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Erschienen in: DNP - Der Neurologe & Psychiater 9-10/2017

03.10.2017 | Demenz | Zertifizierte Fortbildung

Patienten mit Demenz

Medikamentöse Alternativen zu Antipsychotika bei Verhaltensstörungen

verfasst von: Dr. med. Johannes Rosenboom

Erschienen in: DNP – Die Neurologie & Psychiatrie | Ausgabe 9-10/2017

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Zusammenfassung

Noch immer werden viele demente Patienten mit störenden Verhaltensweisen überwiegend mit Neuroleptika behandelt. Die Behandlung von älteren Patienten mit Neuroleptika ist jedoch mit erheblichen Nebenwirkungen und Risiken verbunden. Alternative pharmakologische Behandlungsmöglichkeiten sind verfügbar und oft besser verträglich. Nach einigen grundsätzlichen Überlegungen werden diese im Folgenden mit ihren möglichen Indikationsbereichen und spezifischen Besonderheiten dargestellt.
Literatur
1.
2.
Zurück zum Zitat Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Neurologie(DGPPN), S 3 Leitlinie Demenz, August 2015 Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Neurologie(DGPPN), S 3 Leitlinie Demenz, August 2015
3.
Zurück zum Zitat Pijnenburg YA, Sampson PL, Harvey RJ, Fox NC, et al. Vulnerability to neuroleptic side effects in frontotemporal lobar degeneration. Int J Geriatr Psychiatry 2003;18:67–72CrossRefPubMed Pijnenburg YA, Sampson PL, Harvey RJ, Fox NC, et al. Vulnerability to neuroleptic side effects in frontotemporal lobar degeneration. Int J Geriatr Psychiatry 2003;18:67–72CrossRefPubMed
4.
Zurück zum Zitat Deutsche Gesellschaft für Allgemeinmedizin (DEGAM)DEGAM Leitlinie Nr. 12 Deutsche Gesellschaft für Allgemeinmedizin (DEGAM)DEGAM Leitlinie Nr. 12
5.
Zurück zum Zitat Haupt M, Jänner M, Ebeling S, Stierstorfer A, Kretschmar C. Presentation and stability of noncognitive symptom patterns in patients with Alzheimer’s disease. Alz Dis Ass Dis. 1998; 12 323–329CrossRef Haupt M, Jänner M, Ebeling S, Stierstorfer A, Kretschmar C. Presentation and stability of noncognitive symptom patterns in patients with Alzheimer’s disease. Alz Dis Ass Dis. 1998; 12 323–329CrossRef
6.
Zurück zum Zitat Drach L M, Adler G, Medikamentöse Alternativen zu Antipsychotika bei Demenzkranken mit Verhaltensstörungen, Psychopharmakotherapie 2010;17:264–73 Drach L M, Adler G, Medikamentöse Alternativen zu Antipsychotika bei Demenzkranken mit Verhaltensstörungen, Psychopharmakotherapie 2010;17:264–73
7.
Zurück zum Zitat Mckeith I, Del Ser T, Spano P, et al.: Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 2000; 356: 2031–2036CrossRefPubMed Mckeith I, Del Ser T, Spano P, et al.: Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 2000; 356: 2031–2036CrossRefPubMed
8.
Zurück zum Zitat Emre M, Aarsland D, Albanese A, et al.: Rivastigmine for dementia associated with Parkinsons desease. N Engl J Med 2004;351: 2509–2518CrossRefPubMed Emre M, Aarsland D, Albanese A, et al.: Rivastigmine for dementia associated with Parkinsons desease. N Engl J Med 2004;351: 2509–2518CrossRefPubMed
9.
Zurück zum Zitat Birks J: Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006(1):CD005593. Birks J, Harvey RJ: Donepezil for dementia due to Alzheimer’s disease. Cochrane Database Syst Rev 2006(1): CD001190. Birks J: Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst Rev. 2006(1):CD005593. Birks J, Harvey RJ: Donepezil for dementia due to Alzheimer’s disease. Cochrane Database Syst Rev 2006(1): CD001190.
10.
Zurück zum Zitat Loy C, Schneider L: Galantamine for Alzheimers disease and mild kognitive impairment. Cochrane Database Syst Rev 2006 (1): CD001747 Loy C, Schneider L: Galantamine for Alzheimers disease and mild kognitive impairment. Cochrane Database Syst Rev 2006 (1): CD001747
11.
