Statins in patients with sepsis and ARDS: is it over? Yes

Excerpt

Sepsis is associated with significant morbidity and mortality despite advances in treatment, technology and research. Therefore, multiple studies have focused on understanding the pathophysiology of sepsis to improve therapeutic options. We now know that infection triggers an inflammatory response and a compensatory anti-inflammatory response that is intended to minimize the damage from infection. In some patients, this inflammatory response could lead to further tissue damage and, subsequently, to multi-organ failure and acute respiratory distress syndrome (ARDS) [1]. Therefore, various immunomodulating and anti-inflammatory agents have been studied in the sepsis population. …