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Erschienen in: NeuroTransmitter 11/2017

11.11.2017 | Fortbildung

GKV-Verordnung von Cannabis — Teil 2: Anwendungspraxis

Bei Cannabis auf BTM-Rezept Haftungs- und Regressrisiko beachten

verfasst von: Prof. Dr. med. Wolfgang Freund, Ludwig Laub, Prof. Dr. med. Ulrich W. Preuss

Erschienen in: NeuroTransmitter | Ausgabe 11/2017

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Zusammenfassung

Im ersten Teil dieses Artikels zur GKV-Verordnung von Cannabisprodukten wurden die derzeitige Evidenz zur Wirkung von Cannabis und relevante Aspekte zur Pharmakologie zusammengefasst. Dieser zweite Teil behandelt die praktische Anwendung von Cannabisprodukten und die rechtlichen Aspekte von BTM-Status über Fahreignung, Produkthaftung bis zur Patientenaufklärung und Regressgefahr.
Literatur
1.
Zurück zum Zitat Gesetz zur Änderung betäubungsmittelrechtlicher und anderer Vorschriften (2017). Bundesgesetzblatt, vol Teil I Nr. 11, 09.03.2017. Gesetz zur Änderung betäubungsmittelrechtlicher und anderer Vorschriften (2017). Bundesgesetzblatt, vol Teil I Nr. 11, 09.03.2017.
3.
Zurück zum Zitat Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I (2016) Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Scientific reports 6:33307. doi:10.1038/srep33307 Chen J, Varga A, Selvarajah S, Jenes A, Dienes B, Sousa-Valente J, Kulik A, Veress G, Brain SD, Baker D, Urban L, Mackie K, Nagy I (2016) Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk. Scientific reports 6:33307. doi:10.​1038/​srep33307
4.
Zurück zum Zitat Veress G, Meszar Z, Muszil D, Avelino A, Matesz K, Mackie K, Nagy I (2013) Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons. Brain structure & function 218(3):733–750. doi:10.1007/s00429-012-0425-2CrossRef Veress G, Meszar Z, Muszil D, Avelino A, Matesz K, Mackie K, Nagy I (2013) Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons. Brain structure & function 218(3):733–750. doi:10.​1007/​s00429-012-0425-2CrossRef
5.
Zurück zum Zitat Tan Q, Chen Q, Feng Z, Shi X, Tang J, Tao Y, Jiang B, Tan L, Feng H, Zhu G, Yang Y, Chen Z (2017) Cannabinoid receptor 2 activation restricts fibrosis and alleviates hydrocephalus after intraventricular hemorrhage. Brain research 1654 (Pt A):24-33. doi:10.1016/j.brainres.2016.10.016 Tan Q, Chen Q, Feng Z, Shi X, Tang J, Tao Y, Jiang B, Tan L, Feng H, Zhu G, Yang Y, Chen Z (2017) Cannabinoid receptor 2 activation restricts fibrosis and alleviates hydrocephalus after intraventricular hemorrhage. Brain research 1654 (Pt A):24-33. doi:10.​1016/​j.​brainres.​2016.​10.​016
7.
Zurück zum Zitat Pertwee RG (2008) The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. British journal of pharmacology 153(2):199–215. doi:10.1038/sj.bjp.0707442CrossRefPubMed Pertwee RG (2008) The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. British journal of pharmacology 153(2):199–215. doi:10.​1038/​sj.​bjp.​0707442CrossRefPubMed
8.
Zurück zum Zitat Bridgeman MB, Abazia DT (2017) Medicinal Cannabis: History, Pharmacology, And Implications for the Acute Care Setting. P & T: a peer-reviewed journal for formulary management 42(3):180–188 Bridgeman MB, Abazia DT (2017) Medicinal Cannabis: History, Pharmacology, And Implications for the Acute Care Setting. P & T: a peer-reviewed journal for formulary management 42(3):180–188
9.
Zurück zum Zitat Pertwee RG (2004) The pharmacology and therapeutic potential of cannabidiol.. In: Di Marzo V (ed) Cannabinoids. Kluwer Academic/ Plenum Publishers, New York, pp 32-83 Pertwee RG (2004) The pharmacology and therapeutic potential of cannabidiol.. In: Di Marzo V (ed) Cannabinoids. Kluwer Academic/ Plenum Publishers, New York, pp 32-83
10.
11.
