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Zeitschrift

Respiratory Research

Respiratory Research 1/2016

Ausgabe 1/2016

Inhaltsverzeichnis ( 166 Artikel )

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Utilization due to chronic obstructive pulmonary disease and its predictors: a study using the U.S. National Emergency Department Sample (NEDS)

Jasvinder A. Singh, Shaohua Yu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Budesonide and fluticasone propionate differentially affect the airway epithelial barrier

I. H. Heijink, M. R. Jonker, M. de Vries, A. J. M. van Oosterhout, E. Telenga, N. H. T. ten Hacken, D. S. Postma, M. van den Berge

01.12.2016 | Research | Ausgabe 1/2016 Open Access

TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor

Winifred Broekman, Gimano D. Amatngalim, Yvonne de Mooij-Eijk, Jaap Oostendorp, Helene Roelofs, Christian Taube, Jan Stolk, Pieter S. Hiemstra

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1

Chunmin Dong, Rafael Gongora, Meredith L. Sosulski, Fayong Luo, Cecilia G. Sanchez

01.12.2016 | Research | Ausgabe 1/2016 Open Access

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Brittany M. Salter, John Paul Oliveria, Graeme Nusca, Steve G. Smith, Damian Tworek, Patrick D. Mitchell, Rick M. Watson, Roma Sehmi, Gail M. Gauvreau

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis

Rabih Halwani, Asma Sultana, Roua Al-Kufaidy, Amer Jamhawi, Alejandro Vazquez-Tello, Saleh Al-Muhsen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Possible role of Krüppel-like factor 5 in the remodeling of small airways and pulmonary vessels in chronic obstructive pulmonary disease

Kyoko Abe, Hisatoshi Sugiura, Yuichiro Hashimoto, Tomohiro Ichikawa, Akira Koarai, Mitsuhiro Yamada, Tadahisa Numakura, Katsuhiro Onodera, Rie Tanaka, Kei Sato, Satoru Yanagisawa, Tatsuma Okazaki, Tsutomu Tamada, Toshiaki Kikuchi, Masakazu Ichinose

01.12.2016 | Research | Ausgabe 1/2016 Open Access

c.3623G > A mutation encodes a CFTR protein with impaired channel function

Xiaoying Zhang, Jaspal S. Hothi, Yanhui H. Zhang, Saumini Srinivasan, Dennis C. Stokes, Weiqiang Zhang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells

Seamus Grundy, Jonathan Plumb, Manminder Kaur, David Ray, Dave Singh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Intralymphatic immunotherapy of pollen-induced rhinoconjunctivitis: a double-blind placebo-controlled trial

Terese Hylander, Olivia Larsson, Ulla Petersson-Westin, Mia Eriksson, Susanna Kumlien Georén, Ola Winqvist, Lars-Olaf Cardell

01.12.2016 | Editorial | Ausgabe 1/2016 Open Access

Absence of human rhinovirus and respiratory syncytial virus from bronchoalveolar lavage and bronchial biopsies of selected patients with stable chronic obstructive pulmonary disease

Styliani Giannakaki, Lida Politi, Elvira Markella Antonogiannaki, Nick Spanakis, Georgios Arsenis, Vasiliki Filaditaki, Spyridon Zakynthinos, Napoleon Karagiannidis, Athanassios Tsakris

01.12.2016 | Reviewer acknowledgement | Ausgabe 1/2016 Open Access

Reviewer acknowledgement 2015

Jan Lötvall, Reynold A. Panettieri

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Combination therapy of tiotropium and ciclesonide attenuates airway inflammation and remodeling in a guinea pig model of chronic asthma

Loes E. M. Kistemaker, I. Sophie T. Bos, Mark H. Menzen, Harm Maarsingh, Herman Meurs, Reinoud Gosens

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis

Siri T. Lehtonen, Anniina Veijola, Henna Karvonen, Elisa Lappi-Blanco, Raija Sormunen, Saara Korpela, Ulrika Zagai, Magnus C. Sköld, Riitta Kaarteenaho

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Soluble adenylyl cyclase mediates hydrogen peroxide-induced changes in epithelial barrier function

Pedro Ivonnet, Hoshang Unwalla, Matthias Salathe, Gregory E. Conner

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Screening and managing obstructive sleep apnoea in nocturnal heart block patients: an observational study

Xu Wu, Zilong Liu, Su Chi Chang, Cuiping Fu, Wenjing Li, Hong Jiang, Liyan Jiang, Shanqun Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) promotes lung fibroblast proliferation, survival and differentiation to myofibroblasts

Nadia A. Hasaneen, Jian Cao, Ashleigh Pulkoski-Gross, Stanley Zucker, Hussein D. Foda

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Can roflumilast, a phosphodiesterase-4 inhibitor, improve clinical outcomes in patients with moderate-to-severe chronic obstructive pulmonary disease? A meta-analysis

Jian Luo, Ke Wang, Dan Liu, Bin-Miao Liang, Chun-Tao Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice

Toru Kimura, Takashi Nojiri, Jun Hino, Hiroshi Hosoda, Koichi Miura, Yasushi Shintani, Masayoshi Inoue, Masahiro Zenitani, Hiroyuki Takabatake, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa

01.12.2016 | Editorial | Ausgabe 1/2016 Open Access

Endothelial to mesenchymal transition (EndMT): an active process in Chronic Obstructive Pulmonary Disease (COPD)?

