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28.11.2017 | Original Paper

Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques

verfasst von: Settimio Rossi, Carmine Santamaria, Rosa Boccia, Luigi De Rosa, Francesco Maria D’Alterio, Francesca Simonelli, Giuseppe De Rosa

Erschienen in: International Ophthalmology | Ausgabe 6/2018

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Abstract

Background

To evaluate the clinical results of standard, transepithelial (TE) and iontophoresis (I) corneal cross-linking (CXL), in patients with progressive keratoconus.

Methods

Thirty eyes of 30 patients with progressive keratoconus treated by CXL (10 by standard-CXL, 10 by TE-CXL and 10 by I-TE-CXL) with 12 months of follow-up. Pre- and postoperative ophthalmologic testing were: uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive examination (spherical error, spherical equivalent), corneal topography (corneal astigmatism, simulated maximum, minimum and average keratometry), aberrometry (coma and spherical aberration), pachymetry and endothelial cell density.

Results

In all groups, UDVA and CDVA improved significantly after treatment. Furthermore, a significant improvement in spherical error, spherical equivalent, topographic and aberrometric outcomes was observed in 3 groups at 1 year posttreatment. No significant variations were recorded in corneal thickness and endothelial cellular density.

Conclusion

Our results showed efficacy, clinical and refractive stability after standard-CXL, TE-CXL and iontophoresis-CXL.

Rabinowitz YS (1998) Keratoconus. Surv Ophthalmol 42:297–319CrossRef

Andreassen TT, Simonsen AH, Oxlund H (1980) Biomechanical properties of keratoconus and normal corneas. Exp Eye Res 31:435–441CrossRef

Wollensak G, Wilsch M, Spoerl E, Seiler T (2004) Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin/UVA. Cornea 23:503–507CrossRef

Wollensak G, Iomdina E (2009) Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35:540–546CrossRef

Mencucci R, Marini M, Gheri G et al (2011) Lectin binding in normal, keratoconus and cross-linked human corneas. Acta Histochem 113:308–316CrossRef

Spoerl E, Wollensak G, Seiler T (2004) Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 29:35–40CrossRef

Vinciguerra P, Albè E, Trazza S, Rosetta P, Vinciguerra R, Seiler T, Epstein D (2009) Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology 116:369–378CrossRef

Kamaev P, Friedman MD, Sherr E, Muller D (2012) Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci 53:2360–2367CrossRef

Zhang X, Tao XC, Zhang J, Li ZW, Xu YY, Wang YM, Zhang CX, Mu GY (2015) A review of collagen cross-linking in cornea and sclera. J Ophthalmol 2015:289467PubMedPubMedCentral

10.

Tabibian D, Richoz O, Hafezi F (2015) PACK-CXL: corneal cross-linking for treatment of infectious keratitis. J Ophthalmic Vis Res 10:77–80CrossRef

11.

Iseli HP, Thiel MA, Hafezi F, Kampmeier J, Seiler T (2008) Ultraviolet A/riboflavincorneal cross-linking for infectious keratitis associated with corneal melts. Cornea 27:590–594CrossRef

12.

Lee H, Kang DS, Ha BJ, Choi JY, Kim EK, Seo KY, Kim TI (2016) Changes in posterior corneal elevations after combined transepithelial photorefractive keratectomy and accelerated corneal collagen cross-linking: retrospective, comparative observational case series. BMC Ophthalmol 8(16):139CrossRef

13.

Ghanem RC, Santhiago MR, Berti TB, Thomaz S, Netto MV (2010) Collagen cross-linking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg 36:273–276CrossRef

14.

Vinciguerra R, Romano MR, Camesasca FI, Azzolini C, Trazza S, Morenghi E, Vinciguerra P (2013) Corneal cross-linking as a treatment for keratoconus: four-year morphologic and clinical outcomes with respect to patient age. Ophthalmology 120:908–916CrossRef

15.

O’Brart DP, Kwong TQ, Patel P, McDonald RJ, O’Brart NA (2013) Long-term follow-up of riboflavin/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus. Br J Ophthalmol 97:433–437CrossRef

16.

Caporossi A, Mazzotta C, Baiocchi S, Caporossi T (2010) Long-term results of riboflavin ultraviolet a corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149:585–593CrossRef

17.

Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE (2008) Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 34:796–801CrossRef

18.

Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, Caporossi A (2007) Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea 26:390–397CrossRef

19.

Mazzotta C, Traversi C, Baiocchi S, Caporossi O, Bovone C, Sparano MC, Balestrazzi A, Caporossi A (2008) Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 146:527–533CrossRef

20.

Caporossi A, Mazzotta C, Baiocchi S, Caporossi T, Paradiso AL (2012) Transepithelial corneal collagen crosslinking for keratoconus: qualitative investigation by in vivo HRT II confocal analysis. Eur J Ophthalmol 22(Suppl. 7):S81–S8830CrossRef

21.

Leccisotti A, Islam T (2010) Transepithelial corneal collagen crosslinking in keratoconus. J Refract Surg 26:942–948CrossRef

22.

Spadea L, Mencucci R (2012) Transepithelial corneal collagen cross-linking in ultrathin keratoconic corneas. Clin Ophthalmol 6:1785–1792CrossRef

23.

Caporossi A, Mazzotta C, Paradiso AL, Baiocchi S, Marigliani D, Caporossi T (2013) Transepithelial corneal collagen crosslinking for progressive keratoconus: 24-month clinical results. J Cataract Refract Surg 39:1157–1163CrossRef

24.