Zurück zum Zitat Havemann-Reinecke U, Hoch E, Preuss UW, Kiefer F, Batra A, Gerlinger G, Hauth I (2017) [On the legalization debate of non-medical cannabis consumption: Position paper of the German Association for Psychiatry, Psychotherapy and Psychosomatics]. Der Nervenarzt 88(3):291–298. doi:10.1007/s00115-016-0248-0CrossRefPubMed Havemann-Reinecke U, Hoch E, Preuss UW, Kiefer F, Batra A, Gerlinger G, Hauth I (2017) [On the legalization debate of non-medical cannabis consumption: Position paper of the German Association for Psychiatry, Psychotherapy and Psychosomatics]. Der Nervenarzt 88(3):291–298. doi:10.​1007/​s00115-016-0248-0CrossRefPubMed
12.
Zurück zum Zitat Elzinga S, Fischedick J, Podkolinski R, Raber JC (2015) Cannabinoids and Terpenes as Chemotaxonomic Markers in Cannabis. Natural Products Chemistry & Research 3(4):1–9. doi:10.4172/2329-6836.1000181 Elzinga S, Fischedick J, Podkolinski R, Raber JC (2015) Cannabinoids and Terpenes as Chemotaxonomic Markers in Cannabis. Natural Products Chemistry & Research 3(4):1–9. doi:10.​4172/​2329-6836.​1000181
13.
Zurück zum Zitat Bussik D, Eckert-Lill C (2017) Cannabis als Medizin: Was kommt auf die Apotheken zu? Pharmazeutische Zeitung online 2017 (08) Bussik D, Eckert-Lill C (2017) Cannabis als Medizin: Was kommt auf die Apotheken zu? Pharmazeutische Zeitung online 2017 (08)
14.
Zurück zum Zitat Müller-Vahl K, Grotenhermen F (2017) Medizinisches Cannabis: Die wichtigsten Änderungen. Deutsches Arzteblatt international 114(8):352–356 Müller-Vahl K, Grotenhermen F (2017) Medizinisches Cannabis: Die wichtigsten Änderungen. Deutsches Arzteblatt international 114(8):352–356
18.
Zurück zum Zitat Almirall (2015) Sativex Spray zur Anwendung in der Mundhöhle - Fachinformation. https://http://www.almirallmed.de/documents/10327/18203/Sativex_Spray_zur_Anwendung_in_der_Mundhoehle_Fachinformation.pdf/be19eca4-d8be-4493-93fe-355d0bdfe1e7. Accessed 5.July2017 2017 Almirall (2015) Sativex Spray zur Anwendung in der Mundhöhle - Fachinformation. https://http://​www.​almirallmed.​de/​documents/10327/18203/Sativex_Spray_zur_Anwendung_in_der_Mundhoehle_Fachinformation.pdf/be19eca4-d8be-4493-93fe-355d0bdfe1e7. Accessed 5.July2017 2017
19.
Zurück zum Zitat AOP_Orphan_Pharmaceuticals (2016) Canemes Fachinformation. Rote Liste Fachinfo Service. Rote Liste Fachinfo Service, Frankfurt AOP_Orphan_Pharmaceuticals (2016) Canemes Fachinformation. Rote Liste Fachinfo Service. Rote Liste Fachinfo Service, Frankfurt
20.
Zurück zum Zitat Bundesinstitut_für_Arzneimittel_und_Medizinprodukte (2017) Cannabis als Medizin: Bundesinstitut für Arzneimittel und Medizinprodukte richtet Cannabisagentur für künftigen Cannabisanbau in Deutschland ein. BfArM. http://www.bfarm.de/SharedDocs/Pressemitteilungen/DE/2017/pm7-2017.html. Accessed 5.July2017 2017 Bundesinstitut_für_Arzneimittel_und_Medizinprodukte (2017) Cannabis als Medizin: Bundesinstitut für Arzneimittel und Medizinprodukte richtet Cannabisagentur für künftigen Cannabisanbau in Deutschland ein. BfArM. http://​www.​bfarm.​de/​SharedDocs/Pressemitteilungen/DE/2017/pm7-2017.html. Accessed 5.July2017 2017
21.