Sukhwinder Singh Sohal

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CXCL13 in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

Karen M. Olsson, Sandra Olle, Jan Fuge, Tobias Welte, Marius M. Hoeper, Christian Lerch, Lavinia Maegel, Hermann Haller, Danny Jonigk, Lena Schiffer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Birt-Hogg-Dubé syndrome: a large single family cohort

Kate Skolnik, Willis H. Tsai, Kimberly Dornan, Renée Perrier, Paul W. Burrowes, Warren J. Davidson

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Role of matrix metalloproteinases in the pathogenesis of idiopathic pulmonary fibrosis

Annie Pardo, Sandra Cabrera, Mariel Maldonado, Moisés Selman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Diet-induced obesity alters myeloid cell populations in naïve and injured lung

Anne M. Manicone, Keqin Gong, Laura K. Johnston, Matthew Giannandrea

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The activation of M3 mAChR in airway epithelial cells promotes IL-8 and TGF-β1 secretion and airway smooth muscle cell migration

Juan-Juan Lu, Guang-Ni Xu, Ping Yu, Yun Song, Xiao-Lin Wang, Liang Zhu, Hong-Zhuan Chen, Yong-Yao Cui

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Exposure to urban PM1 in rats: development of bronchial inflammation and airway hyperresponsiveness

Ágnes Filep, Gergely H. Fodor, Fruzsina Kun-Szabó, László Tiszlavicz, Zsolt Rázga, Gábor Bozsó, Zoltán Bozóki, Gábor Szabó, Ferenc Peták

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Effect of tiotropium on night-time awakening and daily rescue medication use in patients with COPD

Peter M. A. Calverley, Stephen I. Rennard, Emmanuelle Clerisme-Beaty, Norbert Metzdorf, Valentina Bayer Zubek, Richard ZuWallack

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dipeptidyl peptidase-4 is highly expressed in bronchial epithelial cells of untreated asthma and it increases cell proliferation along with fibronectin production in airway constitutive cells

Taichi Shiobara, Kazuyuki Chibana, Taiji Watanabe, Ryo Arai, Yukiko Horigane, Yusuke Nakamura, Yumeko Hayashi, Yasuo Shimizu, Akihiro Takemasa, Yoshiki Ishii

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A randomized trial of the efficacy and safety of quilizumab in adults with inadequately controlled allergic asthma

Jeffrey M. Harris, Romeo Maciuca, Mary S. Bradley, Christopher R. Cabanski, Heleen Scheerens, Jeremy Lim, Fang Cai, Mona Kishnani, X. Charlene Liao, Divya Samineni, Rui Zhu, Colette Cochran, Weily Soong, Joseph D. Diaz, Patrick Perin, Miguel Tsukayama, Dimo Dimov, Ioana Agache, Steven G. Kelsen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity

Yoshiki Kobayashi, Kazuhiro Ito, Akira Kanda, Koich Tomoda, Anna Miller-Larsson, Peter J. Barnes, Nicolas Mercado

01.12.2016 | Research | Ausgabe 1/2016 Open Access

YKL-40 expression in chronic obstructive pulmonary disease: relation to acute exacerbations and airway remodeling

Tianwen Lai, Dong Wu, Min Chen, Chao Cao, Zhiliang Jing, Li Huang, Yingying Lv, Xuanna Zhao, Quanchao Lv, Yajun Wang, Dongming Li, Bin Wu, Huahao Shen

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

The cytokine interleukin-26 as a biomarker in pediatric asthma

Jon R. Konradsen, Björn Nordlund, Bettina Levänen, Gunilla Hedlin, Anders Linden

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The linear relationship between systolic pulmonary artery pressure and mean pulmonary artery pressure is maintained regardless of autonomic or rhythm disturbances

Frédéric Vanden Eynden, Judith Racapé, Jame Vincent, Jean-Luc Vachiéry, Thierry Bové, Guido Van Nooten

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Free light chains: potential biomarker and predictor of mortality in alpha-1-antitrypsin deficiency and usual COPD

Judith A. Hampson, Robert A. Stockley, Alice M. Turner

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

β-Glucan exacerbates allergic airway responses to house dust mite allergen

Sabelo Hadebe, Frank Kirstein, Kaat Fierens, Pierre Redelinghuys, Graeme I. Murray, David L. Williams, Bart N. Lambrecht, Frank Brombacher, Gordon D. Brown

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study

Olivia Freynet, Joëlle Marchal-Sommé, Francette Jean-Louis, Arnaud Mailleux, Bruno Crestani, Paul Soler, Laurence Michel

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Randomised trial of once-daily vilanterol in children with asthma on inhaled corticosteroid therapy

Amanda J. Oliver, Ronina A. Covar, Caroline H. Goldfrad, Ryan M. Klein, Søren E. Pedersen, Christine A. Sorkness, Susan A. Tomkins, César Villarán, Jonathan Grigg

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Innovations in health information technologies for chronic pulmonary diseases

Blanca E. Himes, Elissa R. Weitzman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis

Keishi Oda, Kazuhiro Yatera, Hiroto Izumi, Hiroshi Ishimoto, Sohsuke Yamada, Hiroyuki Nakao, Tetsuya Hanaka, Takaaki Ogoshi, Shingo Noguchi, Hiroshi Mukae

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The association of lung function and St. George's respiratory questionnaire with exacerbations in COPD: a systematic literature review and regression analysis

Amber L. Martin, Jessica Marvel, Kyle Fahrbach, Sarah M. Cadarette, Teresa K. Wilcox, James F. Donohue

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Expression of toll-like receptors 2 and 4 in subjects with asthma by total serum IgE level

Astrid Crespo-Lessmann, Eder Mateus, Silvia Vidal, David Ramos-Barbón, Montserrat Torrejón, Jordi Giner, Lorena Soto, Cándido Juárez, Vicente Plaza

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Gene-expression profiles in lung adenocarcinomas related to chronic wood smoke or tobacco exposure

Alette Ortega-Gómez, Claudia Rangel-Escareño, Camilo Molina-Romero, Eleazar Omar Macedo-Pérez, Alejandro Avilés-Salas, Alejandra Lara-García, Gerardo Alanis-Funes, Rubén Rodríguez-Bautista, Alfredo Hidalgo-Miranda, Oscar Arrieta

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study

P. E. Silkoff, M. Laviolette, D. Singh, J. M. FitzGerald, S. Kelsen, V. Backer, C. Porsbjerg, P. O. Girodet, P. Berger, J. N. Kline, S. Khatri, P. Chanez, V. S. Susulic, E. S. Barnathan, F. Baribaud, M. J. Loza, for the ADEPT Investigators

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Regeneration of the lung: Lung stem cells and the development of lung mimicking devices

Kim A. A. Schilders, Evelien Eenjes, Sander van Riet, André A. Poot, Dimitrios Stamatialis, Roman Truckenmüller, Pieter S. Hiemstra, Robbert J. Rottier

01.12.2016 | Research | Ausgabe 1/2016 Open Access

CD4+ and CD8+ T cells play a central role in a HDM driven model of allergic asthma

Kristof Raemdonck, Katie Baker, Nicole Dale, Eric Dubuis, Fisnik Shala, Maria G. Belvisi, Mark A. Birrell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Advanced glycation endproducts and their receptor in different body compartments in COPD

Susan J. M. Hoonhorst, Adèle T. Lo Tam Loi, Simon D. Pouwels, Alen Faiz, Eef D. Telenga, Maarten van den Berge, Leo Koenderman, Jan-Willem J. Lammers, H. Marike Boezen, Antoon J. M. van Oosterhout, Monique E. Lodewijk, Wim Timens, Dirkje S. Postma, Nick H. T. ten Hacken

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Identification of vitamin D sensitive pathways during lung development

Ling Chen, Richard Wilson, Ellen Bennett, Graeme R. Zosky

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Defining a COPD composite safety endpoint for demonstrating efficacy in clinical trials: results from the randomized, placebo-controlled UPLIFT® trial

Bartolomé R. Celli, Marc Decramer, Dacheng Liu, Norbert Metzdorf, Guus M. Asijee, Donald P. Tashkin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung

Monica Lucattelli, Silvia Fineschi, Enrico Selvi, Estrella Garcia Gonzalez, Barbara Bartalesi, Giovanna De Cunto, Sauro Lorenzini, Mauro Galeazzi, Giuseppe Lungarella

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown

Shuyan Xu, Xindong Xue, Kai You, Jianhua Fu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Fulvio Braido, Guy Brusselle, Daniele Guastalla, Eleonora Ingrassia, Gabriele Nicolini, David Price, Nicolas Roche, Joan B. Soriano, Heinrich Worth, on behalf of the LIAISON Study Group

01.12.2016 | Editorial | Ausgabe 1/2016 Open Access

The up-rise in e-cigarette use – friend or foe?

Bo Lundbäck, Paraskevi Katsaounou, Jan Lötvall

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Ethical considerations of e-cigarette use for tobacco harm reduction

Caroline Franck, Kristian B. Filion, Jonathan Kimmelman, Roland Grad, Mark J. Eisenberg

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study

Wen-Xiang Gao, Chun-Quan Ou, Shu-Bin Fang, Yue-Qi Sun, Hua Zhang, Lei Cheng, Yan-Jun Wang, Dong-Dong Zhu, Wei Lv, Shi-Xi Liu, P. Z. Li, Geng Xu, Jianbo Shi, Qing-Ling Fu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Electronic cigarettes: a survey of perceived patient use and attitudes among members of the British thoracic oncology group

Frances C. Sherratt, Lisa Newson, John K. Field

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Electronic cigarette exposure triggers neutrophil inflammatory responses

Andrew Higham, Nicholas J. W. Rattray, Jennifer A. Dewhurst, Drupad K. Trivedi, Stephen J. Fowler, Royston Goodacre, Dave Singh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine

Cara L. Sherwood, Scott Boitano

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Knowledge about electronic cigarettes and its perception: a community survey, Egypt

Omaima I. Abo-Elkheir, Eman Sobh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Microvascular reactivity is altered early in patients with acute respiratory distress syndrome

Diego Orbegozo Cortés, Lokmane Rahmania, Marian Irazabal, Carlos Santacruz, Vito Fontana, Daniel De Backer, Jacques Creteur, Jean-Louis Vincent

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Toxic and adjuvant effects of silica nanoparticles on ovalbumin-induced allergic airway inflammation in mice

Heejae Han, Yoon Hee Park, Hye Jung Park, Kangtaek Lee, Kiju Um, Jung-Won Park, Jae-Hyun Lee

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The effect of aclidinium bromide on daily respiratory symptoms of COPD, measured using the Evaluating Respiratory Symptoms in COPD (E-RS: COPD) diary: pooled analysis of two 6-month Phase III studies

Paul W. Jones, Nancy K. Leidy, Asha Hareendran, Rosa Lamarca, Ferran Chuecos, Esther Garcia Gil

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways

Amy Y. Chang, Tracy S. Mann, Peter K. McFawn, Liang Han, Xinzhong Dong, Peter J. Henry

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Therapeutic effect of budesonide/formoterol, montelukast and N-acetylcysteine for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation

Sei Won Kim, Chin Kook Rhee, Yoo Jin Kim, Seok Lee, Hee Je Kim, Jong Wook Lee

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A rapid NGS strategy for comprehensive molecular diagnosis of Birt-Hogg-Dubé syndrome in patients with primary spontaneous pneumothorax

Xinxin Zhang, Dehua Ma, Wei Zou, Yibing Ding, Chengchu Zhu, Haiyan Min, Bin Zhang, Wei Wang, Baofu Chen, Minhua Ye, Minghui Cai, Yanqing Pan, Lei Cao, Yueming Wan, Yu Jin, Qian Gao, Long Yi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The role of tissue factor and autophagy in pulmonary vascular remodeling in a rat model for chronic thromboembolic pulmonary hypertension

