Ausgabe 1/2015
Inhalt (156 Artikel)
Genome-wide mRNA expression profiling in vastus lateralis of COPD patients with low and normal fat free mass index and healthy controls
Roberto A Rabinovich, Ellen Drost, Jonathan R Manning, Donald R Dunbar, MaCarmen Díaz-Ramos, Ramzi Lakhdar, Ricardo Bastos, William MacNee
Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes
Greg Hodge, Hubertus Jersmann, Hai B Tran, Mark Holmes, Paul N Reynolds, Sandra Hodge
Sleepiness, inflammation and oxidative stress markers in middle-aged males with obstructive sleep apnea without metabolic syndrome: a cross-sectional study
Daniela Kuguimoto Andaku, Vânia D’Almeida, Gláucia Carneiro, Sônia Hix, Sergio Tufik, Sônia Maria Togeiro
Conditional overexpression of TGFβ1 promotes pulmonary inflammation, apoptosis and mortality via TGFβR2 in the developing mouse lung
Angara Sureshbabu, Mansoor A Syed, Chandra Sekhar Boddupalli, Madhav V Dhodapkar, Robert J Homer, Parviz Minoo, Vineet Bhandari
Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β
Peng Gao, Peter G Gibson, Katherine J Baines, Ian A Yang, John W Upham, Paul N Reynolds, Sandra Hodge, Alan L James, Christine Jenkins, Matthew J Peters, Jie Zhang, Jodie L Simpson
Increased in vivo mitochondrial oxygenation with right ventricular failure induced by pulmonary arterial hypertension: mitochondrial inhibition as driver of cardiac failure?
Gianmarco M Balestra, Egbert G Mik, Otto Eerbeek, Patricia AC Specht, Willem J van der Laarse, Coert J Zuurbier
Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma
David Gendron, Anne-Marie Lemay, Claudine Tremblay, Laetitia JA Lai, Anick Langlois, Émilie Bernatchez, Nicolas Flamand, Marie-Renée Blanchet, Anthony S Don, Ynuk Bossé, Élyse Bissonnette, David Marsolais
Long term effects of an integrated care intervention on hospital utilization in patients with severe COPD: a single centre controlled study
Elena Titova, Sigurd Steinshamn, Bent Indredavik, Anne Hildur Henriksen
Reviewer acknowledgement 2014
Jan Lötvall, Reynold A Panettieri
The role of IL-27 in susceptibility to post-influenza Staphylococcus aureus pneumonia
Keven M Robinson, Benjamin Lee, Erich V Scheller, Sivanarayana Mandalapu, Richard I Enelow, Jay K Kolls, John F Alcorn
MMP-12-mediated by SARM-TRIF signaling pathway contributes to IFN-γ-independent airway inflammation and AHR post RSV infection in nude mice
Xiaoru Long, Simin Li, Jun Xie, Wei Li, Na Zang, Luo Ren, Yu Deng, Xiaohong Xie, Lijia Wang, Zhou Fu, Enmei Liu
Roflumilast improves corticosteroid resistance COPD bronchial epithelial cells stimulated with toll like receptor 3 agonist
Javier Milara, Anselm Morell, Bea Ballester, Celia Sanz, Jose Freire, Xiaozhong Qian, Maggie Alonso-Garcia, Esteban Morcillo, Julio Cortijo
Denatonium inhibits growth and induces apoptosis of airway epithelial cells through mitochondrial signaling pathways
Xiaoxing Wen, Jian Zhou, Dan Zhang, Jing Li, Qin Wang, Nana Feng, Haixing Zhu, Yuanlin Song, Huayin Li, Chunxue Bai
Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M
Karen Kwofie, Matthew Scott, Rebecca Rodrigues, Jessica Guerette, Katherine Radford, Parameswaran Nair, Carl D Richards
Lung inflammatory pattern and antibiotic treatment in pneumonia
María-José Lorenzo, Inés Moret, Benjamín Sarria, Enrique Cases, Julio Cortijo, Raúl Méndez, Jose Molina, Alejandra Gimeno, Rosario Menéndez
Lung function, symptoms and inflammation during exacerbations of non-cystic fibrosis bronchiectasis: a prospective observational cohort study
Simon E Brill, Anant RC Patel, Richa Singh, Alexander J Mackay, Jeremy S Brown, John R Hurst
Dietary galacto-oligosaccharides prevent airway eosinophilia and hyperresponsiveness in a murine house dust mite-induced asthma model
Kim AT Verheijden, Linette EM Willemsen, Saskia Braber, Thea Leusink-Muis, Dianne JM Delsing, Johan Garssen, Aletta D Kraneveld, Gert Folkerts
Chronic exposure of diesel exhaust particles induces alveolar enlargement in mice
Kelly Yoshizaki, Jôse Mára Brito, Henrique T Moriya, Alessandra C Toledo, Sandra Ferzilan, Ana Paula Ligeiro de Oliveira, Isabel D Machado, Sandra HP Farsky, Luiz FF Silva, Milton A Martins, Paulo HN Saldiva, Thais Mauad, Mariangela Macchione
Imbalance of dendritic cell co-stimulation in COPD
Paul Stoll, Martin Ulrich, Kai Bratke, Katharina Garbe, J Christian Virchow, Marek Lommatzsch
A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids
Christian Vogelberg, Petra Moroni-Zentgraf, Migle Leonaviciute-Klimantaviciene, Ralf Sigmund, Eckard Hamelmann, Michael Engel, Stanley Szefler
Fibroblast-myofibroblast transition is differentially regulated by bronchial epithelial cells from asthmatic children
Stephen R Reeves, Tessa Kolstad, Tin-Yu Lien, Sarah Herrington-Shaner, Jason S Debley
Transcription factor and microRNA interactions in lung cells: an inhibitory link between NK2 homeobox 1, miR-200c and the developmental and oncogenic factors Nfib and Myb
Jean-Bosco Tagne, Omar R Mohtar, Joshua D Campbell, Meenakshi Lakshminarayanan, Jingshu Huang, Anne C Hinds, Jining Lu, Maria I Ramirez
Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers
Alejandro A Diaz, Farbod N Rahaghi, James C Ross, Rola Harmouche, Juerg Tschirren, Raul San José Estépar, George R Washko
Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation
Nikolaos Manitsopoulos, Stylianos E Orfanos, Anastasia Kotanidou, Ioanna Nikitopoulou, Ilias Siempos, Christina Magkou, Ioanna Dimopoulou, Spyros G Zakynthinos, Apostolos Armaganidis, Nikolaos A Maniatis
Once-daily fluticasone furoate/vilanterol 100/25 mcg versus twice daily combination therapies in COPD – mixed treatment comparisons of clinical efficacy
Gillian Stynes, Henrik Svedsater, Jaro Wex, Sally Lettis, David Leather, Emanuela Castelnuovo, Michelle Detry, Scott Berry
Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
Jie Xu, Gurpreet K Singhera, Delbert R Dorscheid
Changes in the endurance shuttle walk test in COPD patients with chronic respiratory failure after pulmonary rehabilitation: the minimal important difference obtained with anchor- and distribution-based method
Wytske A Altenburg, Marieke L Duiverman, Nick HT ten Hacken, Huib AM Kerstjens, Mathieu HG de Greef, Peter J Wijkstra, Johan B Wempe
Serum metalloproteinase-9 is related to COPD severity and symptoms - cross-sectional data from a population based cohort-study
Robert Linder, Eva Rönmark, Jamshid Pourazar, Annelie Behndig, Anders Blomberg, Anne Lindberg
Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome
Melissa A Kovach, Kathleen A Stringer, Rachel Bunting, Xiaoying Wu, Lani San Mateo, Michael W Newstead, Robert Paine III, Theodore J Standiford
Tight junction disruption by cadmium in an in vitro human airway tissue model
Xuefei Cao, Haixia Lin, Levan Muskhelishvili, John Latendresse, Patricia Richter, Robert H Heflich
Gait mechanics in patients with chronic obstructive pulmonary disease
Jennifer M Yentes, Kendra K Schmid, Daniel Blanke, Debra J Romberger, Stephen I Rennard, Nicholas Stergiou
Fracture prevention in COPD patients; a clinical 5-step approach
Elisabeth APM Romme, Piet Geusens, Willem F Lems, Erica PA Rutten, Frank WJM Smeenk, Joop PW van den Bergh, Peter ThW van Hal, Emiel FM Wouters
High definition bronchoscopy: a randomized exploratory study of diagnostic value compared to standard white light bronchoscopy and autofluorescence bronchoscopy
Erik HFM van der Heijden, Wouter Hoefsloot, Hieronymus WH van Hees, Olga CJ Schuurbiers
Capillary pCO2 helps distinguishing idiopathic pulmonary arterial hypertension from pulmonary hypertension due to heart failure with preserved ejection fraction
Karen M Olsson, Lisa Sommer, Jan Fuge, Tobias Welte, Marius M Hoeper
A randomized controlled trial of vitamin E and selenium on rate of decline in lung function
Patricia A Cassano, Kristin A Guertin, Alan R Kristal, Kathryn E Ritchie, Monica L Bertoia, Kathryn B Arnold, John J Crowley, JoAnn Hartline, Phyllis J Goodman, Catherine M Tangen, Lori M Minasian, Scott M Lippman, Eric Klein
Erratum: Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study
Elina MS Paaso, Maritta S Jaakkola, Aino K Rantala, Timo T Hugg, Jouni JK Jaakkola
Cigarette smoke inhibits BAFF expression and mucosal immunoglobulin A responses in the lung during influenza virus infection
Jianmiao Wang, Qinghai Li, Jungang Xie, Yongjian Xu
Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis
Ellen De Langhe, Frederic Cailotto, Vanessa De Vooght, Carolina Aznar-Lopez, Jeroen Alfons Vanoirbeek, Frank Prosper Luyten, Rik Jozef Urbain Lories
IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model
Xiujuan Yao, Wei Wang, Yan Li, Ping Huang, Qian Zhang, Jingjing Wang, Wen Wang, Zhe Lv, Yunqing An, Jianguo Qin, Chris J Corrigan, Kewu Huang, Yongchang Sun, Sun Ying
Prevalence of chronic obstructive pulmonary disease and variation in risk factors across four geographically diverse resource-limited settings in Peru
Devan Jaganath, J Jaime Miranda, Robert H Gilman, Robert A Wise, Gregory B Diette, Catherine H Miele, Antonio Bernabe-Ortiz, William Checkley
Cigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in mice
Meike Voss, Bodo Wonnenberg, Anja Honecker, Andreas Kamyschnikow, Christian Herr, Markus Bischoff, Thomas Tschernig, Robert Bals, Christoph Beisswenger
Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration
Heidi C Schilter, Adam Collison, Remo C Russo, Jonathan S Foot, Tin T Yow, Angelica T Vieira, Livia D Tavares, Joerg Mattes, Mauro M Teixeira, Wolfgang Jarolimek
Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury
Yali Zhang, Dandan Liang, Lili Dong, Xiangting Ge, Fengli Xu, Wenbo Chen, Yuanrong Dai, Huameng Li, Peng Zou, Shulin Yang, Guang Liang
National trends in emergency room diagnosis of pulmonary embolism, 2001–2010: a cross-sectional study
Andrew J Schissler, Anna Rozenshtein, Neil W Schluger, Andrew J Einstein
Megakaryoblastic leukemia-1 is required for the development of bleomycin-induced pulmonary fibrosis
Ksenija Bernau, Caitlyn Ngam, Elizabeth E Torr, Benjamin Acton, Jacob Kach, Nickolai O Dulin, Nathan Sandbo
Is arginase a potential drug target in tobacco-induced pulmonary endothelial dysfunction?