Zurück zum Zitat Arzneimittelkommission_der_deutschen_Ärzteschaft (2015) Cannabinoide in der Medizin. Arzneimittelkommission_der_deutschen_Ärzteschaft. Arzneimittelkommission_der_deutschen_Ärzteschaft, Berlin Arzneimittelkommission_der_deutschen_Ärzteschaft (2015) Cannabinoide in der Medizin. Arzneimittelkommission_der_deutschen_Ärzteschaft. Arzneimittelkommission_der_deutschen_Ärzteschaft, Berlin
22.
Zurück zum Zitat National Academies of Sciences E, Medicine (2017) The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. The National Academies Press, Washington, DC. doi:doi:10.17226/24625 National Academies of Sciences E, Medicine (2017) The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. The National Academies Press, Washington, DC. doi:doi:10.​17226/​24625
23.
25.
Zurück zum Zitat Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S, McQuade R, Wright S, Fallon MT (2012) Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain 13(5):438–449. doi:10.1016/j.jpain.2012.01.003CrossRefPubMed Portenoy RK, Ganae-Motan ED, Allende S, Yanagihara R, Shaiova L, Weinstein S, McQuade R, Wright S, Fallon MT (2012) Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial. J Pain 13(5):438–449. doi:10.​1016/​j.​jpain.​2012.​01.​003CrossRefPubMed
27.
Zurück zum Zitat Wade DT, Makela P, Robson P, House H, Bateman C (2004) Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Multiple sclerosis (Houndmills, Basingstoke, England) 10(4):434–441. doi:10.1191/1352458504ms1082oaCrossRef Wade DT, Makela P, Robson P, House H, Bateman C (2004) Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients. Multiple sclerosis (Houndmills, Basingstoke, England) 10(4):434–441. doi:10.​1191/​1352458504ms1082​oaCrossRef
28.
Zurück zum Zitat Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J (2015) Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA 313(24):2456–2473. doi:10.1001/jama.2015.6358CrossRefPubMed Whiting PF, Wolff RF, Deshpande S, Di Nisio M, Duffy S, Hernandez AV, Keurentjes JC, Lang S, Misso K, Ryder S, Schmidlkofer S, Westwood M, Kleijnen J (2015) Cannabinoids for Medical Use: A Systematic Review and Meta-analysis. JAMA 313(24):2456–2473. doi:10.​1001/​jama.​2015.​6358CrossRefPubMed
29.
30.
31.
Zurück zum Zitat Jetly R, Heber A, Fraser G, Boisvert D (2015) The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Psychoneuroendocrinology 51:585–588. doi:10.1016/j.psyneuen.2014.11.002CrossRefPubMed Jetly R, Heber A, Fraser G, Boisvert D (2015) The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study. Psychoneuroendocrinology 51:585–588. doi:10.​1016/​j.​psyneuen.​2014.​11.​002CrossRefPubMed
32.
Zurück zum Zitat Fitzcharles MA, Baerwald C, Ablin J, Hauser W (2016) Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis): A systematic review of randomized controlled trials. Schmerz (Berlin, Germany) 30(1):47–61. doi:10.1007/s00482-015-0084-3CrossRef Fitzcharles MA, Baerwald C, Ablin J, Hauser W (2016) Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases (fibromyalgia syndrome, back pain, osteoarthritis, rheumatoid arthritis): A systematic review of randomized controlled trials. Schmerz (Berlin, Germany) 30(1):47–61. doi:10.​1007/​s00482-015-0084-3CrossRef
33.
Zurück zum Zitat Light M, Orens A, Lewandowski B, Pickton T (2014) Market size and demand for marijuana in Colorado. State of Colorado. http://www.colorado.gov/pacific/sites/default/files/Market%20Size%20and%20Demand%20Study,%20July%209,%202014%5B1%5D.pdf. Accessed 25.07.2017 2017 Light M, Orens A, Lewandowski B, Pickton T (2014) Market size and demand for marijuana in Colorado. State of Colorado. http://​www.​colorado.​gov/​pacific/sites/default/files/Market%20Size%20and%20Demand%20Study,%20July%209,%202014%5B1%5D.pdf. Accessed 25.07.2017 2017
38.