Zurück zum Zitat Cummings JL, Mackell J, Kaufer D: Behavioral effects of current Alzheimer’s disease treatments: adescriptive review. Alzheimers Dement 2008; 4: 49–60.CrossRefPubMed Cummings JL, Mackell J, Kaufer D: Behavioral effects of current Alzheimer’s disease treatments: adescriptive review. Alzheimers Dement 2008; 4: 49–60.CrossRefPubMed
12.
Zurück zum Zitat Mc Shane R, Areosa Sastre A, Minakaran N: Memantine for dementia. Cochrane Database Syst Rev 2006(2): CD003154 Mc Shane R, Areosa Sastre A, Minakaran N: Memantine for dementia. Cochrane Database Syst Rev 2006(2): CD003154
13.
Zurück zum Zitat Howard R, McShane R, Lindesay J, et al.: Donepezil and Memantine for moderate-to- severe Alzheimer’s disease. N Engl J Med 2012; 366: 893–903.CrossRefPubMed Howard R, McShane R, Lindesay J, et al.: Donepezil and Memantine for moderate-to- severe Alzheimer’s disease. N Engl J Med 2012; 366: 893–903.CrossRefPubMed
14.
Zurück zum Zitat Wilcock GK, Ballard CG, Cooper JA, et al.: Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer disease. A pooled analysis of 3 studies. J Clin. Psychiatry2008; 69:341–348CrossRefPubMed Wilcock GK, Ballard CG, Cooper JA, et al.: Memantine for agitation/aggression and psychosis in moderately severe to severe Alzheimer disease. A pooled analysis of 3 studies. J Clin. Psychiatry2008; 69:341–348CrossRefPubMed
15.
Zurück zum Zitat Boxer AL, Lipton Am, Womack K, Merilees J, et al. An open-label study of memantine treatment in 3 subtyps of frontotemporal lobar degeneration. Alzheimer Dis Assoc Disord 2009;23:211–17CrossRefPubMedPubMedCentral Boxer AL, Lipton Am, Womack K, Merilees J, et al. An open-label study of memantine treatment in 3 subtyps of frontotemporal lobar degeneration. Alzheimer Dis Assoc Disord 2009;23:211–17CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Flicker L, Grimley Evans G. Pirazetam for dementia and cognitive impairment. Cochrane Database Syst. Rev 2001; CD001011. Flicker L, Grimley Evans G. Pirazetam for dementia and cognitive impairment. Cochrane Database Syst. Rev 2001; CD001011.
17.
Zurück zum Zitat Pollock BG, Mulsant BH, Rosen J, et al.: Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. Am J Psychiatry 2002; 159: 460–465.288.CrossRefPubMed Pollock BG, Mulsant BH, Rosen J, et al.: Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. Am J Psychiatry 2002; 159: 460–465.288.CrossRefPubMed
18.
Zurück zum Zitat Porsteinsson AP, Drye LT, Pollock BG, et al.: Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 2014; 311: 682–691.CrossRefPubMedPubMedCentral Porsteinsson AP, Drye LT, Pollock BG, et al.: Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA 2014; 311: 682–691.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Lyketsos CG, DelCampo L, Steinberg M, et al.: Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry 2003; 60: 737–746.CrossRefPubMed Lyketsos CG, DelCampo L, Steinberg M, et al.: Treating depression in Alzheimer disease: efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Arch Gen Psychiatry 2003; 60: 737–746.CrossRefPubMed
20.
Zurück zum Zitat Thompson S, Herrmann N, Rapoport MJ, et al.: Efficacy and safety of antidepressants for treatment of depression in Alzheimer’s disease: a metaanalysis. Can J Psychiatry 2007; 52: 248–255.CrossRefPubMed Thompson S, Herrmann N, Rapoport MJ, et al.: Efficacy and safety of antidepressants for treatment of depression in Alzheimer’s disease: a metaanalysis. Can J Psychiatry 2007; 52: 248–255.CrossRefPubMed
21.