Rossi S, Orrico A, Santamaria C, Romano V, De Rosa L, Simonelli F, De Rosa G (2015) Standard versus trans-epithelial collagen cross-linking in keratoconus patients suitable for standard collagen cross-linking. Clin Ophthalmol 18(9):503–509CrossRef

25.

Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A (2009) Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg 35:893–899CrossRef

26.

Lang SJ, Messmer EM, Geerling G, Mackert MJ, Brunner T, Dollak S, Kutchoukov B, Böhringer D, Reinhard T, Maier P (2015) Prospective, randomized, double-blind trial to investigate the efficacy and safety of corneal cross-linking to halt the progression of keratoconus. BMC Ophthalmol 21(15):78CrossRef

27.

Xia Y, Chai X, Zhou C, Ren Q (2011) Corneal nerve morphology and sensitivity changes after ultraviolet A/riboflavin treatment. Exp Eye Res 93:541–547CrossRef

28.

Wollensak G, Spoerl E, Wilsch M, Seiler T (2004) Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment. Cornea 23:43–49CrossRef

29.

Ozgurhan EB, Akcay BIS, Yildirim Y, Karatas G, Kurt T, Demirok A (2014) Evaluation of corneal stromal demarcation line after two different protocols of accelerated corneal collagen cross-linking procedures using anterior segment optical coherence tomography and confocal microscopy. J Ophthalmol 2014:981893CrossRef

30.

Cassagne M, Laurent C, Rodrigues M, Galinier A, Spoerl E, Galiacy SD, Soler V, Fournié P, Malecaze F (2016) Iontophoresis transcorneal delivery technique for transepithelial corneal collagen crosslinking with riboflavin in a rabbit model. Invest Ophthalmol Vis Sci 57(2):594–603CrossRef

31.

Mastropasqua L, Lanzini M, Curcio C, Calienno R, Mastropasqua R, Colasante M, Mastropasqua A, Nubile M (2014) Structural modifications and tissue response after standard epi-off and iontophoretic corneal crosslinking with different irradiation procedures. Invest Ophthalmol Vis Sci 55:2526–2533CrossRef

32.

Franch A, Birattari F, Dal Mas G, Lužnik Z, Parekh M, Ferrari S, Ponzin D (2015) Evaluation of intrastromal riboflavin concentration in human corneas after three corneal cross-linking imbibition procedures: a pilot study. J Ophthalmol 2015:794256CrossRef

33.

Mazzotta C, Hafezi F, Kymionis G, Caragiuli S, Jacob S, Traversi C, Barabino S, Randleman JB (2015) In vivo confocal microscopy after corneal collagen crosslinking. Ocul Surf 13(4):298–314CrossRef

34.

Torres Munoz I, Grizzi F, Russo C, Camesasca FI, Dioguardi N, Vinciguerra P (2003) The role of amino acids in corneal stromal healing: a method for evaluating cellular density and extracellular matrix distribution. J Refract Surg 19:S227–S230PubMed

35.

Raiskup F, Pinelli R, Spoerl E (2012) Riboflavin osmolar modification for transepithelial corneal cross-linking. Curr Eye Res 37(3):234–238CrossRef

36.

Oltulu R, Şatirtav G, Donbaloğlu M, Kerimoğlu H, Özkağnici A, Karaibrahimoğlu A (2014) Intraoperative corneal thickness monitoring during corneal collagen cross-linking with isotonic riboflavin solution with and without dextran. Cornea 33(11):1164–1167CrossRef

37.

Bouheraoua N, Jouve L, Borderie V, Laroche L (2015) Three different protocols of corneal collagen crosslinking in keratoconus: conventional, accelerated and iontophoresis. J Vis Exp. https://doi.org/10.3791/53119

38.

Mastropasqua L, Nubile M, Calienno R, Mattei PA, Pedrotti E, Salgari N, Mastropasqua R, Lanzini M (2014) Corneal cross-linking: intrastromal riboflavin concentration in iontophoresis-assisted imbibition versus traditional and transepithelial techniques. Am J Ophthalmol 157(3):623–630CrossRef

39.

Vinciguerra P, Randleman JB, Romano V, Legrottaglie EF, Rosetta P, Camesasca FI, Piscopo R, Azzolini C, Vinciguerra R (2014) Transepithelial iontophoresis corneal collagen cross-linking for progressive keratoconus: initial clinical outcomes. J Refract Surg 30(11):746–753CrossRef

40.

Laborante A, Longo C, Mazzilli E, Giardinelli K (2015) Corneal iontophoresis and cross linking: a preliminary report of our experience. Clin Ter 166(4):e254–e256PubMed

41.

Vinciguerra P, Albe E, Trazza S, Seiler T, Epstein D (2009) Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol 127:1258–1265CrossRef

42.

Sharma A, Nottage JM, Mirchia K, Sharma R, Mohan K, Nirankari VS (2012) Persistent corneal edema after collagen cross-linking for keratoconus. Am J Ophthalmol 154(6):922–926CrossRef

43.

Rama P, Di Matteo F, Matuska S, Insacco C, Paganoni G (2011) Severe keratitis following corneal cross-linking for keratoconus. Acta Ophthalmol 89:e658–e659CrossRef

44.

Dhawan S, Rao K, Natrajan S (2011) Complications of corneal collagen cross-linking. J Ophthalmol 2011:869015CrossRef

Titel: Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques
verfasst von: Settimio Rossi
Carmine Santamaria
Rosa Boccia
Luigi De Rosa
Francesco Maria D’Alterio
Francesca Simonelli
Giuseppe De Rosa
Publikationsdatum: 28.11.2017
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 6/2018
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-017-0772-3

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Standard, transepithelial and iontophoresis corneal cross-linking: clinical analysis of three surgical techniques

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