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Erschienen in: Calcified Tissue International 5/2014

01.11.2014 | Original Research

Stimulation of Titanium Implant Osseointegration Through High-Frequency Vibration Loading is Enhanced when Applied at High Acceleration

verfasst von: Toru Ogawa, Katleen Vandamme, Xiaolei Zhang, Ignace Naert, Tine Possemiers, Amol Chaudhari, Keiichi Sasaki, Joke Duyck

Erschienen in: Calcified Tissue International | Ausgabe 5/2014

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Abstract

Low-magnitude high-frequency loading, applied by means of whole body vibration (WBV), affects the bone. Deconstructing a WBV loading stimulus into its constituent elements and investigating the effects of frequency and acceleration individually on bone tissue kinetics around titanium implants were aimed for in this study. A titanium implant was inserted in the tibia of 120 rats. The rats were divided into 1 control group (no loading) and 5 test groups with low (L), medium (M) or high (H) frequency ranges and accelerations [12–30 Hz at 0.3×g (F L A H); 70–90 Hz at 0.075×g (F M A M); 70–90 Hz at 0.3×g (F M A H); 130–150 Hz at 0.043×g (F H A L); 130–150 Hz at 0.3×g (F H A H)]. WBV was applied for 1 or 4 weeks. Implant osseointegration was evaluated by quantitative histology (bone-to-implant contact (BIC) and peri-implant bone formation (BV/TV)). A 2-way ANOVA (duration of experimental period; loading mode) with α = 0.05 was performed. BIC significantly increased over time and under load (p < 0.0001). The highest BICs were found for loading regimes at high acceleration with medium or high frequency (F M A H and F H A H), and significantly differing from F L A H and F M A M (p < 0.02 and p < 0.005 respectively). BV/TV significantly decreased over time (p < 0.0001). Loading led to a site-specific BV/TV increase (p < 0.001). The highest BV/TV responses were found for F M A H and F H A H, significantly differing from F M A M (p < 0.005). The findings reveal the potential of high-frequency vibration loading to accelerate and enhance implant osseointegration, in particular when applied at high acceleration. Such mechanical signals hold great, though untapped, potential to be used as non-pharmacologic treatment for improving implant osseointegration in compromised bone.
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Metadaten
Titel
Stimulation of Titanium Implant Osseointegration Through High-Frequency Vibration Loading is Enhanced when Applied at High Acceleration
verfasst von
Toru Ogawa
Katleen Vandamme
Xiaolei Zhang
Ignace Naert
Tine Possemiers
Amol Chaudhari
Keiichi Sasaki
Joke Duyck
Publikationsdatum
01.11.2014
Verlag
Springer US
Erschienen in
Calcified Tissue International / Ausgabe 5/2014
Print ISSN: 0171-967X
Elektronische ISSN: 1432-0827
DOI
https://doi.org/10.1007/s00223-014-9896-x

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