Background
Methods
Data
Histological group | ICD-O-3 Morphology |
---|---|
Sarcomas NOS | 8800–8806 |
Fibrosarcomas | 8810–8840 |
Liposarcomas | 8850–8881 |
Uterine leiomysarcomas | 8890–8896, ICD-O-3 Topography C53, C54 |
Non-uterine leiomyosarcomas | 8890–8896, ICD-O-3 Topography not C53, C54 |
Rhabdomyosarcomas | 8900–8921 |
Complex mixed and stromal neoplasms (ICD-O-3), Others | 8711, 8930–8991, 9040–9044, 9580–9581 |
Phylloides tumour | 9020 |
Angiosarcomas | 9120–9175 |
Osteosarcomas | 9180–9210 |
Chondosarcomas | 9220–9243 |
Giant cell neoplasia | 9250–9252 |
Ewing family of tumours | 9260, 9364, 9365 |
Malignant ameloblastomas | 9261, 9310 |
Chordomas | 9370–9373 |
Nerve sheath tumours | 9540–9571 |
Analysis
Results
Descriptive epidemiology and incidence rates according to sarcoma entities
Characteristics | Men | Women | Ratio Men/Women | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
n | % | Incidence per 100,000 | Median age at diagnosis | n | % | Incidence per 100,000 | Median age at diagnosis | ||||
Crude | Age-Standa | Crude | Age-Standa | ||||||||
All | 3404 | 100 | 10.0 | 7.4 (7.2–7.7) | 67.4 | 3442 | 100 | 9.6 | 6.6 (6.3–6.8) | 67.7 | 1: 1 |
Allb | 3363 | 100 | 9.8 | 7.3 (7.1–7.6) | 67.4 | 3094 | 100 | 8.7 | 6.0 (5.7–6.2) | 67.3 | 1.1: 1 |
Type of sarcoma | |||||||||||
Soft tissue sarcoma | 2371 | 69.7 | 6.9 | 5.1 (4.9–5.3) | 68.4 | 2556 | 74.3 | 7.1 | 4.8 (4.6–5.0) | 68.0 | 1: 1.1 |
Soft tissue sarcomab | 2334 | 69.4 | 6.8 | 5.0 (4.8–5.3) | 68.3 | 2214 | 71.6 | 6.2 | 4.2 (4.0–4.4) | 67.3 | 1.1: 1 |
Bone sarcoma | 299 | 8.8 | 0.9 | 0.8 (0.7–0.9) | 49.8 | 267 | 7.8 | 0.7 | 0.7 (0.6–0.8) | 54.0 | 1.1: 1 |
Bone sarcomab | 295 | 8.8 | 0.9 | 0.8 (0.7–0.9) | 49.8 | 261 | 8.4 | 0.7 | 0.7 (0.6–0.8) | 54.2 | 1.1: 1 |
GIST | 734 | 21.6 | 2.1 | 1.5 (1.4–1.6) | 69.5 | 619 | 18.0 | 1.7 | 1.1 (1.0–1.2) | 70.2 | 1.2: 1 |
Age at diagnosis (years) | |||||||||||
0–14 | 97 | 2.8 | 0.3 | – | – | 68 | 2.0 | 0.2 | – | – | 1.4: 1 |
15–29 | 158 | 4.6 | 0.5 | – | – | 117 | 3.4 | 0.3 | – | – | 1.4: 1 |
30–49 | 434 | 12.7 | 1.3 | – | – | 493 | 14.3 | 1.4 | – | – | 1: 1.1 |
