01.12.2019 | Research | Ausgabe 1/2019
Open Access
Identification of a serum-based miRNA signature for response of esophageal squamous cell carcinoma to neoadjuvant chemotherapy
Yukiko Niwa, Suguru Yamada, Fuminori Sonohara, Keisuke Kurimoto, Masamichi Hayashi, Mitsuru Tashiro, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Goro Nakayama, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
01.12.2019 | Research | Ausgabe 1/2019
Open Access
In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells
Valentina Masola, Amedeo Carraro, Simona Granata, Lorenzo Signorini, Gloria Bellin, Paola Violi, Antonio Lupo, Umberto Tedeschi, Maurizio Onisto, Giovanni Gambaro, Gianluigi Zaza
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Translational control mechanisms in cutaneous malignant melanoma: the role of eIF2α
Immacolata Maida, Paola Zanna, Stefania Guida, Anna Ferretta, Tiziana Cocco, Luigi Leonardo Palese, Paola Londei, Dario Benelli, Amalia Azzariti, Stefania Tommasi, Michele Guida, Giovanni Pellacani, Gabriella Guida
01.12.2019 | Research | Ausgabe 1/2019
Open Access
MicroRNA-regulated pathways of flow-stimulated angiogenesis and vascular remodeling in vivo
Dominic Henn, Masood Abu-Halima, Dominik Wermke, Florian Falkner, Benjamin Thomas, Christoph Köpple, Nicole Ludwig, Matthias Schulte, Marc A. Brockmann, Yoo-Jin Kim, Justin M. Sacks, Ulrich Kneser, Andreas Keller, Eckart Meese, Volker J. Schmidt
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Single cell sequencing reveals gene expression signatures associated with bone marrow stromal cell subpopulations and time in culture
Shutong Liu, David F. Stroncek, Yingdong Zhao, Victoria Chen, Rongye Shi, Jinguo Chen, Jiaqiang Ren, Hui Liu, Hee Joon Bae, Steven L. Highfill, Ping Jin
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Three-dimensional nanostructured substrates enable dynamic detection of ALK-rearrangement in circulating tumor cells from treatment-naive patients with stage III/IV lung adenocarcinoma
Weiling He, Di Xu, Zhuo Wang, Hui Wu, Xianhong Xiang, Bing Tang, Wenting Jiang, Yongmei Cui, Han Wang, Neng Jiang, Yu Sun, Yangshan Chen, Shuhua Li, Minzhi Hou, Yang Zhang, Liantang Wang, Zun-fu Ke
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Climate, human behaviour or environment: individual-based modelling of Campylobacter seasonality and strategies to reduce disease burden
Stephen P. Rushton, Roy A. Sanderson, Peter J. Diggle, Mark D. F. Shirley, Alasdair P. Blain, Iain Lake, James A. Maas, William D. K. Reid, Jo Hardstaff, Nicola Williams, Natalia R. Jones, Daniel Rigby, Norval J. C. Strachan, Ken J. Forbes, Paul R. Hunter, Thomas J. Humphrey, Sarah J. O’Brien
01.12.2019 | Research | Ausgabe 1/2019
Open Access
LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production
Meiyu Zhang, Chengcheng Yao, Jun Cai, Shuai Liu, Xia-nan Liu, Yingying Chen, Shujun Wang, Ping Ji, Meng Pan, Zizhen Kang, Ying Wang
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Mathematical models of amino acid panel for assisting diagnosis of children acute leukemia
Zhidai Liu, Tingting Zhou, Xing Han, Tingyuan Lang, Shan Liu, Penghui Zhang, Haiyan Liu, Kexing Wan, Jie Yu, Liang Zhang, Liyan Chen, Roger W. Beuerman, Bin Peng, Lei Zhou, Lin Zou
01.12.2019 | Research | Ausgabe 1/2019
Open Access
New risk score for predicting progression of membranous nephropathy
Hu Xiaofan, Xu Jing, Gao Chenni, Wu Yifan, Yu Xialian, Lin Li, Ren Hong, Zhang Wen, Wang Weiming, Pan Xiaoxia, Xie Jingyuan, Chen Nan
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Discriminatory ability of anthropometric measurements of central fat distribution for prediction of post-prandial hyperglycaemia in patients with normal fasting glucose: the DICAMANO Study
Belén Pérez-Pevida, Jorge M. Núñez-Córdoba, Sonia Romero, Alexander Dimitri Miras, Patricia Ibañez, Neus Vila, María Ángeles Margall, Camilo Silva, Javier Salvador, Gema Frühbeck, Javier Escalada
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study
Azize Boström, Dirk Scheele, Birgit Stoffel-Wagner, Frigga Hönig, Shafqat R. Chaudhry, Sajjad Muhammad, Rene Hurlemann, Joachim K. Krauss, Ilana S. Lendvai, Krishnan V. Chakravarthy, Thomas M. Kinfe
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Jaw osteosarcoma models in mice: first description
Hélios Bertin, Romain Guilho, Régis Brion, Jérôme Amiaud, Séverine Battaglia, Anne Moreau, Anne Brouchet-Gomez, Julie Longis, Benoit Piot, Dominique Heymann, Pierre Corre, Françoise Rédini
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Bioinformatics-based discovery of the urinary BBOX1 mRNA as a potential biomarker of diabetic kidney disease
Le-Ting Zhou, Lin-Li Lv, Shen Qiu, Qing Yin, Zuo-Lin Li, Tao-Tao Tang, Li-Hua Ni, Ye Feng, Bin Wang, Kun-Ling Ma, Bi-Cheng Liu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia
R. Ellis, M. Katerelos, S. W. Choy, N. Cook, M. Lee, K. Paizis, G. Pell, S. Walker, D. A. Power, P. F. Mount
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Computer-aided assessment of the extra-cellular matrix during pancreatic carcinogenesis: a pilot study
Fabio Grizzi, Sirio Fiorino, Dorina Qehajaj, Adele Fornelli, Carlo Russo, Dario de Biase, Michele Masetti, Laura Mastrangelo, Matteo Zanello, Raffaele Lombardi, Andrea Domanico, Esterita Accogli, Andrea Tura, Leonardo Mirandola, Maurizio Chiriva-Internati, Robert S. Bresalier, Elio Jovine, Paolo Leandri, Luca Di Tommaso
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway
Yonghan Peng, Ziyu Fang, Min Liu, Zeyu Wang, Ling Li, Shaoxiong Ming, Chaoyue Lu, Hao Dong, Wenhui Zhang, Qi Wang, Rong Shen, Fei Xie, Weitao Zhang, Cheng Yang, Xiaofeng Gao, Yinghao Sun
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A robust qualitative transcriptional signature for the correct pathological diagnosis of gastric cancer
Haidan Yan, Meifeng Li, Longlong Cao, Haifeng Chen, Hungming Lai, Qingzhou Guan, Huxing Chen, Wenbin Zhou, Baotong Zheng, Zheng Guo, Chaohui Zheng
01.12.2019 | Research | Ausgabe 1/2019
Open Access
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway
Ya-nan Bie, Peng Gu, Yu-ting Chen, Xiao-xu Zhou, Yu-guang Tian, Qin Yang, Hai-yan Li, Xia Lin, Yan-hong Guan, Tao-yan Lin, Xun Lu, Hong-fen Shen, Ting-xiao Fang, Yu-min Liu, Dong Xiao, Wei-Wang Gu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Chromosome screening using culture medium of embryos fertilised in vitro: a pilot clinical study
Rui Fang, Weimin Yang, Xin Zhao, Fang Xiong, Caiqing Guo, Jianping Xiao, Li Chen, Xiaoqing Song, Honghua Wang, Jie Chen, Xiao Xiao, Bing Yao, Li-Yi Cai
01.12.2019 | Research | Ausgabe 1/2019
Open Access
The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients
M. G. Dal Bello, R. A. Filiberti, A. Alama, A. M. Orengo, M. Mussap, S. Coco, I. Vanni, S. Boccardo, E. Rijavec, C. Genova, F. Biello, G. Barletta, G. Rossi, M. Tagliamento, C. Maggioni, F. Grossi
01.12.2019 | Methodology | Ausgabe 1/2019
Open Access
Polyethylene glycol improves current methods for circulating extracellular vesicle-derived DNA isolation
N. García-Romero, R. Madurga, G. Rackov, I. Palacín-Aliana, R. Núñez-Torres, A. Asensi-Puig, J. Carrión-Navarro, S. Esteban-Rubio, H. Peinado, A. González-Neira, V. González-Rumayor, C. Belda-Iniesta, A. Ayuso-Sacido
01.12.2019 | Research | Ausgabe 1/2019
Open Access
m6A RNA modification and its writer/reader VIRMA/YTHDF3 in testicular germ cell tumors: a role in seminoma phenotype maintenance
João Lobo, Ana Laura Costa, Mariana Cantante, Rita Guimarães, Paula Lopes, Luís Antunes, Isaac Braga, Jorge Oliveira, Mattia Pelizzola, Rui Henrique, Carmen Jerónimo
01.12.2019 | Methodology | Ausgabe 1/2019
Open Access
Production of a cellular product consisting of monocytes stimulated with Sylatron® (Peginterferon alfa-2b) and Actimmune® (Interferon gamma-1b) for human use
Daniel S. Green, Ana T. Nunes, Kevin W. Tosh, Virginia David-Ocampo, Vicki S. Fellowes, Jiaqiang Ren, Jianjian Jin, Sue-Ellen Frodigh, Chauha Pham, Jolynn Procter, Celina Tran, Irene Ekwede, Hanh Khuu, David F. Stroncek, Steven L. Highfill, Kathryn C. Zoon, Christina M. Annunziata
01.12.2019 | Correction | Ausgabe 1/2019
Open Access
Correction to: Recurrent pregnancy loss is associated to leaky gut: a novel pathogenic model of endometrium inflammation?
C. Tersigni, S. D’Ippolito, F. Di Nicuolo, R. Marana, V. Valenza, V. Masciullo, F. Scaldaferri, F. Malatacca, C. de Waure, A. Gasbarrini, G. Scambia, N. Di Simone
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)
Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He, Hui Xu, C-STRIDE study group
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis
Zibo Li, Yukun Lin, Shuhui Zhang, Lin Zhou, Guixi Yan, Yuehua Wang, Mengdi Zhang, Mengqi Wang, Haihong Lin, Qiaozhen Tong, Yongjian Duan, Gangjun Du
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Longitudinal heterogeneity in glioblastoma: moving targets in recurrent versus primary tumors
Niklas Schäfer, Gerrit H. Gielen, Laurèl Rauschenbach, Sied Kebir, Andreas Till, Roman Reinartz, Matthias Simon, Pitt Niehusmann, Christoph Kleinschnitz, Ulrich Herrlinger, Torsten Pietsch, Björn Scheffler, Martin Glas
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A nomogram to predict survival in non-small cell lung cancer patients treated with nivolumab
Andrea Botticelli, Massimiliano Salati, Francesca Romana Di Pietro, Lidia Strigari, Bruna Cerbelli, Ilaria Grazia Zizzari, Raffaele Giusti, Marco Mazzotta, Federica Mazzuca, Michela Roberto, Patrizia Vici, Laura Pizzuti, Marianna Nuti, Paolo Marchetti
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Delivery of oncolytic vaccinia virus by matched allogeneic stem cells overcomes critical innate and adaptive immune barriers
Dobrin D. Draganov, Antonio F. Santidrian, Ivelina Minev, Duong Nguyen, Mehmet Okyay Kilinc, Ivan Petrov, Anna Vyalkova, Elliot Lander, Mark Berman, Boris Minev, Aladar A. Szalay
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Genetic polymorphisms of histone methyltransferase SETD2 predicts prognosis and chemotherapy response in Chinese acute myeloid leukemia patients
Suwei Wang, Xiaoqing Yuan, Yazhen Liu, Kewei Zhu, Peng Chen, Han Yan, Daoyu Zhang, Xi Li, Hui Zeng, Xielan Zhao, Xiaoping Chen, Gan Zhou, Shan Cao
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia
Zi-jun Xu, Ji-chun Ma, Jing-dong Zhou, Xiang-mei Wen, Dong-ming Yao, Wei Zhang, Run-bi Ji, De-hong Wu, Li-juan Tang, Zhao-qun Deng, Jun Qian, Jiang Lin
01.12.2019 | Research | Ausgabe 1/2019
Open Access
High expression of miR-363 predicts poor prognosis and guides treatment selection in acute myeloid leukemia
Huihui Zhang, Ninghan Zhang, Rong Wang, Tingting Shao, Yuan Feng, Yao Yao, Qingyun Wu, Shengyun Zhu, Jiang Cao, Huanxin Zhang, Zhenyu Li, Xuejiao Liu, Mingshan Niu, Kailin Xu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Monoallelic expression in melanoma
Lee Silcock, Hakeem Almabrazi, Younes Mokrab, Puthen Jithesh, Muna Al-Hashmi, Nicola James, Rebecca Mathew, Valentina Mattei, Davide Bedognetti, Francesca Lessi, Ramzi Temanni, Barbara Seliger, Rashid Al-Ali, Francesco M. Marincola, Ena Wang, Sara Tomei
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Interleukin 32 expression in human melanoma
Helicia Paz, Jennifer Tsoi, Anusha Kalbasi, Catherine S. Grasso, William H. McBride, Dörthe Schaue, Lisa H. Butterfield, Deena M. Maurer, Antoni Ribas, Thomas G. Graeber, James S. Economou
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Clusterin silencing restores myoblasts viability and down modulates the inflammatory process in osteoporotic disease
S. Pucci, C. Greggi, C. Polidoro, M. C. Piro, M. Celi, M. Feola, E. Gasbarra, R. Iundusi, F. Mastrangeli, G. Novelli, A. Orlandi, U. Tarantino
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Compound α-keto acid tablet supplementation alleviates chronic kidney disease progression via inhibition of the NF-kB and MAPK pathways
Meng Wang, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Li Li, Hui Gao, Zhi Zhao, Fan Zhu, Han Zhu, Wangqun Liang, Kun Qian, Chunxiu Zhang, Rui Zeng, Hanjing Zhou, Ying Yao
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Contribution of BRCA1 5382insC mutation in triple negative breast cancer in Tunisia
Wijden Mahfoudh, Inchirah Bettaieb, Randa Ghedira, Kaouther Snoussi, Nadia Bouzid, Zahra Klayech, Sallouha Gabbouj, Yassmine Remadi, Elham Hassen, Noureddine Bouaouina, Abdelfateh Zakhama
01.12.2019 | Research | Ausgabe 1/2019
Open Access
An enrichment method to increase cell-free fetal DNA fraction and significantly reduce false negatives and test failures for non-invasive prenatal screening: a feasibility study
Ping Hu, Dong Liang, Yangyi Chen, Ying Lin, Fengchang Qiao, Hang Li, Ting Wang, Chunfang Peng, Donghong Luo, Hailiang Liu, Zhengfeng Xu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer
Aruz Mesci, Fabrice Lucien, Xiaoyong Huang, Eric H. Wang, David Shin, Michelle Meringer, Christianne Hoey, Jessica Ray, Paul C. Boutros, Hon S. Leong, Stanley K. Liu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation
Alex Ali Sayour, Sevil Korkmaz-Icöz, Sivakkanan Loganathan, Mihály Ruppert, Viktor Nabil Sayour, Attila Oláh, Kálmán Benke, Maik Brune, Rita Benkő, Eszter Mária Horváth, Matthias Karck, Béla Merkely, Tamás Radovits, Gábor Szabó
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Bone marrow donor selection and characterization of MSCs is critical for pre-clinical and clinical cell dose production
Alpa Trivedi, Byron Miyazawa, Stuart Gibb, Kristen Valanoski, Lindsay Vivona, Maximillian Lin, Daniel Potter, Mars Stone, Philip J. Norris, James Murphy, Sawyer Smith, Martin Schreiber, Shibani Pati
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy
Matteo Pallocca, Davide Angeli, Fabio Palombo, Francesca Sperati, Michele Milella, Frauke Goeman, Francesca De Nicola, Maurizio Fanciulli, Paola Nisticò, Concetta Quintarelli, Gennaro Ciliberto
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Remote ischemic preconditioning attenuates intestinal mucosal damage: insight from a rat model of ischemia–reperfusion injury
Lars Hummitzsch, Karina Zitta, Rouven Berndt, Yuk Lung Wong, Rene Rusch, Katharina Hess, Thilo Wedel, Matthias Gruenewald, Jochen Cremer, Markus Steinfath, Martin Albrecht
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Clinico-pathological associations and concomitant mutations of the RAS/RAF pathway in metastatic colorectal cancer
Edoardo Isnaldi, Anna Garuti, Gabriella Cirmena, Stefano Scabini, Edoardo Rimini, Lorenzo Ferrando, Michela Lia, Roberto Murialdo, Lucia Tixi, Enrico Carminati, Andrea Panaro, Maurizio Gallo, Federica Grillo, Luca Mastracci, Lazzaro Repetto, Roberto Fiocca, Emanuele Romairone, Gabriele Zoppoli, Alberto Ballestrero
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A circulating miRNA signature for early diagnosis of acute kidney injury following acute myocardial infarction
Pei-Chun Fan, Chia-Chun Chen, Chen-Ching Peng, Chih-Hsiang Chang, Chia-Hung Yang, Chi Yang, Lichieh Julie Chu, Yung-Chang Chen, Chih-Wei Yang, Yu-Sun Chang, Pao-Hsien Chu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
SOX9 drives the epithelial–mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway
Jing-Qiang Huang, Fa-Kai Wei, Xiu-Li Xu, Shi-Xing Ye, Jun-Wei Song, Pei-Kun Ding, Jing Zhu, He-Feng Li, Xin-Ping Luo, Hui Gong, Li Su, Lin Yang, Li-Yun Gong
01.12.2019 | Meeting report | Ausgabe 1/2019
Open Access
The great debate at “Melanoma Bridge 2018”, Naples, December 1st, 2018
Paolo A. Ascierto, Paolo Bruzzi, Alexander Eggermont, Omid Hamid, Hussein A. Tawbi, Alexander van Akkooi, Alessandro Testori, Corrado Caracò, Igor Puzanov, Francesco Perrone
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Values of integration between lipidomics and clinical phenomes in patients with acute lung infection, pulmonary embolism, or acute exacerbation of chronic pulmonary diseases: a preliminary study
Danyan Gao, Linlin Zhang, Dongli Song, Jiapei Lv, Linyan Wang, Shuang Zhou, Yanjun Li, Tao Zeng, Yiming Zeng, Jiaqiang Zhang, Xiangdong Wang
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia
Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts, Ashok Saluja
01.12.2019 | Research | Ausgabe 1/2019
Open Access
High NCALD expression predicts poor prognosis of cytogenetic normal acute myeloid leukemia
Ying Song, Weilong Zhang, Xue He, Xiaoni Liu, Ping Yang, Jing Wang, Kai Hu, Weiyou Liu, Xiuru Zhang, Hongmei Jing, Xiaoliang Yuan
01.12.2019 | Review | Ausgabe 1/2019
Open Access
Why primary obesity is a disease?
