Ausgabe 1/2012
Inhalt (61 Artikel)
Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice
Jin Chu, Phillip F Giannopoulos, Carolina Ceballos-Diaz, Todd E Golde, Domenico Pratico
Wld S but not Nmnat1 protects dopaminergic neurites from MPP+neurotoxicity
Jo Ann V Antenor-Dorsey, Karen L O'Malley
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway
Youren Tong, Emilie Giaime, Hiroo Yamaguchi, Takaharu Ichimura, Yumin Liu, Huiqing Si, Huaibin Cai, Joseph V Bonventre, Jie Shen
Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
Karolien Bettens, Nathalie Brouwers, Sebastiaan Engelborghs, Jean-Charles Lambert, Ekaterina Rogaeva, Rik Vandenberghe, Nathalie Le Bastard, Florence Pasquier, Steven Vermeulen, Jasper Van Dongen, Maria Mattheijssens, Karin Peeters, Richard Mayeux, Peter St George-Hyslop, Philippe Amouyel, Peter P De Deyn, Kristel Sleegers, Christine Van Broeckhoven
Rapid glutamate receptor 2 trafficking during retinal degeneration
Yanhua Lin, Bryan W Jones, Aihua Liu, Félix R Vazquéz-Chona, J Scott Lauritzen, W Drew Ferrell, Robert E Marc
Spinal cord trauma and the molecular point of no return
Ping K Yip, Andrea Malaspina
Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS
Ruohan Xia, Yajuan Liu, Liuqing Yang, Jozsef Gal, Haining Zhu, Jianhang Jia
Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease
Miriam A Hickey, Chunni Zhu, Vera Medvedeva, Renata P Lerner, Stefano Patassini, Nicholas R Franich, Panchanan Maiti, Sally A Frautschy, Scott Zeitlin, Michael S Levine, Marie-Françoise Chesselet
Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody
Katherine L Youmans, Leon M Tai, Takahisa Kanekiyo, W Blaine Stine Jr, Sara-Claude Michon, Evelyn Nwabuisi-Heath, Arlene M Manelli, Yifan Fu, Sean Riordan, William A Eimer, Lester Binder, Guojun Bu, Chunjiang Yu, Dean M Hartley, Mary Jo LaDu
Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPreslevel disparity
Victoria Lewis, Cathryn L Haigh, Colin L Masters, Andrew F Hill, Victoria A Lawson, Steven J Collins
Nurr1 regulates Top IIβ and functions in axon genesis of mesencephalic dopaminergic neurons
Xin Heng, Gang Jin, Xin Zhang, Dehuang Yang, Mingzhe Zhu, Shijun Fu, Xuping Li, Weidong Le
FE65 as a link between VLDLR and APP to regulate their trafficking and processing
Sonya B Dumanis, Kelly A Chamberlain, Yoo Jin Sohn, Young Jin Lee, Suzanne Y Guénette, Toshiharu Suzuki, Paul M Mathews, Daniel TS Pak, G William Rebeck, Yoo-hun Suh, Hee-Sae Park, Hyang-Sook Hoe
Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease
Carolina Cabeza, Alicia Figueroa, Oscar M Lazo, Carolina Galleguillos, Claudia Pissani, Andrés Klein, Christian Gonzalez-Billault, Nibaldo C Inestrosa, Alejandra R Alvarez, Silvana Zanlungo, Francisca C Bronfman
Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
Mariet Allen, Fanggeng Zou, High Seng Chai, Curtis S Younkin, Richard Miles, Asha A Nair, Julia E Crook, V Shane Pankratz, Minerva M Carrasquillo, Christopher N Rowley, Thuy Nguyen, Li Ma, Kimberly G Malphrus, Gina Bisceglio, Alexandra I Ortolaza, Ryan Palusak, Sumit Middha, Sooraj Maharjan, Constantin Georgescu, Debra Schultz, Fariborz Rakhshan, Christopher P Kolbert, Jin Jen, Sigrid B Sando, Jan O Aasly, Maria Barcikowska, Ryan J Uitti, Zbigniew K Wszolek, Owen A Ross, Ronald C Petersen, Neill R Graff-Radford, Dennis W Dickson, Steven G Younkin, Nilüfer Ertekin-Taner
Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+ in cognitively intact aged individuals with Alzheimer’s disease neuropathology
Nicole L Bjorklund, Lindsay C Reese, V-M Sadagoparamanujam, Valeria Ghirardi, Randall L Woltjer, Giulio Taglialatela
Measurement of apolipoprotein E and amyloid β clearance rates in the mouse brain using bolus stable isotope labeling
Jacob M Basak, Jungsu Kim, Yuriy Pyatkivskyy, Kristin R Wildsmith, Hong Jiang, Maia Parsadanian, Bruce W Patterson, Randall J Bateman, David M Holtzman
Regulation of mitochondrial permeability transition pore by PINK1
Clement A Gautier, Emilie Giaime, Erica Caballero, Lucía Núñez, Zhiyin Song, David Chan, Carlos Villalobos, Jie Shen
Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia
Robert Tamayev, Luciano D’Adamio
Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
Cheng Fang, Dennis Bourdette, Gary Banker
Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects
Saori Hata, Miyako Taniguchi, Yi Piao, Takeshi Ikeuchi, Anne M Fagan, David M Holtzman, Randall Bateman, Hamid R Sohrabi, Ralph N Martins, Sam Gandy, Katsuya Urakami, Toshiharu Suzuki
A molecular signature in blood identifies early Parkinson’s disease
Leonid Molochnikov, Jose M Rabey, Evgenya Dobronevsky, Ubaldo Bonuccelli, Roberto Ceravolo, Daniela Frosini, Edna Grünblatt, Peter Riederer, Christian Jacob, Judith Aharon-Peretz, Yulia Bashenko, Moussa BH Youdim, Silvia A Mandel
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
Yonghao Zhao, Yunshu Wang, Jiaye Yang, Xin Wang, Yingjun Zhao, Xian Zhang, Yun-wu Zhang
LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors
Kelly M Hinkle, Mei Yue, Bahareh Behrouz, Justus C Dächsel, Sarah J Lincoln, Erin E Bowles, Joel E Beevers, Brittany Dugger, Beate Winner, Iryna Prots, Caroline B Kent, Kenya Nishioka, Wen-Lang Lin, Dennis W Dickson, Christopher J Janus, Matthew J Farrer, Heather L Melrose
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Paramita Chakrabarty, Li Tianbai, Amanda Herring, Carolina Ceballos-Diaz, Pritam Das, Todd E Golde
Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
Carole J Proctor, Ilse Sanet Pienaar, Joanna L Elson, Thomas BL Kirkwood
LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease
Julie Brodeur, Caroline Thériault, Mélissa Lessard-Beaudoin, Alexandre Marcil, Sophie Dahan, Christine Lavoie
Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult
Shaefali P Rodgers, Heather A Born, Pritam Das, Joanna L Jankowsky
Apoptosis-inducing factor downregulation increased neuronal progenitor, but not stem cell, survival in the neonatal hippocampus after cerebral hypoxia-ischemia
Yanyan Sun, Yu Zhang, Xiaoyang Wang, Klas Blomgren, Changlian Zhu
Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
Zhao-Hui Xu, Qi Yang, Bin Feng, Shui-bing Liu, Nan Zhang, Jiang-hao Xing, Xiao-Qiang Li, Yu-mei Wu, Guo-Dong Gao, Ming-Gao Zhao
Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease
Keizo Sugaya, Shiro Matsubara
The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities
Tatsunori Maekawa, Sayuri Mori, Yui Sasaki, Takashi Miyajima, Sadahiro Azuma, Etsuro Ohta, Fumiya Obata
Mass spectrometry quantification of clusterin in the human brain
Junjun Chen, Meiyao Wang, Illarion V Turko
Identification of BACE2 as an avid ß-amyloid-degrading protease
Samer O Abdul-Hay, Tomoko Sahara, Melinda McBride, Dongcheul Kang, Malcolm A Leissring
Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level
Georg Nübling, Benedikt Bader, Johannes Levin, Jenna Hildebrandt, Hans Kretzschmar, Armin Giese
Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons
Terina N Martinez, Xi Chen, Sibali Bandyopadhyay, Alfred H Merrill, Malú G Tansey
IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
Hong Lian, David J Shim, Samson SK Gaddam, Jennifer Rodriguez-Rivera, Brittany R Bitner, Robia G Pautler, Claudia S Robertson, Hui Zheng
Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice
Suhail Rasool, Ricardo Albay III, Hilda Martinez-Coria, Leonid Breydo, Jessica Wu, Saskia Milton, Sunit Misra, Andy Tran, Anna Pensalfini, Frank Laferla, Rakez Kayed, Charles G Glabe
Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology
Pritam Das, Christophe Verbeeck, Lisa Minter, Paramita Chakrabarty, Kevin Felsenstein, Thomas Kukar, Ghulam Maharvi, Abdul Fauq, Barbara A Osborne, Todd E Golde
Suppression of dynamin GTPase decreases α-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy
Masatoshi Konno, Takafumi Hasegawa, Toru Baba, Emiko Miura, Naoto Sugeno, Akio Kikuchi, Fabienne C Fiesel, Tsutomu Sasaki, Masashi Aoki, Yasuto Itoyama, Atsushi Takeda
L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL
Haigang Ren, Kai Fu, Chenchen Mu, Xuechu Zhen, Guanghui Wang
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M Danzer, Lisa R Kranich, Wolfgang P Ruf, Ozge Cagsal-Getkin, Ashley R Winslow, Liya Zhu, Charles R Vanderburg, Pamela J McLean