Priscilla Henno, Christelle Maurey, Françoise Le Pimpec-Barthes, Philippe Devillier, Christophe Delclaux, Dominique Israël-Biet
Mitochondrial DNA alteration in obstructive sleep apnea
Donato Lacedonia, Giovanna E Carpagnano, Elisabetta Crisetti, Grazia Cotugno, Grazia P Palladino, Giulia Patricelli, Roberto Sabato, Maria P Foschino Barbaro
TWEAK enhances TGF-β-induced epithelial-mesenchymal transition in human bronchial epithelial cells
Yukinari Itoigawa, Norihiro Harada, Sonoko Harada, Yoko Katsura, Fumihiko Makino, Jun Ito, Fariz Nurwidya, Motoyasu Kato, Fumiyuki Takahashi, Ryo Atsuta, Kazuhisa Takahashi
Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline
Jungang Xie, Hongxu Wu, Yuzhu Xu, Xiaojie Wu, Xue Liu, Jin Shang, Jianping Zhao, Junling Zhao, Jianmiao Wang, Charles S Dela Cruz, Weining Xiong, Yongjian Xu
Derivation and validation of clinical phenotypes for COPD: a systematic review
Lancelot M Pinto, Majed Alghamdi, Andrea Benedetti, Tasneem Zaihra, Tara Landry, Jean Bourbeau
Astragalin inhibits autophagy-associated airway epithelial fibrosis
In-Hee Cho, Yean-Jung Choi, Ju-Hyun Gong, Daekeun Shin, Min-Kyung Kang, Young-Hee Kang
Comparative effectiveness of budesonide/formoterol combination and fluticasone/salmeterol combination among chronic obstructive pulmonary disease patients new to controller treatment: a US administrative claims database study
David M Kern, Jill Davis, Setareh A Williams, Ozgur Tunceli, Bingcao Wu, Sally Hollis, Charlie Strange, Frank Trudo
Early detection of central lung cancer: are we there yet?
Ali I Musani, Akrum Al-Zubaidi
Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression
Jared A Sheridan, Michela Zago, Parameswaran Nair, Pei Z Li, Jean Bourbeau, Wan C Tan, Qutayba Hamid, David H Eidelman, Andrea L Benedetti, Carolyn J Baglole
Airway-centered interstitial fibrosis: etiology, clinical findings and prognosis
Lilian Tiemi Kuranishi, Kevin O Leslie, Rimarcs Gomes Ferreira, Ester Aparecida Ney Coletta, Karin Mueller Storrer, Maria Raquel Soares, Carlos Alberto de Castro Pereira
Sleep-disordered breathing and asthma: evidence from a large multicentric epidemiological study in China
Liwen Li, Zhiwei Xu, Xingming Jin, Chonghuai Yan, Fan Jiang, Shilu Tong, Xiaoming Shen, Shenghui Li
Periostin: its role in asthma and its potential as a diagnostic or therapeutic target
Wei Li, Peng Gao, Yue Zhi, Wei Xu, Yanfeng Wu, Jinzhi Yin, Jie Zhang
RETRACTED ARTICLE: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
Changping Gu, Mengjie Liu, Tao Zhao, Dong Wang, Yuelan Wang
Neutrophil extracellular trap (NET) formation characterises stable and exacerbated COPD and correlates with airflow limitation
Fikreta Grabcanovic-Musija, Astrid Obermayer, Walter Stoiber, Wolf-Dietrich Krautgartner, Peter Steinbacher, Nicole Winterberg, Arne Cornelius Bathke, Michaela Klappacher, Michael Studnicka
Mechanotransduction via TRPV4 regulates inflammation and differentiation in fetal mouse distal lung epithelial cells
Pritha S. Nayak, Yulian Wang, Tanbir Najrana, Lauren M. Priolo, Mayra Rios, Sunil K. Shaw, Juan Sanchez-Esteban
Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung
Robert Matthew Kottmann, Jesse Sharp, Kristina Owens, Peter Salzman, Guang-Qian Xiao, Richard P. Phipps, Patricia J. Sime, Edward B. Brown, Seth W. Perry
Measurement of C-reactive protein, procalcitonin and neutrophil elastase in saliva of COPD patients and healthy controls: correlation to self-reported wellbeing parameters
Neil Patel, John Belcher, Gary Thorpe, Nicholas R Forsyth, Monica A Spiteri
“Data safety and monitoring board in non-industry trials: learning it the hard way”
A. Hazenberg, H. A. M. Kerstjens, P. J. Wijkstra
Nanotechnology in respiratory medicine
Albert Joachim Omlor, Juliane Nguyen, Robert Bals, Quoc Thai Dinh
Cardiac safety of tiotropium in patients with cardiac events: a retrospective analysis of the UPLIFT® trial
Donald P Tashkin, Inge Leimer, Norbert Metzdorf, Marc Decramer
Epigenetics of Notch1 regulation in pulmonary microvascular rarefaction following extrauterine growth restriction
Li-Li Tang, Li-Yan Zhang, Lin-Jiang Lao, Qiong-Yao Hu, Wei-Zhong Gu, Lin-Chen Fu, Li-Zhong Du
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression
Aliaksei Z. Holik, Caitlin E. Filby, Julie Pasquet, Kati Viitaniemi, John Ciciulla, Kate D. Sutherland, Marie-Liesse Asselin-Labat
V0162 a new long-acting bronchodilator for treatment of chronic obstructive lung diseases: preclinical and clinical results
Philippe Devillier, Eric Garrigue, Guillaume D’Auzers, Nicolas Monjotin, Thomas Similowski, Thierry Clerc
Accelerated extracellular matrix turnover during exacerbations of COPD
Jannie M. B. Sand, Alan J. Knox, Peter Lange, Shu Sun, Jacob H. Kristensen, Diana J. Leeming, Morten A. Karsdal, Charlotte E. Bolton, Simon R. Johnson
The vectorial transport of salts and water is crucial for respiratory epithelial cell lines
Khaled Khoufache
Influence of weather and atmospheric pollution on physical activity in patients with COPD
Ayedh D. Alahmari, Alex J. Mackay, Anant R.C. Patel, Beverly S. Kowlessar, Richa Singh, Simon E. Brill, James P. Allinson, Jadwiga A. Wedzicha, Gavin C. Donaldson
Fibroblast-epithelial cell interactions drive epithelial-mesenchymal transition differently in cells from normal and COPD patients
Michiyoshi Nishioka, Narayanan Venkatesan, Kevin Dessalle, Andrea Mogas, Shigenori Kyoh, Ting-Yu Lin, Parameswaran Nair, Carolyn J. Baglole, David H. Eidelman, Mara S. Ludwig, Qutayba Hamid
6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells
Kondababu Kurakula, Anouk A. Hamers, Pieter van Loenen, Carlie J.M. de Vries
Differentially expressed and activated proteins associated with non small cell lung cancer tissues
E. Nigro, E. Imperlini, O. Scudiero, M.L. Monaco, R. Polito, G. Mazzarella, S. Orrù, A. Bianco, A. Daniele
Hyperoxia-induced methylation decreases RUNX3 in a newborn rat model of bronchopulmonary dysplasia
Yuting Zhu, Jianhua Fu, Haiping Yang, Yuqing Pan, Li Yao, Xindong Xue
Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients
Dorota Pastuszak-Lewandoska, Jacek Kordiak, Monika Migdalska-Sęk, Karolina H. Czarnecka, Adam Antczak, Paweł Górski, Ewa Nawrot, Justyna M. Kiszałkiewicz, Daria Domańska, Ewa Brzeziańska-Lasota
Protective effect of a Protein Epitope Mimetic CCR10 antagonist, POL7085, in a model of allergic eosinophilic airway inflammation
François Daubeuf, Françoise Jung, Garry J. Douglas, Eric Chevalier, Nelly Frossard
Acute exacerbations of COPD are associated with significant activation of matrix metalloproteinase 9 irrespectively of airway obstruction, emphysema and infection
Eleni Papakonstantinou, George Karakiulakis, Spyros Batzios, Spasenija Savic, Michael Roth, Michael Tamm, Daiana Stolz
A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases
Laura Taguchi, Nathalia M. Pinheiro, Clarice R. Olivo, Alessandra Choqueta-Toledo, Simone S. Grecco, Fernanda D.T.Q.S. Lopes, Luciana C. Caperuto, Mílton A. Martins, Iolanda F.L.C. Tiberio, Niels O. Câmara, João Henrique G. Lago, Carla M. Prado
Health-related quality of life in young adults with congenital central hypoventilation syndrome due to PHOX2B mutations: a cross-sectional study
Emilienne Verkaeren, Agnès Brion, Amélie Hurbault, Cécile Chenivesse, Capucine Morelot-Panzini, Jésus Gonzalez-Bermejo, Valérie Attali, Thomas Similowski, Christian Straus
Association of 25-Hydroxyvitamin D status and genetic variation in the vitamin D metabolic pathway with FEV1 in the Framingham Heart Study
JG Hansen, W Gao, J Dupuis, GT O’Connor, W Tang, M Kowgier, A Sood, SA Gharib, LJ Palmer, M Fornage, SR Heckbert, BM Psaty, SL Booth, Patricia A Cassano
Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices
Vanesa Vicens-Zygmunt, Susanna Estany, Adai Colom, Ana Montes-Worboys, Carlos Machahua, Andrea Juliana Sanabria, Roger Llatjos, Ignacio Escobar, Frederic Manresa, Jordi Dorca, Daniel Navajas, Jordi Alcaraz, Maria Molina-Molina
Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis
BreAnne MacKenzie, Martina Korfei, Ingrid Henneke, Zaneta Sibinska, Xia Tian, Stefanie Hezel, Salma Dilai, Roxana Wasnick, Beate Schneider, Jochen Wilhelm, Elie El Agha, Walter Klepetko, Werner Seeger, Ralph Schermuly, Andreas Günther, Saverio Bellusci
Determinants of an elevated pulmonary arterial pressure in patients with pulmonary arterial hypertension
Seiichiro Sakao, Norbert F. Voelkel, Nobuhiro Tanabe, Koichiro Tatsumi
Altered protease and antiprotease balance during a COPD exacerbation contributes to mucus obstruction
Shashi Chillappagari, Jenni Preuss, Sebastian Licht, Christian Müller, Poornima Mahavadi, Gaurav Sarode, Claus Vogelmeier, Andreas Guenther, Lutz Nahrlich, Bruce K. Rubin, Markus O. Henke
Evidence for a novel Kit adhesion domain mediating human mast cell adhesion to structural airway cells
Kevin C. Gough, Ben C. Maddison, Aarti Shikotra, Elena P. Moiseeva, Weidong Yang, Shila Jarvis, Peter Bradding
Randomised, double-blind, placebo-controlled crossover study to investigate different dosing regimens of olodaterol delivered via Respimat® in patients with moderate to severe persistent asthma
Kai-Michael Beeh, Craig LaForce, Martina Gahlemann, Arne Wenz, Robert Toorawa, Matjaž Fležar
Airways resistance and specific conductance for the diagnosis of obstructive airways diseases
Marko Topalovic, Eric Derom, Christian R. Osadnik, Thierry Troosters, Marc Decramer, Wim Janssens
Thoracic ultrasound for the diagnosis of pneumonia in adults: a meta-analysis
Thomas Berlet
Increased ectodomain shedding of cell adhesion molecule 1 as a cause of type II alveolar epithelial cell apoptosis in patients with idiopathic interstitial pneumonia
Azusa Yoneshige, Man Hagiyama, Takao Inoue, Takahiro Mimae, Takashi Kato, Morihito Okada, Eisuke Enoki, Akihiko Ito
Building a better neonatal mouse model to understand infant respiratory syncytial virus disease
Dahui You, David T. Siefker, Bishwas Shrestha, Jordy Saravia, Stephania A. Cormier
Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT)
Eric D. Bateman, Kenneth R. Chapman, Dave Singh, Anthony D. D’Urzo, Eduard Molins, Anne Leselbaum, Esther Garcia Gil
Plk1 regulates MEK1/2 and proliferation in airway smooth muscle cells
Sixin Jiang, Dale D. Tang
Acute exacerbations of chronic obstructive pulmonary disease are associated with decreased CD4+ & CD8+ T cells and increased growth & differentiation factor-15 (GDF-15) in peripheral blood
Christine M. Freeman, Carlos H. Martinez, Jill C. Todt, Fernando J. Martinez, MeiLan K. Han, Deborah L. Thompson, Lisa McCloskey, Jeffrey L. Curtis
Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects
Dorota Stefanowicz, Ja Young Lee, Kevin Lee, Furquan Shaheen, Hyun-Kyoung Koo, Steven Booth, Darryl A. Knight, Tillie-Louise Hackett
Quantitation of circulating wild-type alpha-1-antitrypsin in heterozygous carriers of the S and Z deficiency alleles
L. J. Donato, R. M. Karras, J. A. Katzmann, D. L. Murray, M. R. Snyder
Dose-finding evaluation of once-daily treatment with olodaterol, a novel long-acting β2-agonist, in patients with asthma: results of a parallel-group study and a crossover study
Paul M. O’Byrne, Tony D’Urzo, Ekkehard Beck, Matjaž Fležar, Martina Gahlemann, Lorna Hart, Zuzana Blahova, Robert Toorawa, Kai-Michael Beeh
The effects of corticosteroids on COPD lung macrophages: a pooled analysis
Andrew Higham, George Booth, Simon Lea, Thomas Southworth, Jonathan Plumb, Dave Singh
Bidirectional role of IL-6 signal in pathogenesis of lung fibrosis
Takeshi Kobayashi, Kensuke Tanaka, Tetsuo Fujita, Hiroki Umezawa, Hiroyuki Amano, Kento Yoshioka, Yusuke Naito, Masahiko Hatano, Sadao Kimura, Koichiro Tatsumi, Yoshitoshi Kasuya
Complementary roles of KCa3.1 channels and β1-integrin during alveolar epithelial repair
Alban Girault, Jasmine Chebli, Anik Privé, Nguyen Thu Ngan Trinh, Emilie Maillé, Ryszard Grygorczyk, Emmanuelle Brochiero
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in chronic obstructive pulmonary disease
Nawar Diar Bakerly, Ashley Woodcock, John P. New, J. Martin Gibson, Wei Wu, David Leather, Jørgen Vestbo
Bronchoabsorption; a novel bronchoscopic technique to improve biomarker sampling of the airway
BR Leaker, GC Nicholson, FY Ali, N Daudi, BJ O’Connor, PJ Barnes
Impaired cardiac and peripheral hemodynamic responses to inhaled β2-agonist in cystic fibrosis
Erik H. Van Iterson, Stephen R. Karpen, Sarah E. Baker, Courtney M. Wheatley, Wayne J. Morgan, Eric M. Snyder
Erratum to: Thoracic ultrasound for the diagnosis of pneumonia in adults: a meta-analysis
Thomas Berlet
Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis
Sanja Cicko, Melanie Grimm, Korcan Ayata, Jessica Beckert, Anja Meyer, Madelon Hossfeld, Gernot Zissel, Marco Idzko, Tobias Müller
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways
Robert H. Brown, Curt Reynolds, Allison Brooker, Paul Talalay, Jed W. Fahey
The Tiotropium Safety and Performance in Respimat® (TIOSPIR®) Trial: Spirometry Outcomes
Antonio Anzueto, Robert Wise, Peter Calverley, Daniel Dusser, Wenbo Tang, Norbert Metzdorf, Ronald Dahl
Impaired survival of regulatory T cells in pulmonary sarcoidosis
Caroline E. Broos, Menno van Nimwegen, Alex Kleinjan, Bregje ten Berge, Femke Muskens, Johannes C.C.M. in ’t Veen, Jouke T. Annema, Bart N. Lambrecht, Henk C. Hoogsteden, Rudi W. Hendriks, Mirjam Kool, Bernt van den Blink
Role of pulmonary microvascular endothelial cell apoptosis in murine sepsis-induced lung injury in vivo
Sean E. Gill, Marta Rohan, Sanjay Mehta
Vitamin D deficiency exacerbates COPD-like characteristics in the lungs of cigarette smoke-exposed mice
Nele Heulens, Hannelie Korf, Nele Cielen, Elien De Smidt, Karen Maes, Conny Gysemans, Erik Verbeken, Ghislaine Gayan-Ramirez, Chantal Mathieu, Wim Janssens
MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment
Jill A. Poole, Todd A. Wyatt, Debra J. Romberger, Elizabeth Staab, Samantha Simet, Stephen J. Reynolds, Joseph H. Sisson, Tammy Kielian
Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury
Li-Fu Li, Chung-Shu Lee, Yung-Yang Liu, Chih-Hao Chang, Chang-Wei Lin, Li-Chung Chiu, Kuo-Chin Kao, Ning-Hung Chen, Cheng-Ta Yang
Erratum: A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases
Laura Taguchi, Nathalia M. Pinheiro, Clarice R. Olivo, Alessandra Choqueta-Toledo, Simone S. Grecco, Fernanda D. T. Q. S. Lopes, Luciana C. Caperuto, Mílton A. Martins, Iolanda F. L. C. Tiberio, Niels O. Câmara, João Henrique G. Lago, Carla M. Prado
Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells
Laura C. Price, Dongmin Shao, Chao Meng, Frederic Perros, Benjamin E. Garfield, Jie Zhu, David Montani, Peter Dorfmuller, Marc Humbert, Ian M. Adcock, Stephen J. Wort
Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study
Lystra P. Hayden, Brian D. Hobbs, Robyn T. Cohen, Robert A. Wise, William Checkley, James D. Crapo, Craig P. Hersh
Safety, tolerability and appropriate use of nintedanib in idiopathic pulmonary fibrosis
Tamera Corte, Francesco Bonella, Bruno Crestani, Maurits G. Demedts, Luca Richeldi, Carl Coeck, Katy Pelling, Manuel Quaresma, Joseph A. Lasky
The lung response to ozone is determined by age and is partially dependent on toll-Like receptor 4
Kelsa Gabehart, Kelly A. Correll, Joan E. Loader, Carl W. White, Azzeddine Dakhama
BARD1 mediates TGF-β signaling in pulmonary fibrosis
Pierre-Alain André, Cecilia M. Prêle, Sarah Vierkotten, Stéphanie Carnesecchi, Yves Donati, Rachel C. Chambers, Jean-Claude Pache, Bruno Crestani, Constance Barazzone-Argiroffo, Melanie Königshoff, Geoffrey J. Laurent, Irmgard Irminger-Finger
Inhaled carbon monoxide protects time-dependently from loss of hypoxic pulmonary vasoconstriction in endotoxemic mice
Nora Jahn, Regis R. Lamberts, Cornelius J. Busch, Maria T. Voelker, Thilo Busch, Marleen J. A. Koel-Simmelink, Charlotte E. Teunissen, Daniel D. Oswald, Stephan A. Loer, Udo X. Kaisers, Jörg Weimann
Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis
Akihiko Sokai, Tomohiro Handa, Kiminobu Tanizawa, Toru Oga, Kazuko Uno, Tatsuaki Tsuruyama, Takeshi Kubo, Kohei Ikezoe, Yoshinari Nakatsuka, Kazuya Tanimura, Shigeo Muro, Toyohiro Hirai, Sonoko Nagai, Kazuo Chin, Michiaki Mishima
Efficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial
R. Eccles, B. Winther, S.L. Johnston, P. Robinson, M. Trampisch, S. Koelsch
Alveolar macrophages support interferon gamma-mediated viral clearance in RSV-infected neonatal mice
Katherine M. Eichinger, Loreto Egaña, Jacob G. Orend, Erin Resetar, Kacey B. Anderson, Ravi Patel, Kerry M. Empey
Prospectively defined murine mesenchymal stem cells inhibit Klebsiella pneumoniae-induced acute lung injury and improve pneumonia survival
Holger Hackstein, Anne Lippitsch, Philipp Krug, Inna Schevtschenko, Sabine Kranz, Matthias Hecker, Kristina Dietert, Achim D. Gruber, Gregor Bein, Cornelia Brendel, Nelli Baal
Down-regulation of USP13 mediates phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis
Jing Geng, Xiaoxi Huang, Ying Li, Xuefeng Xu, Shuhong Li, Dingyuan Jiang, Jiurong Liang, Dianhua Jiang, Chen Wang, Huaping Dai
Systematic review regarding metabolic profiling for improved pathophysiological understanding of disease and outcome prediction in respiratory infections
Manuela Nickler, Manuel Ottiger, Christian Steuer, Andreas Huber, Janet Byron Anderson, Beat Müller, Philipp Schuetz
Severity of hypoxia modulates effect of CPAP on myocardial stress as measured by highly sensitive troponin T
Amir Sharafkhaneh, Jennifer Katigbak, Max Hirshkowitz, Hossein Sharafkhaneh, Saba P. Sharafkhaneh, Christie M. Ballantyne, Biykem Bozkurt, Vijay Nambi
Increased S100A4 expression in the vasculature of human COPD lungs and murine model of smoke-induced emphysema
Sebastian Reimann, Ludger Fink, Jochen Wilhelm, Julia Hoffmann, Mariola Bednorz, Michael Seimetz, Isabel Dessureault, Roger Troesser, Bahil Ghanim, Walter Klepetko, Werner Seeger, Norbert Weissmann, Grazyna Kwapiszewska
Erratum to: A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids
Christian Vogelberg, Petra Moroni-Zentgraf, Migle Leonaviciute-Klimantaviciene, Ralf Sigmund, Eckard Hamelmann, Michael Engel, Stanley Szefler
TNFα-blockade stabilizes local airway hyperresponsiveness during TLR-induced exacerbations in murine model of asthma
Magnus Starkhammar, Susanna Kumlien Georén, Sven-Erik Dahlén, Lars-Olaf Cardell, Mikael Adner
Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes
Greg Hodge, Hubertus Jersmann, Hai B. Tran, Eugene Roscioli, Mark Holmes, Paul N. Reynolds, Sandra Hodge
Cigarette smoke differentially modulates dendritic cell maturation and function in time
Masoumeh Ezzati Givi, Gert Folkerts, Gerry T. M. Wagenaar, Frank A. Redegeld, Esmaeil Mortaz
Pharmacologically-induced mitotic synchrony in airway epithelial cells as a mechanism of action of anti-inflammatory drugs
R J Freishtat, G Nino, Y Tsegaye, S E Alcala, A S Benton, A M Watson, E K M Reeves, S K Haider, J M Damsker
Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
Michiko Mori, Leif Bjermer, Jonas S. Erjefält, Martin R. Stampfli, Abraham B. Roos
Roflumilast partially reverses smoke-induced mucociliary dysfunction
Andreas Schmid, Nathalie Baumlin, Pedro Ivonnet, John S. Dennis, Michael Campos, Stefanie Krick, Matthias Salathe
Erratum to: Fibroblast viability and phenotypic changes within glycated stiffened three-dimensional collagen matrices
Vanesa Vicens-Zygmunt, Susanna Estany, Adai Colom, Ana Montes-Worboys, Carlos Machahua, Andrea Juliana Sanabria, Roger Llatjos, Ignacio Escobar, Frederic Manresa, Jordi Dorca, Daniel Navajas, Jordi Alcaraz, Maria Molina-Molina
Acute hemodynamic effects of adaptive servoventilation in patients with pre-capillary and post-capillary pulmonary hypertension
Karen M. Olsson, Anika Frank, Jan Fuge, Tobias Welte, Marius M. Hoeper, Thomas Bitter
Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions
Jin Gu Lee, Ju Hye Shin, Hyo Sup Shim, Chang Young Lee, Dae Joon Kim, Young Sam Kim, Kyung Young Chung
Erratum to: Vitamin D regulating TGF-β induced epithelial-mesenchymal transition
Kimberly D. Fischer, Devendra K. Agrawal
Retinoic acid promotes the endogenous repair of lung stem/progenitor cells in combined with simvastatin after acute lung injury: a stereological analysis
Ce Yang, Xuetao Yang, Juan Du, Haiyan Wang, Haisheng Li, Ling Zeng, Wei Gu, Jianxin Jiang
Characteristics, disease burden and costs of COPD patients in the two years following initiation of long-acting bronchodilators in UK primary care
Yogesh Suresh Punekar, Sarah H Landis, Keele Wurst, Hoa Le
Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study
P. E. Silkoff, I. Strambu, M. Laviolette, D. Singh, J. M. FitzGerald, S. Lam, S. Kelsen, A. Eich, A. Ludwig-Sengpiel, G. C hupp, V. Backer, C. Porsbjerg, P. O. Girodet, P. Berger, R. Leigh, J. N. Kline, M. Dransfield, W. Calhoun, A. Hussaini, S. Khatri, P. Chanez, V. S. Susulic, E. S. Barnathan, M. Curran, A. M. Das, C. Brodmerkel, F. Baribaud, M. J. Loza
A pilot randomized controlled trial of pioglitazone for the treatment of poorly controlled asthma in obesity
Anne E. Dixon, Meenakumari Subramanian, Michael DeSarno, Kendall Black, Lisa Lane, Fernando Holguin
Investigating NF-κB signaling in lung fibroblasts in 2D and 3D culture systems
Su Su Htwe, Helen Harrington, Alan Knox, Felicity Rose, Jonathan Aylott, John W. Haycock, Amir M Ghaemmaghami
Health-related quality of life is inversely correlated with C-reactive protein and age in Mycobacterium avium complex lung disease: a cross-sectional analysis of 235 patients
Takanori Asakura, Yohei Funatsu, Makoto Ishii, Ho Namkoong, Kazuma Yagi, Shoji Suzuki, Takahiro Asami, Tetsuro Kamo, Hiroshi Fujiwara, Yoshifumi Uwamino, Tomoyasu Nishimura, Sadatomo Tasaka, Tomoko Betsuyaku, Naoki Hasegawa
RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema
Yoshiro Kai, Koichi Tomoda, Hiroyuki Yoneyama, Masanori Yoshikawa, Hiroshi Kimura
The whole - genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge
Joanna Wieczfinska, Dorota Kacprzak, Karolina Pospiech, Milena Sokolowska, Magdalena Nowakowska, Ewa Pniewska, Andrzej Bednarek, Izabela Kuprys–Lipinska, Piotr Kuna, Rafal Pawliczak
Association of elevated α-defensin levels with interstitial pneumonia in patients with systemic sclerosis
Noriho Sakamoto, Tomoyuki Kakugawa, Atsuko Hara, Shota Nakashima, Hirokazu Yura, Tatsuhiko Harada, Hiroshi Ishimoto, Kazuhiro Yatera, Yutaka Kuwatsuka, Toshihide Hara, Kunihiro Ichinose, Yasushi Obase, Yuji Ishimatsu, Shigeru Kohno, Hiroshi Mukae
Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis
Yu Fan, Ye Wang, Ke Wang
Mannose-binding lectin protein and its association to clinical outcomes in COPD: a longitudinal study
Jyotshna Mandal, Bijaya Malla, Rudi Steffensen, Luigi Costa, Adrian Egli, Marten Trendelenburg, Francesco Blasi, Kostantinos Kostikas, Tobias Welte, Antoni Torres, Renaud Louis, Wim Boersma, Branislava Milenkovic, Joachim Aerts, Gernot G. U. Rohde, Alicia Lacoma, Katharina Rentsch, Michael Roth, Michael Tamm, Daiana Stolz
A decision tree to assess short-term mortality after an emergency department visit for an exacerbation of COPD: a cohort study
Cristóbal Esteban, Inmaculada Arostegui, Susana Garcia-Gutierrez, Nerea Gonzalez, Iratxe Lafuente, Marisa Bare, Nerea Fernandez de Larrea, Francisco Rivas, José M. Quintana
Prenatal tobacco smoke exposure increases hospitalizations for bronchiolitis in infants
Marcello Lanari, Silvia Vandini, Fulvio Adorni, Federica Prinelli, Simona Di Santo, Michela Silvestri, Massimo Musicco
Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration
Walter Blum, László Pecze, Emanuela Felley-Bosco, Beat Schwaller
Regulation of YKL-40 expression by corticosteroids: effect on pro-inflammatory macrophages in vitro and its modulation in COPD in vivo
L. I. Z. Kunz, E. F. A. van’t Wout, A. van Schadewijk, D. S. Postma, H. A. M. Kerstjens, P. J. Sterk, P. S. Hiemstra
Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes
Fabien Pillard, Michel Lavit, Valérie Lauwers Cances, Jacques Rami, Georges Houin, Alain Didier, Daniel Rivière
Association between pulmonary function and peak oxygen uptake in elderly: the Generation 100 study
Erlend Hassel, Dorthe Stensvold, Thomas Halvorsen, Ulrik Wisløff, Arnulf Langhammer, Sigurd Steinshamn