Positron emission tomography (PET) myocardial perfusion imaging (MPI) using oxygen-15-labeled water (
15O-water) has been increasingly used in the evaluation of coronary artery disease (CAD).
15O-water has favorable kinetics for absolute quantification myocardial blood flow (MBF) that can be presented as parametric maps of stress MBF or myocardial flow reserve (MFR) enabling evaluation of regional perfusion abnormalities.
1 Prospective clinical studies have shown that both stress MBF and MFR assessed by
15O-water PET have high diagnostic accuracy in the detection of significant CAD defined as an abnormal fractional flow reserve (FFR) in patients with suspected CAD.
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4 In addition to diagnostic performance, clinical value of a diagnostic test depends on its ability to stratify patients at low or high risk of adverse events and impact on choosing subsequent treatment strategy. …