Inhibition of MMP-9 by a selective gelatinase inhibitor protects neurovasculature from embolic focal cerebral ischemia
Jiankun Cui, Shanyan Chen, Chunyang Zhang, Fanjun Meng, Wei Wu, Rong Hu, Or Hadass, Tareq Lehmidi, Gregory J Blair, Mijoon Lee, Mayland Chang, Shahriar Mobashery, Grace Y Sun, Zezong Gu
ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT
Peter O Bauer, Roman Hudec, Anand Goswami, Masaru Kurosawa, Gen Matsumoto, Katsuhiko Mikoshiba, Nobuyuki Nukina
Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson’s disease
Paula Desplats, Pruthul Patel, Kori Kosberg, Michael Mante, Christina Patrick, Edward Rockenstein, Masayo Fujita, Makoto Hashimoto, Eliezer Masliah
Endogenous TDP-43, but not FUS, contributes to stress granule assembly via G3BP
Anaïs Aulas, Stéphanie Stabile, Christine Vande Velde
Bone marrow-derived fibroblast growth factor-2 induces glial cell proliferation in the regenerating peripheral nervous system
Victor Tulio Ribeiro-Resende, Alvaro Carrier-Ruiz, Robertha M R Lemes, Ricardo A M Reis, Rosalia Mendez-Otero
Neuromuscular effects of G93A-SOD1 expression in zebrafish
Stacey A Sakowski, J Simon Lunn, Angela S Busta, Sang Su Oh, Grettel Zamora-Berridi, Madeline Palmer, Andrew A Rosenberg, Stephen G Philip, James J Dowling, Eva L Feldman
BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer’s disease
Linda Chami, Frédéric Checler
Progranulin regulates neuronal outgrowth independent of Sortilin
Jennifer Gass, Wing C Lee, Casey Cook, Nicole Finch, Caroline Stetler, Karen Jansen-West, Jada Lewis, Christopher D Link, Rosa Rademakers, Anders Nykjær, Leonard Petrucelli
Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
Christophe Verbeeck, Qiudong Deng, Mariely DeJesus-Hernandez, Georgia Taylor, Carolina Ceballos-Diaz, Jannet Kocerha, Todd Golde, Pritam Das, Rosa Rademakers, Dennis W Dickson, Thomas Kukar
Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE) - and amyloid beta 1-42-induced signal transduction in glial cells
Alexander Slowik, Julika Merres, Anne Elfgen, Sandra Jansen, Fabian Mohr, Christoph J Wruck, Thomas Pufe, Lars-Ove Brandenburg
Regulated protein aggregation: stress granules and neurodegeneration
Benjamin Wolozin
Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer’s disease
Yuhki Saito, Tsuyoshi Inoue, Gang Zhu, Naoki Kimura, Motohiro Okada, Masaki Nishimura, Nobuyuki Kimura, Shigeo Murayama, Sunao Kaneko, Ryuichi Shigemoto, Keiji Imoto, Toshiharu Suzuki
Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegansfor drug screening for Alzheimer’s disease
Gawain McColl, Blaine R Roberts, Tara L Pukala, Vijaya B Kenche, Christine M Roberts, Christopher D Link, Timothy M Ryan, Colin L Masters, Kevin J Barnham, Ashley I Bush, Robert A Cherny
Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection
Robert Tamayev, Nsikan Akpan, Ottavio Arancio, Carol M Troy, Luciano D’Adamio
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
Keiichi Inoue, Joanne Rispoli, Hanoch Kaphzan, Eric Klann, Emily I Chen, Jongpil Kim, Masaaki Komatsu, Asa Abeliovich
Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
Carolina Franco, Silvia Fernández, Ignacio Torres-Alemán
The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease
Hannah Brautigam, John W Steele, David Westaway, Paul E Fraser, Peter H St George-Hyslop, Sam Gandy, Patrick R Hof, Dara L Dickstein
Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
Kathryn Rogers, Kevin M Felsenstein, Lori Hrdlicka, Zhiming Tu, Faris Albayya, Winnie Lee, Sarah Hopp, Mary-Jo Miller, Darcie Spaulding, Zhiyong Yang, Hilliary Hodgdon, Scott Nolan, Melody Wen, Don Costa, Jean-Francois Blain, Emily Freeman, Bart De Strooper, Veerle Vulsteke, Louise Scrocchi, Henrik Zetterberg, Erik Portelius, Birgit Hutter-Paier, Daniel Havas, Michael Ahlijanian, Dorothy Flood, Liza Leventhal, Gideon Shapiro, Holger Patzke, Richard Chesworth, Gerhard Koenig
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Manuel Torres, Sebastian Jimenez, Raquel Sanchez-Varo, Victoria Navarro, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Irene Carmona, Jose Carlos Davila, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica