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Erschienen in: Reviews in Endocrine and Metabolic Disorders 4/2018

23.01.2019

Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: Immunomodulatory properties?

verfasst von: Christian A. Koch, Siegfried Krabbe, Bernd Hehmke

Erschienen in: Reviews in Endocrine and Metabolic Disorders | Ausgabe 4/2018

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Abstract

The immune system is closely intertwined with the endocrine system. Many effects of medications used for various clinical endocrine conditions such as the metabolic syndrome, hypercholesterolemia, diabetes mellitus, hypertension, Graves’ disease and others also have an impact on the immune system. Some drugs including statins, metformin, angiotensin converting enzyme and proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones are known to have immunomodulatory properties. We here review the literature on this topic and provide some clinical examples including the use of statins in Graves’ orbitopathy, rheumatoid arthritis, multiple sclerosis, and adult-onset Still’s disease. In that context, we introduce a special immunodiagnostics method developed at the Institute of  Diabetes “Gerhardt Katsch” in Karlsburg, Germany, to not only measure but also monitor immune disease activity.
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Metadaten
Titel
Statins, metformin, proprotein-convertase-subtilisin-kexin type-9 (PCSK9) inhibitors and sex hormones: Immunomodulatory properties?
verfasst von
Christian A. Koch
Siegfried Krabbe
Bernd Hehmke
Publikationsdatum
23.01.2019
Verlag
Springer US
Erschienen in
Reviews in Endocrine and Metabolic Disorders / Ausgabe 4/2018
Print ISSN: 1389-9155
Elektronische ISSN: 1573-2606
DOI
https://doi.org/10.1007/s11154-018-9478-8

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