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01.12.2018 | Research | Ausgabe 1/2018 Open Access

Malaria Journal 1/2018

State-dependent domicile leaving rates in Anopheles gambiae

Zeitschrift:
Malaria Journal > Ausgabe 1/2018
Autoren:
Simon P. W. Zappia, Alex M. Chubaty, Bernard D. Roitberg
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12936-017-2166-4) contains supplementary material, which is available to authorized users.

Abstract

Background

Transmission of Plasmodium greatly depends on the foraging behaviour of its mosquito vector (Anopheles spp.). The accessibility of blood hosts and availability of plant sugar (i.e., nectar) sources, together with mosquito energy state, have been shown to modulate blood feeding (and thus biting rates) of anopheline mosquitoes. In this study, the influence of mosquito starvation status and availability of nectar on the decision of female Anopheles gambiae mosquitoes to leave a bed net-protected blood host was examined.

Methods

Two small-scale mesocosm experiments were conducted using female mosquitoes starved for 0, 24 or 48 h, that were released inside a specially constructed hut with mesh-sealed exits and containing a bed net-protected human volunteer. Floral cues were positioned on one side of the hut or the other. Several biologically plausible exponential decay models were developed that characterized the emigration rates of mosquitoes from the huts. These varied from simple random loss to leaving rates dependent upon energy state and time. These model fits were evaluated by examining their fitted parameter estimates and comparing Akaike information criterion.

Results

Starved mosquitoes left domiciles at a higher rate than recently fed individuals however, there was no difference between 1- and 2-day-starved mosquitoes. There was also no effect of floral cue placement. The best fitting emigration model was one based on both mosquito energy state and time whereas the worst fitting model was one based on the assumption of constant leaving rates, independent of time and energy state.

Conclusions

The results confirm that mosquito-leaving behaviour is energy-state dependent, and provide some of the first evidence of state-dependent domicile emigration in An. gambiae, which may play a role in malarial transmission dynamics. Employment of simple, first-principle, mechanistic models can be very useful to our understanding of why and how mosquitoes leave domiciles.
Zusatzmaterial
Additional file 1. Evaluation of mosquito leaving rates based on starvation treatment and experiment end time using logistic regression.
Additional file 2. Comparison of fitted models’ residuals of mosquitoes collected in the hut over time. Treatment groups correspond to duration of mosquito starvation treatments (0, 24, 48 hrs). a) Model 0, leaving rate is independent of energy state; b) Model 1 or 2, individuals leave gradually based on energy state; c) Model 3 (constrained, see text), some proportion of individuals leave immediately, while others leave gradually based on energy state; d) Model 4, leaving rate depends on both energy state and time.
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