Chaosheng Deng, Dawen Wu, Minxia Yang, Yunfei Chen, Haibo Ding, Zhanghua Zhong, Ningfang Lian, Qiaoxian Zhang, Shuang Wu, Kaixiong Liu

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Surfactant proteins, SP-A and SP-D, in respiratory fungal infections: their role in the inflammatory response

Laura Elena Carreto-Binaghi, El Moukhtar Aliouat, Maria Lucia Taylor

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Role of the ion channel, transient receptor potential cation channel subfamily V member 1 (TRPV1), in allergic asthma

Katie Baker, Kristof Raemdonck, Bilel Dekkak, Robert J. Snelgrove, John Ford, Fisnik Shala, Maria G. Belvisi, Mark A. Birrell

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Exposure to common respiratory bacteria alters the airway epithelial response to subsequent viral infection

Carla Bellinghausen, Fahad Gulraiz, Alexandra C. A. Heinzmann, Mieke A. Dentener, Paul H. M. Savelkoul, Emiel F. Wouters, Gernot G. Rohde, Frank R. Stassen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients

Carl Hamsten, Emil Wiklundh, Hans Grönlund, Jochen M. Schwenk, Mathias Uhlén, Anders Eklund, Peter Nilsson, Johan Grunewald, Anna Häggmark-Månberg

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pharmacological characterisation of the interaction between glycopyrronium bromide and indacaterol fumarate in human isolated bronchi, small airways and bronchial epithelial cells

Mario Cazzola, Luigino Calzetta, Ermanno Puxeddu, Josuel Ora, Francesco Facciolo, Paola Rogliani, Maria Gabriella Matera

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection

Pedro Ayala, Manuel Meneses, Pablo Olmos, Rebeca Montalva, Karla Droguett, Mariana Ríos, Gisella Borzone

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Development of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT®) questionnaire: a new patient-reported outcome instrument for PAH

Deborah McCollister, Shannon Shaffer, David B. Badesch, Arthur Filusch, Elke Hunsche, René Schüler, Ingela Wiklund, Andrew Peacock

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Effects of tiotropium + olodaterol versus tiotropium or placebo by COPD disease severity and previous treatment history in the OTEMTO® studies

Dave Singh, Mina Gaga, Olaf Schmidt, Leif Bjermer, Lars Grönke, Florian Voß, Gary T. Ferguson

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Diagnostic value of plasma and bronchoalveolar lavage samples in acute lung allograft rejection: differential cytology

Nicole E. Speck, Macé M. Schuurmans, Christian Murer, Christian Benden, Lars C. Huber

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Inflammation and emphysema in cigarette smoke-exposed mice when instilled with poly (I:C) or infected with influenza A or respiratory syncytial viruses

Yohannes A. Mebratu, Kevin R. Smith, Getahun E. Agga, Yohannes Tesfaigzi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Tissue turnover of collagen type I, III and elastin is elevated in the PCLS model of IPF and can be restored back to vehicle levels using a phosphodiesterase inhibitor

Niels Ulrik Brandt Hansen, Morten Asser Karsdal, Sarah Brockbank, Simon Cruwys, Sarah Rønnow, Diana Julie Leeming

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Evaluation of the effects of olodaterol on exercise endurance in patients with chronic obstructive pulmonary disease: results from two 6-week crossover studies

François Maltais, Anne-Marie Kirsten, Alan Hamilton, Dorothy De Sousa, Florian Voß, Marc Decramer

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Micron-sized and submicron-sized aerosol deposition in a new ex vivo preclinical model

Sophie Perinel, Lara Leclerc, Nathalie Prévôt, Agathe Deville, Michèle Cottier, Marc Durand, Jean-Michel Vergnon, Jérémie Pourchez

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis

Tomoyuki Kakugawa, Noriho Sakamoto, Shuntaro Sato, Hirokazu Yura, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Yuji Ishimatsu, Yasushi Obase, Shigeru Kohno, Hiroshi Mukae

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Risk factors for mortality in patients admitted to intensive care units with pneumonia

Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Lauzier Francois, Andreas P. Freitag, Mitchell A. H. Levine, the PROTECT Investigators for the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Relative impact of COPD and comorbidities on generic health-related quality of life: a pooled analysis of the COSYCONET patient cohort and control subjects from the KORA and SHIP studies

Margarethe E. Wacker, Rudolf A. Jörres, Annika Karch, Armin Koch, Joachim Heinrich, Stefan Karrasch, Holger Schulz, Annette Peters, Sven Gläser, Ralf Ewert, Sebastian E. Baumeister, Claus Vogelmeier, Reiner Leidl, Rolf Holle, for the COSYCONET study group

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Weakly acidic pH reduces inflammatory cytokine expression in airway epithelial cells

A. P. Hackett, R. E. Trinick, K. Rose, B. F. Flanagan, P. S. McNamara

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Detection and quantification of epithelial progenitor cell populations in human healthy and IPF lungs

N. F. Smirnova, A. C. Schamberger, S. Nayakanti, R. Hatz, J. Behr, O. Eickelberg

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD

Fay Hollins, Amanda Sutcliffe, Edith Gomez, Rachid Berair, Richard Russell, Cédric Szyndralewiez, Ruth Saunders, Christopher Brightling

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats

Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G. Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren, Alan Hodgson, Jicheng Gong, Mary P. Ryan, Junfeng (Jim) Zhang, Alexandra Porter, Terry D. Tetley, Andrew Gow, Rachel Smith, Kian Fan Chung

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome

John Zagorski, Jeffrey A. Kline

01.12.2016 | Editorial | Ausgabe 1/2016 Open Access

An imperfect “PAST” Lessons learned from the National Review of Asthma Deaths (NRAD) UK

