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Erschienen in: Journal of Gastrointestinal Surgery 1/2018

14.08.2017 | SSAT State-of-the-Art Conference

SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors

verfasst von: Jeffrey A. Norton, Teresa Kim, Joseph Kim, Martin D. McCarter, Kaitlyn J. Kelly, Joyce Wong, Jason K. Sicklick

Erschienen in: Journal of Gastrointestinal Surgery | Ausgabe 1/2018

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Abstract

Introduction

The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies.

Methods

In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery.

Results

Martin D. McCarter, MD of the University of Colorado discussed the current management of gastric gastrointestinal stromal tumors (GIST). Kaitlyn J. Kelly, MD of the University of California, San Diego discussed the management of gastric carcinoid tumors. Jeffrey A. Norton of Stanford University discussed recent advances in the management of gastric adenocarcinoma including a focus on hereditary diffuse gastric cancer (HDGC). Joseph Kim, MD of Stony Brook University discussed a systematic approach to minimally invasive gastrectomy for cancer. Joyce Wong, MD of Pennsylvania State University discussed the role for cytoreductive surgery (CRS) and HIPEC for gastric adenocarcinoma.

Conclusions

This review provides gastrointestinal surgeons with a concise update on the current surgical management of gastric tumors.
Literatur
3.
4.
Zurück zum Zitat DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Annals of surgery. 2000;231(1):51–8.CrossRefPubMedPubMedCentral DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Annals of surgery. 2000;231(1):51–8.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Archives of Pathology & Laboratory Medicine. 2006;130(10):1466–78. Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Archives of Pathology & Laboratory Medicine. 2006;130(10):1466–78.
7.
Zurück zum Zitat Fero KE, Coe TM, Fanta PT, Tang CM, Murphy JD, Sicklick JK. Surgical management of adolescents and young adults with gastrointestinal stromal tumors: a US population-based analysis. JAMA Surgery. 2017. doi:10.1001/jamasurg.2016.5047. Fero KE, Coe TM, Fanta PT, Tang CM, Murphy JD, Sicklick JK. Surgical management of adolescents and young adults with gastrointestinal stromal tumors: a US population-based analysis. JAMA Surgery. 2017. doi:10.​1001/​jamasurg.​2016.​5047.
8.
Zurück zum Zitat Gold JS, Gonen M, Gutierrez A, Broto JM, Garcia-del-Muro X, Smyrk TC et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. The Lancet Oncology. 2009;10(11):1045–52. doi:10.1016/S1470-2045(09)70242-6.CrossRefPubMedPubMedCentral Gold JS, Gonen M, Gutierrez A, Broto JM, Garcia-del-Muro X, Smyrk TC et al. Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: a retrospective analysis. The Lancet Oncology. 2009;10(11):1045–52. doi:10.​1016/​S1470-2045(09)70242-6.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen SE, Brabec P et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. The Lancet Oncology. 2012;13(3):265–74. doi:10.1016/S1470-2045(11)70299-6.CrossRefPubMed Joensuu H, Vehtari A, Riihimaki J, Nishida T, Steigen SE, Brabec P et al. Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts. The Lancet Oncology. 2012;13(3):265–74. doi:10.​1016/​S1470-2045(11)70299-6.CrossRefPubMed
10.
Zurück zum Zitat Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L et al. KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2015;33(6):634–42. doi:10.1200/JCO.2014.57.4970.CrossRef Joensuu H, Rutkowski P, Nishida T, Steigen SE, Brabec P, Plank L et al. KIT and PDGFRA mutations and the risk of GI stromal tumor recurrence. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2015;33(6):634–42. doi:10.​1200/​JCO.​2014.​57.​4970.CrossRef