Zurück zum Zitat Roth M, Mountjoy CQ, Amrein R: Moclobemide in elderly patients with cognitive decline and depression:an international double-blind, placebo-controlled trial. Br J Psychiatry 1996; 168: 149–157.CrossRefPubMed Roth M, Mountjoy CQ, Amrein R: Moclobemide in elderly patients with cognitive decline and depression:an international double-blind, placebo-controlled trial. Br J Psychiatry 1996; 168: 149–157.CrossRefPubMed
22.
Zurück zum Zitat Moretti R, Torre P, Antonello RM, Cazzato G, et al. Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-monst study. Eur Neurol 2003;49:13–9.CrossRefPubMed Moretti R, Torre P, Antonello RM, Cazzato G, et al. Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-monst study. Eur Neurol 2003;49:13–9.CrossRefPubMed
23.
Zurück zum Zitat Swartz RJ, Miller BL, Lesser IM, Darby AL. Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors. J. Clin Psychiatry 1997;58:212–6CrossRefPubMed Swartz RJ, Miller BL, Lesser IM, Darby AL. Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors. J. Clin Psychiatry 1997;58:212–6CrossRefPubMed
24.
Zurück zum Zitat Lebert F, Stekke W, Hasenbroekx C, et al.: Frontotemporal dementia: a randomized controlled trial with trazodon. Dement Geratr Cogn Disord 2004;17:355–9CrossRef Lebert F, Stekke W, Hasenbroekx C, et al.: Frontotemporal dementia: a randomized controlled trial with trazodon. Dement Geratr Cogn Disord 2004;17:355–9CrossRef
25.
Zurück zum Zitat Deakin JB, Rahman S, Nestor PJ, et al.: Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology (Berl) 2004;172: 400–408.CrossRef Deakin JB, Rahman S, Nestor PJ, et al.: Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology (Berl) 2004;172: 400–408.CrossRef
26.
Zurück zum Zitat Benkert, Hippius, Kompendium der psychiatrischen Pharmakotherapie, 9. Auflage, 2013, Springer Verlag Benkert, Hippius, Kompendium der psychiatrischen Pharmakotherapie, 9. Auflage, 2013, Springer Verlag
27.
Zurück zum Zitat Roth M, Mountjoy CR, Amrein R. Moclobemide in elderly patients with cognitive decline and depression: an international double blind, placebo controlled trial. Br J Psychiatry 1996;168:149–57CrossRefPubMed Roth M, Mountjoy CR, Amrein R. Moclobemide in elderly patients with cognitive decline and depression: an international double blind, placebo controlled trial. Br J Psychiatry 1996;168:149–57CrossRefPubMed
28.
Zurück zum Zitat Raij MA, Brady SR. mirtazapine for treatment of depression and comorbidities in Alzheimer disease. Ann Pharmacother 2001; 35:1024–7CrossRef Raij MA, Brady SR. mirtazapine for treatment of depression and comorbidities in Alzheimer disease. Ann Pharmacother 2001; 35:1024–7CrossRef
29.
Zurück zum Zitat Bailer U, fischer P, Küfferle B, Stastny J, et al. Occurence of mirtazapin- induced delirium in organic brain disorder. Int Clin Psychopharmacol 2000;15,239–43CrossRefPubMed Bailer U, fischer P, Küfferle B, Stastny J, et al. Occurence of mirtazapin- induced delirium in organic brain disorder. Int Clin Psychopharmacol 2000;15,239–43CrossRefPubMed
30.
Zurück zum Zitat Tariot PN, Erb R, Podgorski CA, et al.: Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry 1998; 155: 54–61.CrossRefPubMed Tariot PN, Erb R, Podgorski CA, et al.: Efficacy and tolerability of carbamazepine for agitation and aggression in dementia. Am J Psychiatry 1998; 155: 54–61.CrossRefPubMed
31.
Zurück zum Zitat Lonergan E, Luxenberg J: Valproate preparations for agitation in dementia. Cochrane Database Syst Rev 2009 (3): CD003945. Lonergan E, Luxenberg J: Valproate preparations for agitation in dementia. Cochrane Database Syst Rev 2009 (3): CD003945.
32.
Zurück zum Zitat Vidal JS, Lacombe JM, dartques JF, Pasquier F, et al.: Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology 2008;31:193–200CrossRefPubMed Vidal JS, Lacombe JM, dartques JF, Pasquier F, et al.: Evaluation of the impact of memantine treatment initiation on psychotropics use: a study from the French national health care database. Neuroepidemiology 2008;31:193–200CrossRefPubMed
33.
