mengyu Zhang, Qianlei Zhou, Wei Yu, Bingchao Shi, Jie Wang, Zhiyu Xiao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Akt-activated endothelium promotes ovarian cancer proliferation through notch activation

Jessica Hoarau-Véchot, Cyril Touboul, Najeeb Halabi, Morgane Blot-Dupin, Raphael Lis, Charbel Abi Khalil, Shahin Rafii, Arash Rafii, Jennifer Pasquier

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine

Ho Joong Choi, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Ha-Eun Hong, Sang Chul Lee, Kee-Hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho Hong, Eun Young Kim, Jung Hyun Park, Gun Hyung Na, Dong Do You, Jae Hyun Han, Jae Woo Park, Bong Jun Kwak, Tae Yun Lee, Joseph Ahn, Hwan Hee Lee, Seung Kyu Kang, Kyu-Seok Hwang, Jae-Kyung Jung, Kwan-Young Jung, Say-June Kim

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Cytokine expression in Treponema pallidum infection

N. Kojima, J. C. Siebert, H. Maecker, Y. Rosenberg-Hasson, S. R. Leon, S. K. Vargas, K. A. Konda, C. F. Caceres, J. D. Klausner

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis

Luo-Yi Wang, Xiao-Jing Sun, Min Chen, Ming-Hui Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Discriminant analysis and machine learning approach for evaluating and improving the performance of immunohistochemical algorithms for COO classification of DLBCL

Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza, Luis Villela

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer

Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto, Markus J. Mäkinen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Translational formulation of nanoparticle therapeutics from laboratory discovery to clinical scale

Jie Feng, Chester E. Markwalter, Chang Tian, Madeleine Armstrong, Robert K. Prud’homme

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Stapled EGFR peptide reduces inflammatory breast cancer and inhibits additional HER-driven models of cancer

Sabrina A. Maisel, Derrick Broka, Benjamin Atwell, Thomas Bunch, Robert Kupp, Shiv K. Singh, Shwetal Mehta, Joyce Schroeder

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mediation of the effect of serum uric acid on the risk of developing hypertension: a population-based cohort study

Zhi Cao, Yangyang Cheng, Shu Li, Hongxi Yang, Li Sun, Ying Gao, Pei Yu, Weidong Li, Yaogang Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Development and validation of a new tumor-based gene signature predicting prognosis of HBV/HCV-included resected hepatocellular carcinoma patients

Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu, Zhi Dai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Development of a novel ssDNA aptamer targeting neutrophil gelatinase-associated lipocalin and its application in clinical trials

Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu, Xiaopeng Lan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling

Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry, Sajjad Muhammad

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A mixed-methods evaluation of a community physical activity program for breast cancer survivors

Catherine M. Sabiston, Angela J. Fong, Erin K. O’Loughlin, Sarkis Meterissian

01.12.2019 | Research | Ausgabe 1/2019 Open Access

PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma

Yui Hirata-Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis, Hiroya Kobayashi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer

Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu, Eva Colas

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Risk factors for the occurrence of visual-threatening posterior capsule opacification

Hung-Chi Chen, Chia-Yi Lee, Chi-Chin Sun, Jing-Yang Huang, Hung-Yu Lin, Shun-Fa Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

ARL3 is downregulated and acts as a prognostic biomarker in glioma

Yulin Wang, Weijiang Zhao, Xin Liu, Gefei Guan, Minghua Zhuang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells regulate inflammation and enhance tendon healing

Zhengzhou Shi, Qi Wang, Dapeng Jiang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins

Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz, Samir Boubaker

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The clinical value of cytokines in chronic fatigue syndrome

Tiansong Yang, Yan Yang, Delong Wang, Chaoran Li, Yuanyuan Qu, Jing Guo, Tianyu Shi, Wang Bo, Zhongren Sun, Tetsuya Asakawa

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

Chuan Qin, Xin-Ling Zhao, Xiao-Tong Ma, Luo-Qi Zhou, Long-jun Wu, Ke Shang, Wei Wang, Dai-Shi Tian

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of novel inhibitors for TNFα, TNFR1 and TNFα-TNFR1 complex using pharmacophore-based approaches

Madhu Sudhana Saddala, Hu Huang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma

Md Zahidul I. Pranjol, Dmitry A. Zinovkin, Annelie R. T. Maskell, Laura J. Stephens, Sergey L. Achinovich, Dmitry M. Los’, Eldar A. Nadyrov, Michael Hannemann, Nicholas J. Gutowski, Jacqueline L. Whatmore

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification and validation of an immune cell infiltrating score predicting survival in patients with lung adenocarcinoma

Xiaodong Yang, Yu Shi, Ming Li, Tao Lu, Junjie Xi, Zongwu Lin, Wei Jiang, Weigang Guo, Cheng Zhan, Qun Wang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Genetic and molecular biology of breast cancer among Iranian patients

Meysam Moghbeli

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4+CD25+Foxp3+ and CD4+CD25−Foxp3+ T cells

Magdalena J. Polanczyk, Edwin Walker, Daniel Haley, Bella S. Guerrouahen, Emmanuel T. Akporiaye

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients

Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng, Xiao-Ping Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Efficacy and safety of stem cell therapy in patients with dilated cardiomyopathy: a systematic appraisal and meta-analysis

Shu-Ling Rong, Ze-Kun Wang, Xue-Dong Zhou, Xiao-Lin Wang, Zhi-Ming Yang, Bao Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes

Sergio Martínez-Hervás, Verónica Sánchez-García, Andrea Herrero-Cervera, Ángela Vinué, José Tomás Real, Juan F. Ascaso, Deborah Jane Burks, Herminia González-Navarro

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Animal to human translation: a systematic scoping review of reported concordance rates

Cathalijn H. C. Leenaars, Carien Kouwenaar, Frans R. Stafleu, André Bleich, Merel Ritskes-Hoitinga, Rob B. M. De Vries, Franck L. B. Meijboom

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone

Jing Song, Weini Ma, Xinyi Gu, Le Zhao, Jiaye Jiang, Ying Xu, Lei Zhang, Mingmei Zhou, Li Yang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Smoking and microbiome in oral, airway, gut and some systemic diseases

Chunrong Huang, Guochao Shi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinicohistopathological implications of MMP/VEGF expression in retinoblastoma: a combined meta-analysis and bioinformatics analysis

Jingyi Zhu, Xi Zhang, Liqianyu Ai, Rongdi Yuan, Jian Ye

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Personalizing the safe, appropriate and effective concentration(s) of ozone for a non-diabetic individual and four type II diabetic patients in autohemotherapy through blood hemoglobin analysis

Fouad Mehraban, Arefeh Seyedarabi, Shahin Ahmadian, Vahid Mirzaaghaei, Ali Akbar Moosavi-Movahedi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Dysbiosis of the gut microbiome is associated with CKD5 and correlated with clinical indices of the disease: a case–controlled study

Yang Li, Xinhuan Su, Lei Zhang, Yanwei Liu, Min Shi, Chenxiao Lv, Ying Gao, Dongmei Xu, Zunsong Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy

Mária Lódi, Dániel Priksz, Gábor Áron Fülöp, Beáta Bódi, Alexandra Gyöngyösi, Lilla Nagy, Árpád Kovács, Attila Béla Kertész, Judit Kocsis, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, Béla Juhász, István Lekli, Péter Bai, Attila Tóth, Zoltán Papp, Dániel Czuriga

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tumor-derived exosomes promote the in vitro osteotropism of melanoma cells by activating the SDF-1/CXCR4/CXCR7 axis

Francesco Mannavola, Marco Tucci, Claudia Felici, Anna Passarelli, Stella D’Oronzo, Francesco Silvestris

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Revealing the pathogenic changes of PAH based on multiomics characteristics

Li Zhang, Shaokun Chen, Xixi Zeng, Dacen Lin, Yumei Li, Longxin Gui, Mo-jun Lin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs

Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss, Robert J. Freishtat

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Detection of lymph node metastasis in lung cancer patients using a one-step nucleic acid amplification assay: a single-centre prospective study

María Escalante Pérez, María Teresa Hermida Romero, Begoña Otero Alén, Mónica Álvarez Martínez, Ricardo Fernández Prado, Mercedes de la Torre Bravos, Ángel Concha López

01.12.2019 | Meeting report | Ausgabe 1/2019 Open Access

Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th–1 December 1st, 2018, Naples, Italy)

Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giuseppe Palmieri, Laurence Zitvogel, Francesco M. Marincola, Giuseppe Masucci, Corrado Caracò, Magdalena Thurin, Igor Puzanov

01.12.2019 | Research | Ausgabe 1/2019 Open Access

PCR-based zebrafish model for personalised medicine in head and neck cancer

Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman, Tuula Salo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The circulating exosomal microRNAs related to albuminuria in patients with diabetic nephropathy

Hyoungnae Kim, Yun-Ui Bae, Jin Seok Jeon, Hyunjin Noh, Hyeong Kyu Park, Dong Won Byun, Dong Cheol Han, Seongho Ryu, Soon Hyo Kwon

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Purple corn extract induces long-lasting reprogramming and M2 phenotypic switch of adipose tissue macrophages in obese mice

Federica Tomay, Alessandra Marinelli, Valerio Leoni, Claudio Caccia, Andrea Matros, Hans-Peter Mock, Chiara Tonelli, Katia Petroni

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Wolfram syndrome, a rare neurodegenerative disease: from pathogenesis to future treatment perspectives

Maria Teresa Pallotta, Giorgia Tascini, Roberta Crispoldi, Ciriana Orabona, Giada Mondanelli, Ursula Grohmann, Susanna Esposito

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy

Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours, Guy Jerusalem

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A strategy to protect off-the-shelf cell therapy products using virus-specific T-cells engineered to eliminate alloreactive T-cells

David H. Quach, Luis Becerra-Dominguez, Rayne H. Rouce, Cliona M. Rooney

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Preparing for cell culture scale-out: establishing parity of bioreactor- and flask-expanded mesenchymal stromal cell cultures

Ruud Das, Rens Roosloot, Melissa van Pel, Koen Schepers, Marijn Driessen, Willem E. Fibbe, Joost Dick de Bruijn, Helene Roelofs

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice

Patrick Tjok Joe, Ioanna Christopoulou, Lien van Hoecke, Bert Schepens, Tine Ysenbaert, Carlo Heirman, Kris Thielemans, Xavier Saelens, Joeri L. Aerts

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Impact of probiotics on pathogen survival in an innovative human plasma biofilm model (hpBIOM)

M. Besser, J. Terberger, L. Weber, B. Ghebremedhin, E. A. Naumova, W. H. Arnold, E. K. Stuermer

01.12.2019 | Research | Ausgabe 1/2019 Open Access

European mitochondrial haplogroups predict liver-related outcomes in patients coinfected with HIV and HCV: a retrospective study

Teresa Aldámiz-Echevarría, Salvador Resino, José M. Bellón, María A. Jiménez-Sousa, Pilar Miralles, Luz M. Medrano, Ana Carrero, Cristina Díez, Leire Pérez-Latorre, Chiara Fanciulli, Pilar Garcia-Broncano, Juan Berenguer

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo, Yan Kong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Loss of the PTCH1 tumor suppressor defines a new subset of plexiform fibromyxoma

Sudeep Banerjee, Christopher L. Corless, Markku M. Miettinen, Sangkyu Noh, Rowan Ustoy, Jessica L. Davis, Chih-Min Tang, Mayra Yebra, Adam M. Burgoyne, Jason K. Sicklick

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The epigenome as a putative target for skin repair: the HDAC inhibitor Trichostatin A modulates myeloid progenitor plasticity and behavior and improves wound healing

Mariana Cabanel, Thayse Pinheiro da Costa, Marcia Cury EL-Cheikh, Katia Carneiro

01.12.2019 | Research | Ausgabe 1/2019 Open Access

In vivo model of human post-traumatic heterotopic ossification demonstrates early fibroproliferative signature

Jaira F. de Vasconcellos, Sonia Zicari, Stephen D. Fernicola, Daniel W. Griffin, Youngmi Ji, Emily H. Shin, Patrick Jones, Gregory T. Christopherson, Husain Bharmal, Carl Cirino, Thao Nguyen, Astor Robertson, Vincent D. Pellegrini Jr., Leon J. Nesti

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Novel method for simultaneously detecting HPA and HLA antibodies using Luminex microbeads

Sudan Tao, Shu Chen, Xiaozhen Hong, Ji He, Faming Zhu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function

Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Viganò, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Sollazzo, Antonio Curti, Mario Arpinati, Gaetano La Manna, Matteo Cescon, Antonio Daniele Pinna, Claudio Franceschi, Manuela Battaglia, Rosaria Giordano, Lucia Catani, Roberto Massimo Lemoli

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mesenchymal stem cells promote type 2 macrophage polarization to ameliorate the myocardial injury caused by diabetic cardiomyopathy

Liyuan Jin, Zihui Deng, Jinying Zhang, Chen Yang, Jiejie Liu, Weidong Han, Ping Ye, Yiling Si, Guanghui Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A methodology for deriving the sensitivity of pooled testing, based on viral load progression and pooling dilution

Ngoc T. Nguyen, Hrayer Aprahamian, Ebru K. Bish, Douglas R. Bish

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer

Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu, Yi Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data

Yanjun Xu, Qun Dong, Feng Li, Yingqi Xu, Congxue Hu, Jingwen Wang, Desi Shang, Xuan Zheng, Haixiu Yang, Chunlong Zhang, Mengting Shao, Mohan Meng, Zhiying Xiong, Xia Li, Yunpeng Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats

Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu, Ye-Bo Zhou

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer

Shirong Zhang, Xiaochen Zhang, Wei Lei, Jiafeng Liang, Yasi Xu, Hailiang Liu, Shenglin Ma

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Large-scale expansion and characterization of CD3+ T-cells in the Quantum® Cell Expansion System