Antonino De Lorenzo, Santo Gratteri, Paola Gualtieri, Andrea Cammarano, Pierfrancesco Bertucci, Laura Di Renzo
01.12.2019 | Review | Ausgabe 1/2019
Open Access
Biobanking in health care: evolution and future directions
Luigi Coppola, Alessandra Cianflone, Anna Maria Grimaldi, Mariarosaria Incoronato, Paolo Bevilacqua, Francesco Messina, Simona Baselice, Andrea Soricelli, Peppino Mirabelli, Marco Salvatore
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Circulating miRNAs as non-invasive biomarkers to predict aggressive prostate cancer after radical prostatectomy
C. Hoey, M. Ahmed, A. Fotouhi Ghiam, D. Vesprini, X. Huang, K. Commisso, A. Commisso, J. Ray, E. Fokas, D. A. Loblaw, H. H. He, S. K. Liu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Identification of two microRNA signatures in whole blood as novel biomarkers for diagnosis of nasopharyngeal carcinoma
Wen Wen, Shi-Juan Mai, Huan-Xin Lin, Mei-Yin Zhang, Jia-Ling Huang, Xin Hua, Chao Lin, Zhi-Qing Long, Zi-Jian Lu, Xiao-Qing Sun, Sai-Lan Liu, Qi Yang, Qian Zhu, Hui-Yun Wang, Ling Guo
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Mutational landscape of gastric cancer and clinical application of genomic profiling based on target next-generation sequencing
Hui Cai, Changqing Jing, Xusheng Chang, Dan Ding, Ting Han, Junchi Yang, Zhengmao Lu, Xuguang Hu, Zhaorui Liu, Jinshen Wang, Liang Shang, Shouxin Wu, Peng Meng, Ling Lin, Jiangman Zhao, Mingming Nie, Kai Yin
01.12.2019 | Research | Ausgabe 1/2019
Open Access
High IL2RA mRNA expression is an independent adverse prognostic biomarker in core binding factor and intermediate-risk acute myeloid leukemia
Wen Du, Jing He, Wei Zhou, Simin Shu, Juan Li, Wei Liu, Yun Deng, Cong Lu, Shengyan Lin, Yaokun Ma, Yanli He, Jine Zheng, Jiang Zhu, Lijuan Bai, Xiaoqing Li, Junxia Yao, Dan Hu, Shengqing Gu, Huiyu Li, Anyuan Guo, Shiang Huang, Xiaolan Feng, Dong Hu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Regulatory T cells and M2 macrophages present diverse prognostic value in gastric cancer patients with different clinicopathologic characteristics and chemotherapy strategies
Xu Liu, Danhua Xu, Chen Huang, Yixian Guo, Shuchang Wang, Chunchao Zhu, Jia Xu, Zizhen Zhang, Yanying Shen, Wenyi Zhao, Gang Zhao
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine
Ho Joong Choi, Suk Joon Cho, Ok-Hee Kim, Jin Sook Song, Ha-Eun Hong, Sang Chul Lee, Kee-Hwan Kim, Sang Kuon Lee, Young Kyoung You, Tae Ho Hong, Eun Young Kim, Jung Hyun Park, Gun Hyung Na, Dong Do You, Jae Hyun Han, Jae Woo Park, Bong Jun Kwak, Tae Yun Lee, Joseph Ahn, Hwan Hee Lee, Seung Kyu Kang, Kyu-Seok Hwang, Jae-Kyung Jung, Kwan-Young Jung, Say-June Kim
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Discriminant analysis and machine learning approach for evaluating and improving the performance of immunohistochemical algorithms for COO classification of DLBCL
Yocanxóchitl Perfecto-Avalos, Alejandro Garcia-Gonzalez, Ana Hernandez-Reynoso, Gildardo Sánchez-Ante, Carlos Ortiz-Hidalgo, Sean-Patrick Scott, Rita Q. Fuentes-Aguilar, Ricardo Diaz-Dominguez, Grettel León-Martínez, Verónica Velasco-Vales, Mara A. Cárdenas-Escudero, José A. Hernández-Hernández, Arturo Santos, José R. Borbolla-Escoboza, Luis Villela
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Platelet count, aspirin use, and characteristics of host inflammatory responses in colorectal cancer
Juha P. Väyrynen, Sara A. Väyrynen, Päivi Sirniö, Ilkka Minkkinen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J. Karttunen, Anne Tuomisto, Markus J. Mäkinen
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Development and validation of a new tumor-based gene signature predicting prognosis of HBV/HCV-included resected hepatocellular carcinoma patients
Gui-Qi Zhu, Yi Yang, Er-Bao Chen, Biao Wang, Kun Xiao, Shi-Ming Shi, Zheng-Jun Zhou, Shao-Lai Zhou, Zheng Wang, Ying-Hong Shi, Jia Fan, Jian Zhou, Tian-Shu Liu, Zhi Dai
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Development of a novel ssDNA aptamer targeting neutrophil gelatinase-associated lipocalin and its application in clinical trials
Xiaoqian Hong, Huihui Yan, Fuan Xie, Kaiyu Wang, Qiang Wang, Huijuan Huang, Kunrong Yang, Suhong Huang, Tingting Zhao, Junkai Wang, Yunyun Chen, Kuancan Liu, Xiaopeng Lan
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Unilateral L4-dorsal root ganglion stimulation evokes pain relief in chronic neuropathic postsurgical knee pain and changes of inflammatory markers: part II whole transcriptome profiling
Thomas M. Kinfe, Maria Asif, Krishnan V. Chakravarthy, Timothy R. Deer, Jeffery M. Kramer, Thomas L. Yearwood, Rene Hurlemann, Muhammad Sajid Hussain, Susanne Motameny, Prerana Wagle, Peter Nürnberg, Sascha Gravius, Thomas Randau, Nadine Gravius, Shafqat R. Chaudhry, Sajjad Muhammad
01.12.2019 | Research | Ausgabe 1/2019
Open Access
PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma
Yui Hirata-Nozaki, Takayuki Ohkuri, Kenzo Ohara, Takumi Kumai, Marino Nagata, Shohei Harabuchi, Akemi Kosaka, Toshihiro Nagato, Kei Ishibashi, Kensuke Oikawa, Naoko Aoki, Mizuho Ohara, Yasuaki Harabuchi, Yuji Uno, Hidehiro Takei, Esteban Celis, Hiroya Kobayashi
01.12.2019 | Research | Ausgabe 1/2019
Open Access
EV-associated miRNAs from peritoneal lavage as potential diagnostic biomarkers in colorectal cancer
Berta Roman-Canal, Jordi Tarragona, Cristian Pablo Moiola, Sònia Gatius, Sarah Bonnin, Maria Ruiz-Miró, José Enrique Sierra, Maria Rufas, Esperanza González, José M. Porcel, Antonio Gil-Moreno, Juan M. Falcón-Pérez, Julia Ponomarenko, Xavier Matias-Guiu, Eva Colas
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Identification of novel pathogenic MSH2 mutation and new DNA repair genes variants: investigation of a Tunisian Lynch syndrome family with discordant twins
Amira Jaballah-Gabteni, Haifa Tounsi, Maria Kabbage, Yosr Hamdi, Sahar Elouej, Ines Ben Ayed, Mouna Medhioub, Moufida Mahmoudi, Hamza Dallali, Hamza Yaiche, Nadia Ben Jemii, Afifa Maaloul, Najla Mezghani, Sonia Abdelhak, Lamine Hamzaoui, Mousaddak Azzouz, Samir Boubaker
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients
Xiao-Qing Yuan, Peng Chen, Yin-Xiao Du, Ke-Wei Zhu, Dao-Yu Zhang, Han Yan, Han Liu, Yan-Ling Liu, Shan Cao, Gan Zhou, Hui Zeng, Shu-Ping Chen, Xie-Lan Zhao, Jing Yang, Wen-Jing Zeng, Xiao-Ping Chen
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy
Mária Lódi, Dániel Priksz, Gábor Áron Fülöp, Beáta Bódi, Alexandra Gyöngyösi, Lilla Nagy, Árpád Kovács, Attila Béla Kertész, Judit Kocsis, István Édes, Zoltán Csanádi, István Czuriga, Zoltán Kisvárday, Béla Juhász, István Lekli, Péter Bai, Attila Tóth, Zoltán Papp, Dániel Czuriga
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Cholesterol efflux alterations in adolescent obesity: role of adipose-derived extracellular vesical microRNAs
Matthew D. Barberio, Lora J. Kasselman, Martin P. Playford, Samuel B. Epstein, Heather A. Renna, Madeleine Goldberg, Joshua DeLeon, Iryna Voloshyna, Ashley Barlev, Michael Salama, Sarah C. Ferrante, Evan P. Nadler, Nehal Mehta, Allison B. Reiss, Robert J. Freishtat
01.12.2019 | Meeting report | Ausgabe 1/2019
Open Access
Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th–1 December 1st, 2018, Naples, Italy)
Paolo A. Ascierto, Sanjiv S. Agarwala, Gerardo Botti, Alfredo Budillon, Michael A. Davies, Reinhard Dummer, Marc Ernstoff, Soldano Ferrone, Silvia Formenti, Thomas F. Gajewski, Claus Garbe, Omid Hamid, Roger S. Lo, Jason J. Luke, Oliver Michielin, Giuseppe Palmieri, Laurence Zitvogel, Francesco M. Marincola, Giuseppe Masucci, Corrado Caracò, Magdalena Thurin, Igor Puzanov
01.12.2019 | Research | Ausgabe 1/2019
Open Access
PCR-based zebrafish model for personalised medicine in head and neck cancer
Ahmed Al-Samadi, Katja Tuomainen, Anne Kivimäki, Abdelhakim Salem, Sakhr Al-Kubati, Aini Hyytiäinen, Mataleena Parikka, Karri Mesimäki, Tommy Wilkman, Antti Mäkitie, Reidar Grenman, Tuula Salo
01.12.2019 | Research | Ausgabe 1/2019
Open Access
European mitochondrial haplogroups predict liver-related outcomes in patients coinfected with HIV and HCV: a retrospective study
Teresa Aldámiz-Echevarría, Salvador Resino, José M. Bellón, María A. Jiménez-Sousa, Pilar Miralles, Luz M. Medrano, Ana Carrero, Cristina Díez, Leire Pérez-Latorre, Chiara Fanciulli, Pilar Garcia-Broncano, Juan Berenguer
01.12.2019 | Research | Ausgabe 1/2019
Open Access
In vivo model of human post-traumatic heterotopic ossification demonstrates early fibroproliferative signature
Jaira F. de Vasconcellos, Sonia Zicari, Stephen D. Fernicola, Daniel W. Griffin, Youngmi Ji, Emily H. Shin, Patrick Jones, Gregory T. Christopherson, Husain Bharmal, Carl Cirino, Thao Nguyen, Astor Robertson, Vincent D. Pellegrini Jr., Leon J. Nesti
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Regulatory T cells from patients with end-stage organ disease can be isolated, expanded and cryopreserved according good manufacturing practice improving their function
Francesca Ulbar, Tiziana Montemurro, Tatiana Jofra, Miriam Capri, Giorgia Comai, Valentina Bertuzzo, Cristiana Lavazza, Alessandra Mandelli, Mariele Viganò, Silvia Budelli, Maria Giulia Bacalini, Chiara Pirazzini, Paolo Garagnani, Valeria Giudice, Daria Sollazzo, Antonio Curti, Mario Arpinati, Gaetano La Manna, Matteo Cescon, Antonio Daniele Pinna, Claudio Franceschi, Manuela Battaglia, Rosaria Giordano, Lucia Catani, Roberto Massimo Lemoli
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer
Dan Wang, Weitang Yuan, Yaping Wang, Qian Wu, Li Yang, Feng Li, Xinfeng Chen, Zhen Zhang, Weina Yu, Nomathamsanqa Resegofetse Maimela, Ling Cao, Dong Wang, Junxia Wang, Zhenqiang Sun, Jinbo Liu, Yi Zhang
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Identifying subpathway signatures for individualized anticancer drug response by integrating multi-omics data
Yanjun Xu, Qun Dong, Feng Li, Yingqi Xu, Congxue Hu, Jingwen Wang, Desi Shang, Xuan Zheng, Haixiu Yang, Chunlong Zhang, Mengting Shao, Mohan Meng, Zhiying Xiong, Xia Li, Yunpeng Zhang
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats
Lei Ding, Ying Kang, Hang-Bing Dai, Fang-Zheng Wang, Hong Zhou, Qing Gao, Xiao-Qing Xiong, Feng Zhang, Tian-Run Song, Yan Yuan, Ming Liu, Guo-Qing Zhu, Ye-Bo Zhou
01.12.2019 | Research | Ausgabe 1/2019
Open Access
SNORD89 promotes stemness phenotype of ovarian cancer cells by regulating Notch1-c-Myc pathway
Wenjing Zhu, Jumin Niu, Miao He, Liwen Zhang, Xuemei Lv, Fangxiao Liu, Longyang Jiang, Jing Zhang, Zhaojin Yu, Lin Zhao, Jia Bi, Yuanyuan Yan, Qian Wei, Hong Huo, Yue Fan, Yuzong Chen, Jian Ding, Minjie Wei
01.12.2019 | Review | Ausgabe 1/2019
Open Access
New paradigm for stage III melanoma: from surgery to adjuvant treatment
Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli, Corrado Caracò
01.12.2019 | Research | Ausgabe 1/2019
Open Access
miR-21 induces endothelial progenitor cells proliferation and angiogenesis via targeting FASLG and is a potential prognostic marker in deep venous thrombosis
Xiaolong Du, Lei Hong, Lili Sun, Hongfei Sang, Aiming Qian, Wendong Li, Hao Zhuang, Huoqi Liang, Dandan Song, Chenglong Li, Wenbin Wang, Xiaoqiang Li
01.12.2019 | Research | Ausgabe 1/2019
Open Access
First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells
Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield, Aladar A. Szalay
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma
Yu Jin, Wai Yeow Lee, Soo Ting Toh, Chandana Tennakoon, Han Chong Toh, Pierce Kah-Hoe Chow, Alexander Y.-F. Chung, Samuel S. Chong, London L.-P.-J. Ooi, Wing-Kin Sung, Caroline G.-L. Lee
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A novel CD147 inhibitor, SP-8356, reduces neointimal hyperplasia and arterial stiffness in a rat model of partial carotid artery ligation
Kisoo Pahk, Hyojin Noh, Chanmin Joung, Mi Jang, Hwa Young Song, Kyung Won Kim, Kihoon Han, Jong-Ik Hwang, Sungeun Kim, Won-Ki Kim
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis
Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao, Yu Peng
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Diagnosing enterovirus meningitis via blood transcriptomics: an alternative for lumbar puncture?
Esther Bartholomeus, Nicolas De Neuter, Annelies Lemay, Luc Pattyn, David Tuerlinckx, David Weynants, Koen Van Lede, Gerlant van Berlaer, Dominique Bulckaert, Tine Boiy, Ann Vander Auwera, Marc Raes, Dimitri Van der Linden, Helene Verhelst, Susanne Van Steijn, Tijl Jonckheer, Joke Dehoorne, Rik Joos, Hilde Jansens, Arvid Suls, Pierre Van Damme, Kris Laukens, Geert Mortier, Pieter Meysman, Benson Ogunjimi
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A randomized, placebo-controlled, double-blinded, single-centre, phase IV trial to assess the efficacy and safety of OM-85 in children suffering from recurrent respiratory tract infections
Susanna Esposito, Sonia Bianchini, Samantha Bosis, Claudia Tagliabue, Ilaria Coro, Alberto Argentiero, Nicola Principi
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach
Antonella Manca, Panagiotis Paliogiannis, Maria Colombino, Milena Casula, Amelia Lissia, Gerardo Botti, Corrado Caracò, Paolo A. Ascierto, Maria Cristina Sini, Grazia Palomba, Marina Pisano, Valentina Doneddu, Antonio Cossu, Giuseppe Palmieri, Melanoma Unit of Sassari (MUS), Italian Association for Cancer Research (AIRC) Study Group, for the Italian Melanoma Intergroup (IMI)
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets
Jie Feng, Hua Gao, Qi Zhang, Yang Zhou, Chuzhong Li, Sida Zhao, Lichuan Hong, Jinjin Yang, Shuyu Hao, Wan Hong, Zhengping Zhuang, Guowang Xu, Yazhuo Zhang
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Incidence and risk factors of early HCC occurrence in HCV patients treated with direct acting antivirals: a prospective multicentre study
Luca Rinaldi, Alessandro Perrella, Maria Guarino, Massimo De Luca, Guido Piai, Nicola Coppola, Pia Clara Pafundi, Fortunato Ciardiello, Morena Fasano, Erika Martinelli, Giovanna Valente, Riccardo Nevola, Caterina Monari, Lucia Miglioresi, Barbara Guerrera, Massimiliano Berretta, Ferdinando Carlo Sasso, Filomena Morisco, Antonio Izzi, Luigi Elio Adinolfi
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Selective improvement by rifaximin of changes in the immunophenotype in patients who improve minimal hepatic encephalopathy
Alba Mangas-Losada, Raquel García-García, Paola Leone, María Pilar Ballester, Andrea Cabrera-Pastor, Amparo Urios, Juan-José Gallego, Juan-José Martínez-Pretel, Carla Giménez-Garzó, Fernando Revert, Desamparados Escudero-García, Joan Tosca, María Pilar Ríos, Cristina Montón, Lucia Durbán, Luis Aparicio, Carmina Montoliu, Vicente Felipo
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Second line therapy with axitinib after only prior sunitinib in metastatic renal cell cancer: Italian multicenter real world SAX study final results
Gaetano Facchini, Sabrina Rossetti, Massimiliano Berretta, Carla Cavaliere, Sarah Scagliarini, Maria Giuseppa Vitale, Chiara Ciccarese, Giuseppe Di Lorenzo, Erica Palesandro, Vincenza Conteduca, Umberto Basso, Emanuele Naglieri, Azzurra Farnesi, Michele Aieta, Nicolò Borsellino, Leonardo La Torre, Gelsomina Iovane, Lucia Bonomi, Donatello Gasparro, Enrico Ricevuto, Michele De Tursi, Rocco De Vivo, Giovanni Lo Re, Francesco Grillone, Paolo Marchetti, Ferdinando De Vita, Claudio Scavelli, Claudio Sini, Salvatore Pisconti, Anna Crispo, Vittorio Gebbia, Antonio Maestri, Luca Galli, Ugo De Giorgi, Roberto Iacovelli, Carlo Buonerba, Giacomo Cartenì, Carmine D’Aniello
01.12.2019 | Research | Ausgabe 1/2019
Open Access
TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding
Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang, Qiang Shu
01.12.2019 | Correction | Ausgabe 1/2019
Open Access
Correction to: Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia
Bhuwan Giri, Vineet K. Gupta, Brianna Yaffe, Shrey Modi, Pooja Roy, Vrishketan Sethi, Shweta P. Lavania, Selwyn M. Vickers, Vikas Dudeja, Sulagna Banerjee, Justin Watts, Ashok Saluja
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Undetectable circulating tumor DNA (ctDNA) levels correlate with favorable outcome in metastatic melanoma patients treated with anti-PD1 therapy
Teofila Seremet, Yanina Jansen, Simon Planken, Hassan Njimi, Mélanie Delaunoy, Hakim El Housni, Gil Awada, Julia Katharina Schwarze, Marleen Keyaerts, Hendrik Everaert, Danielle Lienard, Véronique Del Marmol, Pierre Heimann, Bart Neyns
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Plasma concentration and expression of adipokines in epicardial and subcutaneous adipose tissue are associated with impaired left ventricular filling pattern
Kacper Toczylowski, Tomasz Hirnle, Dorota Harasiuk, Piotr Zabielski, Anna Lewczuk, Iwona Dmitruk, Monika Ksiazek, Artur Sulik, Jan Gorski, Adrian Chabowski, Marcin Baranowski
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Identification of key DNA methylation-driven genes in prostate adenocarcinoma: an integrative analysis of TCGA methylation data
Ning Xu, Yu-Peng Wu, Zhi-Bin Ke, Ying-Chun Liang, Hai Cai, Wen-Ting Su, Xuan Tao, Shao-Hao Chen, Qing-Shui Zheng, Yong Wei, Xue-Yi Xue
01.12.2019 | Methodology | Ausgabe 1/2019
Open Access
Discrimination of indoor versus outdoor environmental state with machine learning algorithms in myopia observational studies
Bin Ye, Kangping Liu, Siting Cao, Padmaja Sankaridurg, Wayne Li, Mengli Luan, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu, Xiangui He
01.12.2019 | Correction | Ausgabe 1/2019
Open Access
Correction to: New paradigm for stage III melanoma: from surgery to adjuvant treatment
Paolo Antonio Ascierto, Lorenzo Borgognoni, Gerardo Botti, Michele Guida, Paolo Marchetti, Simone Mocellin, Paolo Muto, Giuseppe Palmieri, Roberto Patuzzo, Pietro Quaglino, Ignazio Stanganelli, Corrado Caracò
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization
Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin Pei, Eric S. Yvon, Eugene I. Hwang, Catherine M. Bollard, Javad Nazarian, Conrad Russell Y. Cruz
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Predictive model for acute respiratory distress syndrome events in ICU patients in China using machine learning algorithms: a secondary analysis of a cohort study
Xian-Fei Ding, Jin-Bo Li, Huo-Yan Liang, Zong-Yu Wang, Ting-Ting Jiao, Zhuang Liu, Liang Yi, Wei-Shuai Bian, Shu-Peng Wang, Xi Zhu, Tong-Wen Sun
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Circulating DNA as prognostic biomarker in patients with advanced hepatocellular carcinoma: a translational exploratory study from the SORAMIC trial
Marianna Alunni-Fabbroni, Kerstin Rönsch, Thomas Huber, Clemens C. Cyran, Max Seidensticker, Julia Mayerle, Maciej Pech, Bristi Basu, Chris Verslype, Julia Benckert, Peter Malfertheiner, Jens Ricke
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Pathogenicity of new BEST1 variants identified in Italian patients with best vitelliform macular dystrophy assessed by computational structural biology
Vladimir Frecer, Giancarlo Iarossi, Anna Paola Salvetti, Paolo Enrico Maltese, Giulia Delledonne, Marta Oldani, Giovanni Staurenghi, Benedetto Falsini, Angelo Maria Minnella, Lucia Ziccardi, Adriano Magli, Leonardo Colombo, Fabiana D’Esposito, Jan Miertus, Francesco Viola, Marcella Attanasio, Emilia Maggio, Matteo Bertelli
01.12.2019 | Research | Ausgabe 1/2019
Open Access
90-gene signature assay for tissue origin diagnosis of brain metastases
Yulong Zheng, Yongfeng Ding, Qifeng Wang, Yifeng Sun, Xiaodong Teng, Qiqi Gao, Weixiang Zhong, Xiaofeng Lou, Cheng Xiao, Chengshu Chen, Qinghua Xu, Nong Xu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Plasma peroxiredoxin changes and inflammatory cytokines support the involvement of neuro-inflammation and oxidative stress in Autism Spectrum Disorder
P. M. Abruzzo, A. Matté, A. Bolotta, E. Federti, A. Ghezzo, T. Guarnieri, M. Marini, A. Posar, A. Siciliano, L. De Franceschi, P. Visconti
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Tracking longitudinal genetic changes of circulating tumor DNA (ctDNA) in advanced Lung adenocarcinoma treated with chemotherapy
Xiaohong Han, Ying Han, Qiaoyun Tan, Yu Huang, Jianliang Yang, Sheng Yang, Xiaohui He, Shengyu Zhou, Yan Song, Jinping Pi, Lijie Zuo, Jiarui Yao, Di Wu, Zhishang Zhang, Yuankai Shi
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development
Wil Lieberman-Cribbin, Stephanie Tuminello, Christina Gillezeau, Maaike van Gerwen, Rachel Brody, David J. Mulholland, Lori Horton, Maureen Sisco, Colette Prophete, Judith Zelikoff, Hyun-Wook Lee, Sung-Hyun Park, Lung-Chi Chen, Mitchell D. Cohen, Emanuela Taioli
01.12.2019 | Protocol | Ausgabe 1/2019
Open Access
The natural course of unruptured intracranial aneurysms in a Chinese cohort: protocol of a multi-center registration study in CIAP
Haixiao Liu, Wei Guo, Sishi Xiang, Peng Hu, Feifei Sun, Junmei Gao, Xiaoyang Zhang, Ping Wang, Wenting Jing, Lei Zhang, Xinjian Yang, Chuanzhi Duan, Min He, Hongqi Zhang, Yan Qu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Mild hyperthermia by MR-guided focused ultrasound in an ex vivo model of osteolytic bone tumour: optimization of the spatio-temporal control of the delivered temperature
Pauline C. Guillemin, Laura Gui, Orane Lorton, Thomas Zilli, Lindsey A. Crowe, Stéphane Desgranges, Xavier Montet, Sylvain Terraz, Raymond Miralbell, Rares Salomir, Sana Boudabbous
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Clinical significance of PD-L1 expression in serum-derived exosomes in NSCLC patients
Chuling Li, Chuwei Li, Chunchun Zhi, Wenjun Liang, Xuan Wang, Xi Chen, Tangfeng Lv, Qin Shen, Yong Song, Dang Lin, Hongbing Liu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
The tumor inflammation signature (TIS) is associated with anti-PD-1 treatment benefit in the CERTIM pan-cancer cohort
Diane Damotte, Sarah Warren, Jennifer Arrondeau, Pascaline Boudou-Rouquette, Audrey Mansuet-Lupo, Jérôme Biton, Hanane Ouakrim, Marco Alifano, Claire Gervais, Audrey Bellesoeur, Nora Kramkimel, Camille Tlemsani, Barbara Burroni, Angéline Duche, Franck Letourneur, Han Si, Rebecca Halpin, Todd Creasy, Ronald Herbst, Xing Ren, Pascale Morel, Alessandra Cesano, François Goldwasser, Karen Leroy
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy
Salvatore Venosi, Giancarlo Ceccarelli, Massimiliano de Angelis, Luca Laghi, Laura Bianchi, Ombretta Martinelli, Debora Maruca, Eugenio Nelson Cavallari, Fabrizia Toscanella, Paolo Vassalini, Vito Trinchieri, Alessandra Oliva, Gabriella d’Ettorre
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Decreased plasma phospholipid concentrations and increased acid sphingomyelinase activity are accurate biomarkers for community-acquired pneumonia
Haroon Arshad, Juan Carlos López Alfonso, Raimo Franke, Katina Michaelis, Leonardo Araujo, Aamna Habib, Yuliya Zboromyrska, Eva Lücke, Emilia Strungaru, Manas K. Akmatov, Haralampos Hatzikirou, Michael Meyer-Hermann, Astrid Petersmann, Matthias Nauck, Mark Brönstrup, Ursula Bilitewski, Laurent Abel, Jorg Sievers, Jordi Vila, Thomas Illig, Jens Schreiber, Frank Pessler
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Circulating PCSK9 and cardiovascular events in FH patients with standard lipid-lowering therapy
Ye-Xuan Cao, Jing-Lu Jin, Di Sun, Hui-Hui Liu, Yuan-Lin Guo, Na-Qiong Wu, Rui-Xia Xu, Cheng-Gang Zhu, Qian Dong, Jing Sun, Jian-Jun Li
01.12.2019 | Review | Ausgabe 1/2019
Open Access
In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network
