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European Journal of Nuclear Medicine and Molecular Imaging

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01.01.2012 | Original Article

Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study

verfasst von: Kenichi Nakajima, Koichi Okuda, Shinro Matsuo, Mitsuhiro Yoshita, Junichi Taki, Masahito Yamada, Seigo Kinuya

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 1/2012

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Abstract

Purpose

This study was performed to demonstrate that the results obtained with a calibration phantom could be used as a tool for standardizing measurement of heart to mediastinum (H/M) ratio in cardiac metaiodobenzylguanidine (MIBG) imaging.

Methods

Images of the phantom containing ¹²³I-MIBG were acquired on the cameras in 10 hospitals (11 camera types) to determine the relationship between H/M ratios using different collimators: low-energy (LE) and medium-energy (ME)/low–medium-energy (LME) collimators. The effect of standardization on the ME-comparable H/M ratio was examined in two settings: a Japanese standard MIBG database (n = 62) and multicentre studies (n = 49). In a multicentre study, probable Alzheimer’s disease (AD, n = 18) and probable dementia with Lewy bodies (DLB, n = 31) were studied and standardized by the calibration phantom method.

Results

Linear regression equations between LE and ME collimators were obtained for the phantom study in all institutions. When the H/M ratio with an LE collimator was corrected based upon the calibration phantom, the corrected values were comparable to those obtained using ME collimators. The standard database also exhibited a normal distribution after standardization as determined by skewness and goodness-of-fit test. A mixture of the populations by LE and ME collimators showed significant separation of AD and DLB groups (F ratio = 24.9 for the late H/M), but the corrected values resulted in higher F ratios for both early and late H/M (F ratio = 34.9 for the late H/M).

Conclusion

Standardization of H/M ratios by the heart-chest calibration phantom method is feasible among different collimator types. This method could be practically used for multicentre comparison of H/M ratios.

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Titel: Standardization of metaiodobenzylguanidine heart to mediastinum ratio using a calibration phantom: effects of correction on normal databases and a multicentre study
verfasst von: Kenichi Nakajima
Koichi Okuda
Shinro Matsuo
Mitsuhiro Yoshita
Junichi Taki
Masahito Yamada
Seigo Kinuya
Publikationsdatum: 01.01.2012
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 1/2012
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1963-1

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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