Claire Coeshott, Boah Vang, Mark Jones, Brian Nankervis

01.12.2019 | Research | Ausgabe 1/2019 Open Access

SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway

Wenjing Zhu, Jumin Niu, Miao He, Liwen Zhang, Xuemei Lv, Fangxiao Liu, Longyang Jiang, Jing Zhang, Zhaojin Yu, Lin Zhao, Jia Bi, Yuanyuan Yan, Qian Wei, Hong Huo, Yue Fan, Yuzong Chen, Jian Ding, Minjie Wei

01.12.2019 | Research | Ausgabe 1/2019 Open Access

MLMDA: a machine learning approach to predict and validate MicroRNA–disease associations by integrating of heterogenous information sources

Kai Zheng, Zhu-Hong You, Lei Wang, Yong Zhou, Li-Ping Li, Zheng-Wei Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

In vivo efficacy of endothelial growth medium stimulated mesenchymal stem cells derived from patients with critical limb ischemia

Rida Al-Rifai, Philippe Nguyen, Nicole Bouland, Christine Terryn, Lukshe Kanagaratnam, Gaël Poitevin, Caroline François, Catherine Boisson-Vidal, Marie-Antoinette Sevestre, Claire Tournois

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Eosinophilic esophagitis in children: doubts and future perspectives

Elena Cavalli, Andrea Brusaferro, Elena Sofia Pieri, Rita Cozzali, Edoardo Farinelli, Gian Luigi de’ Angelis, Susanna Esposito

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Kinetics of MSC-based enzyme therapy for immunoregulation

Alexandra Burr, Biju Parekkadan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The analysis of risk factors for diabetic nephropathy progression and the construction of a prognostic database for chronic kidney diseases

Gang Wang, Jian Ouyang, Shen Li, Hui Wang, Baofeng Lian, Zhihong Liu, Lu Xie

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Renal temperature reduction progressively favors mitochondrial ROS production over respiration in hypothermic kidney preservation

Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning, Henri G. D. Leuvenink

01.12.2019 | Review | Ausgabe 1/2019 Open Access

New paradigm for stage III melanoma: from surgery to adjuvant treatment

Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli, Corrado Caracò

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The evolving role of genetic tests in reproductive medicine

Federica Cariati, Valeria D’Argenio, Rossella Tomaiuolo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

B7-H3 participates in human salivary gland epithelial cells apoptosis through NF-κB pathway in primary Sjögren’s syndrome

Ping Li, Ying Yang, Yi Jin, Rui Zhao, Chen Dong, Wenjie Zheng, Tianyi Zhang, Jing Li, Zhifeng Gu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Overinterpretation of high throughput sequencing data in medical genetics: first evidence against TMPRSS3/GJB2 digenic inheritance of hearing loss

Monika Ołdak, Urszula Lechowicz, Agnieszka Pollak, Dominika Oziębło, Henryk Skarżyński

01.12.2019 | Research | Ausgabe 1/2019 Open Access

miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis

Xiaolong Du, Lei Hong, Lili Sun, Hongfei Sang, Aiming Qian, Wendong Li, Hao Zhuang, Huoqi Liang, Dandan Song, Chenglong Li, Wenbin Wang, Xiaoqiang Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells

Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield, Aladar A. Szalay

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Recurrent circadian fasting (RCF) improves blood pressure, biomarkers of cardiometabolic risk and regulates inflammation in men

Iftikhar Alam, Rahmat Gul, Joni Chong, Crystal Tze Ying Tan, Hui Xian Chin, Glenn Wong, Radhouene Doggui, Anis Larbi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma

Yu Jin, Wai Yeow Lee, Soo Ting Toh, Chandana Tennakoon, Han Chong Toh, Pierce Kah-Hoe Chow, Alexander Y.-F. Chung, Samuel S. Chong, London L.-P.-J. Ooi, Wing-Kin Sung, Caroline G.-L. Lee

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation

Kisoo Pahk, Hyojin Noh, Chanmin Joung, Mi Jang, Hwa Young Song, Kyung Won Kim, Kihoon Han, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Annexin A8 can serve as potential prognostic biomarker and therapeutic target for ovarian cancer: based on the comprehensive analysis of Annexins

Rui Gou, Liancheng Zhu, Mingjun Zheng, Qian Guo, Yuexin Hu, Xiao Li, Juanjuan Liu, Bei Lin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CDK4/6 inhibitor palbociclib suppresses IgE-mediated mast cell activation

Yi-Bo Hou, Kunmei Ji, Yue-Tong Sun, Li-Na Zhang, Jia-Jie Chen

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Xiaobo Gao, Shun Guo, Song Zhang, An Liu, Lei Shi, Yan Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Kidney injury in response to crystallization of calcium oxalate leads to rearrangement of the intrarenal T cell receptor delta immune repertoire

Chao Zhu, Qing Liang, Yaqun Liu, Deliang Kong, Jie Zhang, Hu Wang, Kejia Wang, Zhiyong Guo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Administration of losartan preserves cardiomyocyte size and prevents myocardial dysfunction in tail-suspended mice by inhibiting p47phox phosphorylation, NADPH oxidase activation and MuRF1 expression

Liwen Liang, Wenyi Yuan, Lina Qu, Huili Li, Lulu Zhang, Guo-Chang Fan, Tianqing Peng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis

Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao, Yu Peng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognosis of clear cell renal cell carcinoma (ccRCC) based on a six-lncRNA-based risk score: an investigation based on RNA-sequencing data

Jiang-hui Zeng, Wei Lu, Liang Liang, Gang Chen, Hui-hua Lan, Xiu-Yun Liang, Xu Zhu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?

Esther Bartholomeus, Nicolas De Neuter, Annelies Lemay, Luc Pattyn, David Tuerlinckx, David Weynants, Koen Van Lede, Gerlant van Berlaer, Dominique Bulckaert, Tine Boiy, Ann Vander Auwera, Marc Raes, Dimitri Van der Linden, Helene Verhelst, Susanne Van Steijn, Tijl Jonckheer, Joke Dehoorne, Rik Joos, Hilde Jansens, Arvid Suls, Pierre Van Damme, Kris Laukens, Geert Mortier, Pieter Meysman, Benson Ogunjimi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Determining the prognostic significance of alternative splicing events in soft tissue sarcoma using data from The Cancer Genome Atlas

Xia Yang, Wen-ting Huang, Rong-quan He, Jie Ma, Peng Lin, Zu-cheng Xie, Fu-chao Ma, Gang Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A randomized, placebo-controlled, double-blinded, single-centre, phase IV trial to assess the efficacy and safety of OM-85 in children suffering from recurrent respiratory tract infections

Susanna Esposito, Sonia Bianchini, Samantha Bosis, Claudia Tagliabue, Ilaria Coro, Alberto Argentiero, Nicola Principi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Diabetogenic effect of pravastatin is associated with insulin resistance and myotoxicity in hypercholesterolemic mice

Estela Lorza-Gil, Marta García-Arevalo, Bianca Cristine Favero, Maria Cristina C. Gomes-Marcondes, Helena C. F. Oliveira

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Herpes simplex virus-1 (HSV-1) infection induces a potent but ineffective IFN-λ production in immune cells of AD and PD patients

Francesca La Rosa, Simone Agostini, Anna Bianchi, Raffaello Nemni, Federica Piancone, Ivana Marventano, Roberta Mancuso, Marina Saresella, Mario Clerici