Zurück zum Zitat Altýnyazar V, Kiylioglu N: Insomnia and dementia: is agomelatine treatment helpful? Case report and review of the literature. Ther Adv Psychopharmacol. 2016 Aug;6(4):263–8CrossRef Altýnyazar V, Kiylioglu N: Insomnia and dementia: is agomelatine treatment helpful? Case report and review of the literature. Ther Adv Psychopharmacol. 2016 Aug;6(4):263–8CrossRef
34.
Zurück zum Zitat Pompanin S, Jelcic N, Cecchin D, Cagnin A: Impulse control disorders in frontotemporal dementia: spectrum of symptoms and response to treatment. Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):760CrossRefPubMed Pompanin S, Jelcic N, Cecchin D, Cagnin A: Impulse control disorders in frontotemporal dementia: spectrum of symptoms and response to treatment. Gen Hosp Psychiatry. 2014 Nov-Dec;36(6):760CrossRefPubMed
35.
Zurück zum Zitat Yeh YC, Ouyang WC: Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review. Kaohsiung J Med Sci 2012 Apr;28(4):185–93CrossRefPubMed Yeh YC, Ouyang WC: Mood stabilizers for the treatment of behavioral and psychological symptoms of dementia: an update review. Kaohsiung J Med Sci 2012 Apr;28(4):185–93CrossRefPubMed
36.
Zurück zum Zitat Cooney C, Murphy S, Tessema H, Freyne A. Use of low dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia. J Neuropsychiatry Clin Neurosci. 2013 Spring;25(2):120–5CrossRefPubMed Cooney C, Murphy S, Tessema H, Freyne A. Use of low dose gabapentin for aggressive behavior in vascular and Mixed Vascular/Alzheimer Dementia. J Neuropsychiatry Clin Neurosci. 2013 Spring;25(2):120–5CrossRefPubMed
37.
Zurück zum Zitat Lonergan E, Luxemburg J. Valproate preparations for agitation in dementia,. Cochrane Database Syst Rev 2009; CD003945 Lonergan E, Luxemburg J. Valproate preparations for agitation in dementia,. Cochrane Database Syst Rev 2009; CD003945
38.
Zurück zum Zitat Sommer OH, Aga O, Cvancarova M, Olsen IC, Selbaek G, Engedal K. Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. Dement Geriatr Cogn Disord. 2009;27(2):155–63.CrossRefPubMed Sommer OH, Aga O, Cvancarova M, Olsen IC, Selbaek G, Engedal K. Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. Dement Geriatr Cogn Disord. 2009;27(2):155–63.CrossRefPubMed
39.
Zurück zum Zitat Gallagher D1, Herrmann N. Antiepileptic drugs for the treatment of agitation and aggression in dementia: do they have a place in therapy? Drugs. 2014 Oct;74(15):1747–55.CrossRefPubMed Gallagher D1, Herrmann N. Antiepileptic drugs for the treatment of agitation and aggression in dementia: do they have a place in therapy? Drugs. 2014 Oct;74(15):1747–55.CrossRefPubMed
40.
Zurück zum Zitat Alkhalil C, Tanvir F, Alkhalil B, Lowenthal DT. Treatment of sexual disinhibition in dementia: case reports and review of the literature. Am J Ther 2004; 11:231–5CrossRefPubMed Alkhalil C, Tanvir F, Alkhalil B, Lowenthal DT. Treatment of sexual disinhibition in dementia: case reports and review of the literature. Am J Ther 2004; 11:231–5CrossRefPubMed
41.
Zurück zum Zitat Leong C, Antidepressants for depression in patients with dementia: a review of the literature.Consult Pharm. 2014 Apr;29(4):254–63 Leong C, Antidepressants for depression in patients with dementia: a review of the literature.Consult Pharm. 2014 Apr;29(4):254–63
42.
Zurück zum Zitat Mizukami K1, Hatanaka K, Tanaka Y, Sato S, Asada TTherapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):349–52CrossRefPubMed Mizukami K1, Hatanaka K, Tanaka Y, Sato S, Asada TTherapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Mar 17;33(2):349–52CrossRefPubMed
43.