50–69 | 1182 | 34.7 | 3.5 | – | – | 1214 | 35.3 | 3.4 | – | – | 1: 1 |
70+ | 1533 | 45.0 | 4.5 | – | – | 1550 | 45.0 | 4.3 | – | – | 1: 1 |
Total | 3404 | 100 | 10.0 | 7.4 | 67.4 | 3442 | 100 | 9.6 | 6.6 | 67.7 | 1: 1 |
Subanalysis according to histological groups
Diagnostic group | Men | Women | Sex ratio (M/F) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Cases | Incidence rate per 100,000 per year | Age at diagnosis (Median) | Cases | Incidence rate per 100,000 per year | Age at diagnosis (Median) | ||||||
N | % | Crude | Age-standa | N | % | Crude | Age-standa | ||||
Sarcoma, NOS
|
645
|
18.9
|
1.9
|
1.3
|
71.4
|
470
|
13.7
|
1.3
|
0.8
|
71.5
| 1.4: 1 |
Sarcoma, NOS | 317 | 9.3 | 0.9 | 0.6 | 71.9 | 290 | 8.4 | 0.8 | 0.5 | 71.5 | 1.1: 1 |
Spindle cell sarcoma | 72 | 2.1 | 0.2 | 0.1 | 73.5 | 53 | 1.5 | 0.1 | 0.1 | 73.4 | 1.4: 1 |
Giant cell sarcoma | 170 | 5.0 | 0.5 | 0.3 | 72.9 | 87 | 2.5 | 0.2 | 0.1 | 72.5 | 2: 1 |
Small cell sarcoma | 7 | 0.2 | 0.0 | 0.0 | 41.8 | 3 | 0.1 | 0.0 | 0.0 | 46.2 | 2.3: 1 |
Undifferentiated sarcoma | 42 | 1.2 | 0.1 | 0.1 | 64.4 | 21 | 0.6 | 0.1 | 0.0 | 64.0 | 2: 1 |
Fibrosarcoma
|
475
|
14.0
|
1.4
|
1.0
|
71.0
|
305
|
8.9
|
0.9
|
0.6
|
61.5
| 1.6: 1 |
Fibrosarcoma, NOS | 48 | 1.4 | 0.1 | 0.1 | 64.0 | 36 | 1.0 | 0.1 | 0.1 | 67.3 | 1.3: 1 |
Fibromyxosarcoma | 82 | 2.4 | 0.2 | 0.2 | 70.3 | 59 | 1.7 | 0.2 | 0.1 | 68.3 | 1.4: 1 |
Malignant fibrous histiocytoma | 198 | 5.8 | 0.6 | 0.3 | 77.0 | 77 | 2.2 | 0.2 | 0.1 | 74.3 | 2.6: 1 |
Dermatofibrosarcoma, NOS | 93 | 2.7 | 0.3 | 0.2 | 50.2 | 95 | 2.8 | 0.3 | 0.2 | 45.8 | 1: 1 |
Liposarcoma
|
393
|
11.5
|
1.1
|
0.8
|
65.9
|
250
|
7.3
|
0.7
|
0.5
|
65.3
| 1.6: 1 |
Liposarcoma, NOS | 144 | 4.2 | 0.4 | 0.3 | 70.2 | 111 | 3.2 | 0.3 | 0.2 | 68.5 | 1.3: 1 |
Liposarcoma, well differentiated | 56 | 1.6 | 0.2 | 0.1 | 63.5 | 37 | 1.1 | 0.1 | 0.1 | 62.2 | 1.5: 1 |
Myxoid liposarcoma | 69 | 2.0 | 0.2 | 0.2 | 56.5 | 41 | 1.2 | 0.1 | 0.1 | 52.8 | 1.7: 1 |
Dedifferentiated liposarcoma | 89 | 2.6 | 0.3 | 0.2 | 70.8 | 32 | 0.9 | 0.1 | 0.1 | 69.6 | 2.8: 1 |
Uterine leiomyosarcoma
|
0
|
0.0
|
0.0
|
0.0
|
.