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Influence of androgenic blockade with flutamide on pain behaviour and expression of the genes that encode the NaV1.7 and NaV1.8 voltage-dependent sodium channels in a rat model of postoperative pain

José Osvaldo Barbosa Neto, João Batista Santos Garcia, Maria do Socorro de Souza Cartágenes, Andressa Godoy Amaral, Luiz Fernando Onuchic, Hazem Adel Ashmawi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Expression of proteins related to autotaxin–lysophosphatidate signaling in thyroid tumors

Eunah Shin, Ja Seung Koo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach

Antonella Manca, Panagiotis Paliogiannis, Maria Colombino, Milena Casula, Amelia Lissia, Gerardo Botti, Corrado Caracò, Paolo A. Ascierto, Maria Cristina Sini, Grazia Palomba, Marina Pisano, Valentina Doneddu, Antonio Cossu, Giuseppe Palmieri, Melanoma Unit of Sassari (MUS), Italian Association for Cancer Research (AIRC) Study Group, for the Italian Melanoma Intergroup (IMI)

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Perrault syndrome with neurological features in a compound heterozygote for two TWNK mutations: overlap of TWNK-related recessive disorders

María Domínguez-Ruiz, Alberto García-Martínez, Marc Corral-Juan, Ángel I. Pérez-Álvarez, Ana M. Plasencia, Manuela Villamar, Miguel A. Moreno-Pelayo, Antoni Matilla-Dueñas, Manuel Menéndez-González, Ignacio del Castillo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets

Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu, Yazhuo Zhang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Incidence and risk factors of early HCC occurrence in HCV patients treated with direct acting antivirals: a prospective multicentre study

Luca Rinaldi, Alessandro Perrella, Maria Guarino, Massimo De Luca, Guido Piai, Nicola Coppola, Pia Clara Pafundi, Fortunato Ciardiello, Morena Fasano, Erika Martinelli, Giovanna Valente, Riccardo Nevola, Caterina Monari, Lucia Miglioresi, Barbara Guerrera, Massimiliano Berretta, Ferdinando Carlo Sasso, Filomena Morisco, Antonio Izzi, Luigi Elio Adinolfi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy

Alba Mangas-Losada, Raquel García-García, Paola Leone, María Pilar Ballester, Andrea Cabrera-Pastor, Amparo Urios, Juan-José Gallego, Juan-José Martínez-Pretel, Carla Giménez-Garzó, Fernando Revert, Desamparados Escudero-García, Joan Tosca, María Pilar Ríos, Cristina Montón, Lucia Durbán, Luis Aparicio, Carmina Montoliu, Vicente Felipo

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating tumor cells as a response monitor in stage IV non-small cell lung cancer

Stephanie N. Shishido, Anders Carlsson, Jorge Nieva, Kelly Bethel, James B. Hicks, Lyudmila Bazhenova, Peter Kuhn

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury

Janet Lee, Hyosun Jang, Sunhoo Park, Hyunwook Myung, Kyuchang Kim, Hyewon Kim, Won-Suk Jang, Sun-Joo Lee, Jae Kyung Myung, Sehwan Shim

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Second line therapy with axitinib after only prior sunitinib in metastatic renal cell cancer: Italian multicenter real world SAX study final results

Gaetano Facchini, Sabrina Rossetti, Massimiliano Berretta, Carla Cavaliere, Sarah Scagliarini, Maria Giuseppa Vitale, Chiara Ciccarese, Giuseppe Di Lorenzo, Erica Palesandro, Vincenza Conteduca, Umberto Basso, Emanuele Naglieri, Azzurra Farnesi, Michele Aieta, Nicolò Borsellino, Leonardo La Torre, Gelsomina Iovane, Lucia Bonomi, Donatello Gasparro, Enrico Ricevuto, Michele De Tursi, Rocco De Vivo, Giovanni Lo Re, Francesco Grillone, Paolo Marchetti, Ferdinando De Vita, Claudio Scavelli, Claudio Sini, Salvatore Pisconti, Anna Crispo, Vittorio Gebbia, Antonio Maestri, Luca Galli, Ugo De Giorgi, Roberto Iacovelli, Carlo Buonerba, Giacomo Cartenì, Carmine D’Aniello

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Cryopreserved mesenchymal stem cells regain functional potency following a 24-h acclimation period

Ben Antebi, Amber M. Asher, Luis A. Rodriguez II, Robbie K. Moore, Arezoo Mohammadipoor, Leopoldo C. Cancio

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The association between BRAF mutation class and clinical features in BRAF-mutant Chinese non-small cell lung cancer patients

Quan Lin, Haoran Zhang, Huaxin Ding, Jun Qian, Analyn Lizaso, Jing Lin, Han Han-Zhang, Jianxing Xiang, Yuping Li, Hong Zhu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Integration analysis for novel lncRNA markers predicting tumor recurrence in human colon adenocarcinoma

Fangyao Chen, Zhe Li, Changyu Deng, Hong Yan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang, Qiang Shu

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts, Ashok Saluja

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma

Hui Zhao, Lin Chen, Tian Yang, Ya-Long Feng, Nosratola D. Vaziri, Bao-Li Liu, Qing-Quan Liu, Yan Guo, Ying-Yong Zhao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy

Teofila Seremet, Yanina Jansen, Simon Planken, Hassan Njimi, Mélanie Delaunoy, Hakim El Housni, Gil Awada, Julia Katharina Schwarze, Marleen Keyaerts, Hendrik Everaert, Danielle Lienard, Véronique Del Marmol, Pierre Heimann, Bart Neyns

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Aryl hydrocarbon receptor ligands enhance lung immunity through intestinal IKKβ pathways

Tzyy-Bin Tsay, Pei-Hsuan Chen, Lee-Wei Chen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Modeling trauma in rats: similarities to humans and potential pitfalls to consider

Birte Weber, Ina Lackner, Melanie Haffner-Luntzer, Annette Palmer, Jochen Pressmar, Karin Scharffetter-Kochanek, Bernd Knöll, Hubert Schrezenemeier, Borna Relja, Miriam Kalbitz

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Transitioning from acute to chronic pain: a simulation study of trajectories of low back pain

Jianzhong Su, Ying Du, Kelley Bevers, Pengcheng Xiao, John Licciardone, Marco Brotto, Robert J. Gatchel

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Biofluid quantification of TWEAK/Fn14 axis in combination with a selected biomarker panel improves assessment of prostate cancer aggressiveness

Xavier Ruiz-Plazas, Esther Rodríguez-Gallego, Marta Alves, Antonio Altuna-Coy, Javier Lozano-Bartolomé, Manel Portero-Otin, Joan Francesc García-Fontgivell, Salomé Martínez-González, José Segarra, Matilde R. Chacón

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Estrogen receptors promote NSCLC progression by modulating the membrane receptor signaling network: a systems biology perspective

Xiujuan Gao, Yue Cai, Zhuo Wang, Wenjuan He, Sisi Cao, Rong Xu, Hui Chen

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The role of collagen in cancer: from bench to bedside