Zurück zum Zitat Snedecor SJ, Sudharshan L, Cappelleri JC, Sadosky A, Desai P, Jalundhwala YJ, Botteman M (2013) Systematic review and comparison of pharmacologic therapies for neuropathic pain associated with spinal cord injury. Journal of pain research 6:539–547. doi:10.2147/JPR.S45966CrossRefPubMedPubMedCentral Snedecor SJ, Sudharshan L, Cappelleri JC, Sadosky A, Desai P, Jalundhwala YJ, Botteman M (2013) Systematic review and comparison of pharmacologic therapies for neuropathic pain associated with spinal cord injury. Journal of pain research 6:539–547. doi:10.​2147/​JPR.​S45966CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Richards BL, Whittle SL, van der Heijde DM, Buchbinder R (2012) Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review. The Journal of rheumatology Supplement 90:28–33. doi:10.3899/jrheum.120339CrossRefPubMed Richards BL, Whittle SL, van der Heijde DM, Buchbinder R (2012) Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review. The Journal of rheumatology Supplement 90:28–33. doi:10.​3899/​jrheum.​120339CrossRefPubMed
41.
Zurück zum Zitat Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D (2014) Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 82 (17):1556–1563. doi:10.1212/WNL.0000000000000363CrossRefPubMedPubMedCentral Koppel BS, Brust JC, Fife T, Bronstein J, Youssof S, Gronseth G, Gloss D (2014) Systematic review: efficacy and safety of medical marijuana in selected neurologic disorders: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology 82 (17):1556–1563. doi:10.​1212/​WNL.​0000000000000363​CrossRefPubMedPubMedCentral
42.
Zurück zum Zitat Ashworth B (1964) Preliminary Trial of Carisoprodol in Multiple Sclerosis. The Practitioner 192:540–542PubMed Ashworth B (1964) Preliminary Trial of Carisoprodol in Multiple Sclerosis. The Practitioner 192:540–542PubMed
43.
Zurück zum Zitat Pandyan AD, Johnson GR, Price CI, Curless RH, Barnes MP, Rodgers H (1999) A review of the properties and limitations of the Ashworth and modified Ashworth Scales as measures of spasticity. Clinical rehabilitation 13(5):373–383. doi:10.1191/026921599677595404CrossRefPubMed Pandyan AD, Johnson GR, Price CI, Curless RH, Barnes MP, Rodgers H (1999) A review of the properties and limitations of the Ashworth and modified Ashworth Scales as measures of spasticity. Clinical rehabilitation 13(5):373–383. doi:10.​1191/​0269215996775954​04CrossRefPubMed
44.
Zurück zum Zitat Wade DT, Collin C, Stott C, Duncombe P (2010) Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 16(6):707–714. doi:10.1177/1352458510367462CrossRef Wade DT, Collin C, Stott C, Duncombe P (2010) Meta-analysis of the efficacy and safety of Sativex (nabiximols), on spasticity in people with multiple sclerosis. Multiple sclerosis (Houndmills, Basingstoke, England) 16(6):707–714. doi:10.​1177/​1352458510367462​CrossRef
45.
Zurück zum Zitat Carroll CB, Bain PG, Teare L, Liu X, Joint C, Wroath C, Parkin SG, Fox P, Wright D, Hobart J, Zajicek JP (2004) Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. Neurology 63(7):1245–1250CrossRefPubMed Carroll CB, Bain PG, Teare L, Liu X, Joint C, Wroath C, Parkin SG, Fox P, Wright D, Hobart J, Zajicek JP (2004) Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study. Neurology 63(7):1245–1250CrossRefPubMed
46.
Zurück zum Zitat Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM (2001) Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: a pilot study. Neurology 57(11):2108–2111CrossRefPubMed Sieradzan KA, Fox SH, Hill M, Dick JP, Crossman AR, Brotchie JM (2001) Cannabinoids reduce levodopa-induced dyskinesia in Parkinson’s disease: a pilot study. Neurology 57(11):2108–2111CrossRefPubMed
47.
Zurück zum Zitat Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA (2014) Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial. J Psychopharmacol 28(11):1088–1098. doi:10.1177/0269881114550355CrossRefPubMed Chagas MH, Zuardi AW, Tumas V, Pena-Pereira MA, Sobreira ET, Bergamaschi MM, dos Santos AC, Teixeira AL, Hallak JE, Crippa JA (2014) Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial. J Psychopharmacol 28(11):1088–1098. doi:10.​1177/​0269881114550355​CrossRefPubMed
48.
51.
Zurück zum Zitat Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR (2016) Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet neurology 15(3):270–278. doi:10.1016/S1474-4422(15)00379-8CrossRefPubMed Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR (2016) Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet neurology 15(3):270–278. doi:10.​1016/​S1474-4422(15)00379-8CrossRefPubMed
53.