|
109
|
3.2
|
0.3
|
0.2
|
60.4
|
–
|
Non-uterine leiomyosarcoma
|
277
|
8.1
|
0.8
|
0.6
|
70.5
|
330
|
9.6
|
0.9
|
0.6
|
67.3
| 1: 1.2 |
Rhabdomyosarcoma
|
78
|
2.3
|
0.2
|
0.3
|
25.2
|
47
|
1.4
|
0.1
|
0.1
|
48.7
| 1.7: 1 |
Rhabdomyosarcoma, NOS | 19 | 0.6 | 0.1 | 0.1 | 53.3 | 18 | 0.5 | 0.1 | 0.0 | 56.3 | 1.1: 1 |
Embryonal rhabdomyosarcoma | 20 | 0.6 | 0.1 | 0.1 | 14.2 | 9 | 0.3 | 0.0 | 0.0 | 12.4 | 2.2: 1 |
Complex Neoplasia
|
169
|
5.0
|
0.5
|
0.4
|
61.2
|
741
|
21.5
|
2.1
|
1.3
|
69.8
| 1: 4.4 |
Endometrial stromal sarcoma, NOS | 0 | 0.0 | 0.0 | 0.0 | . | 75 | 2.2 | 0.2 | 0.1 | 62.2 | – |
Endometrial stromal sarcoma, low grade | 0 | 0.0 | 0.0 | 0.0 | . | 36 | 1.0 | 0.1 | 0.1 | 53.3 | – |
Adenosarcoma | 0 | 0.0 | 0.0 | 0.0 | . | 28 | 0.8 | 0.1 | 0.1 | 61.1 | – |
Mullerian mixed tumor | 0 | 0.0 | 0.0 | 0.0 | . | 206 | 6.0 | 0.6 | 0.3 | 72.6 | – |
Carcinosarcoma, NOS | 37 | 1.1 | 0.1 | 0.1 | 71.5 | 260 | 7.6 | 0.7 | 0.4 | 73.0 | 1: 7 |
Synovial sarcoma, NOS | 32 | 0.9 | 0.1 | 0.1 | 56.2 | 28 | 0.8 | 0.1 | 0.1 | 49.5 | 1.1: 1 |
Synovial sarcoma, spindle cell | 20 | 0.6 | 0.1 | 0.1 | 40.4 | 13 | 0.4 | 0.0 | 0.0 | 52.0 | 1.5: 1 |
Phylloides tumour, malignant
|
0
|
0.0
|
0.0
|
0.0
|
.
|
56
|
1.6
|
0.2
|
0.1
|
56.2
|
–
|
Angiosarcoma
|
233
|
6.8
|
0.7
|
0.5
|
69.5
|
168
|
4.9
|
0.5
|
0.3
|
72.8
| 1.4: 1 |
Haemangiosarcoma, NOS | 118 | 3.5 | 0.3 | 0.2 | 72.5 | 122 | 3.5 | 0.3 | 0.2 | 74.7 | 1: 1 |
Kaposi sarcoma | 87 | 2.6 | 0.3 | 0.2 | 61.4 | 17 | 0.5 | 0.0 | 0.0 | 72.9 | 5.1: 1 |
Osteosarcoma
|
85
|
2.5
|
0.2
|
0.3
|
35.8
|
67
|
1.9
|
0.2
|
0.2
|
39.8
| 1.3: 1 |
Osteosarcoma, NOS | 69 | 2.0 | 0.2 | 0.2 | 42.0 | 49 | 1.4 | 0.1 | 0.1 | 45.3 | 1.4: 1 |
Chondrosarcoma
|
105
|
3.1
|
0.3
|
0.2
|
60.8
|
119
|
3.5
|
0.3
|
0.2
|
61.4
| 1: 1.1 |
Chondrosarcoma, NOS | 81 | 2.4 | 0.2 | 0.2 | 60.8 | 100 | 2.9 | 0.3 | 0.2 | 62.0 | 1: 1.2 |
Giant cell neoplasia
|
4
|
0.1
|
0.0
|
0.0
|
56.6
|
5
|
0.1
|
0.0
|
0.0
|
58.3
| 1: 1.3 |
Ewing family of tumours
|
107
|
3.1
|
0.3
|
0.4
|
24.7
|
70
|
2.0
|
0.2
|
0.2
|
25.1
| 1.5: 1 |
Ewing sarcoma | 93 | 2.7 | 0.3 | 0.3 | 23.7 | 56 | 1.6 | 0.2 | 0.2 | 23.7 | 1.7: 1 |
Malignant ameloblastoma
|
2
|
0.1
|
0.0
|
0.0
|
72.8
|
4
|
