Skip to main content

01.12.2014 | Research | Ausgabe 1/2014 Open Access

Molecular Autism 1/2014

Statistical analysis of twenty years (1993 to 2012) of data from mainland China’s first intervention center for children with autism spectrum disorder

Molecular Autism > Ausgabe 1/2014
Wei-Zhen Zhou, Adam Yongxin Ye, Zhong-Kai Sun, Hope Huiping Tian, Tad Zhengzhang Pu, Yu-Yu Wu, Dan-Dan Wang, Ming-Zhen Zhao, Shu-Juan Lu, Chang-Hong Yang, Liping Wei
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​2040-2392-5-52) contains supplementary material, which is available to authorized users.
Wei-Zhen Zhou, Adam Yongxin Ye, Zhong-Kai Sun contributed equally to this work.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

LW conceived the idea and designed the study. WZZ assisted in the study design, conducted the survey, and pre-processed the data. DDW and SJL assisted in the survey. CHY assisted in the data pre-processing. WZZ and AYY analyzed the data. WZZ, ZKS, HHT, AYY, and LW interpreted the results. DDW and MZZ conducted the ADI-R interviews. YYW and TP performed clinical re-diagnoses. WZZ, AYY, and LW wrote the manuscript. All authors read and approved the final manuscript.



Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interaction, and restrictive and repetitive patterns of behavior, interests or activities. This study aimed to analyze trends in ASD diagnosis and intervention in 20 years of data from the Beijing Stars and Rain Education Institute for Autism (SR), the first autism intervention center in mainland China, and from a recent survey of members of the Heart Alliance, an industry association of autism intervention centers in China.


We analyzed the registration data at the SR from 1993 to 2012 for a total of 2,222 children who had a parent-reported diagnosis of ASD and 612 of ‘autistic tendencies’. Most of the children who were the primary focus of our analyses were age six and under. We also analyzed results of a survey we conducted in 2013 of 100 member centers of the Heart Alliance. Generalized Estimating Equations, multiple linear regression and the Mann-Whitney test were used for data analysis. Statistically significant findings are reported here.


The number of hospitals where SR children received their diagnosis increased from several in the early 1990s to 276 at present. The proportion of ‘autistic tendencies’ diagnosis increased 2.04-fold from 1998 to 2012 and was higher for children diagnosed at a younger age. The mean age at first diagnosis of ASD or ‘autistic tendencies’ decreased by 0.27 years every decade. A higher level of parental education was statistically significantly associated with an earlier diagnosis of the child. The mean parental age at childbirth increased by about 1.48 years per decade, and the mean maternal age was 1.40 and 2.10 years higher than that in the national population censuses of 2000 and 2010, respectively. At the time of the survey 3,957 children with ASD were being trained at the 100 autism intervention centers. Ninety-seven of these centers opened after the year 2000. Economically underdeveloped regions are still underserved.


This study revealed encouraging trends and remaining challenges in ASD diagnosis and intervention among children at the SR over the past 20 years and the 100 autism intervention centers in China at present.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2014

Molecular Autism 1/2014 Zur Ausgabe

Neu in den Fachgebieten Neurologie und Psychiatrie