Shuaib Nasser

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Novel biomarkers for pulmonary arterial hypertension

Anjum Anwar, Gregoire Ruffenach, Aman Mahajan, Mansoureh Eghbali, Soban Umar

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation

Charity G. Duran, Allison J. Burbank, Katherine H. Mills, Heather R. Duckworth, Maria M. Aleman, Matthew J. Kesic, David B. Peden, Yinghao Pan, Haibo Zhou, Michelle L. Hernandez

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A phase II trial evaluating the efficacy and safety of perioperative pirfenidone for prevention of acute exacerbation of idiopathic pulmonary fibrosis in lung cancer patients undergoing pulmonary resection: West Japan Oncology Group 6711 L (PEOPLE Study)

Takekazu Iwata, Ichiro Yoshino, Shigetoshi Yoshida, Norihiko Ikeda, Masahiro Tsuboi, Yuji Asato, Nobuyuki Katakami, Kazuhiro Sakamoto, Yoshinori Yamashita, Jiro Okami, Tetsuya Mitsudomi, Motohiro Yamashita, Hiroshi Yokouchi, Kenichi Okubo, Morihito Okada, Mitsuhiro Takenoyama, Masayuki Chida, Keisuke Tomii, Motoki Matsuura, Arata Azuma, Tae Iwasawa, Kazuyoshi Kuwano, Shuji Sakai, Kenzo Hiroshima, Junya Fukuoka, Kenichi Yoshimura, Hirohito Tada, Kazuhiko Nakagawa, Yoichi Nakanishi, West Japan Oncology Group

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Vimentin dephosphorylation at ser-56 is regulated by type 1 protein phosphatase in smooth muscle

Jia Li, Ruping Wang, Dale D. Tang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases

Kristoffer Ostridge, Nicholas Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Ngaire A. Coombs, Paul T. Elkington, Raul San Jose Estepar, George Washko, Karl J. Staples, Tom M. A. Wilkinson

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells

Sina A. Gharib, Anagha Malur, Isham Huizar, Barbara P. Barna, Mani S. Kavuru, Lynn M. Schnapp, Mary Jane Thomassen

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response

Olivier Le Rouzic, Bachirou Koné, Jerome Kluza, Philippe Marchetti, Florence Hennegrave, Cécile Olivier, Gwenola Kervoaze, Eva Vilain, Clémence Mordacq, Nicolas Just, Thierry Perez, Nathalie Bautin, Muriel Pichavant, Philippe Gosset

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development

S. Miller, E. Melén, S. K. Merid, I. P. Hall, I. Sayers

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The role of circulating thrombospondin-1 in patients with precapillary pulmonary hypertension

Ralf Kaiser, Christian Frantz, Robert Bals, Heinrike Wilkens

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke

Danya Thayaparan, Pamela Shen, Martin R. Stämpfli, Mathieu C. Morissette

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Cardiovascular autonomic alterations in hospitalized patients with community-acquired pneumonia

Stefano Aliberti, Eleonora Tobaldini, Fabio Giuliani, Vanessa Nunziata, Giovanni Casazza, Giulia Suigo, Alice D’Adda, Giulia Bonaiti, Andrea Roveda, Andreia Queiroz, Valter Monzani, Alberto Pesci, Francesco Blasi, Nicola Montano

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Lung-specific RNA interference of coupling factor 6, a novel peptide, attenuates pulmonary arterial hypertension in rats

Jie Yin, Shuling You, Nannan Li, Shouhai Jiao, Hesheng Hu, Mei Xue, Ye Wang, Wenjuan Cheng, Ju Liu, Min Xu, Suhua Yan, Xiaolu Li

01.12.2016 | Research | Ausgabe 1/2016 Open Access

High resolution metabolomics to discriminate compounds in serum of male lung cancer patients in South Korea

Aryo D. Pamungkas, Changyoung Park, Sungyong Lee, Sun Ha Jee, Youngja H. Park

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pseudomonas aeruginosa colonization enhances ventilator-associated pneumonia-induced lung injury

Tzyy-Bin Tsay, Yu-Zhen Jiang, Ching-Mei Hsu, Lee-Wei Chen

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

How to achieve safe, high-quality clinical studies with non-Medicinal Investigational Products? A practical guideline by using intra-bronchial carbon nanoparticles as case study

M. Berger, P. J. Kooyman, M. Makkee, J. S. van der Zee, P. J. Sterk, J. van Dijk, E. M. Kemper

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis

Yan Xie, Haihong Jiang, Qian Zhang, Suneet Mehrotra, Peter W. Abel, Myron L. Toews, Dennis W. Wolff, Stephen Rennard, Reynold A. Panettieri Jr., Thomas B. Casale, Yaping Tu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Simvastatin up-regulates adenosine deaminase and suppresses osteopontin expression in COPD patients through an IL-13-dependent mechanism

Kittipong Maneechotesuwan, Kanda Kasetsinsombat, Adisak Wongkajornsilp, Peter J. Barnes

01.12.2016 | Research | Ausgabe 1/2016 Open Access

ALK gene copy number gains in non-small-cell lung cancer: prognostic impact and clinico-pathological correlations

U. Peretti, R. Ferrara, S. Pilotto, S. Kinspergher, M. Caccese, A. Santo, M. Brunelli, A. Caliò, L. Carbognin, I. Sperduti, M. Garassino, M. Chilosi, A. Scarpa, G. Tortora, E. Bria

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The impact of comorbidities on productivity loss in asthma patients

Solmaz Ehteshami-Afshar, J. Mark FitzGerald, Christopher Carlsten, Hamid Tavakoli, Roxanne Rousseau, Wan Cheng Tan, J. Douglass Rolf, Mohsen Sadatsafavi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Metformin attenuates lung fibrosis development via NOX4 suppression