0.1
|
0.0
|
0.0
|
50.0
| 1: 2 |
Chordoma
|
34
|
1.0
|
0.1
|
0.1
|
63.6
|
30
|
0.9
|
0.1
|
0.1
|
58.0
| 1.1: 1 |
Chordoma, NOS | 30 | 0.9 | 0.1 | 0.1 | 64.5 | 27 | 0.8 | 0.1 | 0.1 | 58.0 | 1.1: 1 |
Nerve sheath tumours
|
63
|
1.9
|
0.2
|
0.2
|
57.7
|
52
|
1.5
|
0.1
|
0.1
|
55.6
| 1.2: 1 |
Malignant peripheral nerve sheath tumour | 56 | 1.6 | 0.2 | 0.1 | 57.6 | 43 | 1.2 | 0.1 | 0.1 | 56.0 | 1.3: 1 |
GIST
|
734
|
21.6
|
2.1
|
1.5
|
69.5
|
619
|
18.0
|
1.7
|
1.1
|
70.2
| 1.2: 1 |
Men | Women | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Cases | Incidence Ratea | Change of Incidence Rate | Cases | Incidence Ratea | Change of Incidence Rate | |||||
2004 | 2013 | 2004 | 2013 | APCb (%) [95% CI] | 2004 | 2013 | 2004 | 2013 | APCb(%) [95% CI] | |
All sarcoma | 1752 | 2373 | 6.17 | 7.32 | 1.8 (1.0;2.6)* | 2191 | 2463 | 6.44 | 6.66 | 0.4 (0.1;0.8)*,** |
Soft tissue sarcoma | 1256 | 1614 | 4.38 | 4.94 | 0.9 (−0.2;1.9) | 1763 | 1816 | 5.11 | 4.85 | −0.7 (−1.3;-0.1)*,** |
Bone sarcoma | 239 | 209 | 0.95 | 0.82 | −1.1 (−3.1;0.9) | 194 | 189 | 0.70 | 0.70 | −0.5 (−2.0;1.1) |
GIST | 257 | 550 | 0.84 | 1.55 | 8.1 (6.0;10.2)* | 234 | 458 | 0.63 | 1.12 | 7.6 (5.7;9.5)* |
Federal State | All sarcoma | |||
---|---|---|---|---|
Men | Women | |||
n | Incidence (95%-CI)a | n | Incidence (95%-CI)a | |
Bayern | 2929 | 7.5 (7.3–7.8) | 3253 | 7.3 (7.0–7.6) |
Berlin | 586 | 5.9 (5.4–6.4) | 617 | 5.4 (5.0–5.9) |
Brandenburg | 545 | 6.6 (6.0–7.2) | 643 | 6.7 (6.1–7.2) |
Bremen | 154 | 7.3 (6.1–8.5) | 169 | 6.2 (5.1–7.2) |
Hamburg | 413 | 7.8 (7.0–8.6) | 506 | 8.7 (7.9–9.5) |
Hessen | 1222 | 5.9 (5.6–6.3) | 1276 | 5.5 (5.2–5.9) |
Mecklenburg-Vorpommern | 349 | 6.2 (5.5–6.9) | 422 | 6.6 (5.9–7.3) |
Niedersachsen | 1943 | 7.6 (7.3–8.0) | 1903 | 6.5 (6.2–6.8) |
Nordrhein-Westfalen | 4238 | 7.8 (7.5–8.0) | 4467 | 7.2 (7.0–7.4) |
Rheinland-Pfalz | 916 | 6.9 (6.4–7.3) | 926 | 6.2 (5.8–6.7) |
Saarland | 253 | 7.4 (6.4–8.3) | 272 | 6.6 (5.7–7.5) |
Sachsen | 1080 | 7.6 (7.1–8.0) | 1162 | 6.9 (6.4–7.3) |
Sachsen-Anhalt | 451 | 5.5 (5.0–6.1) | 491 | 5.2 (4.7–5.8) |
Schleswig-Holstein | 612 | 6.6 (6.0–7.1) | 725 | 7.0 (6.5–7.6) |
Thueringen | 474 | 6.3 (5.7–6.9) | 544 | 6.2 (5.6–6.8) |