STK11 mutation status is associated with decreased survival in meningiomas
- 07.04.2020
- Original Article
Erschienen in:
- Verfasst von
- Corey M. Gill
- Joshua Loewenstern
- John W. Rutland
- Hanane Arib
- Margaret Pain
- Melissa Umphlett
- Yayoi Kinoshita
- Russell B. McBride
- Joshua Bederson
- Michael Donovan
- Robert Sebra
- Mary Fowkes
- Raj K. Shrivastava
- Erschienen in
- Neurological Sciences | Ausgabe 9/2020
Abstract
Background
Emerging evidence suggests that STK11 mutations may influence clinical outcome and response to immunotherapy in cancer.
Materials and methods
Next-generation targeted sequencing of STK11 mutation status in a large cohort of 188 meningiomas.
Results
STK11 loss-of-function mutations were identified in 3.7% of meningiomas. STK11 mutations were found in both low- and high-grade lesions and samples from primary and recurrent disease. There was a 2.8-fold increased risk of death for patients whose meningioma harbored an STK11 mutation, after controlling for lesion grade and occurrence status. The median overall survival for patients with STK11-mutated meningiomas was 4.4 years compared with 16.8 years.
Conclusion
These data identify recurrent STK11 mutations in a subset of meningiomas. Genotyping of STK11 is encouraged for meningioma patients undergoing immunotherapy-based therapy.
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- Titel
- STK11 mutation status is associated with decreased survival in meningiomas
- Verfasst von
-
Corey M. Gill
Joshua Loewenstern
John W. Rutland
Hanane Arib
Margaret Pain
Melissa Umphlett
Yayoi Kinoshita
Russell B. McBride
Joshua Bederson
Michael Donovan
Robert Sebra
Mary Fowkes
Raj K. Shrivastava
- Publikationsdatum
- 07.04.2020
- Verlag
- Springer International Publishing
- Erschienen in
-
Neurological Sciences / Ausgabe 9/2020
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478 - DOI
- https://doi.org/10.1007/s10072-020-04372-y
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