Zurück zum Zitat Mechoulam R, Carlini EA (1978) Toward drugs derived from cannabis. Die Naturwissenschaften 65 (4):174–179CrossRefPubMed Mechoulam R, Carlini EA (1978) Toward drugs derived from cannabis. Die Naturwissenschaften 65 (4):174–179CrossRefPubMed
54.
Zurück zum Zitat Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R (1980) Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 21(3):175–185CrossRefPubMed Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R (1980) Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology 21(3):175–185CrossRefPubMed
55.
Zurück zum Zitat Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O (2015) Cannabinoids and Epilepsy. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics 12(4):747–768. doi:10.1007/s13311-015-0375-5 Rosenberg EC, Tsien RW, Whalley BJ, Devinsky O (2015) Cannabinoids and Epilepsy. Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics 12(4):747–768. doi:10.​1007/​s13311-015-0375-5
56.
Zurück zum Zitat Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B (2016) CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Seizure 35:41–44. doi:10.1016/j.seizure.2016.01.004CrossRefPubMed Tzadok M, Uliel-Siboni S, Linder I, Kramer U, Epstein O, Menascu S, Nissenkorn A, Yosef OB, Hyman E, Granot D, Dor M, Lerman-Sagie T, Ben-Zeev B (2016) CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience. Seizure 35:41–44. doi:10.​1016/​j.​seizure.​2016.​01.​004CrossRefPubMed
57.
Zurück zum Zitat Krishnan S, Cairns R, Howard R (2009) Cannabinoids for the treatment of dementia. Cochrane Database Syst Rev (2):CD007204. doi:10.1002/14651858.CD007204.pub2 Krishnan S, Cairns R, Howard R (2009) Cannabinoids for the treatment of dementia. Cochrane Database Syst Rev (2):CD007204. doi:10.1002/14651858.CD007204.pub2
58.
60.
Zurück zum Zitat Behrendt S, Wittchen HU, Hofler M, Lieb R, Beesdo K (2009) Transitions from first substance use to substance use disorders in adolescence: is early onset associated with a rapid escalation? Drug and alcohol dependence 99(1-3):68–78. doi:{rs 10.1016/j.drugalcdep.2008.06.014 DOI}}CrossRefPubMed Behrendt S, Wittchen HU, Hofler M, Lieb R, Beesdo K (2009) Transitions from first substance use to substance use disorders in adolescence: is early onset associated with a rapid escalation? Drug and alcohol dependence 99(1-3):68–78. doi:{rs 10.1016/j.drugalcdep.2008.06.014 DOI}}CrossRefPubMed
61.
Zurück zum Zitat 61. -Europäischen_Union AfVd (2015) Europäischer Drogenbericht 2015. In: Drogensucht EBfDu (ed) 61. -Europäischen_Union AfVd (2015) Europäischer Drogenbericht 2015. In: Drogensucht EBfDu (ed)
62.
Zurück zum Zitat Drogenbeauftragte_der_Bundesregierung (2016) Drogen- und Suchtbericht 2016 vorgestellt: Mehr Achtsamkeit für unsere Gesundheit schaffen! http://www.drogenbeauftragte.de/presse/pressekontakt-und-mitteilungen/2016/2016-2-quatarl/drogen-und-suchtbericht-2016-vorgestellt-mehr-achtsamkeit-fuer-unsere-gesundheit-schaffen.html. Accessed 25.07.2017 2017 Drogenbeauftragte_der_Bundesregierung (2016) Drogen- und Suchtbericht 2016 vorgestellt: Mehr Achtsamkeit für unsere Gesundheit schaffen! http://​www.​drogenbeauftragt​e.​de/​presse/pressekontakt-und-mitteilungen/2016/2016-2-quatarl/drogen-und-suchtbericht-2016-vorgestellt-mehr-achtsamkeit-fuer-unsere-gesundheit-schaffen.html. Accessed 25.07.2017 2017
65.
66.
Zurück zum Zitat Myles N, Newall H, Nielssen O, Large M (2012) The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factors. Current pharmaceutical design 18(32):5055–5069CrossRefPubMed Myles N, Newall H, Nielssen O, Large M (2012) The association between cannabis use and earlier age at onset of schizophrenia and other psychoses: meta-analysis of possible confounding factors. Current pharmaceutical design 18(32):5055–5069CrossRefPubMed
67.