Margalida Esteva-Socias, María-Jesús Artiga, Olga Bahamonde, Oihana Belar, Raquel Bermudo, Erika Castro, Teresa Escámez, Máximo Fraga, Laura Jauregui-Mosquera, Isabel Novoa, Lorena Peiró-Chova, Juan-David Rejón, María Ruiz-Miró, Paula Vieiro-Balo, Virginia Villar-Campo, Sandra Zazo, Alberto Rábano, Cristina Villena
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia
Andrea Rzepiel, Nóra Kutszegi, András Gézsi, Judit C. Sági, Bálint Egyed, György Péter, Henriett Butz, Gábor Nyírő, Judit Müller, Gábor T. Kovács, Csaba Szalai, Ágnes F. Semsei, Dániel J. Erdélyi
01.12.2019 | Methodology | Ausgabe 1/2019
Open Access
The OncoLifeS data-biobank for oncology: a comprehensive repository of clinical data, biological samples, and the patient’s perspective
Grigory Sidorenkov, Janny Nagel, Coby Meijer, Jacko J. Duker, Harry J. M. Groen, Gyorgy B. Halmos, Maaike H. M. Oonk, Rene J. Oostergo, Bert van der Vegt, Max J. H. Witjes, Marcel Nijland, Klaas Havenga, John H. Maduro, Jourik A. Gietema, Gertruida H. de Bock
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis
Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Early fatigue in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: an insight from clinical practice
Alessio Cortellini, Maria G. Vitale, Federica De Galitiis, Francesca R. Di Pietro, Rossana Berardi, Mariangela Torniai, Michele De Tursi, Antonino Grassadonia, Pietro Di Marino, Daniele Santini, Tea Zeppola, Cecilia Anesi, Alain Gelibter, Mario Alberto Occhipinti, Andrea Botticelli, Paolo Marchetti, Francesca Rastelli, Federica Pergolesi, Marianna Tudini, Rosa Rita Silva, Domenico Mallardo, Vito Vanella, Corrado Ficorella, Giampiero Porzio, Paolo A. Ascierto
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Atheroprotective effects of methotrexate via the inhibition of YAP/TAZ under disturbed flow
Dandan Liu, Hang Lv, Qi Liu, Yanli Sun, Shenglong Hou, Lu Zhang, Mengyue Yang, Baihe Han, Gang wang, Xuedong Wang, Wenjuan Du, Honggang Nie, Ruoxi Zhang, Xingtao Huang, Jingbo Hou, Bo Yu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
A prospective evaluation of thiamine and magnesium status in relation to clinicopathological characteristics and 1-year mortality in patients with alcohol withdrawal syndrome
Donogh Maguire, Dinesh Talwar, Alana Burns, Anthony Catchpole, Fiona Stefanowicz, Gordon Robson, David P. Ross, David Young, Alastair Ireland, Ewan Forrest, Peter Galloway, Michael Adamson, Eoghan Colgan, Hannah Bell, Lesley Orr, Joanna-Lee Kerr, Xen Roussis, Donald C. McMillan
01.12.2019 | Protocol | Ausgabe 1/2019
Open Access
Mining multi-site clinical data to develop machine learning MRI biomarkers: application to neonatal hypoxic ischemic encephalopathy
Rebecca J. Weiss, Sara V. Bates, Ya’nan Song, Yue Zhang, Emily M. Herzberg, Yih-Chieh Chen, Maryann Gong, Isabel Chien, Lily Zhang, Shawn N. Murphy, Randy L. Gollub, P. Ellen Grant, Yangming Ou
01.12.2019 | Research | Ausgabe 1/2019
Open Access
BMI, irAE, and gene expression signatures associate with resistance to immune-checkpoint inhibition and outcomes in renal cell carcinoma
Brian W. Labadie, Ping Liu, Riyue Bao, Michael Crist, Ricardo Fernandes, Laura Ferreira, Scott Graupner, Andrew S. Poklepovic, Ignacio Duran, Saman Maleki Vareki, Arjun V. Balar, Jason J. Luke
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Renal involvement and metabolic alterations in adults patients affected by cystic fibrosis
Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange
01.12.2019 | Protocol | Ausgabe 1/2019
Open Access
A Phase I/II trial comparing autologous dendritic cell vaccine pulsed either with personalized peptides (PEP-DC) or with tumor lysate (OC-DC) in patients with advanced high-grade ovarian serous carcinoma
Apostolos Sarivalasis, Caroline Boudousquié, Klara Balint, Brian J. Stevenson, Philippe O. Gannon, Emanuela Marina Iancu, Laetitia Rossier, Silvia Martin Lluesma, Patrice Mathevet, Christine Sempoux, George Coukos, Urania Dafni, Alexandre Harari, Michal Bassani-Sternberg, Lana E. Kandalaft
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Molecular and computational analysis of 45 samples with a serologic weak D phenotype detected among 132,479 blood donors in northeast China
Xu Zhang, Guiji Li, Zhuren Zhou, Chaopeng Shao, Xuying Huang, Lichun Li, Xiaofeng Li, Ying Liu, Hua Fan, Jianping Li
01.12.2019 | Protocol | Ausgabe 1/2019
Open Access
Microbiota, type 2 diabetes and non-alcoholic fatty liver disease: protocol of an observational study
Benedetta M. Motta, Christoph Grander, Martin Gögele, Luisa Foco, Vladimir Vukovic, Roberto Melotti, Christian Fuchsberger, Alessandro De Grandi, Chiara Cantaloni, Anne Picard, Deborah Mascalzoni, Alessandra Rossini, Cristian Pattaro, Herbert Tilg, Peter P. Pramstaller
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Prognostic nomogram for bladder cancer with brain metastases: a National Cancer Database analysis
Zhixian Yao, Zhong Zheng, Wu Ke, Renjie Wang, Xingyu Mu, Feng Sun, Xiang Wang, Shivank Garg, Wenyin Shi, Yinyan He, Zhihong Liu
01.12.2019 | Research | Ausgabe 1/2019
Open Access
SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck
Sara I. Pai, Ezra E. W. Cohen, Derrick Lin, George Fountzilas, Edward S. Kim, Holger Mehlhorn, Neus Baste, Daniel Clayburgh, Loren Lipworth, Carlo Resteghini, Nawar Shara, Takashi Fujii, Jun Zhang, Michael Stokes, Huifen Wang, Philip Twumasi-Ankrah, Sophie Wildsmith, Asud Khaliq, Giovanni Melillo, Norah Shire
01.12.2019 | Research | Ausgabe 1/2019
Open Access
Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity
Ruochuan Zang, Xinfeng Wang, Runsen Jin, Yuanyuan Lei, Jianbing Huang, Chengming Liu, Sufei Zheng, Fang Zhou, Qian Wu, Nan Sun, Shugeng Gao, Jie He