Shuaishuai Xu, Huaxiang Xu, Wenquan Wang, Shuo Li, Hao Li, Tianjiao Li, Wuhu Zhang, Xianjun Yu, Liang Liu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern

Kacper Toczylowski, Tomasz Hirnle, Dorota Harasiuk, Piotr Zabielski, Anna Lewczuk, Iwona Dmitruk, Monika Ksiazek, Artur Sulik, Jan Gorski, Adrian Chabowski, Marcin Baranowski

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data

Ning Xu, Yu-Peng Wu, Zhi-Bin Ke, Ying-Chun Liang, Hai Cai, Wen-Ting Su, Xuan Tao, Shao-Hao Chen, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Photopheresis efficacy in the treatment of rheumatoid arthritis: a pre-clinical proof of concept

Céline Coppard, Francis Bonnefoy, Dalil Hannani, Françoise Gabert, Olivier Manches, Joel Plumas, Sylvain Perruche, Laurence Chaperot

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Red meat and dietary iron intakes are associated with some components of metabolic syndrome: Tehran Lipid and Glucose Study

Zohre Esfandiar, Firoozeh Hosseini-Esfahani, Parvin Mirmiran, Ali-Siamak Habibi-Moeini, Fereidoun Azizi

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

Discrimination of indoor versus outdoor environmental state with machine learning algorithms in myopia observational studies

Bin Ye, Kangping Liu, Siting Cao, Padmaja Sankaridurg, Wayne Li, Mengli Luan, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu, Xiangui He

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: New paradigm for stage III melanoma: from surgery to adjuvant treatment

Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli, Corrado Caracò

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Direct S-Poly(T) Plus assay in quantification of microRNAs without RNA extraction and its implications in colorectal cancer biomarker studies

Yanqin Niu, Sijian Xia, Mingyang Su, Quanjin Dang, Kang Kang, Li Li, Deming Gou

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Personalized prediction of live birth prior to the first in vitro fertilization treatment: a machine learning method

Jiahui Qiu, Pingping Li, Meng Dong, Xing Xin, Jichun Tan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The role of radiotherapy in metaplastic breast cancer: a propensity score-matched analysis of the SEER database

Yongfeng Li, Meng Chen, Barbara Pardini, Mihnea P. Dragomir, Anthony Lucci, George A. Calin

01.12.2019 | Review | Ausgabe 1/2019 Open Access

RNA editing in the forefront of epitranscriptomics and human health

Theodoulakis Christofi, Apostolos Zaravinos

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comprehensive analysis of aberrantly expressed profiles of mRNA and its relationship with serum galactose-deficient IgA1 level in IgA nephropathy

Youxia Liu, Xiangchun Liu, Junya Jia, Jie Zheng, Tiekun Yan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization

Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian, Conrad Russell Y. Cruz

01.12.2019 | Research | Ausgabe 1/2019 Open Access

WBNPMD: weighted bipartite network projection for microRNA-disease association prediction

Guobo Xie, Zhiliang Fan, Yuping Sun, Cuiming Wu, Lei Ma

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

Xi-Xi Li, Yang Liu, Jie Luo, Zhen-Dong Huang, Chao Zhang, Yan Fu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Methylation and transcriptome analysis reveal lung adenocarcinoma-specific diagnostic biomarkers

Rui Li, Yi-E Yang, Yun-Hong Yin, Meng-Yu Zhang, Hao Li, Yi-Qing Qu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon tumor cells in a miRNA-dependent manner

Shimon Reif, Yaffa Elbaum Shiff, Regina Golan-Gerstl

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Predictive model for acute respiratory distress syndrome events in ICU patients in China using machine learning algorithms: a secondary analysis of a cohort study

Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu, Tong-Wen Sun

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CircRNA expression profiles in human dental pulp stromal cells undergoing oxidative stress

Jingying Zhang, Dan Li, Dan Wang, Kenny Man, Xuebin Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial

Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner, Jens Ricke

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury

Hung-Chen Wang, Yu-Tsai Lin, Shih-Yuan Hsu, Nai-Wen Tsai, Yun-Ru Lai, Ben Yu-Jih Su, Chia-Te Kung, Cheng-Hsien Lu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology

Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio, Emilia Maggio, Matteo Bertelli

01.12.2019 | Research | Ausgabe 1/2019 Open Access

90-gene signature assay for tissue origin diagnosis of brain metastases

Yulong Zheng, Yongfeng Ding, Qifeng Wang, Yifeng Sun, Xiaodong Teng, Qiqi Gao, Weixiang Zhong, Xiaofeng Lou, Cheng Xiao, Chengshu Chen, Qinghua Xu, Nong Xu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder

P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi, P. Visconti

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tissue diagnosis during colorectal cancer surgery using optical sensing: an in vivo study

E. J. M. Baltussen, S. G. Brouwer de Koning, J. Sanders, A. G. J. Aalbers, N. F. M. Kok, G. L. Beets, B. H. W. Hendriks, H. J. C. M. Sterenborg, K. F. D. Kuhlmann, T. J. M. Ruers

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study

Line Moi, Tonje Braaten, Khalid Al-Shibli, Eiliv Lund, Lill-Tove Rasmussen Busund

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3/P38 MAPK signaling pathway

Feng He, Zonghui Xiao, Hailan Yao, Sen Li, Miao Feng, Wei Wang, Zhewei Liu, Zhuo Liu, Jianxin Wu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CCNB1 affects cavernous sinus invasion in pituitary adenomas through the epithelial–mesenchymal transition

Bin Li, Jianhua Cheng, Hongyun Wang, Sida Zhao, Haibo Zhu, Chuzhong Li, Yazhuo Zhang, Peng Zhao

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Bringing radiomics into a multi-omics framework for a comprehensive genotype–phenotype characterization of oncological diseases

Mario Zanfardino, Monica Franzese, Katia Pane, Carlo Cavaliere, Serena Monti, Giuseppina Esposito, Marco Salvatore, Marco Aiello

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm

Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem, Zvia Agur

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tracking longitudinal genetic changes of circulating tumor DNA (ctDNA) in advanced Lung adenocarcinoma treated with chemotherapy

Xiaohong Han, Ying Han, Qiaoyun Tan, Yu Huang, Jianliang Yang, Sheng Yang, Xiaohui He, Shengyu Zhou, Yan Song, Jinping Pi, Lijie Zuo, Jiarui Yao, Di Wu, Zhishang Zhang, Yuankai Shi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Computer algorithm can match physicians’ decisions about blood transfusions

Yuanyuan Yao, Jenny Cifuentes, Bin Zheng, Min Yan

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Visceral adipose accumulation increased the risk of hyperuricemia among middle-aged and elderly adults: a population-based study

Xiaolin Huang, Xiaohong Jiang, Long Wang, Lu Chen, Yang Wu, Pei Gao, Fei Hua

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development

Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen, Emanuela Taioli

01.12.2019 | Research | Ausgabe 1/2019 Open Access

PYCR1 interference inhibits cell growth and survival via c-Jun N-terminal kinase/insulin receptor substrate 1 (JNK/IRS1) pathway in hepatocellular cancer