Zurück zum Zitat van der Meer FJ, Velthorst E, Meijer CJ, Machielsen MW, de Haan L (2012) Cannabis use in patients at clinical high risk of psychosis: impact on prodromal symptoms and transition to psychosis. Current pharmaceutical design 18(32):5036–5044CrossRefPubMed van der Meer FJ, Velthorst E, Meijer CJ, Machielsen MW, de Haan L (2012) Cannabis use in patients at clinical high risk of psychosis: impact on prodromal symptoms and transition to psychosis. Current pharmaceutical design 18(32):5036–5044CrossRefPubMed
70.
Zurück zum Zitat Silins E, Fergusson DM, Patton GC, Horwood LJ, Olsson CA, Hutchinson DM, Degenhardt L, Tait RJ, Borschmann R, Coffey C, Toumbourou JW, Najman JM, Mattick RP, Cannabis Cohorts Research C (2015) Adolescent substance use and educational attainment: An integrative data analysis comparing cannabis and alcohol from three Australasian cohorts. Drug and alcohol dependence 156:90–96. doi:10.1016/j.drugalcdep.2015.08.034CrossRefPubMed Silins E, Fergusson DM, Patton GC, Horwood LJ, Olsson CA, Hutchinson DM, Degenhardt L, Tait RJ, Borschmann R, Coffey C, Toumbourou JW, Najman JM, Mattick RP, Cannabis Cohorts Research C (2015) Adolescent substance use and educational attainment: An integrative data analysis comparing cannabis and alcohol from three Australasian cohorts. Drug and alcohol dependence 156:90–96. doi:10.​1016/​j.​drugalcdep.​2015.​08.​034CrossRefPubMed
71.
Zurück zum Zitat Gentes EL, Schry AR, Hicks TA, Clancy CP, Collie CF, Kirby AC, Dennis MF, Hertzberg MA, Beckham JC, Calhoun PS (2016) Prevalence and correlates of cannabis use in an outpatient VA posttraumatic stress disorder clinic. Psychology of addictive behaviors: journal of the Society of Psychologists in Addictive Behaviors 30(3):415–421. doi:10.1037/adb0000154CrossRef Gentes EL, Schry AR, Hicks TA, Clancy CP, Collie CF, Kirby AC, Dennis MF, Hertzberg MA, Beckham JC, Calhoun PS (2016) Prevalence and correlates of cannabis use in an outpatient VA posttraumatic stress disorder clinic. Psychology of addictive behaviors: journal of the Society of Psychologists in Addictive Behaviors 30(3):415–421. doi:10.​1037/​adb0000154CrossRef
73.
Zurück zum Zitat Wilkinson ST, Stefanovics E, Rosenheck RA (2015) Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder. The Journal of clinical psychiatry 76(9):1174–1180. doi:10.4088/JCP.14m09475CrossRefPubMed Wilkinson ST, Stefanovics E, Rosenheck RA (2015) Marijuana use is associated with worse outcomes in symptom severity and violent behavior in patients with posttraumatic stress disorder. The Journal of clinical psychiatry 76(9):1174–1180. doi:10.​4088/​JCP.​14m09475CrossRefPubMed
74.
75.
Zurück zum Zitat Medizinischer_Dienst_des_Spitzenverbandes_Bund_der_Krankenkassen (2017) Fragen und Antworten zur neuen Regelung zu Cannabinoiden in der GKV. MDS e.V. MDS e.V., Essen Medizinischer_Dienst_des_Spitzenverbandes_Bund_der_Krankenkassen (2017) Fragen und Antworten zur neuen Regelung zu Cannabinoiden in der GKV. MDS e.V. MDS e.V., Essen
76.
Zurück zum Zitat § 24 a 0,5 Promillegrenze (2014). STVG Straßenverkehrsgesetz. § 24 a 0,5 Promillegrenze (2014). STVG Straßenverkehrsgesetz.
Metadaten
Titel
GKV-Verordnung von Cannabis — Teil 2: Anwendungspraxis
Bei Cannabis auf BTM-Rezept Haftungs- und Regressrisiko beachten
verfasst von
Prof. Dr. med. Wolfgang Freund
Ludwig Laub
Prof. Dr. med. Ulrich W. Preuss
Publikationsdatum
11.11.2017
Verlag
Springer Medizin
Erschienen in
NeuroTransmitter / Ausgabe 11/2017
Print ISSN: 1436-123X
Elektronische ISSN: 2196-6397
DOI
https://doi.org/10.1007/s15016-017-6196-5

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