11.
Zurück zum Zitat Sicklick JK, Lopez NE. Optimizing surgical and imatinib therapy for the treatment of gastrointestinal stromal tumors. Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract. 2013;17(11):1997–2006. doi:10.1007/s11605-013-2243-0.CrossRef Sicklick JK, Lopez NE. Optimizing surgical and imatinib therapy for the treatment of gastrointestinal stromal tumors. Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract. 2013;17(11):1997–2006. doi:10.​1007/​s11605-013-2243-0.CrossRef
12.
Zurück zum Zitat Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. The New England Journal of Medicine. 2001;344(14):1052–6. doi:10.1056/NEJM200104053441404.CrossRefPubMed Joensuu H, Roberts PJ, Sarlomo-Rikala M, Andersson LC, Tervahartiala P, Tuveson D et al. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor. The New England Journal of Medicine. 2001;344(14):1052–6. doi:10.​1056/​NEJM200104053441​404.CrossRefPubMed
13.
14.
Zurück zum Zitat Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schutte J et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA : the Journal of the American Medical Association. 2012;307(12):1265–72. doi:10.1001/jama.2012.347.CrossRefPubMed Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Schutte J et al. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA : the Journal of the American Medical Association. 2012;307(12):1265–72. doi:10.​1001/​jama.​2012.​347.CrossRefPubMed
15.
Zurück zum Zitat Fraenkel M, Kim M, Faggiano A, de Herder WW, Valk GD, Knowledge N. Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature. Endocr Relat Cancer. 2014;21(3):R153–63. doi:10.1530/ERC-13-0125.CrossRefPubMed Fraenkel M, Kim M, Faggiano A, de Herder WW, Valk GD, Knowledge N. Incidence of gastroenteropancreatic neuroendocrine tumours: a systematic review of the literature. Endocr Relat Cancer. 2014;21(3):R153–63. doi:10.​1530/​ERC-13-0125.CrossRefPubMed
16.
17.
Zurück zum Zitat Fendrich V, Bartsch DK. Surgical treatment of gastrointestinal neuroendocrine tumors. Langenbeck’s Archives of Surgery/Deutsche Gesellschaft fur Chirurgie. 2011;396(3):299–311. doi:10.1007/s00423-011-0741-7.CrossRef Fendrich V, Bartsch DK. Surgical treatment of gastrointestinal neuroendocrine tumors. Langenbeck’s Archives of Surgery/Deutsche Gesellschaft fur Chirurgie. 2011;396(3):299–311. doi:10.​1007/​s00423-011-0741-7.CrossRef
21.
Zurück zum Zitat Postlewait LM, Baptiste GG, Ethun CG, Le N, Cardona K, Russell MC et al. A 15-year experience with gastric neuroendocrine tumors: does type make a difference? Journal of Surgical Oncology. 2016;114(5):576–80. doi:10.1002/jso.24369.CrossRefPubMed Postlewait LM, Baptiste GG, Ethun CG, Le N, Cardona K, Russell MC et al. A 15-year experience with gastric neuroendocrine tumors: does type make a difference? Journal of Surgical Oncology. 2016;114(5):576–80. doi:10.​1002/​jso.​24369.CrossRefPubMed
23.
Zurück zum Zitat Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B et al. Well-differentiated gastric tumors/carcinomas. Neuroendocrinology. 2006;84(3):158–64. doi:10.1159/000098007.CrossRefPubMed Ruszniewski P, Delle Fave G, Cadiot G, Komminoth P, Chung D, Kos-Kudla B et al. Well-differentiated gastric tumors/carcinomas. Neuroendocrinology. 2006;84(3):158–64. doi:10.​1159/​000098007.CrossRefPubMed
24.