Zurück zum Zitat Nardell M, Tampi RR. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):123–32CrossRefPubMed Nardell M, Tampi RR. Pharmacological treatments for frontotemporal dementias: a systematic review of randomized controlled trials. Am J Alzheimers Dis Other Demen. 2014 Mar;29(2):123–32CrossRefPubMed
44.
Zurück zum Zitat Kishi T, Matsunaga S, Iwata N, Memantine for the treatment of frontotemporal dementia: a meta-analysis. Neuropsychiatr Dis Treat. 2015 Nov 12;11:2883–5CrossRef Kishi T, Matsunaga S, Iwata N, Memantine for the treatment of frontotemporal dementia: a meta-analysis. Neuropsychiatr Dis Treat. 2015 Nov 12;11:2883–5CrossRef
45.
Zurück zum Zitat Husebo BS, Ballard C, Fritze F, Sandvik RK, Aarsland D, Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial. Int J Geriatr Psychiatry. 2014 Aug;29(8):828–36CrossRefPubMed Husebo BS, Ballard C, Fritze F, Sandvik RK, Aarsland D, Efficacy of pain treatment on mood syndrome in patients with dementia: a randomized clinical trial. Int J Geriatr Psychiatry. 2014 Aug;29(8):828–36CrossRefPubMed
46.
Zurück zum Zitat Riemersma-van der Lek RF, Swaab DF, Twisk J, et al.: Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 2008; 299: 2642–2655.CrossRefPubMed Riemersma-van der Lek RF, Swaab DF, Twisk J, et al.: Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA 2008; 299: 2642–2655.CrossRefPubMed
47.
Zurück zum Zitat Dowling GA, Burr RL, Van Someren EJ, et al.: Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr Soc 2008; 56: 239–246.CrossRefPubMed Dowling GA, Burr RL, Van Someren EJ, et al.: Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr Soc 2008; 56: 239–246.CrossRefPubMed
48.
Zurück zum Zitat Serfaty M, Kennell-Webb S, Warner J, et al.: Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 2002; 17: 1120–1127.CrossRefPubMed Serfaty M, Kennell-Webb S, Warner J, et al.: Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 2002; 17: 1120–1127.CrossRefPubMed
49.
Zurück zum Zitat Singer C, Tractenberg RE, Kaye J, et al.: A multicenter, placebo-controlled trial of melatonin for sleepdisturbance in Alzheimer’s disease. Sleep 2003; 26: 893–901.CrossRefPubMedPubMedCentral Singer C, Tractenberg RE, Kaye J, et al.: A multicenter, placebo-controlled trial of melatonin for sleepdisturbance in Alzheimer’s disease. Sleep 2003; 26: 893–901.CrossRefPubMedPubMedCentral
50.
Zurück zum Zitat Liu CS, Chau SA, Ruthirakuhan M, Lanctôt KL, Herrmann N.Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease. CNS Drugs. 2015 Aug;29(8):615–23CrossRefPubMed Liu CS, Chau SA, Ruthirakuhan M, Lanctôt KL, Herrmann N.Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease. CNS Drugs. 2015 Aug;29(8):615–23CrossRefPubMed
51.
Zurück zum Zitat van den Elsen GA, Ahmed AI, Verkes RJ, Feuth T, van der Marck MA, Olde Rikkert MG. Tetrahydrocannabinol in Behavioral Disturbances in Dementia: A Crossover Randomized Controlled Trial. Am J Geriatr Psychiatry. 2015 Dec;23(12):1214–24CrossRefPubMed van den Elsen GA, Ahmed AI, Verkes RJ, Feuth T, van der Marck MA, Olde Rikkert MG. Tetrahydrocannabinol in Behavioral Disturbances in Dementia: A Crossover Randomized Controlled Trial. Am J Geriatr Psychiatry. 2015 Dec;23(12):1214–24CrossRefPubMed
52.
Zurück zum Zitat Panza F, Solfrizzi V, Seripa D, Imbimbo BP, Santamato A, Lozupone M, Prete C7, Greco A, Pilotto A, Logroscino G. Progresses in treating agitation: a major clinical challenge in Alzheimer’s disease. Expert Opin Pharmacother. 2015;16(17):2581–8CrossRefPubMed Panza F, Solfrizzi V, Seripa D, Imbimbo BP, Santamato A, Lozupone M, Prete C7, Greco A, Pilotto A, Logroscino G. Progresses in treating agitation: a major clinical challenge in Alzheimer’s disease. Expert Opin Pharmacother. 2015;16(17):2581–8CrossRefPubMed
53.
