Ausgabe 1/2016
Inhalt (83 Artikel)
Effect of low doses of actinomycin D on neuroblastoma cell lines
Constanza L. Cortes, Sonia R. Veiga, Eugènia Almacellas, Javier Hernández-Losa, Joan C. Ferreres, Sara C. Kozma, Santiago Ambrosio, George Thomas, Albert Tauler
Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer
Paige Chandler, Bose S. Kochupurakkal, Samina Alam, Andrea L. Richardson, David I. Soybel, Shannon L. Kelleher
PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
Ninel Azoitei, Alexander Becher, Konrad Steinestel, Arefeh Rouhi, Kristina Diepold, Felicitas Genze, Thomas Simmet, Thomas Seufferlein
Piwi-interacting RNAs in cancer: emerging functions and clinical utility
Kevin W. Ng, Christine Anderson, Erin A. Marshall, Brenda C. Minatel, Katey S. S. Enfield, Heather L. Saprunoff, Wan L. Lam, Victor D. Martinez
Deregulated expression of cryptochrome genes in human colorectal cancer
Gianluigi Mazzoccoli, Tommaso Colangelo, Anna Panza, Rosa Rubino, Angelo De Cata, Cristiana Tiberio, Maria Rosa Valvano, Valerio Pazienza, Giuseppe Merla, Bartolomeo Augello, Domenico Trombetta, Clelia Tiziana Storlazzi, Gemma Macchia, Annamaria Gentile, Francesca Tavano, Manlio Vinciguerra, Giovanni Bisceglia, Valeria Rosato, Vittorio Colantuoni, Lina Sabatino, Ada Piepoli
Estrogen receptor α in cancer associated fibroblasts suppresses prostate cancer invasion via reducing CCL5, IL6 and macrophage infiltration in the tumor microenvironment
Chiuan-Ren Yeh, Spencer Slavin, Jun Da, Iawen Hsu, Jie Luo, Guang-Qian Xiao, Jie Ding, Fu-Ju Chou, Shuyuan Yeh
Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase/Akt pathway
Brendan C. Luey, Felicity E. B. May
miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis
Tingting Huang, Wei Kang, Bin Zhang, Feng Wu, Yujuan Dong, Joanna H. M. Tong, Weiqin Yang, Yuhang Zhou, Li Zhang, Alfred S. L. Cheng, Jun Yu, Ka Fai To
Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma
Sarah Schrödter, Martin Braun, Isabella Syring, Niklas Klümper, Mario Deng, Doris Schmidt, Sven Perner, Stefan C Müller, Jörg Ellinger
MicroRNA-505 functions as a tumor suppressor in endometrial cancer by targeting TGF-α
Shuo Chen, Kai-Xuan Sun, Bo-Liang Liu, Zhi-Hong Zong, Yang Zhao
Aurora kinase targeting in lung cancer reduces KRAS-induced transformation
Edmilson Ozorio dos Santos, Tatiana Correa Carneiro-Lobo, Mateus Nobrega Aoki, Elena Levantini, Daniela Sanchez Bassères
Does VEGF facilitate local tumor growth and spread into the abdominal cavity by suppressing endothelial cell adhesion, thus increasing vascular peritoneal permeability followed by ascites production in ovarian cancer?
Inga Bekes, Thomas W. P. Friedl, Tanja Köhler, Volker Möbus, Wolfgang Janni, Achim Wöckel, Christine Wulff
Erratum to: ‘Phosphoproteomic analysis reveals Smarcb1 dependent EGFR signaling in Malignant Rhabdoid tumor cells’
Jonatan Darr, Agnes Klochendler, Sara Isaac, Tamar Geiger, Amir Eden
Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia
Chien-Hung Yeh, Xue Tao Bai, Ramona Moles, Lee Ratner, Thomas A. Waldmann, Toshiki Watanabe, Christophe Nicot
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
Carmela Ciccarelli, Francesca Vulcano, Luisa Milazzo, Giovanni Luca Gravina, Francesco Marampon, Giampiero Macioce, Adele Giampaolo, Vincenzo Tombolini, Virginia Di Paolo, Hamisa Jane Hassan, Bianca Maria Zani
Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients
Jian Ruan, Haiyan Zheng, Xiaodong Rong, Xiaomin Rong, Junyi Zhang, Weijia Fang, Peng Zhao, Rongcheng Luo
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications
Silvia Juliana Serrano-Gomez, Mazvita Maziveyi, Suresh K. Alahari
Erratum to: ‘Expression of granzyme B sensitizes ALK+ ALCL tumour cells to apoptosis-inducing drugs’
Jodel D. Pearson, Jingxi Zhang, Zuoqiao Wu, Kayla D. Thew, Katelynn J. Rowe, Julinor T. C. Bacani, Robert J. Ingham
Erratum to: ‘Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia’
Chien-Hung Yeh, Xue Tao Bai, Ramona Moles, Lee Ratner, Thomas A. Waldmann, Toshiki Watanabe, Christophe Nicot
Erratum to: ‘Deregulation of the FOXM1 target gene network and its coregulatory partners in oesophageal adenocarcinoma’
Elizabeth F. Wiseman, Xi Chen, Namshik Han, Aaron Webber, Zongling Ji, Andrew D. Sharrocks, Yeng S. Ang
ERK mediated upregulation of death receptor 5 overcomes the lack of p53 functionality in the diaminothiazole DAT1 induced apoptosis in colon cancer models: efficiency of DAT1 in Ras-Raf mutated cells
Reshma Thamkachy, Rohith Kumar, K. N. Rajasekharan, Suparna Sengupta
Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway
Tianli Fan, Jing Chen, Lirong Zhang, Pan Gao, Yiran Hui, Peirong Xu, Xiaqing Zhang, Hongtao Liu
Hedgehog signaling: modulation of cancer properies and tumor mircroenvironment
Ann Hanna, Lalita A. Shevde
GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer
Xiumei Sheng, Nathan Bowen, Zhengxin Wang
ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models
Danielle L. Peacock Brooks, Luciana P. Schwab, Raisa Krutilina, Deanna N. Parke, Aarti Sethuraman, David Hoogewijs, Alexandra Schörg, Lauren Gotwald, Meiyun Fan, Roland H. Wenger, Tiffany N. Seagroves
Inhibition of BMP and of TGFβ receptors downregulates expression of XIAP and TAK1 leading to lung cancer cell death
Dave J. Augeri, Elaine Langenfeld, Monica Castle, John A. Gilleran, John Langenfeld
Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism
Mayakannan Manikandan, Arungiri Kuha Deva Magendhra Rao, Ganesan Arunkumar, Meenakshisundaram Manickavasagam, Kottayasamy Seenivasagam Rajkumar, Ramamurthy Rajaraman, Arasambattu Kannan Munirajan
A bioavailable cathepsin S nitrile inhibitor abrogates tumor development
Richard D. A. Wilkinson, Andrew Young, Roberta E. Burden, Rich Williams, Christopher J. Scott
Higher levels of TIMP-1 expression are associated with a poor prognosis in triple-negative breast cancer
Guangcun Cheng, Xuemei Fan, Mingang Hao, Jinglong Wang, Xiaoming Zhou, Xueqing Sun
Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma
Masanori Nojima, Takeshi Matsui, Akihiro Tamori, Shoji Kubo, Ken Shirabe, Koichi Kimura, Mitsuo Shimada, Tohru Utsunomiya, Yasuteru Kondo, Etsuko Iio, Yutaka Naito, Takahiro Ochiya, Yasuhito Tanaka
ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells
Hiroto Fukushima, Makiko Yasumoto, Sachiko Ogasawara, Jun Akiba, Yuhei Kitasato, Masamichi Nakayama, Yoshiki Naito, Yusuke Ishida, Yoshinobu Okabe, Masafumi Yasunaga, Hiroyuki Horiuchi, Etsuko Sakamoto, Hiraku Itadani, Shinji Mizuarai, Shinji Oie, Hirohisa Yano
Detection of cancer cells using SapC-DOPS nanovesicles
Harold W. Davis, Nida Hussain, Xiaoyang Qi
Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells
Prson Gautam, Leena Karhinen, Agnieszka Szwajda, Sawan Kumar Jha, Bhagwan Yadav, Tero Aittokallio, Krister Wennerberg
Erratum to: ‘Hedgehog signaling: modulation of cancer properties and tumor microenvironment’
Ann Hanna, Lalita A. Shevde
Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
Yun Su, Maria A. Guarnera, HongBin Fang, Feng Jiang
Clinical significance of microRNAs in chronic and acute human leukemia
Chien-Hung Yeh, Ramona Moles, Christophe Nicot
Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib
Aline Houessinon, Catherine François, Chloé Sauzay, Christophe Louandre, Gaelle Mongelard, Corinne Godin, Sandra Bodeau, Shinichiro Takahashi, Zuzana Saidak, Laurent Gutierrez, Jean-Marc Régimbeau, Nathalie Barget, Jean-Claude Barbare, Nathalie Ganne, Bruno Chauffert, Romain Coriat, Antoine Galmiche
Circulating long non-coding RNAs in cancer: current status and future perspectives
Peng Qi, Xiao-yan Zhou, Xiang Du
Reciprocal activation between STAT3 and miR-181b regulates the proliferation of esophageal cancer stem-like cells via the CYLD pathway
Dan-dan Xu, Peng-jun Zhou, Ying Wang, Li Zhang, Wu-yu Fu, Bi-bo Ruan, Hai-peng Xu, Chao-zhi Hu, Lu Tian, Jin-hong Qin, Sheng Wang, Xiao Wang, Yi-cheng Li, Qiu-ying Liu, Zhe Ren, Rong Zhang, Yi-fei Wang
Diagnostic, prognostic and predictive value of cell-free miRNAs in prostate cancer: a systematic review
Edgars Endzeliņš, Vita Melne, Zane Kalniņa, Vilnis Lietuvietis, Una Riekstiņa, Alicia Llorente, Aija Linē
Essential role of miRNAs in orchestrating the biology of the tumor microenvironment
Jamie N. Frediani, Muller Fabbri
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Nenad Bartonicek, Jesper L. V. Maag, Marcel E. Dinger
KCa1.1, a calcium-activated potassium channel subunit alpha 1, is targeted by miR-17-5p and modulates cell migration in malignant pleural mesothelioma
Yuen Yee Cheng, Casey M. Wright, Michaela B. Kirschner, Marissa Williams, Kadir H. Sarun, Vladimir Sytnyk, Iryna Leshchynska, J. James Edelman, Michael P. Vallely, Brian C. McCaughan, Sonja Klebe, Nico van Zandwijk, Ruby C. Y. Lin, Glen Reid
Roles of acid-extruding ion transporters in regulation of breast cancer cell growth in a 3-dimensional microenvironment
Anne Poder Andersen, Mette Flinck, Eva Kjer Oernbo, Nis Borbye Pedersen, Birgitte Martine Viuff, Stine Falsig Pedersen
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model
Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang
Rad51C-ATXN7 fusion gene expression in colorectal tumors
Arjun Kalvala, Li Gao, Brittany Aguila, Kathleen Dotts, Mohammad Rahman, Serge P. Nana-Sinkam, Xiaoping Zhou, Qi-En Wang, Joseph Amann, Gregory A. Otterson, Miguel A. Villalona-Calero, Wenrui Duan
Clinical relevance of circulating cell-free microRNAs in ovarian cancer
Koji Nakamura, Kenjiro Sawada, Akihiko Yoshimura, Yasuto Kinose, Erika Nakatsuka, Tadashi Kimura
Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition
Yumi Miyazaki, Shyuichirou Matsubara, Qiang Ding, Koichiro Tsukasa, Makoto Yoshimitsu, Ken-ichiro Kosai, Sonshin Takao
Long noncoding RNAs as novel predictors of survival in human cancer: a systematic review and meta-analysis