Zurück zum Zitat Doherty GM, Olson JA, Frisella MM, Lairmore TC, Wells SA, Jr., Norton JA. Lethality of multiple endocrine neoplasia type I. World J Surg. 1998;22(6):581–6; discussion 6-7.CrossRefPubMed Doherty GM, Olson JA, Frisella MM, Lairmore TC, Wells SA, Jr., Norton JA. Lethality of multiple endocrine neoplasia type I. World J Surg. 1998;22(6):581–6; discussion 6-7.CrossRefPubMed
27.
Zurück zum Zitat Lesurtel M, Nagorney DM, Mazzaferro V, Jensen RT, Poston GJ. When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations. HPB (Oxford). 2015;17(1):17–22. doi:10.1111/hpb.12225.CrossRef Lesurtel M, Nagorney DM, Mazzaferro V, Jensen RT, Poston GJ. When should a liver resection be performed in patients with liver metastases from neuroendocrine tumours? A systematic review with practice recommendations. HPB (Oxford). 2015;17(1):17–22. doi:10.​1111/​hpb.​12225.CrossRef
29.
Zurück zum Zitat Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a Cancer Journal for Clinicians. 2015;65(2):87–108. doi:10.3322/caac.21262. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA: a Cancer Journal for Clinicians. 2015;65(2):87–108. doi:10.​3322/​caac.​21262.
30.
33.
34.
Zurück zum Zitat Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. The New England Journal of Medicine. 2006;355(1):11–20. doi:10.1056/NEJMoa055531.CrossRefPubMed Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. The New England Journal of Medicine. 2006;355(1):11–20. doi:10.​1056/​NEJMoa055531.CrossRefPubMed
35.
Zurück zum Zitat Ychou M, Boige V, Pignon JP, Conroy T, Bouche O, Lebreton G et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29(13):1715–21. doi:10.1200/JCO.2010.33.0597.CrossRef Ychou M, Boige V, Pignon JP, Conroy T, Bouche O, Lebreton G et al. Perioperative chemotherapy compared with surgery alone for resectable gastroesophageal adenocarcinoma: an FNCLCC and FFCD multicenter phase III trial. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29(13):1715–21. doi:10.​1200/​JCO.​2010.​33.​0597.CrossRef
36.
Zurück zum Zitat Al-Batran SE, Hofheinz RD, Pauligk C, Kopp HG, Haag GM, Luley KB et al. Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. The Lancet Oncology. 2016;17(12):1697–708. doi:10.1016/S1470-2045(16)30531-9.CrossRefPubMed Al-Batran SE, Hofheinz RD, Pauligk C, Kopp HG, Haag GM, Luley KB et al. Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. The Lancet Oncology. 2016;17(12):1697–708. doi:10.​1016/​S1470-2045(16)30531-9.CrossRefPubMed
37.
Zurück zum Zitat Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29(33):4387–93. doi:10.1200/JCO.2011.36.5908.CrossRef Sasako M, Sakuramoto S, Katai H, Kinoshita T, Furukawa H, Yamaguchi T et al. Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29(33):4387–93. doi:10.​1200/​JCO.​2011.​36.​5908.CrossRef
38.
Zurück zum Zitat Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet. 2012;379(9813):315–21. doi:10.1016/S0140-6736(11)61873-4.CrossRefPubMed Bang YJ, Kim YW, Yang HK, Chung HC, Park YK, Lee KH et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet. 2012;379(9813):315–21. doi:10.​1016/​S0140-6736(11)61873-4.CrossRefPubMed
39.
Zurück zum Zitat Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–97. doi:10.1016/S0140-6736(10)61121-X.CrossRefPubMed Bang YJ, Van Cutsem E, Feyereislova A, Chung HC, Shen L, Sawaki A et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet. 2010;376(9742):687–97. doi:10.​1016/​S0140-6736(10)61121-X.CrossRefPubMed
41.
Zurück zum Zitat Hebbard PC, Macmillan A, Huntsman D, Kaurah P, Carneiro F, Wen X et al. Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. Annals of Surgical Oncology. 2009;16(7):1890–5. doi:10.1245/s10434-009-0471-z.CrossRefPubMed Hebbard PC, Macmillan A, Huntsman D, Kaurah P, Carneiro F, Wen X et al. Prophylactic total gastrectomy (PTG) for hereditary diffuse gastric cancer (HDGC): the Newfoundland experience with 23 patients. Annals of Surgical Oncology. 2009;16(7):1890–5. doi:10.​1245/​s10434-009-0471-z.CrossRefPubMed
