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Current Reviews in Musculoskeletal Medicine

Erschienen in:

09.07.2018 | Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

verfasst von: Benjamin F. Ricciardi, Gowrishankar Muthukrishnan, Elysia Masters, Mark Ninomiya, Charles C. Lee, Edward M. Schwarz

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2018

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Abstract

Purpose of Review

The incidence of complications from prosthetic joint infection (PJI) is increasing, and treatment failure remains high. We review the current literature with a focus on Staphylococcus aureus pathogenesis and biofilm, as well as treatment challenges, and novel therapeutic strategies.

Recent Findings

S. aureus biofilm creates a favorable environment that increases antibiotic resistance, impairs host immunity, and increases tolerance to nutritional deprivation. Secreted proteins from bacterial cells within the biofilm and the quorum-sensing agr system contribute to immune evasion. Additional immunoevasive properties of S. aureus include the formation of staphylococcal abscess communities (SACs) and canalicular invasion. Novel approaches to target biofilm and increase resistance to implant colonization include novel antibiotic therapy, immunotherapy, and local implant treatments.

Summary

Challenges remain given the diverse mechanisms developed by S. aureus to alter the host immune responses. Further understanding of these processes should provide novel therapeutic mechanisms to enhance eradication after PJI.

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Titel: Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond
verfasst von: Benjamin F. Ricciardi
Gowrishankar Muthukrishnan
Elysia Masters
Mark Ninomiya
Charles C. Lee
Edward M. Schwarz
Publikationsdatum: 09.07.2018
Verlag: Springer US
Erschienen in: Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2018
Elektronische ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-018-9501-4

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Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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