Nahoko Sato, Naoki Takasaka, Masahiro Yoshida, Kazuya Tsubouchi, Shunsuke Minagawa, Jun Araya, Nayuta Saito, Yu Fujita, Yusuke Kurita, Kenji Kobayashi, Saburo Ito, Hiromichi Hara, Tsukasa Kadota, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hirofumi Utsumi, Hiroshi Wakui, Jun Kojima, Takanori Numata, Yumi Kaneko, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Hirotsugu Kohrogi, Kazuyoshi Kuwano

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension

Andrzej Fedorowicz, Łukasz Mateuszuk, Grzegorz Kopec, Tomasz Skórka, Barbara Kutryb-Zając, Agnieszka Zakrzewska, Maria Walczak, Andrzej Jakubowski, Magdalena Łomnicka, Ewa Słomińska, Stefan Chlopicki

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Dose-response to inhaled glycopyrrolate delivered with a novel Co-Suspension™ Delivery Technology metered dose inhaler (MDI) in patients with moderate-to-severe COPD

Leonardo M. Fabbri, Edward M. Kerwin, Selwyn Spangenthal, Gary T. Ferguson, Roberto Rodriguez-Roisin, James Pearle, Sanjay Sethi, Chad Orevillo, Patrick Darken, Earl St. Rose, Tracy Fischer, Michael Golden, Sarvajna Dwivedi, Colin Reisner

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Tomonori Makiguchi, Mitsuhiro Yamada, Yusuke Yoshioka, Hisatoshi Sugiura, Akira Koarai, Shigeki Chiba, Naoya Fujino, Yutaka Tojo, Chiharu Ota, Hiroshi Kubo, Seiichi Kobayashi, Masaru Yanai, Sanae Shimura, Takahiro Ochiya, Masakazu Ichinose

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

Wenxin Wu, Wei Zhang, J. Leland Booth, David C. Hutchings, Xiaoqiu Wang, Vicky L. White, Houssein Youness, Cory D. Cross, Ming-Hui Zou, Dennis Burian, Jordan P. Metcalf

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Pharmacological strategies to reduce exacerbation risk in COPD: a narrative review

Marc Miravitlles, Anthony D’Urzo, Dave Singh, Vladimir Koblizek

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: C-type natriuretic peptide ameliorates pulmonary fibrosis by acting on lung fibroblasts in mice

Toru Kimura, Takashi Nojiri, Jun Hino, Hiroshi Hosoda, Koichi Miura, Yasushi Shintani, Masayoshi Inoue, Masahiro Zenitani, Hiroyuki Takabatake, Mikiya Miyazato, Meinoshin Okumura, Kenji Kangawa

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells

Shan-shan Meng, Rong Gao, Bing-di Yan, Jin Ren, Fei Wu, Peng Chen, Jie Zhang, Li-fang Wang, Yuan-ming Xiao, Jing Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux

Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Thórarinn Gislason, Christer Janson, Anna-Carin Olin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Vitamin D and allergic airway disease shape the murine lung microbiome in a sex-specific manner

Michael Roggenbuck, Denise Anderson, Kenneth Klingenberg Barfod, Martin Feelisch, Sian Geldenhuys, Søren J. Sørensen, Clare E. Weeden, Prue H. Hart, Shelley Gorman

01.12.2016 | Research | Ausgabe 1/2016 Open Access

A HuR/TGF-β1 feedback circuit regulates airway remodeling in airway smooth muscle cells

Na Wang, Di Yan, Yi Liu, Yao Liu, Xianmin Gu, Jian Sun, Fei Long, Shujuan Jiang

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis

Mariana Kasabova, Bérengère Villeret, Aurélie Gombault, Fabien Lecaille, Thomas Reinheckel, Sylvain Marchand-Adam, Isabelle Couillin, Gilles Lalmanach

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The genetic and epigenetic landscapes of the epithelium in asthma

Fatemeh Moheimani, Alan C-Y Hsu, Andrew T Reid, Teresa Williams, Anthony Kicic, Stephen M. Stick, Philip M. Hansbro, Peter A.B. Wark, Darryl A. Knight

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Eligibility of real-life patients with COPD for inclusion in trials of inhaled long-acting bronchodilator therapy

David M. G. Halpin, Marjan Kerkhof, Joan B. Soriano, Helga Mikkelsen, David B. Price

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Extracellular ATP is involved in dsRNA-induced MUC5AC production via P2Y2R in human airway epithelium

Yutaka Shishikura, Akira Koarai, Hiroyuki Aizawa, Mutsuo Yamaya, Hisatoshi Sugiura, Mika Watanabe, Yuichiro Hashimoto, Tadahisa Numakura, Tomonori Makiguti, Kyoko Abe, Mituhiro Yamada, Toshiaki Kikuchi, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Prevalence and risk factors for asthma among children aged 0–14 years in Hangzhou: a cross-sectional survey

Dan Xu, Yingshuo Wang, Zhimin Chen, Shuxian Li, Yungai Cheng, Li Zhang, Lingzhi Zhao

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Effects of inhaled high-molecular weight hyaluronan in inflammatory airway disease

Adelaida Lamas, Jamie Marshburn, Vandy P. Stober, Scott H. Donaldson, Stavros Garantziotis

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

Thomas Southworth, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis, Martin D. Lehner, Montserrat Miralpeix, Dave Singh

01.12.2016 | Research | Ausgabe 1/2016 Open Access

High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

Jannie M. B. Sand, Diana J. Leeming, Inger Byrjalsen, Asger R. Bihlet, Peter Lange, Ruth Tal-Singer, Bruce E. Miller, Morten A. Karsdal, Jørgen Vestbo

01.12.2016 | Letter to the Editor | Ausgabe 1/2016 Open Access

Periplakin is a target for autoimmunity in asthma

Camille Taillé, Sabine Grootenboer-Mignot, Candice Estellat, Carine Roy, Sophie Ly Ka So, Marina Pretolani, Michel Aubier, Bruno Crestani, Sylvie Chollet-Martin

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Basic science of electronic cigarettes: assessment in cell culture and in vivo models

Pieter S. Hiemstra, Robert Bals

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia

Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Francois Lauzier, Andreas P. Freitag, Mitchell A. H. Levine, the PROTECT Investigators for the Canadian Critical Care Trials Group, the Australian and New Zealand Intensive Care Society Clinical Trials Group

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

Rachel Boxio, Julien Wartelle, Béatrice Nawrocki-Raby, Brice Lagrange, Laurette Malleret, Timothee Hirche, Clifford Taggart, Yves Pacheco, Gilles Devouassoux, Abderrazzaq Bentaher

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Respiratory symptoms, sleep-disordered breathing and biomarkers in nocturnal gastroesophageal reflux

Össur Ingi Emilsson, Bryndís Benediktsdóttir, Ísleifur Ólafsson, Elizabeth Cook, Sigurður Júlíusson, Einar Stefán Björnsson, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, Ekaterina Mirgorodskaya, Evert Ljungström, Erna Sif Arnardóttir, Þórarinn Gíslason, Christer Janson, Anna-Carin Olin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Predicting survival of patients with idiopathic pulmonary fibrosis using GAP score: a nationwide cohort study

Sang Hoon Lee, Song Yee Kim, Dong Soon Kim, Young Whan Kim, Man Pyo Chung, Soo Taek Uh, Choon Sik Park, Sung Hwan Jeong, Yong Bum Park, Hong Lyeol Lee, Jong Wook Shin, Eun Joo Lee, Jin Hwa Lee, Yangin Jegal, Hyun Kyung Lee, Yong Hyun Kim, Jin Woo Song, Sung Woo Park, Moo Suk Park

01.12.2016 | Research | Ausgabe 1/2016 Open Access

T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways

Hitendra S. Chand, Yohannes A. Mebratu, Marena Montera, Yohannes Tesfaigzi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium

Leslie A. Blair, April K. Haven, Natalie N. Bauer

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells

Shan-shan Meng, Rong Gao, Bing-di Yan, Jin Ren, Fei Wu, Peng Chen, Jie Zhang, Li-fang Wang, Yuan-ming Xiao, Jing Liu

01.12.2016 | Research | Ausgabe 1/2016 Open Access

N-methyl-D-aspartate receptor activation mediates lung fibroblast proliferation and differentiation in hyperoxia-induced chronic lung disease in newborn rats

YanRui Wang, ShaoJie Yue, ZiQiang Luo, ChuanDing Cao, XiaoHe Yu, ZhengChang Liao, MingJie Wang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Steroid resistance in COPD is associated with impaired molecular chaperone Hsp90 expression by pro-inflammatory lymphocytes

Greg Hodge, Eugene Roscioli, Hubertus Jersmann, Hai B. Tran, Mark Holmes, Paul N. Reynolds, Sandra Hodge

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Proteases and oxidant stress control organic dust induction of inflammatory gene expression in lung epithelial cells

Kartiga Natarajan, Koteswara R. Gottipati, Kiflu Berhane, Buka Samten, Usha Pendurthi, Vijay Boggaram

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Lung function reductions associated with motor vehicle density in chronic obstructive pulmonary disease: a cross-sectional study

Monika Nitschke, Sarah L. Appleton, Qiaoyu Li, Graeme R. Tucker, Pushan Shah, Peng Bi, Dino L. Pisaniello, Robert J. Adams

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease

Ryo Kato, Shiro Mizuno, Maiko Kadowaki, Kohei Shiozaki, Masaya Akai, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Norbert F Voelkel, Hirohisa Toga

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Differences in systemic adaptive immunity contribute to the ‘frequent exacerbator’ COPD phenotype

Jasper X. Geerdink, Sami O. Simons, Rebecca Pike, Hans J. Stauss, Yvonne F. Heijdra, John R. Hurst

01.12.2016 | Research | Ausgabe 1/2016 Open Access

EIF2AK4 mutation as “second hit” in hereditary pulmonary arterial hypertension

Christina A. Eichstaedt, Jie Song, Nicola Benjamin, Satenik Harutyunova, Christine Fischer, Ekkehard Grünig, Katrin Hinderhofer

01.12.2016 | Erratum | Ausgabe 1/2016 Open Access

Erratum to: Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

Pil-Sung Yang, Dae-Hoon Kim, Yong Joon Lee, Sang-Eun Lee, Won Jun Kang, Hyuk-Jae Chang, Jeon-Soo Shin

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations

Robert Busch, Weiliang Qiu, Jessica Lasky-Su, Jarrett Morrow, Gerard Criner, Dawn DeMeo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Increased AGE-RAGE ratio in idiopathic pulmonary fibrosis

Carlos Machahua, Ana Montes-Worboys, Roger Llatjos, Ignacio Escobar, Jordi Dorca, Maria Molina-Molina, Vanesa Vicens-Zygmunt

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Non-neuronal cholinergic system contributes to corticosteroid resistance in chronic obstructive pulmonary disease patients

Javier Milara, Angela Cervera, Alfredo de Diego, Celia Sanz, Gustavo Juan, Amadeu Gavaldà, Montserrat Miralpeix, Esteban Morcillo, Julio Cortijo

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells

Tomomi Terashita, Kazuyuki Kobayashi, Tatsuya Nagano, Yoshitaka Kawa, Daisuke Tamura, Kyosuke Nakata, Masatsugu Yamamoto, Motoko Tachihara, Hiroshi Kamiryo, Yoshihiro Nishimura