Juhua Zhuang, Yanan Song, Ying Ye, Saifei He, Xing Ma, Miao Zhang, Jing Ni, Jiening Wang, Wei Xia

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic significance of peripheral CD8+CD28+ and CD8+CD28− T cells in advanced non-small cell lung cancer patients treated with chemo(radio)therapy

Chao Liu, Wang Jing, Ning An, Aijie Li, Weiwei Yan, Hui Zhu, Jinming Yu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

DNA methylation exploration for ARDS: a multi-omics and multi-microarray interrelated analysis

Shi Zhang, Zongsheng Wu, Jianfeng Xie, Yi Yang, Lei Wang, Haibo Qiu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Vincent Minville, Lionel Mouledous, Acil Jaafar, Réjean Couture, Anne Brouchet, Bernard Frances, Ivan Tack, Jean-Pierre Girolami

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic values of microRNA-130 family expression in patients with cancer: a meta-analysis and database test

Zhen Peng, Fujiao Duan, Jingjing Yin, Yajing Feng, Zhongyu Yang, Jia Shang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

Haya Al-Sulaiti, Ilhame Diboun, Maha V. Agha, Fatima F. S. Mohamed, Stephen Atkin, Alex S. Dömling, Mohamed A. Elrayess, Nayef A. Mazloum

01.12.2019 | Protocol | Ausgabe 1/2019 Open Access

The natural course of unruptured intracranial aneurysms in a Chinese cohort: protocol of a multi-center registration study in CIAP

Haixiao Liu, Wei Guo, Sishi Xiang, Peng Hu, Feifei Sun, Junmei Gao, Xiaoyang Zhang, Ping Wang, Wenting Jing, Lei Zhang, Xinjian Yang, Chuanzhi Duan, Min He, Hongqi Zhang, Yan Qu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mild hyperthermia by MR-guided focused ultrasound in an ex vivo model of osteolytic bone tumour: optimization of the spatio-temporal control of the delivered temperature

Pauline C. Guillemin, Laura Gui, Orane Lorton, Thomas Zilli, Lindsey A. Crowe, Stéphane Desgranges, Xavier Montet, Sylvain Terraz, Raymond Miralbell, Rares Salomir, Sana Boudabbous

01.12.2019 | Research | Ausgabe 1/2019 Open Access

First confirmatory study on PTPRQ as an autosomal dominant non-syndromic hearing loss gene

Dominika Oziębło, Anna Sarosiak, Marcin L. Leja, Birgit S. Budde, Grażyna Tacikowska, Nataliya Di Donato, Hanno J. Bolz, Peter Nürnberg, Henryk Skarżyński, Monika Ołdak

01.12.2019 | Research | Ausgabe 1/2019 Open Access

CD36 promotes the epithelial–mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β

Min Deng, Xiaodong Cai, Ling Long, Linying Xie, Hongmei Ma, Youjian Zhou, Shuguang Liu, Chao Zeng

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Analysis of prognosis, genome, microbiome, and microbial metabolome in different sites of colorectal cancer

Yang Xi, Pan Yuefen, Wu Wei, Qi Quan, Zhuang Jing, Xu Jiamin, Han Shuwen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma

Haibo Zhu, Yazhou Miao, Yutao Shen, Jing Guo, Weiyan Xie, Sida Zhao, Wei Dong, Yazhuo Zhang, Chuzhong Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients

Chuling Li, Chuwei Li, Chunchun Zhi, Wenjun Liang, Xuan Wang, Xi Chen, Tangfeng Lv, Qin Shen, Yong Song, Dang Lin, Hongbing Liu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide

Giovanna Muscogiuri, Luigi Barrea, Daniela Laudisio, Gabriella Pugliese, Ciro Salzano, Silvia Savastano, Annamaria Colao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort

Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si, Rebecca Halpin, Todd Creasy, Ronald Herbst, Xing Ren, Pascale Morel, Alessandra Cesano, François Goldwasser, Karen Leroy

01.12.2019 | Correction | Ausgabe 1/2019 Open Access

Correction to: Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy

Longwen Xu, Zhiyuan Cheng, Chuanliang Cui, Xiaowen Wu, Huan Yu, Jun Guo, Yan Kong

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A prospective study of acute kidney injury in the intensive care unit: development and validation of a risk prediction model

Qi Wang, Yi Tang, Jiaojiao Zhou, Wei Qin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results

Abbas Ali Qayyum, Anders Bruun Mathiasen, Steffen Helqvist, Erik Jørgensen, Mandana Haack-Sørensen, Annette Ekblond, Jens Kastrup

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Placental mitochondrial DNA content is associated with childhood intelligence

Esmée M. Bijnens, Catherine Derom, Steven Weyers, Bram G. Janssen, Evert Thiery, Tim S. Nawrot

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study

Muhammad Tahir ul Qamar, Saman Saleem, Usman Ali Ashfaq, Amna Bari, Farooq Anwar, Safar Alqahtani

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic implications of Aquaporin 9 expression in clear cell renal cell carcinoma

Wen-Hao Xu, Shen-Nan Shi, Yue Xu, Jun Wang, Hong-Kai Wang, Da-Long Cao, Guo-Hai Shi, Yuan-Yuan Qu, Hai-Liang Zhang, Ding-Wei Ye

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy

Salvatore Venosi, Giancarlo Ceccarelli, Massimiliano de Angelis, Luca Laghi, Laura Bianchi, Ombretta Martinelli, Debora Maruca, Eugenio Nelson Cavallari, Fabrizia Toscanella, Paolo Vassalini, Vito Trinchieri, Alessandra Oliva, Gabriella d’Ettorre

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia

Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler

01.12.2019 | Research | Ausgabe 1/2019 Open Access

HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia

Zhengchang He, Siyu Zhang, Dan Ma, Qin Fang, Liping Yang, Shaoxian Shen, Ying Chen, Lingli Ren, Jishi Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating PCSK9 and cardiovascular events in FH patients with standard lipid-lowering therapy

Ye-Xuan Cao, Jing-Lu Jin, Di Sun, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Cheng-Gang Zhu, Qian Dong, Jing Sun, Jian-Jun Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Systemic microvascular rarefaction is correlated with dysfunction of late endothelial progenitor cells in mild hypertension: a substudy of EXCAVATION-CHN1

Jianwen Liang, Yan Li, Long Chen, Wenhao Xia, Guifu Wu, Xinzhu Tong, Chen Su, Jiang He, Xiufang Lin, Jun Tao

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Oxidized low density lipoprotein receptor 1 promotes lung metastases of osteosarcomas through regulating the epithelial-mesenchymal transition

Long Jiang, Shanshan Jiang, Wenjie Zhou, Jia Huang, Yongbin Lin, Hao Long, Qingquan Luo

01.12.2019 | Review | Ausgabe 1/2019 Open Access

In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network

Margalida Esteva-Socias, María-Jesús Artiga, Olga Bahamonde, Oihana Belar, Raquel Bermudo, Erika Castro, Teresa Escámez, Máximo Fraga, Laura Jauregui-Mosquera, Isabel Novoa, Lorena Peiró-Chova, Juan-David Rejón, María Ruiz-Miró, Paula Vieiro-Balo, Virginia Villar-Campo, Sandra Zazo, Alberto Rábano, Cristina Villena