Zurück zum Zitat Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer’s disease. Expert Opin Pharmacother. 2017 Apr;18(6):611–620CrossRefPubMed Porsteinsson AP, Antonsdottir IM. An update on the advancements in the treatment of agitation in Alzheimer’s disease. Expert Opin Pharmacother. 2017 Apr;18(6):611–620CrossRefPubMed
54.
Zurück zum Zitat Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, Raskind MA, Peskind ER. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry. 2009 Sep;17(9):744–51CrossRefPubMedPubMedCentral Wang LY, Shofer JB, Rohde K, Hart KL, Hoff DJ, McFall YH, Raskind MA, Peskind ER. Prazosin for the treatment of behavioral symptoms in patients with Alzheimer disease with agitation and aggression. Am J Geriatr Psychiatry. 2009 Sep;17(9):744–51CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, De La Gandara JE, Agronin M, Davis CS, Nguyen U, Shin P, Tariot PN, Siffert J. Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29;314(12):1242–54CrossRefPubMed Cummings JL, Lyketsos CG, Peskind ER, Porsteinsson AP, Mintzer JE, Scharre DW, De La Gandara JE, Agronin M, Davis CS, Nguyen U, Shin P, Tariot PN, Siffert J. Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial. JAMA. 2015 Sep 22-29;314(12):1242–54CrossRefPubMed
56.
Zurück zum Zitat Sauve W. Recognizing and treating pseudobulbar affect. CNS Spectrums, 2016, 21(S1) 34–44. doi:10.1017/S1092852916000791CrossRefPubMed Sauve W. Recognizing and treating pseudobulbar affect. CNS Spectrums, 2016, 21(S1) 34–44. doi:10.1017/S1092852916000791CrossRefPubMed
57.
Zurück zum Zitat Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis J Alzheimers Dis. 2015;43(2):589–603PubMed Tan MS, Yu JT, Tan CC, Wang HF, Meng XF, Wang C, Jiang T, Zhu XC, Tan Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis J Alzheimers Dis. 2015;43(2):589–603PubMed
58.
Zurück zum Zitat Ihl R, Bachinskaya N, Korczyn AD, et al.: Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J GeriatrPsychiatry 2011; 26: 1186–1194 Ihl R, Bachinskaya N, Korczyn AD, et al.: Efficacy and safety of a once-daily formulation of Ginkgo biloba extract EGb 761 in dementia with neuropsychiatric features: a randomized controlled trial. Int J GeriatrPsychiatry 2011; 26: 1186–1194
59.
Zurück zum Zitat Ihl R, Tribanek M, Bachinskaya N et al.: Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer’s disease and vascular dementia: results from a randomized controlled trial. Pharmacopsychiatry 2012; 45: 41–46CrossRefPubMed Ihl R, Tribanek M, Bachinskaya N et al.: Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer’s disease and vascular dementia: results from a randomized controlled trial. Pharmacopsychiatry 2012; 45: 41–46CrossRefPubMed
60.
Zurück zum Zitat Herrschaft H, Nacu A, Likhachev S, et al.: Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res 2012; 46: 716–723CrossRefPubMed Herrschaft H, Nacu A, Likhachev S, et al.: Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. J Psychiatr Res 2012; 46: 716–723CrossRefPubMed
61.
Zurück zum Zitat arznei-telegramm® 2013; Jg. 44, Nr. 11 arznei-telegramm® 2013; Jg. 44, Nr. 11
Metadaten
Titel
Patienten mit Demenz
Medikamentöse Alternativen zu Antipsychotika bei Verhaltensstörungen
verfasst von
Dr. med. Johannes Rosenboom
Publikationsdatum
03.10.2017
Verlag
Springer Medizin
Erschienen in
DNP – Die Neurologie & Psychiatrie / Ausgabe 9-10/2017
Print ISSN: 2731-8168
Elektronische ISSN: 2731-8176
DOI
https://doi.org/10.1007/s15202-017-1504-2

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