Our systematic review will include randomized controlled trials only, including cluster randomized controlled trials. English language trials published in the last 17 years (i.e., since 2000) will be included. This time frame was selected to ensure the relevancy of the findings in the current healthcare context as well as feasibility. Trials will be eligible if they examine a predefined list of quality improvement strategies for adults (≥ 18 years of age) post-stroke. Quality improvement strategies will include those targeted at health systems (e.g., team changes), health care professionals (e.g., professional reminders), or patients (e.g., reminders). The particular strategies will include audit and feedback, case management, team changes, electronic patient registries, clinician education, clinical reminders, facilitated relay of clinical information to clinicians, patient education, (promotion of) self-management, patient reminder systems, and continuous quality improvement. This list of quality improvement strategies has been previously identified through other systematic reviews and meta-analyses (i.e., Shojania et al., 2006; Tricco et al., 2012) [
14,
15]. Outcomes of interest will be quality of life (primary) and physical and psychological well-being (secondary). Quality of life is operationalized as an individual’s perception of position in life in the context of the culture and value systems in which he or she lives and in relation to their goals, expectations, standards, and concerns [
16]. Well-being is defined as (1) a subjective or objective perception of improvement in physical health or of symptoms related to stroke or to side effects of treatment, and/or (2) a subjective or objective perception of improvement of psychological functioning [
16]. Quality of life must be specifically identified as the primary outcome measure to be included in the analysis. Furthermore, studies must report on quality of life as measured by validated scales, classifications, and measurement systems (e.g., the Short-Form-36 (SF-36), the Individual Quality of Life Interview). These measures must have been previously used in a stroke population. Similarly, studies will only be included if they report on well-being as measured by validated and specific standardized impairment, distress, or psychological scales (e.g., Center for Epidemiologic Studies Depression Scale (CESD) [
17], Hospital Anxiety and Depression Scale (HADS) [
18]), and if they have been previously used in a stroke population.