Stylianos Serghiou, Aikaterini Kyriakopoulou, John P. A. Ioannidis
RETRACTED ARTICLE: MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial–mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma
Zhenyue He, Jun Yi, Xiaolong Liu, Jing Chen, Siqi Han, Li Jin, Longbang Chen, Haizhu Song
ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis
Mei Xu, Zhenhua Ren, Xin Wang, Ashley Comer, Jacqueline A. Frank, Zun-ji Ke, Yi Huang, Zhuo Zhang, Xianglin Shi, Siying Wang, Jia Luo
MiR-204 silencing in intraepithelial to invasive cutaneous squamous cell carcinoma progression
Agustí Toll, Rocío Salgado, Blanca Espinet, Angel Díaz-Lagares, Eugenia Hernández-Ruiz, Evelyn Andrades, Juan Sandoval, Manel Esteller, Ramón M Pujol, Inmaculada Hernández-Muñoz
Proteinase-activated receptor 2 (PAR2) in hepatic stellate cells – evidence for a role in hepatocellular carcinoma growth in vivo
Franziska Mußbach, Hendrik Ungefroren, Bernd Günther, Kathrin Katenkamp, Petra Henklein, Martin Westermann, Utz Settmacher, Lennart Lenk, Susanne Sebens, Jörg P. Müller, Frank-Dietmar Böhmer, Roland Kaufmann
Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer
Yaqi Li, Lei Liang, Weixing Dai, Guoxiang Cai, Ye Xu, Xinxiang Li, Qingguo Li, Sanjun Cai
Wnt-signalling pathways and microRNAs network in carcinogenesis: experimental and bioinformatics approaches
Emenike K. Onyido, Eloise Sweeney, Abdolrahman Shams Nateri
RETRACTED ARTICLE: HOXA7 plays a critical role in metastasis of liver cancer associated with activation of Snail
Bo Tang, Guangying Qi, Xiaoyu Sun, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Xinjin Guo, Songqing He
CCL18 from ascites promotes ovarian cancer cell migration through proline-rich tyrosine kinase 2 signaling
Denis Lane, Isabelle Matte, Claude Laplante, Perrine Garde-Granger, Alex Carignan, Paul Bessette, Claudine Rancourt, Alain Piché
Rac1-mediated cytoskeleton rearrangements induced by intersectin-1s deficiency promotes lung cancer cell proliferation, migration and metastasis
Niranjan Jeganathan, Dan Predescu, Jin Zhang, Fei Sha, Cristina Bardita, Monal Patel, Stephen Wood, Jeffrey A. Borgia, Robert A. Balk, Sanda Predescu
A long non-coding RNA signature to improve prognosis prediction of gastric cancer
Xiaoqiang Zhu, Xianglong Tian, Chenyang Yu, Chaoqin Shen, Tingting Yan, Jie Hong, Zheng Wang, Jing-Yuan Fang, Haoyan Chen
Synthetic lethality in lung cancer and translation to clinical therapies
Ada W. Y. Leung, Tanya de Silva, Marcel B. Bally, William W. Lockwood
Long non-coding RNAs: potential new biomarkers for predicting tumor invasion and metastasis
Chunyang Jiang, Xin Li, Hui Zhao, Huibin Liu
Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing
Valentina Kovaleva, Anna-Lena Geissler, Lisa Lutz, Ralph Fritsch, Frank Makowiec, Sebastian Wiesemann, Ulrich T. Hopt, Bernward Passlick, Martin Werner, Silke Lassmann
Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
Rashi Arora, Sharad Sawney, Vikas Saini, Chris Steffi, Manisha Tiwari, Daman Saluja
Less is more: low expression of MT1-MMP is optimal to promote migration and tumourigenesis of breast cancer cells
Mario A. Cepeda, Jacob J. H. Pelling, Caitlin L. Evered, Karla C. Williams, Zoey Freedman, Ioana Stan, Jessica A. Willson, Hon S. Leong, Sashko Damjanovski
Prediction of chemo-response in serous ovarian cancer
Jesus Gonzalez Bosquet, Andreea M. Newtson, Rebecca K. Chung, Kristina W. Thiel, Timothy Ginader, Michael J. Goodheart, Kimberly K. Leslie, Brian J. Smith
Emerging roles of T helper 17 and regulatory T cells in lung cancer progression and metastasis
Erin A. Marshall, Kevin W. Ng, Sonia H. Y. Kung, Emma M. Conway, Victor D. Martinez, Elizabeth C. Halvorsen, David A. Rowbotham, Emily A. Vucic, Adam W. Plumb, Daiana D. Becker-Santos, Katey S. S. Enfield, Jennifer Y. Kennett, Kevin L. Bennewith, William W. Lockwood, Stephen Lam, John C. English, Ninan Abraham, Wan L. Lam
Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis
M. Katie Conley-LaComb, Louie Semaan, Rajareddy Singareddy, Yanfeng Li, Elisabeth I. Heath, Seongho Kim, Michael L. Cher, Sreenivasa R. Chinni
Cancer stem cell metabolism: a potential target for cancer therapy
Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme, Arun Dharmarajan
miR-375 induces docetaxel resistance in prostate cancer by targeting SEC23A and YAP1
Yuan Wang, Rachel Lieberman, Jing Pan, Qi Zhang, Meijun Du, Peng Zhang, Marja Nevalainen, Manish Kohli, Niraj K. Shenoy, Hui Meng, Ming You, Liang Wang
Caveolin-1 in the regulation of cell metabolism: a cancer perspective
Zeribe Chike Nwosu, Matthias Philip Ebert, Steven Dooley, Christoph Meyer
Systems analysis identifies miR-29b regulation of invasiveness in melanoma
Miles C. Andrews, Joseph Cursons, Daniel G. Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren, Edmund J. Crampin
Comprehensive screening of target molecules by next-generation sequencing in patients with malignant solid tumors: guiding entry into phase I clinical trials
Yuko Tanabe, Hitoshi Ichikawa, Takashi Kohno, Hiroshi Yoshida, Takashi Kubo, Mamoru Kato, Satoru Iwasa, Atsushi Ochiai, Noboru Yamamoto, Yasuhiro Fujiwara, Kenji Tamura
PI3 kinase pathway regulated miRNome in glioblastoma: identification of miR-326 as a tumour suppressor miRNA
Zahid Nawaz, Vikas Patil, Yashna Paul, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram
Tryptophan hydroxylase 1 and 5-HT7 receptor preferentially expressed in triple-negative breast cancer promote cancer progression through autocrine serotonin signaling
Jaya Gautam, Suhrid Banskota, Sushil Chandra Regmi, Subi Ahn, Yong Hyun Jeon, Hyunyoung Jeong, Seung Joo Kim, Tae-gyu Nam, Byeong-Seon Jeong, Jung-Ae Kim
Cancer somatic mutations cluster in a subset of regulatory sites predicted from the ENCODE data
Nisar A. Shar, M. S. Vijayabaskar, David R. Westhead
Lipocalin2 suppresses metastasis of colorectal cancer by attenuating NF-κB-dependent activation of snail and epithelial mesenchymal transition
Meibao Feng, Jieqiong Feng, Wuzhen Chen, Wubin Wang, Xuesong Wu, Jing Zhang, Fangying Xu, Maode Lai
Acidic tumor microenvironment abrogates the efficacy of mTORC1 inhibitors
Seraina Faes, Adrian P. Duval, Anne Planche, Emilie Uldry, Tania Santoro, Catherine Pythoud, Jean-Christophe Stehle, Janine Horlbeck, Igor Letovanec, Nicolo Riggi, Nicolas Demartines, Olivier Dormond
STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer
Yuan-Ming Pan, Cheng-Gang Wang, Min Zhu, Rui Xing, Jian-Tao Cui, Wen-Mei Li, De-Dong Yu, Shu-Bin Wang, Wei Zhu, Ying-Jiang Ye, Yun Wu, Shan Wang, You-Yong Lu
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Tingting Huang, Yuhang Zhou, Alfred S. L. Cheng, Jun Yu, Ka Fai To, Wei Kang
Depletion of SAG/RBX2 E3 ubiquitin ligase suppresses prostate tumorigenesis via inactivation of the PI3K/AKT/mTOR axis
Mingjia Tan, Jie Xu, Javed Siddiqui, Felix Feng, Yi Sun
miR-138-5p contributes to cell proliferation and invasion by targeting Survivin in bladder cancer cells
Rong Yang, Minghui Liu, Hongwei Liang, Suhan Guo, Xu Guo, Min Yuan, Huibo Lian, Xiang Yan, Shiwei Zhang, Xi Chen, Feng Fang, Hongqian Guo, Chenyu Zhang
Choosing the right cell line for renal cell cancer research
Klaudia K. Brodaczewska, Cezary Szczylik, Michal Fiedorowicz, Camillo Porta, Anna M. Czarnecka