42.
Zurück zum Zitat Chen Y, Kingham K, Ford JM, Rosing J, Van Dam J, Jeffrey RB et al. A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer. Annals of Surgical Oncology. 2011;18(9):2594–8. doi:10.1245/s10434-011-1648-9.CrossRefPubMed Chen Y, Kingham K, Ford JM, Rosing J, Van Dam J, Jeffrey RB et al. A prospective study of total gastrectomy for CDH1-positive hereditary diffuse gastric cancer. Annals of Surgical Oncology. 2011;18(9):2594–8. doi:10.​1245/​s10434-011-1648-9.CrossRefPubMed
43.
Zurück zum Zitat Bardram L, Hansen TV, Gerdes AM, Timshel S, Friis-Hansen L, Federspiel B. Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations-a clinical observational study. Familial Cancer. 2014;13(2):231–42. doi:10.1007/s10689-013-9698-8.CrossRefPubMed Bardram L, Hansen TV, Gerdes AM, Timshel S, Friis-Hansen L, Federspiel B. Prophylactic total gastrectomy in hereditary diffuse gastric cancer: identification of two novel CDH1 gene mutations-a clinical observational study. Familial Cancer. 2014;13(2):231–42. doi:10.​1007/​s10689-013-9698-8.CrossRefPubMed
44.
Zurück zum Zitat Worster E, Liu X, Richardson S, Hardwick RH, Dwerryhouse S, Caldas C et al. The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study. Annals of Surgery. 2014;260(1):87–93. doi:10.1097/SLA.0000000000000446.CrossRefPubMed Worster E, Liu X, Richardson S, Hardwick RH, Dwerryhouse S, Caldas C et al. The impact of prophylactic total gastrectomy on health-related quality of life: a prospective cohort study. Annals of Surgery. 2014;260(1):87–93. doi:10.​1097/​SLA.​0000000000000446​.CrossRefPubMed
45.
Zurück zum Zitat Benusiglio PR, Malka D, Rouleau E, De Pauw A, Buecher B, Nogues C et al. CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study. Journal of Medical Genetics. 2013;50(7):486–9. doi:10.1136/jmedgenet-2012-101472.CrossRefPubMed Benusiglio PR, Malka D, Rouleau E, De Pauw A, Buecher B, Nogues C et al. CDH1 germline mutations and the hereditary diffuse gastric and lobular breast cancer syndrome: a multicentre study. Journal of Medical Genetics. 2013;50(7):486–9. doi:10.​1136/​jmedgenet-2012-101472.CrossRefPubMed
47.
Zurück zum Zitat Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Annals of Surgery. 2005;241(2):232–7.CrossRefPubMedPubMedCentral Huscher CG, Mingoli A, Sgarzini G, Sansonetti A, Di Paola M, Recher A et al. Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: five-year results of a randomized prospective trial. Annals of Surgery. 2005;241(2):232–7.CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Vinuela EF, Gonen M, Brennan MF, Coit DG, Strong VE. Laparoscopic versus open distal gastrectomy for gastric cancer: a meta-analysis of randomized controlled trials and high-quality nonrandomized studies. Annals of Surgery. 2012;255(3):446–56. doi:10.1097/SLA.0b013e31824682f4.CrossRefPubMed Vinuela EF, Gonen M, Brennan MF, Coit DG, Strong VE. Laparoscopic versus open distal gastrectomy for gastric cancer: a meta-analysis of randomized controlled trials and high-quality nonrandomized studies. Annals of Surgery. 2012;255(3):446–56. doi:10.​1097/​SLA.​0b013e31824682f4​.CrossRefPubMed
50.
Zurück zum Zitat Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a Cancer Journal for Clinicians. 2011;61(2):69–90. doi:10.3322/caac.20107. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a Cancer Journal for Clinicians. 2011;61(2):69–90. doi:10.​3322/​caac.​20107.
51.