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

Purification of viable peripheral blood mononuclear cells for biobanking using a robotized liquid handling workstation

Luigi Coppola, Giovanni Smaldone, Alessandra Cianflone, Simona Baselice, Peppino Mirabelli, Marco Salvatore

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia

Andrea Rzepiel, Nóra Kutszegi, András Gézsi, Judit C. Sági, Bálint Egyed, György Péter, Henriett Butz, Gábor Nyírő, Judit Müller, Gábor T. Kovács, Csaba Szalai, Ágnes F. Semsei, Dániel J. Erdélyi

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Exploring the whole standard operating procedure for phage therapy in clinical practice

Zelin Cui, Xiaokui Guo, Tingting Feng, Li Li

01.12.2019 | Methodology | Ausgabe 1/2019 Open Access

The OncoLifeS data-biobank for oncology: a comprehensive repository of clinical data, biological samples, and the patient’s perspective

Grigory Sidorenkov, Janny Nagel, Coby Meijer, Jacko J. Duker, Harry J. M. Groen, Gyorgy B. Halmos, Maaike H. M. Oonk, Rene J. Oostergo, Bert van der Vegt, Max J. H. Witjes, Marcel Nijland, Klaas Havenga, John H. Maduro, Jourik A. Gietema, Gertruida H. de Bock

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis

Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Early fatigue in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: an insight from clinical practice

Alessio Cortellini, Maria G. Vitale, Federica De Galitiis, Francesca R. Di Pietro, Rossana Berardi, Mariangela Torniai, Michele De Tursi, Antonino Grassadonia, Pietro Di Marino, Daniele Santini, Tea Zeppola, Cecilia Anesi, Alain Gelibter, Mario Alberto Occhipinti, Andrea Botticelli, Paolo Marchetti, Francesca Rastelli, Federica Pergolesi, Marianna Tudini, Rosa Rita Silva, Domenico Mallardo, Vito Vanella, Corrado Ficorella, Giampiero Porzio, Paolo A. Ascierto

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Comparison and characterization of enriched mesenchymal stem cells obtained by the repeated filtration of autologous bone marrow through porous biomaterials

Wenxiang Chu, Yifu Zhuang, Yaokai Gan, Xin Wang, Tingting Tang, Kerong Dai

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow

Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou, Bo Yu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer

Yue-Xin Hu, Ming-Jun Zheng, Wen-Chao Zhang, Xiao Li, Rui Gou, Xin Nie, Qing Liu, Ying-Ying Hao, Juan-Juan Liu, Bei Lin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A novel epigenetic signature for overall survival prediction in patients with breast cancer

Xuanwen Bao, Natasa Anastasov, Yanfang Wang, Michael Rosemann

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identifying genetic variants underlying medication-induced osteonecrosis of the jaw in cancer and osteoporosis: a case control study

Kye Hwa Lee, Su-Hwan Kim, Chang Hyen Kim, Byung Joo Min, Grace Juyun Kim, Younggyun Lim, Hun-Sung Kim, Kang-Min Ahn, Ju Han Kim

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Predicting drug−disease associations via sigmoid kernel-based convolutional neural networks

Han-Jing Jiang, Zhu-Hong You, Yu-An Huang

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Current progress in hepatic tissue regeneration by tissue engineering

Vahid Hosseini, Nazila Fathi Maroufi, Sepideh Saghati, Nahideh Asadi, Masoud Darabi, Saeed Nazari Soltan Ahmad, Hosseini Hosseinkhani, Reza Rahbarghazi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A prospective evaluation of thiamine and magnesium status in relation to clinicopathological characteristics and 1-year mortality in patients with alcohol withdrawal syndrome

Donogh Maguire, Dinesh Talwar, Alana Burns, Anthony Catchpole, Fiona Stefanowicz, Gordon Robson, David P. Ross, David Young, Alastair Ireland, Ewan Forrest, Peter Galloway, Michael Adamson, Eoghan Colgan, Hannah Bell, Lesley Orr, Joanna-Lee Kerr, Xen Roussis, Donald C. McMillan

01.12.2019 | Protocol | Ausgabe 1/2019 Open Access

Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy

Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant, Yangming Ou

01.12.2019 | Research | Ausgabe 1/2019 Open Access

BMI, irAE, and gene expression signatures associate with resistance to immune-checkpoint inhibition and outcomes in renal cell carcinoma

Brian W. Labadie, Ping Liu, Riyue Bao, Michael Crist, Ricardo Fernandes, Laura Ferreira, Scott Graupner, Andrew S. Poklepovic, Ignacio Duran, Saman Maleki Vareki, Arjun V. Balar, Jason J. Luke

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The pathogenesis of renal injury and treatment in light chain deposition disease

Qi Wang, Fang Jiang, Gaosi Xu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Renal involvement and metabolic alterations in adults patients affected by cystic fibrosis

Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Nonlinear relationship between serum uric acid and body mass index: a cross-sectional study of a general population in coastal China

Hui Zhou, Zhen Liu, Zhong Chao, Yeqing Chao, Lidan Ma, Xiaoyu Cheng, Yangang Wang, Changgui Li, Ying Chen

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Loss of alanine-glyoxylate and serine-pyruvate aminotransferase expression accelerated the progression of hepatocellular carcinoma and predicted poor prognosis

Yufeng Sun, Wenchao Li, Shiqi Shen, Xuejing Yang, Bing Lu, Xiaojing Zhang, Peng Lu, Yi Shen, Juling Ji

01.12.2019 | Protocol | Ausgabe 1/2019 Open Access

A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma

Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg, Lana E. Kandalaft

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Downregulation of exosomal miR-192-5p and miR-204-5p in subjects with nonclassic apparent mineralocorticoid excess

Alejandra Tapia-Castillo, Dominic Guanzon, Carlos Palma, Andrew Lai, Eric Barros, Fidel Allende, Andrea Vecchiola, Carlos E. Fardella, Carlos Salomón, Cristian A. Carvajal

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China

Xu Zhang, Guiji Li, Zhuren Zhou, Chaopeng Shao, Xuying Huang, Lichun Li, Xiaofeng Li, Ying Liu, Hua Fan, Jianping Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The dynamics of the inflammatory response during BBN-induced bladder carcinogenesis in mice

Marina Degoricija, Jelena Korac-Prlic, Katarina Vilovic, Tonci Ivanisevic, Benedikt Haupt, Vinko Palada, Marina Petkovic, Ivana Karaman, Janos Terzic

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A few ethical issues in translational research for gene and cell therapy

Luciana Riva, Carlo Petrini

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Ovarian function and reproductive outcome after ovarian tissue transplantation: a systematic review

Sepideh Sheshpari, Mahnaz Shahnazi, Halimeh Mobarak, Shahin Ahmadian, Alberto Miranda Bedate, Ziba Nariman-Saleh-Fam, Mohammad Nouri, Reza Rahbarghazi, Mahdi Mahdipour

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review

Soukaina Bahsoun, Karen Coopman, Elizabeth C. Akam

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Usefulness and reliability of cell free fetal DNA screening for main trisomies in case of atypical profile on first trimester maternal serum screening

Julie Carrara, Alexandre Vivanti, Jacques C. Jani, Adèle Demain, Jean-Marc Costa, Alexandra Benachi

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Mitochondrial DNA methylation and copy number predict body composition in a young female population

Laura Bordoni, Vanessa Smerilli, Cinzia Nasuti, Rosita Gabbianelli

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Beneficial effects of xenon inhalation on behavioral changes in a valproic acid-induced model of autism in rats

A. P. Dobrovolsky, V. R. Gedzun, V. I. Bogin, D. Ma, T. E. Ichim, Iu. A. Sukhanova, A. V. Malyshev, V. A. Dubynin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Transient receptor potential melastatin 2 channels are overexpressed in myalgic encephalomyelitis/chronic fatigue syndrome patients

Cassandra Balinas, Helene Cabanas, Donald Staines, Sonya Marshall-Gradisnik

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The prognostic role of circulating CD8+ T cell proliferation in patients with untreated extensive stage small cell lung cancer

Ning An, Haoyi Wang, Wenxiao Jia, Wang Jing, Chao Liu, Hui Zhu, Jinming Yu

01.12.2019 | Commentary | Ausgabe 1/2019 Open Access

Does HOTAIR expression level in the peripheral blood have veritably predictive/prognostic impact on breast cancer patients?

Vahid Ezzatizadeh, Hossein Mozdarani

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Two precision medicine predictive tools for six malignant solid tumors: from gene-based research to clinical application

Zhiqiao Zhang, Tingshan He, Liwen Huang, Yanling Ouyang, Jing Li, Yiyan Huang, Peng Wang, Jianqiang Ding

01.12.2019 | Research | Ausgabe 1/2019 Open Access

IgA1 deposition may induce NLRP3 expression and macrophage transdifferentiation of podocyte in IgA nephropathy

Wei Peng, Gai-qin Pei, Yi Tang, Li Tan, Wei Qin

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles

Sen Cheng, Weiyan Xie, Yazhou Miao, Jing Guo, Jichao Wang, Chuzhong Li, Yazhuo Zhang

01.12.2019 | Protocol | Ausgabe 1/2019 Open Access

Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study

Benedetta M. Motta, Christoph Grander, Martin Gögele, Luisa Foco, Vladimir Vukovic, Roberto Melotti, Christian Fuchsberger, Alessandro De Grandi, Chiara Cantaloni, Anne Picard, Deborah Mascalzoni, Alessandra Rossini, Cristian Pattaro, Herbert Tilg, Peter P. Pramstaller

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Circulating levels of GDF15 in patients with myalgic encephalomyelitis/chronic fatigue syndrome

A. Melvin, E. Lacerda, H. M. Dockrell, S. O’Rahilly, L. Nacul

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Triglyceride is an independent predictor of type 2 diabetes among middle-aged and older adults: a prospective study with 8-year follow-ups in two cohorts

Jing Zhao, Yuan Zhang, Fengjiang Wei, Jiani Song, Zhi Cao, Chen Chen, Kai Zhang, Shuzhi Feng, Yaogang Wang, Wei-Dong Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials

Long Wang, Hong Yang, Hao Huang, Chao Zhang, Hong-Xia Zuo, Pan Xu, Yu-Ming Niu, Shi-Shi Wu

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Prognostic nomogram for bladder cancer with brain metastases: a National Cancer Database analysis

Zhixian Yao, Zhong Zheng, Wu Ke, Renjie Wang, Xingyu Mu, Feng Sun, Xiang Wang, Shivank Garg, Wenyin Shi, Yinyan He, Zhihong Liu

01.12.2019 | Review | Ausgabe 1/2019 Open Access

The immunoregulation of mesenchymal stem cells plays a critical role in improving the prognosis of liver transplantation

Chenxia Hu, Lanjuan Li

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Fibrosis independent atrial fibrillation in older patients is driven by substrate leukocyte infiltration: diagnostic and prognostic implications to patients undergoing cardiac surgery

Christie M. Aguiar, Kareem Gawdat, Stephanie Legere, Jean Marshall, Ansar Hassan, Petra C. Kienesberger, Thomas Pulinilkunnil, Mathieu Castonguay, Keith R. Brunt, Jean-Francois Legare

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Elevated MR-proANP plasma concentrations are associated with sepsis and predict mortality in critically ill patients

Eray Yagmur, Johanna Hermine Sckaer, Ger H. Koek, Ralf Weiskirchen, Christian Trautwein, Alexander Koch, Frank Tacke

01.12.2019 | Research | Ausgabe 1/2019 Open Access

FXR activation alleviates tacrolimus-induced post-transplant diabetes mellitus by regulating renal gluconeogenesis and glucose uptake

Ling Li, Huijia Zhao, Binyao Chen, Zhipeng Fan, Ning Li, Jiang Yue, Qifa Ye

01.12.2019 | Review | Ausgabe 1/2019 Open Access

Integrating omics for a better understanding of Inflammatory Bowel Disease: a step towards personalized medicine

Manoj Kumar, Mathieu Garand, Souhaila Al Khodor

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Correlation of PMN elastase and PMN elastase-to-neutrophil ratio with disease activity in patients with myositis

Siyu Wu, Wanchan Peng, Yunli Zhang, Jingjing Guo, Jinfang Fu, Wei Wang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Lupus serum IgG induces microglia activation through Fc fragment dependent way and modulated by B-cell activating factor

Chunshu Yang, Xiaoyu Hou, Qianhui Feng, Yingzhuo Li, Xuejiao Wang, Ling Qin, Pingting Yang

01.12.2019 | Research | Ausgabe 1/2019 Open Access

A novel method for efficient generation of antigen-specific effector T-cells using dendritic cells transduced with recombinant adeno-associated virus and p38 kinase blockade

Leonardo Mirandola, Maurizio Chiriva-Internati, Robert Bresalier, Lucia Piccotti, Fabio Grizzi, Francesco M. Marincola

01.12.2019 | Research | Ausgabe 1/2019 Open Access

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck

Sara I. Pai, Ezra E. W. Cohen, Derrick Lin, George Fountzilas, Edward S. Kim, Holger Mehlhorn, Neus Baste, Daniel Clayburgh, Loren Lipworth, Carlo Resteghini, Nawar Shara, Takashi Fujii, Jun Zhang, Michael Stokes, Huifen Wang, Philip Twumasi-Ankrah, Sophie Wildsmith, Asud Khaliq, Giovanni Melillo, Norah Shire

01.12.2019 | Research | Ausgabe 1/2019 Open Access

Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity

Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao, Jie He

01.12.2019 | Research | Ausgabe 1/2019 Open Access

The important role of connexin 43 in subarachnoid hemorrhage-induced cerebral vasospasm

Le Yang, Jian Yan, Jin-An Zhang, Xin-Hui Zhou, Chao Fang, Er-Ming Zeng, Bin Tang, Jian Duan, Guo-Hui Lu, Tao Hong

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