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Spirometric variability in smokers: transitions in COPD diagnosis in a five-year longitudinal study

Akshay Sood, Hans Petersen, Clifford Qualls, Paula M. Meek, Rodrigo Vazquez-Guillamet, Bartolome R. Celli, Yohannes Tesfaigzi

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Disharmony between wake- and respiration-promoting activities: effects of modafinil on ventilatory control in rodents

Jiro Terada, Isato Fukushi, Kotaro Takeda, Yohei Hasebe, Mieczyslaw Pokorski, Koichiro Tatsumi, Yasumasa Okada

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Rising total costs and mortality rates associated with admissions due to COPD exacerbations

Nicolas Molinari, Pascal Chanez, Nicolas Roche, Engi Ahmed, Isabelle Vachier, Arnaud Bourdin

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review

Elisabetta Zinellu, Angelo Zinellu, Alessandro Giuseppe Fois, Ciriaco Carru, Pietro Pirina

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness

Morgan Le Guen, Stanislas Grassin-Delyle, Emmanuel Naline, Amparo Buenestado, Marion Brollo, Elisabeth Longchampt, Philippe Kleinmann, Philippe Devillier, Christophe Faisy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Evaluation of the use of Swedish integrated electronic health records and register health care data as support clinical trials in severe asthma: the PACEHR study

Stefan Franzén, Christer Janson, Kjell Larsson, Max Petzold, Urban Olsson, Gunnar Magnusson, Gunilla Telg, Gene Colice, Gunnar Johansson, Mats Sundgren

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Impaired anti-inflammatory action of glucocorticoid in neutrophil from patients with steroid-resistant asthma

Meijia Wang, Pengfei Gao, Xiaojie Wu, Yuetao Chen, Yikuan Feng, Qun Yang, Yongjian Xu, Jianping Zhao, Jungang Xie

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Diagnostic accuracy of methacholine challenge tests assessing airway hyperreactivity in asthmatic patients - a multifunctional approach

Richard Kraemer, Hans-Jürgen Smith, Thomas Sigrist, Gabi Giger, Roland Keller, Martin Frey

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pulmonary endothelial activation caused by extracellular histones contributes to neutrophil activation in acute respiratory distress syndrome

Yanlin Zhang, Li Guan, Jie Yu, Zanmei Zhao, Lijun Mao, Shuqiang Li, Jinyuan Zhao

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Respiratory viral infections and host responses; insights from genomics

Niamh M. Troy, Anthony Bosco

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma

Paul M. O’Byrne, Loretta Jacques, Caroline Goldfrad, Namhee Kwon, Michael Perrio, Louisa J. Yates, William W. Busse

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Variable ventilation improves pulmonary function and reduces lung damage without increasing bacterial translocation in a rat model of experimental pneumonia

Raquel F. de Magalhães, Cynthia S. Samary, Raquel S. Santos, Milena V. de Oliveira, Nazareth N. Rocha, Cintia L. Santos, Jamil Kitoko, Carlos A. M. Silva, Caroline L. Hildebrandt, Cassiano F. Goncalves-de-Albuquerque, Adriana R. Silva, Hugo C. Faria-Neto, Vanessa Martins, Vera L. Capelozzi, Robert Huhle, Marcelo M. Morales, Priscilla Olsen, Paolo Pelosi, Marcelo Gama de Abreu, Patricia R. M. Rocco, Pedro L. Silva

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Increased expression of TROP2 in airway basal cells potentially contributes to airway remodeling in chronic obstructive pulmonary disease

Qixiao Liu, Haijun Li, Qin Wang, Yuke Zhang, Wei Wang, Shuang Dou, Wei Xiao

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pulmonary hypertension and vascular remodeling in mice exposed to crystalline silica

Igor N. Zelko, Jianxin Zhu, Jeffrey D. Ritzenthaler, Jesse Roman

01.12.2016 | Review | Ausgabe 1/2016 Open Access

Lung bioengineering: physical stimuli and stem/progenitor cell biology interplay towards biofabricating a functional organ

Paula N. Nonaka, Juan J. Uriarte, Noelia Campillo, Vinicius R. Oliveira, Daniel Navajas, Ramon Farré

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Pleural inhibition of the caspase-1/IL-1β pathway diminishes profibrotic lung toxicity of bleomycin

Olivier Burgy, Pierre-Simon Bellaye, Sebastien Causse, Guillaume Beltramo, Guillaume Wettstein, Pierre-Marie Boutanquoi, Françoise Goirand, Carmen Garrido, Philippe Bonniaud

01.12.2016 | Review | Ausgabe 1/2016 Open Access

The Microbiome and the Pathophysiology of Asthma

Ashley Sullivan, Eoin Hunt, John MacSharry, Desmond M. Murphy

01.12.2016 | Research | Ausgabe 1/2016 Open Access

The cellular kinetics of lung alveolar epithelial cells and its relationship with lung tissue repair after acute lung injury

Ling Zeng, Xue-tao Yang, Hai-sheng Li, Yong Li, Ce Yang, Wei Gu, Yin-han Zhou, Juan Du, Hai-yan Wang, Jian-hui Sun, Da-lin Wen, Jian-xin Jiang

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study

Matthew J. Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S. Barnathan, Vedrana S. Susulic, Philip E. Silkoff, Peter J. Sterk, Frédéric Baribaud, For the ADEPT (Airways Disease Endotyping for Personalized Therapeutics) and U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome Consortium) investigators

01.12.2016 | Research | Ausgabe 1/2016 Open Access

Evidence for harm reduction in COPD smokers who switch to electronic cigarettes

Riccardo Polosa, Jaymin Bhagwanji Morjaria, Pasquale Caponnetto, Umberto Prosperini, Cristina Russo, Alfio Pennisi, Cosimo Marcello Bruno

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