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Erschienen in: Basic Research in Cardiology 5/2010

01.09.2010 | Original Contribution

Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death

verfasst von: Alain Hirschy, Adrien Croquelois, Evelyne Perriard, Roman Schoenauer, Irina Agarkova, Simon P. Hoerstrup, Makoto M. Taketo, Thierry Pedrazzini, Jean-Claude Perriard, Elisabeth Ehler

Erschienen in: Basic Research in Cardiology | Ausgabe 5/2010

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Abstract

Beta-catenin is a component of the intercalated disc in cardiomyocytes, but can also be involved in signalling and activation of gene transcription. We wanted to determine how long-term changes in beta-catenin expression levels would affect mature cardiomyocytes. Conditional transgenic mice that either lacked beta-catenin or that expressed a non-degradable form of beta-catenin in the adult ventricle were created. While mice lacking beta-catenin in the ventricle do not have an overt phenotype, mice expressing a non-degradable form develop dilated cardiomyopathy and do not survive beyond 5 months. A detailed analysis could reveal that this phenotype is correlated with a distinct localisation of beta-catenin in adult cardiomyocytes, which cannot be detected in the nucleus, no matter how much protein is present. Our report is the first study that addresses long-term effects of either the absence of beta-catenin or its stabilisation on ventricular cardiomyocytes and it suggests that beta-catenin’s role in the nucleus may be of little significance in the healthy adult heart.
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Metadaten
Titel
Stabilised beta-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death
verfasst von
Alain Hirschy
Adrien Croquelois
Evelyne Perriard
Roman Schoenauer
Irina Agarkova
Simon P. Hoerstrup
Makoto M. Taketo
Thierry Pedrazzini
Jean-Claude Perriard
Elisabeth Ehler
Publikationsdatum
01.09.2010
Verlag
Springer-Verlag
Erschienen in
Basic Research in Cardiology / Ausgabe 5/2010
Print ISSN: 0300-8428
Elektronische ISSN: 1435-1803
DOI
https://doi.org/10.1007/s00395-010-0101-8

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