The online version of this article (doi:10.1186/1471-2261-14-1) contains supplementary material, which is available to authorized users.
All authors declare no competing interests.
AW and FH designed the study. FH coordinated the study. EvR managed the study and data collection. HvdH performed all echocardiographies. AL, ML and FH were members of the expert panel. EvR conducted the data analyses and wrote the first draft of the manuscript. All authors read and approved the final draft of the manuscript.
Most patients with heart failure are diagnosed and managed in primary care, however, underdiagnosis and undertreatment are common. We assessed whether implementation of a diagnostic-therapeutic strategy improves functionality, health-related quality of life, and uptake of heart failure medication in primary care.
A selective screening study followed by a single-blind cluster randomized trial in primary care. The study population consists of patients aged 65 years or over who presented themselves to the general practitioner in the previous 12 months with shortness of breath on exertion. Patients already known with established heart failure, confirmed by echocardiography, are excluded. Diagnostic investigations include history taking, physical examination, electrocardiography, and serum N-terminal pro B-type natriuretic peptide levels. Only participants with an abnormal electrocardiogram or an N-terminal pro B-type natriuretic peptide level exceeding the exclusionary cutpoint for non-acute onset heart failure (> 15 pmol/L (≈ 125 pg/ml)) will undergo open-access echocardiography. The diagnosis of heart failure (with reduced or preserved ejection fraction) is established by an expert panel consisting of two cardiologists and a general practitioner, according to the criteria of the European Society of Cardiology guidelines.
Patients with newly established heart failure are allocated to either the 'care as usual’ group or the 'intervention’ group. Randomization is at the level of the general practitioner. In the intervention group general practitioners receive a single half-day training in heart failure management and the use of a structured up-titration scheme. All participants fill out quality of life questionnaires at baseline and after six months of follow-up. A six-minute walking test will be performed in patients with heart failure. Information on medication and hospitalization rates is extracted from the electronic medical files of the general practitioners.
This study will provide information on the prevalence of unrecognized heart failure in elderly with shortness of breath on exertion, and the randomized comparison will reveal whether management based on a half-day training of general practitioners in the practical application of an up-titration scheme results in improvements in functionality, health-related quality of life, and uptake of heart failure medication in heart failure patients compared to care as usual.
Additional file 1: Initiation- and up-titration scheme for patient with newly, screen-detected HF. Scheme handed to participating GPs to facilitate easy initiation and up-titration of heart failure medication in patients with newly, screen-detected HF. Also includes contra-indications of medications, instructions for common barriers experienced during up-titration, and a reminder for periodic check-ups. (DOC 234 KB)
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- Strategy to recognize and initiate treatment of chronic heart failure in primary care (STRETCH): a cluster randomized trial
Evelien ES van Riet
Arno W Hoes
Henk van der Hoeven
Marcel AJ Landman
Frans H Rutten
- BioMed Central
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