Zurück zum Zitat Hamner J, Kim J. Surgery for cancers of the gastrointestinal tract. New York, NY: Springer-Verlag; 2014. p. 75–86. Hamner J, Kim J. Surgery for cancers of the gastrointestinal tract. New York, NY: Springer-Verlag; 2014. p. 75–86.
52.
Zurück zum Zitat Koga S, Hamazoe R, Maeta M, Shimizu N, Murakami A, Wakatsuki T. Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C. Cancer. 1988;61(2):232–7.CrossRefPubMed Koga S, Hamazoe R, Maeta M, Shimizu N, Murakami A, Wakatsuki T. Prophylactic therapy for peritoneal recurrence of gastric cancer by continuous hyperthermic peritoneal perfusion with mitomycin C. Cancer. 1988;61(2):232–7.CrossRefPubMed
53.
Zurück zum Zitat Passot G, Vaudoyer D, Villeneuve L, Kepenekian V, Beaujard AC, Bakrin N et al. What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1125 procedures. Journal of Surgical Oncology 2016;113(7):796–803. doi:10.1002/jso.24248.CrossRefPubMed Passot G, Vaudoyer D, Villeneuve L, Kepenekian V, Beaujard AC, Bakrin N et al. What made hyperthermic intraperitoneal chemotherapy an effective curative treatment for peritoneal surface malignancy: A 25-year experience with 1125 procedures. Journal of Surgical Oncology 2016;113(7):796–803. doi:10.​1002/​jso.​24248.CrossRefPubMed
54.
Zurück zum Zitat Yang XJ, Huang CQ, Suo T, Mei LJ, Yang GL, Cheng FL et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Annals of Surgical Oncology. 2011;18(6):1575–81. doi:10.1245/s10434-011-1631-5.CrossRefPubMedPubMedCentral Yang XJ, Huang CQ, Suo T, Mei LJ, Yang GL, Cheng FL et al. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy improves survival of patients with peritoneal carcinomatosis from gastric cancer: final results of a phase III randomized clinical trial. Annals of Surgical Oncology. 2011;18(6):1575–81. doi:10.​1245/​s10434-011-1631-5.CrossRefPubMedPubMedCentral
55.
Zurück zum Zitat Rudloff U, Langan RC, Mullinax JE, Beane JD, Steinberg SM, Beresnev T et al. Impact of maximal cytoreductive surgery plus regional heated intraperitoneal chemotherapy (HIPEC) on outcome of patients with peritoneal carcinomatosis of gastric origin: results of the GYMSSA trial. Journal of Surgical Oncology. 2014;110(3):275–84. doi:10.1002/jso.23633.CrossRefPubMed Rudloff U, Langan RC, Mullinax JE, Beane JD, Steinberg SM, Beresnev T et al. Impact of maximal cytoreductive surgery plus regional heated intraperitoneal chemotherapy (HIPEC) on outcome of patients with peritoneal carcinomatosis of gastric origin: results of the GYMSSA trial. Journal of Surgical Oncology. 2014;110(3):275–84. doi:10.​1002/​jso.​23633.CrossRefPubMed
56.
Zurück zum Zitat Chia CS, You B, Decullier E, Vaudoyer D, Lorimier G, Abboud K et al. Patients with peritoneal carcinomatosis from gastric cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is cure a possibility? Annals of Surgical Oncology. 2016;23(6):1971–9. doi:10.1245/s10434-015-5081-3.CrossRefPubMed Chia CS, You B, Decullier E, Vaudoyer D, Lorimier G, Abboud K et al. Patients with peritoneal carcinomatosis from gastric cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is cure a possibility? Annals of Surgical Oncology. 2016;23(6):1971–9. doi:10.​1245/​s10434-015-5081-3.CrossRefPubMed
Metadaten
Titel
SSAT State-of-the-Art Conference: Current Surgical Management of Gastric Tumors
verfasst von
Jeffrey A. Norton
Teresa Kim
Joseph Kim
Martin D. McCarter
Kaitlyn J. Kelly
Joyce Wong
Jason K. Sicklick
Publikationsdatum
14.08.2017
Verlag
Springer US
Erschienen in
Journal of Gastrointestinal Surgery / Ausgabe 1/2018
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
DOI
https://doi.org/10.1007/s